Gene Symbol: BMP10
Description: bone morphogenetic protein 10
Alias: bone morphogenetic protein 10
Species: human
Products:     BMP10

Top Publications

  1. Ouarné M, Bouvard C, Boneva G, Mallet C, Ribeiro J, Desroches Castan A, et al. BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer. J Exp Clin Cancer Res. 2018;37:209 pubmed publisher
    ..ALK1 binds with strong affinity to two ligands that belong to the TGF-ß family, BMP9 and BMP10. In the present work, we addressed their specific roles in tumor angiogenesis, cancer development and metastasis ..
  2. Abou Hassan O, Haidar W, Nemer G, Skouri H, Haddad F, Bouakl I. Clinical and genetic characteristics of pulmonary arterial hypertension in Lebanon. BMC Med Genet. 2018;19:89 pubmed publisher
    ..involved previously associated genes T-box transcription factor 4 (TBX4), Bone Morphogenic Protein 10 (BMP10) and Growth Differentiation Factor 2 (GDF2)...
  3. Laux D, Young S, Donovan J, Mansfield C, Upton P, Roman B. Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescence. Development. 2013;140:3403-12 pubmed publisher
    ..To this end, we define cardiac-derived Bmp10 as the crucial ligand for endothelial Alk1 in embryonic vascular development, and provide evidence that ..
  4. Cho E, Mysliwiec M, Carlson C, ANSARI A, Schwartz R, Lee Y. Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development. J Biol Chem. 2018;293:11659-11673 pubmed publisher
    ..mice exhibited elevated expression of neural genes, cardiac jelly, and other key factors including Isl1 and Bmp10 in the developing heart...
  5. Tillet E, Ouarné M, Desroches Castan A, Mallet C, Subileau M, Didier R, et al. A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma. J Biol Chem. 2018;293:10963-10974 pubmed publisher
    Bone morphogenetic protein 9 (BMP9) and BMP10 are the two high-affinity ligands for the endothelial receptor activin receptor-like kinase 1 (ALK1) and are key regulators of vascular remodeling...
  6. Dykes I, van Bueren K, Ashmore R, Floss T, Wurst W, Szumska D, et al. HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Circ Res. 2014;115:23-31 pubmed publisher
    ..5+ and Mesp1+ cardiovascular progenitor lineages. Microarray analysis revealed increased expression of Bmp10. Our results demonstrate a novel role for Hic2 in cardiac development...
  7. Araki M, Hisamitsu T, Kinugasa Katayama Y, Tanaka T, Harada Y, Nakao S, et al. Serum/glucocorticoid-regulated kinase 1 as a novel transcriptional target of bone morphogenetic protein-ALK1 receptor signaling in vascular endothelial cells. Angiogenesis. 2018;21:415-423 pubmed publisher
    Bone morphogenetic protein 9 (BMP9)/BMP10-ALK1 receptor signaling is essential for endothelial differentiation and vascular morphogenesis...
  8. Wang W, Niu Z, Wang Y, Li Y, Zou H, Yang L, et al. Comparative transcriptome analysis of atrial septal defect identifies dysregulated genes during heart septum morphogenesis. Gene. 2016;575:303-12 pubmed publisher
    ..that cardiac specific transcriptional factors (GATA4 and NKX2-5), extracellular signal molecules (VEGFA and BMP10) and cardiac sarcomeric proteins (MYL2, MYL3, MYH7, TNNT1 and TNNT3) were downregulated in ASD which may affect ..
  9. Levet S, Ouarné M, Ciais D, Coutton C, Subileau M, Mallet C, et al. BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus. Proc Natl Acad Sci U S A. 2015;112:E3207-15 pubmed publisher
    ..Two members of the TGFβ family, bone morphogenetic protein 9 (BMP9) and BMP10, have been recently involved in postnatal angiogenesis, both being necessary for remodeling of newly formed ..

More Information


  1. Ruiz S, Zhao H, Chandakkar P, Chatterjee P, Papoin J, Blanc L, et al. A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10. Sci Rep. 2016;5:37366 pubmed publisher
    ..Transmammary-delivered BMP9/10 immunoblocking in the mouse neonatal retina is therefore a practical, noninvasive, reliable, and robust model of HHT vascular pathology. ..
  2. Wang M, Huo Y, Li Y, Otecko N, Su L, Xu H, et al. Comparative population genomics reveals genetic basis underlying body size of domestic chickens. J Mol Cell Biol. 2016;8:542-552 pubmed
    ..The most significant signal was mapped to the BMP10 gene, whose expression was upregulated in the Yuanbao chicken...
  3. Kahr P, Piccini I, Fabritz L, Greber B, Schöler H, Scheld H, et al. Systematic analysis of gene expression differences between left and right atria in different mouse strains and in human atrial tissue. PLoS ONE. 2011;6:e26389 pubmed publisher
    ..Independent of strain and age, Pitx2c was the gene with the highest enrichment in left atrium, while Bmp10, a member of the TGFβ family, showed highest enrichment in right atrium...
  4. Castonguay R, Werner E, Matthews R, Presman E, Mulivor A, Solban N, et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011;286:30034-46 pubmed publisher
    ..ECD-Fc bound directly, specifically, and with high affinity to bone morphogenetic proteins 9 and 10 (BMP9 and BMP10) in surface plasmon resonance (Biacore) and cell-based assays...
  5. Ye L, Bokobza S, Li J, Moazzam M, Chen J, Mansel R, et al. Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer. Cancer Sci. 2010;101:2137-44 pubmed publisher
    ..Bone morphogenetic protein-10 (BMP-10) may function as a tumor suppressor in breast cancer. ..
  6. Susan Resiga D, Essalmani R, Hamelin J, Asselin M, Benjannet S, Chamberland A, et al. Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10. J Biol Chem. 2011;286:22785-94 pubmed publisher
    b>Bone morphogenetic protein 10 (BMP10) is a member of the TGF-β superfamily and plays a critical role in heart development. In the postnatal heart, BMP10 is restricted to the right atrium...
  7. Wang R, Su C, Wang X, Fu Q, Gao X, Zhang C, et al. Global gene expression analysis combined with a genomics approach for the identification of signal transduction networks involved in postnatal mouse myocardial proliferation and development. Int J Mol Med. 2018;41:311-321 pubmed publisher
    ..Notably, the cluster analysis revealed that bone morphogenetic protein (BMP)1, BMP10, cyclin E2, E2F transcription factor 1 and insulin like growth factor 1 exhibited increased expression in ..
  8. Wu M, Chen W, Mi J, Chen D, Wang W, Gao H. Expression analysis of BMP2, BMP5, BMP10 in human colon tissues from Hirschsprung disease patients. Int J Clin Exp Pathol. 2014;7:529-36 pubmed
    ..BMP2, BMP5 and BMP10 exert their biological functions by interacting with membrane bound receptors belonging to the serine/threonine ..
  9. Neuhaus H, Rosen V, Thies R. Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily. Mech Dev. 1999;80:181-4 pubmed
    ..After 12.5 d.p.c., additional BMP-10 expression is seen in the atrial wall. The data presented here suggest that BMP-10 plays an important role in trabeculation of the embryonic heart. ..
  10. Li W, Salmon R, Jiang H, Morrell N. Regulation of the ALK1 ligands, BMP9 and BMP10. Biochem Soc Trans. 2016;44:1135-41 pubmed publisher
    Bone morphogenetic protein (BMP)9 and BMP10 are high affinity ligands for activin receptor-like kinase 1 (ALK1), a type I BMP receptor mainly expressed on vascular endothelial cells (ECs)...
  11. Jumabay M, Zhumabai J, Mansurov N, Niklason K, Guihard P, Cubberly M, et al. Combined effects of bone morphogenetic protein 10 and crossveinless-2 on cardiomyocyte differentiation in mouse adipocyte-derived stem cells. J Cell Physiol. 2018;233:1812-1822 pubmed publisher
    ..The objective of this study was to examine the combined effects of BMP10 and CV2 on cardiomyocyte differentiation using mouse dedifferentiated fat (mDFAT) cells, which spontaneously ..
  12. Nakano N, Hori H, Abe M, Shibata H, Arimura T, Sasaoka T, et al. Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2007;293:H3396-403 pubmed
    ..In this study, we investigated the involvement of bone morphogenetic protein-10 (BMP10) in hypertension-induced cardiac hypertrophy...
  13. David L, Mallet C, Mazerbourg S, Feige J, Bailly S. Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood. 2007;109:1953-61 pubmed
    ..b>BMP10, which is structurally close to BMP9, is also a potent ALK1 ligand...
  14. Lei H, Wang J, Lu P, Si X, Han K, Ruan T, et al. BMP10 inhibited the growth and migration of gastric cancer cells. Tumour Biol. 2016;37:3025-31 pubmed publisher
    b>Bone morphogenetic protein 10 (BMP10), a novel member of BMP family, has been identified as an important regulator for angiogenesis. Dysregulation of BMP has been observed in several cancer types...
  15. Jiang H, Salmon R, Upton P, Wei Z, Lawera A, Davenport A, et al. The Prodomain-bound Form of Bone Morphogenetic Protein 10 Is Biologically Active on Endothelial Cells. J Biol Chem. 2016;291:2954-66 pubmed publisher
    b>BMP10 is highly expressed in the developing heart and plays essential roles in cardiogenesis. BMP10 deletion in mice results in embryonic lethality because of impaired cardiac development...
  16. Mitrofan C, Appleby S, Nash G, Mallat Z, Chilvers E, Upton P, et al. Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2. J Biol Chem. 2017;292:13714-13726 pubmed publisher
    Bone morphogenetic proteins 9 and 10 (BMP9/BMP10) are circulating cytokines with important roles in endothelial homeostasis...
  17. Townson S, Martinez Hackert E, Greppi C, Lowden P, Sako D, Liu J, et al. Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex. J Biol Chem. 2012;287:27313-25 pubmed publisher
    ..The TGF-? family ligands BMP9 and BMP10 as well as the three type II TGF-? family receptors ActRIIA, ActRIIB, and BMPRII have been implicated in ALK1 ..
  18. Niessen K, Zhang G, Ridgway J, Chen H, Yan M. ALK1 signaling regulates early postnatal lymphatic vessel development. Blood. 2010;115:1654-61 pubmed publisher
    ..Thus, our study reveals a novel aspect of ALK1 signaling in regulating lymphatic development and suggests that targeting ALK1 pathway might provide additional control of lymphangiogenesis in human diseases. ..
  19. Sengle G, Charbonneau N, Ono R, Sasaki T, Alvarez J, Keene D, et al. Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J Biol Chem. 2008;283:13874-88 pubmed publisher
    ..These data implicate the fibrillin microfibril network in the extracellular control of BMP signaling and demonstrate differences in how prodomains target their growth factors to the extracellular space. ..
  20. Mazerbourg S, Sangkuhl K, Luo C, Sudo S, Klein C, Hsueh A. Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses. J Biol Chem. 2005;280:32122-32 pubmed
    ..We characterized the dimeric nature of recombinant GDF6 (also known as BMP13), GDF7 (also known as BMP12), and BMP10. We demonstrated their bioactivities based on the activation of Smad1/5/8-, but not Smad2/3-, responsive promoter ..
  21. Zhang N, Ye L, Wu L, Deng X, Yang Y, Jiang W. Expression of bone morphogenetic protein-10 (BMP10) in human urothelial cancer of the bladder and its effects on the aggressiveness of bladder cancer cells in vitro. Anticancer Res. 2013;33:1917-25 pubmed
    Bone morphogenetic protein-10 (BMP10), a novel member of the bone morphogenetic protein (BMP) family, has been indicated as a possible tumour suppressor in prostate and breast cancer...