BPIFA2

Summary

Gene Symbol: BPIFA2
Description: BPI fold containing family A member 2
Alias: C20orf70, PSP, SPLUNC2, bA49G10.1, BPI fold-containing family A member 2, parotid secretory protein, short palate, lung and nasal epithelium carcinoma-associated protein 2
Species: human
Products:     BPIFA2

Top Publications

  1. González Arriagada W, Ramos L, Silva A, Vargas P, Coletta R, Bingle L, et al. Salivary BPIFA1 (SPLUNC1) and BPIFA2 (SPLUNC2 A) are modified by head and neck cancer radiotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119:48-58 pubmed publisher
    ..BPIFA1 and BPIFA2 expression was detected by western blotting and analyzed along with clinicopathologic data and side effects from ..
  2. Metzler M, Venkatesh S, Lakshmanan J, Carenbauer A, Perez S, Andres S, et al. A systems biology approach identifies a regulatory network in parotid acinar cell terminal differentiation. PLoS ONE. 2015;10:e0125153 pubmed publisher
    ..In addition, Xbp1 and Mist1 each activate the parotid secretory protein (Psp) gene, which encodes an abundant salivary protein, and is a marker of terminal differentiation...
  3. Wang A, Duncan S, Lesser G, Ray W, Dietrich A. Effect of lactoferrin on taste and smell abnormalities induced by chemotherapy: a proteome analysis. Food Funct. 2018;9:4948-4958 pubmed publisher
    ..Abundance of ?-amylase and SPLUNC2 were further increased (P < 0.05) at 30-day post-LF supplementation in cancer patients...
  4. Musa M, Wilson K, Sun L, Mulay A, Bingle L, Marriott H, et al. Differential localisation of BPIFA1 (SPLUNC1) and BPIFB1 (LPLUNC1) in the nasal and oral cavities of mice. Cell Tissue Res. 2012;350:455-64 pubmed publisher
    ..in the proximal tongue where is co-localised with the salivary gland specific family member, BPIFA2E (parotid secretory protein) and also in glands of the soft palate...
  5. Suresh L, Malyavantham K, Shen L, Ambrus J. Investigation of novel autoantibodies in Sjogren's syndrome utilizing Sera from the Sjogren's international collaborative clinical alliance cohort. BMC Ophthalmol. 2015;15:38 pubmed publisher
    ..novel autoantibodies, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) and parotid secretory protein (PSP). These novel antibodies are seen in the animals at an earlier stage of SS than anti-Ro and anti-La...
  6. Everett S, Vishwanath S, Cavero V, Shen L, Suresh L, Malyavantham K, et al. Analysis of novel Sjogren's syndrome autoantibodies in patients with dry eyes. BMC Ophthalmol. 2017;17:20 pubmed publisher
    ..identified autoantibodies, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) and anti-parotid secretory protein (PSP), which occur early in the course of SS...
  7. Beckman K, Luchs J, Milner M, Ambrus J. The Potential Role for Early Biomarker Testing as Part of a Modern, Multidisciplinary Approach to Sjögren's Syndrome Diagnosis. Adv Ther. 2017;34:799-812 pubmed publisher
    ..to proteins specific to the salivary and lacrimal glands [SP-1 (salivary gland protein-1), PSP (parotid secretory protein), CA-6 (carbonic anhydrase VI)]...
  8. Karakus S, Baer A, Agrawal D, Gürakar M, Massof R, Akpek E. Utility of Novel Autoantibodies in the Diagnosis of Sjögren's Syndrome Among Patients With Dry Eye. Cornea. 2018;37:405-411 pubmed publisher
    ..the value of 3 novel autoantibodies [salivary protein 1 (SP1), carbonic anhydrase 6 (CA6), and parotid secretory protein (PSP)] in differentiating Sjögren's syndrome (SS)-related dry eye from non-SS dry eye...
  9. Robinson C, Bounous D, Alford C, Nguyen K, Nanni J, Peck A, et al. PSP expression in murine lacrimal glands and function as a bacteria binding protein in exocrine secretions. Am J Physiol. 1997;272:G863-71 pubmed
    ..mice, an animal model for type I autoimmune diabetes and autoimmune sialoadenitis, abnormally express parotid secretory protein (PSP) in the submandibular glands (Robinson, C. P., H. Yamamoto, A. B. Peck, and M. G. Humphreys-Beher...

More Information

Publications16

  1. Bingle C, Craven C. PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. Hum Mol Genet. 2002;11:937-43 pubmed
    ..We suggest that members of the PLUNC family may function in the innate immune response in regions of the mouth, nose and lungs, which are sites of significant bacterial exposure. ..
  2. Vargas P, Speight P, Bingle C, Barrett A, Bingle L. Expression of PLUNC family members in benign and malignant salivary gland tumours. Oral Dis. 2008;14:613-9 pubmed publisher
    ..data were collected retrospectively and immunohistochemical analysis of three PLUNC proteins (SPLUNC1, SPLUNC2 and LPLUNC1) was performed. Immunoreactivity was assessed as positive or negative...
  3. Prokopovic V, Popovic M, Andjelković U, Marsavelski A, Raskovic B, Gavrovic Jankulovic M, et al. Isolation, biochemical characterization and anti-bacterial activity of BPIFA2 protein. Arch Oral Biol. 2014;59:302-9 pubmed publisher
    Human BPIFA2 (parotid secretory protein) is a ubiquitous soluble salivary protein, which belongs to the PLUNC family of proteins...
  4. Kota S, Pernicone E, Leaf D, Stillman I, Waikar S, KOTA S. BPI Fold-Containing Family A Member 2/Parotid Secretory Protein Is an Early Biomarker of AKI. J Am Soc Nephrol. 2017;28:3473-3478 pubmed publisher
    ..We assessed the utility as such of BPI fold-containing family A member 2 (BPIFA2), also known as parotid secretory protein, which we identified via a multiplex quantitative proteomics screen of acutely injured murine ..
  5. Bingle L, Barnes F, Lunn H, Musa M, Webster S, Douglas C, et al. Characterisation and expression of SPLUNC2, the human orthologue of rodent parotid secretory protein. Histochem Cell Biol. 2009;132:339-49 pubmed publisher
    ..We now describe the generation and characterisation of novel affinity-purified antibodies to SPLUNC2, and use them to determine the expression of this, the major salivary gland PLUNC...
  6. Abdolhosseini M, Sotsky J, Shelar A, Joyce P, Gorr S. Human parotid secretory protein is a lipopolysaccharide-binding protein: identification of an anti-inflammatory peptide domain. Mol Cell Biochem. 2012;359:1-8 pubmed publisher
    b>Parotid secretory protein (PSP) (C20orf70) is a salivary protein of unknown function...
  7. Gorr S, Abdolhosseini M, Shelar A, Sotsky J. Dual host-defence functions of SPLUNC2/PSP and synthetic peptides derived from the protein. Biochem Soc Trans. 2011;39:1028-32 pubmed publisher
    PSP (parotid secretory protein)/SPLUNC2 (short palate, lung and nasal epithelium clone 2) is expressed in human salivary glands and saliva...