Bid

Summary

Gene Symbol: Bid
Description: BH3 interacting domain death agonist
Alias: FP497, BH3-interacting domain death agonist, BH3 interacting domain death agonist Si6 isoform, BID isoform ES(1b), BID isoform L(2), BID isoform Si6, Human BID coding sequence, apoptic death agonist, desmocollin type 4, p22 BID
Species: human
Products:     Bid

Top Publications

  1. Oh K, Barbuto S, Meyer N, Kim R, Collier R, Korsmeyer S. Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding. A site-directed spin labeling study. J Biol Chem. 2005;280:753-67 pubmed
    ..the site-directed spin labeling method of electron paramagnetic resonance spectroscopy to the pro-apoptotic member BID. Here we show that helices 6-8 maintain an alpha-helical conformation in membranes with a lipid composition ..
  2. Denisov A, Chen G, Sprules T, Moldoveanu T, Beauparlant P, Gehring K. Structural model of the BCL-w-BID peptide complex and its interactions with phospholipid micelles. Biochemistry. 2006;45:2250-6 pubmed
    A peptide corresponding to the BH3 region of the proapoptotic protein, BID, could be bound in the cleft of the antiapoptotic protein, BCL-w...
  3. Seenath M, Roberts D, Cawthorne C, Saunders M, Armstrong G, O Dwyer S, et al. Reciprocal relationship between expression of hypoxia inducible factor 1alpha (HIF-1alpha) and the pro-apoptotic protein bid in ex vivo colorectal cancer. Br J Cancer. 2008;99:459-63 pubmed publisher
    Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro...
  4. Schug Z, Gonzalvez F, Houtkooper R, Vaz F, Gottlieb E. BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane. Cell Death Differ. 2011;18:538-48 pubmed publisher
    ..In this study, we have identified a native complex containing caspase-8 and BID on the mitochondrial membrane, and showed that death receptor activation by Fas or tumor necrosis factor-related ..
  5. Willis S, Fletcher J, Kaufmann T, van Delft M, Chen L, Czabotar P, et al. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science. 2007;315:856-9 pubmed
    ..that Bax and Bak can mediate apoptosis without discernable association with the putative BH3-only activators (Bim, Bid, and Puma), even in cells with no Bim or Bid and reduced Puma...
  6. Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell. 1998;94:481-90 pubmed
    ..Peptide mass fingerprinting identified this protein as Bid, a BH3 domain-containing protein known to interact with both Bcl2 and Bax...
  7. Shamas Din A, Bindner S, Zhu W, Zaltsman Y, Campbell C, Gross A, et al. tBid undergoes multiple conformational changes at the membrane required for Bax activation. J Biol Chem. 2013;288:22111-27 pubmed publisher
    b>Bid is a Bcl-2 family protein that promotes apoptosis by activating Bax and eliciting mitochondrial outer membrane permeabilization (MOMP)...
  8. García Sáez A, Mingarro I, Perez Paya E, Salgado J. Membrane-insertion fragments of Bcl-xL, Bax, and Bid. Biochemistry. 2004;43:10930-43 pubmed
    ..on the membrane-insertion properties of different segments from antiapoptotic Bcl-x(L) and proapoptotic Bax and Bid, that correspond to defined alpha helices in the structure of their soluble forms...
  9. Degli Esposti M, Ferry G, Masdehors P, Boutin J, Hickman J, Dive C. Post-translational modification of Bid has differential effects on its susceptibility to cleavage by caspase 8 or caspase 3. J Biol Chem. 2003;278:15749-57 pubmed
    b>Bid is instrumental in death receptor-mediated apoptosis where it is cleaved by caspase 8 at aspartate 60 and aspartate 75 to generate truncated Bid (tBID) forms that facilitate release of mitochondrial cytochrome c...

More Information

Publications76

  1. Roucou X, Montessuit S, Antonsson B, Martinou J. Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein. Biochem J. 2002;368:915-21 pubmed
    ..be induced by incubating isolated mitochondria containing endogenous Bax with recombinant tBid (caspase-8-cleaved Bid) in vitro. The mechanism by which Bax oligomerizes under these conditions is still unknown...
  2. Tait S, de Vries E, Maas C, Keller A, D Santos C, Borst J. Apoptosis induction by Bid requires unconventional ubiquitination and degradation of its N-terminal fragment. J Cell Biol. 2007;179:1453-66 pubmed publisher
    Bcl-2 family member Bid is subject to autoinhibition; in the absence of stimuli, its N-terminal region sequesters the proapoptotic Bcl-2 homology 3 (BH3) domain...
  3. Erler J, Cawthorne C, Williams K, Koritzinsky M, Wouters B, Wilson C, et al. Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. Mol Cell Biol. 2004;24:2875-89 pubmed
    ..Oxygen deprivation of human colon cancer cells in vitro provoked decreased mRNA and protein levels of proapoptotic Bid and Bad...
  4. Gabai V, Mabuchi K, Mosser D, Sherman M. Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis. Mol Cell Biol. 2002;22:3415-24 pubmed
    ..In fibroblasts derived from Bid knockout mice, similar temporal inhibition of TNF-induced apoptosis was seen...
  5. Czabotar P, Westphal D, Dewson G, Ma S, Hockings C, Fairlie W, et al. Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis. Cell. 2013;152:519-31 pubmed publisher
    ..A planar lipophilic surface on this homodimer may engage the membrane. Our results thus define critical Bax transitions toward apoptosis. ..
  6. Eskes R, Desagher S, Antonsson B, Martinou J. Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane. Mol Cell Biol. 2000;20:929-35 pubmed
    ..Here we show that following binding to the BH3-domain-only proapoptotic protein Bid, Bax oligomerizes and then integrates in the outer mitochondrial membrane, where it triggers cytochrome c release...
  7. Werner A, de Vries E, Tait S, Bontjer I, Borst J. Bcl-2 family member Bfl-1/A1 sequesters truncated bid to inhibit is collaboration with pro-apoptotic Bak or Bax. J Biol Chem. 2002;277:22781-8 pubmed
    Following caspase-8 mediated cleavage, a carboxyl-terminal fragment of the BH3 domain-only Bcl-2 family member Bid transmits the apoptotic signal from death receptors to mitochondria...
  8. Kuwana T, Mackey M, Perkins G, Ellisman M, Latterich M, Schneiter R, et al. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell. 2002;111:331-42 pubmed
    ..b>Bid, or its BH3-domain peptide, activated monomeric Bax to produce membrane openings that allowed the passage of very ..
  9. Renshaw S, Dempsey C, Barnes F, Bagstaff S, Dower S, Bingle C, et al. Three novel Bid proteins generated by alternative splicing of the human Bid gene. J Biol Chem. 2004;279:2846-55 pubmed
    b>Bid, a BH3-only Bcl-2 protein, is activated by proteolytic cleavage exposing the BH3 domain, which then induces apoptosis by interacting with pro-apoptotic Bcl-2 family proteins (e.g. Bax and Bak) at the mitochondrial surface...
  10. Ku B, Liang C, Jung J, Oh B. Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX. Cell Res. 2011;21:627-41 pubmed publisher
    ..for BCL-2, BCL-w and A1, and of BAK for BCL-X(L), MCL-1 and A1, only a subset of BH3-only proteins, commonly including BIM, BID and PUMA, could be expected to free BAX or BAK from the antiapoptotic BCL-2 proteins to elicit apoptosis.
  11. Desagher S, Osen Sand A, Montessuit S, Magnenat E, Vilbois F, Hochmann A, et al. Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8. Mol Cell. 2001;8:601-11 pubmed
    b>Bid plays an essential role in Fas-mediated apoptosis of the so-called type II cells...
  12. Azakir B, Desrochers G, Angers A. The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid. FEBS J. 2010;277:1319-30 pubmed publisher
    The truncated C-terminal portion of Bid (tBid) is an important intermediate in ligand-induced apoptosis...
  13. Tafani M, Karpinich N, Hurster K, Pastorino J, Schneider T, Russo M, et al. Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition. J Biol Chem. 2002;277:10073-82 pubmed
    In Jurkat cells Bid was cleaved upon activation of the Fas receptor with an anti-Fas antibody. The caspase-8 inhibitor benzyloxycarbonyl-Ile-Glu(OMe)-Thr-Asp(OMe)-CH(2)F (IETD) prevented the cleavage of Bid and the loss of viability...
  14. Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk J, Kuwana T. BH3 domains other than Bim and Bid can directly activate Bax/Bak. J Biol Chem. 2011;286:491-501 pubmed publisher
    ..They do so by neutralizing pro-survival Bcl-2 proteins and/or directly activating Bax/Bak. Bim and Bid are reported to be direct activators; however, here we show that BH3 peptides other than Bim and Bid exhibited ..
  15. Cheng E, Wei M, Weiler S, Flavell R, Mak T, Lindsten T, et al. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell. 2001;8:705-11 pubmed
    ..Thus, in mammals, BH3 domain-only molecules activate multidomain proapoptotic members to trigger a mitochondrial pathway, which both releases cytochrome c to activate caspases and initiates caspase-independent mitochondrial dysfunction. ..
  16. Walensky L, Kung A, Escher I, Malia T, Barbuto S, Wright R, et al. Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science. 2004;305:1466-70 pubmed
    ..A SAHB of the BH3 domain from the BID protein specifically activated the apoptotic pathway to kill leukemia cells...
  17. Sutton V, Davis J, Cancilla M, Johnstone R, Ruefli A, Sedelies K, et al. Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation. J Exp Med. 2000;192:1403-14 pubmed
    ..Herein, we show that granzyme B triggers the mitochondrial apoptotic pathway through direct cleavage of Bid; however, cleavage of procaspases was stalled when mitochondrial disruption was blocked by Bcl-2...
  18. Zhang H, Fang D, Wang R, Yang S, Liu H, Luo Y. Effect of Helicobacter pylori infection on expression of Bcl-2 family members in gastric adenocarcinoma. World J Gastroenterol. 2004;10:227-30 pubmed
    ..Semi-quantitative RT-PCR was used to measure Bid, Bax and Bcl-2 mRNA expressions...
  19. Billen L, Shamas Din A, Andrews D. Bid: a Bax-like BH3 protein. Oncogene. 2008;27 Suppl 1:S93-104 pubmed publisher
    b>Bid, a pro-apoptotic member of the Bcl-2 family, was initially discovered through binding to both pro-apoptotic Bax and anti-apoptotic Bcl-2...
  20. Certo M, Del Gaizo Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong S, et al. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell. 2006;9:351-65 pubmed
    ..Dependence on antiapoptotic proteins correlates with sequestration of activator BH3-only proteins like BID or BIM by antiapoptotic proteins...
  21. Zha J, Weiler S, Oh K, Wei M, Korsmeyer S. Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis. Science. 2000;290:1761-5 pubmed
    Many apoptotic molecules relocate subcellularly in cells undergoing apoptosis. The pro-apoptotic protein BID underwent posttranslational (rather than classic cotranslational) N-myristoylation when cleavage by caspase 8 caused exposure of ..
  22. Cirman T, Oresic K, Mazovec G, Turk V, Reed J, Myers R, et al. Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. J Biol Chem. 2004;279:3578-87 pubmed
    ..by translocation of lysosomal proteases into the cytosol and by the cleavage of a proapoptotic Bcl-2-family member Bid. Apoptosis and Bid cleavage, but not translocation of lysosomal proteases to the cytosol, could be prevented by 15 ..
  23. Mandic A, Viktorsson K, Strandberg L, Heiden T, Hansson J, Linder S, et al. Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis. Mol Cell Biol. 2002;22:3003-13 pubmed
    ..Furthermore, cisplatin induced cleavage of the BH3-only protein Bid, yielding a 14-kDa fragment similar to proapoptotic, caspase-cleaved Bid...
  24. Hu X, Han Z, Wyche J, Hendrickson E. Helix 6 of tBid is necessary but not sufficient for mitochondrial binding activity. Apoptosis. 2003;8:277-89 pubmed
    The apoptosis effector Bid regulates cell death at the level of mitochondrial cytochrome c efflux. Bid consists of 8 alpha-helices (designated H1 through H8, respectively) and is a soluble cytosolic protein in its native state...
  25. Wei M, Lindsten T, Mootha V, Weiler S, Gross A, Ashiya M, et al. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev. 2000;14:2060-71 pubmed
    TNFR1/Fas engagement results in the cleavage of cytosolic BID to truncated tBID, which translocates to mitochondria. Immunodepletion and gene disruption indicate BID is required for cytochrome c release...
  26. Shelton S, Shawgo M, Robertson J. Cleavage of Bid by executioner caspases mediates feed forward amplification of mitochondrial outer membrane permeabilization during genotoxic stress-induced apoptosis in Jurkat cells. J Biol Chem. 2009;284:11247-55 pubmed publisher
    The extent to which the BH3-only protein Bid is important for intrinsic (mitochondria-mediated) apoptotic cell death induced by genotoxic stress remains controversial...
  27. Aoyagi M, Zhai D, Jin C, Aleshin A, Stec B, Reed J, et al. Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein. Protein Sci. 2007;16:118-24 pubmed
  28. Madesh M, Antonsson B, Srinivasula S, Alnemri E, Hajnoczky G. Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization. J Biol Chem. 2002;277:5651-9 pubmed
    Cleavage of Bid has been shown to promote apoptosis by inducing mitochondrial membrane permeabilization with the resultant release of apoptosis-inducing proteins from the intermembrane space into the cytosol...
  29. Garcia Perez C, Roy S, Naghdi S, Lin X, Davies E, Hajnoczky G. Bid-induced mitochondrial membrane permeabilization waves propagated by local reactive oxygen species (ROS) signaling. Proc Natl Acad Sci U S A. 2012;109:4497-502 pubmed publisher
    b>Bid-induced mitochondrial membrane permeabilization and cytochrome c release are central to apoptosis...
  30. Wang Y, Tjandra N. Structural insights of tBid, the caspase-8-activated Bid, and its BH3 domain. J Biol Chem. 2013;288:35840-51 pubmed publisher
    ..Compared with the full-length Bid structure, a longer flexible loop between tBid helix ?4 and ?5 was observed...
  31. Wang K, Yin X, Chao D, Milliman C, Korsmeyer S. BID: a novel BH3 domain-only death agonist. Genes Dev. 1996;10:2859-69 pubmed
    ..To extend this pathway, we used interactive cloning to identify Bid, which encodes a novel death agonist that heterodimerizes with either agonists (BAX) or antagonists (BCL-2)...
  32. Chen L, Willis S, Wei A, Smith B, Fletcher J, Hinds M, et al. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell. 2005;17:393-403 pubmed
    ..The results suggest that apoptosis relies on selective interactions between particular subsets of these proteins and that it should be feasible to discover BH3-mimetic drugs that inactivate specific prosurvival targets. ..
  33. Gong X, Choi J, Franzin C, Zhai D, Reed J, Marassi F. Conformation of membrane-associated proapoptotic tBid. J Biol Chem. 2004;279:28954-60 pubmed
    The proapoptotic Bcl-2 family protein Bid is cleaved by caspase-8 to release the C-terminal fragment tBid, which translocates to the outer mitochondrial membrane and induces massive cytochrome c release and cell death...
  34. Grinberg M, Sarig R, Zaltsman Y, Frumkin D, Grammatikakis N, Reuveny E, et al. tBID Homooligomerizes in the mitochondrial membrane to induce apoptosis. J Biol Chem. 2002;277:12237-45 pubmed
    Activation of the tumor necrosis factor R1/Fas receptor results in the cleavage of cytosolic BID to truncated tBID...
  35. Alimonti J, Shi L, Baijal P, Greenberg A. Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition. J Biol Chem. 2001;276:6974-82 pubmed
    ..The cleavage of cytosolic BID by GrB results in truncated BID, initiating mitochondrial cyt c release...
  36. Esposti M, Erler J, Hickman J, Dive C. Bid, a widely expressed proapoptotic protein of the Bcl-2 family, displays lipid transfer activity. Mol Cell Biol. 2001;21:7268-76 pubmed
    b>Bid is an abundant proapoptotic protein of the Bcl-2 family that is crucial for the induction of death receptor-mediated apoptosis in primary tissues such as liver...
  37. Chou J, Li H, Salvesen G, Yuan J, Wagner G. Solution structure of BID, an intracellular amplifier of apoptotic signaling. Cell. 1999;96:615-24 pubmed
    We report the solution structure of BID, an intracellular cross-talk agent that can amplify FAS/TNF apoptotic signal through the mitochondria death pathway after Caspase 8 cleavage...
  38. Li H, Zhu H, Xu C, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 1998;94:491-501 pubmed
    We report here that BID, a BH3 domain-containing proapoptotic Bcl2 family member, is a specific proximal substrate of Casp8 in the Fas apoptotic signaling pathway...
  39. García Sáez A, Ries J, Orzáez M, Perez Paya E, Schwille P. Membrane promotes tBID interaction with BCL(XL). Nat Struct Mol Biol. 2009;16:1178-85 pubmed publisher
    ..correlation spectroscopy to quantify the molecular interactions of BH3-interacting domain death agonist (BID) and its truncated form tBID with the B cell lymphoma extra-large protein truncated at the C terminus (BCL(XL)..
  40. Niioka T, Kagaya H, Saito M, Inoue T, Numakura K, Yamamoto R, et al. Impact of the CYP3A5 genotype on the distributions of dose-adjusted trough concentrations and incidence of rejection in Japanese renal transplant recipients receiving different tacrolimus formulations. Clin Exp Nephrol. 2017;21:787-796 pubmed publisher
    ..concentrations (C 0h/D) and the incidence of rejection in Japanese recipients taking twice-daily (Tac-BID, n?=?140) or modified-release once-daily (Tac-QD, n?=?80) tacrolimus formulations for 1 year after renal ..
  41. Xu F, Ren L, Song M, Shao B, Han Y, Cao Z, et al. Fas- and Mitochondria-Mediated Signaling Pathway Involved in Osteoblast Apoptosis Induced by AlCl3. Biol Trace Elem Res. 2018;184:173-185 pubmed publisher
    ..and Fas-associated death domain expression enhancement and caspase-8 activation, as well as the hydrolysis of Bid to truncated Bid, suggesting that the Fas-mediated signaling pathway might aggravate mitochondria-mediated OB ..
  42. Lee H, Shin J, Jeong J, Jeon J, Lee M, Cho S. Anticancer activity of Ashwagandha against human head and neck cancer cell lines. J Oral Pathol Med. 2016;45:193-201 pubmed publisher
    ..Knockdown of Bim by siRNA partially blocked MEAG-mediated apoptosis. MEAG also caused an increase in truncated Bid (t-Bid), cleaved caspase-8, and death receptor 5 (DR5)...
  43. Dalbøge L, Pedersen P, Hansen G, Fabricius K, Hansen H, Jelsing J, et al. A Hamster Model of Diet-Induced Obesity for Preclinical Evaluation of Anti-Obesity, Anti-Diabetic and Lipid Modulating Agents. PLoS ONE. 2015;10:e0135634 pubmed publisher
    ..Chronic treatment with the GLP-1 analogue, liraglutide (0.2 mg/kg, SC, BID, 27 days), normalized body weight and glucose tolerance, and lowered blood lipids in the DIO-hamster...
  44. Venkatakrishnan K, Kim T, Lin C, Thye L, Chng W, Ma B, et al. Phase 1 study of the investigational Aurora A kinase inhibitor alisertib (MLN8237) in East Asian cancer patients: pharmacokinetics and recommended phase 2 dose. Invest New Drugs. 2015;33:942-53 pubmed publisher
    ..Patients received alisertib twice-daily (BID) for 7 days in 21-day cycles...
  45. Babalis D, Tritakis V, Floros G, Mouzarou A, Kafkas N, Bampali K, et al. Effects of ranolazine on left ventricular diastolic and systolic function in patients with chronic coronary disease and stable angina. Hellenic J Cardiol. 2015;56:237-41 pubmed
    ..Patients were randomized to the ranolazine group (group A, 20 patients taking oral ranolazine 500 mg bid for 3 months) and the control group (group B, 20 patients who did not receive the drug)...
  46. Perroud H, Alasino C, Rico M, Mainetti L, Queralt F, Pezzotto S, et al. Metastatic breast cancer patients treated with low-dose metronomic chemotherapy with cyclophosphamide and celecoxib: clinical outcomes and biomarkers of response. Cancer Chemother Pharmacol. 2016;77:365-74 pubmed publisher
    ..Patients received Cy (50 mg po.d) + Cel (200 mg p.o.bid)...
  47. Sanchez R, St Cyr J, Lalonde M, Healy J, Richer C, Gagné V, et al. Impact of promoter polymorphisms in key regulators of the intrinsic apoptosis pathway on the outcome of childhood acute lymphoblastic leukemia. Haematologica. 2014;99:314-21 pubmed publisher
    ..assays, we show that promoter variations in 11 intrinsic apoptosis genes, including ADPRT, APAF1, BCL2, BAD, BID, MCL1, BIRC4, BCL2L1, ENDOG, YWHAB, and YWHAQ, influence promoter activity in an allele-specific manner...
  48. Bai S, Xiang Q, Finn A. Evaluation of the Pharmacokinetics of Single- and Multiple-dose Buprenorphine Buccal Film in Healthy Volunteers. Clin Ther. 2016;38:358-69 pubmed publisher
    ..In the second study, each subject (n = 10) received 6 doses of 4 BBUP strengths (60, 120, 180, and 240 μg BID) in a dose-escalation design...
  49. Helmer E, Watling M, Jones E, Tytgat D, Jones M, Allen R, et al. First-in-human studies of seletalisib, an orally bioavailable small-molecule PI3Kδ inhibitor for the treatment of immune and inflammatory diseases. Eur J Clin Pharmacol. 2017;73:581-591 pubmed publisher
    ..studies (NCT02303509, NCT02207595) evaluated single and multiple oral doses of seletalisib (5-90 mg QD and 30 mg BID) in healthy adults and subjects with mild-to-moderate psoriasis (Study-1)...
  50. Hathaichoti S, Visitnonthachai D, Ngamsiri P, Niyomchan A, Tsogtbayar O, Wisessaowapak C, et al. Paraquat induces extrinsic pathway of apoptosis in A549 cells by induction of DR5 and repression of anti-apoptotic proteins, DDX3 and GSK3 expression. Toxicol In Vitro. 2017;42:123-129 pubmed publisher
    ..Here we demonstrated that PQ caused apoptosis in A549 cells. PQ increased cleavage of caspase-8 and Bid, indicating caspase-8 activation and truncated Bid, the two key mediators of extrinsic apoptosis...
  51. Lee C, Yen F, Ko H, Li S, Chiang Y, Lee M, et al. Cudraflavone C Induces Apoptosis of A375.S2 Melanoma Cells through Mitochondrial ROS Production and MAPK Activation. Int J Mol Sci. 2017;18: pubmed publisher
    ..phosphorylation of MAPKs (p38, ERK, and JNK) and up-regulated the expression of apoptotic proteins (Puma, Bax, Bad, Bid, Apaf-1, cytochrome C, caspase-9, and caspase-3/7) in A375.S2 cells. Pretreatment of A375...
  52. Etxebarria A, Terrones O, Yamaguchi H, Landajuela A, Landeta O, Antonsson B, et al. Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements. J Biol Chem. 2009;284:4200-12 pubmed publisher
  53. Kawamura K, Watanabe K, Suzuki T, Yamakawa T, Kamiyama T, Nakagawa H, et al. cDNA cloning and expression of a novel human desmocollin. J Biol Chem. 1994;269:26295-302 pubmed
    ..These findings suggest that our clone might be a new member of the desmocollin family, and we have tentatively called this clone human desmocollin type 4.
  54. Wang J, Guan E, Roderiquez G, Norcross M. Synergistic induction of apoptosis in primary CD4(+) T cells by macrophage-tropic HIV-1 and TGF-beta1. J Immunol. 2001;167:3360-6 pubmed
    ..with reduced levels of Bcl-2 and increased expression of apoptosis-inducing factor, caspase-3, and cleavage of BID, c-IAP-1, and X-linked inhibitor of apoptosis...
  55. Flores Cornejo F, Kamego Tome M, Zapata Pachas M, Alvarado G. Association between body image dissatisfaction and depressive symptoms in adolescents. Braz J Psychiatry. 2017;39:316-322 pubmed publisher
    To determine the association between body image dissatisfaction (BID) and depressive symptoms in adolescents from a school in Lima, Peru...
  56. Zhao Y, Li R, Xia W, Neuzil J, Lu Y, Zhang H, et al. Bid integrates intrinsic and extrinsic signaling in apoptosis induced by alpha-tocopheryl succinate in human gastric carcinoma cells. Cancer Lett. 2010;288:42-9 pubmed publisher
    ..Bax was translocated from the cytosol to mitochondria and Bid was cleaved into its truncated form, tBid...
  57. Miles J, Yeo D, Rowell P, Rodriguez Marin S, Pask C, Warriner S, et al. Hydrocarbon constrained peptides - understanding preorganisation and binding affinity. Chem Sci. 2016;7:3694-3702 pubmed publisher
    ..of a novel α-alkenylglycine derived amino acid to synthesise hydrocarbon constrained BH3-family sequences (BIM and BID)...
  58. Lamparska Przybysz M, Gajkowska B, Motyl T. Cathepsins and BID are involved in the molecular switch between apoptosis and autophagy in breast cancer MCF-7 cells exposed to camptothecin. J Physiol Pharmacol. 2005;56 Suppl 3:159-79 pubmed
    ..This study focused on the role of cathepsin B and its substrate, BID as molecular links between apoptosis and autophagy in human breast cancer MCF-7 cells exposed to camptothecin...
  59. Müer A, Overkamp T, Gillissen B, Richter A, Pretzsch T, Milojkovic A, et al. p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins. J Biol Chem. 2012;287:17343-52 pubmed publisher
    ..Moreover, our data suggest that the simultaneous inhibition of two central endogenous Bak inhibitors, i.e. Mcl-1 and Bcl-x(L), may be sufficient to activate mitochondrial apoptosis in the absence of BH3-only protein regulation. ..
  60. Shinoda S, Schindler C, Quan Lan J, Saugstad J, Taki W, Simon R, et al. Interaction of 14-3-3 with Bid during seizure-induced neuronal death. J Neurochem. 2003;86:460-9 pubmed
    ..BH3-interacting domain death agonist (Bid) may contribute to seizure-induced neuronal death, although regulation by 14-3-3 has not been reported...
  61. Fujimoto J, Hirayama T, Hirata Y, Hikichi Y, Murai S, Hasegawa M, et al. Studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential. Bioorg Med Chem. 2017;25:3018-3033 pubmed publisher
    ..Oral administration of 4k (15mg/kg, bid. for 2weeks) suppressed tumor growth (T/C 29%) in an RPMI8226 mouse xenograft model.
  62. Hung C, Liu L, Ho C, Lin Y, Way T. Pterostilbene enhances TRAIL-induced apoptosis through the induction of death receptors and downregulation of cell survival proteins in TRAIL-resistance triple negative breast cancer cells. J Agric Food Chem. 2017;: pubmed publisher
    ..PTER caused the cleavage of bid protein and enhanced the expression of pro-apoptotic Bax...
  63. Bor S, Kalkan I. Medical treatment of gastroesophageal reflux disease. Turk J Gastroenterol. 2017;28:S48-S52 pubmed publisher
    ..therapy of patients with severe esophagitis (Los Angeles (LA) Grade C-D), administration of a standard dose of PPIs bid has been reported to be more beneficial than PPIs qd...
  64. Jones P, Leidy N, Hareendran A, Lamarca R, Chuecos F, Garcia Gil E. The effect of aclidinium bromide on daily respiratory symptoms of COPD, measured using the Evaluating Respiratory Symptoms in COPD (E-RS: COPD) diary: pooled analysis of two 6-month Phase III studies. Respir Res. 2016;17:61 pubmed publisher
    ..We evaluated the effect of aclidinium bromide 400 μg twice daily (BID) on respiratory symptoms, assessed using the Evaluating Respiratory Symptoms in COPD (E-RS(™): COPD) scale (..
  65. Calvani N, Orlando L, Nacci A, Sponziello F, Cinefra M, Cinieri S. Metronomic chemotherapy against cancer: from paradigm to clinical practice?. Tumori. 2009;95:843-5 pubmed
    ..She received oral cyclophosphamide 50 mg once daily and methotrexate 2.5 mg bid twice weekly, obtaining a significant clinical response with a progression-free survival of 7 months...
  66. He L, Wang H, Luo L, Li Y, Huang R, Liao L, et al. Bid-deficient fish delay grass carp reovirus (GCRV) replication and attenuate GCRV-triggered apoptosis. Oncotarget. 2017;8:76408-76422 pubmed publisher
    b>Bid, BH3-interacting domain death agonist, is a pro-apoptotic BH3-only member of Bcl-2 family, playing an important role in apoptosis...
  67. Sukkha S, Chindavijak B, Montakantikul P, Ingsathit A, Nosoongnoen W, Sumethkul V. Trough level from twice daily to once daily tacrolimus in early conversion kidney transplant recipients: a prospective study. Int J Clin Pharm. 2017;39:1298-1303 pubmed publisher
    Background Early conversion from twice-daily tacrolimus (TAC-BID) to once-daily tacrolimus (TAC-OD) provides a greater benefit of reducing under-exposure of TAC-OD during the first period after transplantation...