Gene Symbol: BLOC1S5
Description: biogenesis of lysosomal organelles complex 1 subunit 5
Alias: BLOS5, MUTED, biogenesis of lysosome-related organelles complex 1 subunit 5, BLOC-1 subunit 5, biogenesis of lysosomal organelles complex-1, subunit 5, muted, muted homolog, protein Muted homolog
Species: human
Products:     BLOC1S5

Top Publications

  1. Warne J, John C, Christian H, Morris J, Flower R, Sugden D, et al. Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue. Am J Physiol Endocrinol Metab. 2006;291:E1264-73 pubmed
    ..Lipopolysaccharide (LPS) also stimulated lipolysis in vitro, but its effects were muted by ANXA1 gene deletion...
  2. Arrabal Martin M, Cano García M, Arrabal Polo M, Domínguez Amillo A, Canales Casco N, de la Torre Trillo J, et al. [Etiopathogenic factors of the different types of urinary litiasis.]. Arch Esp Urol. 2017;70:40-50 pubmed
    ..rare, it was classically divided in three types and now passed to be classified in type A and B depending on the muted gene, and it is more useful to perform direct 24-hour urine measurement than screening tests which have low ..
  3. Jennings Gee J, Pardee T, Gmeiner W. Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity. Exp Hematol. 2013;41:180-188.e4 pubmed publisher
    ..Top1CC form in cells upon re-entry into S-phase, resulting in DNA double-strand breaks, and initiating apoptotic signaling that can be either muted or enhanced by Jnk-signaling depending on cell type.
  4. Baka J, Csakvari E, Huzian O, Dobos N, Siklos L, Leranth C, et al. Stress induces equivalent remodeling of hippocampal spine synapses in a simulated postpartum environment and in a female rat model of major depression. Neuroscience. 2017;343:384-397 pubmed publisher
    ..This protective effect appears to be mediated by a muted stress response as measured by serum corticosterone concentrations...
  5. Wang L, Li X, Gao Y, Wang S, Zhao L, Dong J, et al. Activation of VEGF/Flk-1-ERK Pathway Induced Blood-Brain Barrier Injury After Microwave Exposure. Mol Neurobiol. 2015;52:478-91 pubmed publisher
    ..The increase in expression of ERK signal transduction molecules was muted, while the expression and the activity of occludin were accelerated, as well as the interactions of occludin with ..
  6. Meyer B, Fabbrizi M, Raj S, Zobel C, Hallahan D, Sharma G. Histone H3 Lysine 9 Acetylation Obstructs ATM Activation and Promotes Ionizing Radiation Sensitivity in Normal Stem Cells. Stem Cell Reports. 2016;7:1013-1022 pubmed publisher
    ..Suv39h1 abrogated the radioprotective effect of MOZ inhibition, suggesting that high H3K9ac promoted by MOZ in ES cells obstructs local upregulation of H3K9me3 and contributes to muted DDR and increased radiosensitivity.
  7. Yamaguchi A, Takanashi K. FUS interacts with nuclear matrix-associated protein SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription. Sci Rep. 2016;6:35195 pubmed publisher
    ..Moreover, FUS interacts with another nuclear matrix-associated protein Matrin3, which is muted in a subset of familial ALS cases and reportedly interacts with TDP-43...
  8. Vakili H, Jin Y, Cattini P. Energy homeostasis targets chromosomal reconfiguration of the human GH1 locus. J Clin Invest. 2014;124:5002-12 pubmed publisher
    ..Incorporation of physical activity muted the effects of excess caloric intake on insulin levels, GH1 promoter hyperacetylation, chromosomal architecture, ..
  9. Hargan K, Michelutti N, Coleman K, Grooms C, Blais J, Kimpe L, et al. Cliff-nesting seabirds influence production and sediment chemistry of lakes situated above their colony. Sci Total Environ. 2017;576:85-98 pubmed publisher
    ..colony suggest climate warming since ~1950 was the most likely driver of limnological changes, but this effect was muted in the more distant lakes...

More Information

Publications107 found, 100 shown here

  1. Khor C, Vannberg F, Chapman S, Guo H, Wong S, Walley A, et al. CISH and susceptibility to infectious diseases. N Engl J Med. 2010;362:2092-101 pubmed publisher
    ..cells obtained from adult subjects carrying the -292 variant, as compared with wild-type cells, showed a muted response to the stimulation of interleukin-2 production--that is, 25 to 40% less CISH expression...
  2. Fluegge K. Humoral immunity and autism spectrum disorders. Immunol Lett. 2017;185:90-92 pubmed publisher
    ..targets, in particular, may promote the oft-noted humoral immunophenotypes in ASD, including B cell survival and muted antibody responses, this correspondence supports an existing line of evidence that air pollution, and particularly ..
  3. Jiao C, Gao F, Ou L, Yu J, Li M, Wei P, et al. Tetrahydroxy stilbene glycoside (TSG) antagonizes A?-induced hippocampal neuron injury by suppressing mitochondrial dysfunction via Nrf2-dependent HO-1 pathway. Biomed Pharmacother. 2017;96:222-228 pubmed publisher
    ..Importantly, blocking this pathway by si-Nrf2 transfection or HO-1 antagonist ZnPP notably muted the cytoprotective effects of TSG on neuronal cell cytotoxic injury upon A? stimulation...
  4. Paloschi V, Gådin J, Khan S, Björck H, Du L, Maleki S, et al. Aneurysm development in patients with a bicuspid aortic valve is not associated with transforming growth factor-β activation. Arterioscler Thromb Vasc Biol. 2015;35:973-80 pubmed publisher
    ..Our findings suggest that TGFβ activation during aneurysm formation is muted in patients with BAV, possibly as a result of an increased TGFβ sequestration in the extracellular space.
  5. Watkins A, Wood C, Lin M, Abbott B. The effects of perfluorinated chemicals on adipocyte differentiation in vitro. Mol Cell Endocrinol. 2015;400:90-101 pubmed publisher
    ..By comparison, the effects on gene expression were muted for the carboxylated PFAAs and for the PPARα agonist WY-14,643...
  6. Di C, Lin X, Zhang Y, Zhong W, Yuan Y, Zhou T, et al. Basophil-associated OX40 ligand participates in the initiation of Th2 responses during airway inflammation. J Biol Chem. 2015;290:12523-36 pubmed publisher
    ..of OVA-immunized mice triggered a robust Th2 response and eosinophilic inflammation in wild-type mice but largely muted in OX40(-/-) mice and mice receiving OX40L-blocked basophils...
  7. Ghaemi B, Shaabani E, Najafi Taher R, Jafari Nodooshan S, Sadeghpour A, Kharrazi S, et al. Intracellular ROS Induction by Ag@ZnO Core-Shell Nanoparticles: Frontiers of Permanent Optically Active Holes in Breast Cancer Theranostic. ACS Appl Mater Interfaces. 2018;10:24370-24381 pubmed publisher
    ..Also, preincubation of breast cancer cells with Ag@ZnO NPs in dark conditions muted NP-related toxic effects and consequent apoptotic fate, highlighting biocompatible properties of unexcited Ag@ZnO ..
  8. Barrientos T, Laothamatas I, Koves T, Soderblom E, Bryan M, Moseley M, et al. Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle. EBioMedicine. 2015;2:1705-17 pubmed publisher
    ..Inactivation of Tfr1 incapacitated normal energy production in muscle, leading to growth arrest and a muted attempt to switch to fatty acid β oxidation, using up fat stores...
  9. Morey J, Neely M, Lunardi D, Anderson P, Schwacke L, Campbell M, et al. RNA-Seq analysis of seasonal and individual variation in blood transcriptomes of healthy managed bottlenose dolphins. BMC Genomics. 2016;17:720 pubmed publisher
    ..Correlations with hematological parameters, distinct from muted seasonal effects, suggest that the otherwise relatively stable blood transcriptome may be a useful indicator of ..
  10. Peragine D, Yousuf Y, Fu Y, Swift Gallant A, Ginzberg K, Holmes M. Contrasting effects of opposite- versus same-sex housing on hormones, behavior and neurogenesis in a eusocial mammal. Horm Behav. 2016;81:28-37 pubmed publisher
    ..and enhances hippocampal plasticity, while SS pairing is stressful, resulting in enhanced HPA activation and muted hippocampal neurogenesis relative to OS pairs...
  11. Myles I, Fontecilla N, Janelsins B, Vithayathil P, Segre J, Datta S. Parental dietary fat intake alters offspring microbiome and immunity. J Immunol. 2013;191:3200-9 pubmed publisher
    ..They had heightened colonic inflammatory responses, with increased circulating bacterial LPS and muted systemic LPS responsiveness...
  12. Moosavi M, Sharifi M, Ghafary S, Mohammadalipour Z, Khataee A, Rahmati M, et al. Photodynamic N-TiO2 Nanoparticle Treatment Induces Controlled ROS-mediated Autophagy and Terminal Differentiation of Leukemia Cells. Sci Rep. 2016;6:34413 pubmed publisher
    ..Pre-incubation of leukemic cells with ROS scavengers muted the effect of N-TiO2 NP-based PDT on cell fate, highlighting the upstream role of ROS in our system...
  13. Keniry A, Gearing L, Jansz N, Liu J, Holik A, Hickey P, et al. Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing. Epigenetics Chromatin. 2016;9:16 pubmed publisher
    ..The role of this mark is most apparent during the establishment phase of gene silencing, with a more muted effect on maintenance of the silent state...
  14. Marino A, Morabito R, La Spada G, Adragna N, Lauf P. Mechanisms of hyposmotic volume regulation in isolated nematocytes of the anthozoan Aiptasia diaphana. Cell Physiol Biochem. 2010;26:209-18 pubmed publisher
    ..Ba (3 mM) inhibited RVD. NEM and OA, applied separately, inhibited the osmotic phase and muted RVD suggesting primary action on water transport (aquaporins)...
  15. Zhang K, Rajput S, Lee K, Wang D, Huang J, Folger J, et al. Evidence supporting a role for SMAD2/3 in bovine early embryonic development: potential implications for embryotropic actions of follistatin. Biol Reprod. 2015;93:86 pubmed publisher
    ..and stimulatory actions of follistatin on 8- to 16-cell and that blastocyst rates, but not early cleavage, are muted when SMAD2/3 signaling is inhibited...
  16. Hartman P, Barry J, Finstad W, Khan N, Tanaka M, Yasuda K, et al. Ethyl methanesulfonate induces mutations in Caenorhabditis elegans embryos at a high frequency. Mutat Res. 2014;766-767:44-8 pubmed publisher
    ..5-fold higher than when CB665 adults were similarly mutagenized, which was predicted given that cell-cycle checkpoints are muted in C. elegans embryos. The mutation spectrum was similar to that obtained after standard EMS mutagenesis.
  17. Mac Nair C, Schlamp C, Montgomery A, Shestopalov V, Nickells R. Retinal glial responses to optic nerve crush are attenuated in Bax-deficient mice and modulated by purinergic signaling pathways. J Neuroinflammation. 2016;13:93 pubmed publisher
    ..ONC induced activation of both macroglia and microglia in the retina, and both these responses were dramatically muted if RGC death was blocked by deletion of the Bax gene...
  18. Cheng X, Xia Y, Serti E, Block P, Chung M, Chayama K, et al. Hepatitis B virus evades innate immunity of hepatocytes but activates cytokine production by macrophages. Hepatology. 2017;66:1779-1793 pubmed publisher
    ..We showed that the DNA innate sensing pathways are poorly active in hepatocytes, consistent with muted innate immune recognition of HBV...
  19. Kono N, Amin Wetzel N, Ron D. Generic membrane-spanning features endow IRE1? with responsiveness to membrane aberrancy. Mol Biol Cell. 2017;28:2318-2332 pubmed publisher
    ..Our data suggest that IRE1?'s conserved TMD may have been selected for features imparting a relatively muted response to acyl-chain saturation.
  20. Caprariello A, Rogers J, Morgan M, Hoghooghi V, Plemel J, Koebel A, et al. Biochemically altered myelin triggers autoimmune demyelination. Proc Natl Acad Sci U S A. 2018;115:5528-5533 pubmed publisher
    ..Moreover, cultured splenocytes were reactive against donor myelin isolates, a response that was substantially muted when splenocytes were exposed to myelin from donors treated with PAD inhibitors...
  21. Han M, Hu Z, Chen C, Chen Y, Gucek M, Li Z, et al. Dysbindin-associated proteome in the p2 synaptosome fraction of mouse brain. J Proteome Res. 2014;13:4567-80 pubmed publisher
    ..The interactions of several selected candidates, including WDR11, FAM91A1, snapin, muted, pallidin, and two proteasome subunits, PSMD9 and PSMA4, were verified by coimmunoprecipitation...
  22. Horodynski M, Brophy Herb H, Martoccio T, Contreras D, Peterson K, Shattuck M, et al. Familial psychosocial risk classes and preschooler body mass index: The moderating effect of caregiver feeding style. Appetite. 2018;123:216-224 pubmed publisher
    ..Uninvolved feeding styles intensified the risk and an authoritative feeding style muted the risk conferred by living in a poor, food-insecure, and depressed family...
  23. Muller A, Freed D. Basic and Clinical Observations of Mevalonate Depletion on the Mevalonate Signaling Pathway. Curr Mol Pharmacol. 2017;10:6-12 pubmed publisher
    ..It is evident that mevalonate production is a pivotal component of normal homeostatic cell processing, especially in maintaining a muted inflammatory response.
  24. Clark J, Kim K, Basom R, Gharib S. Plasticity of airway epithelial cell transcriptome in response to flagellin. PLoS ONE. 2015;10:e0115486 pubmed publisher
    ..In contrast, AECs in ALI culture had an unexpectedly muted response to flagellin, both in number of genes expressed and relative enrichment of inflammatory and immune ..
  25. Allen E, Muhwezi W, Henriksson D, Mbonye A. Health facility management and access: a qualitative analysis of challenges to seeking healthcare for children under five in Uganda. Health Policy Plan. 2017;32:934-942 pubmed publisher
    ..national planners and donors-it should be done while recognizing that alleviating such barriers may have a more muted effect on caretakers who are geographically harder to reach - and by extension, those whose children have an ..
  26. Macari S, DiNicola L, Kane Grade F, Prince E, Vernetti A, Powell K, et al. Emotional Expressivity in Toddlers With Autism Spectrum Disorder. J Am Acad Child Adolesc Psychiatry. 2018;57:828-836.e2 pubmed publisher
    ..The study provides no support for a negative emotionality bias in ASD. Instead, toddlers with ASD display a muted response to threat and an accentuated response to goal blockage, whereas the ability to express positive emotions ..
  27. Smith K, Oxley D, Hibbing M, Alford J, Hibbing J. Disgust sensitivity and the neurophysiology of left-right political orientations. PLoS ONE. 2011;6:e25552 pubmed publisher
    ..likely to self-identify as conservative and, especially, to oppose gay marriage than are individuals with more muted physiological responses to the same images...
  28. Johnson J, Paul M, Kniffin C, Anderson P, Burnett L, Burnett K. High CO2 alters the hypoxia response of the Pacific whiteleg shrimp (Litopenaeus vannamei) transcriptome including known and novel hemocyanin isoforms. Physiol Genomics. 2015;47:548-58 pubmed publisher
    ..The addition of CO2 to hypoxia muted the transcriptomic response of all the Hc subunits to low O2, except for the β-type subunit.
  29. Menon M, Dalela D, Jamil M, Diaz M, Tallman C, Abdollah F, et al. Functional Recovery, Oncologic Outcomes and Postoperative Complications after Robot-Assisted Radical Prostatectomy: An Evidence-Based Analysis Comparing the Retzius Sparing and Standard Approaches. J Urol. 2018;199:1210-1217 pubmed publisher
    ..approach robot-assisted radical prostatectomy the differences in urinary continence seen at 3 months were muted at the 12-month followup...
  30. McQuarrie M. The revolt of the Rust Belt: place and politics in the age of anger. Br J Sociol. 2017;68 Suppl 1:S120-S152 pubmed publisher
    ..the Democratic Party and the federal government meant that the political implications of regional decline would be muted. However, as these institutions frayed, Rust Belt voters were made available to candidates that challenged the ..
  31. Ericsson A, Gagliardi J, Bouhan D, Spollen W, Givan S, Franklin C. The influence of caging, bedding, and diet on the composition of the microbiota in different regions of the mouse gut. Sci Rep. 2018;8:4065 pubmed publisher
    ..of the microbiota present in certain regions of the gut, most notably the cecum, and that those changes are muted during colonic transit...
  32. HANNA E, Penman J, Jónsson T, Bigg G, Björnsson H, Sjúrðarson S, et al. Meteorological effects of the solar eclipse of 20 March 2015: analysis of UK Met Office automatic weather station data and comparison with automatic weather station data from the Faroes and Iceland. Philos Trans A Math Phys Eng Sci. 2016;374: pubmed publisher
    ..generally clearer, but here too there was no evidence of an eclipse cyclone; in the Faroes, there was a much more muted meteorological signature...
  33. Veldhuis J, Straume M, Iranmanesh A, Mulligan T, Jaffe C, Barkan A, et al. Secretory process regularity monitors neuroendocrine feedback and feedforward signaling strength in humans. Am J Physiol Regul Integr Comp Physiol. 2001;280:R721-9 pubmed
    ..In particular, approximate entropy quantified degradation of secretory subpattern orderliness under either muted feedback restraint or heightened feedforward drive...
  34. Dalu T, Wasserman R, Tonkin J, Mwedzi T, Magoro M, Weyl O. Water or sediment? Partitioning the role of water column and sediment chemistry as drivers of macroinvertebrate communities in an austral South African stream. Sci Total Environ. 2017;607-608:317-325 pubmed publisher
    ..reflects the relative lack of major variability in water chemistry compared to sediment chemistry between seasons and the relatively muted variability in precipitation between seasons than the more classic Austral temperate climates.
  35. Gleichsner A, Reinhart K, Minchella D. Of mice and worms: are co-infections with unrelated parasite strains more damaging to definitive hosts?. Int J Parasitol. 2018;48:881-885 pubmed publisher
    ..Damage to the host by the dominant strain was muted by the presence of a competitor in the intermediate host, but was largely unaffected in the definitive host...
  36. Ben Yishay A, Fraker A, Guiteras R, Palloni G, Shah N, Shirrell S, et al. Microcredit and willingness to pay for environmental quality: Evidence from a randomized-controlled trial of finance for sanitation in rural Cambodia. J Environ Econ Manage. 2017;86:121-140 pubmed publisher
    ..Effects on latrine installation are positive but muted by several factors, including a negative peer effect: randomly induced purchases by neighbors reduce a household's ..
  37. Antonio Flores J, Almansa Martínez M, Pina Roche F, Lozano Martínez M, Lucas Martínez A, Frapolli Gómez G. [NURSING DIAGNOSIS PROPOSAL FOR GENDER VIOLENCE SYNDROME IN NANDA-I TAXONOMY]. Rev Enferm. 2015;38:28-32 pubmed
    Gender-based violence is a widespread and muted problem in public health that particularly affects millions of women worldwide...
  38. N guessan Kouassi K, Riccardo A, Dutoziet Christian C, André G, Férilaha C, Hortense S, et al. Genotyping of mutations detected with GeneXpert. Int J Mycobacteriol. 2016;5:142-7 pubmed publisher
    ..The strains muted in rpoB without a specific protein identified and were sequenced...
  39. Kroeger N, Stenzl A, Burchardt M, Bedke J. Adjuvant Treatment of High-risk Renal Cell Carcinoma: Leaving the Desert?. Eur Urol. 2017;71:695-696 pubmed publisher
    ..This positive result is muted by the rate of side effects and overtreatment, raising the question of proper patient and agent selection in the ..
  40. Haque M, Tejero J, Bayachou M, Kenney C, Stuehr D. A cross-domain charge interaction governs the activity of NO synthase. J Biol Chem. 2018;293:4545-4554 pubmed publisher
    ..Full recovery of heme reduction was probably muted by an accompanying change in FMN midpoint potential that made electron transfer to the heme thermodynamically ..
  41. Bay R, Palumbi S. Rapid Acclimation Ability Mediated by Transcriptome Changes in Reef-Building Corals. Genome Biol Evol. 2015;7:1602-12 pubmed publisher
    ..Across these contigs, corals acclimated to higher temperatures (31 °C or 29-33 °C) exhibited a muted stress response--the magnitude of expression change before and after heat stress was less than in 29 °C ..
  42. Ahuja S, Manoharan M, Harper N, Jimenez F, Hobson B, Martinez H, et al. Preservation of epithelial cell barrier function and muted inflammation in resistance to allergic rhinoconjunctivitis from house dust mite challenge. J Allergy Clin Immunol. 2017;139:844-854 pubmed publisher
    ..protein [filaggrin]) versus inflammation (eg, chemokines) and innate immunity (interferon) were upregulated versus muted, respectively...
  43. Sharma K, Mudgil P, Whitehall J, Gosbell I. Aggregatibacter actinomycetemcomitans osteomyelitis in a 12 year old boy: case report emphasizing the importance of tissue culture, and review of literature. Ann Clin Microbiol Antimicrob. 2017;16:12 pubmed publisher
    ..It occurred in the toe, without obvious dental predisposition; associated with minimal clinical disturbance and with muted immune response.
  44. Calderon G, Thai P, Hsu C, Grigoryan B, Gibson S, Dickinson M, et al. Tubulogenesis of co-cultured human iPS-derived endothelial cells and human mesenchymal stem cells in fibrin and gelatin methacrylate gels. Biomater Sci. 2017;5:1652-1660 pubmed publisher
    ..We find that iPS-ECs alone have a muted tubulogenic response within GelMA, but that their tubulogenic response is enhanced when they are co-cultured with ..
  45. Connor S, Ammendrup Johnsen I, Kishimoto Y, Karimi Tari P, Cvetkovska V, Harada T, et al. Loss of Synapse Repressor MDGA1 Enhances Perisomatic Inhibition, Confers Resistance to Network Excitation, and Impairs Cognitive Function. Cell Rep. 2017;21:3637-3645 pubmed publisher
    ..Mdga1-/- hippocampal networks demonstrate muted responses to neural excitation, and Mdga1-/- mice are resistant to induced seizures...
  46. Bollampalli V, Harumi Yamashiro L, Feng X, Bierschenk D, Gao Y, Blom H, et al. BCG Skin Infection Triggers IL-1R-MyD88-Dependent Migration of EpCAMlow CD11bhigh Skin Dendritic cells to Draining Lymph Node During CD4+ T-Cell Priming. PLoS Pathog. 2015;11:e1005206 pubmed publisher
    ..Consequently, blockade of skin DC traffic into DLN dramatically reduced mycobacterial entry into DLN and muted T-cell priming...
  47. King B, Yin V. A Conserved MicroRNA Regulatory Circuit Is Differentially Controlled during Limb/Appendage Regeneration. PLoS ONE. 2016;11:e0157106 pubmed publisher
    ..For instance, complex limb/appendage regeneration is muted in mammals but enhanced in amphibians and teleosts...
  48. Tong L, Ye K, Asai K, Ertaç S, List J, Nusbaum H, et al. Trading experience modulates anterior insula to reduce the endowment effect. Proc Natl Acad Sci U S A. 2016;113:9238-43 pubmed publisher
    ..The endowment effect has been found to be muted among experienced traders, but little is known about how trading experience reduces the endowment effect...
  49. Zhou Y, Chen H, Liu L, Yu X, Sukhova G, Yang M, et al. CD74 Deficiency Mitigates Systemic Lupus Erythematosus-like Autoimmunity and Pathological Findings in Mice. J Immunol. 2017;198:2568-2577 pubmed publisher
    ..Splenocytes from CD74-deficient FaslprCd74-/- mice had muted responses in a MLR and to the autoantigen histones...
  50. Mohammadi S, Burton T, Christie M. α9-nAChR knockout mice exhibit dysregulation of stress responses, affect and reward-related behaviour. Behav Brain Res. 2017;328:105-114 pubmed publisher
    ..Physiologically, corticosterone responses were muted in knockout mice after an acute stressor, but exaggerated in response to the same stressor after undergoing sub-..
  51. Caserta S, Nausch N, Sawtell A, Drummond R, Barr T, MacDonald A, et al. Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells. PLoS ONE. 2012;7:e35466 pubmed publisher
    ..T cell responses in these conditions become muted despite ongoing infection...
  52. Jacobs K, Misri S, Meyer B, Raj S, Zobel C, Sleckman B, et al. Unique epigenetic influence of H2AX phosphorylation and H3K56 acetylation on normal stem cell radioresponses. Mol Biol Cell. 2016;27:1332-45 pubmed publisher
    ..Of interest, they also exhibited a uniquely attenuated DNA damage response (DDR) and muted DNA repair...
  53. Cui Q, Fu J, Hu Y, Li Y, Yang B, Li L, et al. Deficiency of long isoforms of Nfe2l1 sensitizes MIN6 pancreatic ? cells to arsenite-induced cytotoxicity. Toxicol Appl Pharmacol. 2017;329:67-74 pubmed publisher
    ..pancreatic ?-cells were vulnerable to cell damage induced by oxidative stressors including arsenite, due to a muted antioxidant response...
  54. Kokiko Cochran O, Ransohoff L, Veenstra M, Lee S, Saber M, Sikora M, et al. Altered Neuroinflammation and Behavior after Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease. J Neurotrauma. 2016;33:625-40 pubmed publisher
    ..Unexpectedly, in R1.40 mice, the acute neuroinflammatory response to TBI was strikingly muted, with reduced numbers of CNS myeloid cells acquiring a macrophage phenotype and decreased expression of ..
  55. Fanou E, Knight J, Aviv R, Hojjat S, Symons S, Zhang L, et al. Effect of Collaterals on Clinical Presentation, Baseline Imaging, Complications, and Outcome in Acute Stroke. AJNR Am J Neuroradiol. 2015;36:2285-91 pubmed publisher
    ..was superior to that of total ischemic volume for hemorrhagic transformation and final infarct prediction but was muted compared with patients who were recanalization negative (11.3% and 16.9% variability)...
  56. Zhang Q, Koser S, Donkin S. Propionate induces the bovine cytosolic phosphoenolpyruvate carboxykinase promoter activity. J Dairy Sci. 2016;99:6654-6664 pubmed publisher
    ..5 mM propionate, which was not muted by 100 nM insulin. Activity of the PCK1 promoter was increased 1-fold by either 1.0 mM cAMP or 5...
  57. Hao Z, Li W. Muted protein is involved in the targeting of CD63 to large dense-core vesicles of chromaffin cells. Yi Chuan. 2016;38:718-23 pubmed publisher
    ..The Muted protein is a subunit of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), which functions in the ..
  58. Spruit E, Band G, Van der Heijden K, Hamming J. The Effects of Spacing, Naps, and Fatigue on the Acquisition and Retention of Laparoscopic Skills. J Surg Educ. 2017;74:530-538 pubmed publisher
    ..Breaks with sleep opportunity (i.e., lying, inactive, and muted sensory input) enhance performance over training with regular breaks and traditional massed training.
  59. Ide J, Nedic S, Wong K, Strey S, Lawson E, Dickerson B, et al. Oxytocin attenuates trust as a subset of more general reinforcement learning, with altered reward circuit functional connectivity in males. Neuroimage. 2018;174:35-43 pubmed publisher
    ..Neurobiologically, reduced learning under OT was associated with muted communication between three key nodes within the reward circuit: the orbitofrontal cortex, amygdala, and lateral (..
  60. Liang S. Sepsis and Other Infectious Disease Emergencies in the Elderly. Emerg Med Clin North Am. 2016;34:501-22 pubmed publisher
    ..Clinical presentations are often atypical and muted, favoring global changes in mental status and function over febrile responses or localizing symptoms...
  61. Jones T, Smith A, Macnaughton L, French D. Strength and Conditioning and Concurrent Training Practices in Elite Rugby Union. J Strength Cond Res. 2016;30:3354-3366 pubmed
    ..Thirty-three (77%) practitioners indicated that the potential muted strength development associated with concurrent training was considered when programming and 27 (63%) believed ..
  62. Jacobs P, Banthin J, Trachtman S. Insurer Competition In Federally Run Marketplaces Is Associated With Lower Premiums. Health Aff (Millwood). 2015;34:2027-35 pubmed publisher
    ..We found that the effect of insurer entry was muted after two or three additional entrants...
  63. Hwang E, Song S. Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells. Cell Mol Life Sci. 2017;74:3347-3362 pubmed publisher
    ..with NAM was used to inhibit SIRT1 and found that the expected inhibitory effect of NAM was either unreliable or muted in many cases...
  64. Ray K, Drnach M, Mehrotra A, Suresh S, Docimo S. Impact of Implementation of Electronically Transmitted Referrals on Pediatric Subspecialty Visit Attendance. Acad Pediatr. 2018;18:409-417 pubmed publisher
    ..attendance after pediatric subspecialty referral, the sizable percentage of children without attended visits, the muted effect at control practices, and pediatrician survey responses indicate that additional work is needed to address ..
  65. Shaw P, Chaotheing S, Kaewprommal P, Piriyapongsa J, Wongsombat C, Suwannakitti N, et al. Plasmodium parasites mount an arrest response to dihydroartemisinin, as revealed by whole transcriptome shotgun sequencing (RNA-seq) and microarray study. BMC Genomics. 2015;16:830 pubmed publisher
    ..RNA-seq data from DHA-treated P. falciparum rings reveal a more muted response, although there is considerable overlap of differentially expressed genes with DHA-treated trophozoites...
  66. Shurtz I, Brzezinski A, Frumkin A. The impact of financing of screening tests on utilization and outcomes: The case of amniocentesis. J Health Econ. 2016;48:61-73 pubmed publisher
    ..whereas below the age-35 threshold amniocentesis utilization rates increase with maternal age, this relation is muted above this age...
  67. Chu L, Tu M, Lee Y, Sood N. The impact of patient-centered medical homes on safety net clinics. Am J Manag Care. 2016;22:532-8 pubmed
    ..However, the beneficial effects of the PCMH model can be muted by a sudden influx of high-need users.
  68. Morris D, Murphy K, Kenny N, PURCELL S, McGhee K, Schwaiger S, et al. Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility. Biol Psychiatry. 2008;63:24-31 pubmed
    ..A systematic investigation of the other seven BLOC-1 genes (MUTED, PLDN, CNO, SNAPAP, BLOC1S1, BLOC1S2, and BLOC1S3) for evidence of association with SZ was undertaken in a sample ..
  69. Quinti L, Dayalan Naidu S, Träger U, Chen X, Kegel Gleason K, Lleres D, et al. KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients. Proc Natl Acad Sci U S A. 2017;114:E4676-E4685 pubmed publisher
    ..Surprisingly, we discovered a muted NRF2 activation response in human HD neural stem cells, which was restored by genetic correction of the disease-..
  70. Luna G, Keeley P, Reese B, Linberg K, Lewis G, Fisher S. Astrocyte structural reactivity and plasticity in models of retinal detachment. Exp Eye Res. 2016;150:4-21 pubmed publisher
    ..mouse presents a convenient model system in which to study astrocyte reactivity since the M?ller cell response is muted in comparison to other species thereby allowing better visualization of the astrocytes...
  71. Wegehaupt A, Wagner W. Females can solve the problem of low signal reliability by assessing multiple male traits. Biol Lett. 2017;13: pubmed publisher
    ..We paired females with muted males that were maintained on low or high nutrition diets, during the interactions we broadcast a replacement high ..
  72. Talior Volodarsky I, Mahou R, Zhang D, SEFTON M. The role of insulin growth factor-1 on the vascular regenerative effect of MAA coated disks and macrophage-endothelial cell crosstalk. Biomaterials. 2017;144:199-210 pubmed publisher
    ..methyl methacrylate-co-IDA) disks; the latter did not generate a vascular response and the polarization shift was muted with AG1024...
  73. Zhang Q, Li W, Novak E, Karim A, Mishra V, Kingsmore S, et al. The gene for the muted (mu) mouse, a model for Hermansky-Pudlak syndrome, defines a novel protein which regulates vesicle trafficking. Hum Mol Genet. 2002;11:697-706 pubmed
    The muted (mu) mouse is a model for Hermansky-Pudlak Syndrome (HPS), an inherited disorder of humans causing hypopigmentation, hemorrhaging and early death due to lung abnormalities...
  74. Dharan N, Farago O. Interplay between membrane elasticity and active cytoskeleton forces regulates the aggregation dynamics of the immunological synapse. Soft Matter. 2017;13:6938-6946 pubmed publisher
    ..The agreement is lost when one of the aggregation mechanisms is "muted", which helps to identify their respective roles in the process...
  75. Kadyrov A, Bray I, Charlton M, Fabrikant I. Quantum suppression of antihydrogen formation in positronium-antiproton scattering. Nat Commun. 2017;8:1544 pubmed publisher
    ..Contrary to expectation from earlier work, there are only muted increases in the cross-sections for antihydrogen formation for n i > 3...
  76. Ciciotte S, Gwynn B, Moriyama K, Huizing M, Gahl W, Bonifacino J, et al. Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1). Blood. 2003;101:4402-7 pubmed
    ..of lysosome-related organelles complex-1), consisting of the proteins encoded at 2 mouse HPS loci, pallid (pa) and muted (mu), and at least 3 other unidentified proteins...
  77. Wright N, Wessel R. Network activity influences the subthreshold and spiking visual responses of pyramidal neurons in the three-layer turtle cortex. J Neurophysiol. 2017;118:2142-2155 pubmed publisher
    ..Responses were muted when immediately preceded by large, spontaneous Up states...
  78. Shah S, Ganesan S, Varadharaj S, Dabdoub S, Walters J, Kumar P. The making of a miscreant: tobacco smoke and the creation of pathogen-rich biofilms. NPJ Biofilms Microbiomes. 2017;3:26 pubmed publisher
    ..and amplified pro-inflammatory and oxidative stress response to these virulence-enhanced commensal biofilms, and a muted early response to pathogen-rich biofilms. Commensal biofilms also demonstrated early and widespread cell death...
  79. Stradner M, Cheung K, Lasorella A, Goldrath A, D Cruz L. Id2 regulates hyporesponsive invariant natural killer T cells. Immunol Cell Biol. 2016;94:640-5 pubmed publisher
    ..with the glycolipid, ?-galactosylceramide (?GalCer), is robust, the secondary response to this stimulus is muted resulting in a hyporesponsive state characterized by anti-inflammatory interleukin-10 (IL-10) production and high ..
  80. Cheok C, Lane D. Exploiting the p53 Pathway for Therapy. Cold Spring Harb Perspect Med. 2017;7: pubmed publisher
    The excitement around the entry into the clinic of the first generation of p53-specific drugs has become muted as the hoped-for dramatic clinical responses have not yet been seen...
  81. Smith Greenaway E, Clark S. Variation in the link between parental divorce and children's health disadvantage in low and high divorce settings. SSM Popul Health. 2017;3:473-486 pubmed publisher
    ..the childhood health disadvantage is accentuated in subnational African regions where fewer women are divorced and muted in areas where more women are divorced...
  82. Hong J, Jonsson Funk M, LoCasale R, Dempster S, Cole S, Webster Clark M, et al. Generalizing Randomized Clinical Trial Results: Implementation and Challenges Related to Missing Data in the Target Population. Am J Epidemiol. 2017;: pubmed publisher
    ..0% (95% confidence interval (CI): -2.9, -1.1). The rosuvastatin effect was muted in the first 2 years but remained strong at 3 years after standardizing to the imputed CPRD population (3-year RD: ..
  83. Starcevic M, Dell Angelica E. Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1). J Biol Chem. 2004;279:28393-401 pubmed
    ..The complex is known to contain the coiled-coil-forming proteins, Pallidin, Muted, Cappuccino, and Dysbindin...
  84. Funder J. Primary Aldosteronism: The Next Five Years. Horm Metab Res. 2017;: pubmed publisher
    ..for complete/partial/absent cure after adrenalectomy for unilateral disease; again focus on bilateral disease is muted. A number of possibilities are suggested as agenda for active consideration and change, across a wide range of ..
  85. Corrigan P. Beware the Educational Fix: Limitations of Efforts to Promote Mental Health Literacy. Psychiatr Serv. 2017;:appips201700236 pubmed publisher
    ..Despite its promise, however, educational approaches may have muted effects. Students in discrete training programs are often overwhelmed by too much information...
  86. Setty S, Tenza D, Truschel S, Chou E, Sviderskaya E, Theos A, et al. BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles. Mol Biol Cell. 2007;18:768-80 pubmed
  87. Tagliabue A, Resing J. Impact of hydrothermalism on the ocean iron cycle. Philos Trans A Math Phys Eng Sci. 2016;374: pubmed publisher
    ..Atlantic and Pacific basins, which when combined with the inter-basin contrasts in oxidation kinetics suggests a muted influence of Atlantic ridges on the Southern Ocean biological carbon pump...
  88. Schwartz C, Lee J, Amasino R. Variation in shade-induced flowering in Arabidopsis thaliana results from FLOWERING LOCUS T allelic variation. PLoS ONE. 2017;12:e0187768 pubmed publisher
    ..The genetic basis of the muted response to FR enrichment was studied in three accessions (Fl-1, Hau-0, and Mir-0)...
  89. Singh A, Rahman T, Bartiss R, Arabshahi A, Prasain J, Barnes S, et al. Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemia. J Leukoc Biol. 2017;101:531-542 pubmed publisher
    Respiratory infection with Francisella tularensis (Ft) is characterized by a muted, acute host response, followed by sepsis-like syndrome that results in death...
  90. Kipp M, Stüeken E. Biomass recycling and Earth's early phosphorus cycle. Sci Adv. 2017;3:eaao4795 pubmed publisher
    ..We propose that the size of the marine phosphorus reservoir was instead constrained by muted liberation of phosphorus during the remineralization of biomass...
  91. Falcon Perez J, Starcevic M, Gautam R, Dell Angelica E. BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules. J Biol Chem. 2002;277:28191-9 pubmed
    ..Two of these genes, which are defective in the pallid and muted mutant mouse strains, encode small, coiled-coil-forming proteins that display no homology to each other or to any ..
  92. Li W, Zhang Q, Oiso N, Novak E, Gautam R, O Brien E, et al. Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Nat Genet. 2003;35:84-9 pubmed
    ..9-11), which regulates trafficking to lysosome-related organelles and includes the proteins pallidin, muted and cappuccino, which are associated with HPS in mice...