Gene Symbol: BORCS8-MEF2B
Description: BORCS8-MEF2B readthrough
Alias: LOC729991-MEF2B, MEF2B, MEF2BNB-MEF2B, myocyte enhancer factor 2B, LOC729991-MEF2B readthrough, MEF2BNB-MEF2B readthrough
Species: human
Products:     BORCS8-MEF2B

Top Publications

  1. Lei X, Shi H, Kou Y, Rajashekar N, Wu F, Sen C, et al. Crystal Structure of Apo MEF2B Reveals New Insights in DNA Binding and Cofactor Interaction. Biochemistry. 2018;57:4047-4051 pubmed publisher
    ..Here we determined the structure of the MADS-box/MEF2 domain of MEF2B without DNA nor cofactor...
  2. Sun W, Hu S, Hu J, Qiu J, Yang S, Hu B, et al. Akirin1 promotes myoblast differentiation by modulating multiple myoblast differentiation factors. Biosci Rep. 2019;39: pubmed publisher
    ..differentiation by increasing the expression of myogenic regulatory factor (MRF) 4 (MRF4) and myocyte enhancer factor 2B (MEF2B) mRNA...
  3. Moore E, Swerdlow S, Gibson S. Comparison of Myocyte Enhancer Factor 2B Versus Other Germinal Center-associated Antigens in the Differential Diagnosis of B-Cell Non-Hodgkin Lymphomas. Am J Surg Pathol. 2018;42:342-350 pubmed publisher
    Myocyte enhancer binding factor 2B (MEF2B) is a transcriptional activator of the BCL6 proto-oncogene in normal germinal center (GC) B-cells...
  4. Martis P, Dudley A, Bemrose M, Gazda H, Smith B, Gazda L. MEF2 plays a significant role in the tumor inhibitory mechanism of encapsulated RENCA cells via EGF receptor signaling in target tumor cells. BMC Cancer. 2018;18:1217 pubmed publisher
    ..significantly up-regulated the activity of the MEF2 transcription factor as well as altered the transcription of MEF2b and MEF2d isoforms in targeted tumor cells...
  5. El Jamal S, Grada Z, El Dinali M, Zhou H, Hassan S, Saad A, et al. MEF2B is a member of the BCL6 gene transcriptional complex and induces its expression in diffuse large B-cell lymphoma of the germinal center B-cell-like type. Lab Invest. 2019;99:539-550 pubmed publisher
    Myocyte enhancer-binding factor 2B (MEF2B) has been implicated as a transcriptional regulator for BCL6...
  6. Brescia P, Schneider C, Holmes A, Shen Q, Hussein S, Pasqualucci L, et al. MEF2B Instructs Germinal Center Development and Acts as an Oncogene in B Cell Lymphomagenesis. Cancer Cell. 2018;34:453-465.e9 pubmed publisher
    The gene encoding the MEF2B transcription factor is mutated in germinal center (GC)-derived B cell lymphomas, but its role in GC development and lymphomagenesis is unknown...
  7. Chen L, Cheng B, Li L, Zhan S, Wang L, Zhong T, et al. The molecular characterization and temporal-spatial expression of myocyte enhancer factor 2 genes in the goat and their association with myofiber traits. Gene. 2015;555:223-30 pubmed publisher
    The myocyte enhancer factor-2 (MEF2) gene family in vertebrates includes MEF2A, MEF2B, MEF2C, and MEF2D, which have important functions in the regulation of muscular growth and development...
  8. Estrella N, Desjardins C, Nocco S, Clark A, Maksimenko Y, Naya F. MEF2 transcription factors regulate distinct gene programs in mammalian skeletal muscle differentiation. J Biol Chem. 2015;290:1256-68 pubmed publisher
    ..Whereas MEF2A is absolutely required for proper myoblast differentiation, MEF2B, -C, and -D were found to be dispensable for this process...
  9. Wu Y, Dey R, Han A, Jayathilaka N, Philips M, Ye J, et al. Structure of the MADS-box/MEF2 domain of MEF2A bound to DNA and its implication for myocardin recruitment. J Mol Biol. 2010;397:520-33 pubmed publisher
    ..The current structure also suggests that the ligand-binding pocket previously observed in the Cabin1-MEF2B-DNA complex and the HDAC9 (histone deacetylase 9)-MEF2B-DNA complex is not induced by cofactor binding but rather ..

More Information


  1. Ding J, Dirks W, Ehrentraut S, Geffers R, MacLeod R, Nagel S, et al. BCL6--regulated by AhR/ARNT and wild-type MEF2B--drives expression of germinal center markers MYBL1 and LMO2. Haematologica. 2015;100:801-9 pubmed publisher
    ..AhR) and the resulting activity of the AhR/ARNT complex underlaid differential regulation of 11 genes including MEF2B. Knock-down and inhibitor experiments confirmed that AhR/ARNT regulates MEF2B, a key transcription factor for BCL6...
  2. Pierzynski J, Ye Y, Lippman S, Rodriguez M, Wu X, Hildebrandt M. Socio-demographic, Clinical, and Genetic Determinants of Quality of Life in Lung Cancer Patients. Sci Rep. 2018;8:10640 pubmed publisher
    ..001, MCS Ptrend?<?0.001). Similar relationships were seen for MCS. The homozygous rare genotype of MEF2B: rs2040562 showed an increased risk of a poor MCS (OR: 3.06, 95% CI: 1.05-8.92, P?=?0.041)...
  3. Rodríguez A, Csányi G, Ranayhossaini D, Feck D, Blose K, Assatourian L, et al. MEF2B-Nox1 signaling is critical for stretch-induced phenotypic modulation of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2015;35:430-8 pubmed publisher
    ..was designed to test the hypothesis that pathological CS stimulates NADPH oxidase isoform 1 (Nox1)-derived ROS via MEF2B, leading to VSMC dysfunction via a switch from a contractile to a synthetic phenotype...
  4. Hirai H, Yang B, Garcia Barrio M, Rom O, Ma P, Zhang J, et al. Direct Reprogramming of Fibroblasts Into Smooth Muscle-Like Cells With Defined Transcription Factors-Brief Report. Arterioscler Thromb Vasc Biol. 2018;38:2191-2197 pubmed publisher
    ..of transcription factors, including Myocd (myocardin), Mef2C (myocyte enhancer factor 2C), Mef2B (myocyte enhancer factor 2B), Mkl1 (MKL [megakaryoblastic leukemia]/Myocd-like 1), Gata4 (GATA-binding protein 4), Gata5 (GATA-..
  5. Bödör C, Grossmann V, Popov N, Okosun J, O Riain C, Tan K, et al. EZH2 mutations are frequent and represent an early event in follicular lymphoma. Blood. 2013;122:3165-8 pubmed publisher
    ..By comparing VAF of EZH2 with other mutation targets (CREBBP, MLL2, TNFRSF14, and MEF2B), we were able to distinguish patients harboring clonal EZH2 mutation from rarer cases with subclonal mutations...
  6. Pavan S, Meyer Schaller N, Diepenbruck M, Kalathur R, Saxena M, Christofori G. A kinome-wide high-content siRNA screen identifies MEK5-ERK5 signaling as critical for breast cancer cell EMT and metastasis. Oncogene. 2018;37:4197-4213 pubmed publisher
    ..The results suggest that the MEK5-ERK5 signaling axis via activation of MEF2B and other transcription factors plays an important role in the induction and maintenance of breast cancer cell ..
  7. Pon J, Wong J, Saberi S, Alder O, Moksa M, Grace Cheng S, et al. MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation. Nat Commun. 2015;6:7953 pubmed publisher
    b>Myocyte enhancer factor 2B (MEF2B) is a transcription factor with mutation hotspots at K4, Y69 and D83 in diffuse large B-cell lymphoma (DLBCL)...
  8. Tempera I, De Leo A, Kossenkov A, Cesaroni M, Song H, Dawany N, et al. Identification of MEF2B, EBF1, and IL6R as Direct Gene Targets of Epstein-Barr Virus (EBV) Nuclear Antigen 1 Critical for EBV-Infected B-Lymphocyte Survival. J Virol. 2016;90:345-55 pubmed publisher
    ..EBNA1 bound to genes of high significance for B-cell growth and function, including MEF2B, IL6R, and EBF1...
  9. Nielsen J, Sedgwick C, Shahid A, Zong Z, Brumme Z, Yu S, et al. Toward Personalized Lymphoma Immunotherapy: Identification of Common Driver Mutations Recognized by Patient CD8+ T Cells. Clin Cancer Res. 2016;22:2226-36 pubmed publisher
    ..T-cell responses were directed toward putative driver mutations in CREBBP and MEF2B. Responding T cells showed exquisite specificity for mutant versus wild-type proteins and recognized lymphoma ..
  10. Lei X, Kou Y, Fu Y, Rajashekar N, Shi H, Wu F, et al. The Cancer Mutation D83V Induces an α-Helix to β-Strand Conformation Switch in MEF2B. J Mol Biol. 2018;430:1157-1172 pubmed publisher
    b>MEF2B is a major target of somatic mutations in non-Hodgkin lymphoma. Most of these mutations are non-synonymous substitutions of surface residues in the MADS-box/MEF2 domain...
  11. Zhang L, Ma X, Xuan J, Wang H, Yuan Z, Wu M, et al. Identification of MEF2B and TRHDE Gene Polymorphisms Related to Growth Traits in a New Ujumqin Sheep Population. PLoS ONE. 2016;11:e0159504 pubmed publisher
    2 SNPs were discovered in our previous genome-wide association study (GWAS): s58995.1 (rs420767326 A>G) in MEF2B gene and OAR3_115712045...
  12. Won K, Im J, Kim B, Ban H, Jung Y, Jung K, et al. Stability of the cancer target DDIAS is regulated by the CHIP/HSP70 pathway in lung cancer cells. Cell Death Dis. 2017;8:e2554 pubmed publisher
    ..DDIAS is transcriptionally activated by NFATc1 and EGF-mediated ERK5/MEF2B, leading to cisplatin resistance and cell invasion...
  13. Im J, Yoon S, Kim B, Ban H, Won K, Chung K, et al. DNA damage induced apoptosis suppressor (DDIAS) is upregulated via ERK5/MEF2B signaling and promotes ?-catenin-mediated invasion. Biochim Biophys Acta. 2016;1859:1449-1458 pubmed publisher
    ..we demonstrate that DDIAS expression is induced by extracellular signal-regulated kinase 5 (ERK5) and myocyte enhancer factor 2B (MEF2B) in response to epidermal growth factor (EGF) and that it positively regulates ?-catenin ..
  14. Wen C, Jiang X, Ding L, Wang T, Zhou Y. Effects of dietary methionine on breast muscle growth, myogenic gene expression and IGF-I signaling in fast- and slow-growing broilers. Sci Rep. 2017;7:1924 pubmed publisher
    ..diets increased mRNA levels of myogenic regulatory factors (MRF4, Myf5) and myocyte enhancer factor 2 (MEF2A and MEF2B) in the FG broilers, and increased MEF2A and decreased myostatin mRNA level in the SG broilers...
  15. Krenács D, Borbényi Z, Bedekovics J, Méhes G, Bagdi E, Krenács L. Pattern of MEF2B expression in lymphoid tissues and in malignant lymphomas. Virchows Arch. 2015;467:345-55 pubmed publisher
    Myocyte enhancer binding factor 2 B (MEF2B) is a member of the evolutionary conserved transcription family MEF2...
  16. Ryan R, Drier Y, Whitton H, Cotton M, Kaur J, Issner R, et al. Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma. Cancer Discov. 2015;5:1058-71 pubmed publisher
    ..We show that BCL6-locus enhancers are acetylated by the BCL6-activating transcription factor MEF2B, and can undergo genomic duplication, or target the MYC promoter for activation in the context of a "pseudo-double-..
  17. Pastore A, Jurinovic V, Kridel R, Hoster E, Staiger A, Szczepanowski M, et al. Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: a retrospective analysis of a prospective clinical trial and validation in a population-based registry. Lancet Oncol. 2015;16:1111-1122 pubmed publisher
    ..a clinicogenetic risk model (termed m7-FLIPI) that included the mutation status of seven genes (EZH2, ARID1A, MEF2B, EP300, FOXO1, CREBBP, and CARD11), the Follicular Lymphoma International Prognostic Index (FLIPI), and Eastern ..
  18. Wu C, de Miranda N, Chen L, Wasik A, Mansouri L, Jurczak W, et al. Genetic heterogeneity in primary and relapsed mantle cell lymphomas: Impact of recurrent CARD11 mutations. Oncotarget. 2016;7:38180-38190 pubmed publisher
    ..Eighteen genes were found to be recurrently mutated in these samples, including known (ATM, MEF2B and MLL2) and novel mutation targets (S1PR1 and CARD11)...
  19. Pon J, Marra M. MEF2 transcription factors: developmental regulators and emerging cancer genes. Oncotarget. 2016;7:2297-312 pubmed publisher
    ..In particular, MEF2B, the most divergent and least studied protein of the MEF2 family, has a role unique from its paralogs in non-..
  20. Assouline S, Nielsen T, Yu S, Alcaide M, Chong L, MacDonald D, et al. Phase 2 study of panobinostat with or without rituximab in relapsed diffuse large B-cell lymphoma. Blood. 2016;128:185-94 pubmed publisher
    ..At time of data censoring, 6 of 11 patients had not progressed. Of the genes tested for mutations, only those in MEF2B were significantly associated with response...
  21. Pollock R, Treisman R. Human SRF-related proteins: DNA-binding properties and potential regulatory targets. Genes Dev. 1991;5:2327-41 pubmed
    ..We discuss the potential role of RSRF proteins in the regulation of these genes. ..
  22. Han A, Pan F, Stroud J, Youn H, Liu J, Chen L. Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2. Nature. 2003;422:730-4 pubmed
    ..Here we report a crystal structure of the MADS-box/MEF2S domain of human MEF2B bound to a motif of the transcriptional co-repressor Cabin1 and DNA at 2.2 A resolution...
  23. Li L, Rubin L, Gong X. MEF2 transcription factors in human placenta and involvement in cytotrophoblast invasion and differentiation. Physiol Genomics. 2018;50:10-19 pubmed publisher
    ..CTBs), we show that members of the MEF2 family are differentially expressed in human placental CTBs, with MEF2B and MEF2D being highly expressed in first trimester extravillous CTBs...
  24. Mottok A, Jurinovic V, Farinha P, Rosenwald A, Leich E, Ott G, et al. FOXP1 expression is a prognostic biomarker in follicular lymphoma treated with rituximab-containing regimens. Blood. 2017;: pubmed publisher
    ..We recently demonstrated that integration of mutation status of seven genes, including EZH2 and MEF2B, improves risk stratification...
  25. Moore E, Swerdlow S, Gibson S. J chain and myocyte enhancer factor 2B are useful in differentiating classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Hum Pathol. 2017;68:47-53 pubmed publisher
    ..We investigated the utility of J chain and myocyte enhancer factor 2B (MEF2B) in the diagnosis of CHL; NLPHL; PMBL; T-cell/histiocyte-rich large B-cell lymphoma (TCRLBL); and ..
  26. Yu Y, Breitbart R, Smoot L, Lee Y, Mahdavi V, Nadal Ginard B. Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors. Genes Dev. 1992;6:1783-98 pubmed
    ..Moreover, MEF2 is induced in nonmuscle cells by MyoD; however, MEF2 alone is insufficient to produce the full muscle phenotype. Implications for the molecular mechanisms of myogenesis are considered. ..
  27. Kahl B. Follicular lymphoma: are we ready for a risk-adapted approach?. Hematology Am Soc Hematol Educ Program. 2017;2017:358-364 pubmed publisher
    ..patients at high risk for poor outcomes to first-line therapy (mutational status of 7 genes [EZH2, ARID1A, MEF2B, EP300, FOX01, CREBBP, and CARD11] with Follicular Lymphoma International Prognostic Index)...
  28. Zhang Y, Ren J, Fang M, Wang X. Investigation of fusion gene expression in HCT116 cells. Oncol Lett. 2017;14:6962-6968 pubmed publisher
    ..i>EIF3E(e1)-RSPO2(e2), EIF3E(e1)-RSPO2(e3), PTPRK(e1)-RSPO3(e2), PTPRK(e7)-RSPO3(e2), TADA2A-MEF2B and MED13L-CD4 are fusion transcripts present in the transcriptome of the HCT116 colon cancer cell line...
  29. Youn H, Sun L, Prywes R, Liu J. Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2. Science. 1999;286:790-3 pubmed
    ..The interplay between Cabin1, MEF2, and calmodulin defines a distinct signaling pathway from the TCR to the Nur77 promoter during T cell apoptosis. ..
  30. Ito N, Kii I, Shimizu N, Tanaka H, Takeda S. Direct reprogramming of fibroblasts into skeletal muscle progenitor cells by transcription factors enriched in undifferentiated subpopulation of satellite cells. Sci Rep. 2017;7:8097 pubmed publisher
    ..Gene expression analysis of this subpopulation revealed that defined combinations of transcription factors (Pax3, Mef2b, and Pitx1 or Pax7, Mef2b, and Pitx1 in embryonic fibroblasts, and Pax7, Mef2b and MyoD in adult fibroblasts) ..