Gene Symbol: C1S
Description: complement C1s
Alias: EDSPD2, complement C1s subcomponent, C1 esterase, basic proline-rich peptide IB-1, complement component 1 subcomponent s, complement component 1, s subcomponent
Species: human
Products:     C1S

Top Publications

  1. Abe C, Inoue T, Inglis M, Viar K, Huang L, Ye H, et al. C1 neurons mediate a stress-induced anti-inflammatory reflex in mice. Nat Neurosci. 2017;20:700-707 pubmed publisher
    ..Overall, acute stress attenuated IRI by activating a cholinergic, predominantly sympathetic, anti-inflammatory pathway. C1s were necessary and sufficient to mediate this effect.
  2. Wang H, Li N, Zhu C, Shi S, Jin H, Wang S. Anti-complementary activity of two homogeneous polysaccharides from Eclipta prostrata. Biochem Biophys Res Commun. 2017;493:887-893 pubmed publisher
    ..Preliminary mechanism study indicated that both EAP20-1 and EAP20-2 inhibited the activation of the complement system by interacting with C1q, C1r, C1s, C2, C4, C5, C7, and C9 components.
  3. Sato T, Iyama S, Murase K, Kamihara Y, Ono K, Kikuchi S, et al. Novel missense mutation in the TMPRSS6 gene in a Japanese female with iron-refractory iron deficiency anemia. Int J Hematol. 2011;94:101-103 pubmed publisher
    ..paper, we describe the first case of a Japanese female with IRIDA, who carried a novel mutation (K253E) in the CUB (complement factor C1r/C1s, urchin embryonic growth factor and bone morphogenetic protein 1) domain of the TMPRSS6 gene.
  4. Chen M, Wu J, Shi S, Chen Y, Wang H, Fan H, et al. Structure analysis of a heteropolysaccharide from Taraxacum mongolicum Hand.-Mazz. and anticomplementary activity of its sulfated derivatives. Carbohydr Polym. 2016;152:241-252 pubmed publisher
    ..42±0.22?g/mL). Mechanism studies indicated that Sul-DPSW-A inhibited complement activation by blocking C1q, C1r, C1s, and C9, but not C2, C3, C4, and C5. In addition, Sul-DPSW-A displayed limited anticoagulant effects...
  5. Ugurlar D, Howes S, de Kreuk B, Koning R, de Jong R, Beurskens F, et al. Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement. Science. 2018;359:794-797 pubmed publisher
    ..The data suggest that C1r may activate C1s within single, strained C1 complexes or between neighboring C1 complexes on surfaces.
  6. Berentsen S. How I manage patients with cold agglutinin disease. Br J Haematol. 2018;181:320-330 pubmed publisher
    ..Therapies targeting the classical complement pathway are promising, and the complement C1s inhibitor, BIVV009, has shown favourable results in preliminary studies.
  7. Berentsen S. Cold agglutinin disease. Hematology Am Soc Hematol Educ Program. 2016;2016:226-231 pubmed
    ..Rituximab-bendamustine is still an investigational therapy. Although complement-modulating agents are still to be considered experimental in CAD, therapy with the anti-C1s monoclonal antibody TNT009 seems promising.
  8. Yang Y, Guo J, Zhou X, Liu Z, Wang C, Wang K, et al. A novel cold atmospheric pressure air plasma jet for peri-implantitis treatment: An in vitro study. Dent Mater J. 2017;: pubmed publisher
    ..Moreover, XPS results demonstrated that the C1s peak was reduced and N1s and O1s peaks were obviously improved...
  9. Sourkova H, Primc G, Spatenka P. Surface Functionalization of Polyethylene Granules by Treatment with Low-Pressure Air Plasma. Materials (Basel). 2018;11: pubmed publisher
    ..The high-resolution C1s peaks revealed formation of various functional groups rather independently from treatment parameters...

More Information

Publications153 found, 100 shown here

  1. Ghannam A, Sellier P, Fain O, Martin L, Ponard D, Drouet C. C1 Inhibitor as a glycoprotein: The influence of polysaccharides on its function and autoantibody target. Mol Immunol. 2016;71:161-165 pubmed publisher
    ..with O-linked polysaccharides, but not with N-linked polysaccharides, in controlling the contact phase but not C1s target, thus indicating the N-terminal domain's involvement in C1Inh function...
  2. Atzei D, Fermo P, Vecchi R, Fantauzzi M, Comite V, Valli G, et al. Composition and origin of PM2.5 in Mediterranean Countryside. Environ Pollut. 2019;246:294-302 pubmed publisher
    ..Among the components of XPS C1s signals recorded on the samples collected during winter, it was found that the signal at 286...
  3. Xie C, Yang S, Li B, Wang H, Shi J, Li G, et al. C-doped mesoporous anatase TiO2 comprising 10nm crystallites. J Colloid Interface Sci. 2016;476:1-8 pubmed publisher
    ..XPS analysis showed a relatively strong C1s peak at 288...
  4. Lu M, Ohba T, Kaneko K, Hata K, Yumura M, Iijima S, et al. Electron Density Modification of Single Wall Carbon Nanotubes (SWCNT) by Liquid-Phase Molecular Adsorption of Hexaiodobenzene. Materials (Basel). 2013;6:535-543 pubmed publisher
    ..The charge transfer from SWCNT to HIB was further confirmed by the change in the C1s peak of X-ray photoelectron spectrum, revealing the oxidation of carbon in SWCNT upon HIB adsorption.
  5. Kowalewska A, Nowacka M, Tracz A, Makowski T. Supramolecular self-assembly of linear oligosilsesquioxanes on mica--AFM surface imaging and hydrophilicity studies. Soft Matter. 2015;11:4818-29 pubmed publisher
    ..Comparative height profile analysis combined with ATR-FTIR studies of the spectral regions characteristic of carboxylic groups and C1s core level envelope by XPS confirmed specific interactions between LPSQ-COOH and mica.
  6. Kahk J, Lischner J. Core electron binding energies of adsorbates on Cu(111) from first-principles calculations. Phys Chem Chem Phys. 2018;20:30403-30411 pubmed publisher
    ..we calculate core-level binding energy shifts for a series of adsorbates on Cu(111) and show that the resulting C1s and O1s binding energy shifts for adsorbed CO, CO2, C2H4, HCOO, CH3O, H2O, OH, and a surface oxide on Cu(111) are ..
  7. Guo J, Gao Y, Wang Y, Zou Y, Du Y, Luo C, et al. Investigation of C1-complex regions reveals new C1Q variants associated with protection from systemic lupus erythematosus, and affect its transcript abundance. Sci Rep. 2018;8:8048 pubmed publisher
    ..Furthermore, there are no reports concerning polymorphisms of C1S, C1R, and C1RL and whether they confer susceptibility to SLE...
  8. Inouye K, Tsuzuki S, Yasumoto M, Kojima K, Mochida S, Fushiki T. Identification of the matriptase second CUB domain as the secondary site for interaction with hepatocyte growth factor activator inhibitor type-1. J Biol Chem. 2010;285:33394-403 pubmed publisher
    ..of matriptase comprises a noncatalytic stem domain (containing two tandem repeats of complement proteases C1r/C1s-urchin embryonic growth factor-bone morphogenetic protein (CUB) domain) and a catalytic serine protease domain...
  9. Uekita T, Fujii S, Miyazawa Y, Hashiguchi A, Abe H, Sakamoto M, et al. Suppression of autophagy by CUB domain-containing protein 1 signaling is essential for anchorage-independent survival of lung cancer cells. Cancer Sci. 2013;104:865-70 pubmed publisher
    CUB (C1r/C1s, urchin embryonic growth factor, BMP1) domain-containing protein 1 (CDCP1) has been implicated in promoting metastasis of cancer cells through several mechanisms, including the inhibition of anoikis, which is cell death ..
  10. Gonzalez Muniesa P, Marrades M, Martinez J, Moreno Aliaga M. Differential proinflammatory and oxidative stress response and vulnerability to metabolic syndrome in habitual high-fat young male consumers putatively predisposed by their genetic background. Int J Mol Sci. 2013;14:17238-55 pubmed publisher
    ..Genes involved in inflammation (ALCAM, CTSB, C1S, YKL-40, MIF, SAA2), extracellular matrix remodeling (MMP9, PALLD), angiogenesis (EGFL6, leptin) and oxidative ..
  11. Céolin D, Liu J, Vaz da Cruz V, Agren H, Journel L, Guillemin R, et al. Recoil-induced ultrafast molecular rotation probed by dynamical rotational Doppler effect. Proc Natl Acad Sci U S A. 2019;116:4877-4882 pubmed publisher
    ..As a showcase, this was performed by hard X-ray C1s ionization of carbon monoxide accompanied by spinning up the molecule via the recoil "kick" of the emitted fast ..
  12. Mitra M, Mahapatra M, Dutta A, Roy J, Karmakar M, Deb M, et al. Carbohydrate and collagen-based doubly-grafted interpenetrating terpolymer hydrogel via N-H activated in situ allocation of monomer for superadsorption of Pb(II), Hg(II), dyes, vitamin-C, and p-nitrophenol. J Hazard Mater. 2018;369:746-762 pubmed publisher
    ..analyses of unadsorbed- and/or adsorbed-GGTPCBD using FTIR, 1H/13C NMR, O1s-/N1s-/C1s-/Pb4f7/2,5/2-/Hg4f7/2,5/2-XPS, UV-vis, TGA, DSC, XRD, DLS, SEM, EDX, % gel content, % -COOH, ..
  13. Almlöf J, Nystedt S, Leonard D, Eloranta M, Grosso G, Sjöwall C, et al. Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus. Hum Genet. 2019;138:141-150 pubmed publisher
    ..We also identified seven ultra-rare, coding heterozygous variants in five genes (C1S, DNASE1L3, DNASE1, IFIH1, and RNASEH2A) involved in monogenic SLE...
  14. Lin J, Hu J, Zhang J, Wang S, Ma Y, Song X. Electronic structures and spectral characteristics of the six C32 fullerene isomers. Spectrochim Acta A Mol Biomol Spectrosc. 2019;212:180-187 pubmed publisher
    ..For the discernment, geometry optimizations of the six isomers have been carried out, and the C1s XPS and NEXAFS spectra have been simulated in the frame of density functional theory (DFT)...
  15. Gorbushin A. Derivatives of the lectin complement pathway in Lophotrochozoa. Dev Comp Immunol. 2019;94:35-58 pubmed publisher
    ..common ancestor of TEP-associated proteases (C2/Bf/Сf/Lf), the common ancestor of MASP-like proteases (MASP/C1r/C1s, MReM1/MReM2) and multimeric recognition proteins (C1q-, MBL- and FCN-homologs)...
  16. Oku T, Kurisaka C, Ando Y, Tsuji T. Identification of human plasma C1 inhibitor as a target protein for staphylococcal superantigen-like protein 5 (SSL5). Biochem Biophys Res Commun. 2018;: pubmed publisher
    ..was found to attenuate the inhibitory activity of recombinant histidine-tagged C1Inh (C1Inh-His) toward complement C1s. We also observed that the treatment of C1Inh-His with neuraminidase markedly decreased its binding to GST-SSL5...
  17. Saravanakumar K, Shanmugam S, Varukattu N, Mubarakali D, Kathiresan K, Wang M. Biosynthesis and characterization of copper oxide nanoparticles from indigenous fungi and its effect of photothermolysis on human lung carcinoma. J Photochem Photobiol B. 2019;190:103-109 pubmed publisher
    ..The survey-scan spectrum of XPS indicated the presence of C1s (47.83%), Cu2p (16.11%), Na1s (2.2%) and O1s (33.86%)...
  18. Thomas K, Valenzuela N, Gjertson D, Mulder A, Fishbein M, Parry G, et al. An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA. Am J Transplant. 2015;15:2037-49 pubmed publisher
    ..We characterized the ability of an anti-C1s monoclonal antibody, TNT003, to inhibit HLA antibody (HLA-Ab)-induced complement activation...
  19. Jager U, D Sa S, Schörgenhofer C, Bartko J, Derhaschnig U, Sillaber C, et al. Inhibition of complement C1s improves severe hemolytic anemia in cold agglutinin disease: a first-in-human trial. Blood. 2018;: pubmed publisher
    ..This trial tested the hypothesis that the anti-C1s antibody sutimlimab would ameliorate hemolytic anemia...
  20. Robin J, Ludlow A, Batten K, Magdinier F, Stadler G, Wagner K, et al. Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances. Genes Dev. 2014;28:2464-76 pubmed publisher
    ..We report three genes (ISG15 [interferon-stimulated gene 15 kd], DSP [Desmoplakin], and C1S [complement component 1s subcomplement]) located at three different subtelomeric ends (1p, 6p, and 12p) whose ..
  21. Jin Y, Zhao C, Chen L, Liu X, Pan S, Ju D, et al. Identification of novel gene and pathway targets for human epilepsy treatment. Biol Res. 2016;49:3 pubmed publisher
    ..In down-co-expression module, C1QB (complement C1s), C1S (complement component 1, S subcomponent) and CFI (complement factor I) were enriched in GO:0006955 ~ ..
  22. Silva Moraes M, Garcia Basabe Y, de Souza R, Mota A, Passos R, Galante D, et al. Geometry-dependent DNA-TiO2 immobilization mechanism: A spectroscopic approach. Spectrochim Acta A Mol Biomol Spectrosc. 2018;199:349-355 pubmed publisher
    ..The analysis of photoabsorption spectra at C1s edge revealed that the molecular groups that participate in the C1s→LUMO electronic transitions have ..
  23. Kaplan A, Joseph K. Complement, Kinins, and Hereditary Angioedema: Mechanisms of Plasma Instability when C1 Inhibitor is Absent. Clin Rev Allergy Immunol. 2016;51:207-15 pubmed publisher
    ..Purified C1r auto-activates in physiologic buffers, activates C1s, which in turn depletes C4. This occurs when C1 inhibitor is deficient...
  24. Lee S, Kim K, Joo K, Kim J. Angiogenin ameliorates corneal opacity and neovascularization via regulating immune response in corneal fibroblasts. BMC Ophthalmol. 2016;16:57 pubmed publisher
    ..levels of IL-1?, IL-6, IL-8, TNF-? receptor (TNFR)1, 2, TLR4, MYD88, and complement components except for C1r and C1s and elevated the mRNA expression of IL-4 and IL-10...
  25. Mortensen S, Sander B, Jensen R, Pedersen J, Golas M, Jensenius J, et al. Structure and activation of C1, the complex initiating the classical pathway of the complement cascade. Proc Natl Acad Sci U S A. 2017;114:986-991 pubmed publisher
    ..packed together in the center of C1 and an intricate intramolecular reaction mechanism for activation of C1r and C1s, induced upon C1 binding to the activator...
  26. Yao S, Ng A, Cass C, Young J. Role of cysteine 416 in N-ethylmaleimide sensitivity of human equilibrative nucleoside transporter 1 (hENT1). Biochem J. 2018;475:3293-3309 pubmed publisher
    ..We then tested NEM sensitivity of recombinant wild-type hENT1, hENT1 mutants C1S to C10S (single cysteine residues replaced by serine), hENT1C- (all cysteine residues replaced by serine), and ..
  27. Waldner A, Artiglia L, Kong X, Orlando F, Huthwelker T, Ammann M, et al. Pre-melting and the adsorption of formic acid at the air-ice interface at 253 K as seen by NEXAFS and XPS. Phys Chem Chem Phys. 2018;20:24408-24417 pubmed publisher
    ..Electron kinetic energy dependent C1s photoemission data indicate that, at low coverage of a few 1014 molecules cm-2, the presence ..
  28. Malfait F. Vascular aspects of the Ehlers-Danlos Syndromes. Matrix Biol. 2018;71-72:380-395 pubmed publisher
    ..epimerase (DSE)), (putative) transcription factors (ZNF469, PRDM5), components of the complement pathway (C1r, C1s) and an intracellular Zinc transporter (ZIP13)...
  29. Sönmez E, Turkdogan K, Karabacak M, Civelek C, Yilmaz C, Ozer O, et al. The diagnostic role of signal peptide-C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 in non-ST-elevation acute coronary syndrome. Am J Emerg Med. 2015;33:21-4 pubmed publisher
    ..Signal peptide-C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 (SCUBE1) is stored within the α granules of ..
  30. Muia J, Zhu J, Gupta G, Haberichter S, Friedman K, Feys H, et al. Allosteric activation of ADAMTS13 by von Willebrand factor. Proc Natl Acad Sci U S A. 2014;111:18584-9 pubmed publisher
    ..Another seven T and two complement C1r/C1s, sea urchin epidermal growth factor, and bone morphogenetic protein (CUB) domains of uncertain function are C-..
  31. Grenier E, Gehin C, McAdams E, Lun B, Gobin J, Uhl J. Effect of compression stockings on cutaneous microcirculation: Evaluation based on measurements of the skin thermal conductivity. Phlebology. 2016;31:101-5 pubmed publisher
    ..aged 42 years ±2 years, who suffer from minor symptoms of chronic venous disease, classified as C0s, and C1s (CEAP)...
  32. Chou C, Li Y, Chang C, Yang C, Li P, Jeng Y, et al. Prognostic Significance of CDCP1 Expression in Colorectal Cancer and Effect of Its Inhibition on Invasion and Migration. Ann Surg Oncol. 2015;22:4335-43 pubmed publisher
    To assess the correlations and functions of complement C1r/C1s, Uegf, Bmp1 domain-containing protein-1 (CDCP1) in identifying colorectal cancer (CRC) patients who are at high risk for metastasis...
  33. Engel R, Rensink I, Roem D, Brouwer M, Kalei A, Perry D, et al. ELISA to measure neutralizing capacity of anti-C1-inhibitor antibodies in plasma of angioedema patients. J Immunol Methods. 2015;426:114-9 pubmed publisher
    ..The ELISA is based on the specific interaction of active C1-inh with its target protease C1s. Decrease in the amount of C1s bound to immobilized C1-inh in the presence of test samples is proportional to the ..
  34. Chen J, Yu Q, Zhu Z, Peng Y, Fang F. Spatial summation revealed in the earliest visual evoked component C1 and the effect of attention on its linearity. J Neurophysiol. 2016;115:500-9 pubmed publisher
    ..the amplitude of the C1 evoked by the three-grating stimulus roughly equaled the sum of the amplitudes of the C1s evoked by its two components, regardless of the distances between these gratings...
  35. Hulme C, Wilson E, Fuller H, Roberts S, Richardson J, Gallacher P, et al. Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation. Arthritis Res Ther. 2018;20:87 pubmed publisher
    ..The differential expression of two proteins (complement C1s subcomponent and matrix metalloproteinase 3) was confirmed biochemically...
  36. Franchi S, Secchi V, Santi M, Dettin M, Zamunér A, Battocchio C, et al. Biofunctionalization of TiO2 surfaces with self-assembling oligopeptides in different pH and Ionic Strength conditions: Charge effects and molecular organization. Mater Sci Eng C Mater Biol Appl. 2018;90:651-656 pubmed publisher
    ..XPS at the C1s, N1s, O1s core levels allowed to study surfaces and biomolecule/substrate interfaces...
  37. Wang H, Xue Z, Liu Z, Wang W, Wang F, Wang Y, et al. A novel C-type lectin from the sea cucumber Apostichopus japonicus (AjCTL-2) with preferential binding of d-galactose. Fish Shellfish Immunol. 2018;79:218-227 pubmed publisher
    ..It contained a canonical signal peptide at the N-terminus, a low density lipoprotein receptor class A (LDLa), a C1r/C1s/Uegf/bone morphogenetic protein 1 (CUB), and a CRD with two motifs Glu-Pro-Asn (EPN) and Trp-Asn-Asp (WND) in Ca<..
  38. Derhaschnig U, Gilbert J, Jager U, Bohmig G, Stingl G, Jilma B. Combined integrated protocol/basket trial design for a first-in-human trial. Orphanet J Rare Dis. 2016;11:134 pubmed
    ..placebo-controlled first-in-human study with TNT009, which is a humanized monoclonal antibody directed against the C1s subunit of human complement component C1...
  39. Bogachev V, Boldin B, Turkin P. Administration of Micronized Purified Flavonoid Fraction During Sclerotherapy of Reticular Veins and Telangiectasias: Results of the National, Multicenter, Observational Program VEIN ACT PROLONGED-C1. Adv Ther. 2018;35:1001-1008 pubmed publisher
    ..In a national, multicenter, observational program, physicians recruited CEAP C1s patients scheduled for sclerotherapy...
  40. Yamahata H, Niiro T, Mori M, Yamaguchi S, Yonenaga M, Sugata J, et al. Is the atlas size associated with the pathophysiology of symptomatic spinal canal stenosis at the C1 level?. J Clin Neurosci. 2018;57:58-62 pubmed publisher
    ..We investigated the characteristics of patients with C1 stenosis (C1S) with special reference to the size of the atlas...
  41. Vinoth R, Karthik P, Muthamizhchelvan C, Neppolian B, Ashokkumar M. Carrier separation and charge transport characteristics of reduced graphene oxide supported visible-light active photocatalysts. Phys Chem Chem Phys. 2016;18:5179-91 pubmed publisher
    ..The low intense oxygen functionalities (C-O-C and COOH groups) peak observed in the high resolution C1s spectrum of a hybrid AgI-mesoTiO2-rGO photocatalyst clearly confirmed the successful reduction of graphene oxide (..
  42. Gao Z, Li M, Ma J, Zhang S. An amphioxus gC1q protein binds human IgG and initiates the classical pathway: Implications for a C1q-mediated complement system in the basal chordate. Eur J Immunol. 2014;44:3680-95 pubmed publisher
    ..Moreover, rBjC1q can assemble to form the high molecular weight oligomers necessary for binding to proteases C1r/C1s and for complement activation, and binds human C1r/C1s/mannan-binding lectin-associated serine protease-2 as well ..
  43. Sanfilippo C, Longo A, Lazzara F, Cambria D, Distefano G, Palumbo M, et al. CHI3L1 and CHI3L2 overexpression in motor cortex and spinal cord of sALS patients. Mol Cell Neurosci. 2017;85:162-169 pubmed publisher
    ..Furthermore, we found that four genes belonging to the Chitinases network (SERPINA3, C1s, RRAD, HLA-DQA1) were significantly upregulated in the motor cortex of sALS patients and positively correlated with ..
  44. Filippi A, Fraschetti C, Grandinetti F, Speranza M, Ponzi A, Decleva P, et al. Electronic structure and conformational flexibility of D-cycloserine. Phys Chem Chem Phys. 2015;17:25845-53 pubmed publisher
    ..The C1s, N1s, and O1s photoelectron spectra (XPS) were theoretically simulated by calculating the vertical Ionization ..
  45. Turedi S, Tatli O, Alver A, Karaguzel E, Karaca Y, Turkmen S, et al. The Diagnostic Value of Plasma SCUBE1, a Novel Biomarker of Platelet Activation, in Testicular Torsion: A Randomized, Controlled, Experimental Study. Urology. 2015;86:516-20 pubmed publisher
    To investigate the potential diagnostic value of plasma signal peptide, CUB (complement proteins C1r/C1s, Uegf, Bmp1) domain, epidermal growth factor (EGF)-like 1 (SCUBE1) protein in experimentally induced testicular torsion (TT)...
  46. Wijeyewickrema L, Lameignere E, Hor L, Duncan R, Shiba T, Travers R, et al. Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor. Blood. 2016;128:1766-76 pubmed publisher
    ..The serpin, C1-esterase inhibitor (C1-INH), is the only known plasma inhibitor of C1s, the initiating serine protease of the classical pathway of complement...
  47. Keizer M, Pouw R, Kamp A, Patiwael S, Marsman G, Hart M, et al. TFPI inhibits lectin pathway of complement activation by direct interaction with MASP-2. Eur J Immunol. 2015;45:544-50 pubmed publisher
    ..identify TFPI as a novel selective inhibitor of MASP-2, without affecting MASP-1 or the classical pathway proteases C1s and C1r. Kunitz-2 domain of TFPI is required for the inhibition of MASP-2...
  48. McDonald C, Ostini L, Bennett N, Subramaniam N, Hooper J, Velasco G, et al. Functional analysis of matriptase-2 mutations and domains: insights into the molecular basis of iron-refractory iron deficiency anemia. Am J Physiol Cell Physiol. 2015;308:C539-47 pubmed publisher
    ..domains from MT-2 with those from MT-1 resulted in limited cell surface localization, while the complement C1r/C1s, Uegf, Bmp1 (CUB) domain chimera retained localization at the cell surface...
  49. Chen G, Fang X, Yu M. Regulation of gene expression in rats with spinal cord injury based on microarray data. Mol Med Rep. 2015;12:2465-72 pubmed publisher
    ..g. HMGCS1, FDFT1 and IDI1) were negatively correlated with time, while injury genes (e.g. SERPING1, C1S and RAB27A) were positively correlated with time after SCI...
  50. Wallis R, Mitchell D, Schmid R, Schwaeble W, Keeble A. Paths reunited: Initiation of the classical and lectin pathways of complement activation. Immunobiology. 2010;215:1-11 pubmed publisher
    ..knowledge is still incomplete, especially with regard to the interactions between its subcomponents C1q, C1r and C1s that trigger activation upon binding to a microbial target...
  51. Chen J, Schmucker L, Visco D. Pharmaceutical Machine Learning: Virtual High-Throughput Screens Identifying Promising and Economical Small Molecule Inhibitors of Complement Factor C1s. Biomolecules. 2018;8: pubmed publisher
    ..Additional structure⁻property analysis was performed on the active and inactive compounds to identify interesting scaffolds for further investigation. ..
  52. Godahewa G, Bathige S, Herath H, Noh J, Lee J. Characterization of rock bream (Oplegnathus fasciatus) complement components C1r and C1s in terms of molecular aspects, genomic modulation, and immune responsive transcriptional profiles following bacterial and viral pathogen exposure. Fish Shellfish Immunol. 2015;46:656-68 pubmed publisher
    The complement components C1r and C1s play a crucial role in innate immunity via activation of the classical complement cascade system. As initiators of the pathogen-induced signaling cascade, C1r and C1s modulate innate immunity...
  53. Bisschops L, Van Der Hoeven J, Mollnes T, Hoedemaekers C. Seventy-two hours of mild hypothermia after cardiac arrest is associated with a lowered inflammatory response during rewarming in a prospective observational study. Crit Care. 2014;18:546 pubmed publisher
    ..and monocyte chemotactic protein 1), intercellular adhesion molecule 1 and complement activation products (C1r-C1s-C1inhibitor, C4bc, C3bPBb, C3bc and terminal complement complex) were measured...
  54. Leroy C, Shen Q, Strande V, Meyer R, McLaughlin M, Lezan E, et al. CUB-domain-containing protein 1 overexpression in solid cancers promotes cancer cell growth by activating Src family kinases. Oncogene. 2015;34:5593-8 pubmed publisher
    The transmembrane glycoprotein, CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein 1 (CDCP1) is overexpressed in several cancer types and is a predictor of poor prognosis for patients on standard of care therapies...
  55. Wang Z, Wang Z, Zhou Z, Ren Y. Crucial genes associated with diabetic nephropathy explored by microarray analysis. BMC Nephrol. 2016;17:128 pubmed publisher
    ..g. ACTN4, CTNNA1 and ITGB5), as well as complement and coagulation cascades (e.g. C1R and C1S). Furthermore, a series of miRNAs and TFs modulating DEGs were identified...
  56. Tang M, Pelkey K, Ng D, Ivakine E, McBain C, Salter M, et al. Neto1 is an auxiliary subunit of native synaptic kainate receptors. J Neurosci. 2011;31:10009-18 pubmed publisher
    ..We previously identified the CUB (complement C1r/C1s, Uegf, Bmpl) domain protein, Neto1, as an NMDA receptor-associated polypeptide...
  57. Truedsson L. Classical pathway deficiencies - A short analytical review. Mol Immunol. 2015;68:14-9 pubmed publisher
    ..Deficiencies of each of the components (C1q, C1s, C1r, C4 and C2) imply increased susceptibility to bacterial infections...
  58. Batu E, Kosukcu C, Taşkıran E, Sahin S, Akman S, Sozeri B, et al. Whole Exome Sequencing in Early-onset Systemic Lupus Erythematosus. J Rheumatol. 2018;: pubmed publisher
    ..100G>A/p.Gly34Arg) in C1QC in 1; homozygous missense alteration (c.1945G>C/ p.Ala649Pro) in C1S in 1 (novel variant); and homozygous frameshift alteration (c.289_290delAC/ p...
  59. Huang S, Shin K, Sarker M, Rainey J. Apela exhibits isoform- and headgroup-dependent modulation of micelle binding, peptide conformation and dynamics. Biochim Biophys Acta Biomembr. 2017;1859:767-778 pubmed publisher
    ..the first biophysical characterization of three apela isoforms, apela-54, -32, and -11, alongside a monomeric C1S-apela-11 mutant, using circular dichroism (CD) spectropolarimetry and nuclear magnetic resonance (NMR) spectroscopy...
  60. Venkatraman Girija U, Furze C, Toth J, Schwaeble W, Mitchell D, Keeble A, et al. Engineering novel complement activity into a pulmonary surfactant protein. J Biol Chem. 2010;285:10546-52 pubmed publisher
    ..serine proteases: MBLs and ficolins with MBL-associated serine protease-2 (MASP-2) and C1q with C1r and C1s. To examine the structural requirements for complement activation, we have created a number of novel recombinant ..
  61. Wright H, Arulmoli J, Motazedi M, Nelson L, Heinemann F, Flanagan L, et al. CDCP1 cleavage is necessary for homodimerization-induced migration of triple-negative breast cancer. Oncogene. 2016;35:4762-72 pubmed publisher
    ..TNBCs express high levels of the transmembrane glycoprotein, complement C1r/C1s, Uegf, Bmp1 (CUB)-domain containing protein 1 (CDCP1), which has been correlated with the aggressiveness and poor ..
  62. Shum A, Fung D, Corley S, McGill M, Bentley N, Tan T, et al. Cardiac and skeletal muscles show molecularly distinct responses to cancer cachexia. Physiol Genomics. 2015;47:588-99 pubmed publisher
    ..inflammatory genes in the cardiac and skeletal muscle of independent cachectic samples; this revealed that B4galt1, C1s, Serpina3n, and Vsig4 were significantly upregulated in cardiac tissue, whereas C1s and Serpina3n were ..
  63. Colonna L, Parry G, Panicker S, Elkon K. Uncoupling complement C1s activation from C1q binding in apoptotic cell phagocytosis and immunosuppressive capacity. Clin Immunol. 2016;163:84-90 pubmed publisher
    ..Using human in vitro systems and the novel antibody complement C1s inhibitor TNT003, we uncoupled the role of the enzymatic activation of the classical pathway from the opsonizing ..
  64. Xavier S, Sahu R, Landes S, Yu J, Taylor R, Ayyadevara S, et al. Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis. Am J Physiol Renal Physiol. 2017;312:F516-F532 pubmed publisher
    ..and flow cytometry analysis performed in whole kidney tissue confirmed increased expression of C1q, C1r, and C1s as well as complement activation, which is measured as increased synthesis of C3 fragments predominantly in the ..
  65. Gebodh N, Vanegas M, Kelly S. Effects of Stimulus Size and Contrast on the Initial Primary Visual Cortical Response in Humans. Brain Topogr. 2017;30:450-460 pubmed publisher
    ..position that activates the left lower calcarine bank in each individual, and afterwards measured robust negative C1s over posterior midline scalp to gratings presented sequentially at that location...
  66. Gautam A, Panse Y, Ghosh P, Reza M, Mullick J, Sahu A. Mutational analysis of Kaposica reveals that bridging of MG2 and CUB domains of target protein is crucial for the cofactor activity of RCA proteins. Proc Natl Acad Sci U S A. 2015;112:12794-9 pubmed publisher
    ..Furthermore, the model suggested that the C3b-interacting residues bridge the CUB (complement C1r-C1s, Uegf, Bmp1) and MG2 (macroglobulin-2) domains of C3b...
  67. Goshima M, Sekiguchi R, Matsushita M, Nonaka M. The complement system of elasmobranches revealed by liver transcriptome analysis of a hammerhead shark, Sphyrna zygaena. Dev Comp Immunol. 2016;61:13-24 pubmed publisher
    ..Identified genes were; one C1qB, one C1r, one C1s, one MASP-1/-3, one MASP-2, two factor B/C2, one C3, three C4, one C5, one C6, one C7, one C8A, three C8B, one C8G, ..
  68. Emmens R, Wouters D, Zeerleder S, Van Ham S, Niessen H, Krijnen P. On the value of therapeutic interventions targeting the complement system in acute myocardial infarction. Transl Res. 2017;182:103-122 pubmed publisher
    ..have been described for cobra venom factor, soluble complement receptor 1, C1-esterase inhibitor (C1-inh), FUT-175, C1s-inhibitor, anti-C5, ADC-1004, clusterin, and glycosaminoglycans...
  69. Gong V, França R. Nanoscale chemical surface characterization of four different types of dental pulp-capping materials. J Dent. 2017;58:11-18 pubmed publisher
    ..were obtained, with element-dependent probe depths of 4-5nm; the binding energy scale was normalized to the C1s adventitious carbon peak at 285eV...
  70. Bally I, Ancelet S, Moriscot C, Gonnet F, Mantovani A, Daniel R, et al. Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites. Proc Natl Acad Sci U S A. 2013;110:8650-5 pubmed publisher
    ..components, and triggers the classical complement pathway through activation of its associated proteases C1r and C1s. We report a method for expression of recombinant full-length human C1q involving stable transfection of HEK 293-F ..
  71. Almitairi J, Venkatraman Girija U, Furze C, Simpson Gray X, Badakshi F, Marshall J, et al. Structure of the C1r-C1s interaction of the C1 complex of complement activation. Proc Natl Acad Sci U S A. 2018;115:768-773 pubmed publisher
    ..It is formed from the recognition subcomponent C1q and a tetramer of proteases C1r2C1s2 as a Ca2+-dependent complex...
  72. Yan W, Che L, Jiang J, Yang F, Duan Q, Song H, et al. Depletion of complement system immunity in patients with myocardial infarction. Mol Med Rep. 2016;14:5350-5356 pubmed publisher
    ..05), whereas the mRNA levels of C1s, C7, C8? and C9 were the lowest in this group (P<0.05)...
  73. Gladys M, Han J, Pedersen T, Tadich A, O Donnell K, Thomsen L. Adsorption differences between low coverage enantiomers of alanine on the chiral Cu{421}R surface. Phys Chem Chem Phys. 2017;19:13562-13570 pubmed publisher
    ..At approximately one third of a monolayer a comparison of the C1s XPS signal showed a shift in the methyl group of more than 300 meV indicating that the two enantiomers are in ..
  74. Uchio Yamada K, Tanaka M, Manabe N. C1r/C1s deficiency is insufficient to induce murine systemic lupus erythematosus. Genes Immun. 2019;20:121-130 pubmed publisher
    b>C1s deficiency is strongly associated with the development of human systemic lupus erythematosus (SLE); however, the mechanisms by which C1s deficiency contributes to the development of SLE have not yet been elucidated in detail...
  75. Lee H, Choi D, Shin M, Kim J, Kim I, Hong J. Anatomical feasibility for safe occipital condyle screw fixation. Eur Spine J. 2016;25:1674-82 pubmed publisher
    ..The vertebral artery diameter and two kinds of bony space were measured. The occipito-C1 arch space (O-C1S) and VA-occipital bone distance (VOD, six entry points) were measured on both sides...
  76. Acocella A, de Simone M, Evangelista F, Coreno M, Rudolf P, Zerbetto F. Time-dependent quantum simulation of coronene photoemission spectra. Phys Chem Chem Phys. 2016;18:13604-15 pubmed publisher
    ..The theoretical analysis of valence band and C1s core level photoemission spectra showed that multiple excitations play an important role in determining the ..
  77. Nilojan J, Bathige S, Thulasitha W, Kwon H, Jung S, Kim M, et al. Transcriptional profiling, molecular cloning, and functional analysis of C1 inhibitor, the main regulator of the complement system in black rockfish, Sebastes schlegelii. Fish Shellfish Immunol. 2018;75:263-273 pubmed publisher
    ..For the first time, the anti-protease activity of the teleost C1inh against its natural substrates C1r and C1s was proved in this study...
  78. Soliman A, Ichii T, Utsunomiya T, Sugimura H. Chemical conversion of self-assembled hexadecyl monolayers with active oxygen species generated by vacuum ultraviolet irradiation in an atmospheric environment. Soft Matter. 2015;11:5678-87 pubmed publisher
    ..The difference between the oxygenated carbon components derived by the deconvolution of the XPS carbon (C1s) spectrum and the chemical labeling of polar groups revealed enormous quantities of ethereal and ester groups that ..
  79. Sorrenti G, Masiello C, Dugan B, Toselli M. Biochar physico-chemical properties as affected by environmental exposure. Sci Total Environ. 2016;563-564:237-46 pubmed publisher
    ..Finally, we investigated the chemical properties, surface, inner layers atomic composition and C1s bonding state of biochar fragments through X-ray photoelectron spectroscopy (XPS)...
  80. Kennedy A, Wijeyewickrema L, Huglo A, Lin C, Pike R, Cowman A, et al. Recruitment of Human C1 Esterase Inhibitor Controls Complement Activation on Blood Stage Plasmodium falciparum Merozoites. J Immunol. 2017;198:4728-4737 pubmed publisher
    ..b>C1 esterase inhibitor (C1-INH) is a soluble regulator of complement activation that negatively regulates the classical and ..
  81. Sun P, Hui C, Wang S, Wan L, Zhang X, Zhao Y. Bacillus amyloliquefaciens biofilm as a novel biosorbent for the removal of crystal violet from solution. Colloids Surf B Biointerfaces. 2016;139:164-70 pubmed publisher
    ..The relative contents of three main elements (C1s, O1s, and N1s) in the biofilm were 65.55%, 21.21%, and 13.24%, respectively...
  82. Mohapatra S, Samantaray D, Samantaray S, Mishra B, Das S, Majumdar S, et al. Structural and thermal characterization of PHAs produced by Lysinibacillus sp. through submerged fermentation process. Int J Biol Macromol. 2016;93:1161-1167 pubmed publisher
    ..The C/O of biopolymer disc was 1:65 as revealed from C1s and O1s spectra of XPS, that was completely biodegradable within 30 days...
  83. Thiemmeca S, Tamdet C, Punyadee N, Prommool T, Songjaeng A, Noisakran S, et al. Secreted NS1 Protects Dengue Virus from Mannose-Binding Lectin-Mediated Neutralization. J Immunol. 2016;197:4053-4065 pubmed
    ..Both mammalian and insect cell-derived NS1 bind to complement proteins C1s, C4, and C4-binding protein, as well as to a novel partner, mannose-binding lectin...
  84. Kobayashi H, Albarracín L, Sato N, Kanmani P, Kober A, Ikeda Ohtsubo W, et al. Modulation of porcine intestinal epitheliocytes immunetranscriptome response by Lactobacillus jensenii TL2937. Benef Microbes. 2016;7:769-782 pubmed
    ..The decrease in the expression of chemokines (CCL8, CXCL5, CXCL9, CXCL10, and CXCL11), complement (C1R, C1S, C3, and CFB), and coagulation factors (F3) by L...
  85. Tewari S, Renney G, Brewin J, Gardner K, Kirkham F, Inusa B, et al. Proteomic analysis of plasma from children with sickle cell anemia and silent cerebral infarction. Haematologica. 2018;103:1136-1142 pubmed publisher
    ..2-antiplasmin, fibrinogen-γ chain, thrombospondin-4), inflammation (α2-macroglobulin, complement C1s and C3), and atherosclerosis (apolipoprotein B-100)...
  86. Lacroix M, Tessier A, Dumestre Pérard C, Vadon Le Goff S, Gout E, Bruckner Tuderman L, et al. Interaction of Complement Defence Collagens C1q and Mannose-Binding Lectin with BMP-1/Tolloid-like Proteinases. Sci Rep. 2017;7:16958 pubmed publisher
    ..C1q and mannose-binding lectin (MBL) are immune recognition proteins that associate with the serine proteinases C1r/C1s and MBL-associated serine proteases (MASPs) to trigger activation of complement, a major innate immune system...
  87. Illy C, Thielens N, Gagnon J, Arlaud G. Effect of lactoperoxidase-catalyzed iodination on the Ca(2+)-dependent interactions of human C1s. Location of the iodination sites. Biochemistry. 1991;30:7135-41 pubmed
    ..On the basis of available information, tentative models of the C-1s-C-1s and C-1r-C-1s Ca(2+)-dependent interactions are proposed. ..
  88. Kauffman D, Hofmann T, Bennick A, Keller P. Basic proline-rich proteins from human parotid saliva: complete covalent structures of proteins IB-1 and IB-6. Biochemistry. 1986;25:2387-92 pubmed
    ..The relationship of these proteins to the basic proline-rich protein IB-9 [Kauffman, D., Wong, R., Bennick, A., & Keller, P. (1982) Biochemistry 21, 6558-6562] and to other salivary proline-rich proteins is discussed. ..
  89. Amano M, Ferriani V, Florido M, Reis E, Delcolli M, Azzolini A, et al. Genetic analysis of complement C1s deficiency associated with systemic lupus erythematosus highlights alternative splicing of normal C1s gene. Mol Immunol. 2008;45:1693-702 pubmed
    ..Deficiency of C1r has been observed to occur concomitantly with deficiency in C1s and 9 out of 15 reported cases presented systemic lupus erythematosus (SLE)...
  90. Mirabelli P, Mukwaya A, Lennikov A, Xeroudaki M, Peebo B, Schaupper M, et al. Genome-wide expression differences in anti-Vegf and dexamethasone treatment of inflammatory angiogenesis in the rat cornea. Sci Rep. 2017;7:7616 pubmed publisher
    ..of Reg3g and the inflammatory chemokines Ccl2 and Cxcl5 and activation of classical complement pathway factors C1r, C1s, C2, and C3 occurred with dexamethasone treatment, effects absent with anti-Vegf treatment...
  91. Pelevkin A, Loukhovitski B, Sharipov A. Reaction of H2 with O2 in Excited Electronic States: Reaction Pathways and Rate Constants. J Phys Chem A. 2017;: pubmed publisher
    ..active space self-consistent field approach was carried out to study the reactions of H2 with O2 in a1Dg, b1S+ g , c1S- u , and A'3Du electronically excited states...
  92. Gaboriaud C, Rossi V, Bally I, Arlaud G, Fontecilla Camps J. Crystal structure of the catalytic domain of human complement c1s: a serine protease with a handle. EMBO J. 2000;19:1755-65 pubmed
    b>C1s is the highly specific modular serine protease that mediates the proteolytic activity of the C1 complex and thereby triggers activation of the complement cascade...