Gene Symbol: BHLHE41
Description: basic helix-loop-helix family member e41
Alias: BHLHB3, DEC2, SHARP1, hDEC2, class E basic helix-loop-helix protein 41, basic helix-loop-helix domain containing, class B, 3, differentially expressed in chondrocytes protein 2, enhancer-of-split and hairy-related protein 1
Species: human
Products:     BHLHE41

Top Publications

  1. Miyazaki K, Kawamoto T, Tanimoto K, Nishiyama M, Honda H, Kato Y. Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes. J Biol Chem. 2002;277:47014-21 pubmed
    ..Chem. 276, 15306-15315). In the present study, we found that hypoxia or CoCl(2) enhanced the mRNA expression of DEC2, as well as DEC1, within 24 h in chondrogenic ATDC5, 293T, and HeLa cells...
  2. Montagner M, Enzo E, Forcato M, Zanconato F, Parenti A, Rampazzo E, et al. SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors. Nature. 2012;487:380-4 pubmed publisher
    ..Here we show that SHARP1 (also known as BHLHE41 or DEC2) is a crucial regulator of the invasive and metastatic phenotype in triple-negative breast cancer (TNBC), ..
  3. Wu Y, Sato F, Bhawal U, Kawamoto T, Fujimoto K, Noshiro M, et al. BHLH transcription factor DEC2 regulates pro-apoptotic factor Bim in human oral cancer HSC-3 cells. Biomed Res. 2012;33:75-82 pubmed
    DEC1 (BHLHE40/Stra13/Sharp2) and DEC2 (BHLHE41/Sharp1) are basic helix-loop-helix (bHLH) transcription factors that are involved in the regulation of apoptosis, cell proliferation, circadian rhythms and the response to hypoxia...
  4. Nakashima A, Kawamoto T, Honda K, Ueshima T, Noshiro M, Iwata T, et al. DEC1 modulates the circadian phase of clock gene expression. Mol Cell Biol. 2008;28:4080-92 pubmed publisher
    ..Overexpression of Dec1 delayed the phase of clock genes such as Dec1, Dec2, Per1, and Dbp that contain E boxes in their regulatory regions, whereas it had little effect on the circadian ..
  5. Fujimoto K, Shen M, Noshiro M, Matsubara K, Shingu S, Honda K, et al. Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins. Biochem Biophys Res Commun. 2001;280:164-71 pubmed
    ..We report here the identification and characterization of human, mouse and rat DEC2, a novel member of the DEC subfamily...
  6. Azmi S, Sun H, Ozog A, Taneja R. mSharp-1/DEC2, a basic helix-loop-helix protein functions as a transcriptional repressor of E box activity and Stra13 expression. J Biol Chem. 2003;278:20098-109 pubmed
    ..In this study, we have characterized the DNA-binding and transcriptional properties of the bHLH factor mSharp-1/DEC2. mSharp-1 belongs to the Hairy/Enhancer of Split subfamily of bHLH factors and exhibits the highest structural and ..
  7. Li Y, Shen Q, Kim H, Bissonnette R, Lamph W, Yan B, et al. The rexinoid bexarotene represses cyclin D1 transcription by inducing the DEC2 transcriptional repressor. Breast Cancer Res Treat. 2011;128:667-77 pubmed publisher
    ..Previously we discovered that DEC2 (differentially expressed in chondrocytes-2), a helix-loop-helix transcription repressor, was induced by bexarotene ..
  8. He Y, Jones C, Fujiki N, Xu Y, Guo B, Holder J, et al. The transcriptional repressor DEC2 regulates sleep length in mammals. Science. 2009;325:866-70 pubmed publisher
    ..We have identified a mutation in a transcriptional repressor (hDEC2-P385R) that is associated with a human short sleep phenotype...
  9. Gulbagci N, Li L, Ling B, Gopinadhan S, Walsh M, Rossner M, et al. SHARP1/DEC2 inhibits adipogenic differentiation by regulating the activity of C/EBP. EMBO Rep. 2009;10:79-86 pubmed publisher
    b>SHARP1, a basic helix-loop-helix transcription factor, is expressed in many cell types; however, the mechanisms by which it regulates cellular differentiation remain largely unknown...

More Information


  1. Liao Y, Lu W, Che Q, Yang T, Qiu H, Zhang H, et al. SHARP1 suppresses angiogenesis of endometrial cancer by decreasing hypoxia-inducible factor-1? level. PLoS ONE. 2014;9:e99907 pubmed publisher
    Recent data support a role for SHARP1, a basic helix-loop-helix transcription repressor, in the regulation of malignant cell behavior in several human cancers...
  2. Fujimoto K, Hamaguchi H, Hashiba T, Nakamura T, Kawamoto T, Sato F, et al. Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements. Int J Mol Med. 2007;19:925-32 pubmed
    b>Dec2, a member of the basic helix-loop-helix (bHLH) superfamily, has been shown to function as a transcriptional repressor and is implicated in cell proliferation and differentiation...
  3. Shi J, Wittke Thompson J, Badner J, Hattori E, Potash J, Willour V, et al. Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1047-55 pubmed publisher a family collection of 36 trios and 79 quads (Sample I), and 10 circadian genes (ARNTL, ARNTL2, BHLHB2, BHLHB3, CLOCK, CRY1, CSNK1D, CSNK1E, DBP, and NR1D1) in an extended family collection of 70 trios and 237 quads (Sample ..
  4. Chen M, Guo L, Dong D, Yu F, Zhang T, Wu B. The nuclear receptor Shp regulates morphine withdrawal syndrome via modulation of Ugt2b expression in mice. Biochem Pharmacol. 2019;161:163-172 pubmed publisher
    ..Moreover, Shp positively regulated Ugt2b36 expression through repression of Dec2 and Rev-erbα, two negative regulators of Ugt2b36 enzyme...
  5. Sato F, Otsuka T, Kohsaka A, Le H, Bhawal U, Muragaki Y. Smad3 Suppresses Epithelial Cell Migration and Proliferation Via the Clock Gene Dec1, Which Negatively Regulates the Expression of Clock Genes Dec2 and Per1. Am J Pathol. 2019;: pubmed publisher
    ..Here, we investigated the regulatory mechanisms between Smad3 and the clock genes Dec1, Dec2, and Per1...
  6. McGrath J, Panzica L, Ransom R, Withers H, Gelman I. Identification of Genes Regulating Breast Cancer Dormancy in 3D Bone Endosteal Niche Cultures. Mol Cancer Res. 2019;17:860-869 pubmed publisher
    ..Several potential DRSG were confirmed using independent shRNAs, including BHLHE41, HBP1, and WNT3...
  7. Baier P, Brzózka M, Shahmoradi A, Reinecke L, Kroos C, Wichert S, et al. Mice lacking the circadian modulators SHARP1 and SHARP2 display altered sleep and mixed state endophenotypes of psychiatric disorders. PLoS ONE. 2014;9:e110310 pubmed publisher
    ..The bHLH transcription factors SHARP1/DEC2/BHLHE41 and SHARP2/DEC1/BHLHE40 are modulators of the circadian system and SHARP1/DEC2/BHLHE40 has been shown to regulate ..
  8. Chuang J, Yarmishyn A, Hwang D, Hsu C, Wang M, Yang Y, et al. Expression profiling of cell-intrinsic regulators in the process of differentiation of human iPSCs into retinal lineages. Stem Cell Res Ther. 2018;9:140 pubmed publisher
    ..Along with MITF, the two paralogs, BHLHE41 and BHLHE40, were the most robust TF markers of RPE cells...
  9. Alrbata R, Ha D, Yu W, Kyung H. Optimal asymmetric thread for orthodontic microimplants: Laboratory and clinical evaluation. Angle Orthod. 2015;85:585-90 pubmed publisher
    ..2% vs 75.6%). The better performances of the experimental microimplant, under both laboratory and clinical conditions (although statistically insignificant in the latter), demonstrate the superiority of the new asymmetric thread. ..
  10. Gallo C, Fragliasso V, Donati B, Torricelli F, Tameni A, Piana S, et al. The bHLH transcription factor DEC1 promotes thyroid cancer aggressiveness by the interplay with NOTCH1. Cell Death Dis. 2018;9:871 pubmed publisher
    ..Recently, we found the basic helix-loop-helix transcription factors DEC1 and DEC2 significantly up-regulated in a model of highly aggressive thyroid cancer, raising the hypothesis that these ..
  11. Sun Y, Zhang H, Wang L, Li J, Jin H, Wang Z, et al. Loss of the basic helix-loop-helix transcription factor Bhlhe41 induces cell death and impairs neurite outgrowth in Neuro2a cells. Mol Cell Biochem. 2019;450:167-174 pubmed publisher
    ..In a previous siRNA-based screen, bHLH family member e41 (BHLHE41) had been identified as a putative regulator of neuronal differentiation; however, its function remains largely ..
  12. Seino H, Wu Y, Morohashi S, Kawamoto T, Fujimoto K, Kato Y, et al. Basic helix-loop-helix transcription factor DEC1 regulates the cisplatin-induced apoptotic pathway of human esophageal cancer cells. Biomed Res. 2015;36:89-96 pubmed publisher
    DEC1 [basic helix-loop-helix (BHLH) E40/Stra13/Sharp2] and DEC2 (BHLHE41/Sharp1) are BHLH transcription factors that are associated with the regulation of apoptosis, cell proliferation, and circadian rhythms, as well as malignancy in ..
  13. Numata A, Kwok H, Kawasaki A, Li J, Zhou Q, Kerry J, et al. The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia. Nat Commun. 2018;9:1622 pubmed publisher
    ..Here, we identify the circadian clock transcription factor SHARP1 as a novel oncogenic target in MLL-AF6 AML, which has the worst prognosis among all subtypes of MLL-rearranged ..
  14. Kato Y, Kawamoto T, Fujimoto K, Noshiro M. DEC1/STRA13/SHARP2 and DEC2/SHARP1 coordinate physiological processes, including circadian rhythms in response to environmental stimuli. Curr Top Dev Biol. 2014;110:339-72 pubmed publisher
    ..Clock proteins DEC1 (BHLHe40) and DEC2 (BHLHe41) belong to the basic helix-loop-helix protein superfamily, which contains other clock proteins CLOCK and BMAL1...
  15. Ow J, Tan Y, Jin Y, Bahirvani A, Taneja R. Stra13 and Sharp-1, the non-grouchy regulators of development and disease. Curr Top Dev Biol. 2014;110:317-38 pubmed publisher
    ..Here, we review our current understanding of their cellular functions that suggest a requirement in maintenance of tissue homeostasis. ..
  16. Liang Y, Zhang P, Li S, Li H, Song S, Lu B. MicroRNA-873 acts as a tumor suppressor in esophageal cancer by inhibiting differentiated embryonic chondrocyte expressed gene 2. Biomed Pharmacother. 2018;105:582-589 pubmed publisher
    ..Moreover, we validated differentiated embryonic chondrocyte expressed gene 2 (DEC2) as a direct target of miR-873 which could reverse the repressive effects of miR-873 on esophageal cancer cell...
  17. Zhao Q, Zheng G, Yang K, Ao Y, Su X, Li Y, et al. The clock gene PER1 plays an important role in regulating the clock gene network in human oral squamous cell carcinoma cells. Oncotarget. 2016;7:70290-70302 pubmed publisher
    ..real-time PCR result indicated that in vitro and in vivo cancer cells after PER1 knockdown, PER2, DEC1, DEC2, CRY1, CRY2 and NPAS2 were significantly down-regulated at the mRNA level, while PER3, TIM, RORα and REV-ERBα ..
  18. Kreslavsky T, Wong J, Fischer M, Skok J, Busslinger M. Control of B-1a cell development by instructive BCR signaling. Curr Opin Immunol. 2018;51:24-31 pubmed publisher
    ..advances in our understanding of the development of these cells and their regulation by the transcription factors Bhlhe41 and Arid3a as well as by the RNA-binding protein Lin28b...
  19. Marroncelli N, Bianchi M, Bertin M, Consalvi S, Saccone V, De Bardi M, et al. HDAC4 regulates satellite cell proliferation and differentiation by targeting P21 and Sharp1 genes. Sci Rep. 2018;8:3448 pubmed publisher
    ..By RNA-sequencing analysis we identified P21 and Sharp1 as HDAC4 target genes...
  20. Chen L, Zhou J, Xu H, Xu G, Xue J. Identification and developmental expression of Dec2 in zebrafish. Fish Physiol Biochem. 2010;36:667-675 pubmed publisher
    The involvement of Dec2, a member of the basic helix-loop-helix (bHLH) family, in cellular differentiation, hypoxia response, and circadian regulation has been investigated...
  21. Chen M, Chen Y, Dong S, Lan S, Zhou H, Tan Z, et al. Mixed nitrifying bacteria culture under different temperature dropping strategies: Nitrification performance, activity, and community. Chemosphere. 2018;195:800-809 pubmed publisher
    ..bacteria culture under different temperature dropping strategies [(#1) growth temperature kept at 20?°C; (#2) sharp1 decreased from 20?°C to 10?°C; (#3) growth at 20?°C for 6 days followed by sharp decrease to 10?°C; and (#4) ..
  22. Shahmoradi A, Radyushkin K, Rossner M. Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex. Proc Natl Acad Sci U S A. 2015;112:E3582-9 pubmed publisher
    The bHLH transcription factors SHARP1 and SHARP2 are partially redundant modulators of the circadian system...
  23. Sato F, Kohsaka A, Bhawal U, Muragaki Y. Potential Roles of Dec and Bmal1 Genes in Interconnecting Circadian Clock and Energy Metabolism. Int J Mol Sci. 2018;19: pubmed publisher
    ..Among the clock genes, Dec1 (Bhlhe40/Stra13/Sharp2), Dec2 (Bhlhe41/Sharp1), and Bmal1 (Mop3/Arntl) have been shown to be particularly relevant to ..
  24. Hirano A, Hsu P, Zhang L, Xing L, McMahon T, Yamazaki M, et al. DEC2 modulates orexin expression and regulates sleep. Proc Natl Acad Sci U S A. 2018;115:3434-3439 pubmed publisher
    ..We previously identified a missense mutation in the human DEC2 gene (BHLHE41) leading to the familial natural short sleep behavioral trait...
  25. Blondelle J, Shapiro P, Domenighetti A, Lange S. Cullin E3 Ligase Activity Is Required for Myoblast Differentiation. J Mol Biol. 2017;429:1045-1066 pubmed publisher
    ..We further investigate known transcriptional repressors for terminal muscle differentiation, namely ZBTB38, Bhlhe41, and Id1...
  26. Li P, Jia Y, Ma X, Zheng Y, Kong Y, Zhang Y, et al. DEC2 suppresses tumor proliferation and metastasis by regulating ERK/NF-?B pathway in gastric cancer. Am J Cancer Res. 2016;6:1741-57 pubmed
    Differentiated embryonic chondrocyte expressed gene 2 (DEC2; BHLHE41/Sharp1) is a helix-loop-helix (bHLH) transcription factor, and its deregulation has been observed in several tumors...
  27. Bigot P, Colli L, Machiela M, Jessop L, Myers T, Carrouget J, et al. Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41. Nat Commun. 2016;7:12098 pubmed publisher
    ..of The Cancer Genome Atlas data, SNPs highly correlated with rs7132434 show allele-specific differences in BHLHE41 expression (trend P value=6.3 × 10(-7))...
  28. Zhou J, Yu W, Hardin P. CLOCKWORK ORANGE Enhances PERIOD Mediated Rhythms in Transcriptional Repression by Antagonizing E-box Binding by CLOCK-CYCLE. PLoS Genet. 2016;12:e1006430 pubmed publisher
    ..Given that CWO orthologs DEC1 and DEC2 also target E-boxes bound by CLOCK-BMAL1, a similar mechanism may operate in the mammalian clock.
  29. Dalvie S, King A, Fein G, Ramesar R, Stein D. Possible involvement of the circadian pathway in alcohol use disorder in a South African adolescent cohort. Metab Brain Dis. 2016;31:75-80 pubmed publisher
    ..However, from the gene-based analysis it was found that the circadian rhythm genes NR1D1 and BHLHE41 are associated with AUD...
  30. Kreslavsky T, Vilagos B, Tagoh H, Poliakova D, Schwickert T, Wöhner M, et al. Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells. Nat Immunol. 2017;18:442-455 pubmed publisher
    ..Here we identified an essential role for the transcription factor Bhlhe41, with a lesser contribution by Bhlhe40, in controlling B-1a cell differentiation...
  31. Srdanović S, Þorsteinsson H, Friðriksson Þ, Pétursson S, Maier V, Karlsson K. Transient knock-down of kcna2 reduces sleep in larval zebrafish. Behav Brain Res. 2017;326:13-21 pubmed publisher
    ..The results were compared to a non-overlapping MO injection, Dec2, who's mutant is also linked with a short sleep phenotype...
  32. Jiang B, Mu W, Wang J, Lu J, Jiang S, Li L, et al. MicroRNA-138 functions as a tumor suppressor in osteosarcoma by targeting differentiated embryonic chondrocyte gene 2. J Exp Clin Cancer Res. 2016;35:69 pubmed publisher
    ..of miR-138 on osteosarcoma progression, and to determine whether differentiated embryonic chondrocyte gene 2 (DEC2) mediates these effects...
  33. Oswald F, Winkler M, Cao Y, Astrahantseff K, Bourteele S, Knöchel W, et al. RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Mol Cell Biol. 2005;25:10379-90 pubmed
    ..Furthermore, the endogenous Hey1 promoter is derepressed in CtBP-deficient cells. We propose that a corepressor complex containing CtIP/CtBP facilitates RBP-Jkappa/SHARP-mediated repression of Notch target genes. ..
  34. Imaizumi T, Sato F, Tanaka H, Matsumiya T, Yoshida H, Yashiro Aizawa T, et al. Basic-helix-loop-helix transcription factor DEC2 constitutes negative feedback loop in IFN-?-mediated inflammatory responses in human mesangial cells. Immunol Lett. 2011;136:37-43 pubmed publisher
    Differentiated embryo-chondrocyte 2 (DEC2), a basic-helix-loop-helix transcriptional factor, is involved in various biological reactions by regulating the expression of its target genes...
  35. Li Y, Song X, Ma Y, Liu J, Yang D, Yan B. DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1. Biochem J. 2004;382:895-904 pubmed
    DEC1 (differentially expressed in chondrocytes 1) and DEC2 are E-box-binding transcription factors and exhibit a circadian expression pattern. Recently, both proteins were found to repress the Clock/Bmal1-activated E-box promoters (e.g...
  36. Mansour H, Talkowski M, Wood J, Chowdari K, McClain L, Prasad K, et al. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. Bipolar Disord. 2009;11:701-10 pubmed publisher
    ..5. Additional analyses using adequately powered samples are warranted to further evaluate these results. ..
  37. Sasamoto T, Fujimoto K, Kanawa M, Kimura J, Takeuchi J, Harada N, et al. DEC2 is a negative regulator for the proliferation and differentiation of chondrocyte lineage-committed mesenchymal stem cells. Int J Mol Med. 2016;38:876-84 pubmed publisher
    Differentiated embryo chondrocyte 2 (DEC2) is a basic helix-loop-helix-Orange transcription factor that regulates cell differentiation in various mammalian tissues...
  38. Pellegrino R, Kavakli I, Goel N, Cardinale C, Dinges D, Kuna S, et al. A novel BHLHE41 variant is associated with short sleep and resistance to sleep deprivation in humans. Sleep. 2014;37:1327-36 pubmed publisher
    Earlier work described a mutation in DEC2 also known as BHLHE41 (basic helix-loophelix family member e41) as causal in a family of short sleepers, who needed just 6 h sleep per night...
  39. Falvella F, Spinola M, Manenti G, Conti B, Pastorino U, Skaug V, et al. Common polymorphisms in D12S1034 flanking genes RASSF8 and BHLHB3 are not associated with lung adenocarcinoma risk. Lung Cancer. 2007;56:1-7 pubmed test possible involvement of single-nucleotide polymorphisms (SNPs) in D12S1034 flanking genes RASSF8 and BHLHB3, whose minimal distances from D12S1034 are approximately 16-24 kb...
  40. Zhou Z, Wang B, Cheng X, Zhang X, Tang J, Tang W, et al. Roles of SHARP1 in thyroid cancer. Mol Med Rep. 2016;13:5365-71 pubmed publisher
    b>SHARP1 is a basic helix?loop?helix transcription factor involved in various cellular processes, including proliferation and differentiation. The present study assessed the role of SHARP1 in the progression and invasion of thyroid cancer...
  41. Soria V, Martínez Amorós E, Escaramis G, Valero J, Pérez Egea R, Garcia C, et al. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. Neuropsychopharmacology. 2010;35:1279-89 pubmed publisher
    ..examined 209 single-nucleotide polymorphisms (SNPs) covering 19 circadian genes (ADCYAP1, ARNTL, ARNTL2, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1E, DBP, NPAS2, NR1D1, PER1, PER2, PER3, RORA, TIMELESS, VIP, and VIPR2) in a sample of ..
  42. Kawamoto T, Noshiro M, Sato F, Maemura K, Takeda N, Nagai R, et al. A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem Biophys Res Commun. 2004;313:117-24 pubmed
    ..a basic helix-loop-helix transcription factor: CLOCK/BMAL increased the promoter activity of Dec1, and DEC1 and DEC2 as well as PERs and CRYs suppressed the induced expression...
  43. Coenen E, Zwaan C, Stary J, Baruchel A, de Haas V, Stam R, et al. Unique BHLHB3 overexpression in pediatric acute myeloid leukemia with t(6;11)(q27;q23). Leukemia. 2014;28:1564-8 pubmed publisher
  44. Hu T, He N, Yang Y, Yin C, Sang N, Yang Q. DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas. J Exp Clin Cancer Res. 2015;34:22 pubmed publisher
    ..factor 1) activation is critical for the metabolic reprogramming and progression of solid tumors, and DEC2 (differentiated embryonic chondrocyte gene 2) has been recently reported to suppress HIF-1 in human breast and ..
  45. Matsunaga N, Inoue M, Kusunose N, Kakimoto K, Hamamura K, Hanada Y, et al. Time-dependent interaction between differentiated embryo chondrocyte-2 and CCAAT/enhancer-binding protein ? underlies the circadian expression of CYP2D6 in serum-shocked HepG2 cells. Mol Pharmacol. 2012;81:739-47 pubmed publisher
    Differentiated embryo chondrocyte-2 (DEC2), also known as bHLHE41 or Sharp1, is a pleiotropic transcription repressor that controls the expression of genes involved in cellular differentiation, hypoxia responses, apoptosis, and circadian ..
  46. Sato F, Kawamoto T, Fujimoto K, Noshiro M, Honda K, Honma S, et al. Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. Eur J Biochem. 2004;271:4409-19 pubmed
    ..Moreover, mutant DEC1 also counteracted DEC2-mediated suppressive activity in a dominant-negative manner...
  47. Inaguma S, Riku M, Hashimoto M, Murakami H, Saga S, Ikeda H, et al. GLI1 interferes with the DNA mismatch repair system in pancreatic cancer through BHLHE41-mediated suppression of MLH1. Cancer Res. 2013;73:7313-23 pubmed publisher
    ..gene screening, we found that GLI1 and GLI2 activated the expression of a basic helix-loop-helix type suppressor BHLHE41/DEC2/SHARP1 through a GLI-binding site in the promoter...
  48. Olkkonen J, Kouri V, Hynninen J, Konttinen Y, Mandelin J. Differentially Expressed in Chondrocytes 2 (DEC2) Increases the Expression of IL-1β and Is Abundantly Present in Synovial Membrane in Rheumatoid Arthritis. PLoS ONE. 2015;10:e0145279 pubmed publisher
    ..Our objective was to investigate the expression of direct clock suppressors DEC1 and DEC2 (BHLHE 40 and 41 proteins) in response to TNFα and investigate their role during inflammation...
  49. Li Y, Xie M, Song X, Gragen S, Sachdeva K, Wan Y, et al. DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter. J Biol Chem. 2003;278:16899-907 pubmed
    ..The present study was undertaken to extend the expression study of DEC1 and to determine whether DEC1 and DEC2 had similar expression patterns among paired cancer-normal tissues from the colon, lung, and kidney...
  50. Wang Y, Shankar S, Kher D, Ling B, Taneja R. Sumoylation of the basic helix-loop-helix transcription factor sharp-1 regulates recruitment of the histone methyltransferase G9a and function in myogenesis. J Biol Chem. 2013;288:17654-62 pubmed publisher
    ..Our findings demonstrate how sumoylation of Sharp-1 exerts an impact on chromatin structure and transcriptional repression of muscle gene expression through recruitment of G9a. ..
  51. Garriga Canut M, Roopra A, Buckley N. The basic helix-loop-helix protein, sharp-1, represses transcription by a histone deacetylase-dependent and histone deacetylase-independent mechanism. J Biol Chem. 2001;276:14821-8 pubmed
    ..Furthermore, overexpression of SHARP-1 represses transcription from the M(1) promoter. This study represents the first report to assign a function to, and to identify a target gene for, the bHLH transcription factor SHARP-1. ..
  52. Utge S, Soronen P, Loukola A, Kronholm E, Ollila H, Pirkola S, et al. Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance. PLoS ONE. 2010;5:e9259 pubmed publisher
    ..These findings support a connection between circadian genes and gender-dependent depression and defective sleep regulation. ..
  53. Cho Y, Noshiro M, Choi M, Morita K, Kawamoto T, Fujimoto K, et al. The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors. Mol Pharmacol. 2009;76:1360-9 pubmed publisher
    The basic helix-loop-helix proteins differentiated embryo chondrocyte 1 (DEC1) and DEC2 are involved in circadian rhythm control...
  54. Grampp S, Schmid V, Salama R, Lauer V, Kranz F, Platt J, et al. Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway. PLoS Genet. 2017;13:e1006872 pubmed publisher
    ..directly creates a new HIF-binding site that mediates HIF-1α isoform specific upregulation of its target BHLHE41. The alignment of multiple sites in the HIF cis-acting apparatus with RCC-susceptibility polymorphisms strongly ..
  55. Nakamura H, Tanimoto K, Hiyama K, Yunokawa M, Kawamoto T, Kato Y, et al. Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2. Oncogene. 2008;27:4200-9 pubmed publisher
    ..Co-transfection reporter assay revealed that DEC1 and, to greater extent, DEC2 as well as hypoxia-repressed MLH1 promoter activity...
  56. Liu Q, Wu Y, Yoshizawa T, Yan X, Morohashi S, Seino H, et al. Basic helix-loop-helix transcription factor DEC2 functions as an anti-apoptotic factor during paclitaxel-induced apoptosis in human prostate cancer cells. Int J Mol Med. 2016;38:1727-1733 pubmed publisher
    ..basic helix-loop-helix (bHLH) transcription factor-differentiated embryonic chondrocyte (DEC)1 (BHLHE40) and 2 (BHLHE41) are involved in various fields such as circadian rhythms, immune responses, cell proliferation, hypoxia reaction ..
  57. Asanoma K, Liu G, Yamane T, Miyanari Y, Takao T, Yagi H, et al. Regulation of the Mechanism of TWIST1 Transcription by BHLHE40 and BHLHE41 in Cancer Cells. Mol Cell Biol. 2015;35:4096-109 pubmed publisher
    BHLHE40 and BHLHE41 (BHLHE40/41) are basic helix-loop-helix type transcription factors that play key roles in multiple cell behaviors. BHLHE40/41 were recently shown to be involved in an epithelial-to-mesenchymal transition (EMT)...
  58. Liao Y, He X, Qiu H, Che Q, Wang F, Lu W, et al. Suppression of the epithelial-mesenchymal transition by SHARP1 is linked to the NOTCH1 signaling pathway in metastasis of endometrial cancer. BMC Cancer. 2014;14:487 pubmed publisher
    ..Recent data support a role for Enhancer-of-split and hairy-related protein 1 (SHARP1), a basic helix-loop-helix transcription repressor, in regulating invasiveness and angiogenesis of several human ..
  59. Wu Y, Sato F, Bhawal U, Kawamoto T, Fujimoto K, Noshiro M, et al. Basic helix-loop-helix transcription factors DEC1 and DEC2 regulate the paclitaxel-induced apoptotic pathway of MCF-7 human breast cancer cells. Int J Mol Med. 2011;27:491-5 pubmed publisher
    Differentiated embryonic chondrocyte gene (DEC) 1 (BHLHE40/Stra13/Sharp2) and DEC2 (BHLHE41/Sharp1) are basic helix-loop-helix (bHLH) transcription factors that are associated with the regulation of apoptosis, cell proliferation and ..
  60. Falvella F, Colombo F, Spinola M, Campiglio M, Pastorino U, Dragani T. BHLHB3: a candidate tumor suppressor in lung cancer. Oncogene. 2008;27:3761-4 pubmed publisher
    b>BHLHB3 is a basic helix-loop-helix (bHLH) domain-containing protein that acts as a transcriptional repressor...
  61. Wu Y, Sato H, Suzuki T, Yoshizawa T, Morohashi S, Seino H, et al. Involvement of c-Myc in the proliferation of MCF-7 human breast cancer cells induced by bHLH transcription factor DEC2. Int J Mol Med. 2015;35:815-20 pubmed publisher
    ..expressed gene 1 (DEC1; BHLHE40/Stra13/Sharp2) and differentiated embryonic chondrocyte expressed gene 2 (DEC2; BHLHE41/Sharp1) are basic helix-loop-helix (bHLH) transcriptional factors that are involved in the regulation of cell ..
  62. Suzuki M, Sato F, Bhawal U. The basic helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates Twist1 through an E-box element. Biochem Biophys Res Commun. 2014;455:390-5 pubmed publisher
    Differentiated embryo chondrocyte 2 (DEC2/Sharp-1/Bhlhe41), a basic helix-loop-helix (bHLH) transcription factor, has been shown to regulate the transcription of target genes by binding to their E-box elements...
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