biglycan

Summary

Gene Symbol: biglycan
Description: biglycan
Alias: DSPG1, MRLS, PG-S1, PGI, SEMDX, SLRR1A, biglycan, bone/cartilage proteoglycan-I, dermatan sulphate proteoglycan I, small leucine-rich protein 1A
Species: human
Products:     biglycan

Top Publications

  1. Fleischmajer R, Fisher L, MacDonald E, Jacobs L, Perlish J, Termine J. Decorin interacts with fibrillar collagen of embryonic and adult human skin. J Struct Biol. 1991;106:82-90 pubmed
    b>Biglycan (PG-I, BGN) and decorin (PG-II, DCN) are small proteoglycans that have been isolated in cartilage, skin, and bone...
  2. Hildebrand A, Romaris M, Rasmussen L, Heinegard D, Twardzik D, Border W, et al. Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta. Biochem J. 1994;302 ( Pt 2):527-34 pubmed
    We have analysed the interactions of three proteoglycans of the decorin family, decorin, biglycan and fibromodulin, with transforming growth factor beta (TGF-beta)...
  3. Iozzo R. The biology of the small leucine-rich proteoglycans. Functional network of interactive proteins. J Biol Chem. 1999;274:18843-6 pubmed
  4. Bianco P, Fisher L, Young M, Termine J, Robey P. Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues. J Histochem Cytochem. 1990;38:1549-63 pubmed
    The messenger RNAs and core proteins of the two small chondroitin/dermatan sulfate proteoglycans, biglycan and decorin, were localized in developing human bone and other tissues by both 35S-labeled RNA probes and antibodies directed ..
  5. Fisher L, Termine J, Young M. Deduced protein sequence of bone small proteoglycan I (biglycan) shows homology with proteoglycan II (decorin) and several nonconnective tissue proteins in a variety of species. J Biol Chem. 1989;264:4571-6 pubmed
    ..For this reason, we suggest that PG I be called biglycan. The biglycan protein sequence contains 368 residues (Mr = 42,510 for the complete sequence and Mr = 37,983 for ..
  6. Schonherr E, Witsch Prehm P, Harrach B, Robenek H, Rauterberg J, Kresse H. Interaction of biglycan with type I collagen. J Biol Chem. 1995;270:2776-83 pubmed
    ..The structurally related proteoglycan biglycan has been proposed not to bind to fibrillar collagens...
  7. Xu T, Bianco P, Fisher L, Longenecker G, Smith E, Goldstein S, et al. Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice. Nat Genet. 1998;20:78-82 pubmed
    ..b>Biglycan (encoded by the gene Bgn) is an ECM proteoglycan that is enriched in bone and other non-skeletal connective ..
  8. Ito M, Ohno K. Protein-anchoring therapy to target extracellular matrix proteins to their physiological destinations. Matrix Biol. 2018;68-69:628-636 pubmed publisher
    ..ColQ is an extracellular matrix (ECM) protein that anchors AChE to the synaptic basal lamina. Biglycan, encoded by BGN, is another ECM protein that binds to the dystrophin-associated protein complex (DAPC) on ..
  9. Gryglewski R, Mackiewicz Z. Vane's blood-bathed organ technique adapted to examine the endothelial effects of cardiovascular drugs in vivo. Pharmacol Rep. 2010;62:462-7 pubmed
    ..Other PGI(2)-releasers included statins (e.g., atorvastatin and simvastatin), thienopyridines (e.g...

More Information

Publications136 found, 100 shown here

  1. Fan H, Li M, Yu L, Jin W, Yang J, Zhang Y, et al. Effects of Danhong Injection on platelet aggregation in hyperlipidemia rats. J Ethnopharmacol. 2018;212:67-73 pubmed publisher
    ..Moreover, the expression of prostaglandin I-2 (PGI2), prostaglandin E-2 (PGE2) and thromboxane A2 (TXA2) in liver was determined by ..
  2. Cheng Z, Shen X, Jiang X, Shan H, CIMINI M, Fang P, et al. Hyperhomocysteinemia potentiates diabetes-impaired EDHF-induced vascular relaxation: Role of insufficient hydrogen sulfide. Redox Biol. 2018;16:215-225 pubmed publisher
    ..ACh), determined by the presence of eNOS inhibitor N(ω)-nitro-L-arginine methyl ester (L-NAME) and prostacyclin (PGI2) inhibitor indomethacin (INDO), in SMA from db/db mice but not that from db/+ mice...
  3. Ho H, Hsu S, Lee F, Huang H, Hsin I, Hou M, et al. Role of cyclooxygenase isoforms in encephalopathy of cirrhotic rats. J Chin Med Assoc. 2016;79:583-588 pubmed publisher
    ..6-keto-prostaglandin-F [6-keto-PGF; a relatively stable metabolite of prostacyclin (PGI2)], alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALK-P), and total ..
  4. Jiang C, Fang Z, Zhou D, Pan S, Ye X. Changes in secondary metabolites, organic acids and soluble sugars during the development of plum fruit cv. 'Furongli' (Prunus salicina Lindl). J Sci Food Agric. 2019;99:1010-1019 pubmed publisher
    ..Fructose content decreased with increasing phosphoglucoisomerase (PGI) activity, whereas glucose content increased with decreasing hexokinase (HK) activity...
  5. Cook M, Dawsey S, Diaw L, Blaser M, Perez Perez G, Abnet C, et al. Serum pepsinogens and Helicobacter pylori in relation to the risk of esophageal squamous cell carcinoma in the alpha-tocopherol, beta-carotene cancer prevention study. Cancer Epidemiol Biomarkers Prev. 2010;19:1966-75 pubmed publisher
    ..G antibodies against whole-cell and CagA antigens) and gastric atrophy status [via the biomarkers pepsinogen I (PGI) and pepsinogen II (PGII)] in 79 ESCC cases and 94 controls...
  6. Xiong Y, Yao H, Cheng Y, Gong D, Liao X, Wang R. Effects of monoacylglycerol lipase inhibitor URB602 on lung ischemia-reperfusion injury in mice. Biochem Biophys Res Commun. 2018;506:578-584 pubmed publisher
    ..including 2-AG, anandamide (AEA) and arachidonic acid (AA) levels, metabolites such as Prostaglandin I2 (PGI2), Thromboxane B2 (TXB2) and Leukotrienes B4 (LTB4) and ..
  7. Nilius B, Droogmans G. Ion channels and their functional role in vascular endothelium. Physiol Rev. 2001;81:1415-59 pubmed
    ..g., nitric oxide and PGI(2)...
  8. Grandoch M, Kohlmorgen C, Melchior Becker A, Feldmann K, Homann S, Muller J, et al. Loss of Biglycan Enhances Thrombin Generation in Apolipoprotein E-Deficient Mice: Implications for Inflammation and Atherosclerosis. Arterioscler Thromb Vasc Biol. 2016;36:e41-50 pubmed publisher
    ..Here, the question was addressed whether the small leucine-rich proteoglycan biglycan acts as an endogenous thrombin inhibitor in atherosclerosis through activation of heparin cofactor II...
  9. Fallon J, McNally E. Non-Glycanated Biglycan and LTBP4: Leveraging the extracellular matrix for Duchenne Muscular Dystrophy therapeutics. Matrix Biol. 2018;68-69:616-627 pubmed publisher
    ..b>Biglycan is a small leucine rich repeat ECM protein present as two glycoforms in muscle that have dramatically different ..
  10. Jayaram S, Kapoor S, Dharmesh S. Pectic polysaccharide from corn (Zea mays L.) effectively inhibited multi-step mediated cancer cell growth and metastasis. Chem Biol Interact. 2015;235:63-75 pubmed publisher
    ..invasion, NF-κB, a transcription factor for proliferative potency of tumor cells and a phosphoglucoisomerase (PGI), the activity of which favors cancer cell growth...
  11. Tanaka H, Ohtsu A, Shiratsuki S, Kawahara Miki R, Iwata H, Kuwayama T, et al. Age-dependent changes in inflammation and extracellular matrix in bovine oviduct epithelial cells during the post-ovulatory phase. Mol Reprod Dev. 2016;83:815-826 pubmed publisher
    ..Mol. Reprod. Dev. 83: 815-826, 2016 © 2016 Wiley Periodicals, Inc. ..
  12. Rana S, Morya R, Malik A, Bhadada S, Sachdeva N, Sharma G. A relationship between vitamin D, parathyroid hormone, calcium levels and lactose intolerance in type 2 diabetic patients and healthy subjects. Clin Chim Acta. 2016;462:174-177 pubmed publisher
    ..150 type 2 diabetic patients attending Endocrinology Clinic in PGI, Chandigarh and 150 age and sex matched healthy controls were enrolled...
  13. Rieg A, Suleiman S, Anker C, Verjans E, Rossaint R, Uhlig S, et al. PDGF-BB regulates the pulmonary vascular tone: impact of prostaglandins, calcium, MAPK- and PI3K/AKT/mTOR signalling and actin polymerisation in pulmonary veins of guinea pigs. Respir Res. 2018;19:120 pubmed publisher
    ..samples were analysed (ELISA) to detect the PDGF-BB-induced release of prostaglandin metabolites (TXA2/PGI2). In PCLS, the contractile effect of PDGF-BB was evaluated in pulmonary arteries (PAs) and PVs...
  14. Yan Y, Ao L, Zhou L, Li C, Fang W, Shen W, et al. Therapeutic effects of JLX001 on cerebral ischemia through inhibiting platelet activation and thrombus formation in rats. Biomed Pharmacother. 2018;106:805-812 pubmed publisher
    ..Brain TXA2 and prostacyclin (PGI2) were measured by enzyme-linked immunosorbentassay (ELISA)...
  15. Abdulmajeed N, Alnahdi H, Ayas N, Mohamed A. Amelioration of cardiotoxic impacts of diclofenac sodium by vitamin B complex. Eur Rev Med Pharmacol Sci. 2015;19:671-81 pubmed
    ..of cardiac damage, including, (AST), creatine kinase-MB (CK-MB) as well as decreases in phosphoglucoisomerase (PGI) and lactate dehydrogenase (LDH) activities in cardiac tissue compared with intoxicated rats...
  16. Palumbo S, Toscano C, Parente L, Weigert R, Bosetti F. Time-dependent changes in the brain arachidonic acid cascade during cuprizone-induced demyelination and remyelination. Prostaglandins Leukot Essent Fatty Acids. 2011;85:29-35 pubmed publisher
    ..Levels of PGE(2), PGD(2), PGI(2) and TXB(2) were also increased during demyelination...
  17. Ryan A, Baker A, Dark F, Foley S, Gordon A, Hatherill S, et al. The efficacy of sodium benzoate as an adjunctive treatment in early psychosis - CADENCE-BZ: study protocol for a randomized controlled trial. Trials. 2017;18:165 pubmed publisher
    ..rating Scale-17 items (HDRS), Opiate Treatment Index (OTI) and the Patients' Global Impression of Improvement (PGI-I)...
  18. Yoshida E, Kurita M, Eto K, Kumagai Y, Kaji T. Methylmercury promotes prostacyclin release from cultured human brain microvascular endothelial cells via induction of cyclooxygenase-2 through activation of the EGFR-p38 MAPK pathway by inhibiting protein tyrosine phosphatase 1B activity. Toxicology. 2017;392:40-46 pubmed publisher
    ..Since prostaglandins I2 and E2 (PGI2 and PGE2) increase vascular permeability and contribute to the progression of inflammatory ..
  19. Qiu J, Lingna W, Jinghong H, Yongqing Z. Oral administration of leeches (Shuizhi): A review of the mechanisms of action on antiplatelet aggregation. J Ethnopharmacol. 2019;232:103-109 pubmed publisher
    ..animal medicine, they can prevent platelet aggregation by inhibiting ADP-induced platelet aggregation, increasing PGI2, decreasing TXA2 and Ca2+, and possibly recovering endothelial cell dysfunction...
  20. Frisbee J. Impaired dilation of skeletal muscle microvessels to reduced oxygen tension in diabetic obese Zucker rats. Am J Physiol Heart Circ Physiol. 2001;281:H1568-74 pubmed
    ..that hypoxic dilation of skeletal muscle microvessels from LZR represents the summated effects of prostanoid and nitric oxide release, whereas the impaired response of vessels in OZR may reflect scavenging of PGI(2) by superoxide anion.
  21. Avendaño M, Garcia Redondo A, Zalba G, González Amor M, Aguado A, Martinez Revelles S, et al. mPGES-1 (Microsomal Prostaglandin E Synthase-1) Mediates Vascular Dysfunction in Hypertension Through Oxidative Stress. Hypertension. 2018;72:492-502 pubmed publisher
    ..Deletion of mPGES-1 augmented vascular production of PGI2 suggesting rediversion of the accumulated PGH2 substrate...
  22. Haidar B, Ferdous M, Fatema B, Ferdous A, Islam M, Khan H. Population diversity of bacterial endophytes from jute (Corchorus olitorius) and evaluation of their potential role as bioinoculants. Microbiol Res. 2018;208:43-53 pubmed publisher
    ..to be the most effective, having 82% and 53% of relative inhibition ratio (RIR) and percent growth inhibition (PGI) values respectively...
  23. Wang W, Liu M, You C, Li Z, Zhang Y. ATP-free biosynthesis of a high-energy phosphate metabolite fructose 1,6-diphosphate by in vitro metabolic engineering. Metab Eng. 2017;42:168-174 pubmed publisher
    ..2 and 70°C, respectively. The optimal enzyme ratios of ?GP, PGM, PGI and PFK were 2:2:1:2 in terms of units. Via step-wise addition of new substrates, up to 125 ± 4...
  24. Santiago E, Martínez M, Climent B, MUNOZ M, Bríones A, Salaices M, et al. Augmented oxidative stress and preserved vasoconstriction induced by hydrogen peroxide in coronary arteries in obesity: role of COX-2. Br J Pharmacol. 2016;173:3176-3195 pubmed publisher
    ..b>PGI2 (IP) receptor antagonism modestly reduced the vasoconstrictor action of H2 O2 ..
  25. Salmon C, Giorgetti A, Paes Leme A, Domingues R, Kolli T, Foster B, et al. Microproteome of dentoalveolar tissues. Bone. 2017;101:219-229 pubmed publisher
    ..of expected ECM proteins including collagen alpha-1(I) chain (COL1A1), collagen alpha-1(XII) chain (COL12A1), biglycan (BGN), asporin (ASPN), lumican (LUM), and fibromodulin (FMOD), served to validate the approach...
  26. Roman L, Lukyanchuk R, Sablin O, Araslanova E, Eklund C, Hendolin P, et al. Prevalence of H. pylori Infection and Atrophic Gastritis in a Population-based Screening with Serum Biomarker Panel (GastroPanel®) in St. Petersburg. Anticancer Res. 2016;36:4129-38 pubmed
    ..895 (95%CI=0.837-0.953). Using the AGC2+ end-point, verification bias-corrected specificity of PGI reached 96.4% (95%CI=94.7-97.9) and that of PGI/PGII ratio 94.6% (95%CI=92.6-96...
  27. Palla M, Cristani C, Giovannetti M, Agnolucci M. Identification and characterization of lactic acid bacteria and yeasts of PDO Tuscan bread sourdough by culture dependent and independent methods. Int J Food Microbiol. 2017;250:19-26 pubmed publisher
    ..has been recorded in Italy, including special types selected as worthy of either Protected Geographical Indication (PGI) or Protected Designation of Origin (PDO), whose sourdough microbiota has been functionally and molecularly ..
  28. McBride O, Fisher L, Young M. Localization of PGI (biglycan, BGN) and PGII (decorin, DCN, PG-40) genes on human chromosomes Xq13-qter and 12q, respectively. Genomics. 1990;6:219-25 pubmed
    The genes for PGI (biglycan, BGN) and PGII (decorin, DCN) have been assigned to human chromosomes X and 12 by Southern analysis of a panel of human-rodent somatic cell hybrid DNAs with cDNA probes for these related small proteoglycans...
  29. Murthi P, Faisal F, Rajaraman G, Stevenson J, Ignjatovic V, Monagle P, et al. Placental biglycan expression is decreased in human idiopathic fetal growth restriction. Placenta. 2010;31:712-7 pubmed publisher
    ..This study hypothesised that the expression of biglycan proteoglycan, a source of DS, is decreased in idiopathic FGR placentae compared with placentae from uncomplicated ..
  30. Foudi N, Ozen G, Amgoud Y, Louedec L, Choqueux C, Badi A, et al. Decreased vasorelaxation induced by iloprost during acute inflammation in human internal mammary artery. Eur J Pharmacol. 2017;804:31-37 pubmed publisher
    ..This effect was associated with increased prostaglandin (PG) E2 and prostacyclin (PGI2) releases...
  31. Beharry K, Cai C, Soontarapornchai K, Ahmad T, Valencia G, Aranda J. Intermittent hypoxia alters dose dependent caffeine effects on renal prostanoids and receptors in neonatal rats. Prostaglandins Other Lipid Mediat. 2018;134:57-65 pubmed publisher
    ..This was associated with reductions in anthropometric growth, PGI2, and IP, DP, and AQP-4 immunoreactivity, well as a robust increase in COX-2, suggesting that the use of ..
  32. Loong T, Soon N, Nik Mahmud N, Naidu J, Rani R, Abdul Hamid N, et al. Serum pepsinogen and gastrin-17 as potential biomarkers for pre-malignant lesions in the gastric corpus. Biomed Rep. 2017;7:460-468 pubmed publisher
    ..Thus, the aim of the present study was to determine the sensitivity and specificity of serum pepsinogen I (PGI), PGI:II, the PGI:II ratio and gastrin-17 (G-17) in diagnosing CAG and IM, and the correlations between these serum ..
  33. Totoson P, Pedard M, Marie C, Demougeot C. Activation of endothelial TrkB receptors induces relaxation of resistance arteries. Vascul Pharmacol. 2018;106:46-53 pubmed publisher
    ..in the relaxation of resistance vessels via PI3K/Akt-induced eNOS phosphorylation and production of EDHF and PGI2...
  34. Shimizu Hirota R, Sasamura H, Kuroda M, Kobayashi E, Hayashi M, Saruta T. Extracellular matrix glycoprotein biglycan enhances vascular smooth muscle cell proliferation and migration. Circ Res. 2004;94:1067-74 pubmed
    ..Because the small leucine-rich proteoglycan (SLRP) biglycan is overexpressed in arteriosclerotic lesions, we produced mice constitutively overexpressing biglycan in the ..
  35. Stephens E, Saltarrelli J, Baggett L, Nandi I, Kuo J, Davis A, et al. Differential proteoglycan and hyaluronan distribution in calcified aortic valves. Cardiovasc Pathol. 2011;20:334-42 pubmed publisher
    ..valves removed during valve replacement surgery were immunohistochemically stained for the proteoglycans decorin, biglycan, and versican, as well as the glycosaminoglycan hyaluronan...
  36. Rajendran G, Krishnakumar P, Feroze M, Gireeshan V. Cognitive Functions and Psychological Problems in Children with Sickle Cell Anemia. Indian Pediatr. 2016;53:485-8 pubmed
    ..Malins Intelligence Scale for Indian children, modified PGI memory scale, and Childhood Psychopathology Measurement Schedule were used to assess cognitive functions and ..
  37. Li N, Yin J, Cai W, Liu J, Zhang N, Yan S, et al. Coupling Factor 6 Is Upregulated in Monocrotaline-induced Pulmonary Arterial Hypertension in Rats. Am J Med Sci. 2016;352:631-636 pubmed publisher
    Pulmonary arterial hypertension (PAH) is a rare and fatal disease. The prostacyclin (PGI2) pathway is a well-known therapeutic target for PAH...
  38. Gatfield J, Menyhart K, Wanner D, Gnerre C, Monnier L, Morrison K, et al. Selexipag Active Metabolite ACT-333679 Displays Strong Anticontractile and Antiremodeling Effects but Low β-Arrestin Recruitment and Desensitization Potential. J Pharmacol Exp Ther. 2017;362:186-199 pubmed publisher
    Prostacyclin (PGI2) receptor (IP receptor) agonists, which are indicated for the treatment of pulmonary arterial hypertension (PAH), increase cytosolic cAMP levels and thereby inhibit pulmonary vasoconstriction, pulmonary ..
  39. Das S, Metzenberg A, Pai G, Gitschier J. Mutational analysis of the biglycan gene excludes it as a candidate for X-linked dominant chondrodysplasia punctata, dyskeratosis congenita, and incontinentia pigmenti. Am J Hum Genet. 1994;54:922-5 pubmed
  40. Szymanska M, Blitek A. Endometrial and conceptus response to exogenous progesterone treatment in early pregnant gilts following hormonally-induced estrus. Anim Reprod Sci. 2016;174:56-64 pubmed publisher
    ..gilts with P4 increased uterine weight and enhanced total protein content and 6-keto PGF1? (a PGI2 metabolite) content in the uterine lumen...
  41. Abdel Fattah M, Cao G, Mostafa A. Long-term outcomes of transobturator tension-free vaginal tapes as secondary continence procedures. World J Urol. 2017;35:1141-1148 pubmed publisher
    ..was the patient-reported success rate defined as very/much improved on Patient's Global Impression of Improvement (PGI-I). Secondary outcomes included late adverse events and impact on women's quality of life and sexual function...
  42. Antosik Wójcińska A, Swiecicki Ł, Dominiak M, Sołtan E, Bienkowski P, Mandat T. Impact of STN-DBS on mood, drive, anhedonia and risk of psychiatric side-effects in the population of PD patients. J Neurol Sci. 2017;375:342-347 pubmed publisher
    ..state and psychiatric side effects were assessed with the use of MADRS, HADRS, BDI, BPRS, YMS, SHAPS, CGI and PGI rating scales...
  43. Sun C, Yuan Q, Wu D, Meng X, Wang B. Identification of core genes and outcome in gastric cancer using bioinformatics analysis. Oncotarget. 2017;8:70271-70280 pubmed publisher
    ..In addition, it could be used as a new biomarker for diagnosis and to guide the combination medicine of gastric cancer...
  44. Yoshio K, Mitsuhashi T, Wakita A, Kitayama T, Hisazumi K, Inoue D, et al. Plan quality comparison between 4-arc and 6-arc noncoplanar volumetric modulated arc stereotactic radiotherapy for the treatment of multiple brain metastases. Med Dosim. 2018;43:358-362 pubmed publisher
    ..Radiation Therapy Oncology Group and Paddick conformity indices (RCI and PCI), fall-off (Paddick gradient index [PGI]), and the normal brain dose. The median (range) RCI, PCI, and PGI was 0.94 (0.92 to 0.99), 0.89 (0.77 to 0...
  45. Trochez R, Lane S, Duckett J. The use of synthetic mesh for vaginal prolapse in the UK: a review of cases submitted to the British Society of Urogynaecology database. Int Urogynecol J. 2018;29:899-904 pubmed publisher
    ..The primary outcome was based on the reported patient global impression of improvement (PGI-I). A total of 6,709 cases of mesh prolapse repair were entered during the study period...
  46. Matuszewski P, Chen Y, Szczesny S, Lake S, Elliott D, Soslowsky L, et al. Regional variation in human supraspinatus tendon proteoglycans: decorin, biglycan, and aggrecan. Connect Tissue Res. 2012;53:343-8 pubmed publisher
    ..The concentration of aggrecan, biglycan, and decorin was determined in six regions of the human SST using immunochemical techniques...
  47. Zou W, Al Rubeai M. Understanding central carbon metabolism of rapidly proliferating mammalian cells based on analysis of key enzymatic activities in GS-CHO cell lines. Biotechnol Appl Biochem. 2016;63:642-651 pubmed publisher
    ..In addition, the multifaceted role of glucose-6-phosphate isomerase (PGI) was confirmed, based on a significant correlation between PGI activity and the percentage of G2/M-phase cells.
  48. Osmundsen B, Gregory W, Denman M, Adams K, Edwards R, Clark A. Tension-Free Vaginal Tape Failure After Robotic Sacrocolpopexy and Tension-Free Vaginal Tape for Concomitant Prolapse and Stress Incontinence. Female Pelvic Med Reconstr Surg. 2015;21:244-8 pubmed publisher
    ..Outcomes assessed at 12 months: CST (primary aim), Patient Global Impression of Improvement (PGI-I), Pelvic Floor Distress Inventory, and the Sandvik questionnaire...
  49. Koskenpato K, Ainola M, Przybyla B, Kouri V, Virkki L, Koskenpato J, et al. Diminished salivary epidermal growth factor secretion: a link between Sjögren's syndrome and autoimmune gastritis?. Scand J Rheumatol. 2016;45:118-21 pubmed publisher
    ..002). Proton-pump positive parietal cells were mostly EGFR immunoreactive whereas very few pepsinogen I (PGI)-positive cells were EGFR positive...
  50. Xu Y, Zhang Y, Xu C, Liu N. [Effect of Lymphocyte/Monocyte Ratio on Clinical Features and Prognosis of Patients with Primary Gastrointestinal Diffuse Large B Cell Lymphoma]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:1404-1409 pubmed publisher
    ..on clinical features and prognosis of patients with primary gastrointestinal diffuse large B cell lymphoma(PGI-DLBCL)...
  51. Hiukka A, Ståhlman M, Pettersson C, Levin M, Adiels M, Teneberg S, et al. ApoCIII-enriched LDL in type 2 diabetes displays altered lipid composition, increased susceptibility for sphingomyelinase, and increased binding to biglycan. Diabetes. 2009;58:2018-26 pubmed publisher
    ..LDL was isolated from control subjects, subjects with type 2 diabetes, and apoB transgenic mice. LDL-biglycan binding was analyzed with a solid-phase assay using immunoplates coated with biglycan...
  52. Aburub A, Gagnon B, Rodriguez A, Mayo N. Using a personalized measure (Patient Generated Index (PGI)) to identify what matters to people with cancer. Support Care Cancer. 2016;24:437-445 pubmed publisher
    Patient Generated Index (PGI) is designed to both ask and document quality of life (QOL) concerns. Its validity with respect to standard QOL measures has not been fully established for advanced cancer when QOL concerns predominate...
  53. Wang Z, Shi S, Li S, Chen F, Chen H, Lin H, et al. Efficacy and Safety of Duloxetine on Osteoarthritis Knee Pain: A Meta-Analysis of Randomized Controlled Trials. Pain Med. 2015;16:1373-85 pubmed publisher
    ..with specific data regarding to pain reductions and response rate, Patient Global Impression of Improvement (PGI-I), functional improvement, Western Ontario and McMaster Osteoarthritis Index (WOMAC), adverse events (AEs), ..
  54. Myren M, Kirby D, Noonan M, Maeda A, Owens R, Ricard Blum S, et al. Biglycan potentially regulates angiogenesis during fracture repair by altering expression and function of endostatin. Matrix Biol. 2016;52-54:141-150 pubmed publisher
    The small proteoglycan biglycan (Bgn) is highly expressed in the organic matrix of bone and plays a role in bone formation. Previous work implicated Bgn in vessel growth during bone healing [1]...
  55. Wrzyszcz A, Urbaniak J, Sapa A, Woźniak M. An efficient method for isolation of representative and contamination-free population of blood platelets for proteomic studies. Platelets. 2017;28:43-53 pubmed publisher
    ..we have developed a method which combines the continuous density gradient centrifugation with washing from PGI2-supplemented platelet-rich plasma (PRP)...
  56. Frigerio M, Regini C, Manodoro S, Spelzini F, Milani R. Mini-sling efficacy in obese versus non-obese patients for treatment of stress urinary incontinence. Minerva Ginecol. 2017;69:533-537 pubmed publisher
    ..Objective cure rate was assessed with stress test and subjective cure rate was determined by ICIQ-SF and PGI-I scores. Postoperative overactive bladder syndrome and voiding symptoms were recorded...
  57. Schwartz J, Musser B, Tanaka W, Taggart W, Mehta A, Gottesdiener K, et al. Inhibition of prostacyclin and thromboxane biosynthesis in healthy volunteers by single and multiple doses of acetaminophen and indomethacin. Clin Pharmacol Drug Dev. 2015;4:337-45 pubmed publisher
    ..Urinary excretion of 2,3-dinor-6-keto-PGF1?, (prostacyclin metabolite, PGI-M; COX-2 inhibition) and 11-dehydro thromboxane B2 (thromboxane metabolite, Tx-M; COX-1 inhibition) were measured ..
  58. Tuncer M, Tarhan F, Kafkaslı A, Demir K, Yucetas U, Faydaci G, et al. The effects of stress incontinence surgery on sexual function and life quality of women. Arch Ital Urol Androl. 2016;88:106-10 pubmed publisher
    ..Patient Global Impression of Improvement (PGI-I) questionnare was added postoperatively...
  59. Bach F, Toozs Hobson P. What can we learn from large data sets? An analysis of 19,000 retropubic tapes. Int Urogynecol J. 2017;28:629-636 pubmed publisher
    ..8 % of patients felt better on the Patient Global Impression of Improvement of Incontinence (PGI) scale. There was a significant difference (p?<?0...
  60. Dai Z, Li C, Wang X, Shu H, Zhang K, Dai C. A new laparoscopic technique of inguinal ligament suspension for vaginal vault prolapse. Int J Surg. 2017;43:131-136 pubmed publisher
    ..evaluated according to Pelvic organ prolapse questionnaire (POP-Q) and Patient Global Impression of Improvement (PGI-I) scale...
  61. Willard K, Mannion S, Saunders C, Collins M, September A. The interaction of polymorphisms in extracellular matrix genes and underlying miRNA motifs that modulate susceptibility to anterior cruciate ligament rupture. J Sci Med Sport. 2018;21:22-28 pubmed publisher
    ..The biological significance of these genomic signatures needs to be explored to understand their effect on the ligaments functional capacity. ..
  62. Balsamo R, Illiano E, Zucchi A, Natale F, Carbone A, Sio M, et al. Sacrocolpopexy with polyvinylidene fluoride mesh for pelvic organ prolapse: Mid term comparative outcomes with polypropylene mesh. Eur J Obstet Gynecol Reprod Biol. 2018;220:74-78 pubmed publisher
    ..Global patient perception of improvement (PGI-I questionnaire) and mesh erosion rates were also recorded...
  63. Albuquerque T, Oliveira M, Costa H. 25?years of EU quality schemes for agricultural products and foodstuffs across EU Member States. J Sci Food Agric. 2017;: pubmed publisher
    ..the last 25 years of EU quality schemes (Protected Designation of Origin (PDO), Protected Geographical Indication (PGI) and Traditional Speciality Guaranteed (TSG)) on agricultural products and foodstuffs across the 28 EU Member ..
  64. Heegaard A, Xie Z, Young M, Nielsen K. Transforming growth factor beta stimulation of biglycan gene expression is potentially mediated by sp1 binding factors. J Cell Biochem. 2004;93:463-75 pubmed
    b>Biglycan is a small leucine-rich proteoglycan which is localized in the extracellular matrix of bone and other specialized connective tissues...
  65. Schellart R, Oude Rengerink K, Van Der Aa F, Lucot J, Kimpe B, Dijkgraaf M, et al. A randomised comparison of single-incision versus traditional transobturator midurethral sling in women with stress urinary incontinence: results of a 24-month follow-up. Int Urogynecol J. 2016;27:871-7 pubmed publisher
    ..Primary outcome was subjective cure, defined as an improvement on the Patient Global Impression of Improvement (PGI-I), at 12, 24 and 36 months...
  66. Niedworok C, Panitz M, Szarvas T, Reis H, Reis A, Szendroi A, et al. Urachal Carcinoma of the Bladder: Impact of Clinical and Immunohistochemical Parameters on Prognosis. J Urol. 2016;195:1690-6 pubmed publisher
    ..Our results in a limited number of samples show that Ki67, p53, RHAMM and IMP3 expression is enhanced but has no prognostic significance in urachal carcinoma of the bladder. ..
  67. Hogewoning C, Elzevier H, Pelger R, Hogewoning C. Results of collagen sling placement following the partial removal of a synthetic midurethral sling. Int J Gynaecol Obstet. 2016;134:286-9 pubmed publisher
    ..subjective improvement or deterioration in symptoms was scored using the Patient Global Impression of Improvement (PGI-I). The questionnaire was completed and returned by 32 (84%) of 38 patients after a mean follow-up of 54.3 months...
  68. Zhuang H, Chen Z, Feng T, Yang Y, Zhang J, Liu G, et al. Characterization of Lentinus edodes ?-glucan influencing the in vitro starch digestibility of wheat starch gel. Food Chem. 2017;224:294-301 pubmed publisher
    ..Furthermore, LEBG can significantly inhibit starch hydrolysis. The predicted glycemic index (pGI) values were reduced when starch was replaced with LEBG at 20% (w/w)...
  69. Ling Q, Mohite A, Murdoch E, Akasaka H, Li Q, So S, et al. Creating a mouse model resistant to induced ischemic stroke and cardiovascular damage. Sci Rep. 2018;8:1653 pubmed publisher
    ..During endothelial dysfunction, vascular protector prostacyclin/prostaglandin I2 (PGI2) is decreased, while inflammatory PGE2 and thrombotic TXA2 are increased...
  70. Whinna H, Choi H, Rosenberg L, Church F. Interaction of heparin cofactor II with biglycan and decorin. J Biol Chem. 1993;268:3920-4 pubmed
    Two small interstitial dermatan sulfate-containing proteoglycans, biglycan and decorin, are present in extracellular matrices of skin, tendon, ligament, and cartilage...
  71. Inoue A, Hayakawa T, Otsuka E, Kamiya A, Suzuki Y, Hirose S, et al. Correlation between induction of expression of biglycan and mineralization by C-type natriuretic peptide in osteoblastic cells. J Biochem. 1999;125:103-8 pubmed
    ..of mRNA whose level was increased by CNP was 99% homologous to the 3'-untranslated region of a mouse gene for biglycan (BGN), a small proteoglycan. BGN is known to be involved in bone formation by osteoblastic cells...
  72. Mannion S, Mtintsilana A, Posthumus M, van der Merwe W, Hobbs H, Collins M, et al. Genes encoding proteoglycans are associated with the risk of anterior cruciate ligament ruptures. Br J Sports Med. 2014;48:1640-6 pubmed publisher
    ..with ACL injury susceptibility; polymorphisms within genes encoding the proteoglycans aggrecan (ACAN), biglycan (BGN), decorin (DCN), fibromodulin (FMOD) and lumican (LUM) were examined...
  73. Khan F, Syeda P, Nartey M, Rahman M, Islam M, Nishimura K, et al. Pretreatment of cultured preadipocytes with arachidonic acid during the differentiation phase without a cAMP-elevating agent enhances fat storage after the maturation phase. Prostaglandins Other Lipid Mediat. 2016;123:16-27 pubmed publisher
    ..By contrast, the expression levels of COX-1, cytosolic PGE synthase, and PGI synthase remained constitutive...
  74. Scheer J, Keefe M, Lafage V, Kelly M, Bess S, Burton D, et al. Importance of patient-reported individualized goals when assessing outcomes for adult spinal deformity (ASD): initial experience with a Patient Generated Index (PGI). Spine J. 2017;17:1397-1405 pubmed publisher
    ..This study aimed to describe the initial experience of a Patient Generated Index (PGI) in which patients create their own outcome domains. This is a single-center prospective study...
  75. Mallon A, Platzer M, Bate R, Gloeckner G, Botcherby M, Nordsiek G, et al. Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. Genome Res. 2000;10:758-75 pubmed
    ..Surprisingly, this region showed an extremely high LINE and low SINE content, low G+C content, and yet a relatively high gene density, in contrast to the low gene density usually associated with such regions. ..
  76. Roy A, Ganesh G, Sippola H, Bolin S, Sawesi O, Dagälv A, et al. Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation. J Biol Chem. 2014;289:237-50 pubmed publisher
    ..Chymase, but not MC tryptase, also degraded other alarmins, i.e. biglycan, HMGB1, and IL-33, a degradation that was efficiently blocked by the chymase inhibitor chymostatin...
  77. Mandraffino G, Imbalzano E, Mamone F, Aragona C, Lo Gullo A, D Ascola A, et al. Biglycan expression in current cigarette smokers: a possible link between active smoking and atherogenesis. Atherosclerosis. 2014;237:471-9 pubmed publisher
    Cigarette smokers present early signs of vascular damage and systemic inflammation. Biglycan (BGN), an ubiquitous component of extracellular matrix orchestrating several physiological functions, has recently been indicated as a major ..
  78. Hara S. Prostaglandin terminal synthases as novel therapeutic targets. Proc Jpn Acad Ser B Phys Biol Sci. 2017;93:703-723 pubmed publisher
    ..the current understanding of PG terminal synthases, with a focus on microsomal PGE synthase-1 (mPGES-1) and PGI synthase (PGIS)...
  79. Mangelsdorf J. Coping with Childbirth: Brain Structural Associations of Personal Growth Initiative. Front Psychol. 2017;8:1829 pubmed publisher
    ..The goal of the current study was to investigate the association of personal growth initiative (PGI) as a form of proactive coping strategy before childbirth, with gray matter volume after delivery...
  80. Chatterjee A, Faust C, Herman G. Genetic and physical mapping of the biglycan gene on the mouse X chromosome. Mamm Genome. 1993;4:33-6 pubmed
    A human cDNA for biglycan (BGN) has recently been mapped to proximal Xq28...
  81. Li Z, Zou J, Mao K, Lin K, Li H, Liu J, et al. Population genetic evidence for complex evolutionary histories of four high altitude juniper species in the Qinghai-Tibetan Plateau. Evolution. 2012;66:831-845 pubmed publisher
    ..which diverged in response to the extensive QTP uplifts, have different demographic histories; (2) two loci, Pgi and CC0822, depart significantly from neutrality in one species and Pgi, is also marginally significant in another; ..
  82. Mao J, Smoake J, Park H, Lu Q, Xue B. Grape Seed Procyanidin Extract Mediates Antineoplastic Effects against Lung Cancer via Modulations of Prostacyclin and 15-HETE Eicosanoid Pathways. Cancer Prev Res (Phila). 2016;9:925-932 pubmed
    ..carcinogenesis to inflammatory events involving other major eicosanoid metabolic pathways, including prostacyclin (PGI2) and 15-hydroxyeicosatetraenoic acid (15-HETE)...
  83. Beharry K, Cai C, Valencia G, Lazzaro D, Valencia A, Salomone F, et al. Human retinal endothelial cells and astrocytes cultured on 3-D scaffolds for ocular drug discovery and development. Prostaglandins Other Lipid Mediat. 2018;134:93-107 pubmed publisher
    ..HRAs enhanced the responses of HRECs to drugs and changes in oxygen environment. PGE2 and PGI2 were the predominant prostanoids produced in response to IH, reflecting COX-2 immunoreactivity...
  84. Xing Z, Geng W, Li C, Sun Y, Wang Y. Comparative genomics of Lactobacillus kefiranofaciens ZW3 and related members of Lactobacillus. spp reveal adaptations to dairy and gut environments. Sci Rep. 2017;7:12827 pubmed publisher
    ..in the relative expression of pgm, ugp, and uge during the mid-logarithmic phase, whereas the expression of pgi was higher at the beginning of the stationary phase...
  85. Snow A, Kinsella M, Parks E, Sekiguchi R, Miller J, Kimata K, et al. Differential binding of vascular cell-derived proteoglycans (perlecan, biglycan, decorin, and versican) to the beta-amyloid protein of Alzheimer's disease. Arch Biochem Biophys. 1995;320:84-95 pubmed
    ..of EC and SMC PGs bound to A beta (1-28) revealed strong binding by perlecan, weak binding by decorin and biglycan, two dermatan sulfate proteoglycans, and lack of binding by versican/PG-M, a large chondroitin sulfate ..
  86. Mochida Y, Parisuthiman D, Yamauchi M. Biglycan is a positive modulator of BMP-2 induced osteoblast differentiation. Adv Exp Med Biol. 2006;585:101-13 pubmed
  87. Kilts T, Ameye L, Syed Picard F, Ono M, Berendsen A, Oldberg A, et al. Potential roles for the small leucine-rich proteoglycans biglycan and fibromodulin in ectopic ossification of tendon induced by exercise and in modulating rotarod performance. Scand J Med Sci Sports. 2009;19:536-46 pubmed publisher
    We present a detailed comparison of ectopic ossification (EO) found in tendons of biglycan (Bgn), fibromodulin (Fmod) single and double Bgn/Fmod-deficient (DKO) mice with aging...
  88. Sardo M, Mandraffino G, Campo S, Saitta C, Bitto A, Alibrandi A, et al. Biglycan expression in hypertensive subjects with normal or increased carotid intima-media wall thickness. Clin Chim Acta. 2009;406:89-93 pubmed publisher
    b>Biglycan (BGN), an extracellular matrix proteoglycan, has been shown to convey pro-inflammatory signals...
  89. Ward M, Ajuwon K. Regulation of pre-adipocyte proliferation and apoptosis by the small leucine-rich proteoglycans, biglycan and decorin. Cell Prolif. 2011;44:343-51 pubmed publisher
    ..Pre-adipocytes were seeded on plates coated with biglycan and decorin and were allowed to differentiate...
  90. Berendsen A, Pinnow E, Maeda A, Brown A, McCartney Francis N, Kram V, et al. Biglycan modulates angiogenesis and bone formation during fracture healing. Matrix Biol. 2014;35:223-31 pubmed publisher
    Matrix proteoglycans such as biglycan (Bgn) dominate skeletal tissue and yet its exact role in regulating bone function is still unclear. In this paper we describe the potential role of (Bgn) in the fracture healing process...
  91. Nenoff L, Priegnitz M, Janssens G, Petzoldt J, Wohlfahrt P, Trezza A, et al. Sensitivity of a prompt-gamma slit-camera to detect range shifts for proton treatment verification. Radiother Oncol. 2017;125:534-540 pubmed publisher
    A prompt-gamma imaging (PGI) slit-camera was recently applied successfully in clinical proton treatments using pencil beam scanning (PBS) and double scattering (DS)...
  92. Fujisawa R. [Recent advances in research on bone matrix proteins]. Nihon Rinsho. 2002;60 Suppl 3:72-8 pubmed