Bip

Summary

Gene Symbol: Bip
Description: heat shock protein family A (Hsp70) member 5
Alias: BIP, GRP78, HEL-S-89n, MIF2, endoplasmic reticulum chaperone BiP, 78 kDa glucose-regulated protein, HSP70 family protein 5, binding-immunoglobulin protein, endoplasmic reticulum lumenal Ca(2+)-binding protein grp78, epididymis secretory sperm binding protein Li 89n, glucose-regulated protein, 78kDa, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa), heat shock protein 70 family protein 5, heat shock protein family A member 5, immunoglobulin heavy chain-binding protein
Species: human
Products:     Bip

Top Publications

  1. Yeung B, Kwan B, He Q, Lee A, Liu J, Wong A. Glucose-regulated protein 78 as a novel effector of BRCA1 for inhibiting stress-induced apoptosis. Oncogene. 2008;27:6782-9 pubmed publisher
    ..We showed that overexpression of wild-type BRCA1 suppressed the expression of GRP78, whereas expression of mutant BRCA1 gene or targeted inhibition of endogenous BRCA1 using small-interfering RNA (..
  2. Zhu X, Chen M, Tian L, Li D, Xu P, Lin M, et al. Single nucleotide polymorphism of rs430397 in the fifth intron of GRP78 gene and clinical relevance of primary hepatocellular carcinoma in Han Chinese: risk and prognosis. Int J Cancer. 2009;125:1352-7 pubmed publisher
    Large number of data showed that allele variants in certain genes are markers for hepatocellular carcinoma (HCC). GRP78 is a stress-associated protein which is a central regulator of endoplasmic reticulum homeostasis due to its multiple ..
  3. Zhang Y, Tseng C, Tsai Y, Fu X, Schiff R, Lee A. Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 production. PLoS ONE. 2013;8:e80071 pubmed publisher
    Traditionally, GRP78 has been regarded as an endoplasmic reticulum (ER) lumenal protein due to its carboxyl KDEL retention motif...
  4. Misra U, Deedwania R, Pizzo S. Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK. J Biol Chem. 2005;280:26278-86 pubmed
    ..reported that binding of receptor-recognized forms of the proteinase inhibitor alpha2-macroglobulin (alpha2M*) to GRP78 on the cell surface of 1-LN human prostate cancer cells induces mitogenic signaling and cellular proliferation...
  5. Lee E, Nichols P, Spicer D, Groshen S, Yu M, Lee A. GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer. Cancer Res. 2006;66:7849-53 pubmed
    ..The 78-kDa glucose-regulated protein (GRP78), widely used as an indicator of the unfolded protein response (UPR), is induced in the tumor microenvironment...
  6. Goodwin E, Lipovsky A, Inoue T, Magaldi T, Edwards A, Van Goor K, et al. BiP and multiple DNAJ molecular chaperones in the endoplasmic reticulum are required for efficient simian virus 40 infection. MBio. 2011;2:e00101-11 pubmed publisher
    ..inhibited by up to 50-fold by knockdown of four different DNAJ molecular cochaperones or by inhibition of BiP, the Hsp70 partner of DNAJB11...
  7. Dana R, Welch W, Deftos L. Heat shock proteins bind calcitonin. Endocrinology. 1990;126:672-4 pubmed
    ..Additionally, HSP-peptide hormone interactions may confound studies designed to investigate classical receptor-hormone interactions. ..
  8. Munro S, Pelham H. An Hsp70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein. Cell. 1986;46:291-300 pubmed
    ..We show that it is identical with two previously described proteins: GRP78, whose synthesis is induced by glucose starvation, and BiP, which is found bound to immunoglobulin heavy chains in ..
  9. Uramoto H, Sugio K, Oyama T, Nakata S, Ono K, Yoshimastu T, et al. Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance. Lung Cancer. 2005;49:55-62 pubmed
    ..The aim of this study was to detect Grp78 expression in lung cancer using immunohistochemical (IHC) staining, and also to evaluate the relationship between ..

More Information

Publications127 found, 100 shown here

  1. Philippova M, Ivanov D, Joshi M, Kyriakakis E, Rupp K, Afonyushkin T, et al. Identification of proteins associating with glycosylphosphatidylinositol- anchored T-cadherin on the surface of vascular endothelial cells: role for Grp78/BiP in T-cadherin-dependent cell survival. Mol Cell Biol. 2008;28:4004-17 pubmed publisher
    ..liquid chromatography revealed putative association of T-cad with the following proteins: glucose-related protein GRP78, GABA-A receptor alpha1 subunit, integrin beta3, and two hypothetical proteins, LOC124245 and FLJ32070...
  2. Dong W, Li X, Feng Y, Fan C, Chen Z, Zhu P. The differential expressions of 78-kDa glucose-regulated protein of infiltrating plasma cells in peripheral joints with the histopathological variants of rheumatoid synovitis. Arthritis Res Ther. 2009;11:R4 pubmed publisher
  3. Jiang C, Mao Z, Avery Kiejda K, Wade M, Hersey P, Zhang X. Glucose-regulated protein 78 antagonizes cisplatin and adriamycin in human melanoma cells. Carcinogenesis. 2009;30:197-204 pubmed publisher
    ..chemotherapeutic drugs, cisplatin (CDDP) and adriamycin, and this is associated with glucose-regulated protein 78 (GRP78)-mediated inhibition of activation of caspase-4 and -7...
  4. Burikhanov R, Zhao Y, Goswami A, Qiu S, Schwarze S, Rangnekar V. The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis. Cell. 2009;138:377-88 pubmed publisher
    ..extracellular Par-4 induced apoptosis by binding to the stress response protein, glucose-regulated protein-78 (GRP78), expressed at the surface of cancer cells...
  5. Buchkovich N, Yu Y, Pierciey F, Alwine J. Human cytomegalovirus induces the endoplasmic reticulum chaperone BiP through increased transcription and activation of translation by using the BiP internal ribosome entry site. J Virol. 2010;84:11479-86 pubmed publisher
    The endoplasmic reticulum (ER) chaperone BiP (immunoglobulin binding protein) plays a major role in the control of the unfolded protein response...
  6. Liu R, Li X, Gao W, Zhou Y, Wey S, Mitra S, et al. Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis. Clin Cancer Res. 2013;19:6802-11 pubmed publisher
    The ER chaperone GRP78 translocates to the surface of tumor cells and promotes survival, metastasis, and resistance to therapy...
  7. Shen Y, Hendershot L. ERdj3, a stress-inducible endoplasmic reticulum DnaJ homologue, serves as a cofactor for BiP's interactions with unfolded substrates. Mol Biol Cell. 2005;16:40-50 pubmed
    We recently identified ERdj3 as a component of unassembled immunoglobulin (Ig) heavy chain:BiP complexes...
  8. Baumeister P, Luo S, Skarnes W, Sui G, Seto E, Shi Y, et al. Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers. Mol Cell Biol. 2005;25:4529-40 pubmed
    ..The transcriptional activation of the promoter of GRP78/BiP, a prosurvival ER chaperone, has been used extensively as an indicator of the onset of the UPR...
  9. Xu D, Perez R, Rezaiekhaligh M, Bourdi M, Truog W. Knockdown of ERp57 increases BiP/GRP78 induction and protects against hyperoxia and tunicamycin-induced apoptosis. Am J Physiol Lung Cell Mol Physiol. 2009;297:L44-51 pubmed publisher
    ..or tunicamycin was diminished and immunoglobulin heavy chain-binding protein/glucose-regulated protein 78-kDa (BiP/GRP78) induction was increased in ERp57 knockdown cells...
  10. Hosokawa N, Wada I, Nagasawa K, Moriyama T, Okawa K, Nagata K. Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. J Biol Chem. 2008;283:20914-24 pubmed publisher
    ..that the hXTP3-B long isoform associates with the HRD1-SEL1L membrane-anchored ubiquitin ligase complex and BiP, forming a 27 S ER quality control scaffold complex...
  11. Tsai H, Yang Y, Wu A, Yang C, Liu Y, Jan Y, et al. Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78. Oncogene. 2013;32:4921-31 pubmed publisher
    ..This effect was associated with a significant reduction in the expression of glucose-regulated protein 78 (GRP78)...
  12. Christianson J, Shaler T, Tyler R, Kopito R. OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. Nat Cell Biol. 2008;10:272-82 pubmed publisher
    ..These data suggest that XTP3-B and OS-9 are components of distinct, partially redundant, quality control surveillance pathways that coordinate protein folding with membrane dislocation and ubiquitin conjugation in mammalian cells. ..
  13. Li N, Zoubeidi A, Beraldi E, Gleave M. GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer. Oncogene. 2013;32:1933-42 pubmed publisher
    ..Here, we show using human prostate cancer cells that GRP78 (Bip) associates with CLU under ER stress conditions to facilitate its retrotranslocation and redistribution to ..
  14. Ting J, Lee A. Human gene encoding the 78,000-dalton glucose-regulated protein and its pseudogene: structure, conservation, and regulation. DNA. 1988;7:275-86 pubmed
    The isolation and characterization of a human functional GRP78 gene and a processed pseudogene are described. We present the complete primary structure of the human GRP78 gene, which spans over 5 kb and consists of eight exons...
  15. Buchkovich N, Maguire T, Paton A, Paton J, Alwine J. The endoplasmic reticulum chaperone BiP/GRP78 is important in the structure and function of the human cytomegalovirus assembly compartment. J Virol. 2009;83:11421-8 pubmed publisher
    We previously demonstrated that the endoplasmic reticulum (ER) chaperone BiP functions in human cytomegalovirus (HCMV) assembly and egress. Here, we show that BiP localizes in two cytoplasmic structures in infected cells...
  16. Matsuo K, Gray M, Yang D, Srivastava S, Tripathi P, Sonoda L, et al. The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival. Gynecol Oncol. 2013;128:552-9 pubmed publisher
    ..To ascertain if changes in the endoplasmic reticulum (ER) stress marker, glucose-regulated-protein-78 (GRP78) can serve as a prognosticator in endometrial cancer, we examined GRP78 expression in patient samples to determine ..
  17. Zheng Y, Cao Z, Hu X, Shao Z. The endoplasmic reticulum stress markers GRP78 and CHOP predict disease-free survival and responsiveness to chemotherapy in breast cancer. Breast Cancer Res Treat. 2014;145:349-58 pubmed publisher
    ..As an ER chaperone, GRP78 functions as a potent anti-apoptotic factor and confers drug resistance, whereas CHOP is a key initiating factor ..
  18. Chiu C, Lin C, Lee L, Chen Y, Kuo T, Chang J, et al. Glucose-regulated protein 78 regulates multiple malignant phenotypes in head and neck cancer and may serve as a molecular target of therapeutic intervention. Mol Cancer Ther. 2008;7:2788-97 pubmed publisher
    Glucose-regulated protein 78 (Grp78) is an endoplasmic reticulum chaperone protein and is overexpressed in various cancers...
  19. Zhu X, Wang Y, Tao T, Li D, Lan F, Zhu W, et al. A new polymorphism in the GRP78 is not associated with HBV invasion. World J Gastroenterol. 2009;15:4958-61 pubmed
    To examine the association between -86 bp (T > A) in the glucose-regulated protein 78 gene (GRP78) and hepatitis B virus (HBV) invasion...
  20. Arnaudeau S, Arboit P, Bischof P, Shin ya K, Tomida A, Tsuruo T, et al. Glucose-regulated protein 78: a new partner of p53 in trophoblast. Proteomics. 2009;9:5316-27 pubmed publisher
    ..Among these proteins, we identified glucose-regulated protein 78 (GRP78) and verified its interaction with p53 in trophoblastic cells by immunoprecipitation and Western blot analysis...
  21. Rao R, Nalluri S, Kolhe R, Yang Y, Fiskus W, Chen J, et al. Treatment with panobinostat induces glucose-regulated protein 78 acetylation and endoplasmic reticulum stress in breast cancer cells. Mol Cancer Ther. 2010;9:942-52 pubmed publisher
    ..polypeptides in the endoplasmic reticulum (ER) triggers the dissociation of glucose-regulated protein 78 (GRP78) from the three transmembrane ER-stress mediators, i.e...
  22. Sun Q, Hua J, Wang Q, Xu W, Zhang J, Zhang J, et al. Expressions of GRP78 and Bax associate with differentiation, metastasis, and apoptosis in non-small cell lung cancer. Mol Biol Rep. 2012;39:6753-61 pubmed publisher
    The purpose of this study was to detect the expressions of GRP78 and Bax in human non-small cell lung cancer (NSCLC) tissues, to analyze their correlations with carcinogenesis and the development of NSCLC, and to investigate the ..
  23. Xing X, Lai M, Wang Y, Xu E, Huang Q. Overexpression of glucose-regulated protein 78 in colon cancer. Clin Chim Acta. 2006;364:308-15 pubmed
    The 78 kDa glucose-regulated protein (GRP78) has been implicated in the development of tumorigenicity, drug resistance, and cytotoxic immunology...
  24. Dong M, Bridges J, Apsley K, Xu Y, Weaver T. ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C. Mol Biol Cell. 2008;19:2620-30 pubmed publisher
    ..b>Immunoglobulin heavy chain binding protein (BiP) and two heat shock protein 40 family members, endoplasmic reticulum-localized DnaJ ..
  25. Daneshmand S, Quek M, Lin E, Lee C, Cote R, Hawes D, et al. Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival. Hum Pathol. 2007;38:1547-52 pubmed
    ..We sought to determine the level of expression of GRP78, the best characterized GRP in lymph node-positive prostate cancer...
  26. Li M, Wang J, Jing J, Hua H, Luo T, Xu L, et al. Synergistic promotion of breast cancer cells death by targeting molecular chaperone GRP78 and heat shock protein 70. J Cell Mol Med. 2009;13:4540-50 pubmed publisher
    ..response (UPR) and addressed a novel strategy to enhance the proapoptotic effect of quercetin by suppressing GRP78 induction simultaneously...
  27. Wei P, Hsieh Y, Su M, Jiang X, Hsu P, Lo W, et al. Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease. Mol Cell. 2012;48:747-59 pubmed publisher
    ..protein (GRP)78 and forms covalent bonding intermediates between Cys86 of NPGPx and Cys41/Cys420 of GRP78. Subsequently, the formation of the disulfide bond between Cys41 and Cys420 of GRP78 enhances its chaperone ..
  28. Zhang X, Li H, Zhao S, Zhao L, Song H, Wang G, et al. The cell surface GRP78 facilitates the invasion of hepatocellular carcinoma cells. Biomed Res Int. 2013;2013:917296 pubmed publisher
    ..We have previously reported that GRP78 promotes the invasion of hepatocellular carcinoma although the mechanism underlying this change remains uncertain...
  29. Chung K, Shen Y, Hendershot L. BAP, a mammalian BiP-associated protein, is a nucleotide exchange factor that regulates the ATPase activity of BiP. J Biol Chem. 2002;277:47557-63 pubmed
    We identified a mammalian BiP-associated protein, BAP, using a yeast two-hybrid screen that shared low homology with yeast Sls1p/Sil1p and mammalian HspBP1, both of which regulate the ATPase activity of their Hsp70 partner...
  30. Cunnea P, Miranda Vizuete A, Bertoli G, Simmen T, Damdimopoulos A, Hermann S, et al. ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress. J Biol Chem. 2003;278:1059-66 pubmed
    ..In vitro experiments demonstrated that ERdj5 interacts via its DnaJ domain with BiP in an ATP-dependent manner...
  31. Hong M, Lin M, Huang J, Baumeister P, Hakre S, Roy A, et al. Transcriptional regulation of the Grp78 promoter by endoplasmic reticulum stress: role of TFII-I and its tyrosine phosphorylation. J Biol Chem. 2005;280:16821-8 pubmed
    ..binding to the ER stress element, which is highly conserved in promoters of ER stress-inducible genes such as Grp78/BiP. Interestingly, its tyrosine phosphorylation sites are required for its activation of the Grp78 promoter...
  32. Su R, Li Z, Li H, Song H, Bao C, Wei J, et al. Grp78 promotes the invasion of hepatocellular carcinoma. BMC Cancer. 2010;10:20 pubmed publisher
    Glucose regulated protein 78 (Grp78) is involved in the invasion and metastasis in many human cancers including gastric cancer, breast cancer, prostate cancer...
  33. Defresne F, Bouzin C, Guilbaud C, Dieu M, Delaive E, Michiels C, et al. Differential influence of anticancer treatments and angiogenesis on the seric titer of autoantibody used as tumor and metastasis biomarker. Neoplasia. 2010;12:562-70 pubmed
    ..40 serum-reactive proteins identified by multiplex analysis, we chose to focus on glucose-regulated protein 78 (GRP78), a chaperone protein involved in the endoplasmic reticulum stress response...
  34. Anttonen A, Mahjneh I, Hämäläinen R, Lagier Tourenne C, Kopra O, Waris L, et al. The gene disrupted in Marinesco-Sjögren syndrome encodes SIL1, an HSPA5 cochaperone. Nat Genet. 2005;37:1309-11 pubmed
    ..These data, together with the similar spatial and temporal patterns of tissue expression of Sil1 and Hspa5, suggest that disturbed SIL1-HSPA5 interaction and protein folding is the primary pathology in Marinesco-Sjögren syndrome...
  35. Zhu X, Li D, Fan W, Lin M, Wang J, Lin S, et al. Lack of association between the GRP78 polymorphisms in the promoter and 3' UTR and susceptibility to chronic HBV infection in a Chinese Han population. BMC Med Genet. 2010;11:83 pubmed publisher
    ..in the endoplasmic reticulum (ER), which in turn induces the expression of glucose-regulated protein 78 (GRP78)...
  36. Cook K, Shajahan A, Warri A, Jin L, Hilakivi Clarke L, Clarke R. Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness. Cancer Res. 2012;72:3337-49 pubmed publisher
    ..We investigated the potential role of glucose-regulated protein 78 (GRP78) in mediating estrogen resistance...
  37. Ni M, Zhou H, Wey S, Baumeister P, Lee A. Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP. PLoS ONE. 2009;4:e6868 pubmed publisher
    ..Induction of ER chaperone GRP78/BiP increases protein folding capacity; as such it represents a major survival arm of UPR...
  38. Wang M, Ye R, Barron E, Baumeister P, Mao C, Luo S, et al. Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis. Cell Death Differ. 2010;17:488-98 pubmed publisher
    ..In this study we report the creation of a novel mouse model in which GRP78/BiP, a major ER chaperone and master regulator of UPR, is specifically eliminated in Purkinje cells (PCs)...
  39. Lee E, Nichols P, Groshen S, Spicer D, Lee A. GRP78 as potential predictor for breast cancer response to adjuvant taxane therapy. Int J Cancer. 2011;128:726-31 pubmed publisher
    ..The 78-kDa glucose-regulated protein (GRP78) is a potent antiapoptotic factor, conferring drug resistance...
  40. Dong D, Stapleton C, Luo B, Xiong S, Ye W, Zhang Y, et al. A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis. Cancer Res. 2011;71:2848-57 pubmed publisher
    Glucose-regulated protein 78 (GRP78)/BiP is a multifunctional protein which plays a major role in endoplasmic reticulum (ER) protein processing, protein quality control, maintaining ER homeostasis, and controlling cell signaling and ..
  41. Zhu X, Zhang J, Fan W, Wang F, Yao H, Wang Z, et al. The rs391957 variant cis-regulating oncogene GRP78 expression contributes to the risk of hepatocellular carcinoma. Carcinogenesis. 2013;34:1273-80 pubmed publisher
    Glucose-regulated protein 78 (GRP78) is one of the most important responders to disease-related stress...
  42. Rao R, Peel A, Logvinova A, Del Rio G, Hermel E, Yokota T, et al. Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. FEBS Lett. 2002;514:122-8 pubmed
    ..Glucose-regulated protein (GRP) 78 (Bip) is an ER lumen protein whose expression is induced during ER stress. GRP78 is involved in polypeptide translocation across the ER membrane, and also acts as an apoptotic regulator by ..
  43. Hsu W, Wang H, Lee L, Fung H, Lin J, Hsu H, et al. Promoter polymorphisms modulating HSPA5 expression may increase susceptibility to Taiwanese Alzheimer's disease. J Neural Transm (Vienna). 2008;115:1537-43 pubmed publisher
    Endoplasmic reticulum (ER) chaperone heat shock 70 kDa protein 5 (HSPA5/GRP78) is known to be involved in the metabolism of amyloid precursor protein and neuronal death in Alzheimer's disease (AD) could arise from dysfunction of the ER...
  44. Zhu X, Lin M, Fan W, Tian L, Wang J, Ng S, et al. An intronic polymorphism in GRP78 improves chemotherapeutic prediction in non-small cell lung cancer. Chest. 2012;141:1466-1472 pubmed publisher
    Glucose-regulated protein 78 (GRP78) is involved in not only the progression of non-small cell lung cancer (NSCLC) but also chemotherapeutic effects...
  45. Li Z, Zhang L, Li H, Shan S, Li Z. Glucose regulated protein 78 promotes cell invasion via regulation of uPA production and secretion in colon cancer cells. BMB Rep. 2014;47:445-50 pubmed
    Glucose regulated protein 78 (GRP78) is frequently highly expressed in tumor cells, contributing to the acquisition of several phenotypic cancer hallmarks...
  46. Langer R, Feith M, Siewert J, Wester H, Hoefler H. Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus. BMC Cancer. 2008;8:70 pubmed publisher
    ..In this study we investigated the glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in a series of human esophageal adenocarcinomas to determine their implications in cancer ..
  47. Petrova K, Oyadomari S, Hendershot L, Ron D. Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3. EMBO J. 2008;27:2862-72 pubmed publisher
    ..protein and challenge of that complex with physiological concentrations of the ER lumenal Hsp70-type chaperone BiP encourages disassembly...
  48. Wu M, Jan C, Tsay Y, Yu Y, Huang C, Lin S, et al. Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling. Mol Cancer. 2010;9:283 pubmed publisher
    ..However, the molecular mechanisms by which to govern the characteristics of HN-CICs remain unclear. GRP78, a stress-inducible endoplasmic reticulum chaperone, has been reported to play a crucial role in the maintenance ..
  49. Shani G, Fischer W, Justice N, Kelber J, Vale W, Gray P. GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth. Mol Cell Biol. 2008;28:666-77 pubmed
    ..This screen led to our identification of glucose-regulated protein 78 (GRP78), an endoplasmic reticulum (ER) chaperone that is also expressed at the surfaces of tumor cells...
  50. Kuroda K, Horiguchi A, Asano T, Ito K, Asakuma J, Sato A, et al. Glucose-regulated protein 78 positivity as a predictor of poor survival in patients with renal cell carcinoma. Urol Int. 2011;87:450-6 pubmed publisher
    Glucose-regulated protein 78 (GRP78), a chaperone for newly formed proteins during folding and glycosylation, is associated with resistance to apoptosis in some forms of cancer...
  51. Kandala P, Srivastava S. Regulation of macroautophagy in ovarian cancer cells in vitro and in vivo by controlling glucose regulatory protein 78 and AMPK. Oncotarget. 2012;3:435-49 pubmed
    ..Furthermore, DIM treatment significantly increased the expression of ER stress regulators such as Grp78, IRE1 and GADD153...
  52. Ravindran S, Narayanan K, Eapen A, Hao J, Ramachandran A, Blond S, et al. Endoplasmic reticulum chaperone protein GRP-78 mediates endocytosis of dentin matrix protein 1. J Biol Chem. 2008;283:29658-70 pubmed publisher
    ..Therefore, binding of DMP1 with GRP-78 receptor might be an important mechanism by which DMP1 is internalized and transported to the nucleus during bone and tooth development. ..
  53. Lu M, Lai N, Yu H, Huang H, Hsieh S, Yu C. Anti-citrullinated protein antibodies bind surface-expressed citrullinated Grp78 on monocyte/macrophages and stimulate tumor necrosis factor alpha production. Arthritis Rheum. 2010;62:1213-23 pubmed publisher
    ..Proteomic analysis revealed that Grp78 protein (72 kd) was one of the cognate antigens of ACPAs...
  54. Zhang L, Zhang X. Roles of GRP78 in physiology and cancer. J Cell Biochem. 2010;110:1299-305 pubmed publisher
    As one member of 70 kDa heat shock proteins, glucose-regulated protein 78 (GRP78) participates in protein folding, transportation and degradation. This sort of capacity can be enhanced by stresses under which GRP78 is induced rapidly...
  55. Shu C, Sun F, Cho J, Lin C, Liu P, Chen P, et al. GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis. J Cell Physiol. 2008;215:627-35 pubmed
    The chaperone glucose-regulated protein, 78/immunoglobulin binding protein (GRP78/Bip), protects cells from cytotoxicity induced by DNA damage or endoplasmic reticulum (ER) stress...
  56. Kelber J, Panopoulos A, Shani G, Booker E, Belmonte J, Vale W, et al. Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways. Oncogene. 2009;28:2324-36 pubmed publisher
    ..demonstrated that Cripto forms a cell surface complex with the HSP70 family member glucose-regulated protein-78 (GRP78)...
  57. Cho D, Yang G, Ryu C, Hong H. Molecular chaperone GRP78/BiP interacts with the large surface protein of hepatitis B virus in vitro and in vivo. J Virol. 2003;77:2784-8 pubmed
    ..In this study, we demonstrated that an endoplasmic reticulum luminal chaperone GRP78/BiP bound specifically to the pre-S1 domain of the L protein in vitro and in vivo where complete viral particles ..
  58. Kakiuchi C, Ishiwata M, Nanko S, Kunugi H, Minabe Y, Nakamura K, et al. Functional polymorphisms of HSPA5: possible association with bipolar disorder. Biochem Biophys Res Commun. 2005;336:1136-43 pubmed
    ..Previously, we preliminarily reported the genetic association of HSPA5 (GRP78/BiP) with bipolar disorder...
  59. Pootrakul L, Datar R, Shi S, Cai J, Hawes D, Groshen S, et al. Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer. Clin Cancer Res. 2006;12:5987-93 pubmed
    Induction of molecular chaperone Grp78 (78-kDa glucose-regulated protein) occurs in stress conditions that often characterize tumor microenvironments...
  60. Virrey J, Dong D, Stiles C, Patterson J, Pen L, Ni M, et al. Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells. Mol Cancer Res. 2008;6:1268-75 pubmed publisher
    ..We report here that the endoplasmic reticulum chaperone GRP78/BiP is generally highly elevated in the vasculature derived from human glioma specimens, both in situ in tissue ..
  61. Jin Y, Awad W, Petrova K, Hendershot L. Regulated release of ERdj3 from unfolded proteins by BiP. EMBO J. 2008;27:2873-82 pubmed publisher
    ..We examined the requirements for the release of ERdj3, a mammalian ER DnaJ, from substrates and found that BiP promoted the release of ERdj3 only in the presence of ATP...
  62. Ma Y, Yu J, Chan H, Chen Y, Wang H, Chen Y, et al. Glucose-regulated protein 78 is an intracellular antiviral factor against hepatitis B virus. Mol Cell Proteomics. 2009;8:2582-94 pubmed publisher
    ..Twenty-three proteins were identified as differentially expressed with glucose-regulated protein 78 (GRP78) as one of the most significantly up-regulated proteins induced by HBV replication...
  63. Winder T, Bohanes P, Zhang W, Yang D, Power D, Ning Y, et al. GRP78 promoter polymorphism rs391957 as potential predictor for clinical outcome in gastric and colorectal cancer patients. Ann Oncol. 2011;22:2431-9 pubmed publisher
    ..the analysis of gastric and colorectal tumor specimens determined that 78-kiloDalton glucose-regulated protein (GRP78), an endoplasmic reticulum chaperone, up-regulation serves as an efficient mechanism protecting cells against ..
  64. Guzel E, Basar M, Ocak N, Arici A, Kayisli U. Bidirectional interaction between unfolded-protein-response key protein HSPA5 and estrogen signaling in human endometrium. Biol Reprod. 2011;85:121-7 pubmed publisher
    ..Heat shock 70 kDa protein (HSPA5; also known as GRP78/BiP), a molecular chaperone within the endoplasmic reticulum, plays crucial roles in normal cellular processes as ..
  65. Li Z, Wang Y, Wu H, Zhang L, Yang P, Li Z. GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the ?-catenin signaling. Oncotarget. 2014;5:5369-80 pubmed
    ..Though glucose regulated protein 78 (GRP78) is a glucose-sensing protein and frequently highly expressed in tumor cells, its roles in glucose and glutamine ..
  66. Miyake H, Hara I, Arakawa S, Kamidono S. Stress protein GRP78 prevents apoptosis induced by calcium ionophore, ionomycin, but not by glycosylation inhibitor, tunicamycin, in human prostate cancer cells. J Cell Biochem. 2000;77:396-408 pubmed
    b>GRP78 induction has recently been shown to play a critical role in maintaining cell viability against several kinds of stress, including depletion of endoplasmic reticulum Ca(2+) and accumulation of unglycosylated proteins, under ..
  67. Triantafilou K, Fradelizi D, Wilson K, Triantafilou M. GRP78, a coreceptor for coxsackievirus A9, interacts with major histocompatibility complex class I molecules which mediate virus internalization. J Virol. 2002;76:633-43 pubmed
    ..We document by protein isolation and peptide sequencing that the 70-kDa protein is GRP78, a member of the heat shock protein 70 family of stress proteins...
  68. Oyadomari S, Mori M. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 2004;11:381-9 pubmed
    ..Here, we summarize the current understanding of the roles of CHOP/GADD153 in ER stress-mediated apoptosis and in diseases including diabetes, brain ischemia and neurodegenerative disease. ..
  69. Dudek J, Benedix J, Cappel S, Greiner M, Jalal C, Muller L, et al. Functions and pathologies of BiP and its interaction partners. Cell Mol Life Sci. 2009;66:1556-69 pubmed publisher
    ..The central player in all these processes is the ER-lumenal polypeptide chain binding protein BiP that acts as a molecular chaperone...
  70. Zhang L, Wang S, Wangtao -, Wang Y, Wang J, Jiang L, et al. Upregulation of GRP78 and GRP94 and its function in chemotherapy resistance to VP-16 in human lung cancer cell line SK-MES-1. Cancer Invest. 2009;27:453-8 pubmed publisher
    The upregulation of GRP78 and GRP94 under the induction of A23187 and its function in drug resistance to etoposide (VP-16) was investigated in human lung cancer cell line SK-MES-1...
  71. Zhang L, Yang X, Zhang X, Cheng J, Zhang W. Association of elevated GRP78 expression with increased astrocytoma malignancy via Akt and ERK pathways. Brain Res. 2011;1371:23-31 pubmed publisher
    Unlike other members of HSP70 family, GRP78 manifests multifaceted subcellular distribution and forms complex with different signals, resulting in its close correlation with various tumors...
  72. Gray P, Vale W. Cripto/GRP78 modulation of the TGF-? pathway in development and oncogenesis. FEBS Lett. 2012;586:1836-45 pubmed publisher
    ..the biological roles and signaling mechanisms of Cripto, highlighting our identification of the 78 kDa glucose regulated protein (GRP78) as a cell surface receptor/co-factor required for Cripto signaling via both TGF-? and Src/..
  73. Ravindran S, Gao Q, Ramachandran A, Sundivakkam P, Tiruppathi C, George A. Expression and distribution of grp-78/bip in mineralizing tissues and mesenchymal cells. Histochem Cell Biol. 2012;138:113-25 pubmed publisher
    ..Collectively, our observations provide a new perspective on GRP-78 with respect to mineralized matrix formation. ..
  74. Chevalier M, Rhee H, Elguindi E, Blond S. Interaction of murine BiP/GRP78 with the DnaJ homologue MTJ1. J Biol Chem. 2000;275:19620-7 pubmed
    ..BiP/GRP78 chaperones the translocation and maturation of secreted and membrane proteins in the endoplasmic reticulum...
  75. Luk J, Lam C, Siu A, Lam B, Ng I, Hu M, et al. Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values. Proteomics. 2006;6:1049-57 pubmed
    ..007) whereas up-regulation of GRP78 was associated with tumor venous infiltration (P = 0.035)...
  76. Gonzalez Gronow M, Kaczowka S, Payne S, Wang F, Gawdi G, Pizzo S. Plasminogen structural domains exhibit different functions when associated with cell surface GRP78 or the voltage-dependent anion channel. J Biol Chem. 2007;282:32811-20 pubmed
    ..We show that kringle 5 inhibits 1-LN cell proliferation and promotes caspase-7 activity by a mechanism that requires binding to cell surface voltage-dependent anion channel and is inhibited by human hexokinase I. ..
  77. Suzuki T, Lu J, Zahed M, Kita K, Suzuki N. Reduction of GRP78 expression with siRNA activates unfolded protein response leading to apoptosis in HeLa cells. Arch Biochem Biophys. 2007;468:1-14 pubmed
    The 78-kDa glucose-regulated protein GRP78 is a central regulator of endoplasmic reticulum (ER) homeostasis, functioning in protein folding, ER calcium binding and modulation of transmembrane ER stress sensor activity...
  78. Lee A. The Par-4-GRP78 TRAIL, more twists and turns. Cancer Biol Ther. 2009;8:2103-5 pubmed
    b>GRP78, also referred to as BiP, is an essential molecular chaperone and a master regulator of the unfolded protein response. Traditionally, GRP78 is regarded as localized in the lumen of the endoplasmic reticulum (ER)...
  79. Xing X, Li Y, Liu H, Wang L, Sun L. Glucose regulated protein 78 (GRP78) is overexpressed in colorectal carcinoma and regulates colorectal carcinoma cell growth and apoptosis. Acta Histochem. 2011;113:777-82 pubmed publisher
    Glucose regulated protein 78 (GRP78) plays an important role in the development and progression of cancer. However, the role of GRP78 in colorectal carcinoma still remains unclear...
  80. Li H, Song H, Luo J, Liang J, Zhao S, Su R. Knockdown of glucose-regulated protein 78 decreases the invasion, metalloproteinase expression and ECM degradation in hepatocellular carcinoma cells. J Exp Clin Cancer Res. 2012;31:39 pubmed publisher
    We have reported previously that overexpression of glucose-regulated protein 78 (GRP78) promotes the invasion of hepatocellular carcinoma...
  81. Ray R, de Ridder G, Eu J, Paton A, Paton J, Pizzo S. The Escherichia coli subtilase cytotoxin A subunit specifically cleaves cell-surface GRP78 protein and abolishes COOH-terminal-dependent signaling. J Biol Chem. 2012;287:32755-69 pubmed
    b>GRP78, a molecular chaperone with critical endoplasmic reticulum functions, is aberrantly expressed on the surface of cancer cells, including prostate and melanoma...
  82. Wang C, Jiang K, Gao D, Kang X, Sun C, Zhang Q, et al. Clusterin protects hepatocellular carcinoma cells from endoplasmic reticulum stress induced apoptosis through GRP78. PLoS ONE. 2013;8:e55981 pubmed publisher
    ..We found that the expressions of both CLU and GRP78 were increased after TN treatment...
  83. Reddy R, Mao C, Baumeister P, Austin R, Kaufman R, Lee A. Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J Biol Chem. 2003;278:20915-24 pubmed
    ..We report here that without the use of endoplasmic reticulum (ER) stress inducers, specific overexpression of GRP78 results in reduced apoptosis and higher colony survival when challenged with topoisomerase II inhibitors, ..
  84. Hsu W, Hsieh F, Jeng Y, Kuo M, Tsao P, Lee H, et al. GRP78 expression correlates with histologic differentiation and favorable prognosis in neuroblastic tumors. Int J Cancer. 2005;113:920-7 pubmed
    Glucose-regulated protein 78 (GRP78), an endoplasmic reticulum protein, is essential for the differentiation of neuroblastoma cells and is selectively induced when the cells are undergoing apoptosis...
  85. Li J, Lee A. Stress induction of GRP78/BiP and its role in cancer. Curr Mol Med. 2006;6:45-54 pubmed
    b>GRP78, also referred to as BiP, is a central regulator of endoplasmic reticulum (ER) function due to its roles in protein folding and assembly, targeting misfolded protein for degradation, ER Ca(2+)-binding and controlling the activation ..
  86. Rauschert N, Brandlein S, Holzinger E, Hensel F, Muller Hermelink H, Vollmers H. A new tumor-specific variant of GRP78 as target for antibody-based therapy. Lab Invest. 2008;88:375-86 pubmed publisher
    The chaperone GRP78 is a member of the heat-shock protein 70 (HSP70) family and is responsible for cellular homeostasis by preventing stress-induced apoptosis. GRP78 is expressed in all cells of the body...
  87. Zheng H, Takahashi H, Li X, Hara T, Masuda S, Guan Y, et al. Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas. Hum Pathol. 2008;39:1042-9 pubmed publisher
    ..b>GRP78 and GRP94 expression was induced by glucose starvation and up-regulated in the malignancies...
  88. Zhang Y, Liu R, Ni M, Gill P, Lee A. Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP. J Biol Chem. 2010;285:15065-75 pubmed publisher
    The recent discovery that GRP78/BiP, a typical endoplasmic reticulum (ER) lumenal chaperone, can be expressed on the cell surface, interacting with an increasing repertoire of surface proteins and acting as receptor in signaling pathways,..
  89. Misra U, Payne S, Pizzo S. Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen. J Biol Chem. 2011;286:1248-59 pubmed publisher
    b>GRP78, a well characterized chaperone in the endoplasmic reticulum, is critical to the unfolded protein response. More recently, it has been identified on the cell surface, where it has many roles...
  90. Wu Y, Chang C, Hung C, Tsai M, Schuyler S, Wang R. Japanese encephalitis virus co-opts the ER-stress response protein GRP78 for viral infectivity. Virol J. 2011;8:128 pubmed publisher
    ..Five proteins were identified, including the molecular chaperones Hsp90, GRP78, and Hsp70. The functional role of GRP78 in the JEV life cycle was then investigated...
  91. Takahashi H, Wang J, Zheng H, Masuda S, Takano Y. Overexpression of GRP78 and GRP94 is involved in colorectal carcinogenesis. Histol Histopathol. 2011;26:663-71 pubmed publisher
    ..b>GRP78 and GRP94 expression was induced by glucose starvation and up-regulated in samples taken from several different ..
  92. Grkovic S, O Reilly V, Han S, Hong M, Baxter R, Firth S. IGFBP-3 binds GRP78, stimulates autophagy and promotes the survival of breast cancer cells exposed to adverse microenvironments. Oncogene. 2013;32:2412-20 pubmed publisher
    ..The endoplasmic reticulum protein, glucose-regulated protein 78 (GRP78), was shown to bind to IGFBP-3, confirmed by colocalization, coimmunoprecipitations, glutathione S-transferase (..