Gene Symbol: BICD1
Description: BICD cargo adaptor 1
Alias: BICD, protein bicaudal D homolog 1, bic-D 1, bicaudal D homolog 1, cytoskeleton-like bicaudal D protein homolog 1
Species: human
Products:     BICD1

Top Publications

  1. Wanschers B, van de Vorstenbosch R, Schlager M, Splinter D, Akhmanova A, Hoogenraad C, et al. A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells. Exp Cell Res. 2007;313:3408-20 pubmed
    ..We conclude from our data that the brain-specific Rab6B via Bicaudal-D1 is linked to the dynein/dynactin complex, suggesting a regulatory role for Rab6B in the retrograde transport of cargo in neuronal cells. ..
  2. Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr F. The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes. Curr Biol. 2002;12:1792-5 pubmed
    ..Other Golgi Rabs do not bind to dynactin and are unable to support its recruitment to membranes. Rab6 therefore functions as a specificity or tethering factor controlling the recruitment of dynactin to membranes. ..
  3. Matanis T, Akhmanova A, Wulf P, del Nery E, Weide T, Stepanova T, et al. Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. Nat Cell Biol. 2002;4:986-92 pubmed
    ..In particular, we identified the dynein-dynactin-binding protein Bicaudal-D1 (BICD1), one of the two mammalian homologues of Drosophila Bicaudal-D...
  4. Mangino M, Brouilette S, Braund P, Tirmizi N, Vasa Nicotera M, Thompson J, et al. A regulatory SNP of the BICD1 gene contributes to telomere length variation in humans. Hum Mol Genet. 2008;17:2518-23 pubmed publisher
    ..3). Fine-mapping identified a 51 kb region of association within intron 1 of the Bicaudal-D homolog 1 (BICD1, MIM 602204) gene. The strongest association (P = 1...
  5. Lee H, Jung Y, Oh J, Choi G, Chae C, Kim J, et al. BICD1 mediates HIF1α nuclear translocation in mesenchymal stem cells during hypoxia adaptation. Cell Death Differ. 2018;: pubmed publisher
    ..Here, we investigated the role of a motor adaptor protein Bicaudal D homolog 1 (BICD1) in dynein-mediated HIF1α nuclear translocation and the effect of BICD1 regulation on hypoxia ..
  6. Suter B. RNA localization and transport. Biochim Biophys Acta Gene Regul Mech. 2018;1861:938-951 pubmed publisher
    ..studies have contributed to the enormous recent progress, particularly in understanding how dynein/dynactin/BicD (DDB) dependent transport on microtubules works...
  7. McClintock M, Dix C, Johnson C, McLaughlin S, Maizels R, Hoang H, et al. RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs. elife. 2018;7: pubmed publisher
    ..We have reconstituted microtubule minus end-directed transport of mRNAs using purified components. A Bicaudal-D (BicD) adaptor protein and the RNA-binding protein Egalitarian (Egl) are sufficient for long-distance mRNA transport by ..
  8. Sladewski T, Billington N, Ali M, Bookwalter C, Lu H, Krementsova E, et al. Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex. elife. 2018;7: pubmed publisher
    We investigated the role of full-length Drosophila Bicaudal D (BicD) binding partners in dynein-dynactin activation for mRNA transport on microtubules...
  9. Terawaki S, Yoshikane A, Higuchi Y, Wakamatsu K. Structural basis for cargo binding and autoinhibition of Bicaudal-D1 by a parallel coiled-coil with homotypic registry. Biochem Biophys Res Commun. 2015;460:451-6 pubmed publisher
    Bicaudal-D1 (BICD1) is an α-helical coiled-coil protein mediating the attachment of specific cargo to cytoplasmic dynein. It plays an essential role in minus end-directed intracellular transport along microtubules...

More Information


  1. Lee J, Cho M, McDonald M, Hersh C, Castaldi P, Crapo J, et al. Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene. Respir Med. 2014;108:1469-80 pubmed publisher
    ..The emphysema-predominant GOLD 1 cluster was nominally associated with rs7671167 (FAM13A) and rs161976 (BICD1). The lowest FEV1% predicted cluster was nominally associated with rs1980057 (HHIP) and rs1051730 (CHRNA3)...
  2. Chen Y, Jiang C, Jin M, Gong Y, Zhang X. The role of Rab6 GTPase in the maturation of phagosome against Staphylococcus aureus. Int J Biochem Cell Biol. 2015;61:35-44 pubmed publisher
    ..It was revealed that Rab6 GTPase was required during the phagosome maturation by its interaction with bicaudal-D1 (BICD1) protein...
  3. Schlager M, Serra Marques A, Grigoriev I, Gumy L, Esteves da Silva M, Wulf P, et al. Bicaudal d family adaptor proteins control the velocity of Dynein-based movements. Cell Rep. 2014;8:1248-56 pubmed publisher
    ..We also find that Bicaudal D (BICD) adaptor proteins can regulate dynein-based vesicle motility...
  4. Kłoda K, Domanski L, Kwiatkowska E, Safranow K, Drozd A, Ciechanowicz A, et al. Kidney Allograft Telomere Length Is Not Associated with Sex, Recipient Comorbid Conditions, Post-Transplant Infections, or CMV Reactivation. Ann Transplant. 2016;21:392-9 pubmed
    ..Additionally, the associations of donor and recipient hTERT, BICD1 genes and chromosome 18 polymorphisms with post-transplant infections were analyzed, including the analysis of ..
  5. Vazquez Pianzola P, Schaller B, Colombo M, Beuchle D, Neuenschwander S, Marcil A, et al. The mRNA transportome of the BicD/Egl transport machinery. RNA Biol. 2017;14:73-89 pubmed publisher
    ..b>BicD and the mRNA binding protein Egl interact with the microtubule motor dynein to localize mRNAs in Drosophila...
  6. Kong X, Cho M, Anderson W, Coxson H, Muller N, Washko G, et al. Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema. Am J Respir Crit Care Med. 2011;183:43-9 pubmed publisher
    ..we identified association of a single-nucleotide polymorphism in BICD1 with the presence or absence of emphysema (P = 5.2 × 10(-7) with at least mild emphysema vs...
  7. Swift S, Xu J, Trivedi V, Austin K, Tressel S, Zhang L, et al. A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization. J Biol Chem. 2010;285:11402-10 pubmed publisher
    ..Using a yeast two-hybrid screen, we identified Bicaudal D1 (BicD1) as a direct interactor with the C-terminal cytoplasmic domain of PAR1...
  8. Fuchs E, Haas A, Spooner R, Yoshimura S, Lord J, Barr F. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. J Cell Biol. 2007;177:1133-43 pubmed
    ..These results suggest that Shiga toxin trafficking to the Golgi is a multistep process controlled by several Rab GAPs and their target Rabs and that this process is discrete from ligand-induced EGF receptor trafficking. ..
  9. Johansson A, Marroni F, Hayward C, Franklin C, Kirichenko A, Jonasson I, et al. Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene. Obesity (Silver Spring). 2010;18:803-8 pubmed publisher
    ..The analysis enabled us to identify a new candidate gene, MGAT1, associated with weight in women. ..
  10. Baens M, Aerssens J, Van Zand K, Van den Berghe H, Marynen P. Isolation and regional assignment of human chromosome 12p cDNAs. Genomics. 1995;29:44-52 pubmed
    ..Evidence was found for the duplication on 12p of a region containing a polymorphic simple sequence repeat and sequences of two different cDNAs. ..
  11. Loschi M, Leishman C, Berardone N, Boccaccio G. Dynein and kinesin regulate stress-granule and P-body dynamics. J Cell Sci. 2009;122:3973-82 pubmed publisher that impairment of retrograde transport by knockdown of mammalian dynein heavy chain 1 (DHC1) or bicaudal D1 (BicD1) inhibits SG formation and PB growth upon stress, without affecting protein-synthesis blockage...
  12. KÅ‚oda K, Domanski L, Kwiatkowska E, Borowiecka E, Safranow K, Drozd A, et al. hTERT, BICD1 and chromosome 18 polymorphisms associated with telomere length affect kidney allograft function after transplantation. Kidney Blood Press Res. 2015;40:111-20 pubmed publisher
    ..The aim of this study was to analyse the associations between graft rs2735940 hTERT and rs2630578 BICD1 gene polymorphisms and rs7235755/rs2162440 chromosome 18 polymorphisms, relative TL and kidney function after ..
  13. Matsuto M, Kano F, Murata M. Reconstitution of the targeting of Rab6A to the Golgi apparatus in semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on Golgi membranes and a concerted role of Rab6A/BICD2 interactions in Golgi-to-ER retrograde transport. Biochim Biophys Acta. 2015;1853:2592-609 pubmed publisher
    ..Golgi-targeting assays identified Bicaudal-D (BICD)2, which is reportedly involved in the dynein-mediated transport of mRNAs during oogenesis and embryogenesis in ..
  14. Kłoda K, Mierzecki A, Domanski L, Borowiecka E, Safranow K, Ciechanowicz A, et al. Joint Assessment of Donor and Recipient hTERT Gene Polymorphism Provides Additional Information for Early Kidney Transplantation Outcomes. Med Sci Monit. 2017;23:1812-1818 pubmed
    BACKGROUND There are several genes and genetic loci affecting telomere length, including hTERT gene and BICD1 gene as well as polymorphisms within chromosome 18...
  15. Fuchs E, Short B, Barr F. Assay and properties of rab6 interaction with dynein-dynactin complexes. Methods Enzymol. 2005;403:607-18 pubmed
    ..Standard protocols for yeast two-hybrid analysis, and biochemical assays for the analysis of the interactions between Rab6, Bicaudal-D, and the subunits of the dynein-dynactin complex are outlined. ..
  16. Baens M, Marynen P. A human homologue (BICD1) of the Drosophila bicaudal-D gene. Genomics. 1997;45:601-6 pubmed
    ..A PCR-mediated cDNA cloning strategy was applied to obtain the coding sequence of the human homologue (BICD1) and to generate a partial mouse (Bicdh1) cDNA...
  17. Stuurman N, Haner M, Sasse B, Hubner W, Suter B, Aebi U. Interactions between coiled-coil proteins: Drosophila lamin Dm0 binds to the bicaudal-D protein. Eur J Cell Biol. 1999;78:278-87 pubmed
    ..two-hybrid screen we identified an interaction between Drosophila lamin Dm0, a structural nuclear protein, and BICD, a protein involved in oocyte development...
  18. Storbeck M, Horsberg Eriksen B, Unger A, Holker I, Aukrust I, Martínez Carrera L, et al. Phenotypic extremes of BICD2-opathies: from lethal, congenital muscular atrophy with arthrogryposis to asymptomatic with subclinical features. Eur J Hum Genet. 2017;25:1040-1048 pubmed publisher
    Heterozygous variants in BICD cargo adapter 2 (BICD2) cause autosomal dominant spinal muscular atrophy, lower extremity-predominant 2 (SMALED2)...
  19. Hoogenraad C, Akhmanova A. Bicaudal D Family of Motor Adaptors: Linking Dynein Motility to Cargo Binding. Trends Cell Biol. 2016;26:327-40 pubmed publisher
    ..Characterization of the evolutionary conserved Bicaudal D (BICD) family of dynein adaptor proteins has provided important insights into the fundamental mechanisms governing cargo ..
  20. Fumoto K, Hoogenraad C, Kikuchi A. GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome. EMBO J. 2006;25:5670-82 pubmed
    ..These results imply that GSK-3beta may function in transporting centrosomal proteins to the centrosome by stabilizing the BICD1 and dynein complex, resulting in the regulation of a focused microtubule organization.
  21. Moorhead A, Rzomp K, Scidmore M. The Rab6 effector Bicaudal D1 associates with Chlamydia trachomatis inclusions in a biovar-specific manner. Infect Immun. 2007;75:781-91 pubmed
    ..Using EGFP-tagged fusion proteins, we also demonstrated that the Rab6 effector Bicaudal D1 (BICD1) localized to C. trachomatis inclusions in a biovar-specific manner...
  22. Budzinska M, Wicher K, Terenzio M. Neuronal Roles of the Bicaudal D Family of Motor Adaptors. Vitam Horm. 2017;104:133-152 pubmed publisher
    ..Both mammalian BICD1 and BICD2 are highly expressed in the nervous system during development, and their importance in neuronal ..
  23. Kłoda K, Domanski L, Kwiatkowska E, Safranow K, Drozd A, Ciechanowicz A, et al. BICD1 and Chromosome 18 Polymorphisms Associated With Recipients' Telomere Length Affect Kidney Allograft Function After Transplantation. Transplant Proc. 2016;48:1451-5 pubmed publisher
    ..Therefore the aim of this study was to analyze the associations between recipients' rs2735940 hTERT, rs2630578 BICD1, and rs7235755 chromosome 18 polymorphisms and kidney function after transplantation...
  24. Claussen M, Suter B. BicD-dependent localization processes: from Drosophilia development to human cell biology. Ann Anat. 2005;187:539-53 pubmed
    ..In Drosophila, the microtubule-dependent BicD (BicaudalD) localization machinery is involved in the proper localization of mRNA during oogenesis and ..
  25. Barr F, Short B. Golgins in the structure and dynamics of the Golgi apparatus. Curr Opin Cell Biol. 2003;15:405-13 pubmed
  26. Indran S, Ballestas M, Britt W. Bicaudal D1-dependent trafficking of human cytomegalovirus tegument protein pp150 in virus-infected cells. J Virol. 2010;84:3162-77 pubmed publisher
    ..viral assembly, we utilized yeast two-hybrid analyses to detect an interaction between pp150 and Bicaudal D1 (BicD1), a protein thought to play a role in trafficking within the secretory pathway...
  27. Low S, Kuchiba A, Zembutsu H, Saito A, Takahashi A, Kubo M, et al. Genome-wide association study of pancreatic cancer in Japanese population. PLoS ONE. 2010;5:e11824 pubmed publisher
    ..3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer. ..