BST2

Summary

Gene Symbol: BST2
Description: bone marrow stromal cell antigen 2
Alias: CD317, TETHERIN, BST-2, HM1.24 antigen, NPC-A-7, bone marrow stromal antigen 2
Species: human

Top Publications

  1. doi Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu
    Stuart J D Neil
    Aaron Diamond AIDS Research Center and Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, New York 10016, USA
    Nature 451:425-30. 2008
  2. pmc The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein
    Nanette Van Damme
    The San Diego Department of Veterans Affairs Healthcare System, San Diego, CA 92161, USA
    Cell Host Microbe 3:245-52. 2008
  3. pmc Tetherin inhibits HIV-1 release by directly tethering virions to cells
    David Perez-Caballero
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    Cell 139:499-511. 2009
  4. pmc Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism
    Janet L Douglas
    Oregon Health and Science University, Vaccine and Gene Therapy Institute, Beaverton, 97006, USA
    J Virol 83:7931-47. 2009
  5. pmc Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking
    Richard S Mitchell
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    PLoS Pathog 5:e1000450. 2009
  6. pmc Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains
    Daniel Sauter
    Institute of Molecular Virology, Universitatsklinikum, 89081 Ulm, Germany
    Cell Host Microbe 6:409-21. 2009
  7. doi HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factor
    Christine Goffinet
    Department of Virology, University of Heidelberg, Heidelberg, Germany
    Cell Host Microbe 5:285-97. 2009
  8. pmc Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirus
    Mandana Mansouri
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Virol 83:9672-81. 2009
  9. pmc HIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomes
    Yukie Iwabu
    Department of Pathology, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    J Biol Chem 284:35060-72. 2009
  10. pmc HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation
    Bastien Mangeat
    Department of Dermatology and Venereology, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland
    PLoS Pathog 5:e1000574. 2009

Research Grants

  1. Role of VPU in Retroviral Particle Assembly
    Paul W Spearman; Fiscal Year: 2011
  2. Interactions of Ebola virus glycoproteins with host cells
    PAUL F BATES; Fiscal Year: 2010
  3. Immune evasion by gamma 2 Herpesviruses
    KLAUS J FRUEH; Fiscal Year: 2010
  4. HIV-1 Vpu and BST-2/CD317
    John Guatelli; Fiscal Year: 2009
  5. PERIPHERAL NEUROPATHY IN LENTIVIRUS INFECTIONS: EARLY VIRAL AND HOST DETERMINANTS
    Christopher Power; Fiscal Year: 2010
  6. LENTIVIRUS-INDUCED NEUROPATHY: VIRAL DIVERSITY AND HOST*
    Christopher Power; Fiscal Year: 2004
  7. NEUROTOXIC MECHANISMS MEDIATED BY LENTIVIRUS-INDUCED PROTEOLYSIS
    Christopher Power; Fiscal Year: 2007
  8. Human Endogenous Retroelements in HIV Immunopathogenesis
    Douglas F Nixon; Fiscal Year: 2010
  9. T Regulatory Cells in HIV Infection
    Douglas F Nixon; Fiscal Year: 2010
  10. DRUG ABUSE, SUBSTANCE P AND HIV
    Wenzhe Ho; Fiscal Year: 2007

Detail Information

Publications145 found, 100 shown here

  1. doi Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu
    Stuart J D Neil
    Aaron Diamond AIDS Research Center and Laboratory of Retrovirology, The Rockefeller University, 455 First Avenue, New York, New York 10016, USA
    Nature 451:425-30. 2008
    ..24), a membrane protein of previously unknown function, as a tetherin. Specifically, CD317 expression correlated with, and induced, a requirement for Vpu during HIV-1 and murine ..
  2. pmc The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein
    Nanette Van Damme
    The San Diego Department of Veterans Affairs Healthcare System, San Diego, CA 92161, USA
    Cell Host Microbe 3:245-52. 2008
    ..Here we show that the interferon-induced cellular protein BST-2/HM1.24/CD317 is such a factor...
  3. pmc Tetherin inhibits HIV-1 release by directly tethering virions to cells
    David Perez-Caballero
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    Cell 139:499-511. 2009
    b>Tetherin is an interferon-induced protein whose expression blocks the release of HIV-1 and other enveloped viral particles...
  4. pmc Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism
    Janet L Douglas
    Oregon Health and Science University, Vaccine and Gene Therapy Institute, Beaverton, 97006, USA
    J Virol 83:7931-47. 2009
    ..Recently, BST-2 has been identified as the interferon-inducible cellular factor Tetherin, which restricts HIV virion release in the absence of Vpu...
  5. pmc Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking
    Richard S Mitchell
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    PLoS Pathog 5:e1000450. 2009
    The interferon-induced transmembrane protein BST-2/CD317 (tetherin) restricts the release of diverse enveloped viruses from infected cells...
  6. pmc Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains
    Daniel Sauter
    Institute of Molecular Virology, Universitatsklinikum, 89081 Ulm, Germany
    Cell Host Microbe 6:409-21. 2009
    Vpu proteins of pandemic HIV-1 M strains degrade the viral receptor CD4 and antagonize human tetherin to promote viral release and replication...
  7. doi HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factor
    Christine Goffinet
    Department of Virology, University of Heidelberg, Heidelberg, Germany
    Cell Host Microbe 5:285-97. 2009
    ..Human CD317 (BST-2/HM1.24/tetherin) is a restriction factor that blocks release of human immunodeficiency virus type 1 (HIV-1) from the cell surface ..
  8. pmc Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirus
    Mandana Mansouri
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Virol 83:9672-81. 2009
    ..VPU, reduced steady-state levels of bone marrow stromal cell antigen 2 (BST2; also called CD317 or tetherin), suggesting that BST2 might be a novel substrate of K5 and VPU...
  9. pmc HIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomes
    Yukie Iwabu
    Department of Pathology, National Institute of Infectious Diseases, Tokyo 162 8640, Japan
    J Biol Chem 284:35060-72. 2009
    b>Bone marrow stromal antigen 2 (BST-2, also known as tetherin) is a recently identified interferon-inducible host restriction factor that can block the production of enveloped viruses by trapping virus particles at the cell surface...
  10. pmc HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation
    Bastien Mangeat
    Department of Dermatology and Venereology, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland
    PLoS Pathog 5:e1000574. 2009
    Host cells impose a broad range of obstacles to the replication of retroviruses. Tetherin (also known as CD317, BST-2 or HM1.24) impedes viral release by retaining newly budded HIV-1 virions on the surface of cells...
  11. pmc BST-2/tetherin: a new component of the innate immune response to enveloped viruses
    David T Evans
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, One Pine Hill Drives, Southborough, MA 01772, USA
    Trends Microbiol 18:388-96. 2010
    The interferon-inducible, transmembrane protein BST-2 (CD317, tetherin) directly holds fully formed enveloped virus particles to the cells that produce them, inhibiting their spread...
  12. pmc Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion
    Ravindra K Gupta
    Medical Research Council Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London, United Kingdom
    PLoS Pathog 5:e1000443. 2009
    The recently identified restriction factor tetherin/BST-2/CD317 is an interferon-inducible trans-membrane protein that restricts HIV-1 particle release in the absence of the HIV-1 countermeasure viral protein U (Vpu)...
  13. doi Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses
    Frank Kirchhoff
    Institute of Molecular Virology, University Hospital Ulm, Meyerhofstrasse 1, 89081 Ulm, Germany
    Cell Host Microbe 8:55-67. 2010
    ....
  14. pmc Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestration
    Ravindra K Gupta
    Medical Research Council Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, United Kingdom
    Proc Natl Acad Sci U S A 106:20889-94. 2009
    b>Tetherin is an IFN-inducible restriction factor that inhibits HIV-1 particle release in the absence of the HIV-1 countermeasure, viral protein U (Vpu)...
  15. pmc Tetherin restricts productive HIV-1 cell-to-cell transmission
    Nicoletta Casartelli
    Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, Paris, France
    PLoS Pathog 6:e1000955. 2010
    The IFN-inducible antiviral protein tetherin (or BST-2/CD317/HM1.24) impairs release of mature HIV-1 particles from infected cells. HIV-1 Vpu antagonizes the effect of tetherin...
  16. pmc Cell-cell spread of human immunodeficiency virus type 1 overcomes tetherin/BST-2-mediated restriction in T cells
    Clare Jolly
    MRC Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, Windeyer Building, London, United Kingdom
    J Virol 84:12185-99. 2010
    ..b>Tetherin (BST-2/CD317) is an interferon-induced, antiretroviral restriction factor that inhibits nascent cell-free ..
  17. pmc Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin
    Sheli R Radoshitzky
    U S Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Fort Detrick, Frederick, MD 21702, USA
    J Virol 84:10569-80. 2010
    b>Bone marrow stromal antigen 2 (BST-2/tetherin) is a cellular membrane protein that inhibits the release of HIV-1...
  18. pmc Vpu enhances HIV-1 virus release in the absence of Bst-2 cell surface down-modulation and intracellular depletion
    Eri Miyagi
    Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
    Proc Natl Acad Sci U S A 106:2868-73. 2009
    HIV-1 Vpu enhances the release of virions from infected cells. Recent work identified Bst-2/CD317/tetherin as a host factor whose inhibitory activity on viral release is counteracted by Vpu...
  19. pmc Identification of amino acids in the human tetherin transmembrane domain responsible for HIV-1 Vpu interaction and susceptibility
    Tomoko Kobayashi
    Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Virol 85:932-45. 2011
    b>Tetherin, also known as BST-2/CD317/HM1.24, is an antiviral cellular protein that inhibits the release of HIV-1 particles from infected cells...
  20. pmc CD317/tetherin is enriched in the HIV-1 envelope and downregulated from the plasma membrane upon virus infection
    Anja Habermann
    Department of Infectious Diseases, Virology, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    J Virol 84:4646-58. 2010
    CD317/Bst-2/tetherin is a host factor that restricts the release of human immunodeficiency virus type 1 (HIV-1) by trapping virions at the plasma membrane of certain producer cells. It is antagonized by the HIV-1 accessory protein Vpu...
  21. pmc HM1.24 is internalized from lipid rafts by clathrin-mediated endocytosis through interaction with alpha-adaptin
    Naoko Masuyama
    Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    J Biol Chem 284:15927-41. 2009
    HM1.24/Bst2/CD317 is a protein highly expressed in multiple myeloma cells and has unique topology with two membrane anchor domains, an NH2-terminal transmembrane domain and a glycosylphosphatidylinositol attached to the COOH terminus...
  22. pmc Antagonism of CD317 restriction of human immunodeficiency virus type 1 (HIV-1) particle release and depletion of CD317 are separable activities of HIV-1 Vpu
    Christine Goffinet
    Department of Infectious Diseases, Virology, University of Heidelberg, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    J Virol 84:4089-94. 2010
    Vpu antagonizes human immunodeficiency virus type 1 (HIV-1) particle release inhibition by CD317/BST-2/Tetherin. Whether this Vpu activity strictly requires cellular depletion of the restriction factor is unclear...
  23. pmc Quantitative multicolor super-resolution microscopy reveals tetherin HIV-1 interaction
    Martin Lehmann
    Department of Microbiology and Molecular Medicine, University Hospital and Medical School of Geneva, Geneva, Switzerland
    PLoS Pathog 7:e1002456. 2011
    ..The cellular restriction factor tetherin (also known as CD317, BST-2 or HM1...
  24. pmc Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment
    Mathieu Dubé
    Laboratory of Human Retrovirology, Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec, Canada
    PLoS Pathog 6:e1000856. 2010
    The Vpu accessory protein promotes HIV-1 release by counteracting Tetherin/BST-2, an interferon-regulated restriction factor, which retains virions at the cell-surface...
  25. pmc HIV-1 Vpu protein antagonizes innate restriction factor BST-2 via lipid-embedded helix-helix interactions
    Mark Skasko
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Biol Chem 287:58-67. 2012
    The Vpu protein of HIV-1 antagonizes BST-2 (tetherin), a broad spectrum effector of the innate immune response to viral infection, by an intermolecular interaction that maps genetically to the α-helical transmembrane domains (TMDs) of ..
  26. pmc In vivo expression profile of the antiviral restriction factor and tumor-targeting antigen CD317/BST-2/HM1.24/tetherin in humans
    Elina Erikson
    Department of Infectious Diseases, University of Heidelberg, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 108:13688-93. 2011
    Human CD317 is an intrinsic immunity factor that restricts the release of enveloped viruses, including the major pathogens HIV and Lassa virus, from infected cells in culture...
  27. pmc Tetherin does not significantly restrict dendritic cell-mediated HIV-1 transmission and its expression is upregulated by newly synthesized HIV-1 Nef
    Christopher M Coleman
    Center for Retrovirus Research, Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    Retrovirology 8:26. 2011
    ..b>Tetherin is a type I IFN-inducible restriction factor that blocks HIV-1 release and modulates CD4+ T cell-mediated cell-to-..
  28. pmc Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin
    Nolwenn Jouvenet
    Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York, USA
    J Virol 83:1837-44. 2009
    ..A recently identified IFN-induced antiretroviral protein, termed tetherin (previously known as BST-2 or CD317), blocks the release of nascent human immunodeficiency virus type 1 (HIV-1) ..
  29. pmc Tetherin restricts direct cell-to-cell infection of HIV-1
    Björn D Kuhl
    McGill University AIDS Center, Lady Davis Institute, Jewish General Hospital, Montreal, Canada
    Retrovirology 7:115. 2010
    b>Tetherin (BST-2/CD317/HM1...
  30. pmc A cytoplasmic tail determinant in HIV-1 Vpu mediates targeting of tetherin for endosomal degradation and counteracts interferon-induced restriction
    Tonya Kueck
    Department of Infectious Disease, King s College London School of Medicine, Guy s Hospital, London, United Kingdom
    PLoS Pathog 8:e1002609. 2012
    The HIV-1 accessory protein Vpu counteracts tetherin (BST-2/CD317) by preventing its incorporation into virions, reducing its surface expression, and ultimately promoting its degradation...
  31. pmc HIV-1 Vpu blocks recycling and biosynthetic transport of the intrinsic immunity factor CD317/tetherin to overcome the virion release restriction
    Sarah Schmidt
    Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany
    MBio 2:e00036-11. 2011
    The intrinsic immunity factor CD317 (BST-2/HM1.24/tetherin) imposes a barrier to HIV-1 release at the cell surface that can be overcome by the viral protein Vpu...
  32. pmc Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction
    Anna Le Tortorec
    Department of Infectious Disease, King s College London School of Medicine, Guy s Hospital, London SE19RT, UK
    Viruses 3:520-40. 2011
    b>Tetherin (BST2/CD317) has been recently recognized as a potent interferon-induced antiviral molecule that inhibits the release of diverse mammalian enveloped virus particles from infected cells...
  33. pmc Ancient adaptive evolution of tetherin shaped the functions of Vpu and Nef in human immunodeficiency virus and primate lentiviruses
    Efrem S Lim
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, P O Box 10924, Seattle, WA 98109 1024, USA
    J Virol 84:7124-34. 2010
    b>Tetherin/BST-2 is a host-encoded protein that restricts a wide diversity of viruses at the stage of virion release. However, viruses have evolved antagonists of Tetherin, including the Vpu and Nef proteins of primate lentiviruses...
  34. pmc Endogenous CD317/Tetherin limits replication of HIV-1 and murine leukemia virus in rodent cells and is resistant to antagonists from primate viruses
    Christine Goffinet
    Department of Infectious Diseases, Virology, University of Heidelberg, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    J Virol 84:11374-84. 2010
    Human CD317 (BST-2/tetherin) is an intrinsic immunity factor that blocks the release of retroviruses, filoviruses, herpesviruses, and arenaviruses...
  35. pmc The great escape: viral strategies to counter BST-2/tetherin
    Janet L Douglas
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America
    PLoS Pathog 6:e1000913. 2010
    ..that virions remain attached to the surface of BST-2-expressing cells led to the renaming of BST-2 as "tetherin"...
  36. pmc Inhibition of Lassa and Marburg virus production by tetherin
    Toshie Sakuma
    First Department of Forensic Science, National Research Institute of Police Science, Kashiwa 277 0882, Japan
    J Virol 83:2382-5. 2009
    Recently, tetherin has been identified as an effective cellular factor that prevents the release of human immunodeficiency virus type 1...
  37. pmc HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment
    Heiko Hauser
    Department of Molecular Microbiology and Immunology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Retrovirology 7:51. 2010
    ..to the surface of human cells due to the action of an interferon-inducible cellular restriction factor, BST-2/tetherin. Tetherin also restricts the release of other enveloped viral particles and is counteracted by a several viral ..
  38. pmc Determinants of tetherin antagonism in the transmembrane domain of the human immunodeficiency virus type 1 Vpu protein
    Raphaël Vigan
    Department of Infectious Disease, King s College London School of Medicine, Guy s Hospital, London SE1 9RT, United Kingdom
    J Virol 84:12958-70. 2010
    b>Tetherin (BST2/CD317) potently restricts the particle release of human immunodeficiency virus type 1 (HIV-1) mutants defective in the accessory gene vpu...
  39. pmc Nef proteins from simian immunodeficiency viruses are tetherin antagonists
    Fengwen Zhang
    Aaron Diamond AIDS Research Center, Laboratory of Retrovirology, The Rockefeller University, New York, NY 10016, USA
    Cell Host Microbe 6:54-67. 2009
    The tetherin/BST2/CD317 protein blocks the release of HIV-1 and other enveloped viruses by inducing tethering of nascent particles to infected cell surfaces...
  40. doi HIV-1 accessory proteins--ensuring viral survival in a hostile environment
    Michael H Malim
    Department of Infectious Diseases, King s College London School of Medicine, 2nd Floor, Borough Wing, Guy s Hospital, London Bridge, London, SE1 9RT, UK
    Cell Host Microbe 3:388-98. 2008
    ..Broadly speaking, the HIV-1 accessory proteins modify the local environment within infected cells to ensure viral persistence, replication, dissemination, and transmission...
  41. pmc Modulation of HIV-1-host interaction: role of the Vpu accessory protein
    Mathieu Dubé
    Laboratory of Human Retrovirology, Institut de Recherches Cliniques de Montreal, 110, avenue des Pins Ouest, Montreal, Quebec, Canada H2W 1R7
    Retrovirology 7:114. 2010
    ..Second, it enhances the release of progeny virions from infected cells by antagonizing Tetherin, an interferon (IFN)-regulated host restriction factor that directly cross-links virions on host cell-surface...
  42. pmc Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu
    Andrey A Tokarev
    Department of Medicine University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0679, USA
    J Virol 85:51-63. 2011
    The HIV-1 protein Vpu counteracts the antiviral activity of the innate restriction factor BST-2/tetherin by a mechanism that partly depends on its interaction with β-TrCP, a substrate adaptor for an SCF (Skp-Cullin 1-F box) E3 ubiquitin ..
  43. pmc Anti-tetherin activities in Vpu-expressing primate lentiviruses
    Su Jung Yang
    Department of Molecular Microbiology and Immunology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Retrovirology 7:13. 2010
    The anti-viral activity of the cellular restriction factor, BST-2/tetherin, was first observed as an ability to block the release of Vpu-minus HIV-1 from the surface of infected cells...
  44. pmc Immunoelectron microscopic evidence for Tetherin/BST2 as the physical bridge between HIV-1 virions and the plasma membrane
    Jason Hammonds
    Department of Pediatrics and Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA
    PLoS Pathog 6:e1000749. 2010
    b>Tetherin/BST2 was identified in 2008 as the cellular factor responsible for restricting HIV-1 replication at a very late stage in the lifecycle...
  45. pmc Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain
    Andreas Hinz
    Unit of Virus Host Cell Interactions UVHCI UMI 3265 Université Joseph Fourier EMBL CNRS, 38042 Grenoble, France
    Cell Host Microbe 7:314-23. 2010
    The restriction factor BST-2/tetherin contains two membrane anchors employed to retain some enveloped viruses, including HIV-1 tethered to the plasma membrane in the absence of virus-encoded antagonists. The 2...
  46. pmc Innate sensing of HIV-1 assembly by Tetherin induces NFκB-dependent proinflammatory responses
    Rui Pedro Galao
    Department of Infectious Disease, King s College London School of Medicine, Guy s Hospital, London SE1 9RT, UK
    Cell Host Microbe 12:633-44. 2012
    ..Here we investigated whether the interferon-induced viral restriction factor tetherin (CD317/BST2), which is known to inhibit HIV-1 particle release by physically tethering virions to the cell ..
  47. pmc Ebola virus glycoprotein counteracts BST-2/Tetherin restriction in a sequence-independent manner that does not require tetherin surface removal
    Lisa A Lopez
    Department of Molecular Microbiology and Immunology, USC Keck School of Medicine, 2011 Zonal Ave, HMR502, Los Angeles, CA 90033, USA
    J Virol 84:7243-55. 2010
    BST-2/tetherin is an interferon-inducible protein that restricts the release of enveloped viruses from the surface of infected cells by physically linking viral and cellular membranes...
  48. pmc HIV-1 Group P is unable to antagonize human tetherin by Vpu, Env or Nef
    Daniel Sauter
    Institute of Molecular Virology, Ulm University Medical Center, 89069, Ulm, Germany
    Retrovirology 8:103. 2011
    ..Group O or rare Group N viruses, efficiently antagonize the human orthologue of the restriction factor tetherin (BST-2, HM1...
  49. pmc BST-2 diminishes HIV-1 infectivity
    Jianyong Zhang
    McGill AIDS Centre, Lady Davis Institute, Jewish General Hospital, 3755 Cote Ste Catherine, Montreal, Quebec, Canada
    J Virol 84:12336-43. 2010
    Bone marrow stromal cell antigen 2 (BST-2, also known as tetherin/CD317/HM1.24) inhibits the release of human immunodeficiency virus type 1 (HIV-1) and other enveloped viruses by tethering virus particles to the cell surface...
  50. pmc The transmembrane domain of BST-2 determines its sensitivity to down-modulation by human immunodeficiency virus type 1 Vpu
    Liwei Rong
    McGill AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Virol 83:7536-46. 2009
    Bone marrow stromal cell antigen 2 (BST-2, also known as tetherin) restricts the production of a number of enveloped viruses by blocking virus release from the cell surface...
  51. pmc The ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation
    Katy Janvier
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    PLoS Pathog 7:e1001265. 2011
    ..Here, we show an additional role for the ESCRT machinery in HIV-1 release. BST-2/tetherin is a restriction factor that impedes HIV release by tethering mature virus particles to the plasma membrane...
  52. pmc Compensatory changes in the cytoplasmic tail of gp41 confer resistance to tetherin/BST-2 in a pathogenic nef-deleted SIV
    Ruth Serra-Moreno
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    Cell Host Microbe 9:46-57. 2011
    b>Tetherin (BST-2 or CD317) is an interferon-inducible transmembrane protein that inhibits virus release from infected cells...
  53. pmc Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2
    Bin Jia
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA, USA
    PLoS Pathog 5:e1000429. 2009
    b>Tetherin, also known as BST2, CD317 or HM1.24, was recently identified as an interferon-inducible host-cell factor that interferes with the detachment of virus particles from infected cells...
  54. pmc Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue
    Michael Schindler
    Heinrich Pette Institute for Experimental Virology and Immunology, Martinistrasse 52, 20251 Hamburg, Germany
    Retrovirology 7:1. 2010
    ..human immunodeficiency virus type 1 (HIV-1) Vpu protein degrades CD4 and counteracts a restriction factor termed tetherin (CD317; Bst-2) to enhance virion release...
  55. pmc Direct restriction of virus release and incorporation of the interferon-induced protein BST-2 into HIV-1 particles
    Kathleen Fitzpatrick
    Department of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS Pathog 6:e1000701. 2010
    ..on the surface of infected cells by the interferon-induced, transmembrane and GPI-anchored protein BST-2 (CD317; tetherin). BST-2 inhibits diverse families of enveloped viruses, but how it restricts viral release is unclear...
  56. pmc β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release
    Hanna Mari Tervo
    Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany
    Retrovirology 8:9. 2011
    The cellular transmembrane protein CD317/BST-2/HM1.24/Tetherin restricts HIV-1 infection by physically tethering mature virions to the surface of infected cells...
  57. pmc Influenza virus partially counteracts restriction imposed by tetherin/BST-2
    Bastien Mangeat
    Department of Dermatology and Wound Healing, Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, Wales, United Kingdom
    J Biol Chem 287:22015-29. 2012
    ..Interestingly, a recently identified IFN-induced cellular protein, tetherin (also known as CD317, BST-2, or HM1...
  58. pmc Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variants
    Matthew W McNatt
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York, United States of America
    PLoS Pathog 5:e1000300. 2009
    b>Tetherin/BST-2/CD317 is a recently identified antiviral protein that blocks the release of nascent retrovirus, and other virus, particles from infected cells. An HIV-1 accessory protein, Vpu, acts as an antagonist of tetherin...
  59. pmc Virus-activated interferon regulatory factor 7 upregulates expression of the interferon-regulated BST2 gene independently of interferon signaling
    Mariana G Bego
    Laboratory of Human Retrovirology, Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada
    J Virol 86:3513-27. 2012
    BST-2/tetherin is an interferon (IFN)-inducible host restriction factor that inhibits the release of many enveloped viruses and functions as a negative-feedback regulator of IFN production by plasmacytoid dendritic cells...
  60. pmc Upregulation of BST-2/Tetherin by HIV infection in vivo
    Stefanie Homann
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0679, USA
    J Virol 85:10659-68. 2011
    ..The data further suggest that this upregulation is sufficient to saturate the activity of Vpu and inhibit wild-type HIV...
  61. pmc Antiviral activity of the interferon-induced cellular protein BST-2/tetherin
    Andrey Tokarev
    Department of Medicine, University of California San Diego, California 92093 0679, USA
    AIDS Res Hum Retroviruses 25:1197-210. 2009
    ..study of HIV-1 Vpu recently led to the discovery of the interferon-induced transmembrane protein BST-2 (CD317; tetherin) as a novel component of the innate defense against enveloped viruses...
  62. pmc Ubiquitination of BST-2 protein by HIV-1 Vpu protein does not require lysine, serine, or threonine residues within the BST-2 cytoplasmic domain
    Jean K Gustin
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Biol Chem 287:14837-50. 2012
    The cellular protein BST-2/CD317/Tetherin has been shown to inhibit the release of HIV-1 and other enveloped viruses from infected cells...
  63. pmc Structural and biophysical analysis of BST-2/tetherin ectodomains reveals an evolutionary conserved design to inhibit virus release
    Melissa Swiecki
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 286:2987-97. 2011
    BST-2/tetherin is a host antiviral molecule that functions to potently inhibit the release of enveloped viruses from infected cells. In return, viruses have evolved antagonists to this activity...
  64. pmc Differential effects of human immunodeficiency virus type 1 Vpu on the stability of BST-2/tetherin
    Amy J Andrew
    Viral Biochemistry Section, Laboratory of Molecular Microbiology, NIAID, NIH, Bldg 4, Room 310, 4 Center Drive, MSC 0460, Bethesda, MD 20892 0460, USA
    J Virol 85:2611-9. 2011
    BST-2/CD317/tetherin is a host factor that inhibits the release of HIV-1 and other unrelated viruses. A current model proposes that BST-2 physically tethers virions to the surface of virus-producing cells...
  65. doi Tetherin: holding on and letting go
    Daniel Sauter
    Institute of Molecular Virology, University Clinic Ulm, Meyerhofstrasse 1, 89081 Ulm, Germany
    Cell 141:392-8. 2010
    ..This Essay discusses the host restriction factor tetherin, which blocks the release of enveloped viruses like HIV-1, and the factors evolved by primate lentiviruses, such ..
  66. pmc The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin
    Claire Pardieu
    MRC Centre for Medical Molecular Virology, University College London, London, United Kingdom
    PLoS Pathog 6:e1000843. 2010
    b>Tetherin (CD317/BST2) is an interferon-induced membrane protein that inhibits the release of diverse enveloped viral particles...
  67. pmc Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations
    Heidi L Schubert
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112 5650, USA
    Proc Natl Acad Sci U S A 107:17951-6. 2010
    HIV-1 and other enveloped viruses can be restricted by a host cellular protein called BST2/tetherin that prevents release of budded viruses from the cell surface...
  68. pmc Role of the endocytic pathway in the counteraction of BST-2 by human lentiviral pathogens
    David Lau
    University of California at San Diego, La Jolla, CA 92093 0679, USA
    J Virol 85:9834-46. 2011
    The interferon-inducible transmembrane protein BST-2 (CD317, tetherin) restricts the release of several enveloped viruses from infected cells. BST-2 is broadly active against retroviruses, including HIV-1 and HIV-2...
  69. pmc Budding capability of the influenza virus neuraminidase can be modulated by tetherin
    Mark A Yondola
    Mount Sinai School of Medicine, 1 Gustave L Levy Place, Department of Microbiology, Annenberg Bldg 16 20, New York, NY 10128, USA
    J Virol 85:2480-91. 2011
    ..Most importantly, we demonstrate that the antiviral restriction factor tetherin plays a role in determining the strain-specific limitations of release competency...
  70. pmc Influenza virus is not restricted by tetherin whereas influenza VLP production is restricted by tetherin
    Rie Watanabe
    Howard Hughes Medical Institute, Dept of Molecular Biosciences, Northwestern University, Evanston, IL 60201 2138, USA
    Virology 417:50-6. 2011
    b>Tetherin (ST2/CD317) is a cellular protein that restricts the release from cells of some enveloped viruses including HIV-1...
  71. pmc Separable determinants of subcellular localization and interaction account for the inability of group O HIV-1 Vpu to counteract tetherin
    Raphaël Vigan
    Department of Infectious Disease, King s College London School of Medicine, Guy s Hospital, London SE1 9RT, UK
    J Virol 85:9737-48. 2011
    b>Tetherin (BST-2/CD317) is thought to restrict retroviral particle release by cross-linking nascent viral and cellular membranes...
  72. pmc Dimerization of tetherin is not essential for its antiviral activity against Lassa and Marburg viruses
    Toshie Sakuma
    First Department of Forensic Science, National Research Institute of Police Science, Kashiwa, Japan
    PLoS ONE 4:e6934. 2009
    b>Tetherin (also known as BST2, CD317 or HM1.24) has recently been reported to inhibit a wide range of viruses. However, the antiviral mechanism of action of tetherin has not been determined...
  73. pmc Expression analysis of LEDGF/p75, APOBEC3G, TRIM5alpha, and tetherin in a Senegalese cohort of HIV-1-exposed seronegative individuals
    Kim Mous
    Laboratory for Proteinscience, Proteomics and Epigenetic Signaling, Department of Biomedical Sciences, University of Antwerp, Wilrijk, Belgium
    PLoS ONE 7:e33934. 2012
    ..apolipoprotein B mRNA-editing catalytic polypeptide-like 3G (APOBEC3G), tripartite motif 5alpha (TRIM5α), and tetherin exert anti-HIV activity...
  74. pmc Rab7A is required for efficient production of infectious HIV-1
    Marina Caillet
    INSERM, U1016, Institut Cochin, Paris, France
    PLoS Pathog 7:e1002347. 2011
    ..We also show that siRNA-mediated Rab7A depletion induces a BST2/Tetherin phenotype on HIV-1 release...
  75. doi HIV-1 Vpu antagonizes BST-2 by interfering mainly with the trafficking of newly synthesized BST-2 to the cell surface
    Mathieu Dubé
    Laboratory of Human Retrovirology, Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, Quebec, Canada
    Traffic 12:1714-29. 2011
    ....
  76. pmc Role of retroviral restriction factors in the interferon-α-mediated suppression of HIV-1 in vivo
    Satish K Pillai
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 109:3035-40. 2012
    ..B mRNA editing enzyme, catalytic polypeptide 3 (APOBEC3) and bone marrow stromal cell antigen 2 (BST-2/tetherin/CD317) retroviral restriction factors underlies the IFN-α-mediated suppression of HIV-1 replication in vitro...
  77. pmc Polarity changes in the transmembrane domain core of HIV-1 Vpu inhibits its anti-tetherin activity
    Mingyu Lv
    National Engineering Laboratory for AIDS Vaccine, College of Life Science, Jilin University, Changchun, Jilin Province, People s Republic of China
    PLoS ONE 6:e20890. 2011
    b>Tetherin (BST-2/CD317) is an interferon-inducible antiviral protein that restricts the release of enveloped viruses from infected cells. The HIV-1 accessory protein Vpu can efficiently antagonize this restriction...
  78. pmc Vpu augments the initial burst phase of HIV-1 propagation and downregulates BST2 and CD4 in humanized mice
    Kei Sato
    Center for Emerging Virus Research, Kyoto University, Sakyo ku, Kyoto, Japan
    J Virol 86:5000-13. 2012
    ..b>BST2 was identified as an inhibitory cellular protein of HIV-1 replication, which tethers virions to the cell surface to ..
  79. doi Intrinsic cellular defenses against human immunodeficiency viruses
    Daniel Blanco-Melo
    Howard Hughes Medical Institute, Laboratory of Retrovirology, Aaron Diamond AIDS Research Center, The Rockefeller University, 455 First Avenue, New York, NY 10016, USA
    Immunity 37:399-411. 2012
    ..Among these are several classes of proteins (APOBEC3, TRIM5, Tetherin, and SAMHD1) that inhibit the replication of human and simian immunodeficiency viruses...
  80. pmc Some human immunodeficiency virus type 1 Vpu proteins are able to antagonize macaque BST-2 in vitro and in vivo: Vpu-negative simian-human immunodeficiency viruses are attenuated in vivo
    Masashi Shingai
    NIAID, NIH, Bethesda, MD 20892 0460, USA
    J Virol 85:9708-15. 2011
    ..virus type 1 (HIV-1) Vpu enhances the release of viral particles from infected cells by targeting BST-2/tetherin, a cellular protein inhibiting virus release...
  81. pmc Tetherin and its viral antagonists
    Björn D Kuhl
    McGill AIDS Centre, Lady Davis Institute Jewish General Hospital, Montreal, Quebec, Canada H3T 1E2
    J Neuroimmune Pharmacol 6:188-201. 2011
    ..number of well-characterized interferon-inducible antiviral factors such as RNaseL/OAS, ISG15, Mx, PKR, and ADAR, tetherin (BST-2/CD317/HM1...
  82. pmc BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action
    Mark Skasko
    Department of Pathology, University of California San Diego, La Jolla, CA 92093 0679, USA
    Virology 411:65-77. 2011
    ..domain (TMD) interactions are essential for HIV-1 Vpu-mediated antagonism of the restriction factor BST-2/tetherin. We made Vpu TMD mutants to study the mechanism of BST-2 antagonism...
  83. pmc SIV Nef proteins recruit the AP-2 complex to antagonize Tetherin and facilitate virion release
    Fengwen Zhang
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York, United States of America
    PLoS Pathog 7:e1002039. 2011
    ..Nef proteins from many simian immunodefiency viruses were shown to antagonize a cellular antiviral protein, named Tetherin, that blocks release of viral particles from the cell surface...
  84. pmc Tetherin inhibits prototypic foamy virus release
    Fengwen Xu
    Key Laboratory of Molecular Microbiology and Biotechnology Ministry of Education and Key Laboratory of Microbial Functional Genomics Tianjin, College of Life Sciences, Nankai University, Tianjin 300071, China
    Virol J 8:198. 2011
    b>Tetherin (also known as BST-2, CD317, and HM1.24) is an interferon- induced protein that blocks the release of a variety of enveloped viruses, such as retroviruses, filoviruses and herpesviruses...
  85. pmc Lack of adaptation to human tetherin in HIV-1 group O and P
    Su Jung Yang
    Department of Molecular Microbiology and Immunology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    Retrovirology 8:78. 2011
    ..it has been reported that the group M Vpu protein is capable of both down-modulating CD4 and counteracting BST-2/tetherin restriction, while the group O Vpu cannot antagonize tetherin...
  86. pmc Human immunodeficiency virus, restriction factors, and interferon
    Stuart Neil
    Department of Infectious Disease, King s College London School of Medicine, Guy s Hospital, London, United Kingdom
    J Interferon Cytokine Res 29:569-80. 2009
    ..Such knowledge could allow for novel forms of therapeutic intervention in pathogenic retroviral infections, as well as the development of animal models of human disease...
  87. pmc Structural insight into the mechanisms of enveloped virus tethering by tetherin
    HaiTao Yang
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 8114, USA
    Proc Natl Acad Sci U S A 107:18428-32. 2010
    b>Tetherin/BST2 is a type-II membrane protein that inhibits the release of a range of enveloped viruses, including HIV-1...
  88. pmc Antagonism to and intracellular sequestration of human tetherin by the human immunodeficiency virus type 2 envelope glycoprotein
    Anna Le Tortorec
    Department of Infectious Disease, King s College London School of Medicine, Guy s Hospital, London SE1 9RT, United Kingdom
    J Virol 83:11966-78. 2009
    b>Tetherin (CD317/BST-2), an interferon-induced membrane protein, restricts the release of nascent retroviral particles from infected cell surfaces...
  89. pmc The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain
    Monica Agromayor
    Department of Infectious Diseases, King s College London School of Medicine, London SE1 9RT, UK
    Structure 20:414-28. 2012
    ..that UBAP1-containing ESCRT-I is essential for degradation of antiviral cell-surface proteins, such as tetherin (BST-2/CD317), by viral countermeasures, namely, the HIV-1 accessory protein Vpu and the Kaposi sarcoma-..
  90. pmc HIV-1 Vpu targets cell surface markers CD4 and BST-2 through distinct mechanisms
    Amy Andrew
    Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892 0460, USA
    Mol Aspects Med 31:407-17. 2010
    ..24, or tetherin) and requires Vpu's TM domain...
  91. pmc BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction
    Kei Miyakawa
    AIDS Research Center, National Institute of Infectious Diseases, Shinjuku ku, Tokyo, Japan
    PLoS Pathog 5:e1000700. 2009
    ..Recent reports have identified a previously uncharacterized transmembrane protein, tetherin/CD317/BST-2, as a crucial host restriction factor that acts during a late budding step in HIV-1 replication by ..
  92. pmc Regulation of porcine endogenous retrovirus release by porcine and human tetherins
    Giada Mattiuzzo
    Wohl Virion Centre, Division of Infection and Immunity, University College London, London, United Kingdom
    J Virol 84:2618-22. 2010
    ..Human tetherin, recently described as an antiviral protein able to inhibit the release of enveloped viruses, and its porcine ..
  93. pmc A flow cytometry-based FRET assay to identify and analyse protein-protein interactions in living cells
    Carina Banning
    Heinrich Pette Institute for Experimental Virology and Immunology, Hamburg, Germany
    PLoS ONE 5:e9344. 2010
    ....
  94. ncbi Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth
    J Ishikawa
    Division of Molecular Oncology, Osaka University Medical School, Japan
    Genomics 26:527-34. 1995
    ..The BST-2 gene (HGMW-approved symbol BST2) is located on chromosome 19p13.2...
  95. ncbi Characterization of antibodies submitted to the B cell section of the 8th Human Leukocyte Differentiation Antigens Workshop by flow cytometry and immunohistochemistry
    Miriam Vidal-Laliena
    Immunology Unit, Department of Cellular Biology and Pathology, Medical School, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Casanova 143, Barcelona E 08036, Spain
    Cell Immunol 236:6-16. 2005
    ..Our results have permitted us to characterize the expression of 10 new CD molecules: CD316 (HM1.24, BST2), CD268 (BAFF-R, TNFRSF13C), CD269 (BCMA, TNFRF17), CD267 (TACI, TNFRSF13B), CD275 (ICOSL, B7H2), CD254 (TRANCE, ..
  96. pmc The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu
    Amy J Andrew
    Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 0460, USA
    Retrovirology 6:80. 2009
    ..Recent work identified BST-2/CD317 as a host factor that inhibits HIV-1 virus release in a Vpu sensitive manner...
  97. ncbi Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells
    T Ohtomo
    Chugai Pharmaceutical Co, Ltd, Fuji Gotemba Research Labs, 1 135 Komakado, Gotemba shi, Shizuoka, 412 8513, Japan
    Biochem Biophys Res Commun 258:583-91. 1999
    ..antigen is a type II membrane glycoprotein, which has been reported as a bone marrow stromal cell surface antigen BST2, and may exist as a homodimer on myeloma cell surface...
  98. doi BST-2 mediated restriction of simian-human immunodeficiency virus
    Autumn Ruiz
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Virology 406:312-21. 2010
    ..24; CD317; tetherin) inhibition of virus release in a species-specific manner...
  99. pmc A CD317/tetherin-RICH2 complex plays a critical role in the organization of the subapical actin cytoskeleton in polarized epithelial cells
    Ruth Rollason
    Department of Biochemistry, University of Bristol, Bristol BS8 1TD, England, UK
    J Cell Biol 184:721-36. 2009
    CD317/tetherin is a lipid raft-associated integral membrane protein with a novel topology. It has a short N-terminal cytosolic domain, a conventional transmembrane domain, and a C-terminal glycosyl-phosphatidylinositol anchor...
  100. pmc Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction
    Wei Cao
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    J Exp Med 206:1603-14. 2009
    ..an ILT7 ligand expressed by human cell lines and identified it as bone marrow stromal cell antigen 2 (BST2; CD317)...
  101. pmc Comparative study on the effect of human BST-2/Tetherin on HIV-1 release in cells of various species
    Kei Sato
    Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, Kyoto, Kyoto 606 8507, Japan
    Retrovirology 6:53. 2009
    ..The cell type-specific effect of hBST-2 may be critical to elucidate the mechanism of BST-2-dependent suppression of virus release...

Research Grants103 found, 100 shown here

  1. Role of VPU in Retroviral Particle Assembly
    Paul W Spearman; Fiscal Year: 2011
    ..Vpu inhibits a potent cellular restriction to release that was identified in 2008 as BST2 or tetherin. The overall goals of this project are to define the mechanism of restriction of particle release by tetherin, ..
  2. Interactions of Ebola virus glycoproteins with host cells
    PAUL F BATES; Fiscal Year: 2010
    ..b>Tetherin/BST-2 is a recently described intrinsic cellular antiviral factor that is active against a number of enveloped ..
  3. Immune evasion by gamma 2 Herpesviruses
    KLAUS J FRUEH; Fiscal Year: 2010
    ..ALCAM, CD3IIPECAM, VE-Cadherin, alpha and beta- Catenin) and the interferon-induced antiviral protein B ST2/Tetherin. We therefore hypothesize that K5 modulates innate immune defense as well as angioproliferative and inflammatory ..
  4. HIV-1 Vpu and BST-2/CD317
    John Guatelli; Fiscal Year: 2009
    ..24, CD317, or "tetherin." BST-2 seems able to affect diverse enveloped virions, suggesting a broad role in the host defense against ..
  5. PERIPHERAL NEUROPATHY IN LENTIVIRUS INFECTIONS: EARLY VIRAL AND HOST DETERMINANTS
    Christopher Power; Fiscal Year: 2010
    ..Many of the scientific techniques and models to be employed in the experiments described herein are unique to the laboratories of this team of investigators who have worked together for many years. ..
  6. LENTIVIRUS-INDUCED NEUROPATHY: VIRAL DIVERSITY AND HOST*
    Christopher Power; Fiscal Year: 2004
    ..From these studies, we expect to gain insights into this common neurological complication in terms of lentivirus-induced neurovirulence and pathogenic host responses. ..
  7. NEUROTOXIC MECHANISMS MEDIATED BY LENTIVIRUS-INDUCED PROTEOLYSIS
    Christopher Power; Fiscal Year: 2007
    ..The information derived from this proposal will be applicable to the prevention and treatment of HIV-associated brain disease. ..
  8. Human Endogenous Retroelements in HIV Immunopathogenesis
    Douglas F Nixon; Fiscal Year: 2010
    ..This information will be used to devise future studies to treat HIV infection and design a novel vaccine against HIV/AIDS. ..
  9. T Regulatory Cells in HIV Infection
    Douglas F Nixon; Fiscal Year: 2010
    ..The goal of this proposal is to generate data to determine the importance of Treg cells in HIV infection. Manipulation of Treg cells could be critical for vaccine strategies and for therapeutic interventions. ..
  10. DRUG ABUSE, SUBSTANCE P AND HIV
    Wenzhe Ho; Fiscal Year: 2007
    ....
  11. Opioids, HIV/HCV and Host Cell Innate Immunity
    Wenzhe Ho; Fiscal Year: 2007
    ..abstract_text> ..
  12. LEDGF-Integrase Structural Biology
    Alan Engelman; Fiscal Year: 2005
    ..abstract_text> ..
  13. Drug Abuse, Sustance P and HIV
    Wenzhe Ho; Fiscal Year: 2010
    ..Our studies also will facilitate a rational basis for practical guidance towards the reduction of risk factors, such as heroin, that may potentiate HIV-1 infection and promote the development and progression of neuroAIDS. ..
  14. HIV-1 Vpu and BST-2/CD317
    John Guatelli; Fiscal Year: 2011
    ..24, CD317, or "tetherin." BST-2 seems able to affect diverse enveloped virions, suggesting a broad role in the host defense against ..
  15. HIV-1 Vpu and BST-2/CD317
    John Guatelli; Fiscal Year: 2009
    ..24, CD317, or "tetherin." BST-2 seems able to affect diverse enveloped virions, suggesting a broad role in the host defense against ..
  16. Molecular Mechanisms of HIV's Immune Evasion
    Kathleen L Collins; Fiscal Year: 2010
    ..This grant proposal aims to more fully understand the viral mechanisms for immune escape and viral persistence in order to eradicate infected cells, cure disease and prevent new infection. ..
  17. HIV-1 Vpu and BST-2/CD317
    John Guatelli; Fiscal Year: 2010
    ..24, CD317, or "tetherin." BST-2 seems able to affect diverse enveloped virions, suggesting a broad role in the host defense against ..
  18. Antiviral Mechanisms of 2-5A Dependent RNase L
    Robert Silverman; Fiscal Year: 2009
    ..The knowledge to be gained may thus lead to strategies for controlling important human viral pathogens. Therefore, there are cogent and health-related justifications for these studies. ..
  19. ANTIVIRAL MECHANISMS OF 2 5A DEPENDENT RNASE
    Robert Silverman; Fiscal Year: 2001
    ..This project may lead to the discovery and development of novel therapeutic agents for viral infections, cancer and other diseases. ..
  20. The MHC-I, HIV-1 Nef, AP-1 Complex
    John Guatelli; Fiscal Year: 2007
    ..The current model is that Nef accomplishes this by linking two components of the host cell, named MHC-I and AP-1, to each other. By understanding the molecular basis of this linkage, new approaches to drug design may become apparent. ..
  21. Antiviral Mechanisms of 2-5A Dependent RNase L
    Robert Silverman; Fiscal Year: 2007
    ..The knowledge to be gained may thus lead to strategies for controlling important human viral pathogens. Therefore, there are cogent and health-related justifications for these studies. ..
  22. Molecular Mechanisms of HIV Disease Pathogenesis
    Kathleen Collins; Fiscal Year: 2007
    ..This proposal is relevant to the mission of NIH in that it seeks to understand basic mechanisms of how HIV establishes a chronic infection. This work has the potential to have a significant impact on public health. ..
  23. Molecular Mechanisms of HIV's Immune Evasion
    Kathleen Collins; Fiscal Year: 2007
    ..Studies are proposed to better understand the detailed molecular mechanism of MHC-I downmodulation. These studies should aid in the development of inhibitors that disrupt HIV immune evasion. ..
  24. HIV 1 NEF AND VIRAL INFECTIVITY
    John Guatelli; Fiscal Year: 2007
    ..We will test the hypothesis that the sorting motifs in both Nef and gp41 are involved in regulated exocytosis, targeting morphogenesis to microdomains of the plasma membrane that render the virion more fusogenic. ..
  25. Single-Cycle SIV as a Novel AIDS Vaccine Approach
    David Evans; Fiscal Year: 2007
    ..Associations between immune responses elicited by scSIV and the outcome of challenge will be analyzed for each specific aim to reveal potential mechanisms of protection. ..
  26. Single-Cycle SIV as a Non-Replicating Vaccine Strain
    David Evans; Fiscal Year: 2004
    ..Macaques immunized with single-cycle viruses will be challenged with wild type SIV by mucosal routes to assess protection. ..
  27. Antiviral Mechanisms of 2 5A Dependent RNase L
    Robert Silverman; Fiscal Year: 2006
    ..Therefore, continuation of this PROJECT is expected to lead to the eventual development of novel strategies for treatment of viral infections and cancer. ..
  28. Role of Phospholipid Scramblase in Interferon Action
    Robert Silverman; Fiscal Year: 2005
    ..abstract_text> ..