BY55

Summary

Gene Symbol: BY55
Description: CD160 molecule
Alias: BY55, NK1, NK28, CD160 antigen, CD160 transmembrane isoform, CD160-delta Ig, natural killer cell receptor BY55, natural killer cell receptor, immunoglobulin superfamily member
Species: human

Top Publications

  1. pmc Electrophysiological evidence for different release mechanism of ATP and NO as inhibitory NANC transmitters in guinea-pig colon
    V Zagorodnyuk
    Department of Neuro muscular Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Br J Pharmacol 112:1077-82. 1994
  2. ncbi BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression
    Maria Nikolova
    INSERM 448, Faculté de Médecine de Créteil, 8 rue du General Sarrail, 94010, France
    Int Immunol 14:445-51. 2002
  3. ncbi Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes
    A Anumanthan
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 161:2780-90. 1998
  4. ncbi Cutting edge: engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset
    Aliz Barakonyi
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 563, Centre de Physiopathologie Toulouse Purpan, Toulouse, France
    J Immunol 173:5349-54. 2004
  5. pmc Mechanism of bradykinin-induced plasma extravasation in the rat knee joint
    H Cambridge
    Pharmacology Group, King s College London
    Br J Pharmacol 115:641-7. 1995
  6. pmc Inhibition of nitric oxide synthesis reveals non-cholinergic excitatory neurotransmission in the canine proximal colon
    C W Shuttleworth
    Department of Physiology, University of Nevada School of Medicine, Reno 89557
    Br J Pharmacol 109:739-47. 1993
  7. pmc Characterization of the capsaicin-sensitive component of cyclophosphamide-induced inflammation in the rat urinary bladder
    A Ahluwalia
    Department of Biochemical Pharmacology, William Harvey Research Institute, Medical College of St Bartholomew s Hospital, London, England
    Br J Pharmacol 111:1017-22. 1994
  8. pmc An investigation into the mechanism of capsaicin-induced oedema in rabbit skin
    P Newbold
    Pharmacology Group, King s College, London
    Br J Pharmacol 114:570-7. 1995
  9. pmc Depression of primary afferent-evoked responses by GR71251 in the isolated spinal cord of the neonatal rat
    J Z Guo
    Department of Pharmacology, Faculty of Medicine, Tokyo Medical University, Japan
    Br J Pharmacol 110:1142-8. 1993
  10. pmc Role of kinins in anaphylactic-induced bronchoconstriction mediated by tachykinins in guinea-pigs
    F L Ricciardolo
    Cardiovascular Research Institute, University of California San Francisco
    Br J Pharmacol 113:508-12. 1994

Detail Information

Publications158 found, 100 shown here

  1. pmc Electrophysiological evidence for different release mechanism of ATP and NO as inhibitory NANC transmitters in guinea-pig colon
    V Zagorodnyuk
    Department of Neuro muscular Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Br J Pharmacol 112:1077-82. 1994
    ..3 microM), the addition of the NK1 receptor antagonist, SR 140,333 (1 microM) abolished the non-adrenergic, non-cholinergic (NANC) excitatory junction ..
  2. ncbi BY55/CD160 acts as a co-receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression
    Maria Nikolova
    INSERM 448, Faculté de Médecine de Créteil, 8 rue du General Sarrail, 94010, France
    Int Immunol 14:445-51. 2002
    ..we examined the role of the recently identified glycosylphosphatidylinositol (GPI)-anchored cell surface molecule BY55, assigned as CD160, in TCR signaling...
  3. ncbi Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes
    A Anumanthan
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 161:2780-90. 1998
    Expression of the BY55 protein has been shown to be tightly associated with NK and CD8+ T lymphocytes with cytolytic effector activity. To determine the function of this protein, we molecularly cloned BY55 cDNA...
  4. ncbi Cutting edge: engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset
    Aliz Barakonyi
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 563, Centre de Physiopathologie Toulouse Purpan, Toulouse, France
    J Immunol 173:5349-54. 2004
    ..Thus, the CD160 receptor represents a unique triggering surface molecule expressed by cytotoxic NK cells that participates in the inflammatory response and determines the type of subsequent specific immunity...
  5. pmc Mechanism of bradykinin-induced plasma extravasation in the rat knee joint
    H Cambridge
    Pharmacology Group, King s College London
    Br J Pharmacol 115:641-7. 1995
    ..5. The selective neurokinin1 (NK1) receptor antagonist, RP67580 (230 nmol kg-1), or receptor antagonists for the mast cell products histamine and 5-..
  6. pmc Inhibition of nitric oxide synthesis reveals non-cholinergic excitatory neurotransmission in the canine proximal colon
    C W Shuttleworth
    Department of Physiology, University of Nevada School of Medicine, Reno 89557
    Br J Pharmacol 109:739-47. 1993
    ..contractions to EFS were enhanced by indomethacin (10 microM) and reduced or abolished by the non-selective NK1/NK2 tachykinin receptor antagonist D-Pro2, D-Trp7,9 SP, and by the selective NK2 receptor antagonist MEN 10,376 (10 ..
  7. pmc Characterization of the capsaicin-sensitive component of cyclophosphamide-induced inflammation in the rat urinary bladder
    A Ahluwalia
    Department of Biochemical Pharmacology, William Harvey Research Institute, Medical College of St Bartholomew s Hospital, London, England
    Br J Pharmacol 111:1017-22. 1994
    ..3. Intraperitoneal (i.p.) pretreatment with the tachykinin NK1 receptor antagonist, RP 67,580 (0.44 mg kg-1) or the bradykinin B2 receptor antagonist, Hoe 140 (0...
  8. pmc An investigation into the mechanism of capsaicin-induced oedema in rabbit skin
    P Newbold
    Pharmacology Group, King s College, London
    Br J Pharmacol 114:570-7. 1995
    ..However, oedema was not inhibited when capsaicin was co-injected with the neurokinin NK1 receptor antagonist, RP67580 (10 nmol), the NK2 antagonist SR48960 (10 nmol) or the CGRP antagonist CGRP8-37 (300 ..
  9. pmc Depression of primary afferent-evoked responses by GR71251 in the isolated spinal cord of the neonatal rat
    J Z Guo
    Department of Pharmacology, Faculty of Medicine, Tokyo Medical University, Japan
    Br J Pharmacol 110:1142-8. 1993
    ..The NK1 agonist, acetyl-Arg6-septide, and the NK3 agonist, senktide, at 0...
  10. pmc Role of kinins in anaphylactic-induced bronchoconstriction mediated by tachykinins in guinea-pigs
    F L Ricciardolo
    Cardiovascular Research Institute, University of California San Francisco
    Br J Pharmacol 113:508-12. 1994
    ..On the other hand, a combination of the NK1 (CP-96,345, 2 mumol kg-1, i.v.) and NK2 (SR 48968, 0.3 mumol kg-1, i.v...
  11. pmc The influence of the trigeminal ganglion on carotid blood flow in anaesthetized guinea-pigs
    D T Beattie
    Pharmacology II, Glaxo Research and Development Ltd, Ware, Herts
    Br J Pharmacol 112:262-6. 1994
    ..evoked by trigeminal ganglion stimulation were, however, unaffected by intravenous injection of the tachykinin NK1 receptor antagonists, GR82334 (0.3 mg kg-1) and CP-99,994 (0...
  12. pmc Characterization of the receptor and the mechanisms underlying the inflammatory response induced by des-Arg9-BK in mouse pleurisy
    R M Vianna
    Department of Pharmacology, Centre of Biological Sciences, Universidade Federal de Santa Catarina, , Brazil
    Br J Pharmacol 123:281-91. 1998
    ..4 An i.t. injection of the selective tachykinin receptor antagonists (NK1) FK 888 (1 nmol per site), (NK2) SR 48968 (20 nmol per site) or (NK3) SR 142801 (10 nmol per site), administered 5 ..
  13. pmc Mechanisms of bradykinin-induced contraction of the guinea-pig gallbladder in vitro
    D A Cabrini
    Universidade Federal de Santa Catarina, , Brazil
    Br J Pharmacol 114:1549-56. 1995
    ..1 microM, a selective leukotriene D4 receptor antagonist), tetrodotoxin(0.3microM), CP 96,345 (0.3 microM, a NK1 receptor antagonist), mepyramine (1 microM), glibenclamide (1 microM), H-7(3 microM), staurosporine (100 nM), or ..
  14. pmc The role of tachykinin NK1 and NK2 receptors in atropine-resistant colonic propulsion in anaesthetized guinea-pigs
    A Lecci
    Pharmacology Research Department, Menarini Ricerche S p A, Florence, Italy
    Br J Pharmacol 124:27-34. 1998
    ..endogenous tachykinins on guinea-pig colonic propulsion was investigated by using potent and selective tachykinin NK1 and NK2 receptor antagonists...
  15. pmc Modulatory effect of neuropeptide Y on acetylcholine-induced oedema and vasoconstriction in isolated perfused lungs of rabbit
    A Delaunois
    Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, , Belgium
    Br J Pharmacol 113:973-81. 1994
    ..and aspirin, an inhibitor of cyclo-oxygenase, while ketanserin, a 5-HT2 receptor antagonist, and SR140333, a new NK1 antagonist, had no protective effect...
  16. pmc Postjunctional inhibitory effect of the NK2 receptor antagonist, SR 48968, on sensory NANC bronchoconstriction in the guinea-pig
    Y P Lou
    Department of Pharmacology, Karolinska Institute, Stockholm, Sweden
    Br J Pharmacol 109:765-73. 1993
    ..The selective NK1 receptor antagonist, CP 96,345 (10(-6) M), together with SR 48968 completely abolished the remaining EFS-evoked ..
  17. pmc Modulation of excitatory amino acid responses by tachykinins and selective tachykinin receptor agonists in the rat spinal cord
    M J Cumberbatch
    Department of Physiology, University of Bristol, School of Medical Sciences
    Br J Pharmacol 115:1005-12. 1995
    ..2. The NK1-selective agonist, GR 73632, enhanced responses to all three EAAs similarly, whilst the NK2-selective agonist, ..
  18. pmc Endogenous tachykinins facilitate transmission through parasympathetic ganglia in guinea-pig trachea
    N Watson
    Department of Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 109:751-9. 1993
    ..effect of tachykinins has also been examined, by the use of selective tachykinin receptor agonists and a selective NK1 receptor antagonist. 2...
  19. pmc Pharmacological characterization of the contractile responses to angiotensin analogues in guinea-pig isolated longitudinal muscle of small intestine
    A B Hawcock
    Neuropharmacology Department, Glaxo Group Research Ltd, Ware, Hertfordshire
    Br J Pharmacol 108:1150-5. 1993
    ..Furthermore, while responses to these agonists were not significantly modified by the NK1 receptor antagonist (+/-)-CP-96,345 (30 nM) alone, the combined pre-incubation with both atropine and (+/-)-CP-96,..
  20. pmc Pharmacological analysis of the local and reflex responses to bradykinin on rat urinary bladder motility in vivo
    A Lecci
    Pharmacology Research Dept, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 114:708-14. 1995
    ..3. Intrathecal administration of the tachykinin NK1 receptor antagonists, RP 67,580 (10 nmol/rat) or SR 140,333 (10 nmol/rat), abolished the chemoceptive reflex ..
  21. pmc Evidence for a capsaicin-sensitive, tachykinin-mediated, component in the NANC contraction of the rat urinary bladder to nerve stimulation
    S Meini
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 112:1123-31. 1994
    ..4. The tachykinin NK1 receptor antagonist, SR 140,333 (0...
  22. pmc Calcitonin gene-related peptide (CGRP)-enhanced non-adrenergic non-cholinergic contraction of guinea-pig proximal colon
    S Kojima
    Department of Pharmacology, Dokkyo University School of Medicine, Tochigi, Japan
    Br J Pharmacol 115:1290-4. 1995
    ..3 microM), to block tachykinin NK1 and NK2 receptors, respectively. Thus, the EFS-induced NANC contractions are a tachykinin-mediated response. 3...
  23. pmc Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo
    Y Hirayama
    Department of Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 108:844-51. 1993
    1. We compared the effects of two novel tachykinin receptor antagonists, FK888 (selective at the tachykinin NK1 receptor) and FK224 (dual antagonist at NK1 and NK2 tachykinin receptors) on stimulus-evoked airway plasma exudation, ..
  24. pmc Tachykinin receptors in the guinea-pig renal pelvis: activation by exogenous and endogenous tachykinins
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 107:27-33. 1992
    1. The contractile response to substance P, neurokinin A, selective agonists for the NK1, NK2 and NK3 tachykinin receptors and the activity of receptor-selective antagonists has been investigated in circular muscle strips of the guinea-..
  25. pmc Effects of interactions of naturally-occurring neuropeptides on blood flow in the rat knee joint
    F Y Lam
    Institute of Physiology, University of Glasgow
    Br J Pharmacol 108:694-9. 1993
    ..5. Co-administration of 1 nmol of the specific NK1 receptor antagonist, CP-96345, with 1 nmol of each of the neurokinins produced significant inhibition of the ..
  26. pmc In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists
    A D Medhurst
    Department of Neurosciences Research, SmithKline Beecham Pharmaceuticals, Harlow, Essex
    Br J Pharmacol 122:469-76. 1997
    ..2 Hz) or substance P, exemplifying the selectivity of this class of antagonist for functional NK3 receptors over NK1 receptors in the rabbit. 6. In vivo, senktide (1, 10 and 25 microg i.v., i.e. 1.2, 11.9 and 29...
  27. pmc Evidence that tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitation and contraction in the circular muscle of guinea-pig duodenum
    V Zagorodnyuk
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 115:237-46. 1995
    ..2. The selective tachykinin (TK) NK1 receptor antagonist, GR 82,334 (30 nM-3 microM) produced a concentration-dependent inhibition of the EFS-evoked ..
  28. pmc Role of intrathecal tachykinins for micturition in unanaesthetized rats with and without bladder outlet obstruction
    O Ishizuka
    Department of Urology, Lund University Hospital, Sweden
    Br J Pharmacol 113:111-6. 1994
    1. The effects on micturition of RP 67,580, a selective NK1 receptor antagonist, and SR 48,968, a highly, potent antagonist at NK2 receptor sites, given intrathecally (i.t.) or intra-arterially (i.a...
  29. pmc The interaction of the NK1 receptor antagonist CP-96,345 with L-type calcium channels and its functional consequences
    S Guard
    Parke Davis Neuroscience Research Centre, Addenbrookes Hospital Site, Cambridge
    Br J Pharmacol 110:385-91. 1993
    1. We investigated the effects of the non-peptide NK1 receptor antagonist, CP-96,345, its inactive enantiomer CP-96,344, and the racemic mixture (+/-)-CP-96,345, on the binding of [3H]-nimodipine and [3H]-diltiazem to L-type calcium ..
  30. pmc Cardiovascular and behavioural effects of centrally administered tachykinins in the rat: characterization of receptors with selective antagonists
    P Picard
    Department of Physiology, Faculty of Medicine, , , Canada
    Br J Pharmacol 112:240-9. 1994
    1. The effects of intracerebroventricular (i.c.v.) injection of selective and potent NK1 (RP 67580), NK2 (SR 48968) and NK3 (R 486, [Trp7, beta-Ala8]NKA(4-10)) receptor antagonists were assessed on the cardiovascular and behavioural ..
  31. ncbi Specialization of tachykinin NK1 and NK2 receptors in producing fast and slow atropine-resistant neurotransmission to the circular muscle of the guinea-pig colon
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Neuroscience 63:1137-52. 1994
    We studied the relative contribution of tachykinin NK1 and NK2 receptors in producing nonadrenergic noncholinergic excitation of the circular muscle of the guinea-pig proximal colon in response to electrical field stimulation...
  32. ncbi [Mechanism of action of antidepressant drugs: importance of genetically modified mice in the pharmacological in vivo approach]
    Alain Gardier
    Laboratoire de Neuropharmacologie EA3544, Faculte de Pharmacie, Universite Paris Sud, Chatenay Malabry, France
    Therapie 60:469-76. 2005
    ..The study of substance P (neurokinin 1 receptor [R-NK1]) offers another example of the use of KO mice in the development of a new class of antidepressant drugs...
  33. pmc Identification of both NK1 and NK2 receptors in guinea-pig airways
    K T McKee
    Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, Pointe Claire, Dorval, , Canada
    Br J Pharmacol 110:693-700. 1993
    1. NK1 and NK2 receptors have been characterized in guinea-pig lung membrane preparations by use of [125I-Tyr8]-substance P and [125I]-neurokinin A binding assays in conjunction with tachykinin-receptor selective agonists ([Sar9Met(O2)11]..
  34. pmc Delayed-type hypersensitivity-induced increase in vascular permeability in the mouse small intestine: inhibition by depletion of sensory neuropeptides and NK1 receptor blockade
    A D Kraneveld
    Department of Pharmacology, Utrecht University, The Netherlands
    Br J Pharmacol 114:1483-9. 1995
    1. This study investigates the effects of capsaicin-induced depletion of sensory neuropeptides and of neurokinin1 (NK1) receptor blockade on delayed-type hypersensitivity (DTH)-induced changes of vascular permeability in the small ..
  35. ncbi Sequential activation of the triple excitatory transmission to the circular muscle of guinea-pig colon
    C A Maggi
    Pharmacology Department, Menarini Ricerche, Florence, Italy
    Neuroscience 79:263-74. 1997
    ..colon that occurs in response to activation of the intrinsic excitatory nerves by using atropine and tachykinin NK1 and NK2 receptor selective antagonists to define the relative contribution of the transmitters involved...
  36. pmc Tachykinin NK1 and NK2 receptor antagonists and atropine-resistant ascending excitatory reflex to the circular muscle of the guinea-pig ileum
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 112:161-8. 1994
    1. The aim of this study was to investigate the effect of various antagonists, selective for the tachykinin NK1 or NK2 receptor, on the atropine-resistant ascending excitatory reflex (AER) to the circular muscle of the guinea-pig ileum ..
  37. pmc Comparison of tachykinin NK1 and NK2 receptors in the circular muscle of the guinea-pig ileum and proximal colon
    C A Maggi
    Pharmacology and Chemistry Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 112:150-60. 1994
    1. The aim of this study was the pharmacological characterization of tachykinin NK1 and NK2 receptors mediating contraction in the circular muscle of the guinea-pig ileum and proximal colon...
  38. pmc Tachykininergic transmission to the circular muscle of the guinea-pig ileum: evidence for the involvement of NK2 receptors
    L Bartho
    Department of Pharmacology, University Medical School of Pecs, Hungary
    Br J Pharmacol 105:805-10. 1992
    1. The effect of newly developed, receptor-selective tachykinin antagonists (GR 71,251 for NK1 receptors, MEN 10,376 and L 659,877 for NK2 receptors) on noncholinergic transmission to the circular muscle of the guinea-pig ileum has been ..
  39. pmc Differences in the distribution and characteristics of tachykinin NK1 binding sites between human and guinea pig lung
    D A Walsh
    Department of Histochemistry, Royal Postgraduate Medical School, Hammersmith Hospital, London
    Br J Pharmacol 113:1407-15. 1994
    1. The distribution and characteristics of tachykinin NK1 binding sites have been compared in human and guinea pig lung using quantitative in vitro receptor autoradiography with [125I]-Bolton Hunter-labelled substance P ([125I]-BH-SP)...
  40. pmc Typical and atypical NK1 tachykinin receptor characteristics in the rabbit isolated iris sphincter
    J M Hall
    Biomedical Sciences Division, King s College London, Chelsea
    Br J Pharmacol 112:985-91. 1994
    1. A contraction of the rabbit isolated iris sphincter smooth muscle follows activation of either tachykinin NK1 or NK3 receptors...
  41. pmc Tachykinin NK1 receptor in the guinea-pig isolated proximal urethra: characterization by receptor selective agonists and antagonists
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 106:888-92. 1992
    ..Substance P (EC50 155 nM) was slightly (3.6 times) more potent than neurokinin A (EC50 560 nM). 3. The tachykinin NK1 receptor selective agonist, [Sar9]substance P sulphone (EC50 62 nM), was slightly more potent than substance P and ..
  42. pmc Effect of the tachykinin NK1 receptor antagonists, RP 67580 and SR 140333, on electrically-evoked substance P release from rat spinal cord
    M Malcangio
    Department of Pharmacology, School of Pharmacy, London
    Br J Pharmacol 113:635-41. 1994
    1. The effects of the non-peptide tachykinin NK1 receptor antagonists, RP 67580, SR 140333, CP-96,345 and CP-99,994 have been investigated on electrically-evoked release of substance P-like immunoreactivity (SP-LI) from rat spinal cord ..
  43. pmc Effects of RP 67580, a tachykinin NK1 receptor antagonist, on a primary afferent-evoked response of ventral roots in the neonatal rat spinal cord
    R Hosoki
    Department of Pharmacology, Faculty of Medicine, Tokyo Medical and Dental University, Japan
    Br J Pharmacol 113:1141-6. 1994
    1. The pharmacological characteristics of RP 67580, a non-peptide tachykinin NK1 receptor antagonist, and its effects on a reflex response evoked by stimulation of primary afferent fibres, were examined in isolated neonatal spinal cord ..
  44. ncbi Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice
    Peter G E Kennedy
    Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, UK
    Brain 126:1683-90. 2003
    ..We investigated the effect of disrupting the gene encoding for the NK1 receptor in mice on the clinical and neuroinflammatory response in this model...
  45. pmc Tachykinin receptors in rabbit airways--characterization by functional, autoradiographic and binding studies
    J L Black
    Department of Pharmacology, University of Sydney, NSW, Australia
    Br J Pharmacol 107:429-36. 1992
    1. In many species, both NK1 and NK2 tachykinin receptors appear to be important in mediating the contraction of airway smooth muscle...
  46. pmc Subtypes of tachykinin receptors on tonic and phasic neurones in coeliac ganglion of the guinea-pig
    F Y Zhao
    Department of Pharmacology, Faculty of Medicine, Tokyo Medical and Dental University, Japan
    Br J Pharmacol 115:25-30. 1995
    ..5. GR71251 (5 microM), an NK1-selective tachykinin receptor antagonist, depressed the depolarization in tonic neurones and the LAH inhibition in ..
  47. pmc Tachykinin NK1 but not NK2 receptors mediate non-cholinergic excitatory junction potentials in the circular muscle of guinea-pig colon
    V Zagorodnyuk
    Department Neuro muscular Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Br J Pharmacol 110:795-803. 1993
    1. The effect of tachykinin NK1 and NK2 receptor antagonists on noncholinergic excitatory junction potentials (e.j...
  48. pmc Cardiovascular and behavioural effects of intracerebroventricularly administered tachykinin NK3 receptor antagonists in the conscious rat
    E Cellier
    Department of Physiology, Faculty of Medicine, , , Canada
    Br J Pharmacol 122:643-54. 1997
    ..to affect the central cardiovascular and behavioural responses induced by 10 pmol [Sar9, Met(O2)11]substance P, a NK1 receptor selective agonist. The senktide-induced behavioural changes were not inhibited by R820 (6.5 nmol, i.c.v...
  49. ncbi Radioiodinated substance P, neurokinin A, and eledoisin bind predominantly in NK1 receptors in guinea pig lung
    D P Geraghty
    Department of Biological Sciences, Deakin University, Victoria, Australia
    Mol Pharmacol 41:147-53. 1992
    ..scyliorhinin II much greater than neuropeptide K, indicating binding to sites with the general characteristics of NK1 receptors...
  50. doi Efficacy and safety of casopitant mesylate, a neurokinin 1 (NK1)-receptor antagonist, in prevention of chemotherapy-induced nausea and vomiting in patients receiving cisplatin-based highly emetogenic chemotherapy: a randomised, double-blind, placebo-contr
    Steven M Grunberg
    University of Vermont, Burlington, VT 05405, USA
    Lancet Oncol 10:549-58. 2009
    ....
  51. ncbi Functional characterisation of tachykinin receptors mediating ion transport in porcine jejunum
    J E Thorbøll
    Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Eur J Pharmacol 359:271-9. 1998
    ..The non-peptide NK1 receptor antagonist, CP 99,994 ((2S,3S)-3-(2-methoxybenzyl)amino-2-phenylpiperidine), caused a dextral shift of the ..
  52. pmc Demonstration of a 'septide-sensitive' inflammatory response in rat skin
    A Ahluwalia
    Department of Biochemical Pharmacology, Medical College of St Bartholomew s Hospital, London
    Br J Pharmacol 116:2170-4. 1995
    ..The selective NK1 receptor agonist, [Sar9]SP sulphone was 10-100 times more potent than SP...
  53. pmc Facilitatory effects of selective agonists for tachykinin receptors on cholinergic neurotransmission: evidence for species differences
    M G Belvisi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 111:103-10. 1994
    ..6 +/- 121%, P < 0.01 and 181.4 +/- 56.5%, P < 0.001 respectively). 4. The NK1 receptor selective agonist, [Sar9]SP sulphone (10 nM) evoked a maximal facilitatory action on cholinergic responses ..
  54. pmc Antinociceptive activity of the tachykinin NK1 receptor antagonist, CP-99,994, in conscious gerbils
    N M Rupniak
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex
    Br J Pharmacol 116:1937-43. 1995
    ..enantiomer, CP-100,263, to inhibit spontaneous behaviours and hyperalgesia induced by central infusion of the NK1 receptor agonist, GR73632 or intraplantar injection of formalin was investigated in rats and gerbils. 2...
  55. pmc Characterization of NK1 and NK2 tachykinin receptors in guinea-pig and rat bronchopulmonary and vascular systems
    A Floch
    Rhone Poulenc Rorer S A, Centre de Recherche de Vitry Alfortville, Vitry sur Seine, France
    Br J Pharmacol 111:759-68. 1994
    1. NK1 and NK2 tachykinin receptors were characterized in guinea-pig and rat bronchopulmonary systems and in the vasculature of the rat by use of radioligand binding and/or functional studies. 2...
  56. ncbi Effects of selective tachykinin receptor antagonists on capsaicin- and tachykinin-induced bronchospasm in anaesthetized guinea-pigs
    L Ballati
    Pharmacology Department, Istituto Farmacobiologico Malesci S p A, Firenze, Italy
    Eur J Pharmacol 214:215-21. 1992
    ..capsaicin or selective tachykinin receptor agonists ([Sar9]SP sulfone or [beta-Ala8]neurokinin A (NKA-4-10)) (for NK1 and NK2 receptors, respectively) was studied in anaesthetized guinea-pigs...
  57. pmc Characterization of receptors for kinins and neurokinins in the arterial and venous mesenteric vasculatures of the guinea-pig
    N Berthiaume
    Department of Pharmacology, Medical School, , , Canada
    Br J Pharmacol 115:1319-25. 1995
    ..2. The vasoactive properties of three selective agonists for neurokinin receptors, namely [Sar9, Met (O2)11]SP (NK1), [beta-Ala8]NKA(4-10) (NK2) and [MePhe7]NKB (NK3), were evaluated on precontracted arterial and venous mesenteric ..
  58. ncbi The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity
    Y Tian
    Department of Biotechnology, Parke Davis Pharmaceutical Research, Division of Warner Lambert Co, Ann Arbor, Michigan 48105 1047, USA
    J Biol Chem 271:20250-7. 1996
    Three chimeric receptors were constructed by exchanging exon sequences between human NK1 and NK3 receptor genes...
  59. ncbi TRPV1 gene knockout impairs postischemic recovery in isolated perfused heart in mice
    Lihong Wang
    Department of Cardiovascular Sciences, First Affiliated Hospital, College of Medicine, Zhejiang University, China
    Circulation 112:3617-23. 2005
    ....
  60. pmc A non-peptide NK1-receptor antagonist, RP 67580, inhibits neurogenic inflammation postsynaptically
    S M Moussaoui
    Rhone Poulenc Rorer, Centre de Recherche de Vitry Alfortville, Vitry sur Seine, France
    Br J Pharmacol 109:259-64. 1993
    1. The non-peptide neurokinin NK1-receptor antagonist, RP 67580 (3aR, 7aR), a perhydroisoindolone derivative, powerfully reduced plasma extravasation in rat hind paw skin induced by local application of xylene (ID50 = 0.03 mg kg-1, i.v...
  61. ncbi The tachykinin NK1 receptor in the brain: pharmacology and putative functions
    A Saria
    Department of Psychiatry, University Hospital Innsbruck, Austria
    Eur J Pharmacol 375:51-60. 1999
    ..The receptors described so far are named tachykinin NK1 receptor, tachykinin NK2 receptor and tachykinin NK1 receptor, respectively...
  62. ncbi Increased blocking activity of combined tachykinin NK1- and NK2-receptor antagonists on hyperventilation-induced bronchoconstriction in the guinea pig
    M R Corboz
    Pulmonary and Peripheral Neurobiology, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Pulm Pharmacol Ther 21:67-72. 2008
    In vivo anesthetized guinea pigs were used to investigate the effect of tachykinin NK1- and NK2-receptor antagonists, as a single dose or in combination, against hyperventilation-induced bronchoconstriction (HIB)...
  63. ncbi Tachykinin NK1 and NK2 receptors mediate non-adrenergic non-cholinergic excitatory neuromuscular transmission in the human ileum
    V Zagorodnyuk
    Department of Neuro muscular Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Neuropeptides 31:265-71. 1997
    Tachykinin NK1 and NK2 receptor selective antagonists and agonists were used to study excitatory non-adrenergic non-cholinergic (NANC) transmission in circular muscle strips from human ileum by the sucrose-gap method...
  64. ncbi Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice
    S W Christianson
    Jackson Laboratory, Bar Harbor, Maine
    Cell Immunol 171:186-99. 1996
    ..C57BL/6J-scid/scid mice showed severe loss of mature T and B cells accompanied by increased percentages of NK1.1+ cells and myeloid cells...
  65. ncbi Role of tachykinins in the regulation of the hypothalamo-pituitary-adrenal axis
    G G Nussdorfer
    Department of Anatomy, University of Padua, Italy
    Peptides 19:949-68. 1998
    ..are a family of neuropeptides, which act by binding to three main subtypes of G protein-coupled receptors, named NK1, NK2 and NK3...
  66. ncbi Pharmacological characterization of GR82334, a tachykinin NK1 receptor antagonist, in the isolated spinal cord of the neonatal rat
    J Z Guo
    Department of Pharmacology, Faculty of Medicine, Tokyo Medical and Dental University, Japan
    Eur J Pharmacol 281:49-54. 1995
    ..Pharmacological characteristics of [D-Pro9,[spiro-gamma-lactam]Leu10,Trp11]physalaemin-(1-11) (GR82334), a tachykinin NK1 receptor antagonist, and its effects on slow depolarizing responses of lumbar ventral roots evoked by primary ..
  67. ncbi Changes in the populations of null, NK1.1+, and Thy1lo lymphocytes in the bone marrow of tumor-bearing mice: effect of indomethacin treatment
    M D Rahal
    Department of Anatomy, McGill University, Montreal, Quebec, Canada
    Cell Immunol 139:218-28. 1992
    ..A subset of these cells expresses the natural killer (NK) cell marker, NK1.1. In addition, some rapidly renewed bone marrow lymphocytes express low intensities of Thy1 (Thy1lo)...
  68. ncbi Species differences in tachykinin receptor distribution: further evidence that the substance P (NK1) receptor predominates in human brain
    Michael Rigby
    In Vivo Neuroscience, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, United Kingdom
    J Comp Neurol 490:335-53. 2005
    ..We compared the distribution of NK1, NK2, and NK3 receptors in sections from rodent, primate, and human brain using the 125I-labeled ligands substance ..
  69. ncbi Expression of substance P, neurokinin 1 receptors (NK1) and neurokinin 3 receptors in the developing mouse retina and in the retina of NK1 knockout mice
    E Catalani
    Dipartimento di Scienze Ambientali, Universita della Tuscia, Largo dell Università snc, Blocco D, 01100 Viterbo, Italy
    Neuroscience 138:487-99. 2006
    ..The observations in neurokinin 1 receptor knockout mice may not be applicable to rats or rabbits, and substance P and neurokinin 1 receptor may play different developmental roles in different species...
  70. doi Protein kinase C-mediated inhibition of recombinant T-type Cav3.2 channels by neurokinin 1 receptors
    Azahel Rangel
    Departamento de Fisiologia, Universidad Autonoma de San Luis Potosi, Av Venustiano Carranza, San Luis Potosi, Mexico
    Mol Pharmacol 77:202-10. 2010
    The voltage-activated T-type calcium channel (Ca(V)3.2) and the G protein-coupled neurokinin 1 (NK1) receptor are expressed in peripheral tissues and in central neurons, in which they participate in diverse physiological processes, ..
  71. ncbi The liver as a crucial organ in the first line of host defense: the roles of Kupffer cells, natural killer (NK) cells and NK1.1 Ag+ T cells in T helper 1 immune responses
    S Seki
    Division of Basic Traumatology, National Defense Medical College Research Institute, Tokorozawa, Japan
    Immunol Rev 174:35-46. 2000
    ..IL-12 and other monokines (IL- 18 etc.) produced by Kupffer cells activate liver natural killer (NK) cells and NK1.1 Ag+ T cells to produce interferon-gamma and thereby acquire cytotoxicity against tumors and microbe-infected ..
  72. ncbi Relationship between capsaicin-evoked substance P release and neurokinin 1 receptor internalization in the rat spinal cord
    J C G Marvizón
    Department of Medicine, David Geffen School of Medicine at UCLA, MRL 1240, 675 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 118:535-45. 2003
    ..Substance P release is usually measured by radioimmunoassay, whereas the internalization of the neurokinin 1 (NK1) receptor has been used to assess its activation by noxious stimuli...
  73. ncbi GR 73,632 and [Glu(OBzl)11]substance P are selective agonists for the septide-sensitive tachykinin NK1 receptor in the rat urinary bladder
    S Meini
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Neuropeptides 28:99-106. 1995
    The existence of a septide-sensitive subtype of the tachykinin NK1 receptor has been recently proposed...
  74. pmc Stimulation of angiogenesis by substance P and interleukin-1 in the rat and its inhibition by NK1 or interleukin-1 receptor antagonists
    T P Fan
    Department of Pharmacology, University of Cambridge
    Br J Pharmacol 110:43-9. 1993
    ..2. By use of selective tachykinin NK1, NK2 and NK3 receptor agonists, ([Sar9,Met(O2)11]substance P, [beta-Ala8]neurokinin A(4-10), Succ-[Asp6,MePhe8]..
  75. ncbi NK1, NK2, NK3 and CGRP1 receptors identified in rat oral soft tissues, and in bone and dental hard tissue cells
    I Fristad
    Department of Odontology Endodontics, School of Dentistry, University of Bergen, Arstadveien 17, 5009, Bergen, Norway
    Cell Tissue Res 311:383-91. 2003
    The distribution of the tachykinin receptors neurokinin-1 (NK1), neurokinin-2 (NK2) and neurokinin-3 (NK3), and the calcitonin gene-related peptide-1 (CGRP1) receptor were examined in rat teeth and tooth-supporting tissues by ..
  76. pmc Targeted deletion of neurokinin-1 receptor expressing nucleus tractus solitarii neurons precludes somatosensory depression of arterial baroreceptor-heart rate reflex
    J T Potts
    Department of Biomedical Science, College of Veterinary Medicine, Dalton Cardiovascular Research Center, University of Missouri, 134 Research Park Drive, Columbia, MO 65211, USA
    Neuroscience 145:1168-81. 2007
    Neurokinin-1 receptor (NK1-R) expressing neurons are densely distributed throughout the nucleus tractus solitarii (NTS). However, their fundamental role in arterial baroreflex function remains debated...
  77. ncbi Cellular localization and distribution of neurokinin-1 receptors in the rat stomach
    Linda Yip
    Department of Physiology, University of British Columbia, 2146 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
    Auton Neurosci 104:95-108. 2003
    In the stomach, the majority of substance P's effects are mediated by the activation of neurokinin-1 (NK1) receptors...
  78. ncbi NK1.1+ cells and T-cell activation in euthymic and thymectomized C57Bl/6 mice during acute Trypanosoma cruzi infection
    F Cardillo
    Department of Immunology, Institute for Biomedical Sciences IV, University of Sao Paulo, 05508 900 USP, Sao Paulo, SP, Brazil
    Scand J Immunol 55:96-104. 2002
    ..killer (NK) cells may provide the basis for resistance to Trypanosoma cruzi infection, because the depletion of NK1.1 cells causes high levels of parasitemia in young C57Bl/6 mice infected with T. cruzi. Indeed, NK1...
  79. pmc Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists
    Nissar A Darmani
    Department of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA
    Brain Res 1214:58-72. 2008
    Substance P (SP) is thought to play a cardinal role in emesis via the activation of central tachykinin NK1 receptors during the delayed phase of vomiting produced by chemotherapeutics...
  80. ncbi Substance P (NK1) receptor in relation to substance P innervation in rat duodenum after irradiation
    U Höckerfelt
    Department of Integrative Medical Biology, Anatomy, Umea University, SE 901 87, Umea, Sweden
    Regul Pept 98:115-26. 2001
    ..In the present study the pattern of distribution of NK1 receptors (NK1-R) in rat duodenum after irradiation (5-30 Gy), was examined at the same time-point (7 days) after ..
  81. ncbi Dual tachykinin NK1/NK2 antagonist DNK333 inhibits neurokinin A-induced bronchoconstriction in asthma patients
    G F Joos
    Dept of Respiratory Diseases, Ghent University Hospital, Belgium
    Eur Respir J 23:76-81. 2004
    Inhalation of neurokinin A (NKA) causes bronchoconstriction in patients with asthma. In vitro both tachykinin NK1 and NK2 receptors can mediate airway contraction...
  82. ncbi Involvement of spinal tachykinin NK1 and NK2 receptors in detrusor hyperreflexia during chemical cystitis in anaesthetized rats
    A Lecci
    Pharmacology Research Department Menarini Pharmaceuticals, Florence, Italy
    Eur J Pharmacol 259:129-35. 1994
    ..Intrathecal administration of the selective tachykinin NK1 receptor antagonist, GR 82,334 ([D-Pro9(spiro-gamma-lactam)Leu10,Trp11]physalaemin-(1-11)) (1 nmol/rat i.t...
  83. pmc Effect of RP 67580, a non-peptide neurokinin1 receptor antagonist, on facilitation of a nociceptive spinal flexion reflex in the rat
    J M Laird
    Department of Pharmacology, Merck, Sharp and Dohme Research Laboratories, Harlow, Essex
    Br J Pharmacol 109:713-8. 1993
    1. In order to examine the contribution of neurokinin1 (NK1) receptors to facilitation of a spinal nociceptive reflex in the rat, we have investigated the effects of RP 67580 (3aR, 7aR)-7,7-diphenyl-2(1-imino-2-(2-methoxyphenyl/ethyl)..
  84. ncbi Protein kinase C-mediated desensitization of the neurokinin 1 receptor
    O Dery
    Departments of Surgery and Physiology, University of California San Francisco, San Francisco, California 94143 0660, USA
    Am J Physiol Cell Physiol 280:C1097-106. 2001
    An understanding of the mechanisms that regulate signaling by the substance P (SP) or neurokinin 1 receptor (NK1-R) is of interest because of their role in inflammation and pain...
  85. doi Critical role of TCR specificity in the development of Vγ1Vδ6.3+ innate NKTγδ cells
    Pablo Pereira
    Institut Pasteur, Unité Lymphopoïese, Inserm U668, Paris 75724, France
    J Immunol 191:1716-23. 2013
    ..Surprisingly, both promyelocytic leukemia zinc finger (PLZF)(+) and NK1.1(+) NKTγδ cells were found in the thymus of Tg-γδ albeit at lower numbers than in Tg-γ mice, and virtually ..
  86. ncbi Ava[L-Pro9,N-MeLeu10] substance P(7-11) (GR 73632) and Sar9, Met(O2)11 increase distention-induced peristalsis through activation of neurokinin-1 receptors on smooth muscle and interstitial cells of cajal
    Florentine Nieuwmeyer
    Intestinal Disease Research Program, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Pharmacol Exp Ther 317:439-45. 2006
    ..an excitatory neurotransmitter related to gut motor activity, although an inhibitory influence of neurokinin-1 (NK1) receptor activation on peristalsis has also been reported...
  87. ncbi Successful virtual screening for a submicromolar antagonist of the neurokinin-1 receptor based on a ligand-supported homology model
    Andreas Evers
    Institut fur Pharmazeutische Chemie, Philipps Universitat Marburg, Marbacher Weg 6, 35032 Marburg, Germany
    J Med Chem 47:5381-92. 2004
    The neurokinin-1 (NK1) receptor belongs to the family of G-protein-coupled receptors (GPCRs), which represents one of the most relevant target families in small-molecule drug design...
  88. pmc CD160Ig fusion protein targets a novel costimulatory pathway and prolongs allograft survival
    Francesca D'Addio
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e60391. 2013
    ..Thus, CD160 signaling is particularly important in CD28-independent effector/memory CD8(+) alloreactive T cell activation in vivo and therefore may serve as a novel target for prevention of allograft rejection...
  89. ncbi Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an in vivo microdialysis study in mice
    Bruno P Guiard
    Laboratoire de Neuropharmacologie EA 3544 MJENR, Faculté de Pharmacie IFR75 Institut de Signalisation et d Innovation Thérapeutique, Universite Paris Sud, Chatenay Malabry, France
    J Neurochem 89:54-63. 2004
    Abstract Substance P antagonists of the neurokinin-1 receptor type (NK1) are gaining growing interest as new antidepressant therapies...
  90. ncbi Pregnancy-induced changes in substance P and neurokinin 1 receptor (NK1-R) expression in the rat uterus
    C Schmidt
    Institute of Anatomy, University of Leipzig, Liebigstrasse 13, Leipzig D 04103, Germany
    Reproduction 126:451-8. 2003
    ..behaviour of peptidergic fibres, such as substance P-positive fibres and of its preferred neurokinin 1 receptor (NK1-R), is poorly studied in the pregnant rat uterus...
  91. doi Innate NKTγδ and NKTαβ cells exert similar functions and compete for a thymic niche
    Pablo Pereira
    Institut Pasteur, Unité Limphopoïese, Inserm U668, Paris, France
    Eur J Immunol 42:1272-81. 2012
    ..Staining with anti-PLZF and anti-NK1.1 Abs allows the definition of two subsets of NKTαβ and NKTγδ thymocytes that differ phenotypically and ..
  92. pmc Treatment with a substance P receptor antagonist is neuroprotective in the intrastriatal 6-hydroxydopamine model of early Parkinson's disease
    Emma Thornton
    Adelaide Centre for Neuroscience Research, School of Medical Sciences, The University of Adelaide, Adelaide, South Australia
    PLoS ONE 7:e34138. 2012
    ..neuropeptide substance P (SP) is an important mediator of both neuroinflammation and BBB dysfunction through its NK1 receptor in a process known as neurogenic inflammation...
  93. ncbi Administration of macrophage colony-stimulating factor mobilized both CD11b+CD11c+ cells and NK1.1+ cells into peripheral blood
    Eriko Misawa
    Biochemical Research Laboratory, Morinaga Milk Industry Co Ltd, Higashihara 5 1 83, Zama, Kanagawa 228 8583, Japan
    Int Immunopharmacol 4:791-803. 2004
    ..On the other hand, the number of NK1.1+ cells was not changed by the 2-day treatment, but it was significantly increased by the 5-day treatment...
  94. pmc Heparin induces dimerization and confers proliferative activity onto the hepatocyte growth factor antagonists NK1 and NK2
    R H Schwall
    Genentech, Inc, South San Francisco, California 94080 4990, USA
    J Cell Biol 133:709-18. 1996
    ..Two truncated variants of HGF known as NK1 and NK2 have been reported to be competitive inhibitors of HGF binding to c-Met, and to function as HGF antagonists ..
  95. pmc Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists
    J C Beaujouan
    , INSERM U 114, Chaire de Neuropharmacologie, Paris
    Br J Pharmacol 108:793-800. 1993
    ..CP-C1)) and peptide (GR 71,251 and spantide) neurokinin1 (NK1) antagonists in mouse and rat preparations. 2...
  96. ncbi Tachykinins and tachykinin receptors in the gut, with special reference to NK2 receptors in human
    Alessandro Lecci
    Clinical Research Department, Menarini Ricerche, Via Sette Santi 1, 50131 Firenze, Italy
    Auton Neurosci 126:232-49. 2006
    ..The effects of SP, NKA and NKB are preferentially mediated through the stimulation of NK1, NK2 and NK3 receptors, respectively; however, the selectivity of natural TKs for their preferred receptors is ..
  97. ncbi P-Glycoprotein efflux reduces the brain concentration of the substance P (NK1 receptor) antagonists SR140333 and GR205171: a comparative study using mdr1a-/- and mdr1a+/+ mice
    N M J Rupniak
    Department of Pharmacology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex, UK
    Behav Pharmacol 14:457-63. 2003
    Investigation of the antidepressant-like actions of substance P (NK1 receptor) antagonists has been hindered by the few available compounds that bind with high affinity to the rat and mouse NK1 receptor, as these are the most commonly ..
  98. pmc Stringent V beta requirement for the development of NK1.1+ T cell receptor-alpha/beta+ cells in mouse liver
    T Ohteki
    Ludwig Institute for Cancer Research, University of Lausanne, Switzerland
    J Exp Med 183:1277-82. 1996
    ..major subset of CD4+8- and CD4-8- T cell receptor (TCR)-alpha/beta+ cells expressing the polymorphic natural killer NK1.1 surface marker. Liver NK1...
  99. ncbi The selective tachykinin neurokinin 1 (NK1) receptor antagonist, GR 205,171, stereospecifically inhibits light-induced phase advances of hamster circadian activity rhythms
    Robert L Gannon
    Department of Biology, Valdosta State University, Valdosta, GA 31698, USA
    Eur J Pharmacol 527:86-93. 2005
    ..a small collection of cells immunoreactive for substance P, the endogenous ligand of tachykinin neurokinin 1 (NK1) receptors...
  100. ncbi Pivotal role of endogenous tachykinins and the NK1 receptor in mediating leukocyte accumulation, in the absence of oedema formation, in response to TNFalpha in the cutaneous microvasculature
    Soraia K P Costa
    Centre for Cardiovascular Biology and Medicine, King s College, Guy s Campus London SE1, 1UL, UK
    J Neuroimmunol 171:99-109. 2006
    ..Cutaneous inflammatory models to characterize a TNFalpha-dependent mechanism where endogenous SP act via the NK1 receptor to promote leukocyte accumulation in the absence of oedema formation were used...
  101. ncbi Hepatocyte growth factor (HGF)/NK1 is a naturally occurring HGF/scatter factor variant with partial agonist/antagonist activity
    V Cioce
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 271:13110-5. 1996
    ..In this study, we describe a second naturally occurring HGF/SF variant, HGF/NK1, consisting of the HGF/SF amino-terminal sequence and first kringle domain...

Research Grants100

  1. PATHOGENESIS AND TREATMENT OF NERVE BLOCK INJURIES
    Robert Myers; Fiscal Year: 2002
    ..the sequence of events following nerve injury: (1) release of substance P (sP) at the injury site acts on NK1 receptors to induce production of tumor necrosis factor alpha (TNF) via modulation of a PKC signal transduction ..
  2. The Pharmacology of Spinal Analgesics
    Tony Yaksh; Fiscal Year: 2009
    ..Neurokinin 1 receptor (NK1) internalization and cFos/pCREB expression are robust tools to define in vivo the effect of acute and chronic ..
  3. Mechanisms of Immune Regulation in Mycobacterium Tuberculosis Infection
    Cheryl Day; Fiscal Year: 2009
    ....
  4. NEUROANATOMY AND MOLECULAR BIOLOGY OF AIRWAY NEURONS
    Richard D Dey; Fiscal Year: 2010
    ..that ozone exposure increases neurotrophin synthesis and release by airway epithelium and neurotrophin receptor and NK1 receptor expression in airway neurons;2) determine the direct effects of neurotrophins on cholinergic, iNANC and SP-..
  5. New Neural Targets for Opioid Use Disorders: Human Studies
    Sharon L Walsh; Fiscal Year: 2010
    ..Recent evidence suggests that inactivation of substance P receptors (NK1), either through genetic deletion or pharmacological blockade, significantly attenuates the rewarding effects of ..
  6. MACROPHAGE ACTIVATION & SUBSTANCE P RECEPTOR EXPRESSION
    KENNETH BOST; Fiscal Year: 2001
    ..The authors have demonstrated that macrophages express a receptor, relatively specific for substance P (NK1). Expression increases with activation...
  7. NEUROGENIC INFLAMMATORY RESPONSE TO RSV
    Giovanni Piedimonte; Fiscal Year: 2002
    ..found evidence that RSV causes strong upregulation of the gene coding for the high-affinity substance P receptor (NK1), which translates into a large increase in the number of these receptors expressed in the airway mucosa...
  8. Pharmacogenetics of ACE inhibitor-associated angioedema
    NANCY JOAN BROWN; Fiscal Year: 2010
    ..increased sensitivity to ACE inhibitor- induced peritracheal edema, an effect that is reversed by a substance P (NK1) receptor antagonist...
  9. Pharmacogenetics of ACE inhibitor-associated angioedema
    NANCY JOAN BROWN; Fiscal Year: 2011
    ..increased sensitivity to ACE inhibitor- induced peritracheal edema, an effect that is reversed by a substance P (NK1) receptor antagonist...
  10. LPS-PEPTIDE INTERACTION IN BLADDER INFLAMMATION
    Ricardo Saban; Fiscal Year: 2003
    ..Therefore, therapeutic interventions to control mast cell degranulation, PAR activation, NK1 receptors activity, or NF-kB will alter the outcome and severity of cystitis...
  11. Synaptic regulation of dorsal horn projection neurons
    AMY MACDERMOTT; Fiscal Year: 2007
    ..Because more than 80% of the lamina I and III projection neurons express receptor for substance P, called the NK1 receptor (NK1R), it has been possible to selectively ablate them and thus demonstrate their key role in expression ..
  12. Pharmacogenetics of ACE inhibitor-associated angioedema
    Nancy Brown; Fiscal Year: 2009
    ..of ACE inhibitor-associated angioedema in humans, by measuring the effect of specific bradykinin B2 and substance P NK1 receptor antagonists on the duration and severity of angioedema (SPECIFIC AIM 1)...
  13. Role of Medullary Substance P in Acute and Persistent Nociception
    Donna L Hammond; Fiscal Year: 2010
    ..and duration of SubP effects in the RVM of rats in the uninjured state, and confirm the role of neurokinin-1 (NK1) receptors...
  14. ORGIN AND DIFFERENTIATION OF NATURAL KILLER CELLS
    Vinay Kumar; Fiscal Year: 2003
    ..Flt3+ NK progenitors differentiate into IL-15 responsive NK precursors in vitro. These cells are NK1.1-, IL2/15Rbeta+...
  15. MOLECULAR MECHANISMS OF MHC LINKED SUSCEPTIBILITY
    Kai Wucherpfennig; Fiscal Year: 2001
    ..b>NK1.1+ T cells are of particular interest because they are the major source of IL-4 for the differentiation of naive T ..
  16. NEURAL REGULATION OF AIRWAYS DURING POSTNATAL MATURATION
    Richard Martin; Fiscal Year: 1999
    ..changes in tachykinin-mediated airway smooth muscle contraction, identify corresponding changes in tachykinin (NK1 and NK2) receptor function, localize these maturational changes between large airways and lung parenchyma, and ..
  17. MECHANISM OF BETA AMYLOID NEUROTOXICITY
    Bruce Yankner; Fiscal Year: 1993
    ..The mechanism of this effect will be initially examined by determining if it involves either the tachykinin NK1 receptor or the serpin receptor...
  18. Tachykinin regulation of anxiety and stress responses
    MARK HEATH; Fiscal Year: 2006
    ..We previously generated a line of mice that are lacking the gene for the neurokinin 1 (NK1) receptor, a protein that belongs to a family called the tachykinin receptors...
  19. CORTICOTROPIN RELEASING HORMONE INDUCED DURA MAST CELL A
    Theoharis Theoharides; Fiscal Year: 2001
    ..and dura vasodilation with or without pretreatment with the CRH receptor antagonist Astressin or the nonpeptide NK1-receptor antagonist SR 140...
  20. ULTRASTRUCTURE OF MESOLIMBIC TRANSMITTER INTERACTIONS
    Virginia M Pickel; Fiscal Year: 2010
    ..that are activated not only by glutamate, but also by aversion-associated peptides interacting with neurokinin-1 (NK1) receptors...
  21. Neurogenic Cardiac Damage and Sudden Death
    WILLIAM contact TALMAN; Fiscal Year: 2010
    ..the baroreflex in rats by selectively eliminating NTS (nucleus tractus solitarii) neurons that express the NK1 receptor leads to cardiac arrhythmias and sudden death...
  22. Neurogenic Cardiac Damage and Sudden Death
    WILLIAM TALMAN; Fiscal Year: 2009
    ..the baroreflex in rats by selectively eliminating NTS (nucleus tractus solitarii) neurons that express the NK1 receptor leads to cardiac arrhythmias and sudden death...
  23. NEUROANATOMY AND MOLECULAR BIOLOGY OF AIRWAY NEURONS
    RICHARD DEY; Fiscal Year: 2007
    ..that ozone exposure increases neurotrophin synthesis and release by airway epithelium and neurotrophin receptor and NK1 receptor expression in airway neurons; 2) determine the direct effects of neurotrophins on cholinergic, iNANC and ..
  24. NEUROANATOMY AND MOLECULAR BIOLOGY OF AIRWAY NEURONS
    RICHARD DEY; Fiscal Year: 2009
    ..that ozone exposure increases neurotrophin synthesis and release by airway epithelium and neurotrophin receptor and NK1 receptor expression in airway neurons; 2) determine the direct effects of neurotrophins on cholinergic, iNANC and ..
  25. MECHANISMS OF CANNABINOID'S ANTIEMETIC ACTIONS
    NISSAR DARMANI; Fiscal Year: 2007
    ..can potentiate the antivomiting efficacy of established antiemetics (serotonin 5-HT3-, dopamine D2- and neurokinin NK1-receptor antagonists and dexamethasone) against chemo- and radiotherapy-induced vomiting; 3) Determination of ..
  26. Nociceptive Mechanisms in Whiplash Injury
    Beth A Winkelstein; Fiscal Year: 2010
    ..In Aim 2 we use saporin conjugates in separate studies to selectively eliminate NK1 receptor-bearing and IB4-positive neurons in the facet joint and define their relative contributions to pain and ..
  27. ROLE OF THE LIMBIC-MIDBRAIN AXIS IN AGGRESSIVE BEHAVIOR
    Allan Siegel; Fiscal Year: 2003
    ..The objective of this grant application is to focus upon the role of substance P-neurokinin (NK1) receptors in the anterior medial hypothalamus...
  28. NEUROPEPTIDERGIC INHIBITION OF SPINAL PAIN TRANSMISSION
    Bradley K Taylor; Fiscal Year: 2010
    ..receptor coupling to G-proteins (Aim 2);the effect of injury on the inhibition by NPY of SP release and subsequent NK1 receptor (NK1) activation in the spinal cord (Aim 3A);and the effect of NPY on the activity of spinal neurons that ..
  29. VAGAL GASTRIC MOTOR CONTROL IN MICE
    ELITA PARTOSEOEDARSO; Fiscal Year: 2002
    ..The first hypothesis is that gastric relaxation is evoked by GABAb and NK1 receptors in neurons of the dorsal motor nucleus of the vagus (DMN) of mice...
  30. Mechanisms of Immune Regulation in Mycobacterium Tuberculosis Infection
    CHERYL LIANE DAY; Fiscal Year: 2010
    ....
  31. CALCITONIN GENE-RELATED PEPTIDE IN HYPERTENSION
    Gianfranco Alpini; Fiscal Year: 2006
    ..test this hypothesis, we will determine whether decreased CGRP or SP function (by studying CGRP KO and SP receptor (NK1) KO mice) alters the ability of the sensory nervous system to modulate BP in the absence or presence of ..