C4BPA

Summary

Gene Symbol: C4BPA
Description: complement component 4 binding protein alpha
Alias: C4BP, PRP, C4b-binding protein alpha chain, proline-rich protein
Species: human
Products:     C4BPA

Top Publications

  1. Garcia de Frutos P, Härdig Y, Dahlback B. Serum amyloid P component binding to C4b-binding protein. J Biol Chem. 1995;270:26950-5 pubmed
    Human C4b-binding protein (C4BP), which is a regulator of the classical complement pathway C3 convertase, forms high affinity complexes with anticoagulant protein S and with the pentraxin serum amyloid P component (SAP)...
  2. Happonen K, Sjöberg A, Morgelin M, Heinegard D, Blom A. Complement inhibitor C4b-binding protein interacts directly with small glycoproteins of the extracellular matrix. J Immunol. 2009;182:1518-25 pubmed
    ..and proline arginine-rich end leucine-rich repeat protein bind to the complement inhibitor C4b-binding protein (C4BP)...
  3. Sjöberg A, Nyström S, Hammarstrom P, Blom A. Native, amyloid fibrils and beta-oligomers of the C-terminal domain of human prion protein display differential activation of complement and bind C1q, factor H and C4b-binding protein directly. Mol Immunol. 2008;45:3213-21 pubmed publisher
    Prion protein (PrP) is an endogenous protein involved in the pathogenesis of bovine spongiform encephalopathy and Creutzfeldt-Jakob disease...
  4. Xiang J, Li X, Chen Y, Lu Y, Yu M, Chen X, et al. Complement factor I from flatfish half-smooth tongue (Cynoglossus semilaevis) exhibited anti-microbial activities. Dev Comp Immunol. 2015;53:199-209 pubmed publisher
    ..In the presence of substrate modulating cofactors (such as complement factor H, C4bp, CR1, etc), Cfi cleaves and inactivates C3b and C4b, thereby controlling the complement-mediated processes...
  5. Noh K, Park S, Yang C, Lee G, Kim M, Kang Y. Involvement of synovial matrix degradation and angiogenesis in oxidative stress-exposed degenerative rotator cuff tears with osteoarthritis. J Shoulder Elbow Surg. 2018;27:141-150 pubmed publisher
    ..Cytokines, growth factors, and angiogenic biomarkers in synovial fluids, blood, platelet-rich plasma (PRP), and tendon tissues were analyzed with enzyme-linked immunosorbent assay, immunoblotting, and collagen zymography...
  6. Wang J, Lei X, Cheng X, Zhang X, Liu G, Cheng J, et al. LW-AFC, a new formula derived from Liuwei Dihuang decoction, ameliorates behavioral and pathological deterioration via modulating the neuroendocrine-immune system in PrP-hA?PPswe/PS1?E9 transgenic mice. Alzheimers Res Ther. 2016;8:57 pubmed
    ..Notably, we previously revealed that the NIM network is dysregulated in the PrP-hA?PPswe/PS1?E9 (APP/PS1) transgenic mouse model of AD...
  7. Chang C, Tung Y, Lin Y, Liao C, Chiu C, Tung T, et al. Effects of Caloric Restriction with Protein Supplementation on Plasma Protein Profiles in Middle-Aged Women with Metabolic Syndrome-A Preliminary Open Study. J Clin Med. 2019;8: pubmed publisher
    ..spectrometry analysis, the relative plasma levels of alpha-2-macroglobulin (A2M), C4b-binding protein alpha chain (C4BPA), complement C1r subcomponent-like protein (C1RL), complement component C6 (C6), complement component C8 gamma ..
  8. Kanwar J, Kanwar R, Sun X, Punj V, Matta H, Morley S, et al. Molecular and biotechnological advances in milk proteins in relation to human health. Curr Protein Pept Sci. 2009;10:308-38 pubmed
    ..3) A Proline rich polypeptide [PRP] revealed variety of immunotropic functions, including promotion of T-cell activation and inhibition of autoimmune ..
  9. Guner S, Guner S, Gokalp M, Ceylan M, Unsal S, Demir H. Do the trace elements play a role in the etiopathogenesis of developmental dysplasia of hip?. Eur Rev Med Pharmacol Sci. 2018;22:910-913 pubmed publisher
    ..This work should be supported by future studies concerning the causes of the alterations in the serum trace element levels seen in patients with developmental dysplasia of the hip. ..

More Information

Publications154 found, 100 shown here

  1. Osiecka Iwan A, Moskalewski S, Hyc A. Influence of IGF1, TGF?1, bFGF and G-CSF/M-CSF on the mRNA levels of selected matrix proteins, cytokines, metalloproteinase 3 and TIMP1 in rat synovial membrane cells. Folia Histochem Cytobiol. 2016;54:159-165 pubmed publisher
    ..of our study can improve understanding of synovial membrane responses to the intraarticular injections of platelet-rich plasma (PRP) used for the treatment of joint ailments, since PRP contains factors which are also present in CIF.
  2. Fang Y, Ning A, Li S, Zhou S, Liu L, Joseph T, et al. Polysaccharides Extracted from Rhizoma Pleionis Have Antitumor Properties In Vitro and in an H22 Mouse Hepatoma Ascites Model In Vivo. Int J Mol Sci. 2018;19: pubmed publisher
    ..In the current study, we investigated the effect of polysaccharides isolated from Rhizoma Pleionis (PRP) on murine hepatocarcinoma H22 cells in an ascites model...
  3. Roy N, Ohtani K, Hidaka Y, Amano Y, Matsuda Y, Mori K, et al. Three pentraxins C-reactive protein, serum amyloid p component and pentraxin 3 mediate complement activation using Collectin CL-P1. Biochim Biophys Acta Gen Subj. 2017;1861:1-14 pubmed publisher
    ..In addition, depletion of CFH, C4BP and complement factor I (CFI) failed to prevent TCC formation both in ELISA and cell experiments...
  4. Fei Y, Wang S, Yang L, Qiu Y, Li Y, Liu W, et al. Salvia miltiorrhiza Bunge (Danshen) extract attenuates permanent cerebral ischemia through inhibiting platelet activation in rats. J Ethnopharmacol. 2017;207:57-66 pubmed publisher
    ..In order to investigate the effects of SCED on platelet aggregation, rat platelet-rich-plasma (PRP) were incubated with SCED prior to the addition of the stimuli (ADP or 9, 11-dideoxy-11?, 9?-..
  5. Scano P, Rosa A, Incani A, Maestrale C, Santucciu C, Perra D, et al. (1)H NMR brain metabonomics of scrapie exposed sheep. Mol Biosyst. 2015;11:2008-16 pubmed publisher
    ..On the basis of clinical examinations and western blotting analysis for the pathological prion protein (PrP(Sc)) in brain tissues, sheep were catalogued as not infected (H), infected with clinical signs (S), and infected ..
  6. Shah S, Zhao D, Taglialatela G, Khan S, Hussain T, Dong H, et al. Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters. Neurotherapeutics. 2017;14:463-483 pubmed publisher
    ..Gliosis is likely to be caused initially by the deposition of misfolded, proteinase K-resistant, isoforms (termed PrPSc) of the normal cellular prion protein (PrPc) in the brain...
  7. Soliman A, Saif Elnasr M, Abdel Fattah S. Platelet-rich plasma ameliorates gamma radiation-induced nephrotoxicity via modulating oxidative stress and apoptosis. Life Sci. 2019;219:238-247 pubmed publisher
    As a source of growth factors and with its cytoprotective properties, platelet-rich plasma (PRP) received considerable attention in regenerative medicine...
  8. Sun Y, Zhang R, Mao X, Zhang M. [Research of acellular xenogeneic nerve combined with adipose-derived stem cells and platelet rich plasma in repair of rabbit facial nerve injury]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2018;32:736-744 pubmed publisher
    ..effects of acellular xenogeneic nerve combined with adipose-derived stem cells (ADSCs) and platelet rich plasma (PRP) in repairing facial nerve injury in rabbits...
  9. Veronesi F, Pagani S, Torricelli P, Filardo G, Cavallo C, Grigolo B, et al. PRP and MSCs on tenocytes artificial wound healing: an in vitro study comparing fresh and frozen PRP. Histol Histopathol. 2018;33:1323-1334 pubmed publisher
    ..MSCs show several advantages in tendon clinical setting, while platelet rich plasma (PRP) has gained popularity because of its high GF concentration, although its applications in the tendon clinical ..
  10. Richards M, Maxwell J, Weng L, Angelos M, Golzarian J. Intra-articular treatment of knee osteoarthritis: from anti-inflammatories to products of regenerative medicine. Phys Sportsmed. 2016;44:101-8 pubmed publisher
    ..acid, analgesics, local anesthetics, and newer products of regenerative medicine, such as platelet-rich plasma (PRP) and mesenchymal stem cells (MSC), were analyzed...
  11. Carroll J, Race B, Phillips K, Striebel J, Chesebro B. Statins are ineffective at reducing neuroinflammation or prolonging survival in scrapie-infected mice. J Gen Virol. 2017;98:2190-2199 pubmed publisher
    ..We evaluated scrapie-infected mice for protease-resistant PrP (PrPres) accumulation, gliosis, neuroinflammation and time until advanced clinical disease requiring euthanasia...
  12. Młodawska W, Grzesiak M, Kochan J, Nowak A. Intrafollicular level of steroid hormones and the expression of androgen receptor in the equine ovary at puberty. Theriogenology. 2018;121:13-20 pubmed publisher
    ..The ovaries of 6-18 month-old fillies were divided into two groups: prepubertal (PrP) - without preovulatory follicle (pF) and corpus luteum (CL), and ovulating/postpubertal (Ov/pB) - with pF and/or ..
  13. Zhang X, Shi K, Jia P, Jiang L, Liu Y, Chen X, et al. Effects of platelet-rich plasma on angiogenesis and osteogenesis-associated factors in rabbits with avascular necrosis of the femoral head. Eur Rev Med Pharmacol Sci. 2018;22:2143-2152 pubmed publisher
    Platelet-rich plasma (PRP) contains various growth factors and cytokines that can enhance the recovery of the damaged tissues...
  14. Çetinkaya R, Yenilmez E, Petrone P, Yılmaz S, Bektöre B, Şimsek B, et al. Platelet-rich plasma as an additional therapeutic option for infected wounds with multi-drug resistant bacteria: in vitro antibacterial activity study. Eur J Trauma Emerg Surg. 2018;: pubmed publisher
    ..Based on these facts, there is a need for supportive localized treatment options such as platelet-rich plasma (PRP) implementations...
  15. Liu D, Xu X, Zhuang M, Song M, Qin W, Wang X, et al. [Suppressive effect of exogenous carbon monoxide on abnormal platelet exocytosis and its molecular mechanism in sepsis]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2016;28:110-6 pubmed publisher
    ..Venous blood was collected from healthy volunteers. Platelet-rich plasma (PRP) was isolated from the blood by differential centrifugation...
  16. Salvesen Ø, Reiten M, Espenes A, Bakkebø M, Tranulis M, Ersdal C. LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface. J Neuroinflammation. 2017;14:106 pubmed publisher
    The cellular prion protein (PrPC) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system...
  17. Liu W, Liu X, Shen M, She G, Ye B. The Nitrogen Regulator GlnR Directly Controls Transcription of the prpDBC Operon Involved in Methylcitrate Cycle in Mycobacterium smegmatis. J Bacteriol. 2019;201: pubmed publisher
    ..Here, we found a typical GlnR binding box in the prp operon, and the affinity is much stronger than that of PrpR, a transcriptional activator of methylcitrate cycle...
  18. Haleem K, Ali Y, Yesilkaya H, Kohler T, Hammerschmidt S, Andrew P, et al. The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface. Infect Immun. 2019;87: pubmed publisher
    ..virulence factors on the pneumococcus are thought to facilitate this process by sequestering C4b-binding protein (C4BP) from host plasma. When S...
  19. Chellini F, Tani A, Vallone L, Nosi D, Pavan P, Bambi F, et al. Platelet-Rich Plasma Prevents In Vitro Transforming Growth Factor-?1-Induced Fibroblast to Myofibroblast Transition: Involvement of Vascular Endothelial Growth Factor (VEGF)-A/VEGF Receptor-1-Mediated Signaling †. Cells. 2018;7: pubmed publisher
    The antifibrotic potential of platelet-rich plasma (PRP) is controversial...
  20. Zhao Z, Liu X, Shi S, Li H, Gao F, Zhong X, et al. Exogenous hydrogen sulfide protects from endothelial cell damage, platelet activation, and neutrophils extracellular traps formation in hyperhomocysteinemia rats. Exp Cell Res. 2018;370:434-443 pubmed publisher
    ..the concentration of DNA in serum and supernatant of cultured neutrophils stimulated with platelet-rich plasma (PRP) were tested by Sytox Green and PicoGreen commercial Kits...
  21. Du J, Zhu H, Cao C, Ma Y. Expression of Macrobrachium rosenbergii lipopolysaccharide- and β-1,3-glucan-binding protein (LGBP) in Saccharomyces cerevisiae and evaluation of its immune function. Fish Shellfish Immunol. 2019;84:341-351 pubmed publisher
    ..immune system in invertebrates, and lipopolysaccharide- and β-1,3-glucan-binding protein (LGBP) is an important PRP with various biological functions...
  22. Nemani S, Notari S, Cali I, Alvarez V, Kofskey D, Cohen M, et al. Co-occurrence of chronic traumatic encephalopathy and prion disease. Acta Neuropathol Commun. 2018;6:140 pubmed publisher
    ..The histopathological phenotype and properties of the abnormal, disease-related prion protein (PrPD) of the three CTE cases were examined using lesion profile, immunohistochemistry, electrophoresis and ..
  23. Ortega V, Sastoque D. New and Successful Technique for the Management of Parry-Romberg Syndrome's Soft Tissue Atrophy. J Craniofac Surg. 2015;26:e507-10 pubmed publisher
    ..and glycosaminoglycan, and a semipermeable polysiloxane (silicone layer) and fat grafts enriched with Harvest PRP, to produce volume and symmetric contour on the affected side...
  24. Mannava S, Whitney K, Kennedy M, King J, Dornan G, Klett K, et al. The Influence of Naproxen on Biological Factors in Leukocyte-Rich Platelet-Rich Plasma: A Prospective Comparative Study. Arthroscopy. 2019;35:201-210 pubmed publisher
    ..and compare normative catabolic and anabolic factor concentrations in leukocyte-rich platelet-rich plasma (LR-PRP) at various time points, including baseline, 1 week after initiating naproxen use, and after a 1-week washout ..
  25. Xu X, Hu J, Lu H. Histological observation of a gelatin sponge transplant loaded with bone marrow-derived mesenchymal stem cells combined with platelet-rich plasma in repairing an annulus defect. PLoS ONE. 2017;12:e0171500 pubmed publisher
    ..of a gelatin sponge transplant loaded with goat BMSCs (bone marrow-derived mesenchymal stem cells) combined with PRP (platelet-rich plasma) in repairing an annulus defect...
  26. Pak J, Lee J, Pak N, Park K, Jeon J, Jeong B, et al. Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration. J Vis Exp. 2018;: pubmed publisher
    ..ECM excretes various cytokines that, along with hyaluronic acid (HA) and platelet-rich plasma (PRP) activated by calcium chloride, may help MSCs to regenerate cartilage and improve knee functions...
  27. Hayashi Y, Iwasaki Y, Yoshikura N, Asano T, Hatano T, Tatsumi S, et al. Decreased regional cerebral blood flow in the bilateral thalami and medulla oblongata determined by an easy Z-score (eZIS) analysis of (99m)Tc-ECD-SPECT images in a case of MM2-thalamic-type sporadic Creutzfeldt-Jakob disease. J Neurol Sci. 2015;358:447-52 pubmed publisher
    ..A slight depletion of Purkinje cells was observed. PrP immunostaining showed no obvious PrP deposits in the basal ganglia, thalamus, cerebellum, or brainstem; however, ..
  28. Ermert D, Weckel A, Magda M, Morgelin M, Shaughnessy J, Rice P, et al. Human IgG Increases Virulence of Streptococcus pyogenes through Complement Evasion. J Immunol. 2018;200:3495-3505 pubmed publisher
    ..strategies include recruiting several human plasma proteins, such as the complement inhibitor, C4b-binding protein (C4BP), and human (hu)-IgG through its Fc region to the bacterial surface to evade immune recognition...
  29. Mörschbächer P, Alves Garcez T, Paz A, Magrisso A, Mello H, Rolim V, et al. Treatment of dilated cardiomyopathy in rabbits with mesenchymal stem cell transplantation and platelet-rich plasma. Vet J. 2016;209:180-5 pubmed publisher
    ..DCM treated with adipose mesenchymal stem cells (MSC) alone or in combination with platelet-rich plasma (PRP)...
  30. Bessa M, Antunes S, Pereira R, Gonçalves F, Nunes B. Multibiomarker toxicity characterization of uranium mine drainages to the fish Carassius auratus. Environ Sci Pollut Res Int. 2016;23:13355-67 pubmed publisher
    ..24, and 48 h) to water from a pond (treatment pond (TP)) with a chemically treated effluent and a reference pond (PRP), in the vicinity of the Cunha Baixa uranium mine (Portugal)...
  31. Lamplot J, Angeline M, Angeles J, Beederman M, Wagner E, Rastegar F, et al. Distinct effects of platelet-rich plasma and BMP13 on rotator cuff tendon injury healing in a rat model. Am J Sports Med. 2014;42:2877-87 pubmed publisher
    Although platelet-rich plasma (PRP) is used clinically to augment tendon healing, bone morphogenetic protein-13 (BMP13) may provide a better therapeutic avenue to improve early tendon healing and repair...
  32. Wang K, Yang Z, Chiu A, Lin F, Rubenstein R. Examining the Neural and Astroglial Protective Effects of Cellular Prion Protein Expression and Cell Death Protease Inhibition in Mouse Cerebrocortical Mixed Cultures. Mol Neurobiol. 2016;53:4821-32 pubmed publisher
    Overexpression of cellular prion protein, PrP(C), has cytoprotective effects against neuronal injuries. Inhibition of cell death-associated proteases such as necrosis-linked calpain and apoptosis-linked caspase are also neuroprotective...
  33. Kanchanatawan W, Arirachakaran A, Chaijenkij K, Prasathaporn N, Boonard M, Piyapittayanun P, et al. Short-term outcomes of platelet-rich plasma injection for treatment of osteoarthritis of the knee. Knee Surg Sports Traumatol Arthrosc. 2016;24:1665-77 pubmed publisher
    ..Lequesne scores) and adverse events in the treatment of osteoarthritis (OA) of the knee with platelet-rich plasma (PRP) versus hyaluronic acid (HA) or placebo...
  34. Takase F, Inui A, Mifune Y, Sakata R, Muto T, Harada Y, et al. Effect of platelet-rich plasma on degeneration change of rotator cuff muscles: In vitro and in vivo evaluations. J Orthop Res. 2017;35:1806-1815 pubmed publisher
    Atrophy with fatty degeneration is often seen in rotator cuff muscles with torn tendons. PRP has been reported to enhance tissue repair processes after tendon ruptures...
  35. Usuelli F, Grassi M, Maccario C, Viganò M, Lanfranchi L, Alfieri Montrasio U, et al. Intratendinous adipose-derived stromal vascular fraction (SVF) injection provides a safe, efficacious treatment for Achilles tendinopathy: results of a randomized controlled clinical trial at a 6-month follow-up. Knee Surg Sports Traumatol Arthrosc. 2018;26:2000-2010 pubmed publisher
    Although platelet-rich plasma (PRP) injection has shown controversial results for the treatment of Achilles tendinopathy, it remains the most used biological treatment...
  36. Chung L, Gagnon J, Reid K. Amino acid sequence studies of human C4b-binding protein: N-terminal sequence analysis and alignment of the fragments produced by limited proteolysis with chymotrypsin and the peptides produced by cyanogen bromide treatment. Mol Immunol. 1985;22:427-35 pubmed
    Treatment of human C4b-binding protein (C4BP) with cyanogen bromide gave five major peptides and limited proteolysis with chymotrypsin yielded two fragments. The yields, apparent mol...
  37. Bencsik A, Baron T. Histopathological studies of "CH1641-like" scrapie sources versus classical scrapie and BSE transmitted to ovine transgenic mice (TgOvPrP4). PLoS ONE. 2011;6:e22105 pubmed publisher
    ..In addition to the conventional vacuolar lesion profile approach and PrP(d) brain mappings, an innovative differential PET-blot analysis was introduced to classify the different strains of ..
  38. Barba Recreo P, Del Castillo Pardo de Vera J, Georgiev Hristov T, Ruiz Bravo Burguillos E, Abarrategi A, Burgueño M, et al. Adipose-derived stem cells and platelet-rich plasma for preventive treatment of bisphosphonate-related osteonecrosis of the jaw in a murine model. J Craniomaxillofac Surg. 2015;43:1161-8 pubmed publisher
    ..ASCs) with or without previous stimulation with bone morphogenetic protein 2 (BMP-2) and platelet-rich plasma (PRP) in rats. Fifty-six male Wistar rats were treated with ZA for 9 weeks...
  39. Frid K, Binyamin O, Fainstein N, Keller G, Ben Hur T, Gabizon R. Autologous neural progenitor cell transplantation into newborn mice modeling for E200K genetic prion disease delays disease progression. Neurobiol Aging. 2018;65:192-200 pubmed publisher
    ..and gradually deteriorate to a terminal neurological condition concomitant with the accumulation of disease-related PrP. To investigate whether transplantation of neural progenitor cells (NPCs) to these mice can delay disease ..
  40. Tanaka Y, Hamamoto Y, Niyazi A, Nagasao T, Ueno M, Tabata Y. Effects of platelet-rich plasma on tissue-engineered vascularized flaps in an in vivo chamber. J Plast Reconstr Aesthet Surg. 2018;71:1062-1068 pubmed publisher
    ..b>PRP-induced inflammatory reactions were considered to be necessary to stimulate cell migration into the chamber, ..
  41. Margarit I, Bonacci S, Pietrocola G, Rindi S, Ghezzo C, Bombaci M, et al. Capturing host-pathogen interactions by protein microarrays: identification of novel streptococcal proteins binding to human fibronectin, fibrinogen, and C4BP. FASEB J. 2009;23:3100-12 pubmed publisher
    ..component named Fib and displayed differential binding capacities for fibronectin, fibrinogen, and C4BP. The protein regions involved in the interaction with each ligand were identified by constructing fragments of one ..
  42. Gough K, Rees H, Ives S, Maddison B. Methods for Differentiating Prion Types in Food-Producing Animals. Biology (Basel). 2015;4:785-813 pubmed publisher
    ..thought to be dictated mainly, if not solely, by the conformation of the disease form of the prion protein (PrP(Sc))...
  43. Castiblanco Valencia M, Fraga T, Pagotto A, Serrano S, Abreu P, Barbosa A, et al. Plasmin cleaves fibrinogen and the human complement proteins C3b and C5 in the presence of Leptospira interrogans proteins: A new role of LigA and LigB in invasion and complement immune evasion. Immunobiology. 2016;221:679-89 pubmed publisher
    ..interact with extracellular matrix components and complement regulators, including proteins of the FH family and C4BP. In this work, we demonstrate that these multifunctional molecules also bind plasminogen through both N- and C-..
  44. Taschieri S, Lolato A, Ofer M, Testori T, Francetti L, Del Fabbro M. Immediate post-extraction implants with or without pure platelet-rich plasma: a 5-year follow-up study. Oral Maxillofac Surg. 2017;21:147-157 pubmed publisher
    ..radiographic outcomes of immediate post-extraction implants with or without the use of pure platelet-rich plasma (P-PRP) in the short- and medium-term follow-up...
  45. Kizziah J, Manning K, Dearborn A, Wall E, Klenow L, Hill R, et al. Cleavage and Structural Transitions during Maturation of Staphylococcus aureus Bacteriophage 80? and SaPI1 Capsids. Viruses. 2017;9: pubmed publisher
    ..Both CP and SP of 80? are N-terminally processed by a host-encoded protease, Prp. We have analyzed phage mutants that express pre-cleaved or uncleavable versions of CP or SP, and show that the N-..
  46. Krueger C, Hoffman J, Balazs G, Johnson A, Potter B, Belmont P. Protected Resident Research Time Does Not Increase the Quantity or Quality of Residency Program Research Publications: A Comparison of 3 Orthopedic Residencies. J Surg Educ. 2017;74:264-270 pubmed publisher
    ..27) and per-resident (p = 0.80) basis. There were no residents at P3 who graduated without at least 1 PRP, whereas there were 7 residents from P1 and 8 residents from P2 who graduated without a PRP...
  47. Kupreishvili K, Meischl C, Vonk A, Stooker W, Eijsman L, Blom A, et al. Arterial Blood Pressure Induces Transient C4b-Binding Protein in Human Saphenous Vein Grafts. Ann Vasc Surg. 2017;41:259-264 pubmed publisher
    ..Here we have analyzed whether C4b-binding protein (C4bp), an endogenous complement inhibitor, is present in the vein wall...
  48. Urrea L, Segura Feliu M, Masuda Suzukake M, Hervera A, Pedraz L, García Aznar J, et al. Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons. Mol Neurobiol. 2018;55:1847-1860 pubmed publisher
    ..pathological spreading of α-synuclein can take place in the absence of Prnp, α-synuclein expanded faster in PrPC-overexpressing mice...
  49. Wang Y, Weng H, Zhang Y, Long Y, Li Y, Niu Y, et al. The PRR11-SKA2 Bidirectional Transcription Unit Is Negatively Regulated by p53 through NF-Y in Lung Cancer Cells. Int J Mol Sci. 2017;18: pubmed publisher
  50. Li X, Wu M, Liu G, Pei W, Zhai H, Yu J, et al. Identification of candidate genes for fiber length quantitative trait loci through RNA-Seq and linkage and physical mapping in cotton. BMC Genomics. 2017;18:427 pubmed publisher
    ..The candidate genes may serve as the foundation for further in-depth studies of the molecular mechanism of natural variation in fiber elongation. ..
  51. Abdulrahman B, Abdelaziz D, Thapa S, Lu L, Jain S, Gilch S, et al. The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions. Sci Rep. 2017;7:17565 pubmed publisher
    ..The autocatalytic conversion of the cellular prion protein (PrPC) into the pathologic isoform PrPSc is a key feature in prion pathogenesis...
  52. Hukema R, Buijsen R, Schonewille M, Raske C, Severijnen L, Nieuwenhuizen Bakker I, et al. Reversibility of neuropathology and motor deficits in an inducible mouse model for FXTAS. Hum Mol Genet. 2015;24:4948-57 pubmed publisher
    ..e. Tet-On mice). This Tet-On model makes use of the PrP-rtTA driver and allows us to study disease progression and possibilities of reversibility...
  53. Wang C, Lee C, Peng Y, Salter D, Lee H. Platelet-Rich Plasma Attenuates 30-kDa Fibronectin Fragment-Induced Chemokine and Matrix Metalloproteinase Expression by Meniscocytes and Articular Chondrocytes. Am J Sports Med. 2015;43:2481-9 pubmed publisher
    Proteolytic fragments of fibronectin have catabolic effects on cartilage and menisci. Platelet-rich plasma (PRP) is increasingly being used to treat a range of joint conditions, but it is unknown whether PRP influences fibronectin ..
  54. Dallari D, Stagni C, Rani N, Sabbioni G, Pelotti P, Torricelli P, et al. Ultrasound-Guided Injection of Platelet-Rich Plasma and Hyaluronic Acid, Separately and in Combination, for Hip Osteoarthritis: A Randomized Controlled Study. Am J Sports Med. 2016;44:664-71 pubmed publisher
    The effectiveness of intra-articular platelet-rich plasma (PRP) injections has been evaluated in knee chondroplasty and osteoarthritis (OA); however, little evidence of its efficacy in hip OA exists...
  55. Sivaprasad S, Prevost A, Vasconcelos J, Riddell A, Murphy C, Kelly J, et al. Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks (CLARITY): a multicentre, single-blinded, randomised, controlled, phase . Lancet. 2017;389:2193-2203 pubmed publisher
    ..Proliferative diabetic retinopathy has been managed by panretinal laser photocoagulation (PRP) for the past 40 years. We report the 1 year safety and efficacy of intravitreal aflibercept...
  56. Matsuguchi T, Okamura S, Aso T, Sata T, Niho Y. Molecular cloning of the cDNA coding for proline-rich protein (PRP): identity of PRP as C4b-binding protein. Biochem Biophys Res Commun. 1989;165:138-44 pubmed
    ..Furthermore, the reported molecular weights of the two proteins under both reduced and unreduced conditions were quite alike. These findings indicate that PRP is identical with C4bp.
  57. Mukherjee R, Chakrabarti O. Ubiquitin-mediated regulation of the E3 ligase GP78 by MGRN1 in trans affects mitochondrial homeostasis. J Cell Sci. 2016;129:757-73 pubmed publisher
    ..is important because functional depletion of MGRN1 by the membrane-associated disease-causing prion protein (Ctm)PrP affects polyubiquitylation and degradation of GP78, also leading to an increase in mitophagy events...
  58. Giudice G, Cutrignelli D, Leuzzi S, Robusto F, Sportelli P, Nacchiero E. Autologous bone grafting with platelet-rich plasma for alveolar cleft repair in patient with cleft and palate. Ann Ital Chir. 2016;87:5-12 pubmed
    ..The aim of this retrospective study was to evaluate the results of bone grafting in association with PRP (plateletrich plasma) to enhance osteogenesis and osteointegration...
  59. Han X, Luo J, Zhou W, Yang S, Yang M. Determination and pharmacokinetic properties of arsenic speciation in Xiao-Er-Zhi-Bao-Wan by high-performance liquid chromatography with inductively coupled plasma mass spectrometry. J Sep Sci. 2016;39:3852-3859 pubmed publisher
    A method of high performance liquid chromatography with a Hamilton PRP-X100 ion-exchange column (250 × 4...
  60. Nakatani Y, Agata H, Sumita Y, Koga T, Asahina I. Efficacy of freeze-dried platelet-rich plasma in bone engineering. Arch Oral Biol. 2017;73:172-178 pubmed publisher
    Platelet-rich plasma (PRP) is typically isolated and applied immediately after preparation, making it both a time- and labor-intensive addition to the operative procedure. Thus, it would be convenient if PRP could be preserved...
  61. Gwinner C, Gerhardt C, Haneveld H, Scheibel M. Two-staged application of PRP in arthroscopic rotator cuff repair: a matched-pair analysis. Arch Orthop Trauma Surg. 2016;136:1165-71 pubmed publisher
    ..The purpose of this study is to evaluate the clinical and structural outcomes of repeated PRP application on rotator cuff repair...
  62. Bender H, Kane S, Zabel M. Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes. J Vis Exp. 2016;: pubmed publisher
    Prion diseases result from the misfolding of the normal, cellular prion protein (PrP(C)) to an abnormal protease resistant isomer called PrP(Res)...
  63. Zhou Y, Zhang J, Yang J, Narava M, Zhao G, Yuan T, et al. Kartogenin with PRP promotes the formation of fibrocartilage zone in the tendon-bone interface. J Tissue Eng Regen Med. 2017;11:3445-3456 pubmed publisher
    ..In this study, we used a compound called kartogenin (KGN) with platelet-rich plasma (PRP) to induce the formation of fibrocartilage zone in a rat tendon graft-bone tunnel model...
  64. Yang X, Cheng Z, Zhang L, Wu G, Shi R, Gao Z, et al. Prion Protein Family Contributes to Tumorigenesis via Multiple Pathways. Adv Exp Med Biol. 2017;1018:207-224 pubmed publisher
    A wealth of evidence suggests that proteins from prion protein (PrP) family contribute to tumorigenesis in many types of cancers, including pancreatic ductal adenocarcinoma (PDAC), breast cancer, glioblastoma, colorectal cancer, gastric ..
  65. Xu Q, Li B, Yuan L, Dong Z, Zhang H, Wang H, et al. Combination of platelet-rich plasma within periodontal ligament stem cell sheets enhances cell differentiation and matrix production. J Tissue Eng Regen Med. 2017;11:627-636 pubmed publisher
    The longstanding goal of periodontal therapy is to regenerate periodontal tissues. Although platelet-rich plasma (PRP) has been gaining increasing popularity for use in the orofacial region, whether PRP is useful for periodontal ..
  66. Kane J, Costanzo J, Raikin S. The Efficacy of Platelet-Rich Plasma for Incision Healing After Total Ankle Replacement Using the Agility Total Ankle Replacement System. Foot Ankle Int. 2016;37:373-7 pubmed publisher
    The use of platelet-rich plasma (PRP) to aid in healing of operative incisions has been well documented in the literature. Most studies have been conducted retrospectively with small sample sizes and are conflicting in their outcomes...
  67. Beckman D, Linden R. A roadmap for investigating the role of the prion protein in depression associated with neurodegenerative disease. Prion. 2016;10:131-42 pubmed publisher
    The physiological properties of the native, endogenous prion protein (PrP(C)) is a matter of concern, due to its pleiotropic functions and links to neurodegenerative disorders and cancer...
  68. Omatsu Kanbe M, Nozuchi N, Nishino Y, Mukaisho K, Sugihara H, Matsuura H. Identification of cardiac progenitors that survive in the ischemic human heart after ventricular myocyte death. Sci Rep. 2017;7:41318 pubmed publisher
    ..ACMs" are found as small interstitial cells among ventricular myocytes that co-express cellular prion protein (PrP) and cardiac troponin T (cTnT) in mouse and human heart tissues...
  69. Al Dabbagh M, Salim N, Himmat M, Ahmed A, Saeed F. Quantum probability ranking principle for ligand-based virtual screening. J Comput Aided Mol Des. 2017;31:365-378 pubmed publisher
    ..compounds databases in decreasing probability of biological activity based upon probability ranking principle (PRP)...
  70. Decco O, Beltrán V, Zuchuat J, Cura A, Lezcano M, Engelke W. Bone Augmentation in Rabbit Tibia Using Microfixed Cobalt-Chromium Membranes with Whole Blood and Platelet-Rich Plasma. Materials (Basel). 2015;8:4843-4856 pubmed publisher
    ..barrier membranes were placed on six adult Fauve de Bourgogne rabbits, divided into two groups: whole blood and PRP. Three densitometric controls were performed during the experiment...
  71. Lee S, Lim Y, Lew D, Song S. Salvage of Unilateral Complete Ear Amputation with Continuous Local Hyperbaric Oxygen, Platelet-Rich Plasma and Polydeoxyribonucleotide without Micro-Revascularization. Arch Plast Surg. 2017;44:554-558 pubmed publisher
    ..a postoperative salvage course including continuous local hyperbaric oxygen therapy (HBOT), platelet-rich plasma (PRP) injections, and polydeoxyribonucleotide (PDRN) injections...
  72. Jeong W, Roh T, Kim Y, Kang E, Jung B, Lee W, et al. Acceleration of osteogenesis by platelet-rich plasma with acellular dermal matrix in a calvarial defect model. Childs Nerv Syst. 2016;32:1653-9 pubmed publisher
    The effects of platelet-rich plasma (PRP) on improvement of bone regeneration have been widely investigated. However, use of a proper scaffold is also important to the delivery of bioactive materials...
  73. Chen X, Fan X, Tan J, Shi P, Wang X, Wang J, et al. Palladin is involved in platelet activation and arterial thrombosis. Thromb Res. 2017;149:1-8 pubmed publisher
    ..platelets on immobilized fibrinogen (Fg) and increased rate of clot retraction in platelet-rich plasma (PRP) containing palladin+/- platelets...
  74. Domingues P, Nanduri L, Seget K, Venkateswaran S, Agorku D, Viganó C, et al. Cellular Prion Protein PrPC and Ecto-5'-Nucleotidase Are Markers of the Cellular Stress Response to Aneuploidy. Cancer Res. 2017;77:2914-2926 pubmed publisher
    ..identified with altered expression in aneuploid cells, including overexpression of the cellular prion protein CD230/PrPC and the immunosuppressive cell surface enzyme ecto-5'-nucleotidase CD73...
  75. Makarava N, Savtchenko R, Baskakov I. Methods of Protein Misfolding Cyclic Amplification. Methods Mol Biol. 2017;1658:169-183 pubmed publisher
    ..rely on PMCAb for assessing strain-specific prion amplification rates, for selective amplification of subtypes of PrPSc from a mixture, and a PMCAb approach that can replace animal titration of scrapie material...
  76. Carmona J, Ríos D, López C, Alvarez M, Pérez J, Bohórquez M. In vitro effects of platelet-rich gel supernatants on histology and chondrocyte apoptosis scores, hyaluronan release and gene expression of equine cartilage explants challenged with lipopolysaccharide. BMC Vet Res. 2016;12:135 pubmed publisher
    Platelet-rich plasma (PRP) preparations are a common treatment in equine osteoarthritis (OA)...
  77. Elnehrawy N, Ibrahim Z, Eltoukhy A, Nagy H. Assessment of the efficacy and safety of single platelet-rich plasma injection on different types and grades of facial wrinkles. J Cosmet Dermatol. 2017;16:103-111 pubmed publisher
    Platelet-rich plasma (PRP) is considered as a growing modality for tissue regeneration and a developing research area for clinicians and researchers...
  78. Kraus A, Raymond G, Race B, Campbell K, Hughson A, Anson K, et al. PrP P102L and Nearby Lysine Mutations Promote Spontaneous In Vitro Formation of Transmissible Prions. J Virol. 2017;91: pubmed publisher
    ..and pathogenic in vivo To probe the structural features that confer transmissibility to prion protein (PrP) fibrils, we have analyzed synthetic PrP amyloids with or without the human prion disease-associated P102L mutation...
  79. Burke R, Lighthouse J, Quijada P, Dirkx R, Rosenberg A, Moravec C, et al. Small proline-rich protein 2B drives stress-dependent p53 degradation and fibroblast proliferation in heart failure. Proc Natl Acad Sci U S A. 2018;115:E3436-E3445 pubmed publisher
    ..These data establish SPRR2B as a unique component of the USP7/MDM2 ubiquitination complex that drives p53 degradation, CF accumulation, and the development of pathological cardiac fibrosis. ..
  80. Wang H, Tian C, Sun J, Chen L, Lv Y, Yang X, et al. Overexpression of PLK3 Mediates the Degradation of Abnormal Prion Proteins Dependent on Chaperone-Mediated Autophagy. Mol Neurobiol. 2017;54:4401-4413 pubmed publisher
    ..Previous work also showed the regulatory activity of exogenous PLK3 on the degradation of PrP (prion protein) mutants and pathogenic PrPSc; however, the precise mechanisms remain unknown...
  81. Hara T, Kakudo N, Morimoto N, Ogawa T, Lai F, Kusumoto K. Platelet-rich plasma stimulates human dermal fibroblast proliferation via a Ras-dependent extracellular signal-regulated kinase 1/2 pathway. J Artif Organs. 2016;19:372-377 pubmed
    Platelet-rich plasma (PRP) contains a high concentration of several growth factors and contributes to soft-tissue engineering and wound healing. However, the effect of PRP on human dermal fibroblast proliferation and responses is unknown...
  82. Stambolsky C, Rodríguez Benítez S, Gutierrez Perez J, Torres Lagares D, Martín González J, Segura Egea J. Histologic characterization of regenerated tissues after pulp revascularization of immature dog teeth with apical periodontitis using tri-antibiotic paste and platelet-rich plasma. Arch Oral Biol. 2016;71:122-128 pubmed publisher
    ..with a different treatment protocol: A1, sodium hypochlorite (SH)+blood clot (BC); A2, SH+platelet-rich plasma (PRP); B1, SH+modified tri-antibiotic paste (mTAP)+BC; B2, SH+mTAP+PRP...
  83. Simmons M, Chaplin M, Konold T, Casalone C, Beck K, Thorne L, et al. L-BSE experimentally transmitted to sheep presents as a unique disease phenotype. Vet Res. 2016;47:112 pubmed
    ..b>PrP accumulation is confined to the nervous system, with the exception of one animal with lymphoreticular involvement...
  84. Panes O, Gonzalez C, Hidalgo P, Valderas J, Acevedo M, Contreras S, et al. Platelet tissue factor activity and membrane cholesterol are increased in hypercholesterolemia and normalized by rosuvastatin, but not by atorvastatin. Atherosclerosis. 2017;257:164-171 pubmed publisher
    ..Platelets from HC-patients were not hyper-responsive to low concentrations of classical agonists and had normal PRP-ETP, before and after statin administration...
  85. Picard F, Hersant B, Niddam J, Meningaud J. Injections of platelet-rich plasma for androgenic alopecia: A systematic review. J Stomatol Oral Maxillofac Surg. 2017;118:291-297 pubmed publisher
    The aim of this literature review was to evaluate the effects of PRP injections into the scalp of patients with androgenic alopecia...
  86. Rosskopf U, Daas A, Terao E, von Hunolstein C. Collaborative study on saccharide quantification of the Haemophilus influenzae type b component in liquid vaccine presentations. Pharmeur Bio Sci Notes. 2017;2017:44-68 pubmed
    ..onto the market, it must be demonstrated that the total and free polysaccharide (poly ribosyl-ribitol-phosphate, PRP) content of Haemophilus influenzae type b (Hib) vaccine complies with requirements...
  87. Ciccotosto G, Jana M, Cappai R. Neurotoxicity of Prion Peptides on Cultured Cerebellar Neurons. Methods Mol Biol. 2017;1658:147-165 pubmed publisher
    Prion neurotoxicity has been modeled in vitro using synthetic peptides derived from the PrPC sequence. The major region of neurotoxicity has been localized to the hydrophobic domain located in the middle of the PrP protein...
  88. Behzadi E, Hosseini H, Halabian R, Fooladi A. Macrophage cell-derived exosomes/staphylococcal enterotoxin B against fibrosarcoma tumor. Microb Pathog. 2017;111:132-138 pubmed publisher
    ..lysate treated EXO (EXOHSP70), Naloxone (NLX) treated EXO (EXONLX), Propranolol (PRP) treated EXO (EXOPRP) and staphylococcal enterotoxin B (SEB) anchored to three kinds of EXOs designated ..
  89. Yamasaki T, Suzuki A, Hasebe R, Horiuchi M. Flow Cytometric Detection of PrPSc in Neurons and Glial Cells from Prion-Infected Mouse Brains. J Virol. 2018;92: pubmed publisher
    In prion diseases, an abnormal isoform of prion protein (PrPSc) accumulates in neurons, astrocytes, and microglia in the brains of animals affected by prions...
  90. Fiorini M, Bongianni M, Monaco S, Zanusso G. Biochemical Characterization of Prions. Prog Mol Biol Transl Sci. 2017;150:389-407 pubmed publisher
    ..spongiform encephalopathies are characterized by the presence of the abnormal form of the prion protein (PrPSc)...
  91. Malahias M, Nikolaou V, Johnson E, Kaseta M, Kazas S, Babis G. Platelet-rich plasma ultrasound-guided injection in the treatment of carpal tunnel syndrome: A placebo-controlled clinical study. J Tissue Eng Regen Med. 2017;: pubmed publisher
    The purpose of this study is to demonstrate whether and to what extent a single injection of platelet-rich plasma (PRP), under ultrasound guidance, can improve the clinical symptoms of patients with a mild to moderate carpal tunnel ..
  92. Yang H, Pan L, Xu C, Zhang Y, Li K, Chen S, et al. Overexpression of tumor suppressor gene ZNF750 inhibits oral squamous cell carcinoma metastasis. Oncol Lett. 2017;14:5591-5596 pubmed publisher
    ..Overexpression of ZNF750 in CAL-27 cells resulted in inhibition of cell invasion and migration. Taken together, these data suggest that ZNF750 may inhibit the metastasis of OSCC...