BIRC7

Summary

Gene Symbol: BIRC7
Description: baculoviral IAP repeat containing 7
Alias: KIAP, LIVIN, ML-IAP, MLIAP, RNF50, baculoviral IAP repeat-containing protein 7, RING finger protein 50, RING-type E3 ubiquitin transferase BIRC7, kidney inhibitor of apoptosis protein, livin inhibitor of apoptosis, melanoma inhibitor of apoptosis protein
Species: human
Products:     BIRC7

Top Publications

  1. Kasof G, Gomes B. Livin, a novel inhibitor of apoptosis protein family member. J Biol Chem. 2001;276:3238-46 pubmed
    A novel human inhibitor of apoptosis protein (IAP) family member termed Livin was identified, containing a single baculoviral IAP repeat (BIR) domain and a COOH-terminal RING finger domain...
  2. Vucic D, Deshayes K, Ackerly H, Pisabarro M, Kadkhodayan S, Fairbrother W, et al. SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP). J Biol Chem. 2002;277:12275-9 pubmed
    ..These results demonstrate the feasibility of using SMAC peptides as a way to sensitize IAP-expressing cells to pro-apoptotic stimuli such as chemotherapeutic agents. ..
  3. Sanna M, da Silva Correia J, Ducrey O, Lee J, Nomoto K, Schrantz N, et al. IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition. Mol Cell Biol. 2002;22:1754-66 pubmed
    ..These data suggest that XIAP's antiapoptotic activity is achieved by two separate mechanisms: one requiring TAK1-dependent JNK1 activation and the second involving caspase inhibition. ..
  4. Crnkovic Mertens I, Semzow J, Hoppe Seyler F, Butz K. Isoform-specific silencing of the Livin gene by RNA interference defines Livin beta as key mediator of apoptosis inhibition in HeLa cells. J Mol Med (Berl). 2006;84:232-40 pubmed
    b>Livin (alternatively called ML-IAP or KIAP) is a cancer-associated member of the antiapoptotic inhibitor of apoptosis protein family. Two splicing variants of Livin, designated Livin alpha and Livin beta, have been identified...
  5. Ashhab Y, Alian A, Polliack A, Panet A, Ben Yehuda D. Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern. FEBS Lett. 2001;495:56-60 pubmed
    ..We refer here to the longer and shorter variants as Livin alpha and beta, respectively...
  6. Abd Elrahman I, Hershko K, Neuman T, Nachmias B, Perlman R, Ben Yehuda D. The inhibitor of apoptosis protein Livin (ML-IAP) plays a dual role in tumorigenicity. Cancer Res. 2009;69:5475-80 pubmed publisher
    ..We and others previously described the IAP Livin (ML-IAP)...
  7. Yan B, Kong M, Chen S, Chen Y. VEGF stimulation enhances Livin protein synthesis through mTOR signaling. J Cell Biochem. 2010;111:1114-24 pubmed publisher
    b>Livin is a member of inhibitors of apoptosis proteins (IAPs) and overexpressed in transformed cells and several cancers...
  8. Kempkensteffen C, Hinz S, Christoph F, Krause H, Koellermann J, Magheli A, et al. Expression of the apoptosis inhibitor livin in renal cell carcinomas: correlations with pathology and outcome. Tumour Biol. 2007;28:132-8 pubmed
    b>Livin has recently been identified as a member of the inhibitor of apoptosis family expressed in several types of cancer but not in most benign tissues...
  9. Wagener N, Crnkovic Mertens I, Vetter C, Macher Göppinger S, Bedke J, Gröne E, et al. Expression of inhibitor of apoptosis protein Livin in renal cell carcinoma and non-tumorous adult kidney. Br J Cancer. 2007;97:1271-6 pubmed
    The antiapoptotic Livin/ML-IAP gene has recently gained much attention as a potential new target for cancer therapy...

More Information

Publications105 found, 100 shown here

  1. Wang L, Zhang Q, Liu B, Han M, Shan B. Challenge and promise: roles for Livin in progression and therapy of cancer. Mol Cancer Ther. 2008;7:3661-9 pubmed publisher
    b>Livin is a member of the inhibitors of apoptosis protein gene family, which is highly expressed in a variety of human neoplasms...
  2. Choi J, Hwang Y, Sung K, Lee S, Yoo K, Jung H, et al. Expression of Livin, an antiapoptotic protein, is an independent favorable prognostic factor in childhood acute lymphoblastic leukemia. Blood. 2007;109:471-7 pubmed
    b>Livin, a member of the inhibitor of apoptosis proteins, has been considered to be a poor prognostic marker in malignancies...
  3. Augello C, Caruso L, Maggioni M, Donadon M, Montorsi M, Santambrogio R, et al. Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma. BMC Cancer. 2009;9:125 pubmed publisher
    ..The overall survival analysis was estimated according to the Kaplan-Meier method. Survivin and Livin/ML-IAP mRNAs were significantly over-expressed in cancer tissues compared to non-neoplastic counterparts...
  4. Ye L, Song X, Li S, Yang D, Zhang J, Che X, et al. Livin-? promotes cell proliferation by regulating G1-S cell cycle transition in prostate cancer. Prostate. 2011;71:42-51 pubmed publisher
    Prostate cancer is the third most common cancer and the second leading cause of cancer death for males in US. Livin has recently been described as a cancer-associated member of inhibitor of apoptosis proteins family, highly expressed in ..
  5. Vucic D, Stennicke H, Pisabarro M, Salvesen G, Dixit V. ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. Curr Biol. 2000;10:1359-66 pubmed
    ..Elevated expression of ML-IAP renders melanoma cells resistant to apoptotic stimuli and thereby potentially contributes to the pathogenesis of this malignancy. ..
  6. Crnkovic Mertens I, Hoppe Seyler F, Butz K. Induction of apoptosis in tumor cells by siRNA-mediated silencing of the livin/ML-IAP/KIAP gene. Oncogene. 2003;22:8330-6 pubmed
    ..As a molecular target, we chose the antiapoptotic livin (ML-IAP, KIAP) gene, which is expressed in a subset of human tumors...
  7. Crnkovic Mertens I, Wagener N, Semzow J, Gröne E, Haferkamp A, Hohenfellner M, et al. Targeted inhibition of Livin resensitizes renal cancer cells towards apoptosis. Cell Mol Life Sci. 2007;64:1137-44 pubmed
    ..In order to investigate a possible role for the anti-apoptotic livin gene in renal cell cancer (RCC), we analyzed its expression in tumor tissue samples and in RCC-derived cell lines...
  8. Yan B. Research progress on Livin protein: an inhibitor of apoptosis. Mol Cell Biochem. 2011;357:39-45 pubmed publisher
    b>Livin is a member of the inhibitors of apoptosis (IAP) family, which plays crucial roles in apoptosis, cell proliferation, and cell cycle control...
  9. Lin J, Deng G, Huang Q, Morser J. KIAP, a novel member of the inhibitor of apoptosis protein family. Biochem Biophys Res Commun. 2000;279:820-31 pubmed
    We have identified a novel human gene, kiap (kidney inhibitor of apoptosis protein) that encodes a single BIR domain and a RING zinc finger domain. kiap has been assigned to the q13...
  10. Andersen M, Reker S, Becker J, thor Straten P. The melanoma inhibitor of apoptosis protein: a target for spontaneous cytotoxic T cell responses. J Invest Dermatol. 2004;122:392-9 pubmed
    ..The melanoma inhibitor of apoptosis protein, ML-IAP (also named livin) counteracts apoptosis induced by death receptors, hypooxgenic ..
  11. Crnkovic Mertens I, Muley T, Meister M, Hartenstein B, Semzow J, Butz K, et al. The anti-apoptotic livin gene is an important determinant for the apoptotic resistance of non-small cell lung cancer cells. Lung Cancer. 2006;54:135-42 pubmed
    Cancer cells are typically characterized by increased resistance towards apoptosis. Livin (alternatively called ML-IAP or KIAP) is an anti-apoptotic protein which is expressed in several cancer forms...
  12. Gazzaniga P, Gradilone A, Giuliani L, Gandini O, Silvestri I, Nofroni I, et al. Expression and prognostic significance of LIVIN, SURVIVIN and other apoptosis-related genes in the progression of superficial bladder cancer. Ann Oncol. 2003;14:85-90 pubmed
    ..Recently LIVIN, belonging to the inhibitors of apoptosis (IAP) family, has been found to be expressed in most solid tumors, where ..
  13. Tanabe H, Yagihashi A, Tsuji N, Shijubo Y, Abe S, Watanabe N. Expression of survivin mRNA and livin mRNA in non-small-cell lung cancer. Lung Cancer. 2004;46:299-304 pubmed
    ..Anti-apoptotic survivin and livin genes are highly expressed in cancer cells and transformed cells, but show little or no expression in normal ..
  14. Yagihashi A, Ohmura T, Asanuma K, Kobayashi D, Tsuji N, Torigoe T, et al. Detection of autoantibodies to survivin and livin in sera from patients with breast cancer. Clin Chim Acta. 2005;362:125-30 pubmed
    Survivin and livin are highly expressed in cancer cells and transformed cells, but show little or no expression in normal differentiated tissues...
  15. Nachmias B, Lazar I, Elmalech M, Abed El Rahaman I, Asshab Y, Mandelboim O, et al. Subcellular localization determines the delicate balance between the anti- and pro-apoptotic activity of Livin. Apoptosis. 2007;12:1129-42 pubmed
    b>Livin is a member of the Inhibitor of Apoptosis Protein family which inhibits apoptosis induced by a variety of stimuli...
  16. Dynek J, Chan S, Liu J, Zha J, Fairbrother W, Vucic D. Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas. Cancer Res. 2008;68:3124-32 pubmed publisher
    ..Collectively, these findings implicate MITF as a major transcriptional regulator of ML-IAP expression in melanomas, and suggest that ML-IAP contributes to the prosurvival activity of MITF in melanoma progression. ..
  17. Chen Y, Li H, Lin M, Chen G, Xie B, Xu N, et al. Livin abrogates apoptosis of SPC-A1 cell by regulating JNKI signaling pathway. Mol Biol Rep. 2010;37:2241-7 pubmed publisher
    b>Livin, a novel member of inhibitors of apoptosis protein, is highly expressed in tumor tissues. It is a potential target in tumor therapy...
  18. Xue D, Zuo K, Li X, Zhang T, Chen H, Cheng Y, et al. Expression and prognostic significance of livin, caspase-3, and ki-67 in the progression of human ampullary carcinoma. Appl Immunohistochem Mol Morphol. 2013;21:525-31 pubmed publisher
    b>Livin is a new member of the inhibitor of apoptosis proteins family of proteins that interacts with downstream caspases, such as caspase-3, caspase-7, and caspase-9, however, its role in human ampullary carcinoma has not been clearly ..
  19. Lin H, Lin D, Xiong X. Differential expression of Livin, caspase-3, and second mitochondria-derived activator of caspases in chronic rhinosinusitis with nasal polyps. Otolaryngol Head Neck Surg. 2014;151:1067-72 pubmed publisher
    The pathogenesis of human chronic rhinosinusitis with nasal polyps (CRSwNP) remains undetermined. Livin is a member of the inhibitor of the apoptosis protein family proteins...
  20. Dubil E, Tian C, Wang G, Tarney C, Bateman N, Levine D, et al. Racial disparities in molecular subtypes of endometrial cancer. Gynecol Oncol. 2018;149:106-116 pubmed publisher
    ..024) and exhibited race-associated enrichment in cell cycle signaling and pathways in cancer including PLK1 and BIRC7. All of these aggressive molecular subtypes also indicated worse PFS in White patients, with unique enrichments in ..
  21. Nachmias B, Mizrahi S, Elmalech M, Lazar I, Ashhab Y, Gazit R, et al. Manipulation of NK cytotoxicity by the IAP family member Livin. Eur J Immunol. 2007;37:3467-76 pubmed
    ..We have previously described a new IAP family member, termed Livin, which has two splice variants (alpha and beta) with differential anti-apoptotic activities...
  22. Dou H, Buetow L, Sibbet G, Cameron K, Huang D. BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer. Nat Struct Mol Biol. 2012;19:876-83 pubmed publisher
    ..Here we report the structure of the human dimeric RING domain from BIRC7 in complex with the E2 UbcH5B covalently linked to Ub (UbcH5B?Ub)...
  23. Zoellner J, You W, Almeida F, Blackman K, Harden S, Glasgow R, et al. The Influence of Health Literacy on Reach, Retention, and Success in a Worksite Weight Loss Program. Am J Health Promot. 2016;30:279-82 pubmed publisher
    ..activity behaviors: incentaHEALTH (INCENT; incentivized individually targeted Internet-based intervention) and Livin' My Weigh (LMW; less-intense quarterly newsletters)...
  24. Gelaleti G, Borin T, Maschio Signorini L, Moschetta M, Jardim Perassi B, Calvinho G, et al. Efficacy of melatonin, IL-25 and siIL-17B in tumorigenesis-associated properties of breast cancer cell lines. Life Sci. 2017;183:98-109 pubmed publisher
    ..of apoptosis pathway proteins showed an increase of CYTO-C, DR6, IGFBP-3, IGFBP-5, IGFPB-6, IGF-1, IGF-1R, Livin, P21, P53, TNFRII, XIAP and hTRA proteins and reduction of caspase-3 (p<0.05) after melatonin treatment...
  25. Liu X, Wang A, Gao H, Yuan Z, Jiao Y. Expression and role of the inhibitor of apoptosis protein livin in chemotherapy sensitivity of ovarian carcinoma. Int J Oncol. 2012;41:1021-8 pubmed publisher
    Ovarian cancer has the highest mortality rate of all gynecological malignancies. Livin, a novel member of the inhibitor of apoptosis protein family, has been found to be expressed in various malignancies and is suggested to have poor ..
  26. Xu M, Xia L, Fan L, Xue J, Shao W, Xu D. Livin and caspase-3 expression are negatively correlated in cervical squamous cell cancer. Eur J Gynaecol Oncol. 2013;34:152-5 pubmed
    Overexpression in cancer cells of inhibitor of apoptosis proteins like livin appears to promote tumorigenesis by regulating expression of proteins involved in apoptosis signaling...
  27. Tchoghandjian A, Soubéran A, Tabouret E, Colin C, Denicolaï E, Jiguet Jiglaire C, et al. Inhibitor of apoptosis protein expression in glioblastomas and their in vitro and in vivo targeting by SMAC mimetic GDC-0152. Cell Death Dis. 2016;7:e2325 pubmed publisher
    ..This study revealed for the first time that ML-IAP protein expression correlates with GBM patient survival and that its antagonist GDC-0152 improves outcome in xenografted mouse. ..
  28. Zhuo X, Zhao H, Jiang Z, Chen Q, Chang A. [Expression of Livin in laryngeal squamous cell carcinoma and relationship with bFGF]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008;22:114-6 pubmed
    To detect the roles of Livin and its relationship with bFGF in laryngeal squamous cell carcinoma (LSCC) through observing the expression of Livin and bFGF in laryngeal squamous cell carcinoma...
  29. Du Y, Zhu M, Zhou X, Huang Z, Zhu J, Xu J, et al. miR-20a enhances cisplatin resistance of human gastric cancer cell line by targeting NFKBIB. Tumour Biol. 2016;37:1261-9 pubmed publisher
    ..was concurrent with the downregulation of NFKBIB (also known as IκBβ) as well as upregulation of p65, livin, and survivin. The luciferase activity suggested that NFKBIB was the direct target gene of miR-20a...
  30. Wei H, Gao Z, Zheng L, Zhang C, Liu Z, Yang Y, et al. Protective Effects of Fucoidan on A?25-35 and d-Gal-Induced Neurotoxicity in PC12 Cells and d-Gal-Induced Cognitive Dysfunction in Mice. Mar Drugs. 2017;15: pubmed publisher
    ..cytosol and activation of caspases, and increase the expression of apoptosis inhibitor proteins (IAPs), including livin and X-linked IAP (XIAP) in PC12 cells damaged by A?25-35 and d-Gal-induction...
  31. Zhang Z, Peng L, Luo Y, Zhou C. Prospective experimental studies on the renal protective effect of ulinastatin after paraquat poisoning. World J Emerg Med. 2012;3:299-304 pubmed publisher
    ..In this study, we observed the expression of caspase-3 and livin protein in rat renal tissue after PQ poisoning as well as the therapeutic effects of ulinastatin...
  32. Shiozaki E, Chai J, Rigotti D, Riedl S, Li P, Srinivasula S, et al. Mechanism of XIAP-mediated inhibition of caspase-9. Mol Cell. 2003;11:519-27 pubmed
    ..Thus, XIAP sequesters caspase-9 in a monomeric state, which serves to prevent catalytic activity. These studies, in conjunction with other observations, define a unified mechanism for the activation of all caspases. ..
  33. Durinck S, Stawiski E, Pavía Jiménez A, Modrusan Z, Kapur P, Jaiswal B, et al. Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes. Nat Genet. 2015;47:13-21 pubmed publisher
    ..Finally, we observed upregulation of the anti-apoptotic factor BIRC7 in MiTF-high RCC tumors, suggesting a potential therapeutic role for BIRC7 inhibitors.
  34. Xie J, Guo X, Liu F, Luo J, Duan F, Tao X. In vitro antitumor immune response induced by dendritic cells transduced with human livin α recombinant adenovirus. Cell Immunol. 2015;297:46-52 pubmed publisher
    ..b>Livin is a good candidate for cancer immunotherapy since it is overexpressed in most common human cancers, poorly ..
  35. Liu G, Wang W, Wang C, Li C, Zhang X, Li Q, et al. Livin modulates the apoptotic effects of vesicular stomatotitis virus in lung adenocarcinoma. Int J Oncol. 2015;47:1775-82 pubmed publisher
    ..In this study, we attempted to explore the expression of the anti-apoptotic factor Livin in lung adenocarcinoma and its possible relationship to VSV vulnerability...
  36. Zhu M, Zhou X, Du Y, Huang Z, Zhu J, Xu J, et al. miR-20a induces cisplatin resistance of a human gastric cancer cell line via targeting CYLD. Mol Med Rep. 2016;14:1742-50 pubmed publisher
    ..with miR?20a inhibitor increased the protein expression of CYLD, downregulated the expression levels of p65, livin and survivin, and led to a higher proportion of apoptotic cells in the SGC7901/DDP cells...
  37. Zhao Y, Deng X, Wang Q. [Expression and clinical significance of apoptosis associated genes Livin and Smac/DIABLO in human gastric carcinomas]. Ai Zheng. 2009;28:593-601 pubmed
    The proapoptotic gene Smac/DIABLO interacts with inhibitor of apoptosis protein Livin, which may contribute to regulating the impetus and progression of canceration...
  38. Wang T, Ding Q, Guo R, Shen H, Sun J, Lu K, et al. Expression of livin in gastric cancer and induction of apoptosis in SGC-7901 cells by shRNA-mediated silencing of livin gene. Biomed Pharmacother. 2010;64:333-8 pubmed publisher
    ..b>Livin, a novel inhibitor of apoptosis protein family, has been found to be expressed in various malignancies and is ..
  39. Ye L, Li S, Ye D, Yang D, Yue F, Guo Y, et al. Livin expression may be regulated by miR-198 in human prostate cancer cell lines. Eur J Cancer. 2013;49:734-40 pubmed publisher
    b>Livin has been recently described as an inhibitor of apoptosis, which is established to be associated with a variety of cancers. Metastatic prostate cancer cell line DU145 expresses high level of Livin mRNA yet low level of its protein...
  40. Liu A, He A, Tong W, Peng X, Tian Q, Wang H, et al. Prognostic significance of Livin expression in nasopharyngeal carcinoma after radiotherapy. Cancer Radiother. 2016;20:384-90 pubmed publisher
    This study was designed to investigate the expression levels of the inhibitor of apoptosis protein Livin in nasopharyngeal cancer tissues and its prognostic significance in nasopharyngeal carcinoma after radiotherapy...
  41. Nedelcu T, Kubista B, Koller A, Sulzbacher I, Mosberger I, Arrich F, et al. Livin and Bcl-2 expression in high-grade osteosarcoma. J Cancer Res Clin Oncol. 2008;134:237-44 pubmed
    ..The aim of this study was to determine if Livin and Bcl-2, acting as antiapoptotic proteins through different mechanisms, are expressed in osteosarcoma, and ..
  42. Yuan D, Liu L, Xu H, Gu D. The effects on cell growth and chemosensitivity by livin RNAi in non-small cell lung cancer. Mol Cell Biochem. 2009;320:133-40 pubmed publisher
    b>Livin is highly expressed in most tumor tissues and could inhibit the tumor cells apoptosis. Knockdown of endogenous livin expression in non-small cell lung cancer (NSCLC) cells could inhibit cell growth...
  43. Yang Y, Wang H, Wang J, Li X, Ma M, Yang W. [Effect of livin gene suppression by genistein on apoptosis, cell cycle and proliferation of malignant melanoma LiBr cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2012;32:1163-7 pubmed
    To observe the effect of livin gene suppression by genistein on apoptosis, cell cycle and proliferation of malignant melanoma LiBr cells...
  44. Zhao X, Yuan Y, Zhang Z, Feng X, Zhang J, Yuan X, et al. Effects of shRNA-silenced livin and survivin on lung cancer cell proliferation and apoptosis. J BUON. 2014;19:757-62 pubmed
    To evaluate the effects of short hairpin RNA (shRNA)-mediated silencing of livin and survivin on the proliferation and apoptosis of A549 lung cancer cells...
  45. Hsieh C, Lin Y, Wu C, Lee H, Shyu W, Wang C. Livin contributes to tumor hypoxia-induced resistance to cytotoxic therapies in glioblastoma multiforme. Clin Cancer Res. 2015;21:460-70 pubmed publisher
    ..b>Livin, a member of the family of inhibitor of apoptosis proteins, contributes antiapoptosis...
  46. Yin G, Li J, Zhang H. EXPRESSION AND CLINICAL SIGNIFICANCE OF APOPTOSIS-ASSOCIATED PROTEINS SURVIVIN AND LIVIN IN CONDYLOMA ACUMINATUM. J Biol Regul Homeost Agents. 2015;29:431-6 pubmed
    The objective of the present study was to explore the expression and significance of survivin and Livin in lesions of Condyloma acuminatum (CA)...
  47. Gu J, Ren L, Wang X, Qu C, Zhang Y. Expression of livin, survivin and caspase-3 in prostatic cancer and their clinical significance. Int J Clin Exp Pathol. 2015;8:14034-9 pubmed
    To explore the expressions level of Livin, Survivin and Caspase-3 in prostatic cancer and the relationship among the 3 proteins and the clinicopathological features as well as the correlation among them...
  48. Wang X, Sun H, Wang G, Fan Q. [Expression of anti-apoptosis livin gene in acute non-lymphocytic leukemia cells and its clinical significance]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008;16:35-7 pubmed
    To explore the expression of livin gene in acute non-lymphocytic leukemia (ANLL) cells and its clinical significance, the mRNA level of livin gene in 46 ANLL adult patients were measured by using reverse transcription polymerase chain ..
  49. Wu W, Duan Y, Lu G, Shi S, Zhang J, Wang H, et al. [Expression and significance of JNK1, Raf-1 and Livin in the carcinogenesis of sporadic colorectal tubular adenoma]. Zhonghua Zhong Liu Za Zhi. 2010;32:671-5 pubmed
    To study the possible role of JNK1, Raf-1 and Livin in the carcinogenesis of sporadic colorectal tubular adenoma...
  50. De Maria A, Bassnett S. Birc7: A Late Fiber Gene of the Crystalline Lens. Invest Ophthalmol Vis Sci. 2015;56:4823-34 pubmed publisher
    ..Expression of Livin, a member of the inhibitor of apoptosis protein (IAP) family encoded by Birc7, was strongly upregulated in deep cortical fiber cells...
  51. Wu D, Jiang Z, Gong B, Dou Y, Song M, Song X, et al. Vitamin E Reversed Apoptosis of Cardiomyocytes Induced by Exposure to High Dose Formaldehyde During Mice Pregnancy. Int Heart J. 2017;58:769-777 pubmed publisher
    ..5 mg/kg + 0.1 ?g Vit E). TUNEL staining was used to reveal the apoptosis in cardiomyocytes, and SOD, MDA, GSH, Livin, and Caspase-3 in cardiomyocytes were detected by ELISA, RT-PCR, and Western blot...
  52. Liu H, Kong C, Zeng Y, Liu X, Bi J, Jiang Y, et al. Livin may serve as a marker for prognosis of bladder cancer relapse and a target of bladder cancer treatment. Urol Oncol. 2009;27:277-83 pubmed publisher
    To evaluate the expression of Livin in bladder cancer, investigate its clinical and prognostic implications, and explore the effect of gene Livin transfection on the proliferation and apoptosis in bladder cancer cells...
  53. Dynek J, Goncharov T, Dueber E, Fedorova A, Izrael Tomasevic A, Phu L, et al. c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO J. 2010;29:4198-209 pubmed publisher
    ..Lastly, NF-?B essential modifier efficiently binds K11-linked ubiquitin chains, suggesting that this ubiquitin linkage may have a signalling role in the activation of proliferative cellular pathways. ..
  54. Lee D, Yoon T, Kim S, Park Y, Lee K, Lim S, et al. Relationship between expression of Livin and the biological behavior of human oral squamous cell carcinoma. Oncol Rep. 2014;32:2453-60 pubmed publisher
    b>Livin is one of the most important members of the inhibitor protein (IAP) family. It is overexpressed in several types of tumors and may have prognostic significance...
  55. Lv J, Qin Z, Zheng M, Chen Z, Wang Z. In vitro application of RNA interference to silence livin gene expression to induce apoptosis in leukemia cells. Eur Rev Med Pharmacol Sci. 2015;19:4390-6 pubmed
    ..To search for new targets and novel methods of anti-leukemia treatment and to discuss the mechanism of silencing the livin gene using small RNA interference technology to induce apoptosis in the K562 leukemia cell line...
  56. Ge Y, Cao X, Wang D, Sun W, Sun H, Han B, et al. Overexpression of Livin promotes migration and invasion of colorectal cancer cells by induction of epithelial-mesenchymal transition via NF-κB activation. Onco Targets Ther. 2016;9:1011-21 pubmed publisher
    b>Livin is a novel member of the inhibitors of apoptosis protein family and has been implicated in the development and progression of colorectal cancer (CRC). However, the underlying mechanisms of Livin in CRC remain not fully understood...
  57. Yang Z, Li D, Liu Z, Miao X, Yang L, Zou Q, et al. BIRC7 and KLF4 expression in benign and malignant lesions of pancreas and their clinicopathological significance. Cancer Biomark. 2016;17:437-444 pubmed publisher
    This study investigated the KLF4 and BIRC7 protein expression in malignant and benign pancreatic tissues by immunohistochemical staining and the clinical and pathological significance of KLF4 and BIRC7 expression in PDAC...
  58. Fontenas L, Kucenas S. Livin' On The Edge: glia shape nervous system transition zones. Curr Opin Neurobiol. 2017;47:44-51 pubmed publisher
    ..This review will highlight recent advances into the important role that glial cells play in building and maintaining the nervous system and its boundaries. ..
  59. El Mesallamy H, Hegab H, Kamal A. Expression of inhibitor of apoptosis protein (IAP) livin/BIRC7 in acute leukemia in adults: correlation with prognostic factors and outcome. Leuk Res. 2011;35:1616-22 pubmed publisher
    The clinical relevance of livin/BIRC7 expression is still controversial in different types of malignancies, therefore this study was designed to evaluate the gene expression of livin in Egyptian adult AML and ALL...
  60. Ding Z, Liu G, Olsson B, Sun X. Upregulation of the antiapoptotic factor Livin contributes to cisplatin resistance in colon cancer cells. Tumour Biol. 2013;34:683-93 pubmed publisher
    The antiapoptotic factor Livin has been considered critical for tumor progression and poor prognosis for variant types of tumors. However, there are only limited reports regarding its expression and biological functions in colon cancer...
  61. Guan H, Sun J, Feng X, Chen J, Chen F, Cheng X, et al. Effects of RNA interference-mediated knockdown of livin and survivin using monomethoxypolyethylene glycol-chitosan nanoparticles in MG-63 osteosarcoma cells. Mol Med Rep. 2016;13:1821-6 pubmed publisher
    MG-63 human osteosarcoma cells were transfected with short hairpin RNA (shRNA) against livin and survivin using monomethoxypolyethylene glycol‑chitosan (mPEG‑CS) nanoparticles (NPs) as carriers, with the aim of evaluating ..
  62. Kim S, Yoon T, Lee D, Lee J, Park Y, Chung I, et al. Livin enhances tumorigenesis by regulating the mitogen-activated protein kinase signaling pathway in human hypopharyngeal squamous cell carcinoma. Mol Med Rep. 2016;14:515-20 pubmed publisher
    b>Livin, a member of the human inhibitor of apoptosis protein (IAP) family, is expressed at high levels in various human cancer tissues and may have prognostic significance...
  63. Han Y, Zhang L, Wang W, Li J, Song M. Livin promotes the progression and metastasis of breast cancer through the regulation of epithelial?mesenchymal transition via the p38/GSK3? pathway. Oncol Rep. 2017;38:3574-3582 pubmed publisher
    Epithelial-mesenchymal transition (EMT) plays a pivotal role in the invasion and metastasis of breast cancer. Livin is a recently identified member of the inhibitors of the apoptosis protein family, which has been revealed to facilitate ..
  64. Peng X, Karna P, O Regan R, Liu X, Naithani R, Moriarty R, et al. Down-regulation of inhibitor of apoptosis proteins by deguelin selectively induces apoptosis in breast cancer cells. Mol Pharmacol. 2007;71:101-11 pubmed
  65. Gao J, Wang X, Liu X, Ge X, Ding M, Wang L. [Clinical significance of Livin expression in non-Hodgkin's lymphoma]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010;18:385-90 pubmed
    This study was aimed to explore clinical significance of Livin mRNA and protein expressions in non-Hodgkin's lymphoma (NHL)...
  66. Kalungi S, Wabinga H, Bostad L. Expression of apoptosis associated proteins Survivin, Livin and Thrombospondin-1 in Burkitt lymphoma. APMIS. 2013;121:239-45 pubmed publisher
    ..The aim of this study was to explore the expression of apoptosis related proteins Survivin, Livin and Thrombospondin-1 (TSP-1) in BL and comparing it with the expression in reactive follicular hyperplasia...
  67. Li F, Yin X, Luo X, Li H, Su X, Wang X, et al. Livin promotes progression of breast cancer through induction of epithelial-mesenchymal transition and activation of AKT signaling. Cell Signal. 2013;25:1413-22 pubmed publisher
    ..b>Livin is the most recently identified IAP, and its role in breast progression remains unknown...
  68. Chen S, Ma P, Li B, Zhu D, Chen X, Xiang Y, et al. LncRNA CCAT1 inhibits cell apoptosis of renal cell carcinoma through up-regulation of Livin protein. Mol Cell Biochem. 2017;434:135-142 pubmed publisher
    ..In this study, the expression of CCAT1 and Livin of RCC tissues or cells was determined using qRT-PCR (quantitative real-time PCR) and western blot, respectively...
  69. Arora V, Cheung H, Plenchette S, Micali O, Liston P, Korneluk R. Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex. J Biol Chem. 2007;282:26202-9 pubmed
    ..Immunoprecipitation studies indicate that XAF1 binds to XIAP, cIAP1, cIAP2, Livin, TsIAP, and NAIP but not Survivin, an IAP that prevents mitotic catastrophe and in which antiapoptotic activity is ..
  70. Yang D, Song X, Zhang J, Ye L, Wang S, Che X, et al. Suppression of livin gene expression by siRNA leads to growth inhibition and apoptosis induction in human bladder cancer T24 cells. Biosci Biotechnol Biochem. 2010;74:1039-44 pubmed
    ..b>Livin, the latest found inhibitor of apoptosis protein (IAP) family member, plays important role in cell growth and ..
  71. Jiang L, Li X, Bai L, Zhang L, Zhang C. [Expression of livin at the invasive tumor front of oral squamous cell carcinoma]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:1398-400 pubmed
    To study the expression of livin at the invasive tumor front of oral squamous cell carcinoma. Forty-eight samples of oral squamous cell carcinoma were graded according to invasive front gading (IFG)...
  72. Chen F, Yang D, Che X, Wang J, Li X, Zhang Z, et al. Livin mediates tumor cell invasion in the DU-145 cell line via NF-?B. Oncol Rep. 2012;27:2010-6 pubmed publisher
    b>Livin is a member of the family of inhibitors of apoptosis proteins (IAPs) and tumor cell invasion is a general property of multiple IAPs. Livin is highly expressed in prostate cancer (PCa) tissues...
  73. Li J, Chen P, Li X, Bao Q, Dai C, Ge L. Elevated levels of survivin and livin mRNA in bronchial aspirates as markers to support the diagnosis of lung cancer. Int J Cancer. 2013;132:1098-104 pubmed publisher
    Survivin and livin are two members of the inhibitor of apoptosis gene family, which have been found to be expressed in many human cancer tissues. But their expression could not be detected in normal adult tissue...
  74. Zou A, Wang H, Zhu W, Wang F, Shen J. Effect of RNAi-mediated silencing of Livin gene on biological properties of colon cancer cell line LoVo. Genet Mol Res. 2014;13:3832-41 pubmed publisher
    This study aimed to investigate the effect of RNAi-mediated silencing of the Livin gene on biological properties of the colon cancer cell line LoVo. Interference vectors pSilencer4.1-Ll and pSilencer4...
  75. Wang Z, Liu S, Ding K, Ding S, Li C, Lü J, et al. Silencing Livin induces apoptotic and autophagic cell death, increasing chemotherapeutic sensitivity to cisplatin of renal carcinoma cells. Tumour Biol. 2016;37:15133-15143 pubmed
    Renal cell carcinoma (RCC) accounts for 3 % of all adult malignancies and is the most lethal urological cancer. Livin is a member of the inhibitor of apoptosis protein (IAP) family, which is associated with tumor resistance to ..
  76. Zhu Z, Wang Y, Ding X, Zeng F, Xu K. Expression and prognostic significance of Livin in the progression of bladder cancer. J Huazhong Univ Sci Technolog Med Sci. 2008;28:90-2 pubmed publisher
    ..Recently Livin, belonging to the inhibitors of apoptosis (IAP) family, has been found to be expressed in most solid tumors, where ..
  77. Ibrahim L, Aladle D, Mansour A, Hammad A, Al Wakeel A, Abd El Hameed S. Expression and prognostic significance of livin/BIRC7 in childhood acute lymphoblastic leukemia. Med Oncol. 2014;31:941 pubmed publisher
    b>Livin, a member of the inhibitor of apoptosis proteins has been considered to be a poor prognostic marker in malignancies...
  78. Zhuang L, Shen L, Li K, Yang R, Zhang Q, Chen Y, et al. Inhibition of livin expression suppresses cell proliferation and enhances chemosensitivity to cisplatin in human lung adenocarcinoma cells. Mol Med Rep. 2015;12:547-52 pubmed publisher
    b>Livin is a novel member of the inhibitor of apoptosis protein family that has been reported to be overexpressed in various types of human malignancy...
  79. Wang H, Tan S, Wang X, Liu D, Yu C, Bai Z, et al. Silencing livin gene by siRNA leads to apoptosis induction, cell cycle arrest, and proliferation inhibition in malignant melanoma LiBr cells. Acta Pharmacol Sin. 2007;28:1968-74 pubmed
    The aim of the present study was to investigate the effects of silencing the livin gene by small interfering RNA (siRNA) on the expression of livin and the effects on apoptosis, cell cycle, and proliferation in human malignant melanoma ..
  80. Jin F, Zhao L, Guo Y, Zhao W, Zhang H, Wang H, et al. Influence of Etoposide on anti-apoptotic and multidrug resistance-associated protein genes in CD133 positive U251 glioblastoma stem-like cells. Brain Res. 2010;1336:103-11 pubmed publisher
    ..Real-time quantitative PCR was chosen for detecting mRNA expression of livin, livinalpha, livinbeta, survivin, MRP1 and MRP3...
  81. Tanhaei A, Ziaei A, Mazrouei S, Keyhanian K, Salehi M. Livin, a novel marker in lymphoma type distinction. Ann Diagn Pathol. 2014;18:157-62 pubmed publisher
    ..Considering high level of livin expression in hematologic malignancies, we aimed to examine the utility of livin expression ratio, as an ancillary ..
  82. Liang Y, Wang H, Sun Y, Chen S, Wang H, Huang R, et al. miR-198-induced upregulation of Livin may be associated with the prognosis and contribute to the oncogenesis of lung adenocarcinoma. Oncol Rep. 2017;38:2096-2104 pubmed publisher
    b>Livin, a member of the inhibitor of apoptosis protein (IAP) family, is expressed at a high level in lung adenocarcinoma and influences the progression of cancer, and its response to chemotherapy and radiotherapy...
  83. Yan H, Brouha B, Liu T, Raj D, Biddle D, Lee R, et al. Proteolytic cleavage of Livin (ML-IAP) in apoptotic melanoma cells potentially mediated by a non-canonical caspase. J Dermatol Sci. 2006;43:189-200 pubmed
    ..Studies of the melanoma-associated IAP (ML-IAP) Livin, using recombinant molecules, have implicated both caspases 3/7 and the serine protease Omi/HtrA2 in its ..
  84. Tan D, Sun Z. [Effects of bortezomib alone or combined with arsenic trioxide on the apoptosis of Jurkat cells and expression of livin mRNA]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011;19:898-901 pubmed
    ..effect of bortezomib alone or combined with arsenic trioxide on the apoptosis of Jurkat cells and expression of livin mRNA...
  85. Lin X, Li H, Lin X, Yu M, Tu X, Hua Z, et al. Silencing of Livin inhibits tumorigenesis and metastasis via VEGF and MMPs pathway in lung cancer. Int J Oncol. 2015;47:657-67 pubmed publisher
    b>Livin, an inhibitor of apoptosis protein (IAP), is overexpressed in various cancers and decreases tumor sensitivity to chemotherapy and radiotherapy...
  86. Luo J, Yu L, Xie G, Li D, Su M, Zhao X, et al. Study on the mitochondrial apoptosis pathways of small cell lung cancer H446 cells induced by Trichinella spiralis muscle larvae ESPs. Parasitology. 2017;144:793-800 pubmed publisher
    ..compared with the negative control group, and decreased the expression of anti-apoptosis genes Bcl-2 and Livin. Our results suggest that T...
  87. Wang H, Yang Y, Wang W, Guan B, Xun M, Zhang H, et al. Single-chain antibody-delivered Livin siRNA inhibits human malignant melanoma growth in vitro and in vivo. Tumour Biol. 2017;39:1010428317701645 pubmed publisher
    ..Our previous in vitro studies have found that the oncogene Livin could serve as a potential molecular target by small interfering RNA for gene therapy of malignant melanoma...
  88. Kempkensteffen C, Hinz S, Krause H, Jager T, Kollermann J, Weikert S, et al. Expression of splicing variants of the inhibitor of apoptosis livin in testicular germ cell tumors. Tumour Biol. 2008;29:76-82 pubmed publisher
    The inhibitor of apoptosis family member livin is expressed in several neoplasms but is absent in most benign tissues...
  89. Dasgupta A, Alvarado C, Xu Z, Findley H. Expression and functional role of inhibitor-of-apoptosis protein livin (BIRC7) in neuroblastoma. Biochem Biophys Res Commun. 2010;400:53-9 pubmed publisher
    We evaluated the expression of the inhibitor-of-apoptosis protein (IAP)livin (BIRC7)in 59 cases ofneuroblastoma (NBL) by quantitative RT-PCR. We also examined the role of livin in protecting tumor cells from chemotherapy drugs...
  90. Yuan B, Ran B, Wang S, Liu Z, Zheng Z, Chen H. siRNA directed against Livin inhibits tumor growth and induces apoptosis in human glioma cells. J Neurooncol. 2012;107:81-7 pubmed publisher
    b>Livin, a novel member of the human inhibitors of apoptosis protein family, plays an important role in tumor progression and occurrence by inhibiting cell apoptosis...