BST1

Summary

Gene Symbol: BST1
Description: bone marrow stromal cell antigen 1
Alias: CD157, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2, ADP-ribosyl cyclase 2, NAD(+) nucleosidase, bone marrow stromal antigen 1, cADPr hydrolase 2, cyclic ADP-ribose hydrolase 2
Species: human
Products:     BST1

Top Publications

  1. Kaisho T, Ishikawa J, Oritani K, Inazawa J, Tomizawa H, Muraoka O, et al. BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth. Proc Natl Acad Sci U S A. 1994;91:5325-9 pubmed
  2. Saad M, Lesage S, Saint Pierre A, Corvol J, Zelenika D, Lambert J, et al. Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population. Hum Mol Genet. 2011;20:615-27 pubmed publisher
    ..4 × 10(-7)) and confirmed the association on 4p15/BST1 (rs4698412, combined P = 1.8 × 10(-6)), previously reported in Japanese data...
  3. Satake W, Nakabayashi Y, Mizuta I, Hirota Y, Ito C, Kubo M, et al. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat Genet. 2009;41:1303-7 pubmed publisher
    ..52 x 10(-12)) and designated this as PARK16, and we also identified BST1 on 4p15 as a second new risk locus (P = 3.94 x 10(-9)). We also detected strong associations at SNCA on 4q22 (P = 7...
  4. Zhu L, Luo X, Zhou Y, Li F, Yang Y, Ren Y, et al. Lack of association between three single nucleotide polymorphisms in the PARK9, PARK15, and BST1 genes and Parkinson's disease in the northern Han Chinese population. Chin Med J (Engl). 2012;125:588-92 pubmed
    ..population, we investigated three single nucleotide polymorphisms (SNPs) (rs4538475, rs11107 and rs12564040) in the BST1, PARK15 and PARK9 genes...
  5. Tan E, Kwok H, Kwok H, Tan L, Zhao W, Prakash K, et al. Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus. Neurology. 2010;75:508-12 pubmed publisher
    ..Japanese population identified 2 new Parkinson disease (PD) susceptibility loci on 1q32 (PARK16) (OMIM 613164) and BST1. We analyzed single nucleotide polymorphism (SNPs) located at the GWAS-linked loci (PARK16, PARK8, PARK1, and BST1) ..
  6. Liang F, Qi R, Chang C. Signalling of GPI-anchored CD157 via focal adhesion kinase in MCA102 fibroblasts. FEBS Lett. 2001;506:207-10 pubmed
    b>CD157, a glycosylphosphatidylinositol-anchored protein, has previously been shown to mediate tyrosine phosphorylation of a 130 kDa protein (p130) in several cell lines...
  7. Lavagno L, Ferrero E, Ortolan E, Malavasi F, Funaro A. CD157 is part of a supramolecular complex with CD11b/CD18 on the human neutrophil cell surface. J Biol Regul Homeost Agents. 2007;21:5-11 pubmed
    b>CD157 is a GPI-anchored cell surface glycoprotein expressed by human peripheral blood neutrophils...
  8. Okuyama Y, Ishihara K, Kimura N, Hirata Y, Sato K, Itoh M, et al. Human BST-1 expressed on myeloid cells functions as a receptor molecule. Biochem Biophys Res Commun. 1996;228:838-45 pubmed
    ..These results suggest that BST-1 can deliver signals into cells and function as a receptor. ..
  9. Lo Buono N, Parrotta R, Morone S, Bovino P, Nacci G, Ortolan E, et al. The CD157-integrin partnership controls transendothelial migration and adhesion of human monocytes. J Biol Chem. 2011;286:18681-91 pubmed publisher
    b>CD157, a member of the CD38 gene family, is an NAD-metabolizing ectoenzyme and a signaling molecule whose role in polarization, migration, and diapedesis of human granulocytes has been documented; however, the molecular events ..

More Information

Publications70

  1. Nalls M, Plagnol V, Hernandez D, Sharma M, Sheerin U, Saad M, et al. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet. 2011;377:641-9 pubmed publisher
    ..Six were previously identified loci (MAPT, SNCA, HLA-DRB5, BST1, GAK and LRRK2) and five were newly identified loci (ACMSD, STK39, MCCC1/LAMP3, SYT11, and CCDC62/HIP1R)...
  2. Spencer C, Plagnol V, Strange A, Gardner M, Paisan Ruiz C, Band G, et al. Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet. 2011;20:345-53 pubmed publisher
    ..evidence of association for common variants located in three previously published associated regions (4p15/BST1, 4p16/GAK and 1q32/PARK16). We found no support for the previously reported SNP association in 12q12/LRRK2...
  3. Funaro A, Ortolan E, Ferranti B, Gargiulo L, Notaro R, Luzzatto L, et al. CD157 is an important mediator of neutrophil adhesion and migration. Blood. 2004;104:4269-78 pubmed
    b>CD157, a glycosylphosphatidylinositol (GPI)-anchored protein encoded by a member of the CD38 NADase/ADP-ribosyl cyclase gene family, is expressed on the surface of most human circulating neutrophils...
  4. Chen M, Lin C, Lee M, Wu R. BST1 rs11724635 interacts with environmental factors to increase the risk of Parkinson's disease in a Taiwanese population. Parkinsonism Relat Disord. 2014;20:280-3 pubmed publisher
    ..in Caucasian and Asian populations showed a significant association between the bone marrow stromal cell antigen 1 (BST1) SNP rs11724635 and increased risk for Parkinson's disease (PD)...
  5. Ortolan E, Arisio R, Morone S, Bovino P, Lo Buono N, Nacci G, et al. Functional role and prognostic significance of CD157 in ovarian carcinoma. J Natl Cancer Inst. 2010;102:1160-77 pubmed publisher
    b>CD157, an ADP-ribosyl cyclase-related cell surface molecule, regulates leukocyte diapedesis during inflammation...
  6. Simon Sanchez J, Van Hilten J, van de Warrenburg B, Post B, Berendse H, Arepalli S, et al. Genome-wide association study confirms extant PD risk loci among the Dutch. Eur J Hum Genet. 2011;19:655-61 pubmed publisher
    ..Direct replication of SNPs within SNCA and BST1 confirmed these two genes to be associated with PD in the Netherlands (SNCA, rs2736990: P = 1.63 × 10(-5), OR = 1...
  7. Suenaga F, Ueha S, Abe J, Kosugi Kanaya M, Wang Y, Yokoyama A, et al. Loss of lymph node fibroblastic reticular cells and high endothelial cells is associated with humoral immunodeficiency in mouse graft-versus-host disease. J Immunol. 2015;194:398-406 pubmed publisher
    ..These humoral immune defects were associated with the early loss of fibroblastic reticular cells, most notably the CD157(+) cell subset, as well as structural defects in high endothelial venules...
  8. Guo J, Li K, Yu R, Sun Q, Wang L, Yao L, et al. Polygenic determinants of Parkinson's disease in a Chinese population. Neurobiol Aging. 2015;36:1765.e1-1765.e6 pubmed publisher
    ..Sixteen SNPs located in the 8 genes and/or loci (SNCA, LRRK2, MAPT, GBA, HLA-DR, BST1, PARK16, and PARK17) were analyzed in a Chinese cohort consisting of 1061 well-characterized PD patients and 1066 ..
  9. Sharma M, Ioannidis J, Aasly J, Annesi G, Brice A, Van Broeckhoven C, et al. Large-scale replication and heterogeneity in Parkinson disease genetic loci. Neurology. 2012;79:659-67 pubmed publisher
    ..78-0.87 (LAMP3, BST1, and MAPT) and susceptibility per-allele odds ratios of 1.14-1.43 (STK39, GAK, SNCA, LRRK2, SYT11, and HIP1R)...
  10. Lill C, Roehr J, McQueen M, Kavvoura F, Bagade S, Schjeide B, et al. Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet. 2012;8:e1002548 pubmed publisher
    ..Eleven loci showed genome-wide significant (P < 5 × 10(-8)) association with disease risk: BST1, CCDC62/HIP1R, DGKQ/GAK, GBA, LRRK2, MAPT, MCCC1/LAMP3, PARK16, SNCA, STK39, and SYT11/RAB25...
  11. Sutherland D, Illingworth A, Keeney M, Richards S. High-Sensitivity Detection of PNH Red Blood Cells, Red Cell Precursors, and White Blood Cells. Curr Protoc Cytom. 2015;72:6.37.1-30 pubmed publisher
    ..01% and 0.04% sensitivity, respectively. For instrumentation with five or more PMTs, a single-tube 5-color FLAER/CD157-based assay to simultaneously detect PNH neutrophils and monocytes is described...
  12. Mizuno A, Cherepanov S, Kikuchi Y, Fakhrul A, Akther S, Deguchi K, et al. Lipo-oxytocin-1, a Novel Oxytocin Analog Conjugated with Two Palmitoyl Groups, Has Long-Lasting Effects on Anxiety-Related Behavior and Social Avoidance in CD157 Knockout Mice. Brain Sci. 2015;5:3-13 pubmed publisher
    ..To determine whether LOT-1 actually has an effect on the central nervous system, we examined its effects in a CD157 knockout model mouse of the non-motor psychiatric symptoms of Parkinson's disease...
  13. Jensen C, Åhsberg J, Sommarin M, Strid T, Somasundaram R, Okuyama K, et al. Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis. J Exp Med. 2018;215:1947-1963 pubmed publisher
    ..to link surface marker expression to that of lineage-associated transcription factors (TFs) and identify GFRA2 and BST1 as markers of early B cells...
  14. Ortolan E, Augeri S, Fissolo G, Musso I, Funaro A. CD157: From immunoregulatory protein to potential therapeutic target. Immunol Lett. 2019;205:59-64 pubmed publisher
    b>CD157/BST1 glycosylphosphatidylinositol-anchored glycoprotein is an evolutionary conserved dual-function receptor and β-NAD+-metabolizing ectoenzyme of the ADP-ribosyl cyclases gene family...
  15. Ferrero E, Faini A, Malavasi F. A phylogenetic view of the leukocyte ectonucleotidases. Immunol Lett. 2019;205:51-58 pubmed publisher
    ..related small molecules is their breakdown on behalf of a panel of leukocyte ectonucleotidases - CD38, CD39, CD73, CD157, CD203a and CD203c -, whose activities are concatenated to form two nucleotide-catabolizing channels defined as ..
  16. Malavasi F, Deaglio S, Ferrero E, Funaro A, Sancho J, Ausiello C, et al. CD38 and CD157 as receptors of the immune system: a bridge between innate and adaptive immunity. Mol Med. 2006;12:334-41 pubmed
    ..of the results and the speculations presented at the Torino CD38 Meeting in June, 2006 and focused on CD38 and CD157 seen as a family of molecules acting as surface receptors of immune cells...
  17. Totten S, Adusumilli R, Kullolli M, Tanimoto C, Brooks J, Mallick P, et al. Multi-lectin Affinity Chromatography and Quantitative Proteomic Analysis Reveal Differential Glycoform Levels between Prostate Cancer and Benign Prostatic Hyperplasia Sera. Sci Rep. 2018;8:6509 pubmed publisher
    ..Global levels of CD5L, CFP, C8A, BST1, and C7 were significantly increased in the PCa samples...
  18. Higashida H, Liang M, Yoshihara T, Akther S, Fakhrul A, Stanislav C, et al. An immunohistochemical, enzymatic, and behavioral study of CD157/BST-1 as a neuroregulator. BMC Neurosci. 2017;18:35 pubmed publisher
    Recent rodent and human studies provide evidence in support of the fact that CD157, well known as bone marrow stromal cell antigen-1 (BST-1) and a risk factor in Parkinson's disease, also meaningfully acts in the brain as a ..
  19. Morandi F, Horenstein A, Chillemi A, Quarona V, Chiesa S, Imperatori A, et al. CD56brightCD16- NK Cells Produce Adenosine through a CD38-Mediated Pathway and Act as Regulatory Cells Inhibiting Autologous CD4+ T Cell Proliferation. J Immunol. 2015;195:965-72 pubmed publisher
    ..CD39, CD73, and CD157 expression was higher in CD56(bright)CD16(-) than in CD56(dim)CD16(+) NK cells...
  20. Zhang Y, Tech L, George L, Acs A, Durrett R, Hess H, et al. Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells. J Exp Med. 2018;215:1227-1243 pubmed publisher
    ..of plasmablasts from the GC, and TNFSF13 (APRIL), which is produced by a population of podoplanin+ CD157high fibroblastic reticular cells located in the GTI that are also rich in message for IL-6 and ..
  21. Zhang J, Cheng Y, Duan M, Qi N, Liu J. Unveiling differentially expressed genes upon regulation of transcription factors in sepsis. 3 Biotech. 2017;7:46 pubmed publisher
    ..ten upregulated DEGs (S100A8, S100A9, S100A12, PGLYRP1 and MMP9) and three downregulated DEGs (ZNF84, CYB561A3 and BST1) were under the regulation of three hub TFs of Pax-4, POU2F1, and Nkx2-5...
  22. Inoue M, Yamada J, Aomatsu Kikuchi E, Satoh K, Kondo H, Ishisaki A, et al. SCRG1 suppresses LPS-induced CCL22 production through ERK1/2 activation in mouse macrophage Raw264.7 cells. Mol Med Rep. 2017;15:4069-4076 pubmed publisher
    ..gene 1 (SCRG1) secreted from mesenchymal stem cells (MSCs) and its receptor bone marrow stromal cell antigen 1 (BST1) as positive regulators of stem cell qualities such as self‑renewal, migration abilities, and osteogenic ..
  23. Yokoyama S, Al Mahmuda N, Munesue T, Hayashi K, Yagi K, Yamagishi M, et al. Association Study between the CD157/BST1 Gene and Autism Spectrum Disorders in a Japanese Population. Brain Sci. 2015;5:188-200 pubmed publisher
    b>CD157, also referred to as bone marrow stromal cell antigen-1 (BST-1), is a glycosylphosphatidylinositol-anchored molecule that promotes pre-B-cell growth...
  24. Wakabayashi T, Naito H, Suehiro J, Lin Y, Kawaji H, Iba T, et al. CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties. Cell Stem Cell. 2018;22:384-397.e6 pubmed publisher
    ..A role for adult stem cells in this process remains unclear. Here, we identified CD157 (bst1, bone marrow stromal antigen 1) as a marker of tissue-resident vascular endothelial stem cells (VESCs) in large arteries and veins of ..
  25. Zhu X, Cao L, Tan M, Jiang T, Wang H, Lu H, et al. Association of Parkinson's Disease GWAS-Linked Loci with Alzheimer's Disease in Han Chinese. Mol Neurobiol. 2017;54:308-318 pubmed publisher
    ..between late-onset AD (LOAD) susceptibility and nine single-nucleotide polymorphisms (SNPs) (rs11724635 of BST1, rs12637471 of MCCC1, rs15553999 of TMEM229, rs17649553 of MAPT, rs34311866 of TMEM175-GAK-DGKQ, rs356182 of SNCA, ..
  26. Blaha J, Schwarz K, Fischer C, Schauwecker P, Höchsmann B, Schrezenmeier H, et al. The Monoclonal Anti-CD157 Antibody Clone SY11B5, Used for High Sensitivity Detection of PNH Clones on WBCs, Fails to Detect a Common Polymorphic Variant Encoded by BST-1. Cytometry B Clin Cytom. 2018;94:652-659 pubmed publisher
    b>CD157, encoded by BST-1, has been described as a useful flow cytometric marker for the analysis of paroxysmal nocturnal hemoglobinuria (PNH) as it is a glycosylphosphatidylinositol (GPI)-linked molecule highly expressed on normal ..
  27. Marinov I, Illingworth A, Benko M, Sutherland D. Performance Characteristics of a Non-Fluorescent Aerolysin-Based Paroxysmal Nocturnal Hemoglobinuria (PNH) Assay for Simultaneous Evaluation of PNH Neutrophils and PNH Monocytes by Flow Cytometry, Following Published PNH Guidelines. Cytometry B Clin Cytom. 2018;94:257-263 pubmed publisher
    b>CD157 has been recently reported as a useful glycosylphosphatidylinositol (GPI)-linked marker for the detection of paroxysmal nocturnal hemoglobinuria (PNH) clones in patients with suspected paroxysmal nocturnal hemoglobinuria by flow ..
  28. Carulli G, Marini A, Sammuri P, Domenichini C, Ottaviano V, Pacini S, et al. Combination of CD157 and FLAER to Detect Peripheral Blood Eosinophils by Multiparameter Flow Cytometry. J Clin Exp Hematop. 2015;55:55-60 pubmed publisher
    ..The combination of CD157 and FLAER was used, since FLAER recognizes all GPI-linked molecules, while CD157 is absent on the membrane of ..
  29. Cacan E. Epigenetic-mediated immune suppression of positive co-stimulatory molecules in chemoresistant ovarian cancer cells. Cell Biol Int. 2017;41:328-339 pubmed publisher
    ..4-1BB ligand (4-1BBL/CD157) and OX-40 ligand (OX-40L/CD252) are important regulators of effector cytotoxic T-cells activity...
  30. Chang K, Wu Y, Chen Y, Fung H, Lee Chen G, Chen C. STK39, But Not BST1, HLA-DQB1, and SPPL2B Polymorphism, Is Associated With Han-Chinese Parkinson's Disease in Taiwan. Medicine (Baltimore). 2015;94:e1690 pubmed publisher
    ..org/top_results), including serine threonine kinase 39 (STK39) rs1955337, bone marrow stromal cell antigen 1 (BST1) rs11724635, major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1) rs9275326, and signal peptide ..
  31. Borg N, Alter C, Görldt N, Jacoby C, Ding Z, Steckel B, et al. CD73 on T Cells Orchestrates Cardiac Wound Healing After Myocardial Infarction by Purinergic Metabolic Reprogramming. Circulation. 2017;136:297-313 pubmed publisher
    ..equilibrative nucleoside transporter 1, CD39, CD73, ecto-nucleotide pyrophosphatase/phosphodiesterases 1 and 3, CD157, CD38) for the accelerated release and hydrolysis of ATP, cAMP, AMP, and NAD to adenosine...
  32. Harlan B, Pehar M, Sharma D, Beeson G, Beeson C, Vargas M. Enhancing NAD+ Salvage Pathway Reverts the Toxicity of Primary Astrocytes Expressing Amyotrophic Lateral Sclerosis-linked Mutant Superoxide Dismutase 1 (SOD1). J Biol Chem. 2016;291:10836-46 pubmed publisher
    ..families of enzymes consume NAD(+) as substrate: poly(ADP-ribose) polymerases, ADP-ribosyl cyclases (CD38 and CD157), and sirtuins (SIRT1-7)...
  33. Ferrero E, Lo Buono N, Horenstein A, Funaro A, Malavasi F. The ADP-ribosyl cyclases--the current evolutionary state of the ARCs. Front Biosci (Landmark Ed). 2014;19:986-1002 pubmed
    ..Here we present a phylogenetic view of the ARCs to better understand the evolution of function in this family. ..
  34. Ceroni F, Sagar A, Simpson N, Gawthrope A, Newbury D, Pinto D, et al. A deletion involving CD38 and BST1 results in a fusion transcript in a patient with autism and asthma. Autism Res. 2014;7:254-63 pubmed publisher
    ..The younger sister, who also had asthma, inherited a maternal deletion of 4p15.32 that results in a BST1-CD38 fusion transcript. Their mother's deletion was mosaic and she was not affected...
  35. Yamamoto Katayama S, Sato A, Ariyoshi M, Suyama M, Ishihara K, Hirano T, et al. Site-directed removal of N-glycosylation sites in BST-1/CD157: effects on molecular and functional heterogeneity. Biochem J. 2001;357:385-92 pubmed
    ..cyclase function is found in two membrane proteins, CD38 and bone marrow stromal cell antigen 1 (BST-1)/CD157. These enzymes are exposed extracellularly and also possess cADPR hydrolase activity, but an intracellular soluble ..
  36. Morone S, Augeri S, Cuccioloni M, Mozzicafreddo M, Angeletti M, Lo Buono N, et al. Binding of CD157 protein to fibronectin regulates cell adhesion and spreading. J Biol Chem. 2014;289:15588-601 pubmed publisher
    b>CD157/BST-1 behaves both as an ectoenzyme and signaling receptor and is an important regulator of leukocyte trafficking and ovarian cancer progression...
  37. Kajimoto Y, Miyagawa J, Ishihara K, Okuyama Y, Fujitani Y, Itoh M, et al. Pancreatic islet cells express BST-1, a CD38-like surface molecule having ADP-ribosyl cyclase activity. Biochem Biophys Res Commun. 1996;219:941-6 pubmed
    ..These observations suggest the involvement of multiple enzymes in the regulation of cADPR concentrations in pancreatic islet cells. ..
  38. Lopatina O, Yoshihara T, Nishimura T, Zhong J, Akther S, Fakhrul A, et al. Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease. Front Behav Neurosci. 2014;8:133 pubmed publisher
    b>CD157, known as bone marrow stromal cell antigen-1, is a glycosylphosphatidylinositol-anchored ADP-ribosyl cyclase that supports the survival and function of B-lymphocytes and hematopoietic or intestinal stem cells...
  39. Wimazal F, Ghannadan M, Muller M, End A, Willheim M, Meidlinger P, et al. Expression of homing receptors and related molecules on human mast cells and basophils: a comparative analysis using multi-color flow cytometry and toluidine blue/immunofluorescence staining techniques. Tissue Antigens. 1999;54:499-507 pubmed
    ..matrix-receptor' neurothelin (CD147), platelet-endothelial cell tetraspan antigen-3 (PETA-3=CD151), and BST-1 (CD157). Novel antigens detectable on MC (lung and uterus) were CD147, CD151, CD157 and CD49c (VLA-3alpha)...
  40. Muraoka O, Tanaka H, Itoh M, Ishihara K, Hirano T. Genomic structure of human BST-1. Immunol Lett. 1996;54:1-4 pubmed
    ..The flanking region of the BST-1 gene contained several potential binding sites for nuclear factors, NF-kappa B, p53, NF-IL6, CREB, PEA3, E2A, C/EBP, AP3, AP2 and SP1 and consensus sequences for gamma-IRE and ISRE like element. ..
  41. Ortolan E, Vacca P, Capobianco A, Armando E, Crivellin F, Horenstein A, et al. CD157, the Janus of CD38 but with a unique personality. Cell Biochem Funct. 2002;20:309-22 pubmed
    b>CD157 is a pleiotropic ectoenzyme which belongs to the CD38 family and to the growing number of leukocyte surface molecules known to act independently as both receptors and enzymes...
  42. Wang C, Feng X, Xie S, Gu Z, Chan P. Exonic sequencing revealed no causative mutation in the BST1 gene in patients with Parkinson's disease. Neurobiol Aging. 2013;34:2695.e9-2695.e10 pubmed publisher
    ..Parkinson's disease (PD) to a locus on 4p15 encompassing a single gene encoding bone marrow stromal cell antigen 1 (BST1)...
  43. Miyake Y, Tanaka K, Fukushima W, Kiyohara C, Sasaki S, Tsuboi Y, et al. Lack of association between BST1 polymorphisms and sporadic Parkinson's disease in a Japanese population. J Neurol Sci. 2012;323:162-6 pubmed publisher
    ..and case-control studies have investigated the relationships between single nucleotide polymorphisms (SNPs) in the BST1 gene and Parkinson's disease (PD), but the results have been inconsistent...
  44. Ferrero E, Lo Buono N, Morone S, Parrotta R, Mancini C, Brusco A, et al. Human canonical CD157/Bst1 is an alternatively spliced isoform masking a previously unidentified primate-specific exon included in a novel transcript. Sci Rep. 2017;7:15923 pubmed publisher
    b>CD157/Bst1 is a dual-function receptor and ?-NAD+-metabolizing ectoenzyme of the ADP-ribosyl cyclase family...
  45. Wang S, Xu Y, Ding X, Liu Z, Ding Y, Jin B, et al. Association between bone marrow stromal cell antigen 1 gene polymorphisms and the susceptibility to Parkinson's disease: a meta-analysis. Neurosci Lett. 2015;599:120-4 pubmed publisher
    ..08-1.31; P=0.001). Sensitivity analysis supported these findings, and no evidence of publication bias was observed in the meta-analysis. Our studies suggested that the rs4698412 variant of BST-1 may increase the PD susceptibility. ..
  46. Aomatsu E, Takahashi N, Sawada S, Okubo N, Hasegawa T, Taira M, et al. Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells. Sci Rep. 2014;4:3652 pubmed publisher
    ..Here, we identified the hMSC-secreted protein SCRG1 and its receptor BST1 as a positive regulator of self-renewal, migration, and osteogenic differentiation...
  47. Lee B, Ishihara K, Denno K, Kobune Y, Itoh M, Muraoka O, et al. Elevated levels of the soluble form of bone marrow stromal cell antigen 1 in the sera of patients with severe rheumatoid arthritis. Arthritis Rheum. 1996;39:629-37 pubmed
    ..We believe the measurement of serum sBST-1 may have prognostic value, but further analysis is necessary to clarify the clinical significance of elevated sBST-1 in RA. ..
  48. Ruan Q, Ruan J, Zhang W, Qian F, Yu Z. Targeting NAD+ degradation: The therapeutic potential of flavonoids for Alzheimer's disease and cognitive frailty. Pharmacol Res. 2018;128:345-358 pubmed publisher
    ..were shown to inhibit poly (ADP-ribose) polymerases (PARPs) and cyclic ADP-ribose (cADP) synthases (CD38 and CD157), elevate intracellular nicotinamide adenine dinucleotide+ (NAD+) levels and activate NAD<..
  49. Foo J, Tan L, Irwan I, Au W, Low H, Prakash K, et al. Genome-wide association study of Parkinson's disease in East Asians. Hum Mol Genet. 2017;26:226-232 pubmed publisher
    ..DLG2, SIPA1L2, STK39, VPS13C and RIT2), and observed the same direction of associations at 9 other loci including BST1 and PARK16...
  50. Quarona V, Zaccarello G, Chillemi A, Brunetti E, Singh V, Ferrero E, et al. CD38 and CD157: a long journey from activation markers to multifunctional molecules. Cytometry B Clin Cytom. 2013;84:207-17 pubmed publisher
    ..CD38 and its homologue CD157 (BST-1), contiguous gene duplicates on human chromosome 4 (4p15), are part of a gene family encoding products that ..
  51. Morone S, Lo Buono N, Parrotta R, Giacomino A, Nacci G, Brusco A, et al. Overexpression of CD157 contributes to epithelial ovarian cancer progression by promoting mesenchymal differentiation. PLoS ONE. 2012;7:e43649 pubmed publisher
    ..Recently, we reported that CD157 (an ectoenzyme regulating leukocyte diapedesis) is expressed in EOC and that high expression of the molecule is ..
  52. Mo W, Liu J, Zhang Z, Yu H, Yang A, Qu F, et al. A study of single nucleotide polymorphisms in CD157, AIM2 and JARID2 genes in Han Chinese children with autism spectrum disorder. Nord J Psychiatry. 2017;:1-5 pubmed publisher
    ..The objective of this study was to investigate whether single nucleotide polymorphisms (SNPs) in genes related to immune function were associated with ASD in Chinese Han children...
  53. Hamza T, Zabetian C, Tenesa A, Laederach A, Montimurro J, Yearout D, et al. Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. Nat Genet. 2010;42:781-5 pubmed publisher
    ..The genetic association with HLA supports the involvement of the immune system in Parkinson's disease and offers new targets for drug development. ..
  54. Pankratz N, Beecham G, Destefano A, Dawson T, Doheny K, Factor S, et al. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. Ann Neurol. 2012;71:370-84 pubmed publisher
    ..We identified a novel PD susceptibility locus, RIT2, replicated several previously identified loci, and identified more than 1 risk allele within SNCA and GBA. ..
  55. Liu J, Xiao Q, Xu Z, Wang Y, Yang Q, Wang G, et al. Analysis of genome-wide association study-linked loci in Parkinson's disease of Mainland China. Mov Disord. 2013;28:1892-5 pubmed publisher
    ..This study yields new clues about GWAS-linked data in patients with PD from Mainland China. ..
  56. Yamamoto Katayama S, Ariyoshi M, Ishihara K, Hirano T, Jingami H, Morikawa K. Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities. J Mol Biol. 2002;316:711-23 pubmed
    ..In mammals, the ADP-ribosyl cyclase function is found in two membrane proteins, CD38 and BST-1/CD157. These enzymes, exposed extracellularly, bear cADPR hydrolase and NAD glycohydrolase activities...
  57. Hirata Y, Kimura N, Sato K, Ohsugi Y, Takasawa S, Okamoto H, et al. ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1. FEBS Lett. 1994;356:244-8 pubmed
    ..Here, we report the establishment of a stable transformant CHO cell line, which secretes truncated human soluble BST-1, and show that purified soluble BST-1 displays both ADP ribosyl cyclase and cADPR hydrolase activities. ..
  58. Chong A, Malavasi F, Israel S, Khor C, Yap V, Monakhov M, et al. ADP ribosyl-cyclases (CD38/CD157), social skills and friendship. Psychoneuroendocrinology. 2017;78:185-192 pubmed publisher
    ..Second, three CD157 eQTL SNPs in the CD38/CD157 gene region were associated with CD38 expression...
  59. Horenstein A, Sizzano F, Lusso R, Besso F, Ferrero E, Deaglio S, et al. CD38 and CD157 ectoenzymes mark cell subsets in the human corneal limbus. Mol Med. 2009;15:76-84 pubmed publisher
    ..This study investigates the expression in the human cornea of CD38 and CD157, two NAD(+)-consuming ectoenzymes and surface receptors...
  60. Preugschat F, Carter L, Boros E, Porter D, Stewart E, Shewchuk L. A pre-steady state and steady state kinetic analysis of the N-ribosyl hydrolase activity of hCD157. Arch Biochem Biophys. 2014;564:156-63 pubmed publisher
    ..This comparison identified several residues in hCD157 (F108 and F173) that can potentially hinder the binding of dinucleotide substrates (NAD+). ..
  61. Chung S, Jung Y, Hong M, Kim M, You S, Kim Y, et al. Alzheimer's disease and Parkinson's disease genome-wide association study top hits and risk of Parkinson's disease in Korean population. Neurobiol Aging. 2013;34:2695.e1-7 pubmed publisher
    ..We selected 25 single nucleotide polymorphisms (SNPs) in 9 genes (ABCA7, APOE, BST1, CLU, CR1, LRRK2, PARK16, PICALM, and SNCA) that were genotyped in 1036 PD case patients and 1208 controls...