Gene Symbol: BMCP1
Description: solute carrier family 25 member 14
Alias: BMCP1, UCP5, brain mitochondrial carrier protein 1, mitochondrial uncoupling protein 5
Species: human
Products:     BMCP1

Top Publications

  1. Ricquier D, Bouillaud F. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem J. 2000;345 Pt 2:161-79 pubmed
    ..Other aims will be to investigate the possible roles of UCP2 and UCP3 in response to oxidative stress, lipid peroxidation, inflammatory processes, fever and regulation of temperature in certain specific parts of the body. ..
  2. Santandreu F, Valle A, Fernandez De Mattos S, Roca P, Oliver J. Hydrogen peroxide regulates the mitochondrial content of uncoupling protein 5 in colon cancer cells. Cell Physiol Biochem. 2009;24:379-90 pubmed publisher
    Uncoupling protein-2 (UCP2) and uncoupling protein-5 (UCP5) are ion carriers located in the inner mitochondrial membrane that mediate a regulated discharge of the proton gradient generated by the respiratory chain and are possibly ..
  3. Dong C, Della Morte D, Wang L, Cabral D, Beecham A, McClendon M, et al. Association of the sirtuin and mitochondrial uncoupling protein genes with carotid plaque. PLoS ONE. 2011;6:e27157 pubmed publisher
    ..31, 1.18-1.45, Bonferroni-corrected p?=?1.4×10(-5)), whereas T-carriers of the UCP5 SNP rs5977238 had an decreased risk for carotid plaque (OR?=?0.49, 95% CI?=?0.32-0.74, Bonferroni-corrected p?=?0...
  4. Mendez Romero O, Uribe Carvajal S, Chiquete Felix N, Muhlia Almazan A. Mitochondrial uncoupling proteins UCP4 and UCP5 from the Pacific white shrimp Litopenaeus vannamei. J Bioenerg Biomembr. 2019;51:103-119 pubmed publisher
    ..Results confirmed UCPs as the first uncoupling mechanism reported in this species, but their role in the oxidative stress response remains to be confirmed. ..
  5. Andrés Benito P, Dominguez Gonzalez M, Ferrer I. Altered gene transcription linked to astrocytes and oligodendrocytes in frontal cortex in Creutzfeldt-Jakob disease. Prion. 2018;12:216-225 pubmed publisher
    ..member 2, coding for glutamate transporter 1: GLT1), AQ4 (aquaporin 4), MPC1 (mitochondrial pyruvate carrier 1) and UCP5 (mitochondrial uncoupled protein 5) mRNAs were significantly down-regulated in CJD MM1 and CJD VV2, and GJA1 (..
  6. Bai L, Liu B, Ji C, Zhao S, Liu S, Wang R, et al. Hypoxic and Cold Adaptation Insights from the Himalayan Marmot Genome. iScience. 2019;11:519-530 pubmed publisher
    ..These findings shed light on the molecular and genetic basis underlying adaptation to extreme environments in the Himalayan marmot. ..
  7. Zheng G, Lin J, Zheng W, Cao J, Zhao Z. Energy intake, oxidative stress and antioxidant in mice during lactation. Dongwuxue Yanjiu. 2015;36:95-102 pubmed
    ..Ucp4 and ucp5 gene expression of brain was 394% and 577% higher in Lac mice than in Non-Lac mice...
  8. Perreten Lambert H, Zenger M, Azarias G, Chatton J, Magistretti P, Lengacher S. Control of mitochondrial pH by uncoupling protein 4 in astrocytes promotes neuronal survival. J Biol Chem. 2014;289:31014-28 pubmed publisher
    ..The main UCP isoforms expressed in the brain are UCP2, UCP4, and UCP5. We examined in particular the role of UCP4 in neuron-astrocyte metabolic coupling and measured a range of ..
  9. Picklo M, Johnson L, Idso J. PPAR mRNA Levels Are Modified by Dietary n-3 Fatty Acid Restriction and Energy Restriction in the Brain and Liver of Growing Rats. J Nutr. 2017;147:161-169 pubmed publisher
    ..ER reduced Ucp3 mRNA by nearly 50% in the cerebral cortex, cerebellum, and liver, and Ucp5 mRNA was 30% lower in the cerebellum of rats receiving the CO diet...

More Information


  1. Bahl V, Johnson K, Phandthong R, Zahedi A, Schick S, Talbot P. From the Cover: Thirdhand Cigarette Smoke Causes Stress-Induced Mitochondrial Hyperfusion and Alters the Transcriptional Profile of Stem Cells. Toxicol Sci. 2016;153:55-69 pubmed publisher apoptosis-related genes, including Aifm2, Bbc3, and Bid There was also down regulation of Ucp2, Ucp4, and Ucp5, genes that decrease MMP thereby reducing oxidative phosphorylation, while promoting glycolysis...
  2. Smorodchenko A, Schneider S, Rupprecht A, Hilse K, Sasgary S, Zeitz U, et al. UCP2 up-regulation within the course of autoimmune encephalomyelitis correlates with T-lymphocyte activation. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1002-1012 pubmed publisher
    ..Several members of the mitochondrial uncoupling protein subfamily (UCP2-UCP5) were suggested to regulate ROS by diminishing the mitochondrial membrane potential and constitute therefore a ..
  3. Hoang T, Kuljanin M, Smith M, Jelokhani Niaraki M. A biophysical study on molecular physiology of the uncoupling proteins of the central nervous system. Biosci Rep. 2015;35: pubmed publisher
    ..It has been proposed that the three neuronal human UCPs (UCP2, UCP4 and UCP5) in the central nervous system (CNS) play significant roles in reducing cellular oxidative stress...
  4. Jeong H, Song K, Seo M, Caetano Anollés K, Kim J, Kwak W, et al. Exploring evidence of positive selection reveals genetic basis of meat quality traits in Berkshire pigs through whole genome sequencing. BMC Genet. 2015;16:104 pubmed publisher
    ..These results can provide a basis for future research on the genomic characteristics of Berkshire pigs. ..
  5. Erden Y, Tekin S, Sandal S, Onalan E, Tektemur A, Kirbag S. Effects of central irisin administration on the uncoupling proteins in rat brain. Neurosci Lett. 2016;618:6-13 pubmed publisher
    ..pituitary gland, hippocampus, cerebellum, striatum and cortex areas were separated and the UCP2, UCP3, UCP4 and UCP5 mRNA levels were determined. Just before the animals were killed, their body temperatures were recorded...
  6. Montesanto A, Crocco P, Anfossi M, Smirne N, Puccio G, Colao R, et al. The Genetic Variability of UCP4 Affects the Individual Susceptibility to Late-Onset Alzheimer's Disease and Modifies the Disease's Risk in APOE-ɛ4 Carriers. J Alzheimers Dis. 2016;51:1265-74 pubmed publisher
    ..Previous data suggested that neuronal UCPs (UCP2, UCP4, and UCP5) can directly influence synaptic plasticity, neurotransmission, and neurodegenerative processes, and have a crucial ..
  7. Ramsden D, Ho P, Ho J, Liu H, So D, Tse H, et al. Human neuronal uncoupling proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation, and physiological role in protection against oxidative stress and mitochondrial dysfunction. Brain Behav. 2012;2:468-78 pubmed publisher
    ..The protective mechanisms of the two proteins against neurotoxins and their possible role in regulating intracellular calcium movement, particularly with regard to the pathogenesis of Parkinson's disease are discussed. ..
  8. Hoang T, Smith M, Jelokhani Niaraki M. Toward understanding the mechanism of ion transport activity of neuronal uncoupling proteins UCP2, UCP4, and UCP5. Biochemistry. 2012;51:4004-14 pubmed publisher
    Neuronal uncoupling proteins (UCP2, UCP4, and UCP5) have crucial roles in the function and protection of the central nervous system (CNS)...
  9. Yasuno K, Ando S, Misumi S, Makino S, Kulski J, Muratake T, et al. Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:250-3 pubmed
    ..We performed a case-control study using tag SNPs in the mitochondrial uncoupling protein genes, UCP2, UCP4, and BMCP1/UCP5, to investigate their association with schizophrenia...
  10. Ho P, Chu A, Kwok K, Kung M, Ramsden D, Ho S. Knockdown of uncoupling protein-5 in neuronal SH-SY5Y cells: Effects on MPP+-induced mitochondrial membrane depolarization, ATP deficiency, and oxidative cytotoxicity. J Neurosci Res. 2006;84:1358-66 pubmed
    ..The physiological role of neuronal specific UCP5 is unknown...
  11. Kim Han J, Reichert S, Quick K, Dugan L. BMCP1: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production. J Neurochem. 2001;79:658-68 pubmed
    ..However, the function of brain mitochondrial carrier protein 1 (BMCP1), which is highly expressed in brain, remains to be determined...
  12. Sanchis D, Fleury C, Chomiki N, Goubern M, Huang Q, Neverova M, et al. BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast. J Biol Chem. 1998;273:34611-5 pubmed
    ..homologue of the mitochondrial carriers predominantly expressed in the central nervous system and referred to as BMCP1 (brain mitochondrial carrier protein-1)...
  13. Xu Y, Liu Y, Xia C, GAO P, Liu J. Evidence for involvement of uncoupling proteins in cerebral mitochondrial oxidative phosphorylation deficiency of rats exposed to 5,000 m high altitude. Neurochem Res. 2013;38:282-9 pubmed publisher
    ..cerebral UCPs activity significantly increased; Q-PCR and western blot showed upregulated expression of UCP4 and UCP5. Moreover, cerebral NEFA concentration increased...
  14. Anitha A, Nakamura K, Thanseem I, Yamada K, Iwayama Y, Toyota T, et al. Brain region-specific altered expression and association of mitochondria-related genes in autism. Mol Autism. 2012;3:12 pubmed publisher
    ..Our study, though preliminary, brings to light some new genes associated with MtD in autism. If MtD is detected in early stages, treatment strategies aimed at reducing its impact may be adopted. ..
  15. Nakase T, Yoshida Y, Nagata K. Amplified expression of uncoupling proteins in human brain ischemic lesions. Neuropathology. 2007;27:442-7 pubmed
    ..Recently, it has been reported that UCP2 and UCP5 might reduce free radical stress in the ischemic condition in in vitro models, suggesting both as potential ..
  16. Yang X, Pratley R, Tokraks S, Tataranni P, Permana P. UCP5/BMCP1 transcript isoforms in human skeletal muscle: relationship of the short-insert isoform with lipid oxidation and resting metabolic rates. Mol Genet Metab. 2002;75:369-73 pubmed
    Uncoupling protein 5 (UCP5) or brain mitochondrial carrier protein-1 (BMCP1) enhances mitochondrial proton leak in vitro and its hepatic and brain expression profiles are modulated by diet and cold exposure in mice...
  17. Cardoso S, Seiça R, Moreira P. Uncoupling Protein 2 Inhibition Exacerbates Glucose Fluctuation-Mediated Neuronal Effects. Neurotox Res. 2018;33:388-401 pubmed publisher
    ..synaptic integrity, decreased the protein expression levels of NRF1, and increased the protein expression levels of UCP5. Further, in the control and LG conditions, genipin increased mitochondrial ROS and the protein expression levels ..
  18. Yu X, Mao W, Zhong A, Schow P, Brush J, Sherwood S, et al. Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation. FASEB J. 2000;14:1611-8 pubmed
    ..Here we characterized another newly described member of the uncoupling protein family, termed UCP5 (also called BMCP1)...
  19. Jezek P, Urbankova E. Specific sequence of motifs of mitochondrial uncoupling proteins. IUBMB Life. 2000;49:63-70 pubmed
    ..for the exclusivity of common sequence motifs of the mitochondrial uncoupling proteins (UCP1, UCP2, UCP3, UCP4, BMCP1, and plant UCP [PUMP]) within the gene family of mitochondrial anion carrier proteins...