BIN1

Summary

Gene Symbol: BIN1
Description: bridging integrator 1
Alias: AMPH2, AMPHL, CNM2, SH3P9, myc box-dependent-interacting protein 1, amphiphysin II, amphiphysin-like protein, box dependant MYC interacting protein 1, box-dependent myc-interacting protein 1
Species: human
Products:     BIN1

Top Publications

  1. Meunier B, Quaranta M, Daviet L, Hatzoglou A, Leprince C. The membrane-tubulating potential of amphiphysin 2/BIN1 is dependent on the microtubule-binding cytoplasmic linker protein 170 (CLIP-170). Eur J Cell Biol. 2009;88:91-102 pubmed publisher
    ..This effect on lipid membranes is fulfilled by diverse amphiphysin 2/BIN1 isoforms, generated by alternative splicing and showing distinct structural and functional properties...
  2. Chang M, Boulden J, Katz J, Wang L, Meyer T, Soler A, et al. Bin1 ablation increases susceptibility to cancer during aging, particularly lung cancer. Cancer Res. 2007;67:7605-12 pubmed
    ..b>Bin1 is a prototypic member of the BAR adapter gene family that functions in vesicle dynamics and nuclear processes...
  3. Nicot A, Toussaint A, Tosch V, Kretz C, Wallgren Pettersson C, Iwarsson E, et al. Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy. Nat Genet. 2007;39:1134-9 pubmed
    ..By direct sequencing of functional candidate genes, we identified homozygous mutations in amphiphysin 2 (BIN1) in three families with autosomal recessive inheritance...
  4. Hong T, Smyth J, Gao D, Chu K, Vogan J, Fong T, et al. BIN1 localizes the L-type calcium channel to cardiac T-tubules. PLoS Biol. 2010;8:e1000312 pubmed publisher
    ..In particular, the membrane scaffolding protein BIN1 functions to initiate T-tubule genesis in skeletal muscle cells...
  5. Seshadri S, Fitzpatrick A, Ikram M, Destefano A, Gudnason V, Boada M, et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA. 2010;303:1832-40 pubmed publisher
    ..Two loci were identified to have genome-wide significance for the first time: rs744373 near BIN1 (odds ratio [OR],1.13; 95% confidence interval [CI],1.06-1.21 per copy of the minor allele; P = 1...
  6. Biffi A, Anderson C, Desikan R, Sabuncu M, Cortellini L, Schmansky N, et al. Genetic variation and neuroimaging measures in Alzheimer disease. Arch Neurol. 2010;67:677-85 pubmed publisher
    ..The GWAS-validated variants at the CR1 and PICALM loci and markers at 2 novel loci (BIN1 and CNTN5) showed association with multiple magnetic resonance imaging characteristics (false discovery rate P < ..
  7. Naj A, Jun G, Beecham G, Wang L, Vardarajan B, Buros J, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011;43:436-41 pubmed publisher
    ..6 × 10(-10), P(J) = 5.2 × 10(-11)), CLU (rs1532278; P(M) = 8.3 × 10(-8), P(J) = 1.9 × 10(-8)), BIN1 (rs7561528; P(M) = 4.0 × 10(-14), P(J) = 5.2 × 10(-14)) and PICALM (rs561655; P(M) = 7...
  8. Prokic I, Cowling B, Laporte J. Amphiphysin 2 (BIN1) in physiology and diseases. J Mol Med (Berl). 2014;92:453-63 pubmed publisher
    Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, has been recently implicated in rare and common diseases affecting different tissues and physiological functions...
  9. Spiegelhalter C, Tosch V, Hentsch D, Koch M, Kessler P, Schwab Y, et al. From dynamic live cell imaging to 3D ultrastructure: novel integrated methods for high pressure freezing and correlative light-electron microscopy. PLoS ONE. 2010;5:e9014 pubmed publisher
    ..phosphatase induced by osmotic stress, and of the ultrastructure of membrane tubules dependent on amphiphysin 2 (BIN1) expression...

More Information

Publications76

  1. Böhm J, Yis U, Ortac R, Cakmakci H, Kurul S, Dirik E, et al. Case report of intrafamilial variability in autosomal recessive centronuclear myopathy associated to a novel BIN1 stop mutation. Orphanet J Rare Dis. 2010;5:35 pubmed publisher
    ..recessive centronuclear myopathy (ARCNM) is less characterized and has recently been associated to mutations in BIN1, encoding amphiphysin 2...
  2. Leprince C, Le Scolan E, Meunier B, Fraisier V, Brandon N, de Gunzburg J, et al. Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking. J Cell Sci. 2003;116:1937-48 pubmed
    ..It could also play a role at the surface of the endocytic vesicle that has just been formed and of the future endosomes, in order to regulate intracellular trafficking. ..
  3. Lee E, Marcucci M, Daniell L, Pypaert M, Weisz O, Ochoa G, et al. Amphiphysin 2 (Bin1) and T-tubule biogenesis in muscle. Science. 2002;297:1193-6 pubmed
    ..These findings support a role of the bilayer-deforming properties of amphiphysin at T-tubules and, more generally, a physiological role of amphiphysin in membrane deformation...
  4. Wijsman E, Pankratz N, Choi Y, Rothstein J, Faber K, Cheng R, et al. Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE. PLoS Genet. 2011;7:e1001308 pubmed publisher
    ..There was evidence of association for recently-reported LOAD risk loci, including BIN1 (rs7561528, p?=?0.009 with, and p?=?0.03 without, APOE adjustment) and CLU (rs11136000, p?=?0.023 with, and p?=?0...
  5. Owen D, Wigge P, Vallis Y, Moore J, Evans P, McMahon H. Crystal structure of the amphiphysin-2 SH3 domain and its role in the prevention of dynamin ring formation. EMBO J. 1998;17:5273-85 pubmed
    ..To elucidate the nature of this interaction, we have solved the crystal structure of the amphiphysin-2 (Amph2) SH3 domain to 2.2 A...
  6. Tjondrokoesoemo A, Park K, Ferrante C, Komazaki S, Lesniak S, Brotto M, et al. Disrupted membrane structure and intracellular Ca²? signaling in adult skeletal muscle with acute knockdown of Bin1. PLoS ONE. 2011;6:e25740 pubmed publisher
    ..b>Bin1 consists of a specialized BAR domain that is associated with t-tubule development in skeletal muscle and involved ..
  7. Chapuis J, Hansmannel F, Gistelinck M, Mounier A, Van Cauwenberghe C, Kolen K, et al. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. Mol Psychiatry. 2013;18:1225-34 pubmed publisher
    Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene as the most important genetic susceptibility locus in Alzheimer's disease (AD) after APOE...
  8. Royer B, Hnia K, Gavriilidis C, Tronchère H, Tosch V, Laporte J. The myotubularin-amphiphysin 2 complex in membrane tubulation and centronuclear myopathies. EMBO Rep. 2013;14:907-15 pubmed publisher
    Myotubularin (MTM1) and amphiphysin 2 (BIN1) are two proteins mutated in different forms of centronuclear myopathy, but the functional and pathological relationship between these two proteins was unknown...
  9. Butler M, David C, Ochoa G, Freyberg Z, Daniell L, Grabs D, et al. Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brain and around T tubules in skeletal muscle. J Cell Biol. 1997;137:1355-67 pubmed
    ..We report here the characterization of a second mammalian amphiphysin gene, amphiphysin II (SH3P9; BIN1), which encodes products primarily expressed in skeletal muscle and brain, as differentially ..
  10. Carrasquillo M, Belbin O, Hunter T, Ma L, Bisceglio G, Zou F, et al. Replication of BIN1 association with Alzheimer's disease and evaluation of genetic interactions. J Alzheimers Dis. 2011;24:751-8 pubmed publisher
    ..LOAD) genome-wide association study revealed genome-wide significant association of two new loci: rs744373 near BIN1 (p = 1.6 × 10-11) and rs597668 near EXOC3L2/BLOC1S3/MARK4 (p = 6.5 × 10-9)...
  11. Hu X, Pickering E, Liu Y, Hall S, Fournier H, Katz E, et al. Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease. PLoS ONE. 2011;6:e16616 pubmed publisher
    ..on uncovering novel genetic loci related to AD have revealed associations with variants near CLU, CR1, PICALM and BIN1. In this study, we conducted a genome-wide association study in an independent set of 1034 cases and 1186 controls ..
  12. Fugier C, Klein A, Hammer C, Vassilopoulos S, Ivarsson Y, Toussaint A, et al. Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy. Nat Med. 2011;17:720-5 pubmed publisher
    ..We found that alternative splicing of the bridging integrator-1 (BIN1) pre-mRNA is altered in skeletal muscle samples of people with CDM1, DM1 and DM2...
  13. Lee J, Cheng R, Barral S, Reitz C, Medrano M, Lantigua R, et al. Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals. Arch Neurol. 2011;68:320-8 pubmed publisher
    ..We also replicated genetic associations for CLU, PICALM, and BIN1. Our genome-wide search of Caribbean Hispanic individuals identified several novel genetic variants associated with ..
  14. Toussaint A, Cowling B, Hnia K, Mohr M, Oldfors A, Schwab Y, et al. Defects in amphiphysin 2 (BIN1) and triads in several forms of centronuclear myopathies. Acta Neuropathol. 2011;121:253-66 pubmed publisher
    ..Genetically distinct forms exist, and mutations in BIN1 were recently identified in autosomal recessive cases (ARCNM)...
  15. Pan K, Liang X, Zhang H, Zhao J, Wang D, Li J, et al. Characterization of bridging integrator 1 (BIN1) as a potential tumor suppressor and prognostic marker in hepatocellular carcinoma. Mol Med. 2012;18:507-18 pubmed publisher
    It has been shown that bridging integrator 1 (BIN1) can interact with c-myelocytomatosis (c-Myc) oncoprotein in cancer. However, the role of BIN1 in hepatocellular carcinoma (HCC) is not clear...
  16. Claeys K, Maisonobe T, Bohm J, Laporte J, Hezode M, Romero N, et al. Phenotype of a patient with recessive centronuclear myopathy and a novel BIN1 mutation. Neurology. 2010;74:519-21 pubmed publisher
  17. Tan M, Yu J, Tan L. Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease. Trends Mol Med. 2013;19:594-603 pubmed publisher
    The bridging integrator 1 (BIN1) gene, also known as amphiphysin 2, has recently been identified as the most important risk locus for late onset Alzheimer's disease (LOAD), after apolipoprotein E (APOE)...
  18. Leprince C, Romero F, Cussac D, Vayssiere B, Berger R, Tavitian A, et al. A new member of the amphiphysin family connecting endocytosis and signal transduction pathways. J Biol Chem. 1997;272:15101-5 pubmed
    ..This hypothesis is strengthened by the ability of BRAMP2 to interact with the p21(ras) exchange factor SOS, in vitro, as a possible point of interconnection between the endocytic and signaling pathways. ..
  19. McMahon H, Wigge P, Smith C. Clathrin interacts specifically with amphiphysin and is displaced by dynamin. FEBS Lett. 1997;413:319-22 pubmed
    ..We have recently cloned a second amphiphysin isoform, Amph2 (sequence submitted to GenBank, Y13380)...
  20. Wigge P, Kohler K, Vallis Y, Doyle C, Owen D, Hunt S, et al. Amphiphysin heterodimers: potential role in clathrin-mediated endocytosis. Mol Biol Cell. 1997;8:2003-15 pubmed
    ..In a screen for novel members of the amphiphysin family, we identified Amph2, an isoform 49% identical to the previously characterized Amph1 protein...
  21. Wechsler Reya R, Sakamuro D, Zhang J, Duhadaway J, Prendergast G. Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing. J Biol Chem. 1997;272:31453-8 pubmed
    ..sequences that were included in brain-specific BIN1 species, also termed amphiphysin isoforms or amphiphysin II. The 5'-flanking region of BIN1 is GC-rich and lacks a TATA box but directs transcriptional initiation from a ..
  22. Casal E, Federici L, Zhang W, Fernandez Recio J, Priego E, Miguel R, et al. The crystal structure of the BAR domain from human Bin1/amphiphysin II and its implications for molecular recognition. Biochemistry. 2006;45:12917-28 pubmed
    ..Here, we report the crystal structure of the BAR domain from the human Bin1 protein at 2.0 A resolution...
  23. Mao N, Steingrimsson E, Duhadaway J, Wasserman W, Ruiz J, Copeland N, et al. The murine Bin1 gene functions early in myogenesis and defines a new region of synteny between mouse chromosome 18 and human chromosome 2. Genomics. 1999;56:51-8 pubmed
    We cloned and functionally characterized the murine Bin1 gene as a first step to investigate its physiological roles in differentiation, apoptosis, and tumorigenesis...
  24. Muller A, Baker J, DuHadaway J, Ge K, Farmer G, Donover P, et al. Targeted disruption of the murine Bin1/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation. Mol Cell Biol. 2003;23:4295-306 pubmed
    The mammalian Bin1/Amphiphysin II gene encodes an assortment of alternatively spliced adapter proteins that exhibit markedly divergent expression and subcellular localization profiles...
  25. Jungbluth H, Wallgren Pettersson C, Laporte J. Centronuclear (myotubular) myopathy. Orphanet J Rare Dis. 2008;3:26 pubmed publisher
    ..2 and the amphiphysin 2 (BIN1) gene on chromosome 2q14, respectively...
  26. Maeda Y, Tsutsui K, Seki S, Tokunaga A. cDNA cloning of a novel amphiphysin isoform and tissue-specific expression of its multiple splice variants. Biochem Biophys Res Commun. 1997;236:178-83 pubmed
    ..We have cloned cDNAs of a novel isoform of amphiphysin (amphiphysin II) by exploiting sequence information for homologous ESTs deposited in databases...
  27. Wechsler Reya R, Elliott K, Prendergast G. A role for the putative tumor suppressor Bin1 in muscle cell differentiation. Mol Cell Biol. 1998;18:566-75 pubmed
    b>Bin1 is a Myc-interacting protein with features of a tumor suppressor. The high level of Bin1 expression in skeletal muscle prompted us to investigate its role in muscle differentiation...
  28. Hollingworth P, Harold D, Sims R, Gerrish A, Lambert J, Carrasquillo M, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet. 2011;43:429-35 pubmed publisher
    ..6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10)). ..
  29. Ramjaun A, Micheva K, Bouchelet I, McPherson P. Identification and characterization of a nerve terminal-enriched amphiphysin isoform. J Biol Chem. 1997;272:16700-6 pubmed
    ..Here, we report the characterization of a novel amphiphysin isoform (termed amphiphysin II) that was identified through a homology search of the data base of expressed sequence tags...
  30. Sakamuro D, Elliott K, Wechsler Reya R, Prendergast G. BIN1 is a novel MYC-interacting protein with features of a tumour suppressor. Nat Genet. 1996;14:69-77 pubmed
    b>BIN1 is a novel protein that interacts with the functionally critical Myc box regions at the N terminus of the MYC oncoprotein...
  31. Ge K, Minhas F, Duhadaway J, Mao N, Wilson D, Buccafusca R, et al. Loss of heterozygosity and tumor suppressor activity of Bin1 in prostate carcinoma. Int J Cancer. 2000;86:155-61 pubmed
    ..b>Bin1 is a nucleocytoplasmic adaptor protein with features of a tumor suppressor that was identified through its ability ..
  32. Kojima C, Hashimoto A, Yabuta I, Hirose M, Hashimoto S, Kanaho Y, et al. Regulation of Bin1 SH3 domain binding by phosphoinositides. EMBO J. 2004;23:4413-22 pubmed
    b>Bin1/M-amphiphysin-II is an amphiphysin-II isoform highly expressed in transverse tubules of adult striated muscle and is implicated in their biogenesis...
  33. Pineda Lucena A, Ho C, Mao D, Sheng Y, Laister R, Muhandiram R, et al. A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants. J Mol Biol. 2005;351:182-94 pubmed
    The N terminus of the c-Myc oncoprotein interacts with Bin1, a ubiquitously expressed nucleocytoplasmic protein with features of a tumor suppressor...
  34. Pant S, Sharma M, Patel K, Caplan S, Carr C, Grant B. AMPH-1/Amphiphysin/Bin1 functions with RME-1/Ehd1 in endocytic recycling. Nat Cell Biol. 2009;11:1399-410 pubmed publisher
    ..Here we show that endogenous C. elegans AMPH-1, the only C. elegans member of the Amphiphysin/BIN1 family of BAR (Bin1-Amphiphysin-Rvs161p/167p)-domain-containing proteins, colocalizes with RME-1 on recycling ..
  35. Löw C, Weininger U, Lee H, Schweimer K, Neundorf I, Beck Sickinger A, et al. Structure and dynamics of helix-0 of the N-BAR domain in lipid micelles and bilayers. Biophys J. 2008;95:4315-23 pubmed publisher
    ..We determined the NMR structure and nano-to-picosecond dynamics of helix-0 of the human Bin1/Amphiphysin II BAR domain in sodium dodecyl sulfate and dodecylphosphocholine micelles...
  36. Zhang X, Yu J, Li J, Wang C, Tan L, Liu B, et al. Bridging Integrator 1 (BIN1) Genotype Effects on Working Memory, Hippocampal Volume, and Functional Connectivity in Young Healthy Individuals. Neuropsychopharmacology. 2015;40:1794-803 pubmed publisher
    ..The bridging integrator 1 (BIN1) gene has recently been identified in several large genome-wide association studies (GWAS) as the second most ..
  37. Sottejeau Y, Bretteville A, Cantrelle F, Malmanche N, Demiaute F, Mendes T, et al. Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain. Acta Neuropathol Commun. 2015;3:58 pubmed publisher
    ..We recently reported that the bridging integrator 1 (BIN1) risk gene is linked to Tau pathology...
  38. Bungenberg J, Surano N, Grote A, Surges R, Pernhorst K, Hofmann A, et al. Gene expression variance in hippocampal tissue of temporal lobe epilepsy patients corresponds to differential memory performance. Neurobiol Dis. 2016;86:121-30 pubmed publisher
    ..single nucleotide polymorphism rs744373 C-allele to be associated with high mRNA levels of bridging integrator 1 (BIN1)/Amphiphysin 2, i.e. a major component of the endocytotic machinery and located in a crucial genetic AD risk locus...
  39. Huang F, Shang Y, Luo Y, Wu P, Huang X, Tan X, et al. Lower Prevalence of Alzheimer's Disease among Tibetans: Association with Religious and Genetic Factors. J Alzheimers Dis. 2016;50:659-67 pubmed publisher
    ..MALDI-TOF was used to test the genotypes of CLU, TFAM, TP53INP1, IGHV1-67, CR1, ApoE, and BIN1. Logistic regression models were used to ascertain the associations with AD...
  40. Sassi C, Nalls M, Ridge P, Gibbs J, Ding J, Lupton M, et al. ABCA7 p.G215S as potential protective factor for Alzheimer's disease. Neurobiol Aging. 2016;46:235.e1-9 pubmed publisher
    ..of rare and low-frequency protein coding variants in 9 AD GWAS loci with the strongest effect sizes after APOE (BIN1, CLU, CR1, PICALM, MS4A6A, ABCA7, EPHA1, CD33, and CD2AP) in a cohort of 332 sporadic AD cases and 676 elderly ..
  41. Kouwenberg C, Böhm J, Erasmus C, van Balken I, Vos S, Kusters B, et al. Dominant Centronuclear Myopathy with Early Childhood Onset due to a Novel Mutation in BIN1. J Neuromuscul Dis. 2017;4:349-355 pubmed publisher
    Autosomal dominant centronuclear myopathy (CNM) caused by mutations in the gene coding for amphiphysin-2 (BIN1) typically presents in adulthood with progressive muscle weakness...
  42. Micheva K, Kay B, McPherson P. Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin. J Biol Chem. 1997;272:27239-45 pubmed
    ..These data demonstrate that synaptojanin is present in two separate complexes in the nerve terminal and support an important role for endophilin in the regulation of synaptojanin function. ..
  43. McKenna E, Tamayo P, Cho Y, Tillman E, Mora Blanco E, Sansam C, et al. Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumors. Cell Cycle. 2012;11:1956-65 pubmed publisher
    ..upon three independent SNF5-deficient cancer data sets from both human and mouse and identify downregulation of the BIN1 tumor suppressor as a conserved event in primary SNF5-deficient cancers...
  44. Sun L, Tan M, Hu N, Yu J, Tan L. Exploring the value of plasma BIN1 as a potential biomarker for alzheimer's disease. J Alzheimers Dis. 2013;37:291-5 pubmed publisher
    b>BIN1, as an important genetic susceptibility locus in late-onset Alzheimer's disease (AD), is overexpressed in AD brains...
  45. Papenberg G, Becker N, Ferencz B, Naveh Benjamin M, Laukka E, Backman L, et al. Dopamine Receptor Genes Modulate Associative Memory in Old Age. J Cogn Neurosci. 2017;29:245-253 pubmed publisher
    ..worse item and associative memory, indicating adverse effects of APOE ?4 and a genetic risk score for AD (PICALM, BIN1, CLU) on episodic memory in general...
  46. Ziegelbauer J, Wei J, Tjian R. Myc-interacting protein 1 target gene profile: a link to microtubules, extracellular signal-regulated kinase, and cell growth. Proc Natl Acad Sci U S A. 2004;101:458-63 pubmed
    ..Taken together, our studies suggest that MIZ-1 regulates a specific set of genes that includes LDLR and that the ERK pathway plays a role in the activation of target promoters by MIZ-1. ..
  47. Dräger N, Nachman E, Winterhoff M, Brühmann S, Shah P, Katsinelos T, et al. Bin1 directly remodels actin dynamics through its BAR domain. EMBO Rep. 2017;18:2051-2066 pubmed publisher
    ..Under physiological conditions, the N-BAR protein Bin1 has been shown to sense and curve membranes in a variety of cellular processes...
  48. Demonbreun A, Quattrocelli M, Barefield D, Allen M, Swanson K, McNally E. An actin-dependent annexin complex mediates plasma membrane repair in muscle. J Cell Biol. 2016;213:705-18 pubmed publisher
    ..Repair proteins, including dysferlin, EHD1, EHD2, MG53, and BIN1, localized adjacent to the repair cap in a "shoulder" region enriched with phosphatidlyserine...
  49. Daum B, Auerswald A, Gruber T, Hause G, Balbach J, Kühlbrandt W, et al. Supramolecular organization of the human N-BAR domain in shaping the sarcolemma membrane. J Struct Biol. 2016;194:375-82 pubmed publisher
    The 30kDa N-BAR domain of the human Bin1 protein is essential for the generation of skeletal muscle T-tubules...
  50. KINNEY E, Tanida S, Rodrigue A, Johnson J, Tompkins V, Sakamuro D. Adenovirus E1A oncoprotein liberates c-Myc activity to promote cell proliferation through abating Bin1 expression via an Rb/E2F1-dependent mechanism. J Cell Physiol. 2008;216:621-31 pubmed publisher
    ..Conversely, the c-Myc oncoprotein-binding tumor suppressor, Bin1, inhibits Ras/E1A-mediated cell transformation...
  51. Malki I, Cantrelle F, Sottejeau Y, Lippens G, Lambert J, Landrieu I. Regulation of the interaction between the neuronal BIN1 isoform 1 and Tau proteins - role of the SH3 domain. FEBS J. 2017;284:3218-3229 pubmed publisher
    Bridging integrator 1 (bin1) gene is a genetic determinant of Alzheimer's disease (AD) and has been reported to modulate Alzheimer's pathogenesis through pathway(s) involving Tau...
  52. Chan W, Tian R, Lee Y, Sit S, Lim L, Manser E. Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2. J Biol Chem. 2009;284:8185-94 pubmed publisher
    ..These processes are particularly pertinent given the report of genomic amplification of the ACK1 locus in metastatic tumors. ..
  53. Myers M, Ryazantsev S, Hicke L, Payne G. Calmodulin Promotes N-BAR Domain-Mediated Membrane Constriction and Endocytosis. Dev Cell. 2016;37:162-73 pubmed publisher
    ..These studies reveal a conserved role for calmodulin in regulating the intrinsic membrane-sculpting activity of endocytic N-BAR domains. ..
  54. Wang H, Wan Y, Hao X, Cao L, Zhu X, Jiang T, et al. Bridging Integrator 1 (BIN1) Genotypes Mediate Alzheimer's Disease Risk by Altering Neuronal Degeneration. J Alzheimers Dis. 2016;52:179-90 pubmed publisher
    Bridging integrator 1 (BIN1) has been identified as one of the most associated loci for Alzheimer's disease (AD), and recently was reported to modulate tau pathology to mediate AD in vitro...
  55. Kaya G, Gündüz E, Acar M, HatipoÄŸlu Ã, Acar B, Ilhan A, et al. Potential genetic biomarkers in the early diagnosis of Alzheimer disease: APOE and BIN1. Turk J Med Sci. 2015;45:1058-72 pubmed
    ..According to genome-wide association studies, the BIN1 gene is the second important risk factor for AD, following the APOE gene...
  56. D Alessandro M, Hnia K, Gache V, Koch C, Gavriilidis C, Rodriguez D, et al. Amphiphysin 2 Orchestrates Nucleus Positioning and Shape by Linking the Nuclear Envelope to the Actin and Microtubule Cytoskeleton. Dev Cell. 2015;35:186-98 pubmed publisher
    ..and organ development and is affected in many diseases, including myopathies due to alteration in amphiphysin-2 (BIN1)...
  57. Zhou Y, Hayashi I, Wong J, Tugusheva K, Renger J, Zerbinatti C. Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease. PLoS ONE. 2014;9:e103187 pubmed publisher
    ..additional single nucleotide polymorphisms (SNPs) linked to AD susceptibility, including those in the CLU and BIN1 genes encoding for clusterin (CLU) and the bridging integrator 1 (BIN1) proteins, respectively...
  58. Aladag A, Hoffmann S, Stoldt M, Bösing C, Willbold D, Schwarten M. Hepatitis C virus NS5A is able to competitively displace c-Myc from the Bin1 SH3 domain in vitro. J Pept Sci. 2014;20:334-40 pubmed publisher
    We studied the interaction of the SH3 domain of Bin1 with a 15-mer peptide of HCV NS5A and show its potency to competitively displace a 15-mer human c-Myc fragment, which is a physiological ligand of Bin1, using NMR spectroscopy...
  59. Tan M, Yu J, Jiang T, Zhu X, Guan H, Tan L. Genetic variation in BIN1 gene and Alzheimer's disease risk in Han Chinese individuals. Neurobiol Aging. 2014;35:1781.e1-8 pubmed publisher
    Genome-wide association studies have identified the bridging integrator 1 (BIN1) gene as the most important genetic susceptibility locus in late-onset Alzheimer's disease (LOAD) after apolipoprotein E for individuals of European ancestry...
  60. Ganesan S. MYC, PARP1, and chemoresistance: BIN there, done that?. Sci Signal. 2011;4:pe15 pubmed publisher
    ..The adaptor protein BIN1, whose expression is regulated by c-MYC, interacts with PARP1 and inhibits its enzymatic activity...
  61. Lundgaard G, Daniels N, Pyndiah S, Cassimere E, Ahmed K, Rodrigue A, et al. Identification of a novel effector domain of BIN1 for cancer suppression. J Cell Biochem. 2011;112:2992-3001 pubmed publisher
    Bridging integrator 1 (BIN1) is a nucleocytoplasmic adaptor protein with tumor suppressor properties. The protein interacts with and inhibits the c-MYC transcription factor through the BIN1 MYC-binding domain (MBD)...
  62. Kamboh M, Demirci F, Wang X, Minster R, Carrasquillo M, Pankratz V, et al. Genome-wide association study of Alzheimer's disease. Transl Psychiatry. 2012;2:e117 pubmed publisher
    ..E (APOE), recent large genome-wide association studies (GWASs) have identified nine other genes/loci (CR1, BIN1, CLU, PICALM, MS4A4/MS4A6E, CD2AP, CD33, EPHA1 and ABCA7) for late-onset Alzheimer's disease (LOAD)...
  63. Ralser M, Nonhoff U, Albrecht M, Lengauer T, Wanker E, Lehrach H, et al. Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways. Hum Mol Genet. 2005;14:2893-909 pubmed
    ..Thus, our findings suggest an interplay between ataxin-2, endophilin proteins and huntingtin in plastin-associated cellular pathways. ..
  64. Ghaneie A, Zemba Palko V, Itoh H, Itoh K, Sakamuro D, Nakamura S, et al. Bin1 attenuation in breast cancer is correlated to nodal metastasis and reduced survival. Cancer Biol Ther. 2007;6:192-4 pubmed
    ..The Bin1 gene encodes a nucleocytosolic adapter protein that suppresses neoplastic cell transformation and that is often ..
  65. Kajiho H, Saito K, Tsujita K, Kontani K, Araki Y, Kurosu H, et al. RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway. J Cell Sci. 2003;116:4159-68 pubmed
    ..RIN3 was also capable of interacting via its Pro-rich domain with amphiphysin II, which contains SH3 domain and participates in receptor-mediated endocytosis...
  66. Elliott K, Sakamuro D, Basu A, Du W, Wunner W, Staller P, et al. Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms. Oncogene. 1999;18:3564-73 pubmed
    The tumor suppressor Bin1 was identified through its interaction with the N-terminal region of Myc which harbors its transcriptional activation domain...
  67. Barral S, Bird T, Goate A, Farlow M, Diaz Arrastia R, Bennett D, et al. Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory. Neurology. 2012;78:1464-71 pubmed publisher
    ..Disease Family Study, we conducted a family-based association study in which we tabulated MLGPs for SNPs at CR1, BIN1, CLU, PICALM, and APOE...