C5

Summary

Gene Symbol: C5
Description: complement C5
Alias: C5D, C5a, C5b, CPAMD4, ECLZB, complement C5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, C5a anaphylatoxin, anaphylatoxin C5a analog, complement component 5, prepro-C5
Species: human
Products:     C5

Top Publications

  1. Kurreeman F, Padyukov L, Marques R, Schrodi S, Seddighzadeh M, Stoeken Rijsbergen G, et al. A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis. PLoS Med. 2007;4:e278 pubmed
    ..Based on functional data in mice, we hypothesized that the immune-related genes complement component 5 (C5) and/or TNF receptor-associated factor 1 (TRAF1), located on Chromosome 9q33-34, would represent ..
  2. Behrens E, Finkel T, Bradfield J, Kim C, Linton L, Casalunovo T, et al. Association of the TRAF1-C5 locus on chromosome 9 with juvenile idiopathic arthritis. Arthritis Rheum. 2008;58:2206-7 pubmed publisher
  3. Moskovich O, Herzog L, Ehrlich M, Fishelson Z. Caveolin-1 and dynamin-2 are essential for removal of the complement C5b-9 complex via endocytosis. J Biol Chem. 2012;287:19904-15 pubmed publisher
    ..element of both innate and adaptive immunity, is executing complement-dependent cytotoxicity (CDC) with its C5b-9 protein complex that is assembled on cell surfaces and transmits to the cell death signals...
  4. Chai L, Song Y, Zee K, Leung W. Single nucleotide polymorphisms of complement component 5 and periodontitis. J Periodontal Res. 2010;45:301-8 pubmed publisher
    ..This study investigated whether tagging single nucleotide polymorphisms (SNPs) of the gene encoding complement component 5 (C5) are associated with periodontitis in a Hong Kong Chinese population...
  5. Panoulas V, Smith J, Nightingale P, Kitas G. Association of the TRAF1/C5 locus with increased mortality, particularly from malignancy or sepsis, in patients with rheumatoid arthritis. Arthritis Rheum. 2009;60:39-46 pubmed publisher
    Recent genome-wide association studies have identified TRAF1/C5 as a rheumatoid arthritis (RA) susceptibility locus...
  6. Hoke M, Speidl W, Schillinger M, Minar E, Zehetmayer S, Schönherr M, et al. Polymorphism of the complement 5 gene and cardiovascular outcome in patients with atherosclerosis. Eur J Clin Invest. 2012;42:921-6 pubmed publisher
    ..Performance of ELISA indicated a significant association of the C5 rs17611 variant with C5a plasma levels...
  7. Nishimoto K, Kochi Y, Ikari K, Yamamoto K, Suzuki A, Shimane K, et al. Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese. Ann Rheum Dis. 2010;69:368-73 pubmed publisher
    The primary aim of this study was to investigate the association of polymorphisms of TRAF1-C5, a newly identified rheumatoid arthritis (RA) risk locus in Caucasians, with susceptibility to RA and systemic lupus erythematosus (SLE) in ..
  8. Patsopoulos N, Ioannidis J. Susceptibility variants for rheumatoid arthritis in the TRAF1-C5 and 6q23 loci: a meta-analysis. Ann Rheum Dis. 2010;69:561-6 pubmed publisher
    Genome-wide association studies have proposed susceptibility variants for rheumatoid arthritis in the TRAF1-C5 locus and 6q23 region...
  9. Plant D, Thomson W, Lunt M, Flynn E, Martin P, Eyre S, et al. The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register. Rheumatology (Oxford). 2011;50:78-84 pubmed publisher
    ..SNP markers within the TRAF1/C5 locus were associated with erosive disease at Year 1 [rs2900180: odds ratio (OR) 1.53 (95% CI 1.14, 2...

More Information

Publications97

  1. Plenge R, Seielstad M, Padyukov L, Lee A, Remmers E, Ding B, et al. TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. N Engl J Med. 2007;357:1199-209 pubmed
    ..chronic inflammation: TRAF1 (encoding tumor necrosis factor receptor-associated factor 1) and C5 (encoding complement component 5)...
  2. Lee H, Korman B, Le J, Kastner D, Remmers E, Gregersen P, et al. Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations. Arthritis Rheum. 2009;60:364-71 pubmed publisher
    ..The aim of this study was to determine whether the genetic variants at 4q27, 6q23, CCL21, TRAF1/C5, and CD40 identified in Caucasians are also associated with RA in a Korean case-control collection...
  3. Woehrl B, Brouwer M, Murr C, Heckenberg S, Baas F, Pfister H, et al. Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis. J Clin Invest. 2011;121:3943-53 pubmed publisher
    ..genetic association study in patients with bacterial meningitis and found that a common nonsynonymous complement component 5 (C5) SNP (rs17611) is associated with unfavorable disease outcome...
  4. Hadders M, Bubeck D, Roversi P, Hakobyan S, Forneris F, Morgan B, et al. Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9. Cell Rep. 2012;1:200-7 pubmed publisher
    ..Cleavage of C5 to C5b results in marked conformational changes, distinct from those observed in the homologous C3-to-C3b transition...
  5. Mejri K, Mbarek H, Kallel Sellami M, Petit Teixeira E, Zerzeri Y, Abida O, et al. TRAF1/C5 polymorphism is not associated with pemphigus. Br J Dermatol. 2009;160:1348-50 pubmed publisher
  6. Zuiderweg E, Mollison K, Henkin J, Carter G. Sequence-specific assignments in the 1H NMR spectrum of the human inflammatory protein C5a. Biochemistry. 1988;27:3568-80 pubmed
    Full sequence-specific assignments for the 1H NMR lines of the backbone protons of the human complement factor C5a are described and documented. The results were obtained by largely following the methodology developed by Wüthrich et al...
  7. Liu Q, He S, Groysman L, Shaked D, Russin J, Scotton T, et al. White matter injury due to experimental chronic cerebral hypoperfusion is associated with C5 deposition. PLoS ONE. 2013;8:e84802 pubmed publisher
    The C5 complement protein is a potent inflammatory mediator that has been implicated in the pathogenesis of both stroke and neurodegenerative disease. Microvascular failure is proposed as a potential mechanism of injury...
  8. Gerard N, Gerard C. The chemotactic receptor for human C5a anaphylatoxin. Nature. 1991;349:614-7 pubmed
    ..receptors CR1 and CR3 are responsible for the phagocytic and adhesive properties of neutrophils, whereas the C5a receptor mediates the pro-inflammatory and chemotactic actions of the complement anaphylatoxin C5a...
  9. Colobran R, Franco Jarava C, Martín Nalda A, Baena N, Gabau E, Padilla N, et al. Novel Mutations Causing C5 Deficiency in Three North-African Families. J Clin Immunol. 2016;36:388-96 pubmed publisher
    ..The three activation pathways (classical, lectin, and alternative) converge in the cleavage of C5, which initiates MAC formation and target lysis...
  10. DiScipio R. Formation and structure of the C5b-7 complex of the lytic pathway of complement. J Biol Chem. 1992;267:17087-94 pubmed
    The formation and structure of the complement cytolytic intermediary complex, C5b-7, were studied with the aim of determining the interactive regions of C5, C6, and C7...
  11. Campbell W, Lazoura E, Okada N, Okada H. Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N. Microbiol Immunol. 2002;46:131-4 pubmed
    ..activation by thrombin/thrombomodulin and/or plasmin can remove arginine from the carboxyterminal of C3a and C5a. We have shown that this enzyme can remove terminal arginine from the C5a octapeptide much more efficiently than ..
  12. Thai C, Ogata R. Recombinant C345C and factor I modules of complement components C5 and C7 inhibit C7 incorporation into the complement membrane attack complex. J Immunol. 2005;174:6227-32 pubmed
    ..Using this method, we found that C7 binds to surface-bound C5b,6 with a K(d) of approximately 3 pM, and that micromolar concentrations of either rC5-C345C or rC7-FIMs inhibit ..
  13. Sprong T, Brandtzaeg P, Fung M, Pharo A, Høiby E, Michaelsen T, et al. Inhibition of C5a-induced inflammation with preserved C5b-9-mediated bactericidal activity in a human whole blood model of meningococcal sepsis. Blood. 2003;102:3702-10 pubmed
    ..moiety of C5 before cleavage prohibited CR3 up-regulation, phagocytosis, and oxidative burst but had no effect on C5b-9 (TCC) formation, lysis, and bacterial killing...
  14. van Steenbergen H, Rodríguez Rodríguez L, Berglin E, Zhernakova A, Knevel R, Ivorra Cortés J, et al. A genetic study on C5-TRAF1 and progression of joint damage in rheumatoid arthritis. Arthritis Res Ther. 2015;17:1 pubmed publisher
    ..Variants in Interleukin-6 (IL-6), Interleukin-10 (IL-10), C5-TRAF1, and Fc-receptor-like-3 (FCRL3) have been described to associate with radiographic progression, but results of ..
  15. Xu D, Hou S, Jiang Y, Zhang J, Cao S, Zhang D, et al. Complement C5 Gene Confers Risk for Acute Anterior Uveitis. Invest Ophthalmol Vis Sci. 2015;56:4954-60 pubmed publisher
    Polymorphisms in the genes encoding C3 and C5 are associated with several immune-mediated diseases...
  16. Ames R, Nuthulaganti P, Kumar C. In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins. FEBS Lett. 1996;395:157-9 pubmed
    ..Conversely, oocytes co-injected with the C5a receptor and total RNA isolated from U937 cells responded to C5a as well as to C3a and the C3a synthetic peptide...
  17. Zhu Y, Dai B, Li Y, Peng H. C5a and toll-like receptor 4 crosstalk in retinal pigment epithelial cells. Mol Vis. 2015;21:1122-9 pubmed
    To investigate the effect of the complement activation product C5a on toll-like receptor (TLR) 4-induced responses in RPE cells...
  18. Tack B, Morris S, Prahl J. Fifth component of human complement: purification from plasma and polypeptide chain structure. Biochemistry. 1979;18:1490-7 pubmed
  19. Laursen N, Magnani F, Gottfredsen R, Petersen S, Andersen G. Structure, function and control of complement C5 and its proteolytic fragments. Curr Mol Med. 2012;12:1083-97 pubmed
    ..elicits proteolytic cascades which eventually results in the cleavage of the C5 protein into two fragments, C5a and C5b...
  20. Hasegawa K, Tamari M, Shao C, Shimizu M, Takahashi N, Mao X, et al. Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. Hum Genet. 2004;115:295-301 pubmed
    ..to BA, we screened single nucleotide polymorphisms (SNPs) in C3, C5, the C3a receptor gene (C3AR1), and the C5a receptor gene (C5R1) and performed association studies in the Japanese population...
  21. Klco J, Wiegand C, Narzinski K, Baranski T. Essential role for the second extracellular loop in C5a receptor activation. Nat Struct Mol Biol. 2005;12:320-6 pubmed
    ..These results demonstrate an unexpected role for EC2 as a negative regulator of C5a receptor activation...
  22. Castellheim A, Pharo A, Fung M, Saugstad O, Mollnes T. Complement C5a is a key mediator of meconium-induced neutrophil activation. Pediatr Res. 2005;57:242-7 pubmed
    ..Complement was inhibited using the MAb 166-32 and 137-26, which block factor D and neutralize C5a, respectively...
  23. Huber Lang M, Denk S, Fulda S, Erler E, Kalbitz M, Weckbach S, et al. Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro. Mol Immunol. 2012;50:60-5 pubmed publisher
    ..both the early activation of the complement cascade with an excessive generation of the potent anaphylatoxin C5a and the induction of apoptosis have been shown to modulate the post-traumatic immune response...
  24. Franco Jarava C, Comas D, Orren A, Hernandez Gonzalez M, Colobran R. Complement factor 5 (C5) p.A252T mutation is prevalent in, but not restricted to, sub-Saharan Africa: implications for the susceptibility to meningococcal disease. Clin Exp Immunol. 2017;189:226-231 pubmed publisher
    b>Complement C5 deficiency (C5D) is a rare primary immunodeficiency associated with recurrent infections, particularly meningitis, by Neisseria species...
  25. Muller Eberhard H. Molecular organization and function of the complement system. Annu Rev Biochem. 1988;57:321-47 pubmed
  26. Ambati J, Anand A, Fernandez S, Sakurai E, Lynn B, Kuziel W, et al. An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Nat Med. 2003;9:1390-7 pubmed
    ..RPE or choroidal endothelial production of Ccl-2 induced by complement C5a and IgG may mediate choroidal macrophage infiltration into aged wild-type choroids...
  27. Metz M, Krull C, Maurer M. Histamine, TNF, C5a, IL-6, -9, -18, -31, -33, TSLP, neopterin, and VEGF are not elevated in chronic spontaneous urticaria. J Dermatol Sci. 2013;70:222-5 pubmed publisher
  28. Viedt C, Shen W, Fei J, Kamimura M, Hänsch G, Katus H, et al. HMG-CoA reductase inhibition reduces the proinflammatory activation of human vascular smooth muscle cells by the terminal complement factor C5b-9. Basic Res Cardiol. 2003;98:353-61 pubmed
    The terminal complement complex C5b-9 is known to participate in inflammatory processes including atherosclerosis. Inflammation appears to be a direct consequence of C5b-9-mediated cell stimulation...
  29. Jokiranta T, Westin J, Nilsson U, Nilsson B, Hellwage J, Lofas S, et al. Complement C3b interactions studied with surface plasmon resonance technique. Int Immunopharmacol. 2001;1:495-506 pubmed
    ..amine C3b coupling, we analyzed and compared the binding of four C3b ligands to the surface: factor B, factor H, C5 and the soluble complement receptor 1 (sCR1, CD35)...
  30. Hillebrandt S, Wasmuth H, Weiskirchen R, Hellerbrand C, Keppeler H, Werth A, et al. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nat Genet. 2005;37:835-43 pubmed
    ..Small molecule inhibitors of the C5a receptor had antifibrotic effects in vivo, and common haplotype-tagging polymorphisms of the human gene C5 were ..
  31. Banadakoppa M, Chauhan M, Havemann D, Balakrishnan M, Dominic J, Yallampalli C. Spontaneous abortion is associated with elevated systemic C5a and reduced mRNA of complement inhibitory proteins in placenta. Clin Exp Immunol. 2014;177:743-9 pubmed publisher
    ..Systemic levels of complement factors C3a and C5a were measured by enzyme-linked immunosorbent assay (ELISA)...
  32. Hussein M, Hashimoto T, Suzuki T, Daoud G, Goto T, Nakajima Y, et al. Children undergoing liver transplantation for treatment of inherited metabolic diseases are prone to higher oxidative stress, complement activity and transforming growth factor-?1. Ann Transplant. 2013;18:63-8 pubmed publisher
    ..Patients who receive living-related liver transplantation due to inherited metabolic diseases are prone to higher oxidative stress, complement activity, and serum transforming growth factor-ß1. ..
  33. Hua R, Xu J, Wang J, Zhu L, Li B, Liu Y, et al. Association of TNFAIP3 polymorphism with rheumatic heart disease in Chinese Han population. Immunogenetics. 2009;61:739-44 pubmed publisher
    ..protein 3 (TNFAIP3) gene, tumor necrosis factor receptor-associated factor 1 (TRAF1) gene, complement component 5 (C5) gene, and rheumatic heart disease (RHD)...
  34. Fosbrink M, Niculescu F, Rus V, Shin M, Rus H. C5b-9-induced endothelial cell proliferation and migration are dependent on Akt inactivation of forkhead transcription factor FOXO1. J Biol Chem. 2006;281:19009-18 pubmed
    ..Activation of complement and assembly of the C5b-9 complement complex have been implicated in the pre-lesional stage of atherogenesis and progression of the ..
  35. De Vries M, Wezel A, Schepers A, Van Santbrink P, Woodruff T, Niessen H, et al. Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease. Cardiovasc Res. 2013;97:311-20 pubmed publisher
    ..Interestingly, mast cells can be activated by complement factor C5a and, therefore, a direct role for C5a-mediated mast cell activation in vein graft disease is anticipated...
  36. Stangou M, Alexopoulos E, Pantzaki A, Leonstini M, Memmos D. C5b-9 glomerular deposition and tubular alpha3beta1-integrin expression are implicated in the development of chronic lesions and predict renal function outcome in immunoglobulin A nephropathy. Scand J Urol Nephrol. 2008;42:373-80 pubmed
    ..Monoclonal antibodies used were against C5b-9, alpha3beta1-integrin, transforming growth factor-beta1 (TGF-beta1) and alpha-smooth muscle actin (alpha-SMA), ..
  37. Luu N, Rainger G, Nash G. Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils. J Immunol. 2000;164:5961-9 pubmed
    ..If fMLP, IL-8, zymosan-activated plasma (a source of activated complement factor C5a), epithelial cell-derived neutrophil-activating peptide (ENA-78), or growth-regulating oncogene, GRO-alpha, was ..
  38. Hawksworth O, Coulthard L, Taylor S, Wolvetang E, Woodruff T. Brief report: complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2. Stem Cells. 2014;32:3278-84 pubmed publisher
    The complement activation product, C5a, is a pivotal member of the innate immune response; however, a diverse number of nonimmune functions are now being ascribed to C5a signaling, including roles during embryonic development...
  39. Kurreeman F, Rocha D, Houwing Duistermaat J, Vrijmoet S, Teixeira V, Migliorini P, et al. Replication of the tumor necrosis factor receptor-associated factor 1/complement component 5 region as a susceptibility locus for rheumatoid arthritis in a European family-based study. Arthritis Rheum. 2008;58:2670-4 pubmed publisher
    ..association study, that a 65-kb block encompassing tumor necrosis factor receptor-associated factor 1 (TRAF1) and C5 is strongly associated with rheumatoid arthritis (RA)...
  40. Shi H, Williams J, Guo L, Stampoulis D, Francesca Cordeiro M, Moss S. Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. Apoptosis. 2015;20:433-43 pubmed publisher
    ..Here we have used the 661W cone photoreceptor cell line to ask whether exposure to the terminal complement complex C5b-9 induces cell death and/or modulates the sensitivity of these cells to other cellular stressors...
  41. Gionanlis L, Alexopoulos E, Papagianni A, Leontsini M, Memmos D. Fibrotic mechanisms in idiopathic rapidly progressive glomerulonephritis: the role of TGF-beta1 and C5b-9. Ren Fail. 2008;30:239-46 pubmed publisher
    ..the expression of the adhesion molecule ICAM-1, the growth factor TGF-beta1, and the terminal complement component C5b-9. The presence of glomerular necrosis correlated positively with the number of SMA (+) cells in TIN (p = 0.036)...
  42. Babkina I, Seregin S, Daniliuk N, Siniakov A, Gladkova S, Pozdniakov S. [Chemico-enzymatic synthesis, cloning and expression of a gene for an analog of human anaphylatoxin C5a]. Bioorg Khim. 1995;21:359-64 pubmed
    Chemical-enzymatic synthesis and cloning of a gene for a human anaphylatoxin C5a analog were carried out. Recombinant plasmid pRC5a providing the expression of the synthetic gene in the Escherichia coli cells was obtained...
  43. Gancz D, Donin N, Fishelson Z. Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death. Mol Immunol. 2009;47:310-7 pubmed publisher
    Cell death and survival signals activated by the complement membrane attack complex C5b-9 play important roles in complement-associated diseases and in antibody-based cancer therapy...
  44. Foley J, Walton B, Aleman M, O Byrne A, Lei V, Harrasser M, et al. Complement Activation in Arterial and Venous Thrombosis is Mediated by Plasmin. EBioMedicine. 2016;5:175-82 pubmed publisher
    ..C5a generation greatly exceeded that of thrombin or factor Xa, but was similar to the recognized complement C5 convertases. Plasmin-activated C5 yielded a functional membrane attack complex (MAC)...
  45. Vuong M, Gunnarsson I, Lundberg S, Svenungsson E, Wramner L, Fernström A, et al. Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap. PLoS ONE. 2010;5:e10559 pubmed publisher
    ..In several autoimmune diseases, particularly in SLE, IRF5, STAT4 genes and TRAF1-C5 locus have been shown to be important candidate genes...
  46. Morgan A, Robinson J, Conaghan P, Martin S, Hensor E, Morgan M, et al. Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort. Arthritis Res Ther. 2010;12:R57 pubmed publisher
    ..five confirmed rheumatoid arthritis (RA) susceptibility genes/loci (HLA-DRB1, PTPN22, STAT4, OLIG3/TNFAIP3 and TRAF1/C5) for association with susceptibility and severity in an inception cohort...
  47. Heyer E, Kellner C, Malone H, Bruce S, Mergeche J, Ward J, et al. Complement polymorphisms and cognitive dysfunction after carotid endarterectomy. J Neurosurg. 2013;119:648-54 pubmed publisher
    ..In 252 patients undergoing CEA, genotyping was performed for the following polymorphisms: complement component 5 (C5) rs17611, mannose-binding lectin 2 (MBL2) rs7096206, and complement factor H (CFH) rs1061170...
  48. Hünniger K, Bieber K, Martin R, Lehnert T, Figge M, Löffler J, et al. A second stimulus required for enhanced antifungal activity of human neutrophils in blood is provided by anaphylatoxin C5a. J Immunol. 2015;194:1199-210 pubmed publisher
    ..In this model, PMN activation 10 min after C. albicans infection was largely dependent on the anaphylatoxin C5a. Most importantly, C5a enabled blood PMN to overcome filament-restricted recognition of C...
  49. Susal C, Kirschfink M, Kröpelin M, Daniel V, Opelz G. Identification of complement activation sites in human immunodeficiency virus type-1 glycoprotein gp120. Blood. 1996;87:2329-36 pubmed
    ..In the current study, the complement proteins C4,C3,C5,C9, and properdin were found to bind to a synthetic peptide covering positions 233-251 of the gp120BRU sequence on ..
  50. Croker D, Halai R, Fairlie D, Cooper M. C5a, but not C5a-des Arg, induces upregulation of heteromer formation between complement C5a receptors C5aR and C5L2. Immunol Cell Biol. 2013;91:625-33 pubmed publisher
    Receptors for C5a have an important role in innate immunity and inflammation where their expression and activation is tightly regulated...
  51. Prahalad S, Hansen S, Whiting A, Guthery S, Clifford B, McNally B, et al. Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis. Arthritis Rheum. 2009;60:2124-30 pubmed publisher
    ..in the TNFAIP3 locus, rs6679677 in the RSBN1 locus, rs17696736 in the C12orf30 locus, rs3761847 in the TRAF1/C5 locus, rs2104286 in the IL2RA locus, rs7574865 in the STAT4 locus, and rs2542151 in the PTPN2 locus...
  52. Haviland D, Haviland J, Fleischer D, Hunt A, Wetsel R. Complete cDNA sequence of human complement pro-C5. Evidence of truncated transcripts derived from a single copy gene. J Immunol. 1991;146:362-8 pubmed
    Two truncated human C5 clones, pHC5A and pHC5B, were isolated from an adult human liver cDNA library, and contained inserts of 2930 and 2181 bp, respectively...
  53. Nitta H, Murakami Y, Wada Y, Eto M, Baba H, Imamura T. Cancer cells release anaphylatoxin C5a from C5 by serine protease to enhance invasiveness. Oncol Rep. 2014;32:1715-9 pubmed publisher
    Anaphylatoxin C5a indirectly fosters cancer cells through recruitment of myeloid-derived suppressor cells (MDS) for inhibiting antitumor CD8+ T cells and induction of neovascularization...
  54. Du Y, Zhang Q, Han B. Genetic variants of C5 and polymorphisms of C3 in Chinese patients with paroxysmal nocturnal hemoglobinuria. Int J Lab Hematol. 2016;38:e84-5 pubmed publisher
  55. Xu D, Hou S, Zhang J, Jiang Y, Kijlstra A, Yang P. Copy number variations and gene polymorphisms of complement components in ocular Behcet's disease and Vogt-Koyanagi-Harada syndrome. Sci Rep. 2015;5:12989 pubmed publisher
    ..The frequencies of having more than two copies of C3 were significantly increased in BD and VKH, whereas CNV of C5 was only associated with BD...
  56. Bestebroer J, Aerts P, Rooijakkers S, Pandey M, K hl J, Van Strijp J, et al. Functional basis for complement evasion by staphylococcal superantigen-like 7. Cell Microbiol. 2010;12:1506-16 pubmed publisher
    ..SSL7 has been described to bind immunoglobulin A (IgA) and complement C5, thereby inhibiting IgA-Fc?RI binding and serum killing of Escherichia coli...
  57. Bramham J, Thai C, Soares D, Uhrin D, Ogata R, Barlow P. Functional insights from the structure of the multifunctional C345C domain of C5 of complement. J Biol Chem. 2005;280:10636-45 pubmed
    ..It interacts with enzymes that convert C5 to C5b, the first step in the assembly of the membrane attack complex; it also binds to the membrane attack complex ..
  58. Palomino Morales R, Gonzalez Juanatey C, Vazquez Rodriguez T, Rodriguez L, Miranda Filloy J, Pascual Salcedo D, et al. Lack of association of PTPN22, STAT4 and TRAF1/C5 gene polymorphisms with cardiovascular risk in rheumatoid arthritis. Clin Exp Rheumatol. 2010;28:695-701 pubmed
    To determine whether the PTPN22, STAT4 and TRAF1/C5 gene polymorphisms may be implicated in the development of cardiovascular (CV) events and subclinical atherosclerosis manifested by the presence of endothelial dysfunction or increased ..
  59. Kastl S, Speidl W, Kaun C, Rega G, Assadian A, Weiss T, et al. The complement component C5a induces the expression of plasminogen activator inhibitor-1 in human macrophages via NF-kappaB activation. J Thromb Haemost. 2006;4:1790-7 pubmed
    ..Complement components were identified in atherosclerotic plaques, and a correlation between adverse events and C5a plasma levels was found...
  60. Wetsel R, Lemons R, Le Beau M, Barnum S, Noack D, Tack B. Molecular analysis of human complement component C5: localization of the structural gene to chromosome 9. Biochemistry. 1988;27:1474-82 pubmed
    A human C5 clone (pC5HG2) was isolated from a cDNA library constructed from Hep G2 mRNA...
  61. Weerth S, Rus H, Shin M, Raine C. Complement C5 in experimental autoimmune encephalomyelitis (EAE) facilitates remyelination and prevents gliosis. Am J Pathol. 2003;163:1069-80 pubmed
    ..We have analyzed the role of complement component C5 in experimental autoimmune encephalomyelitis (EAE) using C5-deficient (C5-d) and C5-sufficient (C5-s) mice...
  62. Owen E, Würzner R, Leisegang F, Rizkallah P, Whitelaw A, Simpson J, et al. A complement C5 gene mutation, c.754G>A:p.A252T, is common in the Western Cape, South Africa and found to be homozygous in seven percent of Black African meningococcal disease cases. Mol Immunol. 2015;64:170-6 pubmed publisher
    Patients with genetically determined deficiency of complement component 5 are usually diagnosed because of recurrent invasive Neisseria meningitidis infections. Approximately 40 individual cases have been diagnosed worldwide...
  63. Brandstetter C, Holz F, Krohne T. Complement Component C5a Primes Retinal Pigment Epithelial Cells for Inflammasome Activation by Lipofuscin-mediated Photooxidative Damage. J Biol Chem. 2015;290:31189-98 pubmed publisher
    ..of primary human RPE cells and ARPE-19 cells with complement-competent human serum resulted in up-regulation of C5a receptor, but not C3a receptor...
  64. Roach T, Rebres R, Fraser I, Decamp D, Lin K, Sternweis P, et al. Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium. J Biol Chem. 2008;283:17351-61 pubmed publisher
    ..We found a synergistic response to complement component 5a (C5a) in combination with uridine 5'-diphosphate (UDP), platelet activating factor (PAF), or lysophosphatidic acid (LPA)...
  65. Jeong J, Hwang Y, Kim H, Ro H, Park H, Kim Y, et al. Association of complement 5 genetic polymorphism with renal allograft outcomes in Korea. Nephrol Dial Transplant. 2011;26:3378-85 pubmed publisher
    ..Complement 5 (C5) is a pivotal complement, which initiates the assembly of the membrane attack complex, and mediates chemotaxis of ..
  66. Thai C, Ogata R. Expression and characterization of the C345C/NTR domains of complement components C3 and C5. J Immunol. 2003;171:6565-73 pubmed
    Complement components C3, C4, and C5 are members of the thioester-containing alpha-macroglobulin protein superfamily...
  67. Sakashita M, Yamada T, Imoto Y, Hirota T, Tamari M, Ito Y, et al. Long-term sublingual immunotherapy for Japanese cedar pollinosis and the levels of IL-17A and complement components 3a and 5a. Cytokine. 2015;75:181-5 pubmed publisher
    ..screened molecules as candidate biomarkers, and investigated serum IL-17A and complement components 3a (C3a) and C5a in order to evaluate whether these molecules show changes correlated to symptom scores...
  68. Moskovich O, Fishelson Z. Live cell imaging of outward and inward vesiculation induced by the complement c5b-9 complex. J Biol Chem. 2007;282:29977-86 pubmed
    Cells resist death induced by the complement membrane attack complex (MAC, C5b-9) by removal of the MAC from their surface by an outward and/or inward vesiculation...
  69. Burk A, Martin M, Flierl M, Rittirsch D, Helm M, Lampl L, et al. Early complementopathy after multiple injuries in humans. Shock. 2012;37:348-54 pubmed publisher
    ..Serum levels of the complement activation products C3a and C5a were significantly elevated throughout the entire observation period and correlated with the severity of traumatic ..
  70. Nording H, Giesser A, Patzelt J, Sauter R, Emschermann F, Stellos K, et al. Platelet bound oxLDL shows an inverse correlation with plasma anaphylatoxin C5a in patients with coronary artery disease. Platelets. 2016;27:593-597 pubmed
    ..In the present study, we investigated the relationship of markers of complement activation, the anaphylatoxins C5a and C3a, and oxidized low-density lipoprotein...
  71. Lee Y, Song G. Associations between TNFSF4 and TRAF1-C5 gene polymorphisms and systemic lupus erythematosus: a meta-analysis. Hum Immunol. 2012;73:1050-4 pubmed publisher
    ..whether tumor necrosis factor superfamily 4 (TNFSF4) and TNF receptor-associated factor 1-complement 5 (TRAF1-C5) polymorphisms confer susceptibility to systemic lupus erythematosus (SLE)...
  72. Nitta H, Imamura T, Wada Y, Irie A, Kobayashi H, Okamoto K, et al. Production of C5a by ASP, a serine protease released from Aeromonas sobria. J Immunol. 2008;181:3602-8 pubmed
    ..However, the mechanisms underlying these effects have not been elucidated. C5a, the amino-terminal fragment of the complement 5th component (C5), mimics these events...
  73. Haefliger J, Tschopp J, Vial N, Jenne D. Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6. J Biol Chem. 1989;264:18041-51 pubmed
    ..is one of five plasma proteins that are incorporated into the lytic terminal complement complex on lipid membranes (C5b-9m) upon activation of the complement cascade...
  74. Denk S, Taylor R, Wiegner R, Cook E, Lindorfer M, Pfeiffer K, et al. Complement C5a-Induced Changes in Neutrophil Morphology During Inflammation. Scand J Immunol. 2017;86:143-155 pubmed publisher
    ..For neutrophil migration to the inflamed region, we hypothesized that the complement activation product C5a induces significant changes in cellular morphology before chemotaxis...
  75. Susal C, Kirschfink M, Kröpelin M, Daniel V, Opelz G. Complement activation by recombinant HIV-1 glycoprotein gp120. J Immunol. 1994;152:6028-34 pubmed
    ..We found that the complement proteins C4, C3d, C5b-9, and properdin bind to rgp 120-coated CD4+ T cells of healthy individuals when incubated in autologous serum...
  76. Sundqvist J, Falconer H, Seddighzadeh M, Vodolazkaia A, Fassbender A, Kyama C, et al. Endometriosis and autoimmune disease: association of susceptibility to moderate/severe endometriosis with CCL21 and HLA-DRB1. Fertil Steril. 2011;95:437-40 pubmed publisher
    ..This study investigates the association of rheumatoid arthritis-associated single nucleotide polymorphisms in endometriosis. We found an association of CCL21 (rs2812378) and HLA-DRB1 (rs660895) with moderate to severe endometriosis. ..
  77. McClure A, Lunt M, Eyre S, Ke X, Thomson W, Hinks A, et al. Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci. Rheumatology (Oxford). 2009;48:1369-74 pubmed publisher
    ..shared epitope (SE) of HLA--DRB1, the PTPN22 gene, a locus on 6q23, the STAT4 gene and a locus mapping to the TRAF1/C5 genetic region--have now been unequivocally confirmed as conferring susceptibility to RA...
  78. Schlosser R, Mulligan R, Casey S, Varela J, Harvey R, Atkinson C. Alterations in gene expression of complement components in chronic rhinosinusitis. Am J Rhinol Allergy. 2010;24:21-5 pubmed publisher
    ..AFRS), CRS without NPs (CRS-NPs), and controls were harvested and gene and protein expression of C3, factor B (fB), C5, and C7 complement proteins were analyzed using quantitative polymerase chain reaction and immunohistochemical ..
  79. Helske S, Oksjoki R, Lindstedt K, Lommi J, Turto H, Werkkala K, et al. Complement system is activated in stenotic aortic valves. Atherosclerosis. 2008;196:190-200 pubmed
    ..The terminal complement complex C5b-9 was stained by immunohistochemistry...
  80. Thai C, Ogata R. Complement components C5 and C7: recombinant factor I modules of C7 bind to the C345C domain of C5. J Immunol. 2004;173:4547-52 pubmed
    ..These reversible reactions are distinct from the essentially nonreversible associations with activated C5b that occur during assembly of the membrane attack complex, but they likely involve some, perhaps many, of the same ..
  81. Yates J, Sepp T, Matharu B, Khan J, Thurlby D, Shahid H, et al. Complement C3 variant and the risk of age-related macular degeneration. N Engl J Med. 2007;357:553-61 pubmed
    ..age-related macular degeneration and 13 single-nucleotide polymorphisms (SNPs) spanning the complement genes C3 and C5 in case subjects and control subjects from the southeastern region of England...
  82. Arnaout R, Al Shorbaghi S, Al Dhekri H, Al Mousa H, Al Ghonaium A, Al Saud B, et al. C5 complement deficiency in a Saudi family, molecular characterization of mutation and literature review. J Clin Immunol. 2013;33:871-5 pubmed publisher
    ..from the Arabian Gulf region with multiple members affected by meningococcemia and abscent serum complement 5 (C5). We tried to correlate clinical, biochemical and molecular genetics features of this family...
  83. Dubruc E, Nadaud B, Ruchelli E, Heissat S, Baruteau J, Broué P, et al. Relevance of C5b9 immunostaining in the diagnosis of neonatal hemochromatosis. Pediatr Res. 2017;81:712-721 pubmed publisher
    ..Diagnosis and therapeutic management of GALD cannot only be based on C5b9 expression in liver samples as it is not specific of this disease. ..
  84. Nozaki M, Raisler B, Sakurai E, Sarma J, Barnum S, Lambris J, et al. Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci U S A. 2006;103:2328-33 pubmed
    ..Here we provide evidence that bioactive fragments of these complement components (C3a and C5a) are present in drusen of patients with AMD, and that C3a and C5a induce VEGF expression in vitro and in vivo...
  85. Delgado Cerviño E, Fontan G, Lopez Trascasa M. C5 complement deficiency in a Spanish family. Molecular characterization of the double mutation responsible for the defect. Mol Immunol. 2005;42:105-11 pubmed
    The complement C5 deficiency is a recessive autosomal defect associated with recurrent infectious episodes, generally caused by Gram-negative micro-organisms...
  86. Idonije O, Akinlade K, Ihenyen O, Arinola O. Complement factors in newly diagnosed Nigerian schizoprenic patients and those on antipsychotic therapy. Niger J Physiol Sci. 2012;27:19-21 pubmed
    ..this issue, levels of Complement regulators (C1 inhibitor and C3 activator) and complement factors (C1q, C3c, C4 and C5) were determined in the serum of newly diagnosed drug free schizophrenic patients, schizophrenic patients on ..
  87. Stahel P, Frei K, Eugster H, Fontana A, Hummel K, Wetsel R, et al. TNF-alpha-mediated expression of the receptor for anaphylatoxin C5a on neurons in experimental Listeria meningoencephalitis. J Immunol. 1997;159:861-9 pubmed
    The anaphylatoxin C5a has been implicated in the pathogenesis of bacterial meningitis as a potent mediator of inflammation in the subarachnoid space...
  88. Floreani A, Heires A, Welniak L, Miller Lindholm A, Clark Pierce L, Rennard S, et al. Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke. J Immunol. 1998;160:5073-81 pubmed
    ..a heightened responsiveness of human bronchial epithelial cells (HBECs) toward the complement-derived anaphylatoxin C5a when these cells are exposed to cigarette smoke...