BIK

Summary

Gene Symbol: BIK
Description: BCL2 interacting killer
Alias: BIP1, BP4, NBK, bcl-2-interacting killer, BCL2-interacting killer (apoptosis-inducing), apoptosis inducer NBK, apoptosis-inducing NBK, natural born killer
Species: human
Products:     BIK

Top Publications

  1. Zou Y, Peng H, Zhou B, Wen Y, Wang S, Tsai E, et al. Systemic tumor suppression by the proapoptotic gene bik. Cancer Res. 2002;62:8-12 pubmed
    ..therapy approach for breast cancer, consisting of a nonviral gene delivery system (SN) and a proapoptotic gene, bik. The transfection efficiency of SN carrying a reporter gene was 5-10 times higher than the common nonviral agents ..
  2. Han J, Sabbatini P, White E. Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K. Mol Cell Biol. 1996;16:5857-64 pubmed
    ..Like Bax and Bak, Nbk was cloned from a yeast two-hybrid screen for proteins that interact with E1B 19K...
  3. Germain M, Mathai J, Shore G. BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria. J Biol Chem. 2002;277:18053-60 pubmed
    ..Stimulation of apoptosis by p53 is accompanied by induction of the BH-3-only proapoptotic member of the BCL-2 family, BIK, and ectopic expression of BIK in p53-null cells caused the release of cytochrome c from mitochondria and ..
  4. Gillissen B, Essmann F, Graupner V, Stärck L, Radetzki S, Dorken B, et al. Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. EMBO J. 2003;22:3580-90 pubmed
    Nbk/Bik (natural born killer/Bcl-2-interacting killer) is a tissue-specific BH3-only protein whose molecular function is still largely unknown...
  5. Certo M, Del Gaizo Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong S, et al. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell. 2006;9:351-65 pubmed
    ..Our data allow us to distinguish a cellular state we call "primed for death," which can be determined by BH3 profiling and which correlates with dependence on antiapoptotic family members for survival. ..
  6. Boyd J, Gallo G, Elangovan B, Houghton A, Malstrom S, Avery B, et al. Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. Oncogene. 1995;11:1921-8 pubmed
    ..We have identified a novel cellular protein, Bik, that interacts with the cellular survival-promoting proteins, Bcl-2 and Bcl-xL, as well as the viral survival-..
  7. Verma S, Budarf M, Emanuel B, Chinnadurai G. Structural analysis of the human pro-apoptotic gene Bik: chromosomal localization, genomic organization and localization of promoter sequences. Gene. 2000;254:157-62 pubmed
    The human Bik gene codes for a strong pro-apoptotic protein BIK. We have used fluorescent in-situ hybridization to establish the chromosomal localization of the Bik gene to 22q13.3...
  8. Chen L, Willis S, Wei A, Smith B, Fletcher J, Hinds M, et al. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell. 2005;17:393-403 pubmed
    ..The results suggest that apoptosis relies on selective interactions between particular subsets of these proteins and that it should be feasible to discover BH3-mimetic drugs that inactivate specific prosurvival targets. ..
  9. Lopez J, Hesling C, Prudent J, Popgeorgiev N, Gadet R, Mikaelian I, et al. Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik. Cell Death Differ. 2012;19:1459-69 pubmed publisher
    ..the mitochondrial pathway of apoptosis by specifically increasing the degradation rate of the BH3-only protein Bik. This effect relies on the activation of the Ras-Raf-Mek1/2-Erk1/2 pathway, and on the phosphorylation of Bik on ..

More Information

Publications147 found, 100 shown here

  1. Arena V, Martini M, Luongo M, Capelli A, Larocca L. Mutations of the BIK gene in human peripheral B-cell lymphomas. Genes Chromosomes Cancer. 2003;38:91-6 pubmed
    b>BIK, a BH (Bcl2 homology domain)3-only protein, is a proapoptotic member of the BCL2 family...
  2. Kuwana T, Bouchier Hayes L, Chipuk J, Bonzon C, Sullivan B, Green D, et al. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell. 2005;17:525-35 pubmed
    ..In this model, the simple inhibition of antiapoptotic functions is insufficient to induce apoptosis unless a direct activator of Bax or Bak is present. ..
  3. Wu J, Chen Z, Liu Q, Zeng W, Wu X, Lin B. Silencing of Kv1.5 Gene Inhibits Proliferation and Induces Apoptosis of Osteosarcoma Cells. Int J Mol Sci. 2015;16:26914-26 pubmed publisher
    ..of p21, p27, Bax, Bcl-XL and caspase-3 and down-regulation of cyclins A, cyclins D1, cyclins E, Bcl-2 and Bik. In summary, our results indicate that Kv1...
  4. Choi Y, Yoon S, Byun Y, Lee G, Kee H, Jeong Y, et al. MicroRNA library screening identifies growth-suppressive microRNAs that regulate genes involved in cell cycle progression and apoptosis. Exp Cell Res. 2015;339:320-32 pubmed publisher
    ..specificity protein 1 (SP1), and phosphorylated Akt were all downregulated, while Bcl-2-interacting killer (BIK) was upregulated...
  5. Jacouton E, Chain F, Sokol H, Langella P, Bermúdez Humarán L. Probiotic Strain Lactobacillus casei BL23 Prevents Colitis-Associated Colorectal Cancer. Front Immunol. 2017;8:1553 pubmed publisher
    ..cytokine, and an antiproliferative effect, mediated through the upregulation of caspase-7, caspase-9, and Bik. Finally, L...
  6. Rabenhorst U, Beinoraviciute Kellner R, Brezniceanu M, Joos S, Devens F, Lichter P, et al. Overexpression of the far upstream element binding protein 1 in hepatocellular carcinoma is required for tumor growth. Hepatology. 2009;50:1121-9 pubmed publisher
    ..proapoptotic genes tumor necrosis factor alpha, tumor necrosis factor-related apoptosis-inducing ligand, Noxa, and Bik were elevated in the absence of FBP1...
  7. Gorbatyuk M, Knox T, Lavail M, Gorbatyuk O, Noorwez S, Hauswirth W, et al. Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78. Proc Natl Acad Sci U S A. 2010;107:5961-6 pubmed publisher
    ..We detected complexes between BiP, caspase-12, and the BH3-only protein BiK that may contribute to the antiapoptotic activity of BiP...
  8. Tibullo D, Giallongo C, Puglisi F, Tomassoni D, Camiolo G, Cristaldi M, et al. Effect of Lipoic Acid on the Biochemical Mechanisms of Resistance to Bortezomib in SH-SY5Y Neuroblastoma Cells. Mol Neurobiol. 2018;55:3344-3350 pubmed publisher
    ..Similarly, ALA significantly reduced BTZ-mediated endoplasmic reticulum stress as measured by reduction in BiP1 and IRE1α, ERO1α, and PDI expression...
  9. Waye S, Naeem A, Choudhry M, Parasido E, Tricoli L, Sivakumar A, et al. The p53 tumor suppressor protein protects against chemotherapeutic stress and apoptosis in human medulloblastoma cells. Aging (Albany NY). 2015;7:854-68 pubmed
    ..DNA fragmentation and increased expression of genes involved in apoptosis, including CAPN12 and TRPM8, p63, p73, BIK, EndoG, CIDEB, P27Kip1 and P21cip1...
  10. Hussain S, George S, Singh S, Jayant R, Hu C, Sopori M, et al. A Small Molecule BH3-mimetic Suppresses Cigarette Smoke-Induced Mucous Expression in Airway Epithelial Cells. Sci Rep. 2018;8:13796 pubmed publisher
    ..mucus expression and disrupted the EGFR-signaling while inducing the apoptosis and the pro-apoptotic protein, Bik expression...
  11. Guo J, Guan P, Ding W, Wang S, Huang X, Wang Z, et al. Erythrocyte membrane-encapsulated celecoxib improves the cognitive decline of Alzheimer's disease by concurrently inducing neurogenesis and reducing apoptosis in APP/PS1 transgenic mice. Biomaterials. 2017;145:106-127 pubmed publisher
    ..the expression of SOD2 and 14-3-3?, and PGD2 stimulated apoptosis by increasing the expression of BIK and decreasing the expression of ARRB1...
  12. Pilinska M, Dybsky S, Dybska O, Shvayko L, Sushko V. Peculiarities of induction and persistence of hidden chromosome instability in peripheral blood lymphocytes of persons occupationally exposed to ionizing radiation. Probl Radiac Med Radiobiol. 2014;19:321-33 pubmed
    ..pry riznyh strokah kul'tyvuvannja limfocytiv profesijna grupa virogidno vidriznjalys' vid grupy porivnjannja v bik zrostannja pokaznykiv hromosomnoi' nestabil'nosti z suttjevymy mizhindyvidual'nymy kolyvannjamy. Vysnovok...
  13. Wang Y, Luo Z, Pan Y, Wang W, Zhou X, Jeong L, et al. Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells. Cancer Biol Ther. 2015;16:420-9 pubmed publisher
    ..apoptosis was mediated by intrinsic apoptotic signaling with substantial up-regulation of pro-apoptotic Bik and Noxa as well as down-regulation of anti-apoptotic XIAP, c-IAP1 and c-IAP2, while senescence induction upon ..
  14. Mondal B, Shim J, Evans C, Banerjee U. Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors. elife. 2014;3:e03626 pubmed publisher
    ..maintenance, particularly those involved in equilibrium signaling, we performed a genetic screen that identified bip1 (bric à brac interacting protein 1) and Nucleoporin 98 (Nup98) as additional regulators of the equilibrium ..
  15. Laporte A, Barrott J, Yao R, Poulin N, Brodin B, Jones K, et al. HDAC and Proteasome Inhibitors Synergize to Activate Pro-Apoptotic Factors in Synovial Sarcoma. PLoS ONE. 2017;12:e0169407 pubmed publisher
    ..treatment leads to elevated endoplasmic reticulum stress, activation of pro-apoptotic effector proteins BIM and BIK, phosphorylation of BCL-2, increased levels of reactive oxygen species, and suppression of tumor growth in a murine ..
  16. Fialkova V, Vidomanová E, Balharek T, Marcinek J, Kudela E, Hányšová S, et al. DNA methylation as mechanism of apoptotic resistance development in endometrial cancer patients. Gen Physiol Biophys. 2017;36:521-529 pubmed publisher
    ..001), CIDEB (p < 0.03) and GADD45A (p < 0.05) during endometrial carcinogenesis and BIK gene (p < 0.03) in different phases of normal menstrual cycle...
  17. Mazmanian G, Kovshilovsky M, Yen D, Mohanty A, Mohanty S, Nee A, et al. The zebrafish dyrk1b gene is important for endoderm formation. Genesis. 2010;48:20-30 pubmed publisher
    ..revealed modestly expanded expression of the dorsal axial mesoderm marker gsc while the pan-mesodermal marker bik was largely unaffected. The endodermal markers cas and sox17 were also moderately reduced in dyrk1b-MO animals...
  18. Clarke R, Shajahan A, Wang Y, Tyson J, Riggins R, Weiner L, et al. Endoplasmic reticulum stress, the unfolded protein response, and gene network modeling in antiestrogen resistant breast cancer. Horm Mol Biol Clin Investig. 2011;5:35-44 pubmed
    ..The XBP1 subnetwork topology incorporates BCAR3, BCL2, BIK, NFκB, and other genes as nodes; the connecting edges represent the dependency structures amongst these nodes...
  19. Guan H, Xie L, Wirth T, Ushmorov A. Repression of TCF3/E2A contributes to Hodgkin lymphomagenesis. Oncotarget. 2016;7:36854-36864 pubmed publisher
    ..Mechanistically, TCF3 overexpression modulated expression of multiple pro-apoptotic genes including BIK, APAF1, FASLG, BOK, and TNFRSF10A/DR4...
  20. Cheng Q, Wu L, Tu R, Wu J, Kang W, Su T, et al. Mycoplasma fermentans deacetylase promotes mammalian cell stress tolerance. Microbiol Res. 2017;201:1-11 pubmed publisher
    ..deacetylase is involved in cellular anti-oxidation, which correlates with changes in the proapoptotic proteins BIK, p21 and BIM...
  21. Wittmann J, Klumpp J, Moreno Switt A, Yagubi A, Ackermann H, Wiedmann M, et al. Taxonomic reassessment of N4-like viruses using comparative genomics and proteomics suggests a new subfamily - "Enquartavirinae". Arch Virol. 2015;160:3053-62 pubmed publisher
    ..to create four new genera: "G7cvirus" (consisting of phages G7C, IME11, KBNP21, vB_EcoP_PhAPEC5, vB_EcoP_PhAPEC7, Bp4, EC1-UPM and pSb-1), "Lit1virus" (LIT1, PA26 and vB_PaeP_C2-10_Ab09), "Sp58virus" (SP058 and SP076), and "Dss3virus"..
  22. Subramanian T, Vijayalingam S, Kuppuswamy M, Chinnadurai G. Interaction of cellular proteins with BCL-xL targeted to cytoplasmic inclusion bodies in adenovirus infected cells. Virology. 2015;483:21-31 pubmed publisher
    ..These proteins included BAX, BAK, BID, BIK and BIM as well as mitochondrial proteins such as prohibitin 2, ATP synthase and DNA-PKcs...
  23. Maxfield K, Taus P, Corcoran K, Wooten J, Macion J, Zhou Y, et al. Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer. Nat Commun. 2015;6:8840 pubmed publisher
    ..FATE1 prevents the accumulation of the stress-sensing BH3-only protein, BCL-2-Interacting Killer (BIK), thereby permitting viability in the presence of toxic stimuli...
  24. Deutsch A, Rinner B, Pichler M, Prochazka K, Pansy K, Bischof M, et al. NR4A3 Suppresses Lymphomagenesis through Induction of Proapoptotic Genes. Cancer Res. 2017;77:2375-2386 pubmed publisher
    ..lines overexpressing either NR4A3 or NR4A1 revealed that apoptosis was driven similarly by induction of BAK, Puma, BIK, BIM, BID, and Trail...
  25. Li B, Gao T. Functional Role of Mitochondrial and Nuclear BK Channels. Int Rev Neurobiol. 2016;128:163-91 pubmed publisher
    ..release is well established; however, the composition and functions of mitochondrial and nuclear BK (nBK) channels are largely unknown...
  26. Zaanan A, Okamoto K, Kawakami H, Khazaie K, Huang S, Sinicrope F. The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism. J Biol Chem. 2015;290:23838-49 pubmed publisher
    ..Despite BIM and BIK induction, the isogenic KRAS mutant versus wild-type cells remained resistant to GDC-0623-induced apoptosis, in ..
  27. Huang Y, Luo L, Ma X, Wang X. Effect of elevated benzophenone-4 (BP4) concentration on Chlorella vulgaris growth and cellular metabolisms. Environ Sci Pollut Res Int. 2018;25:32549-32561 pubmed publisher
    Benzophenone-4 (BP4), as the raw material of common sunscreen products, usually shows strong eco-toxicity and endocrine-disrupting activity in aquatic animals...
  28. Loviglio M, Leleu M, Männik K, Passeggeri M, Giannuzzi G, van der Werf I, et al. Chromosomal contacts connect loci associated with autism, BMI and head circumference phenotypes. Mol Psychiatry. 2017;22:836-849 pubmed publisher
    ..Such phenotypes were previously associated with rearrangements of the non-overlapping proximal 16p11.2 600?kb BP4-BP5 interval. These two CNV-prone regions at 16p11...
  29. Singh S, Chand H, Gundavarapu S, Saeed A, Langley R, Tesfaigzi Y, et al. HIF-1α Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice. PLoS ONE. 2015;10:e0137757 pubmed publisher
    ..was associated with increased alveolar volumes, higher levels of proapoptotic factors (FOXO3a, HIPK2, p53, BIM, BIK, and BAX) and the antiangiogenic factor (GAX), and lower levels of antiapoptotic factors (Akt-PI3K, NF-κB, HIF-1..
  30. Zhang L, Li X, Chao Y, He R, Liu J, Yuan Y, et al. KLF4, a miR-32-5p targeted gene, promotes cisplatin-induced apoptosis by upregulating BIK expression in prostate cancer. Cell Commun Signal. 2018;16:53 pubmed publisher
    ..Further mechanistic studies revealed that KLF4 directly bound to the promoter of BIK, facilitating its transcription...
  31. Sun Y, Ponz Sarvisé M, Chang S, Chang W, Chen C, Hsu J, et al. Proteasome inhibition enhances the killing effect of BikDD gene therapy. Am J Transl Res. 2015;7:319-27 pubmed
    BikDD, a phosphorylation-mimic mutant of pro-apoptotic protein Bik, elicits strong apoptosis in cancer cells when introduced via an expression platform termed VP16-GAL4-WPRE integrated systemic amplifier (VISA) under the control of a ..
  32. Zhao X, Wang L, Sun Y, Ye L, Lu J, Yuan Y, et al. The endoplasmic reticulum (ER)-target protein Bik induces Hep3B cells apoptosis by the depletion of the ER Ca2+ stores. Mol Cell Biochem. 2008;312:33-8 pubmed publisher
    b>Bik, a BH3-only protein, was identified to induce cells apoptosis. In this study, we reported that Bik exclusively localized to endoplasmic reticulum rather than mitochondria...
  33. Boumela I, Assou S, Haouzi D, Dechaud H, Ait Ahmed O, Hamamah S. Developmental regulated expression of anti- and pro-apoptotic BCL-2 family genes during human early embryonic development. Curr Med Chem. 2014;21:1361-9 pubmed
    ..family transcripts, such as BCL2L10, to embryo-produced transcripts after embryonic genome activation, including BIK, BCL2L11 and NOXA...
  34. Aweya J, Sze C, Bayega A, Mohd Ismail N, Deng L, Hotta H, et al. NS5B induces up-regulation of the BH3-only protein, BIK, essential for the hepatitis C virus RNA replication and viral release. Virology. 2015;474:41-51 pubmed publisher
    ..genes that are dysregulated during HCV infection, of which the BH3-only pro-apoptotic Bcl-2 family protein, BIK, was consistently up-regulated at the mRNA and protein levels...
  35. Okamoto K, Zaanan A, Kawakami H, Huang S, Sinicrope F. Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells. Mol Cancer Res. 2015;13:659-69 pubmed publisher
    ..inhibitor, carfilzomib, was evaluated and found to potently induce Noxa, which was dependent upon c-Myc, and Bik. Isogenic mutant versus wild-type KRAS carcinoma cells showed elevated Bcl-xL, confirmed by KRAS siRNA or ectopic ..
  36. Inoue R, Watanabe K, Katou T, Ikezawa Y, Hamasaki K. Nucleobase modified neamines with a lysine as a linker, their inhibition specificity for TAR-Tat derived from HIV-1. Bioorg Med Chem. 2015;23:2139-47 pubmed publisher
    Nucleobase modified neamines with a lysine as the linker (NbK-neamines) were synthesized and their binding toward hairpin RNAs derived from HIV-1 activator region were studied...
  37. Gill R, Chen Q, D Angelo D, Chung W. Eating in the absence of hunger but not loss of control behaviors are associated with 16p11.2 deletions. Obesity (Silver Spring). 2014;22:2625-31 pubmed publisher
    The ∼600-kb BP4-BP5 16p11.2 deletion has been consistently associated with obesity...
  38. Castronovo C, Crippa M, Bestetti I, Rusconi D, Russo S, Larizza L, et al. Complex de novo chromosomal rearrangement at 15q11-q13 involving an intrachromosomal triplication in a patient with a severe neuropsychological phenotype: clinical report and review of the literature. Am J Med Genet A. 2015;167A:221-30 pubmed publisher
    ..2 (between low-copy repeats BP1 and BP2), and a heterozygous triplication of 6.8 Mb at 15q11.2-q13.1 (BP2-BP4). Both acquisitions were de novo and contiguous...
  39. Sindhu R, Manonmani H. l-asparaginase induces intrinsic mitochondrial-mediated apoptosis in human gastric adenocarcinoma cells and impedes tumor progression. Biochem Biophys Res Commun. 2018;503:2393-2399 pubmed publisher
    ..The RT-PCR analysis of pro-apoptosis genes: bak1, bax, bbc3, bik, pmaip1, bnip3l, apaf1, casp3, casp7 and casp9 were significantly higher (P < 0...
  40. Andreu Fernández V, Garcia Murria M, Bañó Polo M, Martin J, Monticelli L, Orzáez M, et al. The C-terminal Domains of Apoptotic BH3-only Proteins Mediate Their Insertion into Distinct Biological Membranes. J Biol Chem. 2016;291:25207-25216 pubmed
    ..vitro expression system to study the insertion capacity of hydrophobic C-terminal regions of the BH3-only proteins Bik, Bim, Noxa, Bmf, and Puma into microsomal membranes...
  41. Campbell S, Carlson K, Buchholz C, Helmers M, Ghosh I. Mapping the BH3 Binding Interface of Bcl-xL, Bcl-2, and Mcl-1 Using Split-Luciferase Reassembly. Biochemistry. 2015;54:2632-43 pubmed publisher
    ..three receptors, Bcl-xL, Bcl-2, and Mcl-1, and interrogated them against BH3 helices derived from Bad, Bak, Bid, Bik, Bim, Bmf, Hrk, and Puma...
  42. Duroux Richard I, Roubert C, Ammari M, Presumey J, Grün J, Häupl T, et al. miR-125b controls monocyte adaptation to inflammation through mitochondrial metabolism and dynamics. Blood. 2016;128:3125-3136 pubmed publisher
    ..miR-125b) attenuates the mitochondrial respiration through the silencing of the BH3-only proapoptotic protein BIK and promotes the elongation of the mitochondrial network through the targeting of the mitochondrial fission process ..
  43. Campion E, Hakimjavadi R, Loughran S, Phelan S, Smith S, D Souza B, et al. Repression of the proapoptotic cellular BIK/NBK gene by Epstein-Barr virus antagonizes transforming growth factor ?1-induced B-cell apoptosis. J Virol. 2014;88:5001-13 pubmed publisher
    ..Here, we show that BIK (also known as NBK), which encodes a proapoptotic "sensitizer" protein, is repressed by the EBNA2-driven ..
  44. Nykänen M, Birch D, Peterson R, Yu H, Kautto L, Gryshyna A, et al. Ultrastructural features of the early secretory pathway in Trichoderma reesei. Curr Genet. 2016;62:455-65 pubmed publisher
    ..QM6a, cellulase-overexpressing Rut-C30 strain and a Rut-C30 transformant BV47 overexpressing a recombinant BiP1-VenusYFP fusion protein with an endoplasmic reticulum (ER) retention signal...
  45. Jelinek M, Kabelova A, Srámek J, Seitz J, Ojima I, Kovar J. Differing Mechanisms of Death Induction by Fluorinated Taxane SB-T-12854 in Breast Cancer Cells. Anticancer Res. 2017;37:1581-1590 pubmed
    ..Anti-apoptotic Bcl-2 and pro-apoptotic Bim, Bok, Bid and Bik seem to be also associated with cell death induction in some of the tested cells...
  46. Ji J, Zhou B, Zhang R, Li H, Guo Q, Zhu J, et al. MG-132 treatment promotes TRAIL-mediated apoptosis in SEB-1 sebocytes. Life Sci. 2018;210:150-157 pubmed publisher
    ..Additionally, RNA interfering was used to knockdown the mRNA transcription of TRAIL and BIK gene. MG-132 treatment enhanced cell death in SEB-1 sebocytes but not in HaCaT keratinocytes...
  47. Miller D, Shen Y, Weiss L, Korn J, Anselm I, Bridgemohan C, et al. Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disorders. J Med Genet. 2009;46:242-8 pubmed publisher
    Segmental duplications at breakpoints (BP4-BP5) of chromosome 15q13.2q13.3 mediate a recurrent genomic imbalance syndrome associated with mental retardation, epilepsy, and/or electroencephalogram (EEG) abnormalities...
  48. Jenkins J, Chow V, Blaskey L, Kuschner E, Qasmieh S, Gaetz L, et al. Auditory Evoked M100 Response Latency is Delayed in Children with 16p11.2 Deletion but not 16p11.2 Duplication. Cereb Cortex. 2016;26:1957-64 pubmed publisher
    Individuals with the 16p11.2 BP4-BP5 copy number variant (CNV) exhibit a range of behavioral phenotypes that may include mild impairment in cognition and clinical diagnoses of autism spectrum disorder (ASD)...
  49. Alkhomashi N, Monged M. Long-term assessment of contaminated articles from the Chernobyl reactor. J Environ Radioact. 2015;144:52-6 pubmed publisher
    ..a sample of this contaminated clothing 20 years after the accident using three different detectors, namely, a BP4/4C scintillation detector, a Min-Con Geiger-Müller tube detector and a high-purity germanium (HPGe) detector...
  50. Arbogast T, Ouagazzal A, Chevalier C, Kopanitsa M, Afinowi N, Migliavacca E, et al. Reciprocal Effects on Neurocognitive and Metabolic Phenotypes in Mouse Models of 16p11.2 Deletion and Duplication Syndromes. PLoS Genet. 2016;12:e1005709 pubmed publisher
    The 16p11.2 600 kb BP4-BP5 deletion and duplication syndromes have been associated with developmental delay; autism spectrum disorders; and reciprocal effects on the body mass index, head circumference and brain volumes...
  51. Borst A, Haferkamp S, Grimm J, Rösch M, Zhu G, Guo S, et al. BIK is involved in BRAF/MEK inhibitor induced apoptosis in melanoma cell lines. Cancer Lett. 2017;404:70-78 pubmed publisher
    ..Screening for differentially expressed apoptosis-related genes revealed loss of BCL2-Interacting Killer (BIK) mRNA in CCA-cells...
  52. Loviglio M, Arbogast T, Jønch A, Collins S, Popadin K, Bonnet C, et al. The Immune Signaling Adaptor LAT Contributes to the Neuroanatomical Phenotype of 16p11.2 BP2-BP3 CNVs. Am J Hum Genet. 2017;101:564-577 pubmed publisher
    Copy-number changes in 16p11.2 contribute significantly to neuropsychiatric traits. Besides the 600 kb BP4-BP5 CNV found in 0...
  53. De Prins M, Verheyen E, Kerkhofs S, Hoffmann A, Vanbutsele G, Sree S, et al. EU-7 zeolite: a synthetic BIK type zeolite with high hydrothermal stability. Chem Commun (Camb). 2018;: pubmed publisher
    EU-7 zeolite with Si/Al ratio of 15 is identified as a BIK type zeolite. The framework charge is compensated with Cs+ cations located in 8-ring channels at regular distances...
  54. Green Snyder L, D Angelo D, Chen Q, Bernier R, Goin Kochel R, Wallace A, et al. Autism Spectrum Disorder, Developmental and Psychiatric Features in 16p11.2 Duplication. J Autism Dev Disord. 2016;46:2734-48 pubmed publisher
    The 16p11.2 duplication (BP4-BP5) is associated with Autism Spectrum Disorder (ASD), although significant heterogeneity exists...
  55. Peng M, Du E, Li Z, Li D, Li H. Transformation and toxicity assessment of two UV filters using UV/H2O2 process. Sci Total Environ. 2017;603-604:361-369 pubmed publisher
    The treatment of two typical UV filters benzophenone-4 (BP4) and benzophenone-9 (BP9) was evaluated in aqueous solutions by UV/H2O2 process...
  56. Qureshi A, Mueller S, Snyder A, Mukherjee P, Berman J, Roberts T, et al. Opposing brain differences in 16p11.2 deletion and duplication carriers. J Neurosci. 2014;34:11199-211 pubmed publisher
    Deletions and duplications of the recurrent ~600 kb chromosomal BP4-BP5 region of 16p11.2 are associated with a broad variety of neurodevelopmental outcomes including autism spectrum disorder...
  57. Assent D, Bourgot I, Hennuy B, Geurts P, Noël A, Foidart J, et al. A membrane-type-1 matrix metalloproteinase (MT1-MMP)-discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cells. PLoS ONE. 2015;10:e0116006 pubmed publisher
    ..in many aggressive tumours, promotes tumour progression by circumventing the collagen-induced up-regulation of BIK, a pro-apoptotic tumour suppressor, and hence apoptosis...
  58. Busacca S, Law E, Powley I, Proia D, Sequeira M, Le Quesne J, et al. Resistance to HSP90 inhibition involving loss of MCL1 addiction. Oncogene. 2016;35:1483-92 pubmed publisher
    ..first time that, to induce apoptosis, HSP90 inhibition requires the cooperation of multi BH3-only proteins (BID, BIK, PUMA) and the reciprocal suppression of the pro-survival BCL-2 family member MCL1, which occurs via inhibition of ..
  59. Prall W, Czibere A, Jager M, Spentzos D, Libermann T, Gattermann N, et al. Age-related transcription levels of KU70, MGST1 and BIK in CD34+ hematopoietic stem and progenitor cells. Mech Ageing Dev. 2007;128:503-10 pubmed
    ..genes encoding KU-antigen 70 kD (KU70), microsomal glutathione S-transferase 1 (MGST1) and BCL2-interacting killer (BIK) to possess age-related mRNA expression levels...
  60. van Keimpema M, Grüneberg L, Mokry M, van Boxtel R, Koster J, Coffer P, et al. FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells. Blood. 2014;124:3431-40 pubmed publisher
    ..Low expression of these genes, encoding the BH3-only proteins BIK and Harakiri, the p53-regulatory proteins TP63, RASSF6, and TP53INP1, and AIM2 and EAF2, is associated with poor ..
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    ..The combination augmented expression of Bik, Puma, and Bax, and attenuated Bcl-xL expression and the phosphorylation of Bad...
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    ..chlorine/chloramine and 2-hydroxyl-4-methoxyl benzophenone (BP3)/2-hydroxyl-4-methoxyl benzophenone-sulfonic acid (BP4), which were the most common reactions in benzophenone-type UV filters during drinking water treatment processes...
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    ..proteins Bcl-2 and Bcl-xL expression, whereas it up-regulated the pro-apoptotic proteins Bax, Bak, Bad, Bik and Puma expression...
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    BH3-only proteins are required for execution of apoptotic cell death. We have found that one of these proteins, Bik, is strongly induced in cancer cells treated with chemotherapeutic agents...
  66. Koppens M, Bounova G, Cornelissen Steijger P, de Vries N, Sansom O, Wessels L, et al. Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition. Oncotarget. 2016;7:69816-69828 pubmed publisher
    ..Response associated with the mutation status of ATRX and PAX2, and correlated with BIK expression...
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    Deletion of the recurrent ~600 kb BP4-BP5 chromosomal region 16p11.2 has been associated with a wide range of neurodevelopmental outcomes. To clarify the phenotype of 16p11...
  68. Oral A, Cevatemre B, Sarimahmut M, Icsel C, Yilmaz V, Ulukaya E. Anti-growth effect of a novel trans-dichloridobis[2-(2-hydroxyethyl)pyridine]platinum (II) complex via induction of apoptosis on breast cancer cell lines. Bioorg Med Chem. 2015;23:4303-10 pubmed publisher
    ..live, early/late apoptotic, dead cells and caspase 3/7 activity) and the RT-PCR (the genes analyzed were BCL-2L10, BIK, BAX, BCL-2, FASLG, HRK, TNFRSF10B, and TNFRSF10A)...
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    ..Laboratory analysis revealed high levels for both PBs and BP4, with maximum concentrations of 5700ngL(-1) and 1806ngL(-1), respectively, in influent samples, and 137ngL(-1) and ..
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    ..2HB), 2-Hydroxy-4-methoxybenzophenone (BP3), and 2-Hydroxy-4-methoxybenzophenone-5-sulfonicacid (BP4) in water were assayed in vitro using Vibrio fischeri, SOS/umu assay, and yeast estrogen screen (YES) assay, as ..
  72. Ruiz Esparza Garrido R, Torres Márquez M, Viedma Rodríguez R, Velázquez Wong A, Salamanca Gómez F, Rosas Vargas H, et al. Breast cancer cell line MDA-MB-231 miRNA profile expression after BIK interference: BIK involvement in autophagy. Tumour Biol. 2016;37:6749-59 pubmed publisher
    B-cell lymphoma 2 (BCL2)-interacting killer (apoptosis inducing) (BIK) has been proposed as a tumor suppressor in diverse types of cancers...
  73. Hippolyte L, Maillard A, Rodríguez Herreros B, Pain A, Martin Brevet S, Ferrari C, et al. The Number of Genomic Copies at the 16p11.2 Locus Modulates Language, Verbal Memory, and Inhibition. Biol Psychiatry. 2016;80:129-139 pubmed publisher
    Deletions and duplications of the 16p11.2 BP4-BP5 locus are prevalent copy number variations (CNVs), highly associated with autism spectrum disorder and schizophrenia...
  74. Berman J, Chudnovskaya D, Blaskey L, Kuschner E, Mukherjee P, Buckner R, et al. Relationship between M100 Auditory Evoked Response and Auditory Radiation Microstructure in 16p11.2 Deletion and Duplication Carriers. AJNR Am J Neuroradiol. 2016;37:1178-84 pubmed publisher
    Deletion and duplication of chromosome 16p11.2 (BP4-BP5) have been associated with developmental disorders such as autism spectrum disorders, and deletion subjects exhibit a large (20-ms) delay of the auditory evoked cortical response as ..
  75. Tomita T. Apoptosis in pancreatic ?-islet cells in Type 2 diabetes. Bosn J Basic Med Sci. 2016;16:162-79 pubmed publisher
    ..cell apoptosis has been extensively studied on the balance of pro-apoptotic Bcl-2 proteins (Bad, Bid, Bik, and Bax) and anti-apoptotic Bcl family (Bcl-2 and Bcl-xL) toward apoptosis in vitro isolated islets and insulinoma ..
  76. Demopoulos C, Kothare H, Mizuiri D, Henderson Sabes J, Fregeau B, Tjernagel J, et al. Abnormal Speech Motor Control in Individuals with 16p11.2 Deletions. Sci Rep. 2018;8:1274 pubmed publisher
    Speech and motor deficits are highly prevalent (>70%) in individuals with the 600 kb BP4-BP5 16p11...
  77. Ma Z, Leng Y, Chen G, Zhou P, Ye D, Chen L. The THERMOSENSITIVE MALE STERILE 1 Interacts with the BiPs via DnaJ Domain and Stimulates Their ATPase Enzyme Activities in Arabidopsis. PLoS ONE. 2015;10:e0132500 pubmed publisher
    ..GST pull-down and ATPase enzyme activity assays demonstrated that the DnaJ domain of TMS1 could interact with BiP1 and BiP3, and could stimulate their ATPase enzyme activities...
  78. Maruyama D, Endo T, Nishikawa S. BiP3 supports the early stages of female gametogenesis in the absence of BiP1 and BiP2 in Arabidopsis thaliana. Plant Signal Behav. 2015;10:e1035853 pubmed publisher
    ..Arabidopsis thaliana harbors ubiquitously expressed genes BIP1 and BIP2, as well as BIP3, which is induced only by ER stress...
  79. Hopkins T, Mura M, Al Ashtal H, Lahr R, Abd Latip N, Sweeney K, et al. The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer. Nucleic Acids Res. 2016;44:1227-46 pubmed publisher
    ..analysis following LARP1 knockdown, cross-referenced against the LARP1 interactome, we identify BCL2 and BIK as LARP1 mRNA targets...
  80. Wang Y, Liu Y, Hu C, Ni X, Huang X. Tumor necrosis factor ?-induced protein 8-like 1 promotes apoptosis by regulating B-cell leukemia/lymphoma-2 family proteins in RAW264.7 cells. Oncol Lett. 2016;12:3506-3512 pubmed
    ..upregulate the expression of B-cell leukemia/lymphoma (Bcl)-2 associated X protein (Bax), Bcl-2 interacting killer (Bik) and p53 upregulated modulator of apoptosis (Puma), and activate the mitogen activated protein kinases (MAPKs) ..
  81. Yu C, Gong Y, Zhou H, Wang M, Kong L, Liu J, et al. Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model. Cell Death Dis. 2017;8:e2582 pubmed publisher
    ..Moreover, by regulating the expression of BIK (BCL2-interacting killer), Star-PAP induced apoptosis of breast cancer cells through the mitochondrial pathway...
  82. Palmiotto M, Castiglioni S, Zuccato E, Manenti A, Riva F, Davoli E. Personal care products in surface, ground and wastewater of a complex aquifer system, a potential planning tool for contemporary urban settings. J Environ Manage. 2018;214:76-85 pubmed publisher
    ..We investigated four UV filters: phenylbenzimidazole sulfonic acid (PBSA), benzophenone-3 (BP3), benzophenone-4 (BP4) and 4 methyl-benzilidine-camphor (4-MBC), and two antibacterial agents: triclosan (TCS) and triclocarban (TCC)...
  83. Huynh M, Lambert A, Tosca L, Petit F, Philippe C, Parisot F, et al. 15q24.1 BP4-BP1 microdeletion unmasking paternally inherited functional polymorphisms combined with distal 15q24.2q24.3 duplication in a patient with epilepsy, psychomotor delay, overweight, ventricular arrhythmia. Eur J Med Genet. 2018;61:459-464 pubmed publisher
    ..180K array-CGH analysis identified a 1.38 Mb heterozygous interstitial 15q24.1 BP4-BP1 microdeletion including HCN4 combined with a concomitant 2.6 Mb heterozygous distal 15q24.2q24...
  84. Hur J, Chesnes J, Coser K, Lee R, Geck P, Isselbacher K, et al. The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis. Proc Natl Acad Sci U S A. 2004;101:2351-6 pubmed
    ..changes in the gene expression profile of MCF-7/BUS human breast cancer cells and revealed a strong induction of Bik, a member of the BH3-only proapoptotic proteins...
  85. Huang J, Wang L, Jiang M, Chen Q, Zhang X, Wang Y, et al. Low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384. Immunol Res. 2016;64:461-9 pubmed publisher
    Eighteen different Pearson mutual-positive-correlation BIK-activatory molecular feedback upstream and downstream networks were constructed from 79 overlapping of 376 GRNInfer and 98 Pearson under BIK CC ≥ 0...
  86. Ma B, Lu G, Liu F, Nie Y, Zhang Z, Li Y. Organic UV Filters in the Surface Water of Nanjing, China: Occurrence, Distribution and Ecological Risk Assessment. Bull Environ Contam Toxicol. 2016;96:530-5 pubmed publisher
    ..The results indicated butyl-methoxydibenzoylmethane, octyl-dimethyl-PABA and benzophenone-types (BP3, BP4 and BP1) were the most frequently detected compounds at concentrations of 3.63-104 ng/L...
  87. Pandya V, Glubrecht D, Vos L, Hanson J, Damaraju S, Mackey J, et al. The pro-apoptotic paradox: the BH3-only protein Bcl-2 interacting killer (Bik) is prognostic for unfavorable outcomes in breast cancer. Oncotarget. 2016;7:33272-85 pubmed publisher
    ..Using gene and tissue microarray analyses, we identified an association of Bcl-2 interacting killer (Bik) with poor breast cancer prognosis...
  88. Dalal S, Zha Q, Singh M, Singh K. Osteopontin-stimulated apoptosis in cardiac myocytes involves oxidative stress and mitochondrial death pathway: role of a pro-apoptotic protein BIK. Mol Cell Biochem. 2016;418:1-11 pubmed publisher
    ..OPN increased expression of BIK, a pro-apoptotic protein involved in reorganization of mitochondrial cristae...
  89. Chand H, Harris J, Tesfaigzi Y. IL-13 in LPS-Induced Inflammation Causes Bcl-2 Expression to Sustain Hyperplastic Mucous cells. Sci Rep. 2018;8:436 pubmed publisher
    ..were reduced due to increased apoptosis that disrupted the interaction of Bcl-2 with the pro-apoptotic protein, Bik. Furthermore, intranasal instillation of ABT-263 reduced the LPS-induced MCH in bik +/+ but not bik ..
  90. Federici M, Hribal M, Perego L, Ranalli M, Caradonna Z, Perego C, et al. High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program. Diabetes. 2001;50:1290-301 pubmed
    ..On the other hand, proapoptotic genes Bad, Bid, and Bik were overexpressed in the islets maintained in HG5...
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    ..The phylogenetic relationship between rhomboids and the ERAD factor derlin suggests that substrates for intramembrane proteolysis and protein dislocation are recruited by a shared mechanism. ..
  92. Rautureau G, Yabal M, Yang H, Huang D, Kvansakul M, Hinds M. The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist. Cell Death Dis. 2012;3:e443 pubmed publisher
    ..Bcl-B has high-affinity interactions with Bim and Bik only...