Gene Symbol: BLOC1S4
Description: biogenesis of lysosomal organelles complex 1 subunit 4
Alias: BCAS4L, BLOS4, CNO, biogenesis of lysosome-related organelles complex 1 subunit 4, BLOC-1 subunit 4, biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino, cappuccino homolog, protein cappuccino homolog
Species: human
Products:     BLOC1S4

Top Publications

  1. Coutinho E, Okamoto S, Ishikawa A, Yokota S, Wada N, Hirabayashi T, et al. Activation of SF1 Neurons in the Ventromedial Hypothalamus by DREADD Technology Increases Insulin Sensitivity in Peripheral Tissues. Diabetes. 2017;66:2372-2386 pubmed publisher
    ..Activation of SF1 neurons by an intraperitoneal injection of clozapine-N-oxide (CNO), a specific hM3Dq ligand, reduced food intake and increased energy expenditure in mice expressing hM3Dq in SF1 ..
  2. Buchta W, Mahler S, Harlan B, Aston Jones G, Riegel A. Dopamine terminals from the ventral tegmental area gate intrinsic inhibition in the prefrontal cortex. Physiol Rep. 2017;5: pubmed publisher
    ..stimulation of VTA terminals with either blue light to activate ChR2 or bath application of clozapine-N-oxide (CNO) to activate Gq-DREADDs produced a similar reduction in intrinsic inhibition in PL neurons...
  3. Gompf H, Budygin E, Fuller P, Bass C. Targeted genetic manipulations of neuronal subtypes using promoter-specific combinatorial AAVs in wild-type animals. Front Behav Neurosci. 2015;9:152 pubmed publisher
    ..IHC revealed that the area of c-fos activation after CNO treatment in the LC and peri-LC neurons appeared proportional to the resulting increase in wakefulness (non-..
  4. den Hartog C, Zamudio Bulcock P, Nimitvilai S, Gilstrap M, Eaton B, Fedarovich H, et al. Inactivation of the lateral orbitofrontal cortex increases drinking in ethanol-dependent but not non-dependent mice. Neuropharmacology. 2016;107:451-459 pubmed publisher
    ..Consistent with the lesion study, treatment with clozapine-N-oxide (CNO) further enhanced consumption only in CIE exposed DREADD mice with no change in air-treated mice...
  5. Sugasini D, Lokesh B. Curcumin and linseed oil co-delivered in phospholipid nanoemulsions enhances the levels of docosahexaenoic acid in serum and tissue lipids of rats. Prostaglandins Leukot Essent Fatty Acids. 2017;119:45-52 pubmed publisher
    ..Curcumin was dissolved in coconut oil (CNO, MCFA rich), Sunflower oil (SNO, n-6 PUFA rich) or Linseed oil (LSO, n-3 PUFA rich) and nanoemulsions were prepared ..
  6. Naganuma F, Bandaru S, Absi G, Mahoney C, Scammell T, Vetrivelan R. Melanin-concentrating hormone neurons contribute to dysregulation of rapid eye movement sleep in narcolepsy. Neurobiol Dis. 2018;120:12-20 pubmed publisher
    ..In both lines of mice, activation of MCH neurons by clozapine-N-oxide (CNO) increased rapid eye movement (REM) sleep without altering other states...
  7. Wang C, Yang Y, Yuan F, Li H, He L, Liu D, et al. Initiation Condition of Hemodialysis Is Independently Associated with All-Cause Mortality in Maintenance Hemodialysis Patients: A Retrospective Study. Blood Purif. 2019;:1-10 pubmed publisher
    ..Video Journal Club "Cappuccino with Claudio Ronco" at ..
  8. Fitzpatrick C, Runegaard A, Christiansen S, Hansen N, Jørgensen S, McGirr J, et al. Differential effects of chemogenetic inhibition of dopamine and norepinephrine neurons in the mouse 5-choice serial reaction time task. Prog Neuropsychopharmacol Biol Psychiatry. 2019;90:264-276 pubmed publisher
    ..At the highest clozapine N-oxide (CNO) dose tested (i.e. 2 mg/kg) to activate hM4Di, we detected a reduction in locomotor activity...
  9. Zhang T, Deyama S, Domoto M, Wada S, Yanagida J, Sasase H, et al. Activation of GABAergic Neurons in the Nucleus Accumbens Mediates the Expression of Cocaine-Associated Memory. Biol Pharm Bull. 2018;41:1084-1088 pubmed publisher
    ..Ex vivo electrophysiological recordings revealed that bath application of clozapine-N-oxide (CNO) significantly hyperpolarized membrane potentials and reduced the number of spikes induced by depolarizing current ..

More Information

Publications125 found, 100 shown here

  1. Sosińska Zawierucha P, Baum E, Maćkowiak B, Misian M, Breborowicz A. Different Effect of Hemodialysis on Function of Human Arterial and Venous Endothelial Cells. Blood Purif. 2018;:1-5 pubmed publisher
    ..Video Journal Club 'Cappuccino with Claudio Ronco' at ..
  2. Chang C, Nashchekin D, Wheatley L, Irion U, Dahlgaard K, Montague T, et al. Anterior-posterior axis specification in Drosophila oocytes: identification of novel bicoid and oskar mRNA localization factors. Genetics. 2011;188:883-96 pubmed publisher
  3. Saund J, Dautan D, Rostron C, Urcelay G, Gerdjikov T. Thalamic inputs to dorsomedial striatum are involved in inhibitory control: evidence from the five-choice serial reaction time task in rats. Psychopharmacology (Berl). 2017;234:2399-2407 pubmed publisher
    ..The DREADD agonist, clozapine N-oxide (CNO; 1 μl bilateral; 3 μM) or vehicle, was injected into DMS 1 h before behavioural testing...
  4. Sok V, Fragoso A. Preparation and characterization of alkaline phosphatase, horseradish peroxidase and glucose oxidase conjugates with carboxylated carbon nano-onions. Prep Biochem Biotechnol. 2017;: pubmed publisher
    ..The CNO-enzyme conjugates were characterized by TEM and Raman spectroscopy...
  5. Hayes M, Bryon K, Satkurunathan J, Levine T. Yeast homologues of three BLOC-1 subunits highlight KxDL proteins as conserved interactors of BLOC-1. Traffic. 2011;12:260-8 pubmed publisher
    ..cerevisiae: Blos1, snapin and cappuccino (cno)...
  6. Anderson R, Lopez M, Griffin W, Haun H, Bloodgood D, Pati D, et al. Dynorphin-kappa opioid receptor activity in the central amygdala modulates binge-like alcohol drinking in mice. Neuropsychopharmacology. 2019;44:1084-1092 pubmed publisher
    ..Activating the inhibitory DREADD by CNO injection reduced binge-like alcohol drinking, but CNO injection did not alter alcohol intake in mice that were ..
  7. Hamada Kawaguchi N, Yamamoto D. Ovarian polarity and cell shape determination by Btk29A in Drosophila. Genesis. 2017;55: pubmed publisher
    ..It is proposed that Btk29A is required for the establishment of egg chamber polarity presumably through the regulation of subcellular localization of its downstream proteins, including Cno.
  8. Pina M, Young E, Ryabinin A, Cunningham C. The bed nucleus of the stria terminalis regulates ethanol-seeking behavior in mice. Neuropharmacology. 2015;99:627-38 pubmed publisher
    ..of inhibitory designer receptors exclusively activated by designer drugs (hM4Di-DREADD) with clozapine-N-oxide (CNO; Experiment 3). The magnitude of ethanol CPP was reduced significantly by each of these techniques...
  9. Rizo Topete L, Rosner M, Ronco C. Acute Kidney Injury Risk Assessment and the Nephrology Rapid Response Team. Blood Purif. 2017;43:82-88 pubmed publisher
    ..Integration of these assessment tools in a global methodology that includes a multi-disciplinary team (NRRT) is critical to success. Video Journal Club 'Cappuccino with Claudio Ronco' at ..
  10. Runegaard A, Fitzpatrick C, Woldbye D, Andreasen J, Sørensen A, Gether U. Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progress, and Challenges. Pharmacol Rev. 2019;71:123-156 pubmed publisher
    ..associated with the chemogenetic technology, such as the metabolism of the DREADD ligand clozapine N-oxide (CNO) to the D2 receptor antagonist clozapine...
  11. Kolosowski K, Sodhi R, Kishen A, Basrani B. Qualitative Time-of-Flight Secondary Ion Mass Spectrometry Analysis of Root Dentin Irrigated with Sodium Hypochlorite, EDTA, or Chlorhexidine. J Endod. 2015;41:1672-7 pubmed publisher
    ..Sample A revealed intense peaks characteristics of hydroxyapatite in addition to Na(+), K(+), CH4N(+), CN(-), CNO(-), Mg(+), F(-), and HCO2(-) peaks. Sample B showed severely decreased CH4N(+) and increased intensity of Cl(-)...
  12. Singh H, Mishra B. Degradation of cyanide, aniline and phenol in pre-treated coke oven wastewater by peroxide assisted electro-oxidation process. Water Sci Technol. 2018;78:2214-2227 pubmed publisher
    ..The advanced oxidation process degrades the more toxic cyanide into less toxic intermediate cyanate ions (CNO), which further cut down into nontoxic end products such as N2, HCO3 and CO..
  13. Jones M, Paniccia J, Lebonville C, Reissner K, Lysle D. Chemogenetic Manipulation of Dorsal Hippocampal Astrocytes Protects Against the Development of Stress-enhanced Fear Learning. Neuroscience. 2018;388:45-56 pubmed publisher
    ..Specifically, we find that CNO (clozapine-n-oxide) significantly attenuated colocalization of the Gi-coupled DREADD receptor and cyclic ..
  14. Mekuto L, Ntwampe S, Akcil A. An integrated biological approach for treatment of cyanidation wastewater. Sci Total Environ. 2016;571:711-20 pubmed publisher
    ..metallic complexes with iron, nickel, copper, zinc, cobalt and other metals; thiocyanate (SCN); and cyanate (CNO)...
  15. Arico C, Bagley E, Carrive P, Assareh N, McNally G. Effects of chemogenetic excitation or inhibition of the ventrolateral periaqueductal gray on the acquisition and extinction of Pavlovian fear conditioning. Neurobiol Learn Mem. 2017;144:186-197 pubmed publisher
    ..effects on fear and extinction learning were specific to the combination of DREADD expression and injection of CNO because they were observed relative to both eYFP controls injected with CNO as well as DREADD expressing controls ..
  16. Ronco C, Ricci Z, Husain Syed F. From Multiple Organ Support Therapy to Extracorporeal Organ Support in Critically Ill Patients. Blood Purif. 2019;:1-7 pubmed publisher
    ..Video Journal Club "Cappuccino with Claudio Ronco" at ..
  17. Wulaer B, Nagai T, Sobue A, Itoh N, Kuroda K, Kaibuchi K, et al. Repetitive and compulsive-like behaviors lead to cognitive dysfunction in Disc1Δ2-3/Δ2-3 mice. Genes Brain Behav. 2018;17:e12478 pubmed publisher
    ..The treatment of mice that had previously expressed hM3Dq in the DMS with clozapine-N-oxide (CNO) impaired performance in the VD task...
  18. Kucinski A, Kim Y, Sarter M. Basal forebrain chemogenetic inhibition disrupts the superior complex movement control of goal-tracking rats. Behav Neurosci. 2019;133:121-134 pubmed publisher
    ..Administration of clozapine-N-oxide (CNO) had no significant effect in GTs not expressing the DREADD...
  19. Bartelmess J, Baldrighi M, Nardone V, Parisini E, Buck D, Echegoyen L, et al. Synthesis and Characterization of Far-Red/NIR-Fluorescent BODIPY Dyes, Solid-State Fluorescence, and Application as Fluorescent Tags Attached to Carbon Nano-onions. Chemistry. 2015;21:9727-32 pubmed publisher
    ..The far-red/NIR-fluorescent CNO nanoparticles were characterized by absorption, fluorescence, and Raman spectroscopies, as well as by ..
  20. McKelvey K, BAIOCCHI M, Ramamurthi D, McLaughlin S, Halpern Felsher B. Youth say ads for flavored e-liquids are for them. Addict Behav. 2019;91:164-170 pubmed publisher
    ..Findings support the need to regulate flavored e-liquids and associated ads to reduce youth appeal, which ultimately could reduce youth use of e-cigarettes. ..
  21. Sakulthaew C, Comfort S, Chokejaroenrat C, Li X, Harris C. Removing PAHs from urban runoff water by combining ozonation and carbon nano-onions. Chemosphere. 2015;141:265-73 pubmed publisher
    ..e., non-ozonated) were not biologically degraded following CNO adsorption and that O3-transformed PAHs were not released from the CNOs in the absence of bacteria...
  22. Wirtshafter D, Stratford T. Chemogenetic inhibition of cells in the paramedian midbrain tegmentum increases locomotor activity in rats. Brain Res. 2016;1632:98-106 pubmed publisher
    ..We found that the DREADD ligand clozapine-N-oxide (CNO) increased locomotor activity in animals expressing the inhibitory DREADD hM4Di, but not those injected with a ..
  23. Luo X, Xiao Y, Wu Q, Zeng J. Development of high-performance biodegradable rigid polyurethane foams using all bioresource-based polyols: Lignin and soy oil-derived polyols. Int J Biol Macromol. 2018;115:786-791 pubmed publisher
    ..bonds between soy-based polyurethane and lignin, and the lignin powders can react with pMDI via active -H and -CNO. In addition, hydrogen bonding also plays an important role in forming the 3D structures...
  24. Koehler S, Brähler S, Kuczkowski A, Binz J, Hackl M, Hagmann H, et al. Single and Transient Ca2+ Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion. Sci Rep. 2016;6:35400 pubmed publisher
    ..Activation of the engineered G-protein coupled receptor with the synthetic compound clozapine-N-oxide (CNO) evoked a short and transient Ca2+ peak in podocytes immediately after CNO administration in vivo...
  25. Ziobrowska Bech A, Herlin T. [Autoinflammatory bone disorders in childhood]. Ugeskr Laeger. 2014;176:1367-70 pubmed
    Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory disease with unpredictable, painful courses of osteolytic lesions in the bones. CNO is frequently associated with psoriasis and inflammatory bowel disease...
  26. de la Calle I, Menta M, Klein M, Seby F. Study of the presence of micro- and nanoparticles in drinks and foods by multiple analytical techniques. Food Chem. 2018;266:133-145 pubmed publisher
    ..Ti-containing NPs (80-200 nm) were found in chewing gum and Ag NPs in silver pearls (50-150 nm) used for decoration pastry. ..
  27. Chen Y, Xiong M, Dong Y, Haberman A, Cao J, Liu H, et al. Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson's Disease. Cell Stem Cell. 2016;18:817-26 pubmed publisher
    ..Administering clozapine-N-oxide (CNO) enabled precise DREADD-dependent stimulation or inhibition of engrafted neurons, revealing D1 receptor-dependent ..
  28. Marada S, Truong A, Ogden S. The small GTPase Rap1 is a modulator of Hedgehog signaling. Dev Biol. 2016;409:84-94 pubmed publisher
    ..The Rap1 effector Canoe (Cno) also impacts Hh signal output, suggesting that a C3G-Rap1-Cno axis intersects the Hh pathway during tissue ..
  29. Zhao Y, Ferguson P. Chronic Nonbacterial Osteomyelitis and Chronic Recurrent Multifocal Osteomyelitis in Children. Pediatr Clin North Am. 2018;65:783-800 pubmed publisher
    Chronic nonbacterial osteomyelitis (CNO) is an innate immune system disorder that predominantly affects children. It can present as part of a syndrome or in isolation...
  30. Miao C, Cao Q, Ito H, Yamahachi H, Witter M, Moser M, et al. Hippocampal Remapping after Partial Inactivation of the Medial Entorhinal Cortex. Neuron. 2015;88:590-603 pubmed publisher
    ..was expressed in MEC, and place cells were recorded after application of the inert ligand clozapine-N-oxide (CNO) or light at appropriate wavelengths. CNO or light caused partial inactivation of the MEC...
  31. Wess J, Nakajima K, Jain S. Novel designer receptors to probe GPCR signaling and physiology. Trends Pharmacol Sci. 2013;34:385-92 pubmed publisher bind acetylcholine, the endogenous muscarinic receptor agonist, but can be activated by clozapine-N-oxide (CNO), an otherwise pharmacologically inert compound, with high potency and efficacy...
  32. Hofmann S, Böttger F, Range U, Lück C, Morbach H, Girschick H, et al. Serum Interleukin-6 and CCL11/Eotaxin May Be Suitable Biomarkers for the Diagnosis of Chronic Nonbacterial Osteomyelitis. Front Pediatr. 2017;5:256 pubmed publisher
    Chronic recurrent multifocal osteomyelitis (CRMO), the most severe form of chronic nonbacterial osteomyelitis (CNO), is an autoinflammatory bone disorder...
  33. Kashani K, Ronco C. Acute Kidney Injury Electronic Alert for Nephrologist: Reactive versus Proactive?. Blood Purif. 2016;42:323-328 pubmed
    ..Video Journal Club 'Cappuccino with Claudio Ronco' at ..
  34. Varela C, Weiss S, Meyer R, Halassa M, Biedenkapp J, Wilson M, et al. Tracking the Time-Dependent Role of the Hippocampus in Memory Recall Using DREADDs. PLoS ONE. 2016;11:e0154374 pubmed publisher
    ..recent (1-2 days after acquisition) contextual fear memories can be recalled after injection of the DREADD agonist (CNO) in animals expressing the inhibitory DREADD in the entire hippocampus...
  35. Manawi Y, Samara A, Al Ansari T, Atieh M. A Review of Carbon Nanomaterials' Synthesis via the Chemical Vapor Deposition (CVD) Method. Materials (Basel). 2018;11: pubmed publisher
    ..carbon nanotubes (CNTs), carbon nanofibers (CNFs), graphene, carbide-derived carbon (CDC), carbon nano-onion (CNO) and MXenes...
  36. Gao Y, Pan Y, Chi Y, He Y, Chen H, Nemykin V. A "reactive" turn-on fluorescence probe for hypochlorous acid and its bioimaging application. Spectrochim Acta A Mol Biomol Spectrosc. 2019;206:190-196 pubmed publisher
    ..aldoxime-based aza-BODIPY-CNOH probe into the red-fluorescence, nitrile oxide-based aza-BODIPY compound aza-BODIPY-CNO. The aza-BODIPY-CNOH probe showed good biocompatibility and was low toxic to living cells as shown from MTT ..
  37. Zhao Y, Wu E, Oliver M, Cooper A, Basiaga M, Vora S, et al. Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Anti-Inflammatory Drugs and/or with Active Spinal Lesions. Arthritis Care Res (Hoboken). 2017;: pubmed publisher
    To develop standardized treatment regimens for chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO) to enable comparative effectiveness treatment studies.
  38. Schoster Meade S, Gormley D. CNO Rounding Using an Electronic Tracking Tool: Closing the Loop. J Nurs Adm. 2018;48:E1-E4 pubmed publisher
    ..This article summarizes an innovative closed feedback loop using an electronic record incorporated into chief nursing officer rounding and the impact on NDNQI survey results. ..
  39. Roucel M, Grau F. The importance of new molecules in selective perfumery. Chem Biodivers. 2014;11:1462-9 pubmed publisher
  40. Palaniappan B, Sundaram U. Direct and specific inhibition of constitutive nitric oxide synthase uniquely regulates brush border membrane Na-absorptive pathways in intestinal epithelial cells. Nitric Oxide. 2018;79:8-13 pubmed publisher
    Pharmacological manipulations of constitutive nitric oxide (cNO) levels have been shown to have variable effects on Na absorption in vivo and in vitro in different tissues. Species differences, untoward in vivo effects (e.g...
  41. Betz M, Brooks Russell A, Brandspigel S, Novins D, Tung G, Runyan C. Counseling Suicidal Patients About Access to Lethal Means: Attitudes of Emergency Nurse Leaders. J Emerg Nurs. 2018;44:499-504 pubmed publisher
    ..We invited a nurse leader (ED nurse manager or Chief Nursing Officer [CNO]) at each hospital-based emergency department in the 8-state Mountain West region of the United States to complete ..
  42. Zou D, Chen L, Deng D, Jiang D, Dong F, McSweeney C, et al. DREADD in parvalbumin interneurons of the dentate gyrus modulates anxiety, social interaction and memory extinction. Curr Mol Med. 2016;16:91-102 pubmed
    ..of the hM3D-Gq-mCherry vector with a Cre plasmid resulted in a cellular response to hM3Dq ligand clozapine-N-oxide (CNO) stimulation...
  43. Pina M, Cunningham C. Ethanol-seeking behavior is expressed directly through an extended amygdala to midbrain neural circuit. Neurobiol Learn Mem. 2017;137:83-91 pubmed publisher
    ..Before testing the expression of preference, clozapine-N-oxide (CNO) was peripherally administered to activate hM4Di receptors and selectively inhibit these cells...
  44. Ingwell Spolan C. Chief Nursing Officers' Views on Meeting the Needs of the Professional Nurse: How This Can Affect Patient Outcomes. Healthcare (Basel). 2018;6: pubmed publisher
    ..The purpose of this study was to understand the CNO's view of meeting the needs of the Registered Nurse (RN) at point of care and how this could affect quality patient ..
  45. Owoyele B, Ayilara O. Coconut oil protects against light-induced retina degeneration in male Wistar rats. Pathophysiology. 2019;26:89-95 pubmed publisher
    The retinoprotective effect of Cocos nucifera oil (CNO) was investigated. Twenty male Wistar rats weighing 140 g and 180 g were randomly divided into four groups comprising of five animals each...
  46. Padwa B, Dentino K, Robson C, Woo S, Kurek K, Resnick C. Pediatric Chronic Nonbacterial Osteomyelitis of the Jaw: Clinical, Radiographic, and Histopathologic Features. J Oral Maxillofac Surg. 2016;74:2393-2402 pubmed publisher
    Chronic nonbacterial osteomyelitis (CNO) is a focal sterile inflammatory osteitis in children that most commonly develops in the long bones, but can occur in any bone...
  47. Zhao Y, Chauvin N, Jaramillo D, Burnham J. Aggressive Therapy Reduces Disease Activity without Skeletal Damage Progression in Chronic Nonbacterial Osteomyelitis. J Rheumatol. 2015;42:1245-51 pubmed publisher
    ..assess changes in disease activity and skeletal damage in children with chronic nonbacterial osteomyelitis (CNO) after infliximab and methotrexate, with or without zoledronic acid or nonsteroidal antiinflammatory drug (NSAID) ..
  48. Pham L, Luu B, Phuoc H, Le H, Truong H, Luu P, et al. Production of Biodiesel from Candlenut Oil Using a Two-step Co-solvent Method and Evaluation of Its Gaseous Emissions. J Oleo Sci. 2018;67:617-626 pubmed publisher
    Candlenut oil (CNO) is a potentially new feedstock for biodiesel (BDF) production. In this paper, a two-step co-solvent method for BDF production from CNO was examined...
  49. Gill A, Bogorodsky S, Mal A. Acanthoplesiops cappuccino, a new species of acanthoclinine fish from the Red Sea (Teleostei: Plesiopidae) . Zootaxa. 2013;3750:216-22 pubmed publisher
  50. Taddio A, Zennaro F, Pastore S, Cimaz R. An Update on the Pathogenesis and Treatment of Chronic Recurrent Multifocal Osteomyelitis in Children. Paediatr Drugs. 2017;19:165-172 pubmed publisher
    Chronic recurrent multifocal osteomyelitis (CRMO), also known as chronic non-bacterial osteomyelitis (CNO), is a rare inflammatory disorder that primarily affects children...
  51. Yoo H, Roth Johnson E, Bor B, Quinlan M. Drosophila Cappuccino alleles provide insight into formin mechanism and role in oogenesis. Mol Biol Cell. 2015;26:1875-86 pubmed publisher
    ..Together our results on the loop and the seven missense mutations provides mechanistic insight into formin function in general and Capu's role in the Drosophila oocyte in particular. ..
  52. Panoz Brown D, Iyer V, Carey L, Sluka C, Rajic G, Kestenman J, et al. Replay of Episodic Memories in the Rat. Curr Biol. 2018;28:1628-1634.e7 pubmed publisher
    ..The chemogenetic activating drug clozapine N-oxide (CNO), but not vehicle, reversibly impairs episodic memory replay in rats previously injected bilaterally in the ..
  53. Nishimura Y, Moriyama M, Kawabe K, Satoh H, Takano K, Azuma Y, et al. Lauric Acid Alleviates Neuroinflammatory Responses by Activated Microglia: Involvement of the GPR40-Dependent Pathway. Neurochem Res. 2018;43:1723-1735 pubmed publisher
    ..Mounting evidence indicates that dietary supplementation with coconut oil (CNO) reduces the cognitive deficits associated with AD; however, the precise mechanism(s) underlying the beneficial ..
  54. Upright N, Brookshire S, Schnebelen W, Damatac C, Hof P, Browning P, et al. Behavioral Effect of Chemogenetic Inhibition Is Directly Related to Receptor Transduction Levels in Rhesus Monkeys. J Neurosci. 2018;38:7969-7975 pubmed publisher
    ..response task to assess working memory function after intramuscular injection of either clozapine-N-oxide (CNO) or vehicle. CNO injections given before DREADD transduction were without effect on behavior...
  55. Chai X, Meng Z, Jiang J, Cao P, Liang X, Piatko M, et al. Non-triglyceride components modulate the fat crystal network of palm kernel oil and coconut oil. Food Res Int. 2018;105:423-431 pubmed publisher
    PKO and CNO are composed of 97-98% triacylglycerols and 2-3% minor non-triglyceride components (FFA, DAG and MAG). Triglycerides were separated from minor components by chromatographic method...
  56. Brandt D, Sohr E, Pablik J, Schnabel A, Kapplusch F, Mäbert K, et al. CD14+ monocytes contribute to inflammation in chronic nonbacterial osteomyelitis (CNO) through increased NLRP3 inflammasome expression. Clin Immunol. 2018;196:77-84 pubmed publisher
    The pathophysiology of chronic nonbacterial osteomyelitis (CNO) remains incompletely understood. Increased NLRP3 inflammasome activation and IL-1β release in monocytes from CNO patients was suggested to contribute to bone inflammation...
  57. Hennessy M, Corcoran A, Brust R, Chang Y, Nattie E, Dymecki S. Activity of Tachykinin1-Expressing Pet1 Raphe Neurons Modulates the Respiratory Chemoreflex. J Neurosci. 2017;37:1807-1819 pubmed publisher
    ..Chemogenetic [clozapine-N-oxide (CNO)-hM4Di] perturbation of Tac1-Pet1 neuron activity blunted the ventilatory response of the respiratory CO..
  58. Nidhi B, Ramaprasad T, Baskaran V. Dietary fatty acid determines the intestinal absorption of lutein in lutein deficient mice. Food Res Int. 2014;64:256-263 pubmed publisher
    The present investigation was undertaken to study the influence of dietary lipids [olive (OO), coconut (CNO), groundnut (GNO), soybean (SBO), sunflower (SFO), rice bran (RBO), corn (CO), palm (PO), fish (FO) oils] on the bioavailability ..
  59. Ferguson P, Laxer R. New discoveries in CRMO: IL-1β, the neutrophil, and the microbiome implicated in disease pathogenesis in Pstpip2-deficient mice. Semin Immunopathol. 2015;37:407-12 pubmed publisher
    Chronic non-bacterial osteomyelitis (CNO), chronic recurrent multifocal osteomyelitis (CRMO) and synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome are autoinflammatory disorder(s) in which sterile osteomyelitis is ..
  60. Hetmann A, Wujak M, Bolibok P, Zięba W, Wisniewski M, Roszek K. Novel biocatalytic systems for maintaining the nucleotide balance based on adenylate kinase immobilized on carbon nanostructures. Mater Sci Eng C Mater Biol Appl. 2018;88:130-139 pubmed publisher
    In this study graphene oxide (GO), carbon quantum dots (CQD) and carbon nanoonions (CNO) have been characterized and applied for the first time as a matrix for recombinant adenylate kinase (AK, EC immobilization...
  61. Mahoney C, Agostinelli L, Brooks J, Lowell B, Scammell T. GABAergic Neurons of the Central Amygdala Promote Cataplexy. J Neurosci. 2017;37:3995-4006 pubmed publisher
    ..sleep/wake behavior and cataplexy after injection of saline or the hM3/hM4 ligand clozapine-N-oxide (CNO) under baseline conditions and under conditions that should elicit positive emotions...
  62. Koga K, Kanehisa K, Kohro Y, Shiratori Hayashi M, Tozaki Saitoh H, Inoue K, et al. Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours. Sci Rep. 2017;7:4739 pubmed publisher
    ..We found that clozapine-N-oxide (CNO) treatment rapidly hyperpolarized these neurons and induced spontaneous nocifensive behaviours in these mice...
  63. Moghabghab R, Hamilton Jones M, Jabbour R, McNabb A, Tilley E. Nurse Practitioner Practice and Controlled Substances in Ontario: Current Practice and Future Intent. Nurs Leadersh (Tor Ont). 2016;29:93-105 pubmed
    ..In 2013, the College of Nurses of Ontario (CNO) conducted an online survey of NPs to inform future development of regulations and practice standards that would ..
  64. Schnabel A, Range U, Hahn G, Berner R, Hedrich C. Treatment Response and Longterm Outcomes in Children with Chronic Nonbacterial Osteomyelitis. J Rheumatol. 2017;44:1058-1065 pubmed publisher
    The autoinflammatory bone disorder chronic nonbacterial osteomyelitis (CNO) covers a wide clinical spectrum, ranging from mild self-limited presentations to chronically active or recurrent courses, which are then referred to as chronic ..
  65. Sun J, Ray R. Tg(Th-Cre)FI172Gsat (Th-Cre) defines neurons that are required for full hypercapnic and hypoxic reflexes. Biol Open. 2017;6:1200-1208 pubmed publisher
    ..We report that clozapine-N-oxide (CNO)-DREADD-mediated inhibition of Th-Cre-defined neurons results in blunted ventilatory responses under ..
  66. Pan X, Uno I, Wang Z, Yamamoto S, Hara Y, Wang Z. Seasonal variabilities in chemical compounds and acidity of aerosol particles at urban site in the west Pacific. Environ Pollut. 2018;237:868-877 pubmed publisher
    ..Nitrate in PM2.5-10 (cNO3) increased during long-range transport of dust, implying the great importance of heterogeneous ..
  67. Milosavljevic N, Allen A, Cehajic Kapetanovic J, Lucas R. Chemogenetic Activation of ipRGCs Drives Changes in Dark-Adapted (Scotopic) Electroretinogram. Invest Ophthalmol Vis Sci. 2016;57:6305-6312 pubmed publisher
    ..Intraperitoneal injection of clozapine N-oxide (CNO) at 5 mg/kg was used for acute activation of hM3Dq and thus excitation of ipRGCs in darkness...
  68. Grace P, Wang X, Strand K, Baratta M, Zhang Y, Galer E, et al. DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats. Exp Neurol. 2018;304:125-131 pubmed publisher
    ..significant allodynia following intrathecal administration of the DREADD-selective ligand clozapine-N-oxide (CNO), which was abolished by intrathecal interleukin-1 receptor antagonist...
  69. Schnabel A, Range U, Hahn G, Siepmann T, Berner R, Hedrich C. Unexpectedly high incidences of chronic non-bacterial as compared to bacterial osteomyelitis in children. Rheumatol Int. 2016;36:1737-1745 pubmed
    ..This study was to compare characteristics of children with chronic non-bacterial (CNO) and bacterial osteomyelitis (BOM)...
  70. Bunney P, Zink A, Holm A, Billington C, Kotz C. Orexin activation counteracts decreases in nonexercise activity thermogenesis (NEAT) caused by high-fat diet. Physiol Behav. 2017;176:139-148 pubmed publisher
    ..Then, among animals on HFD, orexin neurons were activated following injections of clozapine n-oxide (CNO). Mice on HFD spent significantly less time eating (p<0...
  71. Ghani S, Barzegar H, Noshad M, Hojjati M. The preparation, characterization and in vitro application evaluation of soluble soybean polysaccharide films incorporated with cinnamon essential oil nanoemulsions. Int J Biol Macromol. 2018;112:197-202 pubmed publisher
    ..soybean polysaccharide (SSPS) incorporated with different concentrations of cinnamon essential oil nanoemulsions (CNO) and the functional properties of them were evaluated...
  72. Padovan Hernandez Y, Knackstedt L. Dose-dependent reduction in cocaine-induced locomotion by Clozapine-N-Oxide in rats with a history of cocaine self-administration. Neurosci Lett. 2018;674:132-135 pubmed publisher
    ..Designer receptors based on the muscarinic M3 and M4 subtypes were designed to be activated by clozapine-N-oxide (CNO), a ligand previously shown to be an inert metabolite of clozapine...
  73. Ramoneda Paniagua A, van der Haar R. [Update the wood dust exposure values included in the job-exposure matrix MatEmESp by making use of the WOODEX database]. Arch Prev Riesgos Labor. 2016;19:22-9 pubmed publisher
    ..The occupations with the highest prevalence values are sawmill operators (CNO-94 code 8141) and operators of machinery for making wood products (CNO-94 code 8340)...
  74. García Gómez M. [Occupational diseases of musicians: the price of perfection]. Arch Prev Riesgos Labor. 2018;21:11-17 pubmed publisher
    ..32 Composers, musicians and singers (CNO-2011) for the period 2007 to 2014...
  75. Manvich D, Webster K, Foster S, Farrell M, Ritchie J, Porter J, et al. The DREADD agonist clozapine N-oxide (CNO) is reverse-metabolized to clozapine and produces clozapine-like interoceptive stimulus effects in rats and mice. Sci Rep. 2018;8:3840 pubmed publisher
    Clozapine-N-oxide (CNO) has long been the ligand of choice for selectively activating Designer Receptors Exclusively Activated by Designer Drugs (DREADDs)...
  76. Jiang L, Wu X, Wang S, Chen S, Zhou H, Wilson B, et al. Clozapine metabolites protect dopaminergic neurons through inhibition of microglial NADPH oxidase. J Neuroinflammation. 2016;13:110 pubmed publisher
    ..The purpose of this study was to explore the neuroprotective effects of clozapine metabolites clozapine N-oxide (CNO) and N-desmethylclozapine (NDC), as well as their propensity to cause neutropenia...
  77. Ma S, Allocca G, Ong Pålsson E, Singleton C, Hawkes D, McDougall S, et al. Nucleus incertus promotes cortical desynchronization and behavioral arousal. Brain Struct Funct. 2017;222:515-537 pubmed publisher
    ..We used a chemogenetic approach-clozapine-N-oxide (CNO) activation of virally delivered excitatory hM3Dq-DREADDs-to activate the NI in rats and examined the behavioral ..
  78. Tan T, Luo Y, Zhong C, Xu X, Feng Y. Comprehensive profiling and characterization of coumarins from roots, stems, leaves, branches, and seeds of Chimonanthus nitensOliv. using ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry combined with modified mass. J Pharm Biomed Anal. 2017;141:140-148 pubmed publisher
    Chimonanthus nitensOliv. (CNO), having been studied and developed as the tea beverages, tea raw materials and preparations, an unique species in China, have been extensively used for treating colds and influenza for centuries...
  79. Bocchialini G, Ferrari L, Rossini M, Bozzola A, Burlini D. Chronic nonbacterial osteomyelitis involving the mandible: A case report. Int J Surg Case Rep. 2017;37:149-153 pubmed publisher
    Chronic nonbacterial osteomyelitis (CNO) or chronic recurrent multifocal osteomyelitis (CRMO), is a very rare condition of unknown aetiology...
  80. Chang S, Todd T, Bucci D, Smith K. Chemogenetic manipulation of ventral pallidal neurons impairs acquisition of sign-tracking in rats. Eur J Neurosci. 2015;42:3105-16 pubmed publisher
    ..of VP neurons [activation of the inhibitory hM4D(Gi) DREADD through systemic injections of clozapine N-oxide (CNO) prior to each autoshaping session] impaired acquisition of sign-tracking (lever press rate) without having any ..
  81. Wicker E, Forcelli P. Chemogenetic silencing of the midline and intralaminar thalamus blocks amygdala-kindled seizures. Exp Neurol. 2016;283:404-12 pubmed publisher
    ..When treated with the otherwise inert ligand Clozapine-N-Oxide (CNO) at doses of 2...
  82. MacLaren D, Browne R, Shaw J, Krishnan Radhakrishnan S, Khare P, Espana R, et al. Clozapine N-Oxide Administration Produces Behavioral Effects in Long-Evans Rats: Implications for Designing DREADD Experiments. Eneuro. 2016;3: pubmed
    Clozapine N-oxide (CNO) is a ligand for a powerful chemogenetic system that can selectively inhibit or activate neurons; the so-called Designer Receptors Exclusively Activated by Designer Drugs (DREADD) system...
  83. Ji B, Kaneko H, Minamimoto T, Inoue H, Takeuchi H, Kumata K, et al. Multimodal Imaging for DREADD-Expressing Neurons in Living Brain and Their Application to Implantation of iPSC-Derived Neural Progenitors. J Neurosci. 2016;36:11544-11558 pubmed
    ..receptor exclusively activated by designer drugs, DREADD) that is activated exclusively by clozapine-N-oxide (CNO)...
  84. Hofmann S, Kapplusch F, Mäbert K, Hedrich C. The molecular pathophysiology of chronic non-bacterial osteomyelitis (CNO)-a systematic review. Mol Cell Pediatr. 2017;4:7 pubmed publisher
    Chronic non-bacterial osteomyelitis (CNO) belongs to the growing spectrum of autoinflammatory diseases and primarily affects the skeletal system. Peak onset ranges between 7 and 12 years of age...
  85. Taddio A, Ferrara G, Insalaco A, Pardeo M, Gregori M, Finetti M, et al. Dealing with Chronic Non-Bacterial Osteomyelitis: a practical approach. Pediatr Rheumatol Online J. 2017;15:87 pubmed publisher
    Chronic Non-Bacterial Osteomyelitis (CNO) is an inflammatory disorder that primarily affects children. Although underestimated, its incidence is rare. For these reasons, no diagnostic and no therapeutic guidelines exist...
  86. Sengupta A, Winters B, Bagley E, McNally G. Disrupted Prediction Error Links Excessive Amygdala Activation to Excessive Fear. J Neurosci. 2016;36:385-95 pubmed publisher
    ..We expressed the excitatory hM3Dq DREADD in rat BLA glutamatergic neurons and showed that CNO acted selectively to increase their activity, depolarizing these neurons and increasing their firing rates...
  87. Saloman J, Scheff N, Snyder L, Ross S, Davis B, Gold M. Gi-DREADD Expression in Peripheral Nerves Produces Ligand-Dependent Analgesia, as well as Ligand-Independent Functional Changes in Sensory Neurons. J Neurosci. 2016;36:10769-10781 pubmed
    ..baseline heat thresholds in both male and female mice expressing Gi-DREADD were normal, 1 mg/kg clozapine-N-oxide (CNO) produced a significant 3 h increase in heat threshold that returned to baseline by 5 h after injection...
  88. Wang T, He X, Huang T, Li C, Zhang W. Collective neurodynamic optimization for economic emission dispatch problem considering valve point effect in microgrid. Neural Netw. 2017;93:126-136 pubmed publisher
    ..It has multiple constraints and nonconvex objectives. To solve it, the collective neurodynamic optimization (CNO) method, which combines heuristic approach and projection neural network (PNN), is attempted to optimize scheduling ..
  89. Pardeo M, Pires Marafon D, Messia V, Garganese M, De Benedetti F, Insalaco A. Anakinra in a Cohort of Children with Chronic Nonbacterial Osteomyelitis. J Rheumatol. 2017;44:1231-1238 pubmed publisher
    To report efficacy and safety in patients with chronic nonbacterial osteomyelitis (CNO) unresponsive to nonsteroidal antiinflammatory drugs (NSAID) and bisphosphonates and/or glucocorticoids treated with anakinra...
  90. Mykhailiv O, Lapiński A, Molina Ontoria A, Regulska E, Echegoyen L, Dubis A, et al. Influence of the Synthetic Conditions on the Structural and Electrochemical Properties of Carbon Nano-Onions. Chemphyschem. 2015;16:2182-91 pubmed publisher
    ..The resulting spherical CNO structures were thermally modified under different atmospheres and characterized by SEM, TEM, thermogravimetric ..
  91. Pienaar I, Gartside S, Sharma P, de Paola V, Gretenkord S, Withers D, et al. Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson's disease. Mol Neurodegener. 2015;10:47 pubmed publisher the lactacystin rat model of PD, via peripheral administration of the cognate DREADD ligand, clozapine-N-oxide (CNO), dramatically improved motor symptoms, as was assessed by behavioral tests that measured postural instability, ..
  92. Liu Y, Huang Y, Liu T, Wu H, Cui H, Gautron L. Lipopolysacharide Rapidly and Completely Suppresses AgRP Neuron-Mediated Food Intake in Male Mice. Endocrinology. 2016;157:2380-92 pubmed publisher
    ..the designer receptor hM3Dq-Gq only in AgRP neurons, the administration of the designer drug clozapine-N-oxide (CNO) induced robust food intake...