C1QBP

Summary

Gene Symbol: C1QBP
Description: complement C1q binding protein
Alias: COXPD33, GC1QBP, HABP1, SF2p32, gC1Q-R, gC1qR, p32, complement component 1 Q subcomponent-binding protein, mitochondrial, ASF/SF2-associated protein p32, C1q globular domain-binding protein, complement component 1, q subcomponent binding protein, glycoprotein gC1qBP, hyaluronan-binding protein 1, mitochondrial matrix protein p32, p33, splicing factor SF2-associated protein
Species: human
Products:     C1QBP

Top Publications

  1. Chattopadhyay C, Hawke D, Kobayashi R, Maity S. Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. Nucleic Acids Res. 2004;32:3632-41 pubmed
    ..Here we show that the p32 protein, previously identified as the ASF/SF2 splicing factor-associated protein, copurified with the CBF complex...
  2. Rozanov D, Ghebrehiwet B, Postnova T, Eichinger A, Deryugina E, Strongin A. The hemopexin-like C-terminal domain of membrane type 1 matrix metalloproteinase regulates proteolysis of a multifunctional protein, gC1qR. J Biol Chem. 2002;277:9318-25 pubmed
    ..Recently, we established a functional link between MT1-MMP and the receptor of complement component 1q (gC1qR). The gC1qR is known as a compartment-specific regulator of diverse cellular and viral proteins...
  3. Krainer A, Mayeda A, Kozak D, Binns G. Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators. Cell. 1991;66:383-94 pubmed
    ..Like transformer-2 and 70K, SF2 contains an RNP-type RNA recognition motif. ..
  4. Fogal V, Zhang L, Krajewski S, Ruoslahti E. Mitochondrial/cell-surface protein p32/gC1qR as a molecular target in tumor cells and tumor stroma. Cancer Res. 2008;68:7210-8 pubmed publisher
    ..Here, we show that the protein known as p32 or gC1q receptor is the receptor for LyP-1...
  5. Yao Z, Eisen Vandervelde A, Waggoner S, Cale E, Hahn Y. Direct binding of hepatitis C virus core to gC1qR on CD4+ and CD8+ T cells leads to impaired activation of Lck and Akt. J Virol. 2004;78:6409-19 pubmed
    ..It has been shown that the binding of C1q, a natural ligand of gC1qR, on T cells inhibits their proliferation...
  6. Joseph K, Ghebrehiwet B, Peerschke E, Reid K, Kaplan A. Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor that binds to the globular "heads" of C1q (gC1q-R). Proc Natl Acad Sci U S A. 1996;93:8552-7 pubmed
    ..Taken together, the data suggest that HK (and factor XII) bind to HUVECs via a 33-kDa cell surface glycoprotein that appears to be identical to gC1q-R but interact with a site on gC1q-R distinct from that which binds C1q. ..
  7. Itahana K, Zhang Y. Mitochondrial p32 is a critical mediator of ARF-induced apoptosis. Cancer Cell. 2008;13:542-53 pubmed publisher
    ..Here, we report that the mitochondrial protein p32/C1QBP binds the ARF C terminus...
  8. Amamoto R, Yagi M, Song Y, Oda Y, Tsuneyoshi M, Naito S, et al. Mitochondrial p32/C1QBP is highly expressed in prostate cancer and is associated with shorter prostate-specific antigen relapse time after radical prostatectomy. Cancer Sci. 2011;102:639-47 pubmed publisher
    ..Therefore, impairment of mitochondria can modulate or accelerate cancer progression. p32, originally identified as a pre-mRNA splicing factor SF2/ASF-associated protein, is localized predominantly in the ..
  9. Ghebrehiwet B, Lim B, Peerschke E, Willis A, Reid K. Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q. J Exp Med. 1994;179:1809-21 pubmed
    ..abstract truncated at 400 words) ..

More Information

Publications93

  1. Agostinis C, Bulla R, Tripodo C, Gismondi A, Stabile H, Bossi F, et al. An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development. J Immunol. 2010;185:4420-9 pubmed publisher
    ..Ab inhibition experiments showed that the receptors for the globular head of C1q/p33 and ?(4)?(1) integrin were both involved in this process and were colocalized on the cell surface following binding ..
  2. Prakash M, Kale S, Ghosh I, Kundu G, Datta K. Hyaluronan-binding protein 1 (HABP1/p32/gC1qR) induces melanoma cell migration and tumor growth by NF-kappa B dependent MMP-2 activation through integrin ?(v)?(3) interaction. Cell Signal. 2011;23:1563-77 pubmed publisher
    ..In the present report, we demonstrated, supplementation of purified recombinant hyaluronan binding protein 1(HABP1/p32/gC1qR) from human fibroblast cDNA enhanced migration potential of highly invasive melanoma (..
  3. Sunayama J, Ando Y, Itoh N, Tomiyama A, Sakurada K, Sugiyama A, et al. Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32. Cell Death Differ. 2004;11:771-81 pubmed
    ..in Hrk-mediated apoptosis, we have conducted yeast two-hybrid screening for Hrk-interacting proteins and isolated p32, a mitochondrial protein that has been shown to form a channel consisting of its homotrimer...
  4. Li Y, Wan O, Xie W, Chung K. p32 regulates mitochondrial morphology and dynamics through parkin. Neuroscience. 2011;199:346-58 pubmed publisher
    ..In this study, we have identified a mitochondrial protein p32 as a novel interactor of parkin in the brain...
  5. Yu H, Liu Q, Xin T, Xing L, Dong G, Jiang Q, et al. Elevated expression of hyaluronic acid binding protein 1 (HABP1)/P32/C1QBP is a novel indicator for lymph node and peritoneal metastasis of epithelial ovarian cancer patients. Tumour Biol. 2013;34:3981-7 pubmed publisher
    The present study aims to clarify whether hyaluronan binding protein 1 (HABP1/p32/C1QBP) is an indicator of peritoneal and lymph node metastasis in epithelial ovarian cancer (EOC), which to the authors' knowledge is not previously ..
  6. Biswas A, Hafiz A, Banerjee B, Kim K, Datta K, Chitnis C. Plasmodium falciparum uses gC1qR/HABP1/p32 as a receptor to bind to vascular endothelium and for platelet-mediated clumping. PLoS Pathog. 2007;3:1271-80 pubmed
    ..falciparum IRBCs use the 32-kDa human protein gC1qR/HABP1/p32 as a receptor to bind to human brain microvascular endothelial cells. In addition, we show that P...
  7. Zhang X, Zhang F, Guo L, Wang Y, Zhang P, Wang R, et al. Interactome analysis reveals that C1QBP (complement component 1, q subcomponent binding protein) is associated with cancer cell chemotaxis and metastasis. Mol Cell Proteomics. 2013;12:3199-209 pubmed publisher
    The complement component 1, q subcomponent binding protein (C1QBP/p32/HABP1) is a ubiquitously expressed and multicompartmental cellular protein involved in various biological processes...
  8. Feng X, Tonnesen M, Peerschke E, Ghebrehiwet B. Cooperation of C1q receptors and integrins in C1q-mediated endothelial cell adhesion and spreading. J Immunol. 2002;168:2441-8 pubmed
    ..In this study we examined the roles of two C1q binding proteins, cC1q-R/calreticulin and gC1q-R/p33, in C1q-mediated adhesion and spreading of human dermal microvascular endothelial cells (HDMVEC)...
  9. Beatch M, Hobman T. Rubella virus capsid associates with host cell protein p32 and localizes to mitochondria. J Virol. 2000;74:5569-76 pubmed
    ..One protein that interacted strongly with capsid was p32, a cellular protein which is known to interact with other viral proteins...
  10. Deb T, Datta K. Molecular cloning of human fibroblast hyaluronic acid-binding protein confirms its identity with P-32, a protein co-purified with splicing factor SF2. Hyaluronic acid-binding protein as P-32 protein, co-purified with splicing factor SF2. J Biol Chem. 1996;271:2206-12 pubmed
    ..quot; ..
  11. Majumdar M, Meenakshi J, Goswami S, Datta K. Hyaluronan binding protein 1 (HABP1)/C1QBP/p32 is an endogenous substrate for MAP kinase and is translocated to the nucleus upon mitogenic stimulation. Biochem Biophys Res Commun. 2002;291:829-37 pubmed
    The role of hyaluronan binding protein 1 (HABP1) in cell signaling was investigated and in vitro kinase assay demonstrated that it is a substrate for MAP kinase...
  12. Kim K, Yi J, Nguyen N, Lee J, Kwon Y, Ahn B, et al. Cell-surface receptor for complement component C1q (gC1qR) is a key regulator for lamellipodia formation and cancer metastasis. J Biol Chem. 2011;286:23093-101 pubmed publisher
    We previously demonstrated that the receptor for the complement component C1q (gC1qR) is a lipid raft protein that is indispensable for adipogenesis and insulin signaling...
  13. Fogal V, Richardson A, Karmali P, Scheffler I, Smith J, Ruoslahti E. Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation. Mol Cell Biol. 2010;30:1303-18 pubmed publisher
    p32/gC1qR/C1QBP/HABP1 is a mitochondrial/cell surface protein overexpressed in certain cancer cells...
  14. Storz P, Hausser A, Link G, Dedio J, Ghebrehiwet B, Pfizenmaier K, et al. Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32. J Biol Chem. 2000;275:24601-7 pubmed
    We identified the multifunctional chaperon protein p32 as a protein kinase C (PKC)-binding protein interacting with PKCalpha, PKCzeta, PKCdelta, and PKC mu...
  15. Xu L, Xiao N, Liu F, Ren H, Gu J. Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria. Proc Natl Acad Sci U S A. 2009;106:1530-5 pubmed publisher
    b>gC1qR is one of the C1q receptors implicated in the regulation of innate and adaptive immunity. We found that gC1qR inhibits RIG-I and MDA5-dependent antiviral signaling...
  16. Kaul R, Saha P, Saradhi M, Prasad R, Chatterjee S, Ghosh I, et al. Overexpression of hyaluronan-binding protein 1 (HABP1/p32/gC1qR) in HepG2 cells leads to increased hyaluronan synthesis and cell proliferation by up-regulation of cyclin D1 in AKT-dependent pathway. J Biol Chem. 2012;287:19750-64 pubmed publisher
    Overexpression of the mature form of hyaluronan-binding protein 1 (HABP1/gC1qR/p32), a ubiquitous multifunctional protein involved in cellular signaling, in normal murine fibroblast cells leads to enhanced generation of reactive oxygen ..
  17. Chen Y, Jiang C, Zhang G, Wang J, Pang D. Increased expression of hyaluronic acid binding protein 1 is correlated with poor prognosis in patients with breast cancer. J Surg Oncol. 2009;100:382-6 pubmed publisher
    Hyaluronic acid binding protein 1 (HABP1), a family of proteins interacting with hyaluronan (HA), had been associated with cell adhesion and tumor invasion...
  18. Braun L, Ghebrehiwet B, Cossart P. gC1q-R/p32, a C1q-binding protein, is a receptor for the InlB invasion protein of Listeria monocytogenes. EMBO J. 2000;19:1458-66 pubmed
    ..After E-cadherin, the receptor for internalin, gC1q-R is the second identified mammalian receptor promoting entry of L. monocytogenes into mammalian cells. ..
  19. McGee A, Douglas D, Liang Y, Hyder S, Baines C. The mitochondrial protein C1qbp promotes cell proliferation, migration and resistance to cell death. Cell Cycle. 2011;10:4119-27 pubmed publisher
    Complement 1q-Binding Protein (C1qbp) is a mitochondrial protein reported to be upregulated in cancer. However, whether C1qbp plays a tumor suppressive or tumorigenic role in the progression of cancer is controversial...
  20. Jiang J, Zhang Y, Krainer A, Xu R. Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein. Proc Natl Acad Sci U S A. 1999;96:3572-7 pubmed
    Human p32 (also known as SF2-associated p32, p32/TAP, and gC1qR) is a conserved eukaryotic protein that localizes predominantly in the mitochondrial matrix...
  21. Kittlesen D, Chianese Bullock K, Yao Z, Braciale T, Hahn Y. Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation. J Clin Invest. 2000;106:1239-49 pubmed
    ..as bait, we screened a human T cell-enriched expression library and identified a gene encoding the gC1q receptor (gC1qR). C1q is a ligand of gC1qR and is involved in the early host defense against infection...
  22. Hu M, Crawford S, Henstridge D, Ng I, Boey E, Xu Y, et al. p32 protein levels are integral to mitochondrial and endoplasmic reticulum morphology, cell metabolism and survival. Biochem J. 2013;453:381-91 pubmed publisher
    p32 [also known as HABP1 (hyaluronan-binding protein 1), gC1qR (receptor for globular head domains complement 1q) or C1qbp (complement 1q-binding protein)] has been shown previously to have both mitochondrial and non-mitochondrial ..
  23. Kurpińska A, Suraj J, Bonar E, Zakrzewska A, Stojak M, Sternak M, et al. Proteomic characterization of early lung response to breast cancer metastasis in mice. Exp Mol Pathol. 2019;107:129-140 pubmed publisher
    ..Anxa5), Rho GDP-dissociation inhibitor 2 (Arhgdib), complement 1 Q subcomponent-binding protein, mitochondrial (C1qbp), 14-3-3 protein zeta/delta (Ywhaz), peroxiredoxin-6 (Prdx6), chitinase-like protein 4 (Chi3l4), reticulocalbin-1 (..
  24. Sunwoo S, Pérez Núñez D, Morozov I, Sánchez E, Gaudreault N, Trujillo J, et al. DNA-Protein Vaccination Strategy Does Not Protect from Challenge with African Swine Fever Virus Armenia 2007 Strain. Vaccines (Basel). 2019;7: pubmed publisher
    ..Pigs were vaccinated three times with a cocktail that included ASFV plasmid DNA (CD2v, p72, p32, +/-p17) and recombinant proteins (p15, p35, p54, +/-p17)...
  25. Miyamae Y, Mochizuki S, Shimoda M, Ohara K, Abe H, Yamashita S, et al. ADAM28 is expressed by epithelial cells in human normal tissues and protects from C1q-induced cell death. FEBS J. 2016;283:1574-94 pubmed publisher
    ..C1q-induced cell death was attenuated by treatment of the cells with antibodies against the C1q receptor gC1qR/p33 or cC1qR/calreticulin...
  26. Ansseau E, Eidahl J, Lancelot C, Tassin A, Mattéotti C, Yip C, et al. Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation. PLoS ONE. 2016;11:e0146893 pubmed publisher
    ..and in situ Proximal Ligation Assay) as DUX4/4c partners several RNA-binding proteins such as C1QBP, SRSF9, RBM3, FUS/TLS and SFPQ that are involved in mRNA splicing and translation...
  27. Ghebrehiwet B, Tantral L, Titmus M, Panessa Warren B, Tortora G, Wong S, et al. The exosporium of B. cereus contains a binding site for gC1qR/p33: implication in spore attachment and/or entry. Adv Exp Med Biol. 2007;598:181-97 pubmed
    ..anthracis. Preliminary experiments have shown that gC1qR binds to B. cereus spores that have been attached to microtiter plates...
  28. Westman J, Hansen F, Olin A, Morgelin M, Schmidtchen A, Herwald H. p33 (gC1q receptor) prevents cell damage by blocking the cytolytic activity of antimicrobial peptides. J Immunol. 2013;191:5714-21 pubmed publisher
    ..In this study, we describe that p33, a negatively charged surface protein found on endothelial cells also known as gC1q receptor, protects host cells ..
  29. Scheets K. Analysis of gene functions in Maize chlorotic mottle virus. Virus Res. 2016;222:71-79 pubmed publisher
    ..Transcripts lacking p32 expression accumulate to about 1/3 the level of wild type transcripts in protoplasts and produce delayed, mild ..
  30. Sánchez Martín D, Cuesta A, Fogal V, Ruoslahti E, Alvarez Vallina L. The multicompartmental p32/gClqR as a new target for antibody-based tumor targeting strategies. J Biol Chem. 2011;286:5197-203 pubmed publisher
    ..It has been previously reported that a mitochondrial/cell surface protein, p32/gC1qR, is the receptor for a tumor-homing peptide, LyP-1, which specifically recognizes an epitope in tumor cells, tumor ..
  31. Lv K, Gao L, Hua X, Li F, Gu Y, Wang W. The role of the globular heads of the C1q receptor in paclitaxel-induced human ovarian cancer cells apoptosis by a mitochondria-dependent pathway. Anticancer Drugs. 2017;: pubmed publisher
    As a mitochondrial membrane protein, globular C1q receptor (gC1qR) can mediate a variety of biological responses...
  32. Shi H, Fang W, Liu M, Fu D. Complement component 1, q subcomponent binding protein (C1QBP) in lipid rafts mediates hepatic metastasis of pancreatic cancer by regulating IGF-1/IGF-1R signaling. Int J Cancer. 2017;141:1389-1401 pubmed publisher
    ..Complement component 1, q subcomponent binding protein (C1QBP) can mediate growth factor-induced cancer cell chemotaxis and distant metastasis by activation of receptor ..
  33. Wang Y, Yang Y, Wu S, Pan S, Zhou C, Ma Y, et al. p32 is a novel target for viral protein ICP34.5 of herpes simplex virus type 1 and facilitates viral nuclear egress. J Biol Chem. 2014;289:35795-805 pubmed publisher
    ..5, which is a virulence factor of HSV-1, we identified a cellular protein, p32 (gC1qR/HABP1), by mass spectrophotometer analysis. When expressed, ICP34.5 associated with p32 in mammalian cells...
  34. Breguez G, Neves L, Silva K, de Freitas L, de Oliveira Faria G, Isoldi M, et al. Exposure of cultured fibroblasts to the peptide PR-11 for the identification of induced proteome alterations and discovery of novel potential ligands. Biochim Biophys Acta. 2016;1864:1775-1786 pubmed publisher
    ..Among the eluted molecules, gC1qR, a known complement receptor, appeared markedly enriched...
  35. Wu S, Pan S, Zhang L, Baines J, Roller R, Ames J, et al. Herpes Simplex Virus 1 Induces Phosphorylation and Reorganization of Lamin A/C through the γ134.5 Protein That Facilitates Nuclear Egress. J Virol. 2016;90:10414-10422 pubmed publisher
    ..product of HSV-1 facilitates nucleocapsid release to the cytoplasm through bridging the UL31/UL34 complex, cellular p32, and protein kinase C. Unlike wild-type virus, an HSV mutant devoid of γ134...
  36. Hosszu K, Valentino A, Vinayagasundaram U, Vinayagasundaram R, Joyce M, Ji Y, et al. DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells. Blood. 2012;120:1228-36 pubmed publisher
    ..Because the 2 C1q receptors found on the DC surface-gC1qR and cC1qR-lack a direct conduit into intracellular elements, we postulated that the receptors must form complexes ..
  37. Yanagida M, Hayano T, Yamauchi Y, Shinkawa T, Natsume T, Isobe T, et al. Human fibrillarin forms a sub-complex with splicing factor 2-associated p32, protein arginine methyltransferases, and tubulins alpha 3 and beta 1 that is independent of its association with preribosomal ribonucleoprotein complexes. J Biol Chem. 2004;279:1607-14 pubmed
    ..arginine-rich domain (residues 1-77) and its spacer region 1 (78-132) interact with splicing factor 2-associated p32 (SF2A-p32) and that the FIB methyltransferase-like domain (133-321) interacts with protein-arginine ..
  38. Luo Y, Yu H, Peterlin B. Cellular protein modulates effects of human immunodeficiency virus type 1 Rev. J Virol. 1994;68:3850-6 pubmed
    ..YL2 has 92% identity to a human 32-kDa protein (p32), which copurifies with alternative splicing factor SF2/ASF...
  39. Johnson G, Buck T, Sullivan D, Rohde G, Murphy R. Joint modeling of cell and nuclear shape variation. Mol Biol Cell. 2015;26:4046-56 pubmed publisher
    ..determine the effects of endogenous protein tags or drugs on the shape dynamics of cell lines and show that tagged C1QBP reduces the correlation between cell and nuclear shape...
  40. Paasonen L, Sharma S, Braun G, Kotamraju V, Chung T, She Z, et al. New p32/gC1qR Ligands for Targeted Tumor Drug Delivery. Chembiochem. 2016;17:570-5 pubmed publisher
    Cell surface p32, the target of LyP-1 homing peptide, is upregulated in tumors and atherosclerotic plaques and has been widely used as a receptor for systemic delivery of payloads...
  41. Szostakowska M, Szymczyk M, Badowska K, Tudek B, Fabisiewicz A. SOX11 expression as a MRD molecular marker for MCL in comparison with t(11;14) and IGH rearrangement. Med Oncol. 2018;35:49 pubmed publisher
    ..The most commonly used molecular markers for measuring MRD in MCL are: t(11;14)(q13;p32) translocation or CCND1 expression and IGH rearrangement...
  42. Gao H, Yao Q, Lan X, Li S, Wu J, Zeng G, et al. Elevated HABP1 protein expression correlates with progression and poor survival in patients with gastric cancer. Onco Targets Ther. 2016;9:6711-6718 pubmed
    Hyaluronic acid-binding protein 1 (HABP1/gC1qR/p32) has been recently implicated in oncogenesis and cancer progression in various malignancies; however, its clinical role in gastric cancer (GC) is still unclear...
  43. Liu Y, Leslie P, Jin A, Itahana K, Graves L, Zhang Y. p32 heterozygosity protects against age- and diet-induced obesity by increasing energy expenditure. Sci Rep. 2017;7:5754 pubmed publisher
    ..Here, we identify mitochondrial p32 (also known as C1QBP) as an important regulator of lipid homeostasis that regulates both aerobic and anaerobic energy metabolism...
  44. Majumdar M, Datta K. Assignment of cDNA encoding hyaluronic acid-binding protein 1 to human chromosome 17p12-p13. Genomics. 1998;51:476-7 pubmed
  45. Chung H, Korm S, Lee S, Phorl S, Noh S, Han M, et al. RAP80 binds p32 to preserve the functional integrity of mitochondria. Biochem Biophys Res Commun. 2017;492:441-446 pubmed publisher
    ..Here, we found mitochondrial p32 as a novel binding partner of RAP80 by using yeast two-hybrid screening...
  46. Heyd F, Carmo Fonseca M, Moroy T. Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26. J Biol Chem. 2008;283:19636-45 pubmed publisher
    ..In addition, we could identify P32 as a protein that is able to interact with U2AF26 through this domain, and we demonstrate that this interaction is ..
  47. Feichtinger R, Oláhová M, Kishita Y, Garone C, Kremer L, Yagi M, et al. Biallelic C1QBP Mutations Cause Severe Neonatal-, Childhood-, or Later-Onset Cardiomyopathy Associated with Combined Respiratory-Chain Deficiencies. Am J Hum Genet. 2017;101:525-538 pubmed publisher
    Complement component 1 Q subcomponent-binding protein (C1QBP; also known as p32) is a multi-compartmental protein whose precise function remains unknown...
  48. Schaerer M, Kannenberg K, Hunziker P, Baumann S, Sigel E. Interaction between GABA(A) receptor beta subunits and the multifunctional protein gC1q-R. J Biol Chem. 2001;276:26597-604 pubmed
    ..Our observations therefore suggest a tight interaction between gC1q-R and the GABA(A) receptor which might be involved in receptor biosynthesis or modulation of the mature function. ..
  49. Burstein S, Valsecchi F, Kawamata H, Bourens M, Zeng R, Zuberi A, et al. In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions. Hum Mol Genet. 2018;27:160-177 pubmed publisher
    ..Furthermore, both CHCHD10 and CHCHD2 interact with p32/GC1QR, a protein with various intra and extra-mitochondrial functions...
  50. Wang Y, Fu D, Su J, Chen Y, Qi C, Sun Y, et al. C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells. Sci Rep. 2017;7:999 pubmed publisher
    Complement component 1q subcomponent binding protein (C1QBP) is a ubiquitously expressed cellular protein and can be upregulated or activated in a variety of malignant tumors, including those from thyroid, colon and breast, but its role ..
  51. Huang L, Chi J, Berry F, Footz T, Sharp M, Walter M. Human p32 is a novel FOXC1-interacting protein that regulates FOXC1 transcriptional activity in ocular cells. Invest Ophthalmol Vis Sci. 2008;49:5243-9 pubmed publisher
    ..The human p32 protein was isolated as a putative FOXC1-interacting protein from a Y2H screen...
  52. Anders E, Nebel D, Westman J, Herwald H, Nilsson B, Svensson D. Globular C1q receptor (p33) binds and stabilizes pro-inflammatory MCP-1: a novel mechanism for regulation of MCP-1 production and function. Biochem J. 2018;475:775-786 pubmed publisher
    The protein gC1qR (globular C1q receptor), also named p33, was originally identified as a binding partner of the globular heads of C1q in the complement system...
  53. Liu Z, Kato A, Oyama M, Kozuka Hata H, Arii J, Kawaguchi Y. Role of Host Cell p32 in Herpes Simplex Virus 1 De-Envelopment during Viral Nuclear Egress. J Virol. 2015;89:8982-98 pubmed
    ..mass spectrometry-based proteomics technology and subsequent analyses showed that UL47 interacted with cell protein p32 in HSV-1-infected cells...
  54. Jiao H, Su G, Dong W, Zhang L, Xie W, Yao L, et al. Chaperone-like protein p32 regulates ULK1 stability and autophagy. Cell Death Differ. 2015;22:1812-23 pubmed publisher
    ..b>p32, a chaperone-like protein, is crucial for maintaining mitochondrial membrane potential and oxidative ..
  55. Kobayashi M, Hanai R. M phase-specific association of human topoisomerase IIIbeta with chromosomes. Biochem Biophys Res Commun. 2001;287:282-7 pubmed
    ..The GFP fusion of the isoform 2 was found in the cytoplasm, indicating the nuclear localization signal sequence in the isoform 1 is in the C-terminal part that is different between the two isoforms. ..
  56. Chatel Chaix L, Germain M, Motorina A, Bonneil E, Thibault P, Baril M, et al. A host YB-1 ribonucleoprotein complex is hijacked by hepatitis C virus for the control of NS3-dependent particle production. J Virol. 2013;87:11704-20 pubmed publisher
    ..Following extensive interaction and functional validation, we identified three YB-1 partners, C1QBP, LARP-1, and IGF2BP2, that redistribute to the surface of core-containing lipid droplets in HCV JFH-1-expressing ..
  57. Xiao K, Wang Y, Chang Z, Lao Y, Chang D. p32, a novel binding partner of Mcl-1, positively regulates mitochondrial Ca(2+) uptake and apoptosis. Biochem Biophys Res Commun. 2014;451:322-8 pubmed publisher
    ..Based on Yeast Two-Hybrid screening and co-immunoprecipitation, we identified a mitochondrial protein p32 (C1qbp) as a novel binding partner of Mcl-1...
  58. Fridell R, Harding L, Bogerd H, Cullen B. Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins. Virology. 1995;209:347-57 pubmed publisher
    ..Overall, these data suggest that HT2A may play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo...
  59. Wang Y, Yue D, Xiao M, Qi C, Chen Y, Sun D, et al. C1QBP negatively regulates the activation of oncoprotein YBX1 in the renal cell carcinoma as revealed by interactomics analysis. J Proteome Res. 2015;14:804-13 pubmed publisher
    ..The interaction between the complement component 1, q subcomponent binding protein (C1QBP), and YBX1 was further confirmed by immunoprecipitation and Western blotting...
  60. Moorman J, Fitzgerald S, Prayther D, Lee S, Chi D, Krishnaswamy G. Induction of p38- and gC1qR-dependent IL-8 expression in pulmonary fibroblasts by soluble hepatitis C core protein. Respir Res. 2005;6:105 pubmed
    ..HCV core-mediated expression of IL-8 was inhibited by blocking gC1qR, a known receptor for soluble HCV core linked to MAPK signaling...
  61. Suppiah S, Mousa H, Tzeng W, Matthews J, Frey T. Binding of cellular p32 protein to the rubella virus P150 replicase protein via PxxPxR motifs. J Gen Virol. 2012;93:807-16 pubmed publisher
    ..using a glutathione S-transferase-PRR fusion revealed PxxPxR motif-specific binding with human p32 protein (gC1qR), which could be mediated by either of the first two motifs...
  62. Teo P, Wang X, Zhang J, Zhang H, Yang X, Huang Y, et al. LyP-1-conjugated Fe3O4 nanoparticles suppress tumor growth by magnetic induction hyperthermia. J Biomater Sci Polym Ed. 2017;:1-28 pubmed publisher
    ..LyP-1-SPIONs are promising in treating cancer as they accumulated in the nucleus of MCF-7 cells which expressed p32 and almost stopped tumor growth by combined MIH and targeted therapy.
  63. Mallick J, Datta K. HABP1/p32/gC1qR induces aberrant growth and morphology in Schizosaccharomyces pombe through its N-terminal alpha helix. Exp Cell Res. 2005;309:250-63 pubmed
    Hyaluronan binding protein (HABP1), located on human chromosome 17p13.3, was identified and characterized as being involved in cellular signaling from our laboratory...
  64. Yadav G, Prasad R, Jha B, Rai V, Bhakuni V, Datta K. Evidence for inhibitory interaction of hyaluronan-binding protein 1 (HABP1/p32/gC1qR) with Streptococcus pneumoniae hyaluronidase. J Biol Chem. 2009;284:3897-905 pubmed publisher
    ..protecting it from degradation, here we investigated inhibitory activity of human hyaluronan-binding protein 1 (HABP1) on bacterial hyaluronidase because it is highly specific to HA and localized on the cell surface...
  65. Yogarajah M, Tefferi A. Leukemic Transformation in Myeloproliferative Neoplasms: A Literature Review on Risk, Characteristics, and Outcome. Mayo Clin Proc. 2017;92:1118-1128 pubmed publisher
    ..abnormal karyotype, mutations involving SRSF2 and IDH2, and treatment with pipobroman, chlorambucil, or P32; and for PMF, increased blast percentage, thrombocytopenia, abnormal karyotype, triple-negative driver mutational ..
  66. Mayor A, Hafiz A, Bassat Q, Rovira Vallbona E, Sanz S, Machevo S, et al. Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor. PLoS ONE. 2011;6:e19422 pubmed publisher
    ..properties such as platelet-mediated clumping, rosetting and adhesion to purified receptors (CD36, ICAM1 and gC1qR), were compared between these matched pairs by non-parametric tests...
  67. Hu M, Li H, Bogoyevitch M, Jans D. Mitochondrial protein p32/HAPB1/gC1qR/C1qbp is required for efficient respiratory syncytial virus production. Biochem Biophys Res Commun. 2017;489:460-465 pubmed publisher
    ..Here we examine the role in infection of the host mitochondrial protein p32 (HABP/gC1qR/C1qbp) for the first time...
  68. Cho H, Oh Y, Han S, Chung H, Kim C, Lee N, et al. Cdk1 protein-mediated phosphorylation of receptor-associated protein 80 (RAP80) serine 677 modulates DNA damage-induced G2/M checkpoint and cell survival. J Biol Chem. 2013;288:3768-76 pubmed publisher
    ..These results suggest that post-translational phosphorylation of RAP80 by the Cdk1-cyclin B(1) complex is important for RAP80 functional sensitivity to IR and G(2)/M checkpoint control. ..
  69. Even Y, Durieux S, Escande M, Lozano J, Peaucellier G, Weil D, et al. CDC2L5, a Cdk-like kinase with RS domain, interacts with the ASF/SF2-associated protein p32 and affects splicing in vivo. J Cell Biochem. 2006;99:890-904 pubmed
    ..Then, we report that CDC2L5 directly interacts with the ASF/SF2-associated protein p32, a protein involved in splicing regulation...
  70. Bressan G, Quaresma A, Moraes E, Manfiolli A, Passos D, Gomes M, et al. Functional association of human Ki-1/57 with pre-mRNA splicing events. FEBS J. 2009;276:3770-83 pubmed publisher
    ..In summary, our findings suggest that Ki-1/57 is probably involved in cellular events related to RNA functions, such as pre-mRNA splicing. ..
  71. Herwald H, Dedio J, Kellner R, Loos M, Muller Esterl W. Isolation and characterization of the kininogen-binding protein p33 from endothelial cells. Identity with the gC1q receptor. J Biol Chem. 1996;271:13040-7 pubmed
    ..NH2-terminal amino acid sequence analysis identified the kininogen-binding protein p33 as the gC1q receptor ("gC1qR"), an extrinsic membrane protein that interacts with the globular domains of the complement component C1q...
  72. Zheng Y, Yu H, Peterlin B. Human p32 protein relieves a post-transcriptional block to HIV replication in murine cells. Nat Cell Biol. 2003;5:611-8 pubmed
    ..cells, HIV transcripts are spliced excessively, a process that is not inhibited by the murine splicing inhibitor p32 (mp32)...
  73. Basu K, Sen A, Ray K, Ghosh I, Datta K, Mukhopadhyay A. Genetic association and gene-gene interaction of HAS2, HABP1 and HYAL3 implicate hyaluronan metabolic genes in glaucomatous neurodegeneration. Dis Markers. 2012;33:145-54 pubmed
    ..the single nucleotide polymorphisms (SNPs) of the HA synthesizing gene - hyaluronan synthase 2 (HAS2), hyaluronan binding protein 1 (HABP1) and HA catabolic gene hyaluronidase 3 (HYAL3) in the primary open angle glaucoma (POAG) ..
  74. Wu H, Sun H, Liang X, Lima W, Crooke S. Human RNase H1 is associated with protein P32 and is involved in mitochondrial pre-rRNA processing. PLoS ONE. 2013;8:e71006 pubmed publisher
    ..We identified the mitochondrial protein P32 that binds specifically to human RNase H1, but not human RNase H2...
  75. Mazziotti R, Lupori L, Sagona G, Gennaro M, Della Sala G, Putignano E, et al. Searching for biomarkers of CDKL5 disorder: early-onset visual impairment in CDKL5 mutant mice. Hum Mol Genet. 2017;26:2290-2298 pubmed publisher
    ..females, and their respective control wild-type littermates by repeated transcranial optical imaging from P27 until P32. No difference between wild-type and mutant mice was present at P25-P26 whereas defective responses appeared from ..
  76. Tsofack S, Garand C, Sereduk C, Chow D, Aziz M, Guay D, et al. NONO and RALY proteins are required for YB-1 oxaliplatin induced resistance in colon adenocarcinoma cell lines. Mol Cancer. 2011;10:145 pubmed publisher
    ..These results suggest knocking down NONO or RALY significant counteracts oxaliplatin resistance in colorectal cancers overexpressing the YB-1 protein. ..
  77. Zhang X, Wang F, Shen Q, Xie C, Liu Y, Pan J, et al. Structure Reconstruction of LyP-1: Lc(LyP-1) coupling by amide bond Inspires the Brain Metastatic Tumor Targeted Drug Delivery. Mol Pharm. 2017;: pubmed publisher
    ..can specifically bind to tumor cells and tumor lymphatics through the interaction with cell-surface protein p32/gC1qR. Lc(LyP-1), with the same sequence of LyP-1 by amide coupling, showed better cellular uptake and ..
  78. Vegh Z, Goyarts E, Rozengarten K, Mazumder A, Ghebrehiwet B. Maturation-dependent expression of C1q binding proteins on the cell surface of human monocyte-derived dendritic cells. Int Immunopharmacol. 2003;3:39-51 pubmed
    ..In this report, we show, for the first time, that human monocyte-derived DCs express two types of C1q receptors, gC1qR and cC1qR. Furthermore, immature DCs secrete detectable amount of C1q into the culture supernatant...
  79. Mahdi F, Shariat Madar Z, Todd R, Figueroa C, Schmaier A. Expression and colocalization of cytokeratin 1 and urokinase plasminogen activator receptor on endothelial cells. Blood. 2001;97:2342-50 pubmed
    The cellular localization of human cytokeratin 1 (CK1), urokinase plasminogen activator receptor (uPAR), and gC1qR, high-molecular-weight kininogen (HK)-binding proteins on endothelial cells, was determined...
  80. Ghebrehiwet B, CebadaMora C, Tantral L, Jesty J, Peerschke E. gC1qR/p33 serves as a molecular bridge between the complement and contact activation systems and is an important catalyst in inflammation. Adv Exp Med Biol. 2006;586:95-105 pubmed
    The receptor for the globular heads of C1q, gC1qR/p33, is a ubiquitously expressed protein, which is distributed both intracellularly and on the cell-surface protein...
  81. Leigh L, Ghebrehiwet B, Perera T, Bird I, Strong P, Kishore U, et al. C1q-mediated chemotaxis by human neutrophils: involvement of gClqR and G-protein signalling mechanisms. Biochem J. 1998;330 ( Pt 1):247-54 pubmed
    ..The collagen tail of C1q appeared to mediate chemotaxis. gC1qR, a C1q-binding protein, has recently been reported to participate in C1q-mediated chemotaxis of murine mast cells ..
  82. Jiang Y, Wu H, Liu J, Chen Y, Xie J, Zhao Y, et al. Increased breast cancer risk with HABP1/p32/gC1qR genetic polymorphism rs2285747 and its upregulation in northern Chinese women. Oncotarget. 2017;8:13932-13941 pubmed publisher
    Hyaluronic acid binding protein 1 (HABP1/p32/gC1qR) is overexpressed in breast cancer. However, it is unknown whether HABP1 gene polymorphisms affect breast cancer risk...
  83. Yoshikawa H, Komatsu W, Hayano T, Miura Y, Homma K, Izumikawa K, et al. Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to preribosome particles. Mol Cell Proteomics. 2011;10:M110.006148 pubmed publisher
    ..Here, we present evidence that p32, fibrillarin (FBL), and Nop52 play key roles in this separation step...
  84. Fausther Bovendo H, Vieillard V, Sagan S, Bismuth G, Debre P. HIV gp41 engages gC1qR on CD4+ T cells to induce the expression of an NK ligand through the PIP3/H2O2 pathway. PLoS Pathog. 2010;6:e1000975 pubmed publisher
    ..using immunoprecipitation, ELISA and blocking antibodies, we demonstrate that the 3S motif of HIV-1 gp41 binds to gC1qR on CD4(+) T cells...