C1GALT1

Summary

Gene Symbol: C1GALT1
Description: core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Alias: C1GALT, T-synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, B3Gal-T8, core 1 O-glycan T-synthase, core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1, core 1 beta3-Gal-T1
Species: human
Products:     C1GALT1

Top Publications

  1. Ju T, Cummings R. Protein glycosylation: chaperone mutation in Tn syndrome. Nature. 2005;437:1252 pubmed
  2. ARGUESO P, Guzman Aranguez A, Mantelli F, Cao Z, Ricciuto J, Panjwani N. Association of cell surface mucins with galectin-3 contributes to the ocular surface epithelial barrier. J Biol Chem. 2009;284:23037-45 pubmed publisher
    ..of mucin O-glycosylation using a stable tetracycline-inducible RNA interfering system to knockdown c1galt1 (T-synthase), a critical galactosyltransferase required for the synthesis of core 1 O-glycans, resulted in ..
  3. Perrine C, Ju T, Cummings R, Gerken T. Systematic determination of the peptide acceptor preferences for the human UDP-Gal:glycoprotein-alpha-GalNAc beta 3 galactosyltransferase (T-synthase). Glycobiology. 2009;19:321-8 pubmed publisher
    ..This work suggests that there are indeed subtle specific and nonspecific protein-targeting sequence motifs for this transferase. ..
  4. Ju T, Brewer K, D Souza A, Cummings R, Canfield W. Cloning and expression of human core 1 beta1,3-galactosyltransferase. J Biol Chem. 2002;277:178-86 pubmed
    ..The core 1 beta3-Gal-T sequence has minimal homology with conserved sequences found in previously described beta3-galactosyltransferases, suggesting this enzyme is only distantly related to the known beta3-galactosyltransferase family. ..
  5. Wu Y, Liu C, Huang M, Lai H, Lee P, Hu R, et al. C1GALT1 enhances proliferation of hepatocellular carcinoma cells via modulating MET glycosylation and dimerization. Cancer Res. 2013;73:5580-90 pubmed publisher
    Altered glycosylation is a hallmark of cancer. The core 1 ?1,3-galactosyltransferase (C1GALT1) controls the formation of mucin-type O-glycans, far overlooked and underestimated in cancer...
  6. Sahasrabudhe N, Lenos K, van der Horst J, Rodriguez E, van Vliet S. Oncogenic BRAFV600E drives expression of MGL ligands in the colorectal cancer cell line HT29 through N-acetylgalactosamine-transferase 3. Biol Chem. 2018;399:649-659 pubmed publisher
    ..enzymes involved in the synthesis or elongation of Tn antigen, N-acetylgalactosamine-transferases (GALNTs) and C1GalT1/COSMC, respectively...
  7. Soni K, Thomas D, Caffrey T, Mehla K, Lei F, O Connell K, et al. Polymeric Nanogel-based Treatment Regimen for Enhanced Efficacy and Sequential Administration of Synergistic Drug Combination in Pancreatic Cancer. J Pharmacol Exp Ther. 2019;: pubmed publisher
    ..due to the loss of function of COSMC, a specific chaperone for the activity of core 1 β3-galactosyltransferase or C1GalT. Here, we report the development of polymeric nanogels (NGs) loaded with CDDP and coated with an anti-STn antigen ..
  8. Grasa P, Kaune H, Williams S. Embryos generated from oocytes lacking complex N- and O-glycans have compromised development and implantation. Reproduction. 2012;144:455-65 pubmed publisher
    ..we investigate the basis of the small litter by evaluating ovulation rate and embryo development in DM (Mgat1(F/F)C1galt1(F/F):ZP3Cre) and Control (Mgat1(F/F)C1galt1(F/F)) females...
  9. Bolscher J, Brevoord J, Nazmi K, Ju T, Veerman E, van Wijk J, et al. Solid-phase synthesis of a pentavalent GalNAc-containing glycopeptide (Tn antigen) representing the nephropathy-associated IgA hinge region. Carbohydr Res. 2010;345:1998-2003 pubmed publisher
    ..Besides its immunochemical functionality as a possible diagnostic tool for IgA nephropathy, the peptide is an excellent substrate for glycan elongation and represents a novel template applicable for glycan-antigen-associated diseases. ..

More Information

Publications71

  1. Sun X, Ju T, Cummings R. Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers. BMC Cancer. 2018;18:827 pubmed publisher
    ..Our results demonstrate multiple mechanisms for Tn expression in CRCs. ..
  2. Grasa P, Ploutarchou P, Williams S. Oocytes lacking O-glycans alter follicle development and increase fertility by increasing follicle FSH sensitivity, decreasing apoptosis, and modifying GDF9:BMP15 expression. FASEB J. 2015;29:525-39 pubmed publisher
    ..Here we analyze the basis of this phenotype using Mutant [core 1 β1,3-galactosyltransferase 1 (C1galt1)(FF):zona pellucida glycoprotein 3 Cre (ZP3Cre)] and Control (C1galt1(FF)) female mice...
  3. Chugh S, Barkeer S, Rachagani S, Nimmakayala R, Perumal N, Pothuraju R, et al. Disruption of C1galt1 Gene Promotes Development and Metastasis of Pancreatic Adenocarcinomas in Mice. Gastroenterology. 2018;155:1608-1624 pubmed publisher
    ..Dysregulated activity of core 1 synthase glycoprotein-N-acetylgalactosamine 3-β-galactosyltransferase 1 (C1GALT1) leads to increased expression of these truncated O-glycans...
  4. Christensen A, Patel S, Grasa P, Christian H, Williams S. Oocyte glycoproteins regulate the form and function of the follicle basal lamina and theca cells. Dev Biol. 2015;401:287-98 pubmed publisher
    ..To investigate this role, we use a mouse model with oocyte-specific deletion of C1galt1 which is required for the generation of core 1-derived O-glycans...
  5. Wang Y, Liao X, Ye Q, Huang L. Clinic implication of MUC1 O-glycosylation and C1GALT1 in esophagus squamous cell carcinoma. Sci China Life Sci. 2018;61:1389-1395 pubmed publisher
    ..Moreover, we verified a potential link between MUC1 O-glycosylation and C1GALT1, which was further supported by IHC analysis on 38 ESCC and 19 para-carcinoma samples...
  6. Beatson R, Maurstad G, Picco G, Arulappu A, Coleman J, Wandell H, et al. The Breast Cancer-Associated Glycoforms of MUC1, MUC1-Tn and sialyl-Tn, Are Expressed in COSMC Wild-Type Cells and Bind the C-Type Lectin MGL. PLoS ONE. 2015;10:e0125994 pubmed publisher
    ..close proximity to extended glycan T (Galβ1,3GalNAc) the addition of Gal to the GalNAc being catalysed by the T synthase. The presence of active T synthase suggests that loss of the private chaperone for T synthase, COSMC, does not ..
  7. Shao J, Peng Y, He L, Liu H, Chen X, Peng X. Capsaicin induces high expression of BAFF and aberrantly glycosylated IgA1 of tonsillar mononuclear cells in IgA nephropathy patients. Hum Immunol. 2014;75:1034-9 pubmed publisher
    ..and IgA1 secretion were higher in IgAN patients than that in non-IgAN patients, meanwhile, the gene expression of C1GALT1 and Cosmc and IgA1 O-glycosylation level were significantly lower...
  8. Lin M, Chien P, Wu H, Chen S, Juan H, Lou P, et al. C1GALT1 predicts poor prognosis and is a potential therapeutic target in head and neck cancer. Oncogene. 2018;: pubmed publisher
    Core 1 β1,3-galactosyltransferase (C1GALT1) controls the crucial step of GalNAc-type O-glycosylation and is overexpressed in various human malignancies. However, its role in head and neck squamous cell carcinoma (HNSCC) remains unclear...
  9. Ploutarchou P, Melo P, Day A, Milner C, Williams S. Molecular analysis of the cumulus matrix: insights from mice with O-glycan-deficient oocytes. Reproduction. 2015;149:533-43 pubmed publisher
    ..In contrast to other in vivo models where modified expansion impairs fertility, the cumulus mass of C1galt1 Mutants, which have oocyte-specific deletion of core 1-derived O-glycans, is modified without impairing fertility...
  10. Xie Y, He L, Chen X, Peng X, Ye M, Zhao Y, et al. Potential diagnostic biomarkers for IgA nephropathy: a comparative study pre- and post-tonsillectomy. Int Urol Nephrol. 2016;48:1855-1861 pubmed
    The proteins BAFF, ST6GALNAC2, C1GALT1, and COSMC in peripheral blood mononuclear cells (PBMCs) and plasma levels of IgA1 and galactose-deficient IgA1 (Gd-IgA1) are potential biomarkers for IgAN nephropathy...
  11. Bergstrom K, Liu X, Zhao Y, Gao N, Wu Q, Song K, et al. Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice. Gastroenterology. 2016;151:152-164.e11 pubmed publisher
    ..DKO mice) and analyzed them, along with mice that singly lack intestinal epithelial core 1 O-glycans (IEC C1galt1(-/-) mice) or core 3 O-glycans (C3Gnt(-/-) mice)...
  12. Shao B, Yago T, Setiadi H, Wang Y, Mehta D souza P, Fu J, et al. O-glycans direct selectin ligands to lipid rafts on leukocytes. Proc Natl Acad Sci U S A. 2015;112:8661-6 pubmed publisher
    ..Here, we found that loss of core 1-derived O-glycans in murine C1galt1(-/-) neutrophils blocked raft targeting of PSGL-1, CD43, and CD44, but not of other glycosylated proteins, as ..
  13. Li Y, Fu J, Ling Y, Yago T, McDaniel J, Song J, et al. Sialylation on O-glycans protects platelets from clearance by liver Kupffer cells. Proc Natl Acad Sci U S A. 2017;114:8360-8365 pubmed publisher
    ..Here, we generated mice with a hematopoietic cell-specific loss of O-glycans (HC C1galt1-/- )...
  14. Milde Langosch K, Schütze D, Oliveira Ferrer L, Wikman H, Müller V, Lebok P, et al. Relevance of βGal-βGalNAc-containing glycans and the enzymes involved in their synthesis for invasion and survival in breast cancer patients. Breast Cancer Res Treat. 2015;151:515-28 pubmed publisher
    ..glycosylation enzymes involved in the synthesis of HPA and PNA binding glycostructures (GALNT family members and C1GALT1) was analyzed in microarray data of 194 carcinomas...
  15. Ho C, Lin C, Liaw Y, Chiang H, Chin Y, Huang R, et al. The cytokine-cosmc signaling axis upregulates the tumor-associated carbohydrate antigen Tn. Oncotarget. 2016;7:61930-61944 pubmed publisher
    ..Since Cosmc, a chaperone for T-synthase, is known to negatively regulate Tn levels, our results suggest elevated Tn levels in cancer and inflammation may be commonly regulated by the cytokine-Cosmc signaling axis. ..
  16. Gao N, Bergstrom K, Fu J, Xie B, Chen W, Xia L. Loss of intestinal O-glycans promotes spontaneous duodenal tumors. Am J Physiol Gastrointest Liver Physiol. 2016;311:G74-83 pubmed publisher
    ..Using mice lacking intestinal core 1- and core 3-derived O-glycans [intestinal epithelial cell C1galt1(-/-);C3GnT(-/-) or double knockout (DKO)], we found that loss of O-glycans predisposes DKO mice to spontaneous ..
  17. Ju T, Wang Y, Aryal R, Lehoux S, Ding X, Kudelka M, et al. Tn and sialyl-Tn antigens, aberrant O-glycomics as human disease markers. Proteomics Clin Appl. 2013;7:618-31 pubmed publisher
    ..This review will summarize our current understanding of the Tn and STn antigens in terms of their biochemistry and role in pathology. ..
  18. Hanes M, Moremen K, Cummings R. Biochemical characterization of functional domains of the chaperone Cosmc. PLoS ONE. 2017;12:e0180242 pubmed publisher
    ..Our results provide new structure-function insight to Cosmc, indicate that Cosmc behaves as a modular protein and suggests points of modulation or regulation of in vivo chaperone function. ..
  19. Tsai C, Tzeng S, Chao T, Tsai C, Yang Y, Lee M, et al. Metastatic Progression of Prostate Cancer Is Mediated by Autonomous Binding of Galectin-4-O-Glycan to Cancer Cells. Cancer Res. 2016;76:5756-5767 pubmed
    ..Notably, these effects of galectin-4 relied upon O-glycosylation mediated by C1GALT1, a galactosyltransferase implicated in other cancers...
  20. Itoh K, Akimoto Y, Kondo S, Ichimiya T, Aoki K, Tiemeyer M, et al. Glucuronylated core 1 glycans are required for precise localization of neuromuscular junctions and normal formation of basement membranes on Drosophila muscles. Dev Biol. 2018;436:108-124 pubmed publisher
    ..mucin-type core 1 glycan structure in animals synthesized by core 1 β1,3-galactosyltransferase 1 (C1GalT1)...
  21. Shi C, Xu X, Yu X, Du Z, Luan X, Liu D, et al. CD3/CD28 dynabeads induce expression of tn antigen in human t cells accompanied by hypermethylation of the cosmc promoter. Mol Immunol. 2017;90:98-105 pubmed publisher
    ..These data suggest that hypermethylation of the Cosmc promoter may induce the expression of Tn antigen in activated T cells. ..
  22. Yu X, Du Z, Sun X, Shi C, Zhang H, Hu T. Aberrant Cosmc genes result in Tn antigen expression in human colorectal carcinoma cell line HT-29. Int J Clin Exp Pathol. 2015;8:2590-602 pubmed
  23. Yang M, Li F, Xie X, Wang S, Fan J. CagA, a major virulence factor of Helicobacter pylori, promotes the production and underglycosylation of IgA1 in DAKIKI cells. Biochem Biophys Res Commun. 2014;444:276-81 pubmed publisher
    ..underglycosylation of IgA1, which at least partly attributed to the downregulation of ?1,3-galactosyltransferase (C1GALT1) and its chaperone Cosmc...
  24. Chou C, Huang M, Chen C, Shyu M, Huang J, Hung J, et al. Up-regulation of C1GALT1 promotes breast cancer cell growth through MUC1-C signaling pathway. Oncotarget. 2015;6:6123-35 pubmed
    Aberrant glycosylation is frequently observed in cancers. Core 1 β1,3-galactosyltransferase (C1GALT1) is an exclusive enzyme in humans that catalyzes the biosynthesis of core 1 O-glycan structure, Gal-GalNAc-O-Ser/Thr, whose ..
  25. Li G, Zhang H, Lv J, Shen Y, Wang H. Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy. Kidney Int. 2007;71:448-53 pubmed
    ..association study was performed to investigate the association between single-nucleotide polymorphisms (SNPs) of C1GALT1 and C1GALT1C1 genes and the susceptibility to IgAN...
  26. Xue J, Guo Y, Song X, Xue F, Yang S, Jiang H, et al. Relationship between rs1047763 polymorphism of the C1GALT1 gene and susceptibility to immunoglobulin A nephropathy in Xinjiang Uyghur people. Genet Mol Res. 2015;14:18687-94 pubmed publisher
    We explored the relationship between rs1047763, a single-nucleotide polymorphism (SNP) of the C1GALT1 gene, and genetic susceptibility to immunoglobulin A nephropathy (IgAN) in Xinjiang Uyghur people...
  27. Malycha F, Eggermann T, Hristov M, Schena F, Mertens P, Zerres K, et al. No evidence for a role of cosmc-chaperone mutations in European IgA nephropathy patients. Nephrol Dial Transplant. 2009;24:321-4 pubmed publisher
    ..The galactosyltransferase core-1 beta3-galactosyltransferase-1 (C1GALT1) and its chaperone cosmc are specifically required for O-galactosylation of the IgA1 hinge region...
  28. An J, Lu Q, Zhao H, Cao Y, Yan B, Ma Z. A study on the association between C1GALT1 polymorphisms and the risk of Henoch-Schönlein purpura in a Chinese population. Rheumatol Int. 2013;33:2539-42 pubmed publisher
    ..The purpose of this study is to investigate the association between polymorphisms in C1GALT1 gene and the risk of HSP in a Chinese population...
  29. Zhu L, Tang W, Li G, Lv J, Ding J, Yu L, et al. Interaction between variants of two glycosyltransferase genes in IgA nephropathy. Kidney Int. 2009;76:190-8 pubmed publisher
    ..We earlier found that haplotypes in two key glycosyltransferase genes, C1GALT1 and ST6GALNAC2, were associated with susceptibility to IgAN...
  30. Barrow H, Tam B, Duckworth C, Rhodes J, Yu L. Suppression of core 1 Gal-transferase is associated with reduction of TF and reciprocal increase of Tn, sialyl-Tn and Core 3 glycans in human colon cancer cells. PLoS ONE. 2013;8:e59792 pubmed publisher
    It has long been presumed, though with surprisingly little evidence, a competition between Core 1 Gal-transferase (C1GalT), Core 3 GlcNAc-transferase (C3GnT) and sialyl-transferase (ST6GalNAc-T) for elongation of O-linked mucin-type ..
  31. Narimatsu Y, Ikehara Y, Iwasaki H, Nonomura C, Sato T, Nakanishi H, et al. Immunocytochemical analysis for intracellular dynamics of C1GalT associated with molecular chaperone, Cosmc. Biochem Biophys Res Commun. 2008;366:199-205 pubmed
    ..T antigen), the major constituent of O-glycan core structure, is synthesized by cooperation of core 1 synthase (C1GalT) and its specific molecular chaperone, Cosmc...
  32. Jacobs J, Lin L, Goudarzi M, Ruegger P, McGovern D, Fornace A, et al. Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency. Gut Microbes. 2017;8:1-16 pubmed publisher
    ..We explored this question using mice with intestine-specific deletion of C1galt1 (also known as T-synthase) (Tsyn mice)...
  33. Nie R, Cheng G, Zhang J, Dong Y, Wang C, Liu J, et al. The Association of rs1047763 and rs1008898 of C1GALT1 with IgA Nephropathy Risk: A Global Meta-Analysis. Monoclon Antib Immunodiagn Immunother. 2017;36:95-103 pubmed publisher
    ..core 1 O-glycan structure by core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (C1GALT1), the key enzyme in the process of glycosylation...
  34. Ju T, Aryal R, Stowell C, Cummings R. Regulation of protein O-glycosylation by the endoplasmic reticulum-localized molecular chaperone Cosmc. J Cell Biol. 2008;182:531-42 pubmed publisher
  35. Bertinetto F, Calafell F, Roggero S, Chidichimo R, Garino E, Marcuccio C, et al. Search for genetic association between IgA nephropathy and candidate genes selected by function or by gene mapping at loci IGAN2 and IGAN3. Nephrol Dial Transplant. 2012;27:2328-37 pubmed publisher
    ..b>C1GALT1 showed an association with IgAN (rs1008898: P = 0.0019 and rs7790522: P = 0.0049)...
  36. Brockhausen I, Dowler T, Paulsen H. Site directed processing: role of amino acid sequences and glycosylation of acceptor glycopeptides in the assembly of extended mucin type O-glycan core 2. Biochim Biophys Acta. 2009;1790:1244-57 pubmed publisher
    ..initiated by polypeptide GalNAc-transferase (ppGalNAc-T), followed by the action of core 1 beta3-Gal-transferase (C1GalT) and core 2 beta6-GlcNAc-transferase (C2GnT)...
  37. Hung J, Huang J, Lin Y, Huang M, Lee P, Lai H, et al. C1GALT1 overexpression promotes the invasive behavior of colon cancer cells through modifying O-glycosylation of FGFR2. Oncotarget. 2014;5:2096-106 pubmed
    Core 1 ?1,3-galactosyltransferase (C1GALT1) transfers galactose (Gal) to N-acetylgalactosamine (GalNAc) to form Gal?1,3GalNAc (T antigen). Aberrant O-glycans, such as T antigen, are commonly found in colorectal cancer...
  38. Wang W, Sun Y, Fu Y, Yu X, Li M. Interaction of C1GALT1-IL5RA on the susceptibility to IgA nephropathy in Southern Han Chinese. J Hum Genet. 2013;58:40-6 pubmed publisher
    ..05). The MDR analysis showed a potential interaction of C1GALT1-330G/T (rs1008898) and IL5RA31+197A/G (rs340833) on the susceptibility of IgAN (P<0.001)...
  39. Aryal R, Ju T, Cummings R. The endoplasmic reticulum chaperone Cosmc directly promotes in vitro folding of T-synthase. J Biol Chem. 2010;285:2456-62 pubmed publisher
    ..Cosmc represents the first ER chaperone identified to be required for folding of a glycosyltransferase. ..
  40. Kaune H, Sheikh S, Williams S. Analysis of in vitro follicle development during the onset of premature ovarian insufficiency in a mouse model. Reprod Fertil Dev. 2017;29:1538-1544 pubmed publisher
    ..N-glycans due to deletion of core 1 synthase, glycoprotein-N-acetylgalactosamine 3-β-galactosyltransferase 1 (C1galt1) and mannoside acetylglucosaminyltransferase 1 (Mgat1) respectively (DM, C1galt1F/FMgat1F/F:..
  41. Chou C, Huang M, Liao Y, Chen C, Huang M. C1GALT1 Seems to Promote In Vitro Disease Progression in Ovarian Cancer. Int J Gynecol Cancer. 2017;27:863-871 pubmed publisher
    Aberrant glycosylation affects many cellular properties in cancers. The core 1 β1,3-galactosyltransferase (C1GALT1), an enzyme that controls the formation of mucin-type O-glycans, has been reported to regulate hepatocellular and mammary ..
  42. Chik J, Zhou J, Moh E, Christopherson R, Clarke S, Molloy M, et al. Comprehensive glycomics comparison between colon cancer cell cultures and tumours: implications for biomarker studies. J Proteomics. 2014;108:146-62 pubmed publisher
    ..associated with an increase in ?2,6-sialyltransferase gene (ST6GALNAC1) and a decrease in core 1 synthase gene (C1GALT1) in LS174T cells...
  43. Li W, Lu C. Association between C1GALT1 variants and genetic susceptibility to IgA nephropathy in Uygur. Genet Mol Res. 2015;14:5327-33 pubmed publisher
    ..carbohydrate moieties of IgA that may result from altered activity in the core of 1 b1,3-galactosyltransferase (C1GalT1)...
  44. Pirulli D, Crovella S, Ulivi S, Zadro C, Bertok S, Rendine S, et al. Genetic variant of C1GalT1 contributes to the susceptibility to IgA nephropathy. J Nephrol. 2009;22:152-9 pubmed
    ..carbohydrate moieties of IgA that may be a result of altered activity of core 1 beta1,3-galactosyltransferase (C1GalT1)...
  45. Lin Y, Reddy B, Irvine K. Requirement for a core 1 galactosyltransferase in the Drosophila nervous system. Dev Dyn. 2008;237:3703-14 pubmed publisher
    ..Lectin staining and blotting experiments confirmed that C1GalTA contributes to the synthesis of Gal-beta1,3-GalNAc in vivo. Our results identify a role for mucin-type O-glycosylation during neural development in Drosophila. ..
  46. Dong X, Luo Z, Wang Y, Meng L, Duan Q, Qiu L, et al. Altered O-glycosylation is associated with inherent radioresistance and malignancy of human laryngeal carcinoma. Exp Cell Res. 2018;362:302-310 pubmed publisher
    ..In addition, core 1 ?1, 3-galactosyltransferase (C1GALT1) overexpression in Hep-2min cells enhanced cell migration, invasion, and radioresistance...
  47. Kiryluk K, Li Y, Moldoveanu Z, Suzuki H, Reily C, Hou P, et al. GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway. PLoS Genet. 2017;13:e1006609 pubmed publisher
    ..in 2,633 subjects of European and East Asian ancestry and discovered two genome-wide significant loci, in C1GALT1 (rs13226913, P = 3.2 x 10-11) and C1GALT1C1 (rs5910940, P = 2.7 x 10-8)...
  48. Gale D, Molyneux K, Wimbury D, Higgins P, Levine A, Caplin B, et al. Galactosylation of IgA1 Is Associated with Common Variation in C1GALT1. J Am Soc Nephrol. 2017;28:2158-2166 pubmed publisher
    ..39. Genome-wide association analysis by linear regression identified alleles at a single locus spanning the C1GALT1 gene that strongly associated with Gd-IgA1 level (?=0.26; P=2.35×10-9)...
  49. Narimatsu Y, Kubota T, Furukawa S, Shimojima M, Iwasaki H, Tozawa Y, et al. Co-translational function of Cosmc, core 1 synthase specific molecular chaperone, revealed by a cell-free translation system. FEBS Lett. 2011;585:1276-80 pubmed publisher
    The core 1 structure of the mucin type O-glycan is synthesized by core 1 ?1,3-galactosyltransferase (C1GalT)...
  50. Christensen A, Peyrache E, Kaune H, Williams S. Formation of multiple-oocyte follicles in culture. In Vitro Cell Dev Biol Anim. 2017;53:791-797 pubmed publisher
    ..The FBL is modified in C1galt1 Mutant mice (C1galt1 FF:ZP3Cre) resulting from oocyte-specific deletion of C1galt1...
  51. Amado M, Almeida R, Schwientek T, Clausen H. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. Biochim Biophys Acta. 1999;1473:35-53 pubmed
  52. He X, Zhao P, Kang S, Ding Y, Luan J, Liu Z, et al. C1GALT1 polymorphisms are associated with Henoch-Schönlein purpura nephritis. Pediatr Nephrol. 2012;27:1505-9 pubmed publisher
    ..In order to examine the effects of C1GALT1 gene encoding core 1 ?1,3-galactosyltransferase, an important role in the ?1,3 glycosylation of IgA1, on HSPN ..
  53. Guzman Aranguez A, Woodward A, Pintor J, ARGUESO P. Targeted disruption of core 1 ?1,3-galactosyltransferase (C1galt1) induces apical endocytic trafficking in human corneal keratinocytes. PLoS ONE. 2012;7:e36628 pubmed publisher
    ..utilized a stable tetracycline-inducible RNA interfering system targeting the core 1 ß1,3-galactosyltransferase (C1galt1 or T-synthase), a critical galactosyltransferase required for the synthesis of core 1 O-glycans, to explore the ..
  54. Aryal R, Ju T, Cummings R. Tight complex formation between Cosmc chaperone and its specific client non-native T-synthase leads to enzyme activity and client-driven dissociation. J Biol Chem. 2012;287:15317-29 pubmed publisher
    ..Taken together, these results demonstrate a novel mechanism in which Cosmc cycles to bind non-native T-synthase, leading to enzyme activity and release in a client-driven process. ..
  55. Song K, Fu J, Song J, Herzog B, Bergstrom K, Kondo Y, et al. Loss of mucin-type O-glycans impairs the integrity of the glomerular filtration barrier in the mouse kidney. J Biol Chem. 2017;292:16491-16497 pubmed publisher
    ..of core 1-derived O-glycans is catalyzed by the glycosyltransferase core 1 β1,3-galactosyltransferase (C1galt1)...
  56. Grasa P, Sheikh S, Krzys N, Millar K, Janjua S, Nawaggi P, et al. Dysregulation of follicle development in a mouse model of premature ovarian insufficiency. Reproduction. 2016;152:591-601 pubmed
    ..mouse model of follicular POI, the Double Mutant (DM), arises from oocyte-specific deletion of Mgat1 and C1galt1 required for the generation of O- and N-glycans...
  57. Solatycka A, Owczarek T, Piller F, Piller V, Pula B, Wojciech L, et al. MUC1 in human and murine mammary carcinoma cells decreases the expression of core 2 ?1,6-N-acetylglucosaminyltransferase and ?-galactoside ?2,3-sialyltransferase. Glycobiology. 2012;22:1042-54 pubmed publisher
    ..We showed also that the overexpression of MUC1 in 4T1 cells changes their adhesive properties, as MUC1-expressing cells do not adhere to E-selectin, but bind galectin-3. ..
  58. Petrosyan A, Ali M, Cheng P. Glycosyltransferase-specific Golgi-targeting mechanisms. J Biol Chem. 2012;287:37621-7 pubmed publisher
    ..Herein, we investigate the Golgi-targeting mechanisms of core 1 ?3 galactosyltransferase (C1GalT1) and core 2 ?1,6-N-acetylglucosaminyltransferase-2 or mucus type (C2GnT-M), which participate in the early O-..
  59. Suzuki H, Raska M, Yamada K, Moldoveanu Z, Julian B, Wyatt R, et al. Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes. J Biol Chem. 2014;289:5330-9 pubmed publisher
    ..reduced galactosylation of the O-glycan substrate directly via decreased expression of the galactosyltransferase C1GalT1 and, indirectly, via increased expression of the sialyltransferase ST6GalNAc-II, which prevents galactosylation ..
  60. Liu C, Hu R, Huang M, Lai I, Chen C, Lai H, et al. C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin ?1 glycosylation and activity. PLoS ONE. 2014;9:e94995 pubmed publisher
    ..We previously reported that core 1 ?1,3-galactosyltransferase (C1GALT1) is frequently overexpressed in HCC tumors and its expression is associated with advanced tumor stage, metastasis,..
  61. Xiao J, Wang M, Xiong D, Wang Y, Li Q, Zhou J, et al. TGF-?1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 ?1, 3-galactosyltransferase and Cosmc. Mol Med Rep. 2017;15:969-974 pubmed publisher
    ..The mRNA levels of core1 ?1, 3-galactosyltransferase (C1GalT1) and its molecular chaperone, Cosmc, were analyzed, as was the subsequent O-glycosylation of IgA1, in a human B?..
  62. Zeng J, Mi R, Wang Y, Li Y, Lin L, Yao B, et al. Promoters of Human Cosmc and T-synthase Genes Are Similar in Structure, Yet Different in Epigenetic Regulation. J Biol Chem. 2015;290:19018-33 pubmed publisher
    ..These results are important in understanding the regulation of these genes that have roles in human diseases, such as IgA nephropathy and cancer. ..