BNIP3

Summary

Gene Symbol: BNIP3
Description: BCL2 interacting protein 3
Alias: NIP3, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3, BCL2/adenovirus E1B 19kDa interacting protein 3
Species: human
Products:     BNIP3

Top Publications

  1. Moriyama M, Moriyama H, Uda J, Matsuyama A, Osawa M, Hayakawa T. BNIP3 plays crucial roles in the differentiation and maintenance of epidermal keratinocytes. J Invest Dermatol. 2014;134:1627-1635 pubmed publisher
    ..the epidermis of Hes1(-/-) mouse revealed the direct relationship between Hes1 (hairy and enhancer of split-1) and BNIP3 (BCL2 and adenovirus E1B 19-kDa-interacting protein 3), a potent inducer of autophagy...
  2. Landes T, Emorine L, Courilleau D, Rojo M, Belenguer P, Arnauné Pelloquin L. The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms. EMBO Rep. 2010;11:459-65 pubmed publisher
    ..We show that Bnip3 interacts with Opa1, leading to mitochondrial fragmentation and apoptosis...
  3. Yasuda M, Theodorakis P, Subramanian T, Chinnadurai G. Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and a mitochondrial targeting sequence. J Biol Chem. 1998;273:12415-21 pubmed
    ..Cellular protein BNIP3 (previously NIP3) interacts with E1B-19K, BCL-2, BCL-xL, and EBV-BHRF1...
  4. Leo C, Horn L, Hockel M. Hypoxia and expression of the proapoptotic regulator BNIP3 in cervical cancer. Int J Gynecol Cancer. 2006;16:1314-20 pubmed
    ..Here, we investigate the expression of Bcl-2/adenovirus E1B 19 kd-interacting protein 3 (BNIP3), a proapoptotic Bcl-2 family member, and its relationship to hypoxia in cervical cancer cell lines and clinical ..
  5. Erkan M, Kleeff J, Esposito I, Giese T, Ketterer K, Buchler M, et al. Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis. Oncogene. 2005;24:4421-32 pubmed
    ..In the present study, the hypoxia-inducible proapoptotic gene, BNIP3, was analysed in terms of expression, effect on patient survival, and chemo-responsiveness in pancreatic cancer ..
  6. Chen G, Cizeau J, Vande Velde C, Park J, Bozek G, Bolton J, et al. Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. J Biol Chem. 1999;274:7-10 pubmed
    We have identified Nix, a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Nip3. Human and murine Nix have a 56 and 53% amino acid identity to human and murine Nip3, respectively...
  7. Bellot G, Garcia Medina R, Gounon P, Chiche J, Roux D, Pouyssegur J, et al. Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol. 2009;29:2570-81 pubmed publisher
    ..Several studies implicate the HIF-induced putative BH3-only proapoptotic genes bnip3 and bnip3l in hypoxia-mediated cell death. We, like others, do not support this assertion...
  8. Azad M, Chen Y, Henson E, Cizeau J, McMillan Ward E, Israels S, et al. Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3. Autophagy. 2008;4:195-204 pubmed
    ..The pro-cell death Bcl-2 family member BNIP3 (Bcl-2/adenovirus E1B 19kDainteracting protein 3) is upregulated during hypoxia and is known to induce autophagy ..
  9. Manka D, Spicer Z, Millhorn D. Bcl-2/adenovirus E1B 19 kDa interacting protein-3 knockdown enables growth of breast cancer metastases in the lung, liver, and bone. Cancer Res. 2005;65:11689-93 pubmed

More Information

Publications88

  1. Okami J, Simeone D, Logsdon C. Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer. Cancer Res. 2004;64:5338-46 pubmed
    ..expression of a regulator of hypoxia-induced cell death, Bcl-2/adenovirus E1B 19 kDa interacting protein 3 (BNIP3)...
  2. Boyd J, Malstrom S, Subramanian T, Venkatesh L, Schaeper U, Elangovan B, et al. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. Cell. 1994;79:341-51 pubmed
    ..We have isolated cDNAs for three different proteins, designated Nip1, Nip2, and Nip3, that interact with the 19 kDa protein...
  3. Burton T, Eisenstat D, Gibson S. BNIP3 (Bcl-2 19 kDa interacting protein) acts as transcriptional repressor of apoptosis-inducing factor expression preventing cell death in human malignant gliomas. J Neurosci. 2009;29:4189-99 pubmed publisher
    The Bcl-2 19 kDa interacting protein (BNIP3) is a pro-cell-death BH3-only member of the Bcl-2 family...
  4. Tracy K, Dibling B, Spike B, Knabb J, Schumacker P, Macleod K. BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol. 2007;27:6229-42 pubmed
    ..Loss of pRb resulted in derepression of BNip3, a hypoxia-inducible member of the Bcl-2 superfamily of cell death regulators...
  5. Giatromanolaki A, Koukourakis M, Sowter H, Sivridis E, Gibson S, Gatter K, et al. BNIP3 expression is linked with hypoxia-regulated protein expression and with poor prognosis in non-small cell lung cancer. Clin Cancer Res. 2004;10:5566-71 pubmed
    b>BNIP3 is a proapoptotic protein regulated by hypoxia-inducible factor 1...
  6. Kubasiak L, Hernandez O, Bishopric N, Webster K. Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3. Proc Natl Acad Sci U S A. 2002;99:12825-30 pubmed
    ..We now report that hypoxia-acidosis-associated cell death is mediated by BNIP3, a member of the Bcl-2 family of apoptosis-regulating proteins...
  7. Shaw J, Yurkova N, Zhang T, Gang H, Aguilar F, Weidman D, et al. Antagonism of E2F-1 regulated Bnip3 transcription by NF-kappaB is essential for basal cell survival. Proc Natl Acad Sci U S A. 2008;105:20734-9 pubmed publisher
    ..The hypoxia-inducible death factor Bnip3 is an E2F-1 target gene and integral component of the intrinsic mitochondrial death pathway...
  8. Shaida N, Launchbury R, Boddy J, Jones C, Campo L, Turley H, et al. Expression of BNIP3 correlates with hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha and the androgen receptor in prostate cancer and is regulated directly by hypoxia but not androgens in cell lines. Prostate. 2008;68:336-43 pubmed publisher
    b>BNIP3 is a hypoxia-induced protein involved in cell death and survival but its role in human tumors is unclear. This study investigated the role of BNIP3 in prostate cancer...
  9. Murai M, Toyota M, Suzuki H, Satoh A, Sasaki Y, Akino K, et al. Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer. Clin Cancer Res. 2005;11:1021-7 pubmed
    b>BNIP3 protein is a proapoptotic member of the Bcl-2 family that is expressed in hypoxic regions of tumors...
  10. Chen G, Ray R, Dubik D, Shi L, Cizeau J, Bleackley R, et al. The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis. J Exp Med. 1997;186:1975-83 pubmed
    b>Nip3 (nineteen kD interacting protein-3) is an E1B 19K and Bcl-2 binding protein of unknown function...
  11. Mellor H, Rouschop K, Wigfield S, Wouters B, Harris A. Synchronised phosphorylation of BNIP3, Bcl-2 and Bcl-xL in response to microtubule-active drugs is JNK-independent and requires a mitotic kinase. Biochem Pharmacol. 2010;79:1562-72 pubmed publisher
    b>BNIP3 is a hypoxia-inducible BH3-only member of the Bcl-2 family of proteins that regulate apoptosis and autophagy. However the role of BNIP3 in the hypoxia response has proved difficult to define and remains controversial...
  12. Graham R, Thompson J, Wei J, Bishopric N, Webster K. Regulation of Bnip3 death pathways by calcium, phosphorylation, and hypoxia-reoxygenation. Antioxid Redox Signal. 2007;9:1309-15 pubmed
    b>Bnip3 is a proapoptotic member of the Bcl-2 family of death-regulating proteins that promote the intrinsic pathway of programmed cell death...
  13. Tan E, Campo L, Han C, Turley H, Pezzella F, Gatter K, et al. BNIP3 as a progression marker in primary human breast cancer; opposing functions in in situ versus invasive cancer. Clin Cancer Res. 2007;13:467-74 pubmed
    b>BNIP3 is involved in cell death and cell survival via autophagy. Its perinecrotic localization within ductal carcinoma in situ (DCIS) suggests an involvement in neoplastic cellular adaptation to low oxygen tension...
  14. Yan J, Yun H, Yang Y, Jing B, Feng C, Song bin F. Upregulation of BNIP3 promotes apoptosis of lung cancer cells that were induced by p53. Biochem Biophys Res Commun. 2006;346:501-7 pubmed
    ..The expression of pro-apoptotic gene BNIP3 was increased significantly both in Anip973 and 95D cell lines which have high metastasis ability, but not AGZY83-..
  15. Vande Velde C, Cizeau J, Dubik D, Alimonti J, Brown T, Israels S, et al. BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Mol Cell Biol. 2000;20:5454-68 pubmed
    ..b>BNIP3 (formerly NIP3) is a member of the Bcl-2 family that is expressed in mitochondria and induces apoptosis without a ..
  16. Zhu Y, Massen S, Terenzio M, Lang V, Chen Lindner S, Eils R, et al. Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. J Biol Chem. 2013;288:1099-113 pubmed publisher
    ..The BH3-only protein Bnip3 is an autophagy receptor that signals autophagic degradation of mitochondria (mitophagy) via interaction of its ..
  17. Bacon A, Fox S, Turley H, Harris A. Selective silencing of the hypoxia-inducible factor 1 target gene BNIP3 by histone deacetylation and methylation in colorectal cancer. Oncogene. 2007;26:132-41 pubmed
    ..However, proapoptotic pathways are also induced. BCL-2/adenovirus E1B-19 kDa-interacting protein 3 (BNIP3) represents a paradigm of a cell death protein that is hypoxically upregulated via HIF-1 in most cancers...
  18. Hanna R, Quinsay M, Orogo A, Giang K, Rikka S, Gustafsson A. Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy. J Biol Chem. 2012;287:19094-104 pubmed publisher
    ..b>Bnip3 is an atypical BH3-only protein that is known to cause mitochondrial dysfunction and cell death...
  19. Kothari S, Cizeau J, McMillan Ward E, Israels S, Bailes M, Ens K, et al. BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF. Oncogene. 2003;22:4734-44 pubmed
    Hypoxic regions within solid tumors are often resistant to chemotherapy and radiation. BNIP3 (Bcl-2/E1B 19 kDa interacting protein) is a proapoptotic member of the Bcl-2 family that is expressed in hypoxic regions of tumors...
  20. Burton T, Henson E, Baijal P, Eisenstat D, Gibson S. The pro-cell death Bcl-2 family member, BNIP3, is localized to the nucleus of human glial cells: Implications for glioblastoma multiforme tumor cell survival under hypoxia. Int J Cancer. 2006;118:1660-9 pubmed
    The Bcl-2 nineteen kilodalton interacting protein 3 (BNIP3) is a hypoxia-inducible proapoptotic member of the Bcl-2 family that induces cell death by associating with the mitochondria...
  21. Ray R, Chen G, Vande Velde C, Cizeau J, Park J, Reed J, et al. BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites. J Biol Chem. 2000;275:1439-48 pubmed
    b>BNIP3 (formerly NIP3) is a pro-apoptotic, mitochondrial protein classified in the Bcl-2 family based on limited sequence homology to the Bcl-2 homology 3 (BH3) domain and COOH-terminal transmembrane (TM) domain...
  22. Bruick R. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci U S A. 2000;97:9082-7 pubmed
    ..This study shows that transcription of the gene encoding Nip3, a proapoptotic member of the Bcl-2 family of cell death factors, is strongly induced in response to hypoxia...
  23. Pan Y, Luo Z, Zhuo M, Wei C, Chen G, Song Y. Oxidative stress and mitochondrial dysfunction mediated Cd-induced hepatic lipid accumulation in zebrafish Danio rerio. Aquat Toxicol. 2018;199:12-20 pubmed publisher
    ..level of genes (microtubule-associated protein light chain 3 alpha (lc3a), PTEN-induced putative kinase 1 (pink1), NIP3-like protein X (nix) and PARKIN (parkin)) related to mitophagy...
  24. Zhao X, Ma C, Li R, Xue J, Liu L, Liu P. Hypoxia Induces Apoptosis through HIF-1? Signaling Pathway in Human Uterosacral Ligaments of Pelvic Organ Prolapse. Biomed Res Int. 2017;2017:8316094 pubmed publisher
    ..The expression levels of HIF-1? and BNIP3 in the uterosacral ligaments were measured using immunohistochemistry, qRT-PCR, and Western blot...
  25. Aversa Z, Pin F, Lucia S, Penna F, Verzaro R, Fazi M, et al. Autophagy is induced in the skeletal muscle of cachectic cancer patients. Sci Rep. 2016;6:30340 pubmed publisher
    ..As for mitophagy, both Bnip3 and Nix/Bnip3L show a trend to increase in cachectic patients...
  26. Lyons A, Coleman M, Riis S, Favre C, O Flanagan C, Zhdanov A, et al. Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells. J Biol Chem. 2017;292:16983-16998 pubmed publisher
    ..dysfunction, indicated by reactive oxygen species expression, reduced expression of the mitophagy mediators BNIP3 and BNIP3L, and impaired mitophagy...
  27. Song C, Xu Q, Jiang K, Zhou G, Yu X, Wang L, et al. Inhibition of BMK1 pathway suppresses cancer stem cells through BNIP3 and BNIP3L. Oncotarget. 2015;6:33279-89 pubmed publisher
    ..RNA-seq and microarray analysis revealed that inhibition of BMK1 significantly enhanced the expression of BNIP3 and BNIP3L, which play important roles in cell death...
  28. Li H, Miao W, Ma J, Xv Z, Bo H, Li J, et al. Acute Exercise-Induced Mitochondrial Stress Triggers an Inflammatory Response in the Myocardium via NLRP3 Inflammasome Activation with Mitophagy. Oxid Med Cell Longev. 2016;2016:1987149 pubmed publisher
    ..Moreover, the mitochondrial autophagy-related proteins including Beclin1, LC3, and Bnip3 were all significantly upregulated during acute exercise, which suggests that mitophagy was stimulated in response ..
  29. Ria R, Todoerti K, Berardi S, Coluccia A, De Luisi A, Mattioli M, et al. Gene expression profiling of bone marrow endothelial cells in patients with multiple myeloma. Clin Cancer Res. 2009;15:5369-78 pubmed publisher
    ..Validation was focused on six genes (DIRAS3, SERPINF1, SRPX, BNIP3, IER3, and SEPW1) not previously found to be functionally correlated to the overangiogenic phenotype of multiple ..
  30. Wohlgemuth S, Lees H, Marzetti E, Manini T, Aranda J, Daniels M, et al. An exploratory analysis of the effects of a weight loss plus exercise program on cellular quality control mechanisms in older overweight women. Rejuvenation Res. 2011;14:315-24 pubmed publisher
    ..Changes in mRNA levels of FoxO3A and its targets MuRF1, MAFBx, and BNIP3 were on average seven-fold higher in the intervention group compared to controls, but these differences were not ..
  31. Bultman S, Holley D, G de Ridder G, Pizzo S, Sidorova T, Murray K, et al. BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo. Cardiovasc Pathol. 2016;25:258-269 pubmed publisher
    ..Mechanistically, increases in the autophagy and mitophagy-regulated proteins Beclin1 and Bnip3 were identified, paralleling changes seen in human heart failure...
  32. Yasuda M, Han J, Dionne C, Boyd J, Chinnadurai G. BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3. Cancer Res. 1999;59:533-7 pubmed
    ..Cellular protein BNIP3 is a BCL-2 family proapoptotic protein that interacts with viral antiapoptosis proteins such as adenoviruses E1B-..
  33. Hata T, Dal Molin M, Hong S, Tamura K, Suenaga M, Yu J, et al. Predicting the Grade of Dysplasia of Pancreatic Cystic Neoplasms Using Cyst Fluid DNA Methylation Markers. Clin Cancer Res. 2017;23:3935-3944 pubmed publisher
    ..154 validation) aspirated after surgical resection were analyzed for methylated DNA at selected genes (SOX17, BNIP3, FOXE1, PTCHD2, SLIT2, EYA4, and SFRP1) using methylation-specific droplet-digital PCR (dd-QMSP)...
  34. Ashokkumar R, Jamuna S, Sakeena Sadullah M, Niranjali Devaraj S. Vitexin protects isoproterenol induced post myocardial injury by modulating hipposignaling and ER stress responses. Biochem Biophys Res Commun. 2018;496:731-737 pubmed publisher
    ..by enhanced production of ROS, activation of caspase-3, modulation of Bcl2 family proteins and activation of bnip3. Moreover, post treatment with Vitexin inhibits the ISO induced translocation of CHOP to nucleus during MI...
  35. Chaanine A, Sreekumaran Nair K, Bergen R, Klaus K, Guenzel A, Hajjar R, et al. Mitochondrial Integrity and Function in the Progression of Early Pressure Overload-Induced Left Ventricular Remodeling. J Am Heart Assoc. 2017;6: pubmed publisher
    ..and impaired oxidative capacity with unique activation of mitochondrial autophagy and apoptosis markers (BNIP3 and Bax/Bcl-2)...
  36. Yoo N, Kim M, Park S, Seo S, Song S, Lee J, et al. Expression analysis of caspase-6, caspase-9 and BNIP3 in prostate cancer. Tumori. 2010;96:138-42 pubmed
    ..The aim of this study was to explore whether the expression of the proapoptotic proteins caspase-6, caspase-9, and Bcl-2/adenovirus E1B-19kDa-interacting protein3 (BNIP3) is altered in prostate cancers.
  37. Huang R, Quan Y, Chen J, Wang T, Xu M, Ye M, et al. Osteopontin Promotes Cell Migration and Invasion, and Inhibits Apoptosis and Autophagy in Colorectal Cancer by activating the p38 MAPK Signaling Pathway. Cell Physiol Biochem. 2017;41:1851-1864 pubmed publisher
    ..The ratios of proteins LC3-II/LC3-I, P62, and Atg7 were analyzed by Western-blot. Expressions of Beclin-1, Atg4b, Bnip3, and Vps34, both in transcriptional and translational levels, were analyzed and compared by RT-PCR and Western ..
  38. Alshudukhi A, Zhu J, Huang D, Jama A, Smith J, Wang Q, et al. Lipin-1 regulates Bnip3-mediated mitophagy in glycolytic muscle. FASEB J. 2018;:fj201800374 pubmed publisher
    ..suggest that lipin-1 participates in B-cell leukemia (BCL)-2 adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3)-regulated mitophagy by interacting with microtubule-associated protein 1A/1B-light chain (LC)3, which is an ..
  39. Kang C, Yeo D, Ji L. Muscle immobilization activates mitophagy and disrupts mitochondrial dynamics in mice. Acta Physiol (Oxf). 2016;218:188-197 pubmed publisher
    ..05) and parkin (approx. 70%; P < 0.05), were all increased by IM and remained activated after RM, whereas BNIP3 and PINK1 levels were decreased by IM (P < 0.05), but elevated upon RM (P < 0.01)...
  40. Xu W, Xu R, Li X, Zhang H, Wang X, Zhu J. Downregulating hypoxia-inducible factor-1? expression with perfluorooctyl-bromide nanoparticles reduces early brain injury following experimental subarachnoid hemorrhage in rats. Am J Transl Res. 2016;8:2114-26 pubmed
    ..In addition, it also suppressed the expression of HIF-1?, vascular endothelial growth factor (VEGF) and BNIP3 in the rat hippocampus. The effects of 10 g/kg PFOB were found to be more obvious than those of 5 g/kg PFOB...
  41. Gang H, Dhingra R, Wang Y, Mughal W, Gordon J, Kirshenbaum L. Epigenetic regulation of E2F-1-dependent Bnip3 transcription and cell death by nuclear factor-?B and histone deacetylase-1. Pediatr Cardiol. 2011;32:263-6 pubmed publisher
    ..the authors' laboratory identified a close relation between cell cycle factor E2F-1 and hypoxia-inducible factor Bnip3 as the key regulator of apoptosis and autophagy in ventricular myocytes...
  42. Tracy K, Macleod K. Regulation of mitochondrial integrity, autophagy and cell survival by BNIP3. Autophagy. 2007;3:616-9 pubmed
    Understanding the role of BNIP3 in the systemic response to hypoxia has been complicated by conflicting results that indicate on the one hand that BNIP3 promotes cell death, and other data, including our own that BNIP3 is not sufficient ..
  43. Ornelles D, Gooding L, Dickherber M, Policard M, Garnett Benson C. Limited but durable changes to cellular gene expression in a model of latent adenovirus infection are reflected in childhood leukemic cell lines. Virology. 2016;494:67-77 pubmed publisher
    ..BBS9, BNIP3, BTG3, CXADR, SLFN11 and SPARCL1 were the only genes differentially expressed between mock and infected B cells...
  44. Choi H, Merceron C, Mangiavini L, Seifert E, Schipani E, Shapiro I, et al. Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Autophagy. 2016;12:1631-46 pubmed publisher
    ..Noteworthy, while silencing of HIF1A affected hypoxic induction of BNIP3, it did not affect LC3-II levels, indicating hypoxia-induced autophagy is HIF1-independent...
  45. Lu J, Jiang Z, Chen Y, Zhou C, Chen C. Knockout of programmed cell death 5 (PDCD5) gene attenuates neuron injury after middle cerebral artery occlusion in mice. Brain Res. 2016;1650:152-161 pubmed publisher
    ..expression of hypoxia-inducible factor 1?(HIF-1?) and (BCL2/adenovirus E1B 19kDa protein-interacting protein 3) BNIP3. However, mice lacking PDCD5 had no changes in the expression of VHL and have slighter increases in the expression ..
  46. Zhao T, Tang X, Umeshappa C, Ma H, Gao H, Deng Y, et al. Simulated Microgravity Promotes Cell Apoptosis Through Suppressing Uev1A/TICAM/TRAF/NF-κB-Regulated Anti-Apoptosis and p53/PCNA- and ATM/ATR-Chk1/2-Controlled DNA-Damage Response Pathways. J Cell Biochem. 2016;117:2138-48 pubmed publisher
    ..Moreover, up- and down-regulation of pro-apoptotic (Caspases 3, 7, 8) and anti-apoptotic (Bcl2 and Bnip3) molecules was confirmed by Western blotting analysis...
  47. Bernard O, Jeny F, Uzunhan Y, Dondi E, Terfous R, Label R, et al. Mesenchymal stem cells reduce hypoxia-induced apoptosis in alveolar epithelial cells by modulating HIF and ROS hypoxic signalings. Am J Physiol Lung Cell Mol Physiol. 2017;:ajplung.00153.2017 pubmed publisher
    ..Expression of Bnip3 and CHOP, two pro-apoptotic targets of HIF-1? and ROS pathways, respectively, was suppressed by hMSC-CM while Bcl-..
  48. Lee S, Jeong E, Yoo N, Lee S. Mutational and expressional analysis of BNIP3, a pro-apoptotic Bcl-2 member, in gastric carcinomas. APMIS. 2007;115:1274-80 pubmed
    Cell death deregulation is a hallmark of human cancers. BNIP3 was initially identified as a pro-apoptotic member of the Bcl-2 family and plays an important role in apoptosis, necrosis and autophagy...
  49. Kataoka N, Ohno M, Moda I, Shimura Y. Identification of the factors that interact with NCBP, an 80 kDa nuclear cap binding protein. Nucleic Acids Res. 1995;23:3638-41 pubmed
    ..NIP1 and NIP2 have an RNP consensus-type RNA binding domain, whereas NIP3 contains a unique domain of Arg-Glu or Lys-Glu dipeptide repeats...
  50. Moriyama M, Moriyama H, Uda J, Kubo H, Nakajima Y, Goto A, et al. BNIP3 upregulation via stimulation of ERK and JNK activity is required for the protection of keratinocytes from UVB-induced apoptosis. Cell Death Dis. 2017;8:e2576 pubmed publisher
    ..Previously, we have demonstrated that BNIP3 stimulates autophagy in epidermal keratinocytes and has a protective effect in these cells upon UVB irradiation...
  51. Zamora R, Vodovotz Y, Betten B, Wong C, Zuckerbraun B, Gibson K, et al. Intestinal and hepatic expression of BNIP3 in necrotizing enterocolitis: regulation by nitric oxide and peroxynitrite. Am J Physiol Gastrointest Liver Physiol. 2005;289:G822-30 pubmed
    ..We examined the expression and regulation of the Bcl-2/adenovirus EIB 19-kDa-interacting protein 3 (BNIP3), a pro-apoptotic gene regulated by nitric oxide (NO) in hepatocytes, in NEC...
  52. Park C, Hong S, Kim E, Kwon J, Kim K, Nam H, et al. BNIP3 is degraded by ULK1-dependent autophagy via MTORC1 and AMPK. Autophagy. 2013;9:345-60 pubmed publisher
    b>BNIP3 (BCL2/adenovirus E1B 19 kDa interacting protein 3) is an atypical BH3-only protein that is induced by hypoxia-inducible factor 1 (HIF1) under hypoxia. BNIP3 is primarily regulated at the transcriptional level...
  53. Ishida M, Sunamura M, Furukawa T, Akada M, Fujimura H, Shibuya E, et al. Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis. World J Gastroenterol. 2007;13:4593-7 pubmed
    To evaluate the significance of BNIP3 in the pathogenesis of pancreatic cancer, we analyzed the relationship between the expression of BNIP3 and survival rate of the patients with pancreatic cancer, or chemosensitivities in pancreatic ..
  54. Zhong J, Huang R, Su Z, Zhang M, Xu M, Gong J, et al. Downregulation of miR-199a-5p promotes prostate adeno-carcinoma progression through loss of its inhibition of HIF-1?. Oncotarget. 2017;8:83523-83538 pubmed publisher
    ..mRNA, which reduced HIF-1? levels as well as downstream genes transactivated by HIF-1? (such as VEGF, CXCR4, BNIP3 and BCL-xL)...
  55. Kliminski V, Uziel O, Kessler Icekson G. Popdc1/Bves Functions in the Preservation of Cardiomyocyte Viability While Affecting Rac1 Activity and Bnip3 Expression. J Cell Biochem. 2017;118:1505-1517 pubmed publisher
    ..injury and death, upregulation of the pro-apoptotic protein Bcl-2/adenovirus E1B 19-kDa interacting protein3 (Bnip3), as well as reduction in Rac1-GTPase activity and in Akt phosphorylation...
  56. Iyalomhe O, Swierczek S, Enwerem N, Chen Y, Adedeji M, Allard J, et al. The Role of Hypoxia-Inducible Factor 1 in Mild Cognitive Impairment. Cell Mol Neurobiol. 2017;37:969-977 pubmed publisher
    ..On the other hand, prolonged or overwhelming stressors can convert HIF-1 into an activator of cell death through agents such as Bnip3, an event that is more likely to occur in late MCI or advanced Alzheimer's dementia.
  57. Xu Q, Junttila S, Scherer A, Giri K, Kivelä O, Skovorodkin I, et al. Renal carcinoma/kidney progenitor cell chimera organoid as a novel tumorigenesis gene discovery model. Dis Model Mech. 2017;10:1503-1515 pubmed publisher
    ..An efficient siRNA-mediated knockdown (KD) of Bnip3, Gsn, Lgals3, Pax8, Cav1, Egfr or Itgb2 gene expression was achieved ..
  58. Cleven A, Wouters B, Schutte B, Spiertz A, van Engeland M, de Bruine A. Poorer outcome in stromal HIF-2 alpha- and CA9-positive colorectal adenocarcinomas is associated with wild-type TP53 but not with BNIP3 promoter hypermethylation or apoptosis. Br J Cancer. 2008;99:727-33 pubmed publisher
    ..Therefore, we correlated apoptosis, TP53 mutational status and BNIP3 promoter hypermethylation of CRC cells with HIF-2 alpha- and CA9-related poor outcome...
  59. Liu F, Liu Q, Yang D, Bollag W, ROBERTSON K, Wu P, et al. Verticillin A overcomes apoptosis resistance in human colon carcinoma through DNA methylation-dependent upregulation of BNIP3. Cancer Res. 2011;71:6807-16 pubmed publisher
    ..induces cell-cycle arrest in the G? phase of the cell cycle in human colon carcinoma cells, markedly upregulating BNIP3 in both hepatoma and colon carcinoma cells...
  60. Chourasia A, Tracy K, Frankenberger C, Boland M, Sharifi M, Drake L, et al. Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis. EMBO Rep. 2015;16:1145-63 pubmed publisher
    b>BNip3 is a hypoxia-inducible protein that targets mitochondria for autophagosomal degradation. We report a novel tumor suppressor role for BNip3 in a clinically relevant mouse model of mammary tumorigenesis...
  61. Vereshaga Y, Volynsky P, Pustovalova J, Nolde D, Arseniev A, Efremov R. Specificity of helix packing in transmembrane dimer of the cell death factor BNIP3: a molecular modeling study. Proteins. 2007;69:309-25 pubmed
    b>BNIP3 is a mitochondrial 19-kDa proapoptotic protein, a member of the Bcl-2 family...
  62. Farrall A, Whitelaw M. The HIF1alpha-inducible pro-cell death gene BNIP3 is a novel target of SIM2s repression through cross-talk on the hypoxia response element. Oncogene. 2009;28:3671-80 pubmed publisher
    ..Microarray studies in prostate DU145 cells identified the pro-cell death gene, BNIP3 (Bcl-2/adenovirus E1B 19 kDa interacting protein 3), as a novel putative target of SIM2s repression...
  63. Zhang W, Zhao X, Xiao Y, Chen J, Han P, Zhang J, et al. The association of depressed angiogenic factors with reduced capillary density in the Rhesus monkey model of myocardial ischemia. Metallomics. 2016;8:654-62 pubmed publisher
    ..from primary cultures of neonatal rat cardiomyocytes also suppressed the expression of HIF-1 regulated VEGF and BNIP3, but not IGF-2...
  64. Wu Z, Zhao S, Li C, Liu C. LncRNA TUG1 serves an important role in hypoxia-induced myocardial cell injury by regulating the miR?145?5p?Binp3 axis. Mol Med Rep. 2018;17:2422-2430 pubmed publisher
    ..Furthermore, B?cell lymphoma 2 interacting protein 3 (Bnip3) was a target of miR?145?5p, and overexpression of Bnip3 aggravated hypoxia?induced cell injury by activating Wnt/?..
  65. Ikeda R, Tajitsu Y, Iwashita K, Che X, Yoshida K, Ushiyama M, et al. Thymidine phosphorylase inhibits the expression of proapoptotic protein BNIP3. Biochem Biophys Res Commun. 2008;370:220-4 pubmed publisher
    ..They also inhibited the upregulation of hypoxia-inducible factor (HIF) 1alpha and the proapoptotic factor, BNIP3, and caspase 3 activation induced by hypoxia...
  66. Li W, Hou G, Zhou D, Lou X, Xu Y, Liu S, et al. The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate induced esophageal squamous cell carcinoma cell death. Oncotarget. 2016;7:21542-55 pubmed publisher
    ..Moreover, the expression of autophagy inducers (Beclin, LC3II and BNIP3) and NDRG1 was significantly elevated in KYSE180 cells, but not in KYSE510 cells, after EDHB treatment...
  67. Romani B, Glashoff R, Engelbrecht S. Functional integrity of naturally occurring mutants of HIV-1 subtype C Vpr. Virus Res. 2010;153:288-98 pubmed publisher
    ..The natural mutations of Vpr may thus not always be regarded as defective mutations. The study suggests the adaptive role of the natural mutations commonly found in subtype C Vpr. ..
  68. Jurasz P, Yurkova N, Kirshenbaum L, Stewart D. VEGF masks BNIP3-mediated apoptosis of hypoxic endothelial cells. Angiogenesis. 2011;14:199-207 pubmed publisher
    ..neurons, and epithelial cells, through the actions of Bcl-2 and Nineteen kilodalton Interacting Protein-3 (BNIP3)...
  69. Stepan H, Leo C, Purz S, Hockel M, Horn L. Placental localization and expression of the cell death factors BNip3 and Nix in preeclampsia, intrauterine growth retardation and HELLP syndrome. Eur J Obstet Gynecol Reprod Biol. 2005;122:172-6 pubmed
    b>BNip3 and its homologue Nix are pro-apoptotic factors of the Bcl-2-family and are expressed in malignant tumors. In vitro, this expression was shown to be mediated by hypoxia...
  70. Ohi N, Tokunaga A, Tsunoda H, Nakano K, Haraguchi K, Oda K, et al. A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region. Cell Death Differ. 1999;6:314-25 pubmed
    ..B5 binds strongly to Nip3 and itself, weakly to E1B19K, but not to Bcl-2 and localizes in nuclear envelope, endoplasmic reticulum and ..
  71. Papandreou I, Lim A, Laderoute K, Denko N. Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L. Cell Death Differ. 2008;15:1572-81 pubmed publisher
    ..require nutrient deprivation, hypoxia-inducible factor-1 (HIF-1) activity, or expression of the HIF-1 target gene BNIP3 (Bcl-2 adenovirus E1a nineteen kilodalton interacting protein 3) or BNIP3L (BNIP3 like protein)...
  72. Cosse J, Rommelaere G, Ninane N, Arnould T, Michiels C. BNIP3 protects HepG2 cells against etoposide-induced cell death under hypoxia by an autophagy-independent pathway. Biochem Pharmacol. 2010;80:1160-9 pubmed publisher
    ..In this study, respective putative contribution of autophagy and BNIP3 in the protection conferred by hypoxia against the etoposide-induced apoptosis was investigated...
  73. Hong S, Omura N, Vincent A, Li A, Knight S, Yu J, et al. Genome-wide CpG island profiling of intraductal papillary mucinous neoplasms of the pancreas. Clin Cancer Res. 2012;18:700-12 pubmed publisher
    ..Several genes (BNIP3, PTCHD2, SOX17, NXPH1, EBF3) were significantly more likely to be methylated in IPMNs with high-grade than with ..
  74. Chen Y, Pandey S, Day C, Chen Y, Jiang A, Ho T, et al. Synergistic effect of HIF-1? and FoxO3a trigger cardiomyocyte apoptosis under hyperglycemic ischemia condition. J Cell Physiol. 2017;: pubmed publisher
    ..combined function of HIF-1? and FoxO3a under high glucose plus hypoxia condition lead to enhanced expression of BNIP3 inducing cardiomyocyte death...
  75. Dhingra A, Jayas R, Afshar P, Guberman M, Maddaford G, Gerstein J, et al. Ellagic acid antagonizes Bnip3-mediated mitochondrial injury and necrotic cell death of cardiac myocytes. Free Radic Biol Med. 2017;112:411-422 pubmed publisher
    The Bcl-2 protein Bnip3 is crucial for provoking oxidative injury to mitochondria following anthracycline treatment or ischemia-reperfusion injury...
  76. Hiraki M, Kitajima Y, Nakafusa Y, Nakamura J, Hashiguchi K, Sumi K, et al. CpG island methylation of BNIP3 predicts resistance against S-1/CPT-11 combined therapy in colorectal cancer patients. Oncol Rep. 2010;23:191-7 pubmed
    ..The gene methylation of CHFR, p16, RUNX3, E-cadherin, MGMT, hMLH1, ABCG2, UGT1A1 and BNIP3 genes were analyzed in 27 colorectal cancer tissues by quantitative methylation-specific PCR (q-MSP)...
  77. Choe S, Hamacher Brady A, Brady N. Autophagy capacity and sub-mitochondrial heterogeneity shape Bnip3-induced mitophagy regulation of apoptosis. Cell Commun Signal. 2015;13:37 pubmed publisher
    ..The BH3-only protein Bnip3 integrates apoptosis and mitophagy signaling at different signaling domains...
  78. Divyya S, Naushad S, Murthy P, Reddy C, Kutala V. GCPII modulates oxidative stress and prostate cancer susceptibility through changes in methylation of RASSF1, BNIP3, GSTP1 and Ec-SOD. Mol Biol Rep. 2013;40:5541-50 pubmed publisher
    ..In the current study, we have elucidated the impact of these haplotypes on the expression of PSMA, BNIP3, Ec-SOD, GSTP1 and RASSF1 genes to understand the epigenetic basis of oxidative stress and prostate cancer risk...
  79. Naushad S, Prayaga A, Digumarti R, Gottumukkala S, Kutala V. Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) expression is epigenetically regulated by one-carbon metabolism in invasive duct cell carcinoma of breast. Mol Cell Biochem. 2012;361:189-95 pubmed publisher
    ..of expression and CpG island methylator phenotype (CIMP) of Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) in invasive duct cell carcinoma (IDC), we hypothesized in this article that impaired one-carbon metabolism might ..