butyrylcholinesterase

Summary

Gene Symbol: butyrylcholinesterase
Description: butyrylcholinesterase
Alias: BCHED, CHE1, CHE2, cholinesterase, acylcholine acylhydrolase, butyrylcholine esterase, choline esterase II, cholinesterase (serum) 2, cholinesterase 1, pseudocholinesterase
Species: human
Products:     butyrylcholinesterase

Top Publications

  1. Arpagaus M, Kott M, Vatsis K, Bartels C, La Du B, Lockridge O. Structure of the gene for human butyrylcholinesterase. Evidence for a single copy. Biochemistry. 1990;29:124-31 pubmed
    We have isolated five genomic clones for human butyrylcholinesterase (BChE), using cDNA probes encoding the catalytic subunit of the hydrophilic tetramer [McTiernan et al. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 6682-6686]...
  2. Darvesh S, Kumar R, Roberts S, Walsh R, Martin E. Butyrylcholinesterase-Mediated enhancement of the enzymatic activity of trypsin. Cell Mol Neurobiol. 2001;21:285-96 pubmed
    1. Acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BuChE, EC 3.1.1.8) are enzymes that catalyze the hydrolysis of esters of choline. 2. Both AChE and BuChE have been shown to copurify with peptidases. 3...
  3. O Brien K, Saxby B, Ballard C, Grace J, Harrington F, Ford G, et al. Regulation of attention and response to therapy in dementia by butyrylcholinesterase. Pharmacogenetics. 2003;13:231-9 pubmed
    To determine the response of patients with different butyrylcholinesterase genotypes to therapy, and the influence of butyrylcholinesterase on cognition...
  4. Babaoglu M, Ocal T, Bayar B, Kayaalp S, Bozkurt A. Frequency and enzyme activity of the butyrylcholinesterase K-variant in a Turkish population. Eur J Clin Pharmacol. 2004;59:875-7 pubmed
    Among variants of the butyrylcholinesterase gene ( BChE), the K-variant causing Ala539Thr substitution is the most common one associated with about one-third reduction in the enzyme activity...
  5. Holmes C, Ballard C, Lehmann D, David Smith A, Beaumont H, Day I, et al. Rate of progression of cognitive decline in Alzheimer's disease: effect of butyrylcholinesterase K gene variation. J Neurol Neurosurg Psychiatry. 2005;76:640-3 pubmed
    To determine whether individuals with Alzheimer's disease (AD) and the K variant allele of butyrylcholinesterase have a slower rate of cognitive decline than those without the K variant allele of butyrylcholinesterase...
  6. Darvesh S, McDonald R, Darvesh K, Mataija D, Mothana S, Cook H, et al. On the active site for hydrolysis of aryl amides and choline esters by human cholinesterases. Bioorg Med Chem. 2006;14:4586-99 pubmed
    ..It has been speculated that the AAA activity, especially that of butyrylcholinesterase (BuChE), may be important in the development of the nervous system and in pathological processes such as ..
  7. Diamant S, Podoly E, Friedler A, Ligumsky H, Livnah O, Soreq H. Butyrylcholinesterase attenuates amyloid fibril formation in vitro. Proc Natl Acad Sci U S A. 2006;103:8628-33 pubmed
    In Alzheimer's disease, both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) colocalize with brain fibrils of amyloid-beta (Abeta) peptides, and synaptic AChE-S facilitates fibril formation by association with insoluble ..
  8. Lane R, Feldman H, Meyer J, He Y, Ferris S, Nordberg A, et al. Synergistic effect of apolipoprotein E epsilon4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease. Pharmacogenet Genomics. 2008;18:289-98 pubmed publisher
    To evaluate the synergistic effects of the apolipoprotein E (APOE) epsilon4 and butyrylcholinesterase K-variant (BCHE-K) alleles on progression to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI)...
  9. Darvesh S, Cash M, Reid G, Martin E, Mitnitski A, Geula C. Butyrylcholinesterase is associated with ?-amyloid plaques in the transgenic APPSWE/PSEN1dE9 mouse model of Alzheimer disease. J Neuropathol Exp Neurol. 2012;71:2-14 pubmed publisher
    Histochemical analysis of Alzheimer disease (AD) brain tissues indicates that butyrylcholinesterase (BuChE) is present in ?-amyloid (A?) plaques...

More Information

Publications105 found, 100 shown here

  1. Allderdice P, Gardner H, Galutira D, Lockridge O, LaDu B, McAlpine P. The cloned butyrylcholinesterase (BCHE) gene maps to a single chromosome site, 3q26. Genomics. 1991;11:452-4 pubmed
    Human tissues have two distinct cholinesterase activities: acetylcholinesterase and butyrylcholinesterase. Acetylcholinesterase functions in the transmission of nerve impulses, whereas the physiological function of butyryl-cholinesterase ..
  2. Ghebremedhin E, Thal D, Schultz C, Braak H. Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains. Neurosci Lett. 2002;320:25-8 pubmed
    The association between the K-variant of the butyrylcholinesterase gene (BCHE-K) and Alzheimer disease (AD) or AD-related neuropathology has been reported to date with conflicting results...
  3. Gätke M, Viby Mogensen J, Bundgaard J. Rapid simultaneous genotyping of the frequent butyrylcholinesterase variants Asp70Gly and Ala539Thr with fluorescent hybridization probes. Scand J Clin Lab Invest. 2002;62:375-83 pubmed
    The clinically important variants of butyrylcholinesterase (BChE) are the A- (Asp70Gly) and K-variants (Ala539Thr), which are common among Caucasians...
  4. Nicolet Y, Lockridge O, Masson P, Fontecilla Camps J, Nachon F. Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products. J Biol Chem. 2003;278:41141-7 pubmed
    ..two groups: acetylcholinesterase, involved in the hydrolysis of the neurotransmitter acetylcholine, and butyrylcholinesterase of unknown function...
  5. Huang Y, Huang Y, Baldassarre H, Wang B, Lazaris A, Leduc M, et al. Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning. Proc Natl Acad Sci U S A. 2007;104:13603-8 pubmed
    ..Because exposure to OP could create a danger for humans in the future, butyrylcholinesterase (BChE) has been developed for prophylaxis to these chemicals...
  6. Iwasaki T, Yoneda M, Nakajima A, Terauchi Y. Serum butyrylcholinesterase is strongly associated with adiposity, the serum lipid profile and insulin resistance. Intern Med. 2007;46:1633-9 pubmed
    We investigated the association between the serum butyrylcholinesterase (BChE) activity and parameters of adiposity, insulin resistance and the serum lipid profile, including the serum levels of triglyceride (TG), HDL-cholesterol (HDL-C) ..
  7. Li H, Schopfer L, Masson P, Lockridge O. Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramers. Biochem J. 2008;411:425-32 pubmed publisher
    BChE (butyrylcholinesterase) protects the cholinergic nervous system from organophosphorus nerve agents by scavenging these toxins...
  8. Podoly E, Bruck T, Diamant S, Melamed Book N, Weiss A, Huang Y, et al. Human recombinant butyrylcholinesterase purified from the milk of transgenic goats interacts with beta-amyloid fibrils and suppresses their formation in vitro. Neurodegener Dis. 2008;5:232-6 pubmed publisher
    In Alzheimer's disease (AD), brain butyrylcholinesterase (BChE) co-localizes with beta-amyloid (Abeta) fibrils. In vitro testing of the significance of this phenomenon to AD progress...
  9. Tasker A, Ballard C, Joachim C, Warden D, Okello E, Perry R, et al. Butyrylcholinesterase K variant associated with higher enzyme activity in the temporal cortex of elderly patients. Neurosci Lett. 2008;442:297-9 pubmed publisher
    There is evidence to suggest an involvement of the K variant of the butyrylcholinesterase gene (BCHE) in dementia. We have examined the relationship between BCHE genotype and butyrylcholinesterase (BuChE) activity in autopsy brain tissue...
  10. Maetzler W, Keller S, Michelis J, Koehler N, Stransky E, Becker C, et al. No differences of butyrylcholinesterase protein activity and allele frequency in Lewy body diseases. Neurobiol Dis. 2009;35:296-301 pubmed publisher
    b>Butyrylcholinesterase (BChE) genotypes and protein (BuChE) activity, especially in combination with Apolipoprotein E4 (ApoE4), have been investigated as risk factors for developing Alzheimer disease (AD) and may be associated with the ..
  11. Darreh Shori T, Modiri N, Blennow K, Baza S, Kamil C, Ahmed H, et al. The apolipoprotein E ?4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase. Neurobiol Aging. 2011;32:1236-48 pubmed publisher
    ..Certain butyrylcholinesterase (BuChE) polymorphisms together with the ApoE ?4 allele synergistically increase the risk of AD...
  12. Darreh Shori T, Forsberg A, Modiri N, Andreasen N, Blennow K, Kamil C, et al. Differential levels of apolipoprotein E and butyrylcholinesterase show strong association with pathological signs of Alzheimer's disease in the brain in vivo. Neurobiol Aging. 2011;32:2320.e15-32 pubmed publisher
    ..E (ApoE) ?4, and female gender, are associated with differential levels of ApoE proteins and butyrylcholinesterase (BuChE) in the cerebrospinal fluid (CSF) of AD patients...
  13. Benyamin B, Middelberg R, Lind P, Valle A, Gordon S, Nyholt D, et al. GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors. Hum Mol Genet. 2011;20:4504-14 pubmed publisher
    Serum butyrylcholinesterase (BCHE) activity is associated with obesity, blood pressure and biomarkers of cardiovascular and diabetes risk...
  14. Esmaeilnejad B, Tavassoli M, Samiei A, Hajipour N, Imani Baran A, Farhang Pajuh F. Evaluation of oxidative stress and antioxidant status, serum trace mineral levels and cholinesterases activity in cattle infected with Anaplasma marginale. Microb Pathog. 2018;123:402-409 pubmed publisher
    ..and serum concentrations of antioxidant trace minerals (copper, iron, zinc, manganese, and selenium) and butyrylcholinesterase (BChE) were determined...
  15. Hagstrom D, Hirokawa H, Zhang L, Radic Z, Taylor P, Collins E. Planarian cholinesterase: in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation. Arch Toxicol. 2017;91:2837-2847 pubmed publisher
    ..catalysis, it is unknown whether this is accomplished through an acetylcholinesterase (AChE), butyrylcholinesterase (BChE), or a hybrid esterase and how OP exposure affects esterase activity...
  16. Wilhelm C, Snider T, Babin M, Jett D, Platoff G, Yeung D. A comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides. Toxicol Appl Pharmacol. 2014;281:254-65 pubmed publisher
    ..Clinical signs of toxicity were observed for 24 h post challenge and blood cholinesterase [AChE and butyrylcholinesterase (BChE)] activity was analyzed utilizing a modified Ellman's method...
  17. Kopjar N, Zunec S, Mendaš G, Micek V, Kasuba V, Mikolić A, et al. Evaluation of chlorpyrifos toxicity through a 28-day study: Cholinesterase activity, oxidative stress responses, parent compound/metabolite levels, and primary DNA damage in blood and brain tissue of adult male Wistar rats. Chem Biol Interact. 2018;279:51-63 pubmed publisher
    ..day. Following treatment, total cholinesterase activity and activities of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were measured...
  18. Schmidt E, Tvarijonaviciute A, Martinez Subiela S, Ceron J, Eckersall P. Changes in biochemical analytes in female dogs with subclinical Ancylostoma spp. infection. BMC Vet Res. 2016;12:203 pubmed publisher
    ..LDL); the serum iron profile: iron, unsaturated iron binding-capacity (UIBC), and ferritin; the enzyme butyrylcholinesterase (BChe); the pancreatic profile: amylase, lipase, and trypsin-like immunoreactivity (TLI); the oxidative ..
  19. Busić V, Katalinić M, Sinko G, Kovarik Z, Gaso Sokac D. Pyridoxal oxime derivative potency to reactivate cholinesterases inhibited by organophosphorus compounds. Toxicol Lett. 2016;262:114-122 pubmed publisher
    ..by a novel synthetic pathway, to reactivate recombinant human AChE and the related purified human plasma butyrylcholinesterase (BChE, EC 3.1.1.8) inhibited by VX, tabun and paraoxon...
  20. Moniruzzaman M, Asaduzzaman M, Hossain M, Sarker J, Rahman S, Rashid M, et al. In vitro antioxidant and cholinesterase inhibitory activities of methanolic fruit extract of Phyllanthus acidus. BMC Complement Altern Med. 2015;15:403 pubmed publisher
    ..67 μg/ml. The MEPA exhibited inhibition of rat brain acetylcholinesterase and human blood butyrylcholinesterase in a dose dependent manner and the IC50 value was found to be 1009.87 μg/ml and 449...
  21. Cortes N, Sierra K, Alzate F, Osorio E, Osorio E. Alkaloids of Amaryllidaceae as Inhibitors of Cholinesterases (AChEs and BChEs): An Integrated Bioguided Study. Phytochem Anal. 2018;29:217-227 pubmed publisher
    ..However, butyrylcholinesterase (BChE), contributes critically to cholinergic dysfunction associated with AD...
  22. Topcagic A, Ćavar Zeljković S, Karalija E, Galijasevic S, Sofic E. Evaluation of phenolic profile, enzyme inhibitory and antimicrobial activities of Nigella sativa L. seed extracts. Bosn J Basic Med Sci. 2017;17:286-294 pubmed publisher
    ..sativa methanol, n-hexane, and aqueous seed extracts for their inhibitory activity against butyrylcholinesterase (BChE) and catalase (CAT) as well as for antimicrobial activity against several bacterial and a yeast ..
  23. Cunha A, Felippe I, Ferreira Junior N, Resstel L, Guimarães D, Beijamini V, et al. Neuroreflex control of cardiovascular function is impaired after acute poisoning with chlorpyrifos, an organophosphorus insecticide: Possible short and long term clinical implications. Toxicology. 2018;398-399:13-22 pubmed publisher
    ..Blood samples were taken for measurements of butyrylcholinesterase (BChE) activity while acetylcholinesterase (AChE) activity was measured in brainstem samples...
  24. Maurice T, Strehaiano M, Siméon N, Bertrand C, Chatonnet A. Learning performances and vulnerability to amyloid toxicity in the butyrylcholinesterase knockout mouse. Behav Brain Res. 2016;296:351-360 pubmed publisher
    b>Butyrylcholinesterase (BChE) is an important enzyme for detoxication and metabolism of ester compounds...
  25. Narváez C, Ríos J, Píriz G, Sanchez Hernandez J, Sabat P. Subchronic exposure to chlorpyrifos affects energy expenditure and detoxification capacity in juvenile Japanese quails. Chemosphere. 2016;144:775-84 pubmed publisher
    ..Carboxylesterase (CbE), butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) activities were periodically measured in multiple tissues along ..
  26. Schopfer L, Delacour H, Masson P, Leroy J, Krejci E, Lockridge O. The C5 Variant of the Butyrylcholinesterase Tetramer Includes a Noncovalently Bound 60 kDa Lamellipodin Fragment. Molecules. 2017;22: pubmed publisher
    Humans with the C5 genetic variant of butyrylcholinesterase (BChE) have 30-200% higher plasma BChE activity, low body weight, and shorter duration of action of the muscle relaxant succinylcholine...
  27. Jaguezeski A, Perin G, Rhoden L, da Silva T, Mendes R, Bottari N, et al. Changes on the activity of cholinesterase's in an immunomodulatory response of cattle infected by Listeria monocytogenes. Microb Pathog. 2018;114:36-40 pubmed publisher
    ..and 14 post-infection (PI) to evaluate the activity of acetylcholinesterase (AChE) in the blood, and seric butyrylcholinesterase (BChE) activity, as well as total protein, albumin, globulin and C-reactive protein (CPR) levels in serum...
  28. Sharma G, Khatri I, Subramanian S. Comparative Genomics of Myxobacterial Chemosensory Systems. J Bacteriol. 2018;200: pubmed publisher
    ..and six novel CSS ("extra CSS" [ECSS]) were thus identified in the myxobacteria besides the previously reported Che1 to Che8 systems from M...
  29. Muñoz Delgado E, Montenegro M, Campoy F, Moral Naranjo M, Cabezas Herrera J, Kovacs G, et al. Expression of cholinesterases in human kidney and its variation in renal cell carcinoma types. FEBS J. 2010;277:4519-29 pubmed publisher
    ..49 mU·mg(-1), P = 0.047) with respect to their controls (1.52 ± 0.92 and 1.57 ± 0.44 mU·mg(-1)). Butyrylcholinesterase activity increased in pRCC (5.12 ± 2.61 versus 2.73 ± 1.15 mU·mg(-1), P = 0.031)...
  30. Macdonald I, Martin E, Rosenberry T, Darvesh S. Probing the peripheral site of human butyrylcholinesterase. Biochemistry. 2012;51:7046-53 pubmed
    Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) catalyze the hydrolysis of the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission...
  31. Perez J, Pantazides B, Watson C, Thomas J, Blake T, Johnson R. Enhanced stability of blood matrices using a dried sample spot assay to measure human butyrylcholinesterase activity and nerve agent adducts. Anal Chem. 2015;87:5723-9 pubmed publisher
    ..In this work, we introduce a dried spot activity assay for quantifying butyrylcholinesterase (BChE) specific activity which is BChE activity normalized to the total protein content in a sample spot...
  32. Lushchekina S, Nemukhin A, Varfolomeev S, Masson P. Understanding the non-catalytic behavior of human butyrylcholinesterase silent variants: Comparison of wild-type enzyme, catalytically active Ala328Cys mutant, and silent Ala328Asp variant. Chem Biol Interact. 2016;259:223-232 pubmed publisher
    Conformational dynamics of wild-type human butyrylcholinesterase (BChE), two mutants of residue Ala328, the catalytically active Ala328Cys, and the catalytically inactive (silent) Ala328Asp, and their interactions with butyrylcholine ..
  33. Strelnik A, Petukhov A, Zueva I, Zobov V, Petrov K, Nikolsky E, et al. Novel potent pyridoxine-based inhibitors of AChE and BChE, structural analogs of pyridostigmine, with improved in vivo safety profile. Bioorg Med Chem Lett. 2016;26:4092-4 pubmed publisher
    ..3 and 0.51mg/kg, respectively). The obtained results pave the way to design of novel potent and safe cholinesterase inhibitors for symptomatic treatment of neuromuscular disorders.
  34. Chen V, Gao Y, Geng L, Brimijoin S. Butyrylcholinesterase gene transfer in obese mice prevents postdieting body weight rebound by suppressing ghrelin signaling. Proc Natl Acad Sci U S A. 2017;114:10960-10965 pubmed publisher
    ..Here we applied viral gene transfer of the acyl-ghrelin hydrolyzing enzyme, butyrylcholinesterase (BChE), in a mouse model of diet-induced obesity...
  35. Darvesh S, Hopkins D. Differential distribution of butyrylcholinesterase and acetylcholinesterase in the human thalamus. J Comp Neurol. 2003;463:25-43 pubmed
    It has been hypothesized that acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) are coregulators of the duration of action of acetylcholine in cholinergic neurotransmission, suggesting that BuChE may also have an important ..
  36. Manoharan I, Kuznetsova A, Fisk J, Boopathy R, Lockridge O, Darvesh S. Comparison of cognitive functions between people with silent and wild-type butyrylcholinesterase. J Neural Transm (Vienna). 2007;114:939-45 pubmed
    In the human brain, butyrylcholinesterase (BuChE) is expressed in neurons and glia. For example, many nuclei in the human thalamus, with projections to the cerebral cortex, contain a large number of neurons with intense BuChE activity...
  37. Bernardi C, Ribeiro E, Cavalli I, Chautard Freire Maia E, Souza R. Amplification and deletion of the ACHE and BCHE cholinesterase genes in sporadic breast cancer. Cancer Genet Cytogenet. 2010;197:158-65 pubmed publisher
    Increasing evidence supports the involvement of acetylcholinesterase and butyrylcholinesterase in cell proliferation control and differentiation, reinforcing the hypothesis that these enzymes might have an influence in tumorigenesis...
  38. Wandhammer M, de Koning M, van Grol M, Loiodice M, Saurel L, Noort D, et al. A step toward the reactivation of aged cholinesterases--crystal structure of ligands binding to aged human butyrylcholinesterase. Chem Biol Interact. 2013;203:19-23 pubmed publisher
    ..molecules were synthesized and the crystal structures of the complexes they form with soman-aged human butyrylcholinesterase were solved...
  39. Hashim Y, Shepherd D, Wiltshire S, Holman R, Levy J, Clark A, et al. Butyrylcholinesterase K variant on chromosome 3 q is associated with Type II diabetes in white Caucasian subjects. Diabetologia. 2001;44:2227-30 pubmed
    To determine the association of three genes associated with Alzheimer's disease--butyrylcholinesterase (BcHE) on chromosome 3 q, alpha2 macroglobulin (alpha2M) on chromosome 12 p and apolipoprotein E (ApoE) on chromosome 19 q--with Type ..
  40. Munshaw S, Hwang H, Torbenson M, Quinn J, Hansen K, Astemborski J, et al. Laser captured hepatocytes show association of butyrylcholinesterase gene loss and fibrosis progression in hepatitis C-infected drug users. Hepatology. 2012;56:544-54 pubmed publisher
    ..precirrhosis fibrosis were depleted for genes involved in small molecule and drug metabolism, especially butyrylcholinesterase (BCHE), a gene involved in the metabolism of drugs of abuse...
  41. Aeinehband S, Lindblom R, Al Nimer F, Vijayaraghavan S, Sandholm K, Khademi M, et al. Complement component C3 and butyrylcholinesterase activity are associated with neurodegeneration and clinical disability in multiple sclerosis. PLoS ONE. 2015;10:e0122048 pubmed publisher
    ..profiling and linkage analysis we found co-regulation of complement C3 immediately downstream of butyrylcholinesterase (BuChE), an enzyme hydrolyzing acetylcholine (ACh), a classical neurotransmitter with immunoregulatory ..
  42. Naksen W, Prapamontol T, Mangklabruks A, Chantara S, Thavornyutikarn P, Srinual N, et al. Associations of maternal organophosphate pesticide exposure and PON1 activity with birth outcomes in SAWASDEE birth cohort, Thailand. Environ Res. 2015;142:288-96 pubmed publisher
    ..Maternal AChE, butyrylcholinesterase (BChE) and PON1 activities were measured three times during pregnancy and urinary DAP concentrations were ..
  43. Costa M, Bernardi J, Fiuza T, Costa L, Brandão R, Pereira M. N-acetylcysteine protects memory decline induced by streptozotocin in mice. Chem Biol Interact. 2016;253:10-7 pubmed publisher
    ..On the tenth day animals were euthanized for AChE and butyrylcholinesterase (BChE) activities and ACh, energy-rich phosphate and brain glucose uptake levels evaluations...
  44. Hester K, Liu J, Flynn N, Sultatos L, Geng L, Brimijoin S, et al. Polyionic complexes of butyrylcholinesterase and poly-l-lysine-g-poly(ethylene glycol): Comparative kinetics of catalysis and inhibition and in vitro inactivation by proteases and heat. Chem Biol Interact. 2017;275:86-94 pubmed publisher
    We previously reported that recombinant human butyrylcholinesterase (rhBChE) complexed with a series of copolymers of poly-l-lysine (PLL) with grafted (polyethylene) glycol (PEG) (i.e...
  45. Khan S, Khan S, Shah Z, Asiri A. Withanolides: Biologically Active Constituents in the Treatment of Alzheimer's Disease. Med Chem. 2016;12:238-56 pubmed
    ..ChEI) are chemicals which inhibit the splitting of cholinesterase enzymes (acetylcholinesterase and butyrylcholinesterase)...
  46. Jasiecki J, Jońca J, Żuk M, Szczoczarz A, Janaszak Jasiecka A, Lewandowski K, et al. Activity and polymorphisms of butyrylcholinesterase in a Polish population. Chem Biol Interact. 2016;259:70-77 pubmed publisher
    b>Butyrylcholinesterase (BChE) activity assay and inhibitor phenotyping can help to identify individuals at risk of prolonged paralysis following the administration of neuromuscular blocking agents, like succinylcholine, pesticides and ..
  47. Pytel E, Bukowska B, Koter Michalak M, Olszewska Banaszczyk M, Gorzelak Pabis P, Broncel M. Effect of intensive lipid-lowering therapies on cholinesterase activity in patients with coronary artery disease. Pharmacol Rep. 2017;69:150-155 pubmed publisher
    ..The present study attempts to determine how statin or combined statin and ezetimibe therapy influences cholinesterase activity...
  48. Sykam A, Gutlapalli V, Tenali S, Meena A, Chandran P, Suneetha S, et al. Anticeramide antibody and butyrylcholinesterase in peripheral neuropathies. J Clin Neurosci. 2017;42:204-208 pubmed publisher
    ..b>Butyrylcholinesterase (BChE) is a multifunctional enzyme, its involvement in neurodegenerative diseases has been well ..
  49. Zivkovic A, Tourelle K, Brenner T, Weigand M, Hofer S, Schmidt K. Reduced serum cholinesterase activity indicates splenic modulation of the sterile inflammation. J Surg Res. 2017;220:275-283 pubmed publisher
    ..Serum cholinesterase (butyrylcholinesterase [BChE]) is an enzyme that hydrolyzes acetylcholine...
  50. Mateo I, Llorca J, Infante J, Rodriguez Rodriguez E, Berciano J, Combarros O. Gene-gene interaction between 14-3-3 zeta and butyrylcholinesterase modulates Alzheimer's disease risk. Eur J Neurol. 2008;15:219-22 pubmed publisher
    ..14-3-3 zeta protein and butyrylcholinesterase (BCHE) are associated with NFT in AD brain and stimulate tau phosphorylation...
  51. Shahmohamadnejad S, Vaisi raygani A, Shakiba Y, Kiani A, Rahimi Z, Bahrehmand F, et al. Association between butyrylcholinesterase activity and phenotypes, paraoxonase192 rs662 gene polymorphism and their enzymatic activity with severity of rheumatoid arthritis: correlation with systemic inflammatory markers and oxidative stress, prelimi. Clin Biochem. 2015;48:63-9 pubmed publisher
    ..The two major bioscavenger enzymes that are associated with inflammation and oxidative stress are human-butyrylcholinesterase (BuChE) and paraoxonase-1 (PON-1)...
  52. Pohanka M. Photography by Cameras Integrated in Smartphones as a Tool for Analytical Chemistry Represented by an Butyrylcholinesterase Activity Assay. Sensors (Basel). 2015;15:13752-62 pubmed publisher
    ..e., the determination of a biochemical marker butyrylcholinesterase (BChE). The work should demonstrate suitability of a smartphone-integrated camera for analytical purposes...
  53. Å iÅ¡ková K, Dubničková M, PaÅ¡ková Ä, Rajdl D, ÄŽuračková Z, Muchová J, et al. Betaine increases the butyrylcholinesterase activity in rat plasma. Physiol Res. 2016;65:101-8 pubmed
    The physiological function of butyrylcholinesterase (EC 3.1.1...
  54. Choi R, Roy A, Jung H, Ali M, Min B, Park C, et al. BACE1 molecular docking and anti-Alzheimer's disease activities of ginsenosides. J Ethnopharmacol. 2016;190:219-30 pubmed publisher
    ..In vitro cholinesterase enzyme assays by using acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and BACE1 were performed...
  55. Chen G, Canniffe D, Hunter C. Three classes of oxygen-dependent cyclase involved in chlorophyll and bacteriochlorophyll biosynthesis. Proc Natl Acad Sci U S A. 2017;114:6280-6285 pubmed publisher
    ..These data delineate three classes of O2-dependent cyclase in chlorophototrophic organisms from higher plants to bacteria, and their evolution is discussed herein. ..
  56. Scotti L, Scotti M. Computer Aided Drug Design Studies in the Discovery of Secondary Metabolites Targeted Against Age-Related Neurodegenerative Diseases. Curr Top Med Chem. 2015;15:2239-52 pubmed
    ..1.1.7, butyrylcholinesterase (BChE; EC 3.1.1.8, and monoamine oxidase (MAO; EC 1.4.3.4...
  57. Eiberg H, Nielsen L, Klausen J, Dahlen M, Kristensen M, Bisgaard M, et al. Linkage between serum cholinesterase 2 (CHE2) and gamma-crystallin gene cluster (CRYG): assignment to chromosome 2. Clin Genet. 1989;35:313-21 pubmed
    Serum cholinesterase 2 (CHE2) was examined in a Danish material of normal families that has been tested earlier for 70-78 classical marker systems and 25 RFLP systems...
  58. Masson P, Goldstein B, Debouzy J, Froment M, Lockridge O, Schopfer L. Damped oscillatory hysteretic behaviour of butyrylcholinesterase with benzoylcholine as substrate. Eur J Biochem. 2004;271:220-34 pubmed
    ..kinetics for the hydrolysis of benzoylcholine (BzCh) and benzoylthiocholine (BzSCh) by wild-type human butyrylcholinesterase (BuChE) and by the peripheral anionic site mutant D70G were compared...
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    ..However, the supply of the native human proteins is either limited (e.g., plasma-derived butyrylcholinesterase and erythrocytic acetylcholinesterase) or nonexisting (synaptic acetylcholinesterase)...
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    Human serum cholinesterase was digested with pepsin under conditions which left disulfide bonds intact. Peptides were isolated by high pressure liquid chromatography, and those containing disulfide bonds were identified by a color assay...
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    Two kilobase segments of the 5'-untranslated regions of the human and rabbit butyrylcholinesterase (BCHE) genes were characterized...
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    The common K variant of butyrylcholinesterase (BChE-K), an enzyme which metabolizes acetylcholine and organophosphates, has been associated with Alzheimer's disease, especially in the presence of the apolipoprotein E epsilon 4 allele (..
  73. Suarez D, Field M. Molecular dynamics simulations of human butyrylcholinesterase. Proteins. 2005;59:104-17 pubmed
    Herein, we present results from molecular dynamics (MD) simulations of the human butyrylcholinesterase (BuChE) enzyme in aqueous solution...
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    Mivacurium is hydrolyzed by the butyrylcholinesterase enzyme, and patients with hereditary changes of the enzyme often have prolonged duration of action of mivacurium...
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    ..enzyme-substrate complex, transition states, intermediates, and product involved in the process of human butyrylcholinesterase (BChE)-catalyzed hydrolysis of (-)-cocaine...
  76. Vaisi Raygani A, Rahimi Z, Entezami H, Kharrazi H, Bahrhemand F, Tavilani H, et al. Butyrylcholinesterase K variants increase the risk of coronary artery disease in the population of western Iran. Scand J Clin Lab Invest. 2008;68:123-9 pubmed
    The conflicting results of several studies suggest that there is an association between the butyrylcholinesterase-K variant (BCHE-K, G1615A/Ala539Thr) and the risk of developing coronary artery disease (CAD) in diabetes and non-diabetic ..
  77. Grigoryan H, Halebyan G, Lefebvre B, Brasme B, Masson P. Mechanism of hydrolysis of dicholine esters with long polymethylene chain by human butyrylcholinesterase. Biochim Biophys Acta. 2008;1784:1818-24 pubmed publisher
    Human butyrylcholinesterase hydrolyzes long chain dicholine esters more rapidly than short chain dicholine esters...
  78. Wandhammer M, Carletti E, van der Schans M, Gillon E, Nicolet Y, Masson P, et al. Structural study of the complex stereoselectivity of human butyrylcholinesterase for the neurotoxic V-agents. J Biol Chem. 2011;286:16783-9 pubmed publisher
    ..Human butyrylcholinesterase (BChE) functions as a bioscavenger, protecting the cholinergic system against OPs...
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    b>Butyrylcholinesterase (BChE) and acetylcholinesterase (AchE) are two enzymes of the cholinergic system putatively involved in coronary artery disease (CAD)...
  80. Pottie I, Higgins E, Blackman R, Macdonald I, Martin E, Darvesh S. Cysteine thioesters as myelin proteolipid protein analogues to examine the role of butyrylcholinesterase in myelin decompaction. ACS Chem Neurosci. 2011;2:151-9 pubmed publisher
    ..Recent studies have indicated that active MS lesions express elevated levels of butyrylcholinesterase (BuChE). BuChE can hydrolyze a wide variety of esters, including fatty acid esters of protein...
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    ..1 deletion in one of the patients. Candidate genes at this locus include the acetylcholine-metabolizing butyrylcholinesterase (BCHE) expressing gene (OMIM #177400), which is of particular interest...
  82. Graham L, Johnson D, Carter M, Stout E, Erol H, Isenberg S, et al. A high-throughput UHPLC-MS/MS method for the quantification of five aged butyrylcholinesterase biomarkers from human exposure to organophosphorus nerve agents. Biomed Chromatogr. 2017;31: pubmed publisher
    ..In the body, OPNAs bind to butyrylcholinesterase (BChE) to form nerve agent adducts (OPNA-BChE)...
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    ..to determine their ability to inhibit the enzymes acetylcholinesterase (AChE, from electric eel) and butyrylcholinesterase (BChE, from equine serum)...
  84. Manyilizu W, Mdegela R, Kazwala R, Nonga H, Muller M, Lie E, et al. Association of Long-Term Pesticide Exposure and Biologic Parameters in Female Farm Workers in Tanzania: A Cross Sectional Study. Toxics. 2016;4: pubmed publisher
    ..4, 95% CI: 0.3-0.5; ? = 0.7, 95% CI: 0.6-0.9, respectively). Long-term pesticide exposure affects the hemato-biochemical and esterase responses, establishing the need for further studies. ..
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    ..In this review, the role of phenolic acids as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is discussed, including the structure-activity relationship...
  86. Rivas Hernández G, May Uc Y, Noreña Barroso E, Cobos Gasca V, Rodriguez Fuentes G. Plasma Cholinesterase Activity in Female Green Turtles Chelonia mydas Nesting in Laguna de Terminos, Mexico Related to Organochlorine Pesticides in Their Eggs. Bull Environ Contam Toxicol. 2018;100:101-105 pubmed publisher
    The inhibition of cholinesterase (ChE) activity has been used as a biomarker of exposure to organophosphate and carbamate insecticides...
  87. Combarros O, Riancho J, Arozamena J, Mateo I, Llorca J, Infante J, et al. Interaction between estrogen receptor-alpha and butyrylcholinesterase genes modulates Alzheimer's disease risk. J Neurol. 2007;254:1290-2 pubmed
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    Variations in the butyrylcholinesterase (BCHE) gene can prolong neuromuscular block after the administration of the neuromuscular blocking drugs succinylcholine and mivacurium...
  89. Furtado Alle L, Andrade F, Nunes K, Mikami L, Souza R, Chautard Freire Maia E. Association of variants of the -116 site of the butyrylcholinesterase BCHE gene to enzyme activity and body mass index. Chem Biol Interact. 2008;175:115-8 pubmed publisher
    b>Butyrylcholinesterase (BChE) is coded by the BCHE gene that presents four exons...
  90. Patterson C, Todd S, Passmore A. Effect of apolipoprotein E and butyrylcholinesterase genotypes on cognitive response to cholinesterase inhibitor treatment at different stages of Alzheimer's disease. Pharmacogenomics J. 2011;11:444-50 pubmed publisher
    ..We report an analysis of genetic factors affecting response to cholinesterase inhibitor therapy in 165 subjects with Alzheimer's disease (AD)...
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    ..Human butyrylcholinesterase (BuChE) and paraoxonase-1 (PON1) are two major bioscavenger enzymes that are associated with inflammation, ..
  92. Gok M, Zeybek N, Bodur E. Butyrylcholinesterase expression is regulated by fatty acids in HepG2 cells. Chem Biol Interact. 2016;259:276-281 pubmed publisher
    b>Butyrylcholinesterase (BChE) is mostly associated with the detoxification of xenobiotics...