BRD2

Summary

Gene Symbol: BRD2
Description: bromodomain containing 2
Alias: BRD2-IT1, D6S113E, FSH, FSRG1, NAT, O27.1.1, RING3, RNF3, bromodomain-containing protein 2, BRD2 intronic transcript 1, female sterile homeotic-related gene 1, really interesting new gene 3 protein
Species: human
Products:     BRD2

Top Publications

  1. Zhou M, Xu X, Zhou H, Liu H, He J, Li X, et al. BRD2 is one of BRD7-interacting proteins and its over-expression could initiate apoptosis. Mol Cell Biochem. 2006;292:205-12 pubmed
    BRD7 is a potential nuclear transcription regulation factor related to nasopharyngeal carcinoma (NPC). BRD2, a putative BRD7-interacting protein, has been screened from human fetal brain cDNA library by yeast two-hybrid system...
  2. Taniguchi Y, Matsuzaka Y, Fujimoto H, Miyado K, Kohda A, Okumura K, et al. Nucleotide sequence of the ring3 gene in the class II region of the mouse MHC and its abundant expression in testicular germ cells. Genomics. 1998;51:114-23 pubmed
    The RING3 (NAT) gene is the first and only locus with no obvious function associated with the immune system in the class II region of the human major histocompatibility complex...
  3. Kanno T, Kanno Y, Siegel R, Jang M, Lenardo M, Ozato K. Selective recognition of acetylated histones by bromodomain proteins visualized in living cells. Mol Cell. 2004;13:33-43 pubmed
    ..The bromodomain protein Brd2 selectively interacted with acetylated lysine 12 on histone H4, whereas TAF(II)250 and PCAF recognized H3 and other ..
  4. You J, Srinivasan V, Denis G, Harrington W, Ballestas M, Kaye K, et al. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes. J Virol. 2006;80:8909-19 pubmed
    ..Although another bromodomain protein, RING3/Brd2, binds to LANA in a similar fashion in vitro, it is largely excluded from the mitotic chromosomes in KSHV-..
  5. Umehara T, Nakamura Y, Wakamori M, Ozato K, Yokoyama S, Padmanabhan B. Structural implications for K5/K12-di-acetylated histone H4 recognition by the second bromodomain of BRD2. FEBS Lett. 2010;584:3901-8 pubmed publisher
    ..The structural mechanism for how the N-terminal bromodomain of human BRD2 (BRD2-BD1) deciphers the mono-acetylated status of histone H4 tail was recently reported...
  6. Haynes S, Dollard C, Winston F, Beck S, Trowsdale J, Dawid I. The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins. Nucleic Acids Res. 1992;20:2603 pubmed
  7. Crowley T, Kaine E, Yoshida M, Nandi A, Wolgemuth D. Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein. Mol Endocrinol. 2002;16:1727-37 pubmed
    b>Fsrg1 (female sterile homeotic-related gene 1) is the mouse homolog of the human RING3 protein, which has been shown to associate with the E2 promoter binding factor (E2F) transcription factor and to have a possible role in cell cycle-..
  8. Denis G, Vaziri C, Guo N, Faller D. RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F. Cell Growth Differ. 2000;11:417-24 pubmed
    b>RING3 is a novel, nuclear-localized, serine-threonine kinase that has elevated activity in human leukemias...
  9. Denis G, Green M. A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator. Genes Dev. 1996;10:261-71 pubmed
    ..gene that encodes this nuclear kinase and find that it is closely related to Drosophila female sterile homeotic (fsh), a developmental regulator with no known biochemical activity...

More Information

Publications120 found, 100 shown here

  1. Greenwald R, Tumang J, Sinha A, Currier N, Cardiff R, Rothstein T, et al. E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia. Blood. 2004;103:1475-84 pubmed
    Transgenic mice with lymphoid-restricted overexpression of the double bromodomain protein bromodomain-containing 2 (Brd2) develop splenic B-cell lymphoma and, upon transplantation, B-cell leukemia with leukemic infiltrates in liver and ..
  2. Sinha A, Faller D, Denis G. Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A. Biochem J. 2005;387:257-69 pubmed
    ..We have identified a double bromo-domain-containing protein Brd2, which exhibits apparent 'scaffold' or transcriptional adapter functions and mediates recruitment of both E2F ..
  3. Peng J, Dong W, Chen L, Zou T, Qi Y, Liu Y. Brd2 is a TBP-associated protein and recruits TBP into E2F-1 transcriptional complex in response to serum stimulation. Mol Cell Biochem. 2007;294:45-54 pubmed
    b>Brd2 is a novel protein kinase and plays a role in cell cycle-responsive transcription. Recent studies show that Brd2 contributes to E2F-1 regulated cell cycle progression...
  4. Huang H, Zhang J, Shen W, Wang X, Wu J, Wu J, et al. Solution structure of the second bromodomain of Brd2 and its specific interaction with acetylated histone tails. BMC Struct Biol. 2007;7:57 pubmed
    b>Brd2 is a transcriptional regulator and belongs to BET family, a less characterized novel class of bromodomain-containing proteins...
  5. LeRoy G, Rickards B, Flint S. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. Mol Cell. 2008;30:51-60 pubmed publisher
    ..Here, we report that the double bromodomain proteins Brd2 and Brd3 associate preferentially in vivo with hyperacetylated chromatin along the entire lengths of transcribed ..
  6. Beck S, Hanson I, Kelly A, Pappin D, Trowsdale J. A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC. DNA Seq. 1992;2:203-10 pubmed
    The RING3 gene maps in the class II region of the human major histocompatibility complex, at a CpG island distal of the HLA-DNA gene. RING3 cDNAs were obtained from a T cell cDNA library and the longest (4 kb) was sequenced...
  7. Pal D, Evgrafov O, Tabares P, Zhang F, Durner M, Greenberg D. BRD2 (RING3) is a probable major susceptibility gene for common juvenile myoclonic epilepsy. Am J Hum Genet. 2003;73:261-70 pubmed
    ..SNP) and microsatellite markers in this critical region, with LD peaking in the BRD2 (RING3) gene (odds ratio 6.45; 95% confidence interval 2.36-17.58)...
  8. Denis G, McComb M, Faller D, Sinha A, Romesser P, Costello C. Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines. J Proteome Res. 2006;5:502-11 pubmed
    We use affinity purification of the double bromodomain protein Brd2 to isolate a multicomponent nuclear complex from cultured cells, and apply mass spectrometry/proteomics methods to identify the participants...
  9. Nakamura Y, Umehara T, Nakano K, Jang M, Shirouzu M, Morita S, et al. Crystal structure of the human BRD2 bromodomain: insights into dimerization and recognition of acetylated histone H4. J Biol Chem. 2007;282:4193-201 pubmed
    ..One of the BET proteins, BRD2, associates with the transcription factor E2F, the mediator components CDK8 and TRAP220, and RNA polymerase II, as ..
  10. Xiong Y, Chen H, Lin P, Wang A, Wang L, Jin Y. ATF6 knockdown decreases apoptosis, arrests the S phase of the cell cycle, and increases steroid hormone production in mouse granulosa cells. Am J Physiol Cell Physiol. 2017;312:C341-C353 pubmed publisher
    ..b>FSH or LH treatment significantly increased ATF6 protein levels in mouse granulosa cells...
  11. Wijayarathna R, de Kretser D. Activins in reproductive biology and beyond. Hum Reprod Update. 2016;22:342-57 pubmed publisher
    ..growth factor-beta (TGF-?) superfamily of cytokines, initially isolated for their capacity to induce the release of FSH from pituitary extracts...
  12. Hart R, Doherty D, McLachlan R, Walls M, Keelan J, Dickinson J, et al. Testicular function in a birth cohort of young men. Hum Reprod. 2015;30:2713-24 pubmed publisher
    ..Australia, Crawley, Perth and were analysed for serum luteinizing hormone (LH), follicular stimulating hormone (FSH), inhibin B, testosterone, dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), estradiol, estrone and the ..
  13. Wang Y, Li Y, Zhang B, Zhang F. The preclinical evaluation of immunocontraceptive vaccines based on canine zona pellucida 3 (cZP3) in a mouse model. Reprod Biol Endocrinol. 2018;16:47 pubmed publisher
    ..The levels of follicle stimulating hormone (FSH) and estradiol (E2) in sera were significantly decreased in OGZ immunized mice...
  14. Chen Y, Wu Y, Gan X, Liu K, Lv X, Shen H, et al. Iridoid glycoside from Cornus officinalis ameliorated diabetes mellitus-induced testicular damage in male rats: Involvement of suppression of the AGEs/RAGE/p38 MAPK signaling pathway. J Ethnopharmacol. 2016;194:850-860 pubmed publisher
    ..weight ratio and live sperm rate, improving the histomorphology of testes, upregulating testosterone, LH, FSH and GnRH levels and preventing the decrease of testicular marker enzymes LDH, ACP and ?-GT...
  15. Hsiao C, Ji A, Chang C, Cheng C, Lee L, Ho J. Local injection of mesenchymal stem cells protects testicular torsion-induced germ cell injury. Stem Cell Res Ther. 2015;6:113 pubmed publisher
    ..MDA) assay in testis and plasma, hormones level including testosterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by ELISA Kits, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) ..
  16. Li Q, Wu W, Lin H, Chang X, Bian H, Xia M, et al. Serum retinol binding protein 4 is negatively related to estrogen in Chinese women with obesity: a cross-sectional study. Lipids Health Dis. 2016;15:52 pubmed publisher
    ..and laboratory tests, including lipid profile, luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), estradiol (E2),progesterone (PROG), testosterone (TESTO), and dehydroepiandrosterone (DHEA) were ..
  17. Wang J, Qian X, Gao Q, Lv C, Xu J, Jin H, et al. Quercetin increases the antioxidant capacity of the ovary in menopausal rats and in ovarian granulosa cell culture in vitro. J Ovarian Res. 2018;11:51 pubmed publisher
    ..The levels of the hormones estradiol (E2), progesterone (P), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were detected by radioimmunoassay...
  18. Mishra B, Ortiz L, Luderer U. Charged iron particles, components of space radiation, destroy ovarian follicles. Hum Reprod. 2016;31:1816-26 pubmed publisher
    ..We quantified the numbers of ovarian follicles, measured serum follicle stimulating hormone (FSH) and luteinizing hormone (LH) concentrations, and analyzed histone H2AX phosphorylation, oxidative damage and ..
  19. Mohamed N, Ahmed O, Hozayen W, Ahmed M. Ameliorative effects of bee pollen and date palm pollen on the glycemic state and male sexual dysfunctions in streptozotocin-Induced diabetic wistar rats. Biomed Pharmacother. 2018;97:9-18 pubmed publisher
    ..weights, levels of serum insulin, testosterone, luteinizing hormone (LH) & follicle stimulating hormone (FSH) as well as sperm count, motility and viability...
  20. Lu J, Jing J, Chen L, Ge Y, Feng R, Liang Y, et al. Analysis of human sperm DNA fragmentation index (DFI) related factors: a report of 1010 subfertile men in China. Reprod Biol Endocrinol. 2018;16:23 pubmed publisher
    ..001). Sperm DFI was positively related to serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels and seminal plasma FSH and estradiol (E2) levels (P<0...
  21. Sharma P, Aslam Khan I, Singh R. Curcumin and Quercetin Ameliorated Cypermethrin and Deltamethrin-Induced Reproductive System Impairment in Male Wistar Rats by Upregulating The Activity of Pituitary-Gonadal Hormones and Steroidogenic Enzymes. Int J Fertil Steril. 2018;12:72-80 pubmed publisher
    ..testosterone (T), follicle stimulating hormone (FSH) and luteinizing hormone (LH), steroidogenic enzymes viz...
  22. Lotti F, Corona G, Vitale P, Maseroli E, Rossi M, Fino M, et al. Current smoking is associated with lower seminal vesicles and ejaculate volume, despite higher testosterone levels, in male subjects of infertile couples. Hum Reprod. 2015;30:590-602 pubmed publisher
    ..001; calculated free testosterone, P < 0.005) and lower FSH (P < 0.05) levels were observed in CS...
  23. Zhou X, Chou T, Aubol B, Park C, Wolfenden R, Adams J, et al. Kinetic mechanism of human histidine triad nucleotide binding protein 1. Biochemistry. 2013;52:3588-600 pubmed publisher
    ..et al. (2012) Nat. Genet. 44, 1080-1083]...
  24. Qin N, Fan X, Xu X, Tyasi T, Li S, Zhang Y, et al. Cooperative Effects of FOXL2 with the Members of TGF-β Superfamily on FSH Receptor mRNA Expression and Granulosa Cell Proliferation from Hen Prehierarchical Follicles. PLoS ONE. 2015;10:e0141062 pubmed publisher
    ..This cooperative action may be mediated by the examined Smad signals and simultaneously implicated in modulation of the StAR, CCND2, and CYP11A1 expression. ..
  25. Shavit T, Agdi M, Son W, Hasson J, Dahan M. A comparison between r-LH and urinary supplements containing LH activity in patients undergoing the microdose GnRH agonist flare protocol for in-vitro fertilization: a pilot study. Minerva Ginecol. 2016;68:393-9 pubmed
    ..Comparisons between the group that was stimulated with r-LH plus follicle stimulating hormone (FSH) to those treated with hMG and FSH, were performed...
  26. Li H, Zhu H, Qin Q, Lei M, Shi Z. Production of biologically active recombinant goose FSH in a single chain form with a CTP linker sequence. Mol Biol Rep. 2017;44:11-17 pubmed publisher
    b>FSH is a glycoprotein hormone secreted by the pituitary gland that is essential for gonadal development and reproductive function...
  27. Chan J, Atianand M, Jiang Z, Carpenter S, Aiello D, Elling R, et al. Cutting Edge: A Natural Antisense Transcript, AS-IL1α, Controls Inducible Transcription of the Proinflammatory Cytokine IL-1α. J Immunol. 2015;195:1359-63 pubmed publisher
    ..In this study, we identified and characterized a novel NAT, AS-IL1α, which is partially complementary to IL-1α...
  28. Atli G, Ariyurek S, Kanak E, Canli M. Alterations in the serum biomarkers belonging to different metabolic systems of fish (Oreochromis niloticus) after Cd and Pb exposures. Environ Toxicol Pharmacol. 2015;40:508-15 pubmed publisher
    ..of the endocrine system functioning in different axis, namely HPI (cortisol), HPT (TSH, T3, T4), gonadal (LH, FSH) and prolactin...
  29. Liang Y, Yuan W, Zhang S, He Z, Xue J, Zhang X, et al. Hydrothermal synthesis and structural characterization of metal-organic frameworks based on new tetradentate ligands. Dalton Trans. 2016;45:1382-90 pubmed publisher
    ..is a three-dimensional (3D) framework with a 2-fold interpenetrated form, which exhibits a 2-nodal (3,4)-connected fsh-3,4-P21/c net with a {8(3)}2{8(5)·10} topology...
  30. Amorim S, Stathis A, Gleeson M, Iyengar S, Magarotto V, Leleu X, et al. Bromodomain inhibitor OTX015 in patients with lymphoma or multiple myeloma: a dose-escalation, open-label, pharmacokinetic, phase 1 study. Lancet Haematol. 2016;3:e196-204 pubmed publisher
    The first-in-class small molecule inhibitor OTX015 (MK-8628) specifically binds to bromodomain motifs BRD2, BRD3, and BRD4 of bromodomain and extraterminal (BET) proteins, inhibiting them from binding to acetylated histones, which occurs ..
  31. Khanh V, Ohneda K, Kato T, Yamashita T, Sato F, Tachi K, et al. Uremic Toxins Affect the Imbalance of Redox State and Overexpression of Prolyl Hydroxylase 2 in Human Adipose Tissue-Derived Mesenchymal Stem Cells Involved in Wound Healing. Stem Cells Dev. 2017;26:948-963 pubmed publisher
    ..tissue-derived MSCs (CKD-AT-MSCs) have the same function in wound healing as healthy donor-derived normal AT-MSCs (nAT-MSCs)...
  32. Pinto P, Velez Z, Sousa C, Santos S, Andrade A, Alvarado M, et al. Responsiveness of pituitary to galanin throughout the reproductive cycle of male European sea bass (Dicentrarchus labrax). Gen Comp Endocrinol. 2017;250:152-161 pubmed publisher
    ..Furthermore 1-29Gal was able to stimulate both follicle stimulating hormone (Fsh) and luteinizing hormone (Lh) release from pituitary cell suspensions...
  33. Janouskova H, El Tekle G, Bellini E, Udeshi N, Rinaldi A, Ulbricht A, et al. Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors. Nat Med. 2017;23:1046-1054 pubmed publisher
    ..analyzed changes in the ubiquitin landscape induced by endometrial cancer-associated SPOP mutations and identified BRD2, BRD3 and BRD4 proteins (BETs) as SPOP-CUL3 substrates that are preferentially degraded by endometrial cancer-..
  34. Matsumoto K, Imakawa K, Hayashi C. Successful pregnancy and live birth from a hypogonadotropic hypogonadism woman with low serum estradiol concentrations despite numerous oocyte maturations: a case report. BMC Pregnancy Childbirth. 2017;17:312 pubmed publisher
    ..stimulation is performed to hypogonadotropic hypogonadism (HH) patients with only follicle stimulating hormone (FSH), proper increase in serum E2 concentrations is not observed...
  35. Nome R, Bjøro T, Paus E, Bjerner J, Fosså S, Steen R, et al. Lowered reference limits for hCG improve follow-up of patients with hCG-producing tumors. Clin Biochem. 2018;52:73-79 pubmed publisher
    ..The gonadotropins LH and FSH were measured in the cohort and in a selection of the reference population to assess gonadal function...
  36. Wu Y, Barad D, Kushnir V, Wang Q, Zhang L, Darmon S, et al. With low ovarian reserve, Highly Individualized Egg Retrieval (HIER) improves IVF results by avoiding premature luteinization. J Ovarian Res. 2018;11:23 pubmed publisher
    ..RNA was extracted and real-time PCR analyses performed, with gene expressions at mRNA level investigated for FSH receptor (FSHR), luteinizing hormone receptor (LHCPR), P450 aromatase (CYP19a1) and progesterone receptor (PGR)...
  37. Wierzbicka Tutka I, Sokołowski G, Bałdys Waligórska A, Adamek D, Radwańska E, Gołkowski F. PTTG and Ki-67 expression in pituitary adenomas. Przegl Lek. 2016;73:53-8 pubmed
    ..Tumours with positive immunostaining towards FSH revealed lower Ki-67 and PTTG indices than the rest with a negative one (0.6% vs.1.84%, p = 0.0004 and 0.67% vs 1...
  38. Abbasihormozi S, Kouhkan A, Alizadeh A, Shahverdi A, Nasr Esfahani M, Sadighi Gilani M, et al. Association of vitamin D status with semen quality and reproductive hormones in Iranian subfertile men. Andrology. 2017;5:113-118 pubmed publisher
    ..men, serum vitamin D levels categorized were not correlated with semen parameters and reproductive hormones (FSH, LH, testosterone(T), and FT), whereas sperm motility showed a positive correlation with vitamin D categorized in ..
  39. Ran S, Yu Q, Deng S, Xu L. Luteinizing hormone elevation in ovarian granulosa cell tumor: a case report and review of the literature. J Ovarian Res. 2017;10:30 pubmed publisher
    ..A 33-year-old woman presented with secondary amenorrhea and elevated LH with normal FSH and low estradiol levels...
  40. Gollavilli P, Pawar A, Wilder Romans K, Natesan R, Engelke C, Dommeti V, et al. EWS/ETS-Driven Ewing Sarcoma Requires BET Bromodomain Proteins. Cancer Res. 2018;78:4760-4773 pubmed publisher
    ..EWS/FLI1 and EWS/ERG were found in a transcriptional complex with BRD4, and knockdown of BRD2/3/4 significantly impaired the oncogenic phenotype of EWS cells...
  41. Paccola C, Miraglia S. Prenatal and lactation nicotine exposure affects Sertoli cell and gonadotropin levels in rats. Reproduction. 2016;151:117-33 pubmed publisher
    ..Male offsprings (30, 60, and 90 days old) had blood collected for hormonal analysis (FSH and LH) and their testes submitted for histophatological study, analysis of the frequency of the stages of ..
  42. Gleicher N, Darmon S, Kushnir V, Weghofer A, Wang Q, Zhang L, et al. How FSH and AMH reflect probabilities of oocyte numbers in poor prognosis patients with small oocyte yields. Endocrine. 2016;54:476-483 pubmed
  43. Dewailly D, Robin G, Peigné M, Decanter C, Pigny P, Catteau Jonard S. Interactions between androgens, FSH, anti-Müllerian hormone and estradiol during folliculogenesis in the human normal and polycystic ovary. Hum Reprod Update. 2016;22:709-724 pubmed
    Androgens, FSH, anti-Müllerian hormone (AMH) and estradiol (E2) are essential in human ovarian folliculogenesis. However, the interactions between these four players is not fully understood...
  44. Ho C, Tan H. Treatment of the Hypogonadal Infertile Male-A Review. Sex Med Rev. 2013;1:42-49 pubmed publisher
    ..hormone, human chorionic gonadotropin (hCG), human menopausal gonadotropin (hMG), follicle-stimulating hormone (FSH), and anti-estrogens and aromatase inhibitors. Dopamine antagonist is indicated for prolactinoma...
  45. Gong J, Lai Y, Li X, Wang M, Leitz J, Hu Y, et al. C-terminal domain of mammalian complexin-1 localizes to highly curved membranes. Proc Natl Acad Sci U S A. 2016;113:E7590-E7599 pubmed
    ..b>Nat Commun 5:4955]. The curvature-sensing value of the C-terminal domain is comparable to that of α-synuclein...
  46. Olah Z, Kremmer T, Vogg A, Varga Z, Szucs Z, Neumaier B, et al. Novel ion exchange chromatography method for nca arsenic separation. Appl Radiat Isot. 2017;122:111-115 pubmed publisher
    ..device equipped with an anion exchange column was used to isolate nca 77As from reactor irradiated natGeO2 targets...
  47. Stocco C, Baumgarten S, Armouti M, Fierro M, Winston N, Scoccia B, et al. Genome-wide interactions between FSH and insulin-like growth factors in the regulation of human granulosa cell differentiation. Hum Reprod. 2017;32:905-914 pubmed publisher
    Is the genome-wide response of human cumulus cells to FSH and insulin-like growth factors (IGFs) comparable to the response observed in undifferentiated granulosa cells (GCs)? FSH actions in human cumulus cells mimic those observed in ..
  48. Milone M, Sosa Fernandez L, Sosa Fernandez L, Manigrasso M, Elmore U, De Palma G, et al. Does Bariatric Surgery Improve Assisted Reproductive Technology Outcomes in Obese Infertile Women?. Obes Surg. 2017;27:2106-2112 pubmed publisher
    ..ART outcomes were compared evaluating the duration and dose of gonadotrophins used; the measurement of day 3 FSH; the anti-mullerian hormone dosage; the number of follicles >15 mm; the number of retrieved and fertilized ..
  49. Li X, Sun Z, Manthari R, Li M, Guo Q, Wang J. Effect of gestational exposure to arsenic on puberty in offspring female mice. Chemosphere. 2018;202:119-126 pubmed publisher
    ..uterus organ coefficient, reproductive hormone levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH), mRNA and protein expression levels of kiss-1, hypothalamus gonadotrophin releasing hormone 1 (GnRH1), organic ..
  50. Himeda C, Jones T, Jones P. CRISPR/dCas9-mediated Transcriptional Inhibition Ameliorates the Epigenetic Dysregulation at D4Z4 and Represses DUX4-fl in FSH Muscular Dystrophy. Mol Ther. 2016;24:527-35 pubmed publisher
    ..These results implicate the promoter and exon 1 of DUX4 as potential therapeutic targets and demonstrate the utility of CRISPR technology for correction of the epigenetic dysregulation in FSHD. ..
  51. Abdelrazik A, Ezzat Ahmed G. Priority needs and wisdom strategy for blood transfusion safety in developing low-resource countries. Transfus Apher Sci. 2016;54:147-9 pubmed publisher
    ..Although NAT reduces the window period of infection, the developing countries are still in need of an efficient and effective ..
  52. Regan S, Knight P, Yovich J, Stanger J, Leung Y, Arfuso F, et al. Infertility and ovarian follicle reserve depletion are associated with dysregulation of the FSH and LH receptor density in human antral follicles. Mol Cell Endocrinol. 2017;446:40-51 pubmed publisher
    ..Oocyte depletion causes an irreversible change to ovarian function. We found that the young patient FSH receptor and LH receptor expression profile on the granulosa cells collected from different size follicles were ..
  53. Kang J, Grivnin A, Bor E, Reiner J, Avraham N, Ronen Y, et al. Robust Epitaxial Al Coating of Reclined InAs Nanowires. Nano Lett. 2017;: pubmed publisher
    ..indium arsenide nanowires is possible and yields superior properties relative to ex-situ evaporation of aluminum ( Nat. Mater. 2015 , 14 , 400 - 406 )...
  54. Sandoval Castro C. Do condensed tannins from Lysiloma latisiliquum have a role in its anthelmintic activity?. Nat Prod Res. 2017;:1-3 pubmed publisher
    We would like to comment on a recent paper by Hernandez-Bolio et al. (2017, Nat. Prod. Res. DOI: 10.1080/14786419.2017...
  55. Hussain Z, Uyama T, Kawai K, Binte Mustafiz S, Tsuboi K, Araki N, et al. Phosphatidylserine-stimulated production of N-acyl-phosphatidylethanolamines by Ca2+-dependent N-acyltransferase. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:493-502 pubmed publisher
    ..A2 (cPLA2?) was recently identified as a Ca2+-dependent N-acyltransferase (Ca-NAT). In the present study, we first showed that two isoforms of human cPLA2? function as Ca-NAT...
  56. Vollmer T, Knabbe C, Dreier J. Systematic Evaluation of Different Nucleic Acid Amplification Assays for Cytomegalovirus Detection: Feasibility of Blood Donor Screening. J Clin Microbiol. 2015;53:3219-25 pubmed publisher
    ..8 ml, Chemagic Viral 5K kit; PerkinElmer) for blood donor pool screening (MP-nucleic acid testing [NAT]) and with the Nuclisens easyMAG system (0.5 ml; bioMérieux) for individual donation (ID)-NAT...
  57. Nabati A, Peivandi S, Khalilian A, Mirzaeirad S, Hashemi S. Comparison of GnRh Agonist Microdose Flare Up and GnRh Antagonist/Letrozole in Treatment of Poor Responder Patients in Intra Cytoplaspic Sperm Injection: Randomized Clinical Trial. Glob J Health Sci. 2015;8:166-71 pubmed publisher
    ..this randomized clinical trial study consisted of 123 patients. In the first step of treatment in both methods FSH, LH, estradiol, anderostandion, testestron in third day of menstruation period and the thickness of endometrium by ..
  58. Żebracka Gala J, Rudnik A, Hasse Lazar K, Larysz D, Jarząb M, Krajewska J, et al. Molecular classification of pituitary adenomas: in search for criteria useful for high-throughput studies. Endokrynol Pol. 2016;67:148-56 pubmed publisher
    ..LHb and FSHb genes showed the highest expression, respectively, in LH-producing and FSH-producing pituitary adenomas; however, our analysis did not show statistically significant differences between LH-..
  59. Li Y, Pan P, Yuan P, Qiu Q, Yang D. Successful live birth in a woman with resistant ovary syndrome following in vitro maturation of oocytes. J Ovarian Res. 2016;9:54 pubmed publisher
    ..There were no abnormal findings in some autoantibody assays and FSH receptor sequencing...
  60. Easterbrook P. Who to test and how to test for chronic hepatitis C infection - 2016 WHO testing guidance for low- and middle-income countries. J Hepatol. 2016;65:S46-S66 pubmed publisher
    ..directions and innovations in viral hepatitis testing include use of point-of-care assays for nucleic acid testing (NAT) and core antigen; validation of dried blood spots specimens with different commercial serological and NAT assays; ..
  61. Ciardo F, Schimberni M, Giallonardo A, De Pratti V, Sbracia M. Short gonadotropin-releasing hormone agonist versus flexible antagonist versus clomiphene citrate regimens in poor responders undergoing in vitro fertilization: a randomized controlled trial. Eur Rev Med Pharmacol Sci. 2016;20:4354-4361 pubmed
    ..We divided into three groups: group A, 68 women treated with clomiphene citrate and FSH plus antagonist; Group B, 71 patients treated with FSH plus antagonist; Group C, 75 patients treated with FSH plus ..
  62. Matsuno Y, Onuma A, Fujioka Y, Yasuhara K, Fujii W, Naito K, et al. Effects of exosome-like vesicles on cumulus expansion in pigs in vitro. J Reprod Dev. 2017;63:51-58 pubmed publisher
    ..not capable of inducing cumulus expansion to a degree comparable to that induced by follicle-stimulating hormone (FSH)...
  63. Cheung K, Zhang F, Jaganathan A, Sharma R, Zhang Q, Konuma T, et al. Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation. Mol Cell. 2017;65:1068-1080.e5 pubmed publisher
    ..In this study, we report that the BET family members Brd2 and Brd4 exert distinct genomic functions at genes whose transcription they co-regulate during mouse T helper 17 (..
  64. Kitamura S, Abiko K, Matsumura N, Nakai H, Akimoto Y, Tanimoto H, et al. Adult granulosa cell tumors of the ovary: a retrospective study of 30 cases with respect to the expression of steroid synthesis enzymes. J Gynecol Oncol. 2017;28:e31 pubmed publisher
    ..081). Serum follicle-stimulating hormone (FSH) levels were low in all patients irrespective of serum Eâ‚‚ levels...
  65. Liu H, Tao Y, Luo P, Deng C, Gu Y, Yang L, et al. Preventive Effects of a Novel Polysaccharide from Sepia esculenta Ink on Ovarian Failure and Its Action Mechanisms in Cyclophosphamide-Treated Mice. J Agric Food Chem. 2016;64:5759-66 pubmed publisher
    ..of mice which caused depletion of various follicles, and led to a reduction in estradiol content, increases in FSH and LH contents in sera, decreases in ovary and uterus masses and their relative mass ratios, disruption of the ..
  66. Reddy T, Govatati S, Deenadayal M, Sisinthy S, Bhanoori M. Impact of mitochondrial DNA copy number and displacement loop alterations on polycystic ovary syndrome risk in south Indian women. Mitochondrion. 2017;: pubmed publisher
    ..001 and 0.006 respectively). The D310 carriers also showed significantly elevated LH/FSH ratio (P=0.026)...
  67. Tripathy M, Priyam M, Rai U. Repertoire of bone morphogenetic proteins and growth/differentiation factors in ovary of the Indian wall lizard (Hemidactylus flaviviridis) with emphasis on differential expression and gonadotropic regulation of bmp15 and gdf9. Gen Comp Endocrinol. 2017;253:13-24 pubmed publisher
    ..increased while gdf9 decreased in parallel to follicular development after administration of 3 injections of FSH. Expression of both the growth factors declined with the prolongation of treatment that led to formation of early/..
  68. Okamoto N, Ando A, Kawai J, Yoshiwara T, Tsuji K, Inoko H. Orientation of HLA-DNA gene and identification of a CpG island-associated gene adjacent to DNA in human major histocompatibility complex class II region. Hum Immunol. 1991;32:221-8 pubmed
    ..that it represented a new non-HLA gene with a single copy which was of little genetic polymorphism and named NAT (DNA-associated transcript)...
  69. Wei Y, Hu Z, Gu W, Liu G, Shi B, Liu E, et al. CD117+CD44+ Stem T Cells Develop in the Thymus and Potently Suppress T-cell Proliferation by Modulating the CTLA-4 Pathway. Stem Cell Res Ther. 2017;8:56 pubmed publisher
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    ..that is involved in folliculogenesis and oocyte maturation, which is regulated by follicle-stimulating hormone (FSH), as a key reproductive hormone during follicular development...
  72. Khan H, Bhatti S, Abbas S, Khan Y, Aslamkhan M, Gonzalez R, et al. Tri-nucleotide consortium of androgen receptor is associated with low serum FSH and testosterone in asthenospermic men. Syst Biol Reprod Med. 2018;64:112-121 pubmed publisher
    ..Our findings suggest that long (>26 CAG)n repeats have an inverse correlation with circulatory FSH and T, whereas long (>25 GGC)n repeats have moderated affiliation with reduced sperm concentration...
  73. Tretyakov D, Beterov I, Yakshina E, Entin V, Ryabtsev I, Cheinet P, et al. Observation of the Borromean Three-Body Förster Resonances for Three Interacting Rb Rydberg Atoms. Phys Rev Lett. 2017;119:173402 pubmed publisher
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    ..However, in normoglycemic women, glucose levels were associated with DNA methylation changes at LRP1B and BRD2 and at CACNA1D and LRP1B gene loci in placenta and cord blood, respectively...
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    ..in anestrous Rideau Arcott ewes superstimulated for ovarian follicular development with multiple doses of porcine FSH (pFSH) was evaluated in a single study. Twenty-five animals received six (1×2.5ml and 5×1...
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    Neoadjuvant treatment (NAT) of breast cancer (BCa) is an option for patients with the locally advanced disease. It has been compared with standard adjuvant therapy with the aim of improving prognosis and surgical outcome...
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    ..Serum level of testosterone, follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, oxidative stress markers in the testicular tissue, epididymal sperm health ..
  78. Daney de Marcillac F, Pinton A, Guillaume A, Sagot P, Pirrello O, Rongieres C. What are the likely IVF/ICSI outcomes if there is a discrepancy between serum AMH and FSH levels? A multicenter retrospective study. J Gynecol Obstet Hum Reprod. 2017;46:629-635 pubmed publisher
    ..micro-injection (ICSI) in patients whom ovarian reserve testing revealed a discrepancy between the serum levels of FSH and AMH. The secondary outcome was to determine whether AMH and FSH profiles could predict the IVF/ICSI response...
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    b>FSH receptor (FSHR) Ala307Thr and Asn680Ser and LH? chain (LHB) Trp28Arg and Ile35Thr polymorphisms affect the response to pharmacological ovarian stimulation with r-FSH in women undergoing assisted reproductive treatment (ART)...
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    ..Ovarian superstimulation with FSH and eCG alone or in combination is somewhat successful...
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    ..Results showed that treatment of human cumulus granulosa cells with 20 ?M ATR for 48 h resulted in lower FSH-stimulated estradiol and progesterone production...
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    ..produced a transient inflammatory response that was followed by a decline in serum testosterone, without changes in LH or FSH, providing further evidence that endotoxin-driven inflammation may results in impaired Leydig cell function.
  85. Lee A, Rayner S, De Luca A, Gwee S, Morsch M, Sundaramoorthy V, et al. Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex. Open Biol. 2017;7: pubmed publisher
    ..of patients with familial and sporadic ALS and frontotemporal dementia (FTD) (Williams KL et al 2016 Nat. Commun.7, 11253. (doi:10.1038/ncomms11253))...
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    To evaluate expression of progesterone receptor (PGR) AB in follicle stimulating hormone (FSH)-treated or non-treated sheep administered with arginine (Arg) or saline (Sal) fed a control (C), excess (O) or restricted (U) diet, uterine ..
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    ..Bhattacharya et al. (J. Chem. Theory Comput. 2017, 13, 1682-1690) without fitting parameters. The results show good accord with current measurements (Nat. Phys. 2017, 13, 35-38).
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    ..b>Nat Rev Mol Cell Biol 16(1):57-64, 2014; Ricke and van Deursen, Semin Cell Dev Biol 22(6):559-565, 2011; Holland and ..
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    ..crystal structures of CDS from Thermococcus onnurineus NA1 (ToCDS), which include native internal aldimine (NAT), gem-diamine (GD) with alanine, internal aldimine structure with existing alanine (IAA), and internal aldimine ..
  90. Wang P, Shehu A, Lu J, Joshi R, Venkataramanan R, Sugamori K, et al. Deficiency of N-acetyltransferase increases the interactions of isoniazid with endobiotics in mouse liver. Biochem Pharmacol. 2017;145:218-225 pubmed publisher
    ..The current study used Nat1/2(-/-) mice to mimic NAT slow metabolizers and to investigate INH metabolism in the liver...
  91. Chevereau M, Glatt H, Zalko D, Cravedi J, Audebert M. Role of human sulfotransferase 1A1 and N-acetyltransferase 2 in the metabolic activation of 16 heterocyclic amines and related heterocyclics to genotoxicants in recombinant V79 cells. Arch Toxicol. 2017;91:3175-3184 pubmed publisher
    ..Some studies have indicated a role of human sulfotransferase (SULT) 1A1 and N-acetyltransferase (NAT) 2 in the terminal activation of HAAs...