Gene Symbol: BMPR1B
Description: bone morphogenetic protein receptor type 1B
Alias: ALK-6, ALK6, AMDD, BDA1D, BDA2, CDw293, bone morphogenetic protein receptor type-1B, BMP type-1B receptor, BMPR-1B, activin receptor-like kinase 6, bone morphogenetic protein receptor, type IB, serine/threonine receptor kinase
Species: human
Products:     BMPR1B

Top Publications

  1. Lehmann K, Seemann P, Stricker S, Sammar M, Meyer B, Süring K, et al. Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2. Proc Natl Acad Sci U S A. 2003;100:12277-82 pubmed
    ..This interval includes the gene bone morphogenetic protein receptor 1B (BMPR1B), a type I transmembrane serinethreonine kinase...
  2. Saetrom P, Biesinger J, Li S, Smith D, Thomas L, Majzoub K, et al. A risk variant in an miR-125b binding site in BMPR1B is associated with breast cancer pathogenesis. Cancer Res. 2009;69:7459-65 pubmed publisher
    ..that resides within a miR-125b target site in the 3' untranslated region of the bone morphogenic receptor type 1B (BMPR1B) gene encoding a transmembrane serine/threonine kinase...
  3. Howe J, Sayed M, Ahmed A, Ringold J, Larsen Haidle J, Merg A, et al. The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations. J Med Genet. 2004;41:484-91 pubmed
    ..A total of 77 JP cases were sequenced for mutations in the MADH4, BMPR1A, BMPR1B, BMPR2, and/or ACVR1 (activin A receptor) genes...
  4. Seemann P, Schwappacher R, Kjaer K, Krakow D, Lehmann K, Dawson K, et al. Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2. J Clin Invest. 2005;115:2373-81 pubmed
    ..and symphalangism (R438L), conditions previously associated with mutations in the GDF5 receptor bone morphogenetic protein receptor type 1b (BMPR1B) and the BMP antagonist NOGGIN, respectively...
  5. Liu S, Tian Z, Yin F, Zhang P, W Y, Ding X, et al. Expression and functional roles of Smad1 and BMPR-IB in glioma development. Cancer Invest. 2009;27:734-40 pubmed publisher
    ..The effects could be blocked by cotransfection of Smad6. These results might provide new molecular marker and target for glioma diagnosis and therapy. ..
  6. Schwaerzer G, Hiepen C, Schrewe H, Nickel J, Ploeger F, Sebald W, et al. New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance. J Bone Miner Res. 2012;27:429-42 pubmed publisher
    ..The detailed molecular characterization of GDF5-S94N as a noggin-resistant growth factor illustrates the potential of GDF5 mutants in applications with defined therapeutical needs...
  7. Laperrousaz B, Jeanpierre S, Sagorny K, Voeltzel T, Ramas S, Kaniewski B, et al. Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpression. Blood. 2013;122:3767-77 pubmed publisher
    ..These results provide new insights with regard to leukemic stem cell biology and suggest possibilities for the development of novel therapeutic tools specifically targeting the CML niche. ..
  8. Bokobza S, Ye L, Kynaston H, Mansel R, Jiang W. Reduced expression of BMPR-IB correlates with poor prognosis and increased proliferation of breast cancer cells. Cancer Genomics Proteomics. 2009;6:101-8 pubmed
    ..This suggests that BMPR-IB mediates an inhibitory effect on breast cancer cells. ..
  9. Yamaji N, Celeste A, Thies R, Song J, Bernier S, Goltzman D, et al. A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem Biophys Res Commun. 1994;205:1944-51 pubmed
    ..During embryogenesis, in situ hybridization analysis indicates that CFK-43a mRNA is localized in developing skeletal tissues in a complementary fashion to the transcripts for its ligands. ..

More Information

Publications177 found, 100 shown here

  1. Keller S, Nickel J, Zhang J, Sebald W, Mueller T. Molecular recognition of BMP-2 and BMP receptor IA. Nat Struct Mol Biol. 2004;11:481-8 pubmed
    ..Thus, the L51P substitution converts BMP-2 into a receptor-inactive inhibitor of noggin. These results are relevant for other proteins of the TGF-beta superfamily and provide useful clues for structure-based drug design. ..
  2. Kotzsch A, Nickel J, Seher A, Sebald W, Müller T. Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity. EMBO J. 2009;28:937-47 pubmed publisher
    ..The new structural data now provide also a molecular basis of how phenotypically relevant missense mutations in GDF-5 might impair receptor binding and activation. ..
  3. Yamada N, Kato M, ten Dijke P, Yamashita H, Sampath T, Heldin C, et al. Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours. Br J Cancer. 1996;73:624-9 pubmed
    ..These results suggest the presence of BMP receptors and a functional role for BMPs in malignant glioma. ..
  4. Chen D, Zhao M, Mundy G. Bone morphogenetic proteins. Growth Factors. 2004;22:233-41 pubmed
    ..A significant advancement about the understanding of in vivo functions of BMP ligands, receptors and signaling molecules has been achieved in recent years. ..
  5. Ma Y, Ma L, Guo Q, Zhang S. Expression of bone morphogenetic protein-2 and its receptors in epithelial ovarian cancer and their influence on the prognosis of ovarian cancer patients. J Exp Clin Cancer Res. 2010;29:85 pubmed publisher
    ..BMP-2, BMPRIB, and BMPRII exhibited low expression in EOC tissue, and variation or loss of expression may indicate poor prognosis for ovarian cancer patients. ..
  6. Pauk M, Bordukalo Niksic T, Brkljacic J, Paralkar V, Brault A, Dumic Cule I, et al. A novel role of bone morphogenetic protein 6 (BMP6) in glucose homeostasis. Acta Diabetol. 2019;56:365-371 pubmed publisher
    ..BMP6 acted on pancreatic and liver cells utilizing Alk3, Alk6 and ActRIIA serine/threonine kinase receptors...
  7. Shi W, Wang H, Zheng X, Jiang X, Xu Z, Shen H, et al. HNF-4alpha Negatively Regulates Hepcidin Expression Through BMPR1A in HepG2 Cells. Biol Trace Elem Res. 2017;176:294-304 pubmed publisher
    ..BMPR1A, but not BMPR1B, BMPR2, ActR2A, ActR2B, or HJV, was decreased by HNF-4?, and HNF4?-knockdown-induced stimulation of hepcidin could ..
  8. Shen H, Gelberman R, Silva M, Sakiyama Elbert S, Thomopoulos S. BMP12 induces tenogenic differentiation of adipose-derived stromal cells. PLoS ONE. 2013;8:e77613 pubmed publisher
    ..Moreover, ALK6 was found to be the most abundant type I receptor in ASCs, with mRNA expression 100 to 10,000 times that of any ..
  9. Zhang Y, Gou W, Ma J, Zhang H, Zhang Y, Zhang H. Genome methylation and regulatory functions for hypoxic adaptation in Tibetan chicken embryos. Peerj. 2017;5:e3891 pubmed publisher
    ..Five candidate genes that had low methylation (EDNRA, EDNRB2, BMPR1B, BMPRII, and ITGA2) might play key regulatory roles in the adaptation to hypoxia in Tibetan ..
  10. Richards E, El Nashar S, Schoolmeester J, Keeney G, Mariani A, Hopkins M, et al. Abnormal Uterine Bleeding Is Associated With Increased BMP7 Expression in Human Endometrium. Reprod Sci. 2017;24:671-681 pubmed publisher
    ..However, expression of BMPR1A, BMPR1B, and SMAD4 was significantly decreased in cancer compared to benign samples...
  11. Ciller I, Palanisamy S, Ciller U, McFarlane J. Postnatal expression of bone morphogenetic proteins and their receptors in the mouse testis. Physiol Res. 2016;65:673-682 pubmed
    ..All three BMP receptor mRNAs - Bmpr1a, Bmpr1b and Bmpr2, and ten BMP mRNAs - Bmp2, Bmp3, Bmp3b, Bmp4, Bmp5, Bmp6, Bmp7, Bmp8a, Bmp8b and Bmp15 were expressed in ..
  12. Kamalludin M, Guerra A, Wiltbank M, Kirkpatrick B. Trio, a novel high fecundity allele: I. Transcriptome analysis of granulosa cells from carriers and non-carriers of a major gene for bovine ovulation rate. Biol Reprod. 2017;: pubmed publisher
    ..of SMAD6, an inhibitor of the BMP/SMAD signaling pathway, with high ovulation rate corresponds well with disabling mutations in ligands (BMP15, GDF9) and a receptor (BMPR1B) of this pathway that cause increased ovulation rate in sheep.
  13. Olsen O, Wader K, Hella H, Mylin A, Turesson I, Nesthus I, et al. Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B. Cell Commun Signal. 2015;13:27 pubmed publisher
    ..ACVR2A and ACVR2B in combination with ALK2, but not BMPs that signal through BMPR2 in combination with ALK3 and ALK6. We propose that one important way that activin A regulates cell behavior is by antagonizing BMP-ACVR2A/ACVR2B/ALK2 ..
  14. Huo Y, Su T, Cai Q, Macara I. An In Vivo Gain-of-Function Screen Identifies the Williams-Beuren Syndrome Gene GTF2IRD1 as a Mammary Tumor Promoter. Cell Rep. 2016;15:2089-2096 pubmed publisher
    ..The mis-regulation of genes downstream of GTF2IRD1, including T?R2 and BMPR1b, also individually promoted mammary cancer development, and silencing of T?R2 suppressed GTF2IRD1-driven tumor ..
  15. Madhu V, Kilanski A, Reghu N, Dighe A, Cui Q. Expression of CD105 and CD34 receptors controls BMP-induced in vitro mineralization of mouse adipose-derived stem cells but does not predict their in vivo bone-forming potential. J Orthop Res. 2015;33:625-32 pubmed publisher
    ..CD105(+) CD34(-) population displayed higher gene expression of Alk1 or Alk6 receptors in comparison with other populations...
  16. Wei F, Chen J, Chen X, Bao B. Comparative analysis of the neurula transcriptomes of two species of flatfishes: Platichthys stellatus and Paralichthys olivaceus. Gene. 2017;596:147-153 pubmed publisher
    ..stellatus did not exist in P. olivaceus. Fifty-one SNPs were identified in nine genes (Fgf7, Wnt9, Sfrp2, Bmpr1B, Bmpr2, Pax3, Pax6, Six1 and Tgf?r2) related to eye development. In particular, Tgf?r2 with Asp77Glu found in P...
  17. Seroussi E, Rosov A, Shirak A, Lam A, Gootwine E. Unveiling genomic regions that underlie differences between Afec-Assaf sheep and its parental Awassi breed. Genet Sel Evol. 2017;49:19 pubmed publisher
    ..Because the Afec-Assaf strain, but not the Awassi breed, carries the Booroola mutation, association analysis of BMPR1B used as the test gene was performed to evaluate the ability of this study to identify a VGR that includes such a ..
  18. Parks W, Frank D, Huff C, Renfrew Haft C, Martin J, Meng X, et al. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. J Biol Chem. 2001;276:19332-9 pubmed
    ..These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases. ..
  19. Madhu V, Li C, Dighe A, Balian G, Cui Q. BMP-non-responsive Sca1+ CD73+ CD44+ mouse bone marrow derived osteoprogenitor cells respond to combination of VEGF and BMP-6 to display enhanced osteoblastic differentiation and ectopic bone formation. PLoS ONE. 2014;9:e103060 pubmed publisher
    ..The lack of CD105, Alk1 and Alk6 expression in D1 cells correlated with poor response to BMPs indicating that a greater care in the selection of ..
  20. Regan S, Knight P, Yovich J, Arfuso F, Dharmarajan A. Growth hormone during in vitro fertilization in older women modulates the density of receptors in granulosa cells, with improved pregnancy outcomes. Fertil Steril. 2018;110:1298-1310 pubmed publisher
    ..the granulosal expression density of FSH receptor (FSHR), LH receptor (LHR), bone morphogenetic hormone receptor (BMPR1B), and GHR...
  21. Hirschhorn T, Levi Hofman M, Danziger O, Smorodinsky N, Ehrlich M. Differential molecular regulation of processing and membrane expression of Type-I BMP receptors: implications for signaling. Cell Mol Life Sci. 2017;74:2645-2662 pubmed publisher
    The Type-I bone morphogenetic protein receptors (BMPRs), BMPR1A and BMPR1B, present the highest sequence homology among BMPRs, suggestive of functional similitude...
  22. Wang S, Hu S, Wang J, Liu Y, Zhao R, Tong M, et al. Conditioned medium from bone marrow-derived mesenchymal stem cells inhibits vascular calcification through blockade of the BMP2-Smad1/5/8 signaling pathway. Stem Cell Res Ther. 2018;9:160 pubmed publisher
    ..Expression of BMP2, BMPR1A, BMPR1B, BMPR2, msh homeobox 2 (Msx2), Runt-related transcription factor 2 (Runx2), and osteocalcin (OC), representative ..
  23. Regan S, McFarlane J, O Shea T, Andronicos N, Arfuso F, Dharmarajan A, et al. Flow cytometric analysis of FSHR, BMRR1B, LHR and apoptosis in granulosa cells and ovulation rate in merino sheep. Reproduction. 2015;150:151-63 pubmed publisher
    ..up-regulation of FSH receptor (FSHR), transforming growth factor beta type 1, bone morphogenetic protein receptor (BMPR1B), and LH receptor (LHR) in BB sheep...
  24. Moore R, Otsuka F, Shimasaki S. Molecular basis of bone morphogenetic protein-15 signaling in granulosa cells. J Biol Chem. 2003;278:304-10 pubmed
  25. Shi W, Chang C, Nie S, Xie S, Wan M, Cao X. Endofin acts as a Smad anchor for receptor activation in BMP signaling. J Cell Sci. 2007;120:1216-24 pubmed
    ..Taken together, our results suggest that endofin plays an important role in both positive and negative feedback regulation of the BMP signaling pathway. ..
  26. Yeung S, Tong J, Law P, Chung L, Lung R, Tong C, et al. Profiling of Oncogenic Driver Events in Lung Adenocarcinoma Revealed MET Mutation as Independent Prognostic Factor. J Thorac Oncol. 2015;10:1292-1300 pubmed publisher
    ..High negative predictive values of thyroid transcription factor-1 and MET expression suggest potential roles as surrogate markers for EGFR and/or MET mutations. ..
  27. Liang X, Briaux A, Becette V, Benoist C, Boulai A, Chemlali W, et al. Molecular profiling of hormone receptor-positive, HER2-negative breast cancers from patients treated with neoadjuvant endocrine therapy in the CARMINA 02 trial (UCBG-0609). J Hematol Oncol. 2018;11:124 pubmed publisher
    ..This trial is registered with ( NCT00629616 ) on March 6, 2008, retrospectively registered. ..
  28. Rajesh G, Paul A, Mishra S, Bharati J, Thakur N, Mondal T, et al. Expression and functional role of Bone Morphogenetic Proteins (BMPs) in cyclical corpus luteum in buffalo (Bubalus bubalis). Gen Comp Endocrinol. 2017;240:198-213 pubmed publisher
    ..The qPCR, immunoblot and immunohistochemistry studies revealed that BMP2 and BMP Receptors (BMPR1A, BMPR1B and BMPR2) were significantly upregulated during the mid stage whereas BMP4 and BMP7 were upregulated during the ..
  29. Tang J, Hu W, DI R, Liu Q, Wang X, Zhang X, et al. Expression Analysis of the Prolific Candidate Genes, BMPR1B, BMP15, and GDF9 in Small Tail Han Ewes with Three Fecundity (FecB Gene) Genotypes. Animals (Basel). 2018;8: pubmed publisher
    The expression characteristics of the prolific candidate genes, BMPR1B, BMP15, and GDF9, in the major visceral organs and hypothalamic⁻pituitary⁻gonadal (HPG) axis tissues of three FecB genotypes (FecB BB, ..
  30. Itoh F, Asao H, Sugamura K, Heldin C, ten Dijke P, Itoh S. Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads. EMBO J. 2001;20:4132-42 pubmed
    ..The data strongly suggest that the molecular mechanism by which AMSH exerts its action is by inhibiting the binding of Smad6 to activated type I receptors or activated R-Smads. ..
  31. Nakase T, Myoui A, Shimada K, Kuriyama K, Joyama S, Miyaji T, et al. Involvement of BMP-2 signaling in a cartilage cap in osteochondroma. J Orthop Res. 2001;19:1085-8 pubmed
    ..This is the first study to provide observational evidence of the involvement of BMP-2 signaling in the pathogenesis of cartilage cap of osteochondroma. and suggests the role of BMP-2 in the growth of cartilage cap in osteochondroma. ..
  32. Kjaer K, Eiberg H, Hansen L, van der Hagen C, Rosendahl K, Tommerup N, et al. A mutation in the receptor binding site of GDF5 causes Mohr-Wriedt brachydactyly type A2. J Med Genet. 2006;43:225-31 pubmed
    ..BDA2 was first described by Mohr and Wriedt in a large Danish/Norwegian kindred and mutations in BMPR1B were recently demonstrated in two affected families.
  33. Ye L, Lewis Russell J, Davies G, Sanders A, Kynaston H, Jiang W. Hepatocyte growth factor up-regulates the expression of the bone morphogenetic protein (BMP) receptors, BMPR-IB and BMPR-II, in human prostate cancer cells. Int J Oncol. 2007;30:521-9 pubmed
    ..This may have important implications in the development of bone metastasis in prostate cancer. ..
  34. Xu H, Qi Y, Dun S, Gao Y, Qiu X. [BMP7 signaling via BMPR1A, BMPR1B inhibits the proliferation of lung large carcinoma NCI-H460 cell]. Zhongguo Fei Ai Za Zhi. 2010;13:659-64 pubmed publisher
    ..Blocking endogenous BMPR1A, BMPR1B obviously reversed the inhibition of BMP7 on the proliferation of NCI-H460 cell respectively (P = 0.003, P = 0...
  35. Varadaraj A, Patel P, Serrao A, Bandyopadhay T, Lee N, Jazaeri A, et al. Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia. Neoplasia. 2015;17:826-38 pubmed publisher
    ..complex formation between the type I receptor serine threonine kinases activin receptor-like kinase (ALK) 3 and ALK6 and the type II receptor serine threonine kinase BMPRII...
  36. Ruschke K, Meier C, Ullah M, Krebs A, Silberreis K, Kohl B, et al. Bone morphogenetic protein 2/SMAD signalling in human ligamentocytes of degenerated and aged anterior cruciate ligaments. Osteoarthritis Cartilage. 2016;24:1816-1825 pubmed publisher
    ..Degeneration correlated significantly with synovitis. ACL fibroblasts expressed BMP type I receptors ALK3 and ALK6 and the BMP type II receptor BMPRII...
  37. Raines A, Magella B, Adam M, Potter S. Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development. BMC Dev Biol. 2015;15:28 pubmed publisher
    ..In addition of the Hox mutants showed strongly altered expression of Pknox2, Zfp467, Gdf5, Bmpr1b, Dkk3, Igf1, Hand2, Shox2, Runx3, Bmp7 and Lef1, all of which have been previously shown to play important roles ..
  38. Agarwal S, Loder S, Breuler C, Li J, Cholok D, Brownley C, et al. Strategic Targeting of Multiple BMP Receptors Prevents Trauma-Induced Heterotopic Ossification. Mol Ther. 2017;25:1974-1987 pubmed publisher
    ..Here we show that, although BMP signaling is required for tHO, no single T1-BMPR (ACVR1/ALK2, BMPR1a/ALK3, or BMPR1b/ALK6) alone is necessary for this disease, suggesting that these receptors have functional redundancy in the ..
  39. Feng N, Xu B, Tao J, Li P, Cheng G, Min Z, et al. A miR-125b binding site polymorphism in bone morphogenetic protein membrane receptor type IB gene and prostate cancer risk in China. Mol Biol Rep. 2012;39:369-73 pubmed publisher
    ..binding site in the 3' untranslated region (3'UTR) of bone morphogenetic protein membrane receptor type IB gene (BMPR1B) has been found to contribute to cancer susceptibility...
  40. Allison S, Chen Y, Petrovic N, Zimmermann S, Moosmann B, Jansch M, et al. Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2. Int J Biochem Cell Biol. 2016;80:173-178 pubmed publisher
    ..From gene ontology pathway analysis bone morphogenetic protein (BMP) receptor 1B (BMPR1B) emerged as an important upregulated gene in MDA-2J2 cells...
  41. Regan S, Knight P, Yovich J, Stanger J, Leung Y, Arfuso F, et al. The effect of ovarian reserve and receptor signalling on granulosa cell apoptosis during human follicle development. Mol Cell Endocrinol. 2018;470:219-227 pubmed publisher
    ..IVF patients, the level of apoptosis was inversely proportional to the expression of bone morphogenetic protein (BMPR1B) and follicle stimulating hormone (FSH) receptors...
  42. Patiño L, Beau I, Carlosama C, Buitrago J, Gonzalez R, Suárez C, et al. New mutations in non-syndromic primary ovarian insufficiency patients identified via whole-exome sequencing. Hum Reprod. 2017;32:1512-1520 pubmed publisher
    ..Mutations in BMPR1B and GREM1 were modeled by using fragment molecular orbital analysis...
  43. Zhang Y, Wester L, He J, Geiger T, Moerkens M, Siddappa R, et al. IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer. Oncogene. 2018;37:1869-1884 pubmed publisher
    ..These include the tamoxifen resistance suppressors BMPR1B, CDK10, CDK5, EIF2AK1, and MAP2K5, and the tamoxifen resistance inducers CHEK1, PAK2, RPS6KC1, TTK, and TXK...
  44. Díaz P, Hein G, Belotti E, Rodríguez F, Rey F, Amweg A, et al. BMP2, 4 and 6 and BMPR1B are altered from early stages of bovine cystic ovarian disease development. Reproduction. 2016;152:333-50 pubmed publisher
    ..Therefore, we examined the expression of BMP2, BMP4 and BMP6 and BMP receptor 1B (BMPR1B) in the ovaries of animals with spontaneous or ACTH-induced COD, as well as during the development of the disease, ..
  45. Yao H, Li H, Yang S, Li M, Zhao C, Zhang J, et al. Inhibitory Effect of Bone Morphogenetic Protein 4 in Retinal Pigment Epithelial-Mesenchymal Transition. Sci Rep. 2016;6:32182 pubmed publisher
    ..Moreover, the mRNA and protein expression levels of BMP4 were decreased whereas BMP4 receptors ALK2, ALK3 and ALK6 were increased during TGF-?-induced EMT in primary RPE cells...
  46. Nio Kobayashi J, Trendell J, Giakoumelou S, Boswell L, Nicol L, Kudo M, et al. Bone morphogenetic proteins are mediators of luteolysis in the human corpus luteum. Endocrinology. 2015;156:1494-503 pubmed publisher
    ..05-.001) and in vitro (P<.001), and decreased the mRNA abundance of BMP receptors (BMPR1A, BMPR1B, BMPR2; P<.05-.01) in vitro. Three BMPs were regulated by differential signaling pathways...
  47. Chen H, Liu C, Jiang H, Gao Y, Xu M, Wang J, et al. Regulatory Role of miRNA-375 in Expression of BMP15/GDF9 Receptors and its Effect on Proliferation and Apoptosis of Bovine Cumulus Cells. Cell Physiol Biochem. 2017;41:439-450 pubmed publisher
    ..The BMP15/GDF9 heterodimer needs to bind to the BMPR2-ALK4/5/7-ALK6 receptor complex to activate the SMAD2/3 signaling pathway...
  48. Yang Y, Yuan J, Yao X, Zhang R, Yang H, Zhao R, et al. BMPR1B mutation causes Pierre Robin sequence. Oncotarget. 2017;8:25864-25871 pubmed publisher
    ..We hypothesized that PRS in this family was caused by (i) haploinsufficiency for BMPR1B or (ii) a gain of function mechanism mediated by the BMPR1B-GRM4 fusion gene...
  49. Liu C, Yuan B, Chen H, Xu M, Sun X, Xu J, et al. Effects of MiR-375-BMPR2 as a Key Factor Downstream of BMP15/GDF9 on the Smad1/5/8 and Smad2/3 Signaling Pathways. Cell Physiol Biochem. 2018;46:213-225 pubmed publisher
    ..changes before and after transfection in the expression levels of the BMP15/GDF9 type I receptors ALK4, ALK5 and ALK6; the phosphorylation levels of Smad2/3 and Smad1/5/8, which are key signaling pathway proteins downstream of BMP15/..
  50. Liu Z, Shen J, Pu K, Katus H, Plöger F, Tiefenbacher C, et al. GDF5 and BMP2 inhibit apoptosis via activation of BMPR2 and subsequent stabilization of XIAP. Biochim Biophys Acta. 2009;1793:1819-27 pubmed publisher
    ..We conclude that the inhibition of apoptosis in mouse embryonic fibroblasts by BMP2 and GDF5 does not depend on more complex signal transduction pathways such as smad and MAPK signaling but on direct stabilization of XIAP by BMPR2. ..
  51. Regan S, Knight P, Yovich J, Stanger J, Leung Y, Arfuso F, et al. Infertility and ovarian follicle reserve depletion are associated with dysregulation of the FSH and LH receptor density in human antral follicles. Mol Cell Endocrinol. 2017;446:40-51 pubmed publisher
    ..This was reversed in the older patients with poor ovarian reserve. The strong correlation of BMPR1B and FSH receptor density in the young was not present in the older women; whereas, the LH receptor and BMPR1B ..
  52. Li W, Zhang M, Li Q, Tang H, Zhang L, Wang K, et al. Whole-genome resequencing reveals candidate mutations for pig prolificacy. Proc Biol Sci. 2017;284: pubmed publisher
    ..response element (ERE) within the first intron of the bone morphogenetic protein receptor type-1B gene (BMPR1B) that overlaps with a known quantitative trait locus (QTL) for pig fecundity...
  53. Yin H, Zhou Q, Panda M, Yeh L, Zavala M, Lee J. A fluorescence study of type I and type II receptors of bone morphogenetic proteins with bis-ANS (4, 4'-dianilino-1, 1'-bisnaphthyl-5, 5' disulfonic acid). Biochim Biophys Acta. 2007;1774:493-501 pubmed
    ..These results show that the bis-ANS-modified hydrophobic site on the ecBMPR-IB and -II molecules plays a different functional role. ..
  54. Roman B, Hinck A. ALK1 signaling in development and disease: new paradigms. Cell Mol Life Sci. 2017;74:4539-4560 pubmed publisher
  55. Wu X, Wang Y, Wu Q, Cheng W, Liu W, Zhao Y, et al. HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression. Blood. 2014;124:1335-43 pubmed publisher
    ..Our results provide evidence that HFE induces hepcidin expression via the BMP pathway: HFE interacts with ALK3 to stabilize ALK3 protein and increase ALK3 expression at the cell surface. ..
  56. García E, Hamdi M, Barrera A, Sánchez Calabuig M, Gutiérrez Adán A, Rizos D. Bovine embryo-oviduct interaction in vitro reveals an early cross talk mediated by BMP signaling. Reproduction. 2017;153:631-643 pubmed publisher
    ..Exposure to embryos, irrespective of the period, significantly reduced the relative abundance of BMPR1B, BMPR2, SMAD1, SMAD6 and ID2 mRNAs in BOEC...
  57. Workman A, Zhu L, Keel B, Smith T, Jones C. The Wnt Signaling Pathway Is Differentially Expressed during the Bovine Herpesvirus 1 Latency-Reactivation Cycle: Evidence That Two Protein Kinases Associated with Neuronal Survival, Akt3 and BMPR2, Are Expressed at Higher Levels during Latency. J Virol. 2018;92: pubmed publisher
    ..These findings provide insight into how cellular factors associated with the Wnt signaling pathway cooperate with LR gene products to regulate the BoHV-1 latency-reactivation cycle. ..
  58. Abdoli R, Ziaeddin Mirhoseini S, Ghavi Hossein Zadeh N, Zamani P. Screening for Causative Mutations of Major Prolificacy Genes in Iranian Fat-Tailed Sheep. Int J Fertil Steril. 2018;12:51-55 pubmed publisher
    ..of different missense mutations in sheep breeds have shown that the bone morphogenetic protein receptor 1B (BMPR1B), bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) genes play a vital role in ..
  59. Souza C, MacDougall C, Campbell B, McNeilly A, Baird D. The Booroola (FecB) phenotype is associated with a mutation in the bone morphogenetic receptor type 1 B (BMPR1B) gene. J Endocrinol. 2001;169:R1-6 pubmed
    ..The BMPR1B gene in the human is located at the region linked with the Booroola mutation, syntenic to chromosome 6 in the ..
  60. Chang C, Chen Y, Lai M, Chang H, Cheng J, Chan C, et al. BMPR1B up-regulation via a miRNA binding site variation defines endometriosis susceptibility and CA125 levels. PLoS ONE. 2013;8:e80630 pubmed publisher
    Bone morphogenetic protein receptor I B (BMPR1B) is a transmembrane receptor mediating TGF-? signal transduction. Recent studies indicate a tumor suppressor role for BMPR1B in ovarian cancer...
  61. Rajesh G, Mishra S, Paul A, Punetha M, Vidyalakshmi G, Narayanan K, et al. Transcriptional and translational abundance of Bone morphogenetic protein (BMP) 2, 4, 6, 7 and their receptors BMPR1A, 1B and BMPR2 in buffalo ovarian follicle and the role of BMP4 and BMP7 on estrogen production and survival of cultured granulosa ce. Res Vet Sci. 2018;118:371-388 pubmed publisher
    ..buffalo, the present study was aimed to investigate the expression of BMP2, 4, 6, 7 and their receptors BMPR1A, BMPR1B, BMPR2 in the GC and theca cells (TC) of ovarian follicles and the role of BMP4 and BMP7 on buffalo GC...
  62. Schrock A, Zhu V, Hsieh W, Madison R, Creelan B, Silberberg J, et al. Receptor Tyrosine Kinase Fusions and BRAF Kinase Fusions are Rare but Actionable Resistance Mechanisms to EGFR Tyrosine Kinase Inhibitors. J Thorac Oncol. 2018;13:1312-1323 pubmed publisher
    ..Detection of RTK and BRAF fusions should be part of comprehensive profiling panels to determine resistance to EGFR TKIs and direct appropriate combination therapeutic strategies. ..
  63. Liu F, Ventura F, Doody J, Massague J. Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol Cell Biol. 1995;15:3479-86 pubmed
    ..The combinatorial nature of these receptors and their capacity to crosstalk with the activin receptor system may underlie the multifunctional nature of their ligands. ..
  64. Serrano M, Liu J, Svoboda K, Nawshad A, Benson M. Ephrin reverse signaling mediates palatal fusion and epithelial-to-mesenchymal transition independently of Tgfß3. J Cell Physiol. 2015;230:2961-72 pubmed publisher
    ..These data reveal that ephrin reverse signaling directs palatal fusion in mammals through a mechanism that involves EMT but not apoptosis and activates a gene expression program not previously associated with ephrin reverse signaling. ..
  65. ten Dijke P, Yamashita H, Ichijo H, Franzen P, Laiho M, Miyazono K, et al. Characterization of type I receptors for transforming growth factor-beta and activin. Science. 1994;264:101-4 pubmed
  66. Goracy I, Safranow K, Dawid G, Skonieczna Żydecka K, Kaczmarczyk M, Goracy J, et al. Common genetic variants of the BMP4, BMPR1A, BMPR1B, and ACVR1 genes, left ventricular mass, and other parameters of the heart in newborns. Genet Test Mol Biomarkers. 2012;16:1309-16 pubmed publisher
    ..present study was designed to evaluate the effect of common genetic variants of BMP-4 and its receptors BMPR1A, BMPR1B, and ACVR1 on left ventricular mass (LVM) and other parameters of the heart and blood pressure in newborns...
  67. Voorneveld P, Reimers M, Bastiaannet E, Jacobs R, van Eijk R, Zanders M, et al. Statin Use After Diagnosis of Colon Cancer and Patient Survival. Gastroenterology. 2017;153:470-479.e4 pubmed publisher
    ..Tumor tissues were analyzed by immunohistochemistry for levels of SMAD4, BMPR1A, BMPR1B, and BMPR2 proteins...
  68. Wei C, Wang H, Liu G, Wu M, Cao J, Liu Z, et al. Genome-wide analysis reveals population structure and selection in Chinese indigenous sheep breeds. BMC Genomics. 2015;16:194 pubmed publisher
    ..We also identified known candidate genes such as BMPR1B, MSRB3, and three genes (KIT, MC1R, and FRY) that influence lambing percentage, ear size and coat phenotypes, ..
  69. Bechtold T, Saunders C, Mundy C, Um H, Decker R, Salhab I, et al. Excess BMP Signaling in Heterotopic Cartilage Forming in Prg4-null TMJ Discs. J Dent Res. 2016;95:292-301 pubmed publisher
    ..and chondrocytes, as indicated by phosphorylated Smad 1/5/8 nuclear staining and by elevated expression of Bmp2, Bmpr1b, Bmpr2, and BMP signaling target genes...
  70. Basal E, Ayeni T, Zhang Q, Langstraat C, Donahoe P, Pepin D, et al. Patterns of Müllerian Inhibiting Substance Type II and Candidate Type I Receptors in Epithelial Ovarian Cancer. Curr Mol Med. 2016;16:222-31 pubmed
    ..8%). No differences in overall survival (OS) were noted between combinations. The ALK6 receptor was least often expressed T1R and was associated with lower OS in early stage disease only (p =0.03)...
  71. Lee J, Son M, Woolard K, Donin N, Li A, Cheng C, et al. Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell. 2008;13:69-80 pubmed publisher
    ..astroglial differentiation is impaired due to EZH2-dependent epigenetic silencing of BMP receptor 1B (BMPR1B) in a subset of glioblastoma TICs...
  72. Chida A, Shintani M, Nakayama T, Furutani Y, Hayama E, Inai K, et al. Missense mutations of the BMPR1B (ALK6) gene in childhood idiopathic pulmonary arterial hypertension. Circ J. 2012;76:1501-8 pubmed
    ..SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, bone morphogenetic protein receptor type 1A (BMPR1A) and bone morphogenetic protein receptor type 1B (BMPR1B) genes in 43 IPAH patients who had no mutations in BMPR2, ALK1 and SMAD8...
  73. Lewis R, Keller J, Wan L, Stone J. Bone morphogenetic protein 4 antagonizes hair cell regeneration in the avian auditory epithelium. Hear Res. 2018;364:1-11 pubmed publisher
    ..Supporting cells transcribe genes encoding receptors for BMP4 (BMPR1A, BMPR1B, and BMPR2) and effectors of BMP4 signaling (ID transcription factors)...
  74. Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, et al. Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. J Biol Chem. 2009;284:30097-104 pubmed publisher
    ..These findings provide a novel insight to understand the molecular mechanism underlying the inhibitory effect of BAMBI on TGF-beta signaling. ..
  75. Wang H, Xie Z, Hou T, Li Z, Huang K, Gong J, et al. MiR-125b Regulates the Osteogenic Differentiation of Human Mesenchymal Stem Cells by Targeting BMPR1b. Cell Physiol Biochem. 2017;41:530-542 pubmed publisher
    ..using miRNA target prediction algorithms indicated that the bone morphogenetic protein type Ib receptor (BMPR1b) is a potential target of miR-125b...
  76. Chang H, Cheng J, Fang L, Qiu X, Klausen C, Taylor E, et al. Recombinant BMP4 and BMP7 downregulate pentraxin 3 in human granulosa cells. J Clin Endocrinol Metab. 2015;100:E365-74 pubmed publisher
    ..and small interfering RNAs targeting activin receptor-like kinase (ALK)2, ALK3, and/or ALK6. Small interfering RNAs targeting Smad4 were used to verify the involvement of Smad signaling...
  77. Prates J, Franco Salla G, Dinarte Dos Santos A, da Silva W, da Cunha B, Tajara E, et al. ANXA1Ac₂₋₂₆ peptide reduces ID1 expression in cervical carcinoma cultures. Gene. 2015;570:248-54 pubmed publisher
    ..Four more genes (BMP4, BMPR1B, SMAD1 and SMAD4) of the ID1 pathway were investigated and only one (BMPR1B) shows the same down regulation...
  78. Zhang H, Klausen C, Zhu H, Chang H, Leung P. BMP4 and BMP7 Suppress StAR and Progesterone Production via ALK3 and SMAD1/5/8-SMAD4 in Human Granulosa-Lutein Cells. Endocrinology. 2015;156:4269-80 pubmed publisher
    ..Moreover, small interfering RNA-mediated depletion of ALK3, but not ALK2 or ALK6, reversed the effects of BMP4 and BMP7 on StAR expression...
  79. Ahlawat S, Sharma R, Roy M, Mandakmale S, Prakash V, Tantia M. Genotyping of Novel SNPs in BMPR1B, BMP15, and GDF9 Genes for Association with Prolificacy in Seven Indian Goat Breeds. Anim Biotechnol. 2016;27:199-207 pubmed publisher
    ..In the present study, six novel SNPs in three candidate genes for prolificacy (BMPR1B, BMP15, and GDF9) were genotyped in seven breeds of Indian goats to evaluate their association with litter size...
  80. Rigueur D, Brugger S, Anbarchian T, Kim J, Lee Y, Lyons K. The type I BMP receptor ACVR1/ALK2 is required for chondrogenesis during development. J Bone Miner Res. 2015;30:733-41 pubmed publisher
    ..BMPs transduce their signals through three type I receptors: BMPR1A, BMPR1B, and ACVR1/ALK2...
  81. Latteyer S, Tiedje V, König K, Ting S, Heukamp L, Meder L, et al. Targeted next-generation sequencing for TP53, RAS, BRAF, ALK and NF1 mutations in anaplastic thyroid cancer. Endocrine. 2016;54:733-741 pubmed publisher
  82. Aoki H, Fujii M, Imamura T, Yagi K, Takehara K, Kato M, et al. Synergistic effects of different bone morphogenetic protein type I receptors on alkaline phosphatase induction. J Cell Sci. 2001;114:1483-9 pubmed
    ..Thus, ALK-2 and ALK-3 (or ALK-6) might synergistically induce osteoblast differentiation of C2C12 cells, possibly through efficient activation of downstream signaling pathways. ..
  83. Cao H, Lei S, Deng H, Wang Y. Identification of genes for complex diseases using integrated analysis of multiple types of genomic data. PLoS ONE. 2012;7:e42755 pubmed publisher
    ..g., 'THSD4', 'CRHR1', 'HSD11B1', 'THSD7A', 'BMPR1B' 'ADCY10', 'PRL', 'CA8','ESRRA', 'CALM1', 'CALM1', 'SPARC', and 'LRP1')...
  84. Penney K, Sinnott J, Tyekucheva S, Gerke T, Shui I, Kraft P, et al. Association of prostate cancer risk variants with gene expression in normal and tumor tissue. Cancer Epidemiol Biomarkers Prev. 2015;24:255-60 pubmed publisher
    ..05) associations of variants with the expression of nearby genes including C2orf43, ITGA6, MLPH, CHMP2B, BMPR1B, and MTL5...
  85. Silva L, Kim S, Luczyszyn S, Papalexiou V, Giovanini A, Almeida L, et al. Histological and immunohistochemical evaluation of biphasic calcium phosphate and a mineral trioxide aggregate for bone healing in rat calvaria. Int J Oral Maxillofac Surg. 2015;44:535-42 pubmed publisher osteoid tissue and new bone tissue, as well as the percentage of labelled cells using anti-bone morphogenetic protein receptor type 1B (anti-BMPR1B) antibodies...
  86. Chapellier M, Bachelard Cascales E, Schmidt X, Clément F, Treilleux I, Delay E, et al. Disequilibrium of BMP2 levels in the breast stem cell niche launches epithelial transformation by overamplifying BMPR1B cell response. Stem Cell Reports. 2015;4:239-54 pubmed publisher
    ..cells to high BMP2 levels initiated transformation toward a luminal tumor-like phenotype, mediated by the receptor BMPR1B. Under physiological conditions, BMP2 controlled the maintenance and differentiation of early luminal progenitors, ..
  87. Tao C, Huang S, Wang Y, Wei G, Zhang Y, Qi D, et al. Changes in white and brown adipose tissue microRNA expression in cold-induced mice. Biochem Biophys Res Commun. 2015;463:193-9 pubmed publisher
    ..The expression pattern of miR-144-3p/Bmpr1b/Phlda1 and miR-146a-5p/Sphk2 were further measured by qPCR...
  88. Bosukonda A, Carlson W. Harnessing the BMP signaling pathway to control the formation of cancer stem cells by effects on epithelial-to-mesenchymal transition. Biochem Soc Trans. 2017;45:223-228 pubmed publisher
    ..cells by interacting with type I receptors selectively [activin receptor-like kinase 2 (ALK2) and ALK3, but not ALK6] and type II BMP receptors, activating SMAD 1/5/8 signaling and controlling the cell cycle pathway...
  89. Nishiyama Y, Hasegawa T, Fujita S, Iwata N, Nagao S, Hosoya T, et al. Incretins modulate progesterone biosynthesis by regulating bone morphogenetic protein activity in rat granulosa cells. J Steroid Biochem Mol Biol. 2018;178:82-88 pubmed publisher
    ..The modulatory effects of incretins on endogenous BMP activity may be applicable to treatment of dysregulated steroidogenesis such as polycystic ovary syndrome. ..
  90. Wu Y, Chang H, Huang H, Sheng J, Leung P. Bone morphogenetic protein 2 regulates cell-cell communication by down-regulating connexin43 expression in luteinized human granulosa cells. Mol Hum Reprod. 2017;23:155-165 pubmed publisher
    ..I receptor inhibitors (Dorsomorphin, DMH-1 and SB431542) and target depletion small interfering RNAs (ALK2, ALK3, ALK6 and SMAD4) were used to investigate the underlying molecular mechanisms...
  91. Ribeiro A, Freitas C, Matos L, Gouveia A, Gomes F, Silva Carvalho J, et al. Age-related expression of TGF beta family receptors in human cumulus oophorus cells. J Assist Reprod Genet. 2017;34:1121-1129 pubmed publisher
    ..The expression patterns of OSF receptors BMPR2, ALK 4, ALK5, and activin receptor-like kinase (ALK6) were studied. Independently of age, receptors were found mostly in the cell periphery...
  92. Jung J, Kwon M, Bae S, Yim S, Lee D. Petri net-based prediction of therapeutic targets that recover abnormally phosphorylated proteins in muscle atrophy. BMC Syst Biol. 2018;12:26 pubmed publisher
    ..The three potential targets, i.e. BMPR1B, ROCK, and LEPR, were manually validated with the literature...