BRM

Summary

Gene Symbol: BRM
Description: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Alias: BAF190, BRM, NCBRS, SNF2, SNF2L2, SNF2LA, SWI2, Sth1p, hBRM, hSNF2a, ATP-dependent helicase SMARCA2, BAF190B, BRG1-associated factor 190B, SNF2-alpha, SNF2/SWI2-like protein 2, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2, brahma homolog, global transcription activator homologous sequence, protein brahma homolog, sucrose nonfermenting 2-like protein 2
Species: human
Products:     BRM

Top Publications

  1. Glaros S, Cirrincione G, Muchardt C, Kleer C, Michael C, Reisman D. The reversible epigenetic silencing of BRM: implications for clinical targeted therapy. Oncogene. 2007;26:7058-66 pubmed
    ..SWI/SNF function requires one of two paralogous ATPase subunits, Brahma (BRM) or BRM-related gene 1 (BRG1), which we previously found are lost together in cancer cell lines and primary lung ..
  2. Kowenz Leutz E, Leutz A. A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes. Mol Cell. 1999;4:735-43 pubmed
    ..Interaction between C/EBP beta and SWI/SNF is essential for activating a subgroup of resident target genes in chromatin and may represent a major determinant of combinatorial gene regulation in eukaryotes. ..
  3. Gunduz E, Gunduz M, Ali M, Beder L, Tamamura R, Katase N, et al. Loss of heterozygosity at the 9p21-24 region and identification of BRM as a candidate tumor suppressor gene in head and neck squamous cell carcinoma. Cancer Invest. 2009;27:661-8 pubmed publisher
    ..However, novel frequent chromosomal deletion and a candidate tumor suppressor gene, BRM at the 9p24 region, were detected...
  4. Matsubara D, Kishaba Y, Ishikawa S, Sakatani T, Oguni S, Tamura T, et al. Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features. Cancer Sci. 2013;104:266-73 pubmed publisher
    BRG1 and BRM, two core catalytic subunits in SWI/SNF chromatin remodeling complexes, have been suggested as tumor suppressors, yet their roles in carcinogenesis are unclear...
  5. Gao X, Huang M, Liu L, He Y, Yu Q, Zhao H, et al. Insertion/deletion polymorphisms in the promoter region of BRM contribute to risk of hepatocellular carcinoma in Chinese populations. PLoS ONE. 2013;8:e55169 pubmed publisher
    b>BRM (Brahma homologue) is well known for its critical role in tumor suppression and cancer development...
  6. Wang W, Cote J, Xue Y, Zhou S, Khavari P, Biggar S, et al. Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. EMBO J. 1996;15:5370-82 pubmed
    ..proteins [referred to as BRG1-associated factors (BAFs)] from several mammalian cell lines using an antibody to the SWI2-SNF2 homolog BRG1. Microsequencing revealed that the 47 kDa BAF is identical to INI1...
  7. Sif S, Stukenberg P, Kirschner M, Kingston R. Mitotic inactivation of a human SWI/SNF chromatin remodeling complex. Genes Dev. 1998;12:2842-51 pubmed
    ..Brg1 and hBrm, which are components of human SWI/SNF (hSWI/SNF) complexes, were recently shown to be phosphorylated during ..
  8. Ito T, Watanabe H, Yamamichi N, Kondo S, Tando T, Haraguchi T, et al. Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts in concert with p54(nrb). Biochem J. 2008;411:201-9 pubmed
    ..a DBHS (Drosophila behaviour, human splicing) family protein, p54(nrb), binds both BRG1 (Brahma-related gene 1) and Brm (Brahma), catalytic subunits of the SWI/SNF (switch/sucrose non-fermentable) chromatin remodelling complex, and ..
  9. Wang F, Zhang R, Beischlag T, Muchardt C, Yaniv M, Hankinson O. Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene. J Biol Chem. 2004;279:46733-41 pubmed
    ..We demonstrate that Brahma (Brm) and Brahma/SWI2-related gene 1 (Brg-1), alternative ATPase subunits of SWI/SNF, potentiate reporter gene activation mediated by HIF-..

More Information

Publications83

  1. Hoffman G, Rahal R, Buxton F, Xiang K, McAllister G, Frias E, et al. Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers. Proc Natl Acad Sci U S A. 2014;111:3128-33 pubmed publisher
    ..This screen identified BRM/SMARCA2, a DNA-dependent ATPase of the mammalian SWI/SNF (mSWI/SNF) chromatin remodeling complex, as being ..
  2. Wang W, Xue Y, Zhou S, Kuo A, Cairns B, Crabtree G. Diversity and specialization of mammalian SWI/SNF complexes. Genes Dev. 1996;10:2117-30 pubmed
    ..The observed similarity between mammalian BAF190, BAF170, BAF155, BAF60, and BAF47 and yeast SNF2/SWI2, SWI3, SWI3, SWP73, and SNF5, respectively, underscores the ..
  3. Sakurai K, Furukawa C, Haraguchi T, Inada K, Shiogama K, Tagawa T, et al. MicroRNAs miR-199a-5p and -3p target the Brm subunit of SWI/SNF to generate a double-negative feedback loop in a variety of human cancers. Cancer Res. 2011;71:1680-9 pubmed publisher
    The chromatin remodeling complex SWI/SNF is an important epigenetic regulator that includes one Brm or BRG1 molecule as catalytic subunit...
  4. Yamamichi N, Inada K, Ichinose M, Yamamichi Nishina M, Mizutani T, Watanabe H, et al. Frequent loss of Brm expression in gastric cancer correlates with histologic features and differentiation state. Cancer Res. 2007;67:10727-35 pubmed
    The mammalian SWI/SNF chromatin remodeling complex, an essential epigenetic regulator, contains either a single Brm or BRG1 molecule as its catalytic subunit...
  5. Inoue H, Furukawa T, Giannakopoulos S, Zhou S, King D, Tanese N. Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors. J Biol Chem. 2002;277:41674-85 pubmed
    ..Co-precipitation studies indicate that hOsa1 and hOsa2 associate with BRG1 and hBRM through the C-terminal domain of hOsa...
  6. Batsche E, Yaniv M, Muchardt C. The human SWI/SNF subunit Brm is a regulator of alternative splicing. Nat Struct Mol Biol. 2006;13:22-9 pubmed
    ..Here we show that SWI/SNF can function as a regulator of alternative splicing. We found that the catalytic subunit Brm favors inclusion of variant exons in the mRNA of several genes, including E-cadherin, BIM, cyclin D1 and CD44...
  7. Koga M, Ishiguro H, Yazaki S, Horiuchi Y, Arai M, Niizato K, et al. Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia. Hum Mol Genet. 2009;18:2483-94 pubmed publisher
    ..The SMARCA2 gene encodes BRM in the SWI/SNF chromatin-remodeling complex, and associations of single nucleotide polymorphisms (SNPs) to ..
  8. Machida Y, Murai K, Miyake K, Iijima S. Expression of chromatin remodeling factors during neural differentiation. J Biochem. 2001;129:43-9 pubmed
    ..One of the key subunits of this complex, called SWI2/SNF2, has a DNA-dependent ATPase activity...
  9. Mizutani T, Ito T, Nishina M, Yamamichi N, Watanabe A, Iba H. Maintenance of integrated proviral gene expression requires Brm, a catalytic subunit of SWI/SNF complex. J Biol Chem. 2002;277:15859-64 pubmed
    ..retrovirus vector transgene expression is rapidly silenced in human tumor cell lines lacking expression of Brm, a catalytic subunit of the SWI/SNF chromatin remodeling complex, even though these vectors can successfully enter, ..
  10. Chiba H, Muramatsu M, Nomoto A, Kato H. Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor. Nucleic Acids Res. 1994;22:1815-20 pubmed
    A set of genes (SWI1, SWI2/SNF2, SWI3, SNF5 and SNF6) in Saccharomyces cerevisiae are required for transcription of a variety of yeast genes...
  11. Phelan M, Sif S, Narlikar G, Kingston R. Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. Mol Cell. 1999;3:247-53 pubmed
    ..Unexpectedly, both BRG1 and hBRM, the ATPase subunits of human SWI/SNF complexes, are capable of remodeling mono-nucleosomes and nucleosomal arrays ..
  12. Fukuoka J, Fujii T, Shih J, Dracheva T, Meerzaman D, Player A, et al. Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer. Clin Cancer Res. 2004;10:4314-24 pubmed
    ..Nuclear signals of BRM, Ini-1, retinoblastoma, mSin3A, HDAC1, and HAT1 clustered together, whereas nuclear signals of BRG1, BAF155, HDAC2, ..
  13. Treand C, du Chéné I, Brès V, Kiernan R, Benarous R, Benkirane M, et al. Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter. EMBO J. 2006;25:1690-9 pubmed
    ..Here, we reported that Tat interacts directly with Brm, a DNA-dependent ATPase subunit of the SWI/SNF chromatin-remodeling complex, to activate the HIV-1 LTR...
  14. Muchardt C, Yaniv M. A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor. EMBO J. 1993;12:4279-90 pubmed
    ..One of these proteins, SNF2/SWI2, has a homologue in Drosophila, a regulator of homeotic genes known as brahma or brm...
  15. Wang J, Gramling S, Goldstein D, Cheng D, Chen D, Azad A, et al. Association of two BRM promoter polymorphisms with head and neck squamous cell carcinoma risk. Carcinogenesis. 2013;34:1012-7 pubmed publisher
    ..Expression of Brahma (BRM), a critical catalytic subunit of SWI/SNF, is lost in a variety of solid tumors...
  16. Kadam S, Emerson B. Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes. Mol Cell. 2003;11:377-89 pubmed
    ..Each complex contains one of two highly homologous ATPases, BRG1 and BRM, yet little is known about their specialized functions...
  17. Xu Y, Zhang J, Chen X. The activity of p53 is differentially regulated by Brm- and Brg1-containing SWI/SNF chromatin remodeling complexes. J Biol Chem. 2007;282:37429-35 pubmed
    Brahma (Brm) and Brahma-related gene-1 (Brg1) ATPases share similarities in structure and function, but their presence in human SWI/SNF chromatin remodeling complexes is mutually exclusive...
  18. Ishizaka A, Mizutani T, Kobayashi K, Tando T, Sakurai K, Fujiwara T, et al. Double plant homeodomain (PHD) finger proteins DPF3a and -3b are required as transcriptional co-activators in SWI/SNF complex-dependent activation of NF-?B RelA/p50 heterodimer. J Biol Chem. 2012;287:11924-33 pubmed publisher
    ..In conclusion, our present data indicate that by linking RelA/p50 to the SWI/SNF complex, DPF3a/b induces the transactivation of NF-?B target gene promoters in relatively inactive chromatin contexts. ..
  19. Flowers S, Nagl N, Beck G, Moran E. Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation. J Biol Chem. 2009;284:10067-75 pubmed publisher
    ..The catalytic core of the complex can be either of two closely related ATPases, BRM or BRG1, with the potential that the choice of alternative subunits is a key determinant of specificity...
  20. Yamamichi Nishina M, Ito T, Mizutani T, Yamamichi N, Watanabe H, Iba H. SW13 cells can transition between two distinct subtypes by switching expression of BRG1 and Brm genes at the post-transcriptional level. J Biol Chem. 2003;278:7422-30 pubmed
    The human adrenal carcinoma cell line, SW13, has been reported to be deficient in both BRG1 and Brm expression and therefore is considered to lack a functional SWI/SNF complex...
  21. Reisman D, Sciarrotta J, Wang W, Funkhouser W, Weissman B. Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis. Cancer Res. 2003;63:560-6 pubmed
    ..In addition, Western blot data have shown that the SWI/SNF ATPase subunits cell, BRG1 and BRM (BRG1/BRM), are lost in approximately 30% of human non-small lung cancer cell lines...
  22. Park J, Park E, Lee H, Kim S, Hur S, Imbalzano A, et al. Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction. EMBO J. 2006;25:3986-97 pubmed
    ..Given the crucial role for gamma-H2AX in efficient DSB repair, these results suggest that the SWI/SNF complexes facilitate DSB repair, at least in part, by promoting H2AX phosphorylation by directly acting on chromatin. ..
  23. Muchardt C, Reyes J, Bourachot B, Leguoy E, Yaniv M. The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis. EMBO J. 1996;15:3394-402 pubmed
    ..At the present time, three human homologues of yeast SNF/SWI proteins have been characterized: hbrm and BRG-1, homologues of SNF2/SWI2, and hSNF5, a homologue of SNF5...
  24. Wang S, Zhang B, Faller D. Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth. EMBO J. 2002;21:3019-28 pubmed
    ..We show here that prohibitin recruits Brg-1/Brm to E2F-responsive promoters, and that this recruitment is required for the repression of E2F-mediated transcription ..
  25. Tando T, Ishizaka A, Watanabe H, Ito T, Iida S, Haraguchi T, et al. Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway. J Biol Chem. 2010;285:21951-60 pubmed publisher
    ..REQ, together with Brm, a catalytic subunit of the SWI/SNF complex, enhances the NF-kappaB-dependent transcriptional activation that ..
  26. Strobeck M, Reisman D, Gunawardena R, Betz B, Angus S, Knudsen K, et al. Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling. J Biol Chem. 2002;277:4782-9 pubmed
    ..of the SWI-SNF subunits in the different tumor lines revealed that A427 are deficient for BRG-1 and its homologue, Brm, whereas RB-sensitive cell lines retained Brm expression...
  27. Mizutani T, Ishizaka A, Tomizawa M, Okazaki T, Yamamichi N, Kawana Tachikawa A, et al. Loss of the Brm-type SWI/SNF chromatin remodeling complex is a strong barrier to the Tat-independent transcriptional elongation of human immunodeficiency virus type 1 transcripts. J Virol. 2009;83:11569-80 pubmed publisher
    ..We transduced this construct into human tumor cell lines that were either deficient in or competent for the Brm-type SWI/SNF complex...
  28. Basset A, Herd M, Daly R, Dove S, Malley R. The Pneumococcal Type 1 Pilus Genes Are Thermoregulated and Are Repressed by a Member of the Snf2 Protein Family. J Bacteriol. 2017;199: pubmed publisher
    ..Finally, we exploited the effect of low temperature on pilus gene expression to help identify SP_1523, an Snf2-type protein, as a novel negative regulator of the pilus genes...
  29. Priedigkeit N, Hartmaier R, Chen Y, Varešlija D, Basudan A, Watters R, et al. Intrinsic Subtype Switching and Acquired ERBB2/HER2 Amplifications and Mutations in Breast Cancer Brain Metastases. JAMA Oncol. 2017;3:666-671 pubmed publisher
    Patients with breast cancer (BrCa) brain metastases (BrM) have limited therapeutic options. A better understanding of molecular alterations acquired in BrM could identify clinically actionable metastatic dependencies...
  30. Zhu P, Wang Y, Wu J, Huang G, Liu B, Ye B, et al. LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells. Nat Commun. 2016;7:13608 pubmed publisher
    ..In liver CSCs, lncBRM associates with BRM to initiate the BRG1/BRM switch and the BRG1-embedded BAF complex triggers activation of YAP1 signalling...
  31. Phelan M, Schnitzler G, Kingston R. Octamer transfer and creation of stably remodeled nucleosomes by human SWI-SNF and its isolated ATPases. Mol Cell Biol. 2000;20:6380-9 pubmed
    ..The isolated hSWI-SNF ATPase subunits BRG1 and hBRM also have these activities...
  32. Sen P, Luo J, Hada A, Hailu S, Dechassa M, Persinger J, et al. Loss of Snf5 Induces Formation of an Aberrant SWI/SNF Complex. Cell Rep. 2017;18:2135-2147 pubmed publisher
    ..shown by crosslinking-mass spectrometry (CX-MS) and subunit deletion analysis to interact with the ATPase domain of Snf2 and to form a submodule consisting of Snf5, Swp82, and Taf14...
  33. Mohanty B, Silva A, Mackay J, Ryan D. 1H, 13C and 15N resonance assignments of a C-terminal domain of human CHD1. Biomol NMR Assign. 2016;10:31-4 pubmed publisher
    ..CHD1 possesses a pair of tandem chromodomains that directly precede the core catalytic Snf2 helicase-like domain, and a C-terminal SANT-SLIDE DNA-binding domain...
  34. Thompson K, Marquez S, Lu L, Reisman D. Induction of functional Brm protein from Brm knockout mice. Oncoscience. 2015;2:349-61 pubmed
    Once the knockout of the Brm gene was found to be nontumorigenic in mice, the study of BRM's involvement in cancer seemed less important compared with that of its homolog, Brg1...
  35. Tseng Y, Cabot B, Cabot R. ARID1A, a component of SWI/SNF chromatin remodeling complexes, is required for porcine embryo development. Mol Reprod Dev. 2017;: pubmed publisher
    ..These large, multi-protein complexes possess an SNF2-type ATPase (either SMARCA4 or SMARCA2) as their core catalytic subunit, and are directed to specific loci by ..
  36. Hu K, Nan X, Bird A, Wang W. Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex. Nat Genet. 2006;38:962-4; author reply 964-7 pubmed
  37. Shinojima A, Fujita K, Mori R, Kawamura A, Yuzawa M, Yasukawa T. Investigation of the Etiology of Central Serous Chorioretinopathy Using En-Face Optical Coherence Tomography and Indocyanine Green Angiography. Ophthalmologica. 2016;236:100-7 pubmed publisher
    ..En-face swept-source OCT images were automatically segmented and flattened with Bruch's membrane (BrM)...
  38. Aguilar Del Rey F, Garcia Portales R, Haro Liger M, Rodríguez Andreu J, Casals Sánchez J, Pérez González R. [Effect of tumour necrosis factor ? blockade on bone metabolism in chronic inflammatory joint diseases]. Med Clin (Barc). 2016;147:56-62 pubmed publisher
    To evaluate the effect of anti-TNF treatments on bone mineral density (BMD), bone remodelling markers (BRM) and receptor activator of nuclear factor ?B ligand (RANKL) and osteoprotegerin (OPG) in patients with chronic inflammatory joint ..
  39. Guerrero Martínez J, Reyes J. High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer. Sci Rep. 2018;8:2043 pubmed publisher
    ..prognosis, and clinicopathological data to clarify the role of SMARCA4 and the alternative SWI/SNF ATPase SMARCA2 (BRM) in cancer...
  40. Levinger I, Yan X, Bishop D, Houweling P, Papadimitriou I, Munson F, et al. The influence of ?-actinin-3 deficiency on bone remodelling markers in young men. Bone. 2017;98:26-30 pubmed publisher
    ..actinin-3 (ACTN3), a sarcomeric protein, is expressed in skeletal muscle and osteoblasts and may influence BRM levels and the cross-talk between muscle and bone...
  41. Korpanty G, Eng L, Qiu X, Faluyi O, Renouf D, Cheng D, et al. Association of BRM promoter polymorphisms and esophageal adenocarcinoma outcome. Oncotarget. 2017;8:28093-28100 pubmed publisher
    Brahma (BRM) is a critical catalytic subunit of the SWI/SNF chromatin remodeling complex; expression of BRM is commonly lost in various cancer types...
  42. Yamamichi N, Inada K, Furukawa C, Sakurai K, Tando T, Ishizaka A, et al. Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells. Exp Cell Res. 2009;315:1779-89 pubmed publisher
    In our recent study showing a correlation between Brm-deficiency and undifferentiated status of gastric cancer, we found that the Brm-type SWI/SNF complex is required for villin expression...
  43. Marquez Vilendrer S, Rai S, Gramling S, Lu L, Reisman D. BRG1 and BRM loss selectively impacts RB and P53, respectively: BRG1 and BRM have differential functions in vivo. Oncoscience. 2016;3:337-350 pubmed publisher
    ..The catalytic subunits of SWI/SNF, BRG1 and BRM, are frequently lost alone or concomitantly in a range of different cancer types...
  44. Li X, Jiang Y, Ji Z, Liu Y, Zhang Q. BRHIS1 suppresses rice innate immunity through binding to monoubiquitinated H2A and H2B variants. EMBO Rep. 2015;16:1192-202 pubmed publisher
    ..Here, we show that a rice SWI/SNF2 ATPase gene BRHIS1 is downregulated in response to the rice blast fungal pathogen or to the defense-priming-..
  45. Kothandapani A, Gopalakrishnan K, Kahali B, Reisman D, Patrick S. Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity. Exp Cell Res. 2012;318:1973-86 pubmed publisher
    ..In this report, we investigated the role of SWI/SNF catalytic subunits Brg1 and Brm in the cellular response to cisplatin in lung cancer and head/neck cancer cells...
  46. Alpsoy A, Dykhuizen E. Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. J Biol Chem. 2018;293:3892-3903 pubmed publisher
    ..It contains a central ATPase (BRM or BRG1) and various combinations of 10-14 accessory subunits (BAFs for BRM/BRG1 Associated F..
  47. Hassib S, Elkady E, Sayed R. Simultaneous determination of timolol maleate in combination with some other anti-glaucoma drugs in rabbit aqueous humor by high performance liquid chromatography-tandem mass spectroscopy. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1022:109-117 pubmed publisher
    ..drugs of different classes, namely; dorzolamide hydrochloride (DOR), brinzolamide (BRZ) and brimonidine tartrate (BRM) in rabbit aqueous humor (AH) using eslicarbazepine as an internal standard (IS)...
  48. Kozmik Z, Machon O, Kralova J, Kreslova J, Paces J, Vlcek C. Characterization of mammalian orthologues of the Drosophila osa gene: cDNA cloning, expression, chromosomal localization, and direct physical interaction with Brahma chromatin-remodeling complex. Genomics. 2001;73:140-8 pubmed
    ..We present evidence that the OSA1 product is localized in the nucleus and associates with human Brahma complex, which suggests evolutionarily conserved function for Osa in gene regulation between mammals and Drosophila. ..
  49. Redekar N, Biyashev R, Jensen R, Helm R, Grabau E, Maroof M. Genome-wide transcriptome analyses of developing seeds from low and normal phytic acid soybean lines. BMC Genomics. 2015;16:1074 pubmed publisher
    ..metabolism, cellular transport, photosynthesis and 9 transcription factor families including WRKY, CAMTA3 and SNF2 were enriched during seed development...
  50. Sun A, Tawfik O, Gayed B, Thrasher J, Hoestje S, Li C, et al. Aberrant expression of SWI/SNF catalytic subunits BRG1/BRM is associated with tumor development and increased invasiveness in prostate cancers. Prostate. 2007;67:203-13 pubmed
    Brahma gene (BRM) and Brahma-related gene 1 (BRG1) are major components with ATPase enzymatic activities in the nucleosome remodeling SWI/SNF complex, and their expression pattern in human prostate cancers is unknown...
  51. Dutta A, Sardiu M, Gogol M, Gilmore J, Zhang D, Florens L, et al. Composition and Function of Mutant Swi/Snf Complexes. Cell Rep. 2017;18:2124-2134 pubmed publisher
    ..In addition, we find that subunits of the Swi/Snf complex regulate occupancy of the catalytic subunit Snf2, thereby modulating gene transcription...
  52. Chan Penebre E, Armstrong K, Drew A, Grassian A, Feldman I, Knutson S, et al. Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models. Mol Cancer Ther. 2017;16:850-860 pubmed publisher
    ..These results exemplify an additional class of rhabdoid-like tumors that are dependent on EZH2 activity for survival. Mol Cancer Ther; 16(5); 850-60. ©2017 AACR. ..
  53. Zhu B, Ueda A, Song X, Horike S, Yokota T, Akagi T. Baf53a is involved in survival of mouse ES cells, which can be compensated by Baf53b. Sci Rep. 2017;7:14059 pubmed publisher
    The human Baf (Brg1/Brm associated factor) complex, also known as the mammalian SWI/SNF chromatin-remodeling complex, is involved in a variety of cellular processes...
  54. Chung S, Low S, Zembutsu H, Takahashi A, Kubo M, Sasa M, et al. A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Breast Cancer Res. 2013;15:R81 pubmed
  55. Damiano L, Stewart K, Cohet N, Mouw J, Lakins J, Debnath J, et al. Oncogenic targeting of BRM drives malignancy through C/EBP?-dependent induction of ?5 integrin. Oncogene. 2014;33:2441-53 pubmed publisher
    ..determined that MEK activates c-Myc to reduce the transcription of the SWI/SNF chromatin remodeling enzyme Brahma (BRM)...
  56. Kahali B, Gramling S, Marquez S, Thompson K, Lu L, Reisman D. Identifying targets for the restoration and reactivation of BRM. Oncogene. 2014;33:653-64 pubmed publisher
    Brahma (BRM) is a novel anticancer gene, which is frequently inactivated in a variety of tumor types. Unlike many anticancer genes, BRM is not mutated, but rather epigenetically silenced...
  57. Inayoshi Y, Miyake K, Machida Y, Kaneoka H, Terajima M, Dohda T, et al. Mammalian chromatin remodeling complex SWI/SNF is essential for enhanced expression of the albumin gene during liver development. J Biochem. 2006;139:177-88 pubmed
    ..SWI/SNF contains the Swi2p/Snf2p like ATPases BRG1 or BRM exclusively...
  58. Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E. Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest. Mol Cell Biol. 1999;19:1460-9 pubmed
    ..BRG1 and BAF155, mammalian homologs of yeast SWI2 and SWI3, respectively, are found in cyclin E complexes and are phosphorylated by cyclin E-associated kinase ..
  59. Banday S, Farooq Z, Rashid R, Abdullah E, Altaf M. Role of Inner Nuclear Membrane Protein Complex Lem2-Nur1 in Heterochromatic Gene Silencing. J Biol Chem. 2016;291:20021-9 pubmed publisher
    ..Finally, we show that the Lem2-Nur1 complex regulates the local balance between the underln]Snf2/HDAC-containing repressor complex (SHREC) histone deacetylase complex and the anti-silencing protein Epe1...
  60. Fontana G, Rigamonti A, Lenzken S, Filosa G, Alvarez R, Calogero R, et al. Oxidative stress controls the choice of alternative last exons via a Brahma-BRCA1-CstF pathway. Nucleic Acids Res. 2017;45:902-914 pubmed publisher
    ..Here, we show that Brahma (BRM), the ATPase subunit of the hSWI/SNF chromatin-remodeling complex interacts with BRCA1/BARD1, which ubiquitinates ..
  61. Muller C, Calkhoven C, Sha X, Leutz A. The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest. J Biol Chem. 2004;279:7353-8 pubmed
  62. Bourachot B, Yaniv M, Muchardt C. Growth inhibition by the mammalian SWI-SNF subunit Brm is regulated by acetylation. EMBO J. 2003;22:6505-15 pubmed
    ..chromatin-remodeling complex is a regulator of cell proliferation, and overexpression of the catalytic subunit Brm interferes with cell cycle progression...
  63. Liu Z, Myers L. Candida albicans Swi/Snf and Mediator Complexes Differentially Regulate Mrr1-Induced MDR1 Expression and Fluconazole Resistance. Antimicrob Agents Chemother. 2017;61: pubmed publisher
    ..Deletion of snf2, the catalytic subunit of Swi/Snf, largely abrogates the increases in MDR1 expression and fluconazole ..
  64. Mehrotra A, Saladi S, Trivedi A, Aras S, Qi H, Jayanthy A, et al. Modulation of Brahma expression by the mitogen-activated protein kinase/extracellular signal regulated kinase pathway is associated with changes in melanoma proliferation. Arch Biochem Biophys. 2014;563:125-35 pubmed publisher
    Brahma (BRM) and Brahma-related gene 1(BRG1) are catalytic subunits of SWItch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes. BRM is epigenetically silenced in a wide-range of tumors...
  65. Endo M, Yasui K, Zen Y, Gen Y, Zen K, Tsuji K, et al. Alterations of the SWI/SNF chromatin remodelling subunit-BRG1 and BRM in hepatocellular carcinoma. Liver Int. 2013;33:105-17 pubmed publisher
    The SWI/SNF chromatin remodelling complex, which contains either brahma-related gene-1 (BRG1) or brahma (BRM) as the catalytic ATPase, functions as a master regulator of gene expression...
  66. Liu G, Cuffe S, Liang S, Azad A, Cheng L, Brhane Y, et al. BRM Promoter Polymorphisms and Survival of Advanced Non-Small Cell Lung Cancer Patients in the Princess Margaret Cohort and CCTG BR.24 Trial. Clin Cancer Res. 2017;23:2460-2470 pubmed publisher
    b>Introduction: BRM, a key catalytic subunit of the SWI/SNF chromatin remodeling complex, is a putative tumor susceptibility gene that is silenced in 15% of non-small cell lung cancer (NSCLC)...
  67. Zhang Y, Cheng M, Zhang Y, Zhong X, Dai H, Yan L, et al. A switch from hBrm to Brg1 at IFN?-activated sequences mediates the activation of human genes. Cell Res. 2010;20:1345-60 pubmed publisher
    ..Here, we studied the roles of human Brahma (hBrm) and Brahma-related gene 1 (Brg1), the ATPase subunits of the SWI/SNF complexes, in regulating human genes...
  68. Lee J, Lake R, Kirk J, Bohr V, Fan H, Hohng S. NAP1L1 accelerates activation and decreases pausing to enhance nucleosome remodeling by CSB. Nucleic Acids Res. 2017;45:4696-4707 pubmed publisher
    Cockayne syndrome protein B (CSB) belongs to the SWI2/SNF2 ATP-dependent chromatin remodeler family, and CSB is the only ATP-dependent chromatin remodeler essential for transcription-coupled nucleotide excision DNA repair...
  69. Van Houdt J, Nowakowska B, Sousa S, van Schaik B, Seuntjens E, Avonce N, et al. Heterozygous missense mutations in SMARCA2 cause Nicolaides-Baraitser syndrome. Nat Genet. 2012;44:445-9, S1 pubmed publisher
    ..These alterations likely do not impair SWI/SNF complex assembly but may be associated with disrupted ATPase activity. The identification of SMARCA2 mutations in humans provides insight into the function of the Snf2 helicase family.
  70. Keenen B, Qi H, Saladi S, Yeung M, de la Serna I. Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma. Oncogene. 2010;29:81-92 pubmed publisher
    ..SWI/SNF chromatin remodeling enzymes are multiprotein complexes composed of one of two related ATPases, BRG1 or BRM, and 9-12-associated factors (BAFs)...
  71. Kowenz Leutz E, Pless O, Dittmar G, Knoblich M, Leutz A. Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code. EMBO J. 2010;29:1105-15 pubmed publisher
    ..Thus, phosphorylation of the transcription factor C/EBPbeta couples ras signalling to arginine methylation and regulates the interaction of C/EBPbeta with epigenetic gene regulatory protein complexes during cell differentiation. ..
  72. Liu K, Luo Y, Lin F, Lin W. TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival. Genes Dev. 2004;18:673-86 pubmed
    ..This regulation of E2F1 transcriptional activity is mediated by a pRb-independent, but Brg1/Brm-dependent mechanism...
  73. Roy K, de la Serna I, Imbalzano A. The myogenic basic helix-loop-helix family of transcription factors shows similar requirements for SWI/SNF chromatin remodeling enzymes during muscle differentiation in culture. J Biol Chem. 2002;277:33818-24 pubmed
    ..and myogenin-mediated induction of muscle differentiation in cells expressing dominant negative versions of BRG1 or BRM-based SWI/SNF enzymes...
  74. Fang F, Chen D, Yu L, Dai X, Yang Y, Tian W, et al. Proinflammatory stimuli engage Brahma related gene 1 and Brahma in endothelial injury. Circ Res. 2013;113:986-96 pubmed publisher
    ..Our goal was to determine the involvement of Brahma related gene 1 (Brg1) and Brahma (Brm) in CAM transactivation and its relevance in the pathogenesis of atherosclerosis...