BHLHE40

Summary

Gene Symbol: BHLHE40
Description: basic helix-loop-helix family member e40
Alias: BHLHB2, Clast5, DEC1, HLHB2, SHARP-2, SHARP2, STRA13, Stra14, class E basic helix-loop-helix protein 40, basic helix-loop-helix domain containing, class B, 2, class B basic helix-loop-helix protein 2, differentially expressed in chondrocytes 1, differentially expressed in chondrocytes protein 1, differentiated embryo chondrocyte expressed gene 1, enhancer-of-split and hairy-related protein 2, stimulated by retinoic acid gene 13 protein
Species: human
Products:     BHLHE40

Top Publications

  1. Ivanova A, Ivanov S, Danilkovitch Miagkova A, Lerman M. Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway. J Biol Chem. 2001;276:15306-15 pubmed
    In this study, we focus on different modes of regulation of STRA13, a human ortholog of the mouse basic helix-loop-helix transcriptional factor, previously identified by us as a new von Hippel-Lindau tumor suppressor gene (VHL) target...
  2. Hong Y, Xing X, Li S, Bi H, Yang C, Zhao F, et al. SUMOylation of DEC1 protein regulates its transcriptional activity and enhances its stability. PLoS ONE. 2011;6:e23046 pubmed publisher
    Differentiated embryo-chondrocyte expressed gene 1 (DEC1, also known as sharp2, stra13, or BHLHB2) is a mammalian basic helix-loop-helix protein that is involved in many aspects of gene regulation through acting as a transcription factor...
  3. Sato F, Kawamoto T, Fujimoto K, Noshiro M, Honda K, Honma S, et al. Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. Eur J Biochem. 2004;271:4409-19 pubmed
    The basic helix-loop-helix transcription factor DEC1 is expressed in a circadian manner in the suprachiasmatic nucleus where it seems to play a role in regulating the mammalian circadian rhythm by suppressing the CLOCK/BMAL1-activated ..
  4. Wang W, Reiser Erkan C, Michalski C, Raggi M, Quan L, Yupei Z, et al. Hypoxia inducible BHLHB2 is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma. Biochem Biophys Res Commun. 2010;401:422-8 pubmed publisher
    ..adenosine monophosphate-inducible basic helix-loop-helix (bHLH) domain containing class-B2 transcriptional factor BHLHB2 is differentially expressed in a number of human malignancies...
  5. Li Y, Zhang H, Xie M, Hu M, Ge S, Yang D, et al. Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation. Biochem J. 2002;367:413-22 pubmed
    ..The present study describes the functional characterization of DEC1. Subtractive experiments and blotting analyses demonstrated that DEC1 was highly expressed in colon carcinomas, but ..
  6. Cho Y, Noshiro M, Choi M, Morita K, Kawamoto T, Fujimoto K, et al. The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors. Mol Pharmacol. 2009;76:1360-9 pubmed publisher
    The basic helix-loop-helix proteins differentiated embryo chondrocyte 1 (DEC1) and DEC2 are involved in circadian rhythm control...
  7. Giatromanolaki A, Koukourakis M, Sivridis E, Turley H, Wykoff C, Gatter K, et al. DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer. J Pathol. 2003;200:222-8 pubmed
    Differentiated embryo-chondrocyte expressed gene 1 (DEC1) is involved in cell differentiation, proliferation, and apoptosis, and was recently shown to be regulated by hypoxia...
  8. Nakashima A, Kawamoto T, Honda K, Ueshima T, Noshiro M, Iwata T, et al. DEC1 modulates the circadian phase of clock gene expression. Mol Cell Biol. 2008;28:4080-92 pubmed publisher
    b>DEC1 suppresses CLOCK/BMAL1-enhanced promoter activity, but its role in the circadian system of mammals remains unclear...
  9. Thin T, Li L, Chung T, Sun H, Taneja R. Stra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosis. EMBO Rep. 2007;8:401-7 pubmed
    ..In this study, we have identified stimulated with retinoic acid 13 (Stra13), a basic helix-loop-helix transcription factor, as a regulator of ionizing-radiation-induced apoptosis...

More Information

Publications81

  1. Fujimoto K, Hamaguchi H, Hashiba T, Nakamura T, Kawamoto T, Sato F, et al. Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements. Int J Mol Med. 2007;19:925-32 pubmed
    ..Gel retardation and luciferase assays showed that Dec2, as well as its related protein Dec1, preferentially binds to class B E-box elements (CACGTG) as a homodimer and represses the transcription of target ..
  2. Kawamoto T, Noshiro M, Sato F, Maemura K, Takeda N, Nagai R, et al. A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem Biophys Res Commun. 2004;313:117-24 pubmed
    ..We show here an autofeedback loop of Dec1 encoding a basic helix-loop-helix transcription factor: CLOCK/BMAL increased the promoter activity of Dec1, and ..
  3. Li Y, Xie M, Song X, Gragen S, Sachdeva K, Wan Y, et al. DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter. J Biol Chem. 2003;278:16899-907 pubmed
    ..Recently, we have reported that DEC1 is abundantly expressed in colon carcinomas but not in the adjacent normal tissues...
  4. Miyazaki K, Kawamoto T, Tanimoto K, Nishiyama M, Honda H, Kato Y. Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes. J Biol Chem. 2002;277:47014-21 pubmed
    ..e. in chondrocytes) and pathologically (i.e. in tumor cells). Previous studies have shown that DEC1, a basic helix-loop-helix transcription factor, is induced by hypoxia in glioma cells (Ivanova, A. V., Ivanov, S. V...
  5. Liu Y, Miao Y, Wang J, Lin X, Wang L, Xu H, et al. DEC1 is positively associated with the malignant phenotype of invasive breast cancers and negatively correlated with the expression of claudin-1. Int J Mol Med. 2013;31:855-60 pubmed publisher
    Differentiated embryo-chondrocyte expressed gene 1 (DEC1) is a basic helix-loop-helix transcriptional regulator, reportedly involved in cell growth, differentiation, apoptosis and tumorigenesis...
  6. Zheng Y, Jia Y, Wang Y, Wang M, Li B, Shi X, et al. The hypoxia-regulated transcription factor DEC1 (Stra13, SHARP-2) and its expression in gastric cancer. OMICS. 2009;13:301-6 pubmed publisher
    Differentiated embryo-chondrocyte expressed gene 1 (DEC1), as a bHLH transcriptional factor, plays important roles in cell differentiation, proliferation, and apoptosis...
  7. Nakamura H, Tanimoto K, Hiyama K, Yunokawa M, Kawamoto T, Kato Y, et al. Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2. Oncogene. 2008;27:4200-9 pubmed publisher
    ..gene, MLH1, and demonstrated that hypoxia-inducible transcription repressors, differentiated embryo chondrocytes (DEC1 and 2), participated in its transcriptional regulation via their bindings to E-box-like motif(s) in MLH1 promoter ..
  8. Qian Y, Zhang J, Yan B, Chen X. DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. J Biol Chem. 2008;283:2896-905 pubmed
    ..Among the many candidates is DEC1, a basic helix-loop-helix transcription factor that has been recently shown to be up-regulated in K-ras-induced ..
  9. Qian Y, Jung Y, Chen X. Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1. Proc Natl Acad Sci U S A. 2012;109:11300-5 pubmed publisher
    ..Previously, we showed that DEC1, a basic helix-loop-helix transcription factor and a target of p53, is capable of inducing cell cycle arrest and ..
  10. Zhang L, Li Q. Embryo-chondrocyte expressed gene 1, downregulating hypoxia-inducible factor 1alpha, is another marker of lung tumor hypoxia. Acta Pharmacol Sin. 2007;28:549-58 pubmed
    To explore the mechanism of differentiated embryo-chondrocyte expressed gene 1 (DEC1) in the lung adenocarcinoma A549 cell line and its relationship with hypoxia-inducible factor 1alpha(HIF-1alpha)...
  11. Sun H, Taneja R. Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms. Proc Natl Acad Sci U S A. 2000;97:4058-63 pubmed
    b>Stra13 is a transcriptional repressor related within its basic helix-loop-helix domain with the Drosophila Hairy, Enhancer of Split, and the mouse Hes1 proteins that interact with the corepressor Groucho...
  12. Yoon D, Buchler P, Saarikoski S, Hines O, Reber H, Hankinson O. Identification of genes differentially induced by hypoxia in pancreatic cancer cells. Biochem Biophys Res Commun. 2001;288:882-6 pubmed
    ..In addition, hexokinase II and DEC1/Stra13, genes known to be hypoxia inducible in other systems, were found to be hypoxia inducible in our pancreatic cancer ..
  13. Shen M, Yoshida E, Yan W, Kawamoto T, Suardita K, Koyano Y, et al. Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages. J Biol Chem. 2002;277:50112-20 pubmed
    The mRNA level of basic helix-loop-helix transcription factor DEC1 (BHLHB2)/Stra13/Sharp2 was up-regulated during chondrocyte differentiation in cultures of ATDC5 cells and growth plate chondrocytes, and in growth plate cartilage in vivo...
  14. Li Y, Song X, Ma Y, Liu J, Yang D, Yan B. DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1. Biochem J. 2004;382:895-904 pubmed
    DEC1 (differentially expressed in chondrocytes 1) and DEC2 are E-box-binding transcription factors and exhibit a circadian expression pattern. Recently, both proteins were found to repress the Clock/Bmal1-activated E-box promoters (e.g...
  15. Honma S, Kawamoto T, Takagi Y, Fujimoto K, Sato F, Noshiro M, et al. Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature. 2002;419:841-4 pubmed
    ..We found that Dec1 and Dec2, basic helix-loop-helix transcription factors, repressed Clock/Bmal1-induced transactivation of the mouse ..
  16. Ivanov S, Salnikow K, Ivanova A, Bai L, Lerman M. Hypoxic repression of STAT1 and its downstream genes by a pVHL/HIF-1 target DEC1/STRA13. Oncogene. 2007;26:802-12 pubmed
    DEC1/STRA13 is a bHLH type transcriptional regulator involved with immune regulation, hypoxia response and carcinogenesis...
  17. Qian Y, Jung Y, Chen X. DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. J Biol Chem. 2011;286:12033-41 pubmed publisher
    ..Here, we showed that ?Np63 is regulated by the transcription factor DEC1, a p53 family target...
  18. Wu Y, Sato F, Yamada T, Bhawal U, Kawamoto T, Fujimoto K, et al. The BHLH transcription factor DEC1 plays an important role in the epithelial-mesenchymal transition of pancreatic cancer. Int J Oncol. 2012;41:1337-46 pubmed publisher
    DEC1 (BHLHE40/Stra13/Sharp2) is a basic helix-loop-helix (bHLH) transcription factor that is involved in the regulation of apoptosis and cell proliferation and the response to hypoxia...
  19. St Pierre B, Flock G, Zacksenhaus E, Egan S. Stra13 homodimers repress transcription through class B E-box elements. J Biol Chem. 2002;277:46544-51 pubmed
    A mammalian basic helix-loop-helix protein known variably as Stra13, Sharp2, and Dec1 has been implicated in cell activation, proliferation, and differentiation...
  20. Shen M, Kawamoto T, Yan W, Nakamasu K, Tamagami M, Koyano Y, et al. Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes. Biochem Biophys Res Commun. 1997;236:294-8 pubmed
    ..Using this culture system, a novel human cDNA for a basic helix-loop-helix (bHLH) protein (named DEC1) expressed primarily in the chondrocytes in response to Bt2cAMP was cloned by the subtractive hybridization method...
  21. Li Y, Xie M, Yang J, Yang D, Deng R, Wan Y, et al. The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter. Oncogene. 2006;25:3296-306 pubmed
    ..b>DEC1 is abundantly expressed in tumors and protects against apoptosis induced by serum starvation...
  22. Shi J, Wittke Thompson J, Badner J, Hattori E, Potash J, Willour V, et al. Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1047-55 pubmed publisher
    ..and TIMELESS) in a family collection of 36 trios and 79 quads (Sample I), and 10 circadian genes (ARNTL, ARNTL2, BHLHB2, BHLHB3, CLOCK, CRY1, CSNK1D, CSNK1E, DBP, and NR1D1) in an extended family collection of 70 trios and 237 quads (..
  23. Ivanova A, Ivanov S, Zhang X, Ivanov V, Timofeeva O, Lerman M. STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets. J Mol Biol. 2004;340:641-53 pubmed
    b>STRA13 is a pVHL-dependent bHLH transcription factor up-regulated on the mRNA level in multiple cancer cell lines and implicated recently in the regulation of immune cell homeostasis and autoimmunity...
  24. Ivanova A, Liao S, Lerman M, Ivanov S, Stanbridge E. STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker. J Med Genet. 2005;42:565-76 pubmed
    b>STRA13 is a bHLH transcription factor that plays a crucial role in cell differentiation, proliferation, apoptosis, and response to hypoxia. To assess STRA13 involvement in carcinogenesis and evaluate its diagnostic value...
  25. Teramoto M, Nakamasu K, Noshiro M, Matsuda Y, Gotoh O, Shen M, et al. Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2. J Biochem. 2001;129:391-6 pubmed
    DEC1/BHLHB2 is a novel cAMP-inducible basic helix-loop-helix (bHLH) transcriptional factor isolated from human chondrocyte cultures by the subtraction method [Shen et al. (1997) Biochem. Biophys. Res. Commun. 236, 294--298]...
  26. Zheng Y, Shi X, Wang M, Jia Y, Li B, Zhang Y, et al. The increased expression of DEC1 gene is related to HIF-1? protein in gastric cancer cell lines. Mol Biol Rep. 2012;39:4229-36 pubmed publisher
    Overexpression of differentiated embryo chondrocyte 1 (DEC1) has been reported to contribute to the cellular differentiation, proliferation, and apoptosis of various cancers...
  27. Shi X, Zheng Y, Sun Q, Cui J, Liu Q, Qu F, et al. DEC1 nuclear expression: a marker of differentiation grade in hepatocellular carcinoma. World J Gastroenterol. 2011;17:2037-43 pubmed publisher
    To investigate the expression patterns of human differentiated embryo chondrocyte 1 (DEC1) in hepatocellular carcinoma (HCC) and corresponding adjacent non-tumor and the normal liver tissues, the association between DEC1 expression and ..
  28. Talasila K, Røsland G, Hagland H, Eskilsson E, Flønes I, Fritah S, et al. The angiogenic switch leads to a metabolic shift in human glioblastoma. Neuro Oncol. 2017;19:383-393 pubmed publisher
    ..linked to a proneural-to-mesenchymal transition that is associated with upregulation of the transcription factors BHLHE40, CEBPB, and STAT3...
  29. Li Y, Liu B, Harmacek L, Long Z, Liang J, Lukin K, et al. The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis. J Allergy Clin Immunol. 2018;142:1173-1184 pubmed publisher
    ..receptor (Ahr), aryl hydrocarbon receptor repressor (Ahrr), or basic helix-loop-helix family member E40 (Bhlhe40) were assessed for anaphylactic reactions...
  30. Jinhua H, Zhao M, Wei S, Haitao Y, Yuwen W, Lili W, et al. Down regulation of differentiated embryo-chondrocyte expressed gene 1 is related to the decrease of osteogenic capacity. Curr Drug Targets. 2014;15:432-41 pubmed
    Differentiated embryo-chondrocyte expressed gene 1 (DEC1) is associated with chondrogenesis, neurogenesis, immune response, biological rhythm, lipogenesis, cell differentiation and carcinogenesis...
  31. Schulten H, Hussein D, Al Adwani F, Karim S, Al Maghrabi J, Al Sharif M, et al. Microarray Expression Data Identify DCC as a Candidate Gene for Early Meningioma Progression. PLoS ONE. 2016;11:e0153681 pubmed publisher
    ..63 (C5orf63), homeodomain interacting protein kinase 2 (HIPK2), and basic helix-loop-helix family, member e40 (BHLHE40)...
  32. Mogi A, Yomoda R, Kimura S, Tsushima C, Takouda J, Sawauchi M, et al. Entrainment of the Circadian Clock in Neural Stem Cells by Epidermal Growth Factor is Closely Associated with ERK1/2-mediated Induction of Multiple Clock-related Genes. Neuroscience. 2018;379:45-66 pubmed publisher
    ..validation demonstrated that EGF treatment transiently induced multiple clock-related genes including Per1, Per2, Dec1, e4bp4, and Noct, whereas FK treatment induced a limited number of genes (Per1 and Dec1), suggesting that the mode ..
  33. Sato M, Wakamura T, Morita T, Okamoto A, Akashi M, Matsui T, et al. Effects of bright light exposure during daytime on peripheral clock gene expression in humans. Int J Biometeorol. 2017;61:1133-1138 pubmed publisher
    ..The mRNA expression of Per1-3, Cry1-2, Rev-erb-α (Nr1d1), Rev-erb-β (Nr1d2), and Dec1 was analyzed using branched DNA probes...
  34. Li X, Lin W, Wang J, Zhang W, Yin A, Huang Y, et al. Dec1 expression predicts prognosis and the response to temozolomide chemotherapy in patients with glioma. Mol Med Rep. 2016;14:5626-5636 pubmed publisher
    Differentiated embryo chondrocyte expressed gene 1 (Dec1), a crucial cell differentiation mediator and apoptosis inhibitor, is abundantly expressed in various types of human cancer and is associated with malignant tumor progression...
  35. Utge S, Soronen P, Loukola A, Kronholm E, Ollila H, Pirkola S, et al. Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance. PLoS ONE. 2010;5:e9259 pubmed publisher
    ..These findings support a connection between circadian genes and gender-dependent depression and defective sleep regulation. ..
  36. Andersen M, Black M, Campbell J, Pendse S, Clewell H, Pottenger L, et al. Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver. Toxicol Appl Pharmacol. 2017;332:149-158 pubmed publisher
    ..concentration-related response at higher concentrations (Arntl, Npas2, and Clock were down-regulated; Cry2, Wee1, Bhlhe40, Per3, Nr1d1, Nr1d2 and Dbp) were up-regulated with similar directionality in both tissues...
  37. Kreslavsky T, Vilagos B, Tagoh H, Poliakova D, Schwickert T, Wöhner M, et al. Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells. Nat Immunol. 2017;18:442-455 pubmed publisher
    ..Here we identified an essential role for the transcription factor Bhlhe41, with a lesser contribution by Bhlhe40, in controlling B-1a cell differentiation...
  38. Visentini M, Cagliuso M, Conti V, Carbonari M, Cibati M, Siciliano G, et al. Clonal B cells of HCV-associated mixed cryoglobulinemia patients contain exhausted marginal zone-like and CD21 low cells overexpressing Stra13. Eur J Immunol. 2012;42:1468-76 pubmed publisher
    ..These cells also express abundant transcripts of Stra13 (DEC1, Bhlhb2, Sharp2, Clast5), a basic helix-loop-helix transcription factor that acts as a powerful negative regulator of B-cell proliferation ..
  39. Liu Y, Wang L, Lin X, Wang J, Yu J, Miao Y, et al. The transcription factor DEC1 (BHLHE40/STRA13/SHARP-2) is negatively associated with TNM stage in non-small-cell lung cancer and inhibits the proliferation through cyclin D1 in A549 and BE1 cells. Tumour Biol. 2013;34:1641-50 pubmed publisher
    ..the expression pattern and clinicopathological significance of differentiated embryo-chondrocyte-expressed gene 1 (DEC1) in patients with non-small-cell lung cancer (NSCLC)...
  40. Long Y, Tsai W, Chang J, Estecio M, Wangpaichitr M, Savaraj N, et al. Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation. Oncotarget. 2016;7:82658-82670 pubmed publisher
    ..We further demonstrated that the clock protein DEC1 is the master regulator of HIF-1α and c-Myc that regulate ASS1...
  41. Komatsu Y, Yanagisawa Y, Moriizumi M, Tsuchiya Y, Yokouchi H, Otsuka H, et al. 5-Aminoimidazole-4-carboxyamide-1-β-D-ribofranoside stimulates the rat enhancer of split- and hairy-related protein-2 gene via atypical protein kinase C lambda. J Biochem. 2016;159:429-36 pubmed publisher
    ..Thus, we conclude that the AICAR-induction of theSHARP-2gene is mediated at transcription level by a PI 3-K/aPKCλ pathway. ..
  42. Bi H, Li S, Qu X, Wang M, Bai X, Xu Z, et al. DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase. Cell Death Dis. 2015;6:e1891 pubmed publisher
    ..The transcription factor DEC1 (also known as STRA13 and SHARP2) plays an important role in cell proliferation and apoptosis...
  43. Sato F, Muragaki Y, Zhang Y. DEC1 negatively regulates AMPK activity via LKB1. Biochem Biophys Res Commun. 2015;467:711-6 pubmed publisher
    Basic helix-loop-helix (bHLH) transcription factor DEC1 (bHLHE40/Stra13/Sharp2) is one of the clock genes that show a circadian rhythm in various tissues...
  44. Hu J, Mao Z, He S, Zhan Y, Ning R, Liu W, et al. Icariin protects against glucocorticoid induced osteoporosis, increases the expression of the bone enhancer DEC1 and modulates the PI3K/Akt/GSK3?/?-catenin integrated signaling pathway. Biochem Pharmacol. 2017;136:109-121 pubmed publisher
    ..We have also shown that dexamethasone (a glucocorticoid) suppressed and icariin induced DEC1, a structurally distinct helix-loop-helix protein...
  45. Olkkonen J, Kouri V, Hynninen J, Konttinen Y, Mandelin J. Differentially Expressed in Chondrocytes 2 (DEC2) Increases the Expression of IL-1β and Is Abundantly Present in Synovial Membrane in Rheumatoid Arthritis. PLoS ONE. 2015;10:e0145279 pubmed publisher
    ..Our objective was to investigate the expression of direct clock suppressors DEC1 and DEC2 (BHLHE 40 and 41 proteins) in response to TNFα and investigate their role during inflammation...
  46. Cardoso T, Quintanilla R, Tibau J, Gil M, Mármol Sánchez E, González Rodríguez O, et al. Nutrient supply affects the mRNA expression profile of the porcine skeletal muscle. BMC Genomics. 2017;18:603 pubmed publisher
    ..we have identified several loci playing a key role in the modulation of circadian rhythms (ARNTL, PER1, PER2, BHLHE40, NR1D1, SIK1, CIART and CRY2), a result that indicates that the porcine muscle circadian clock is modulated by ..
  47. Seino H, Wu Y, Morohashi S, Kawamoto T, Fujimoto K, Kato Y, et al. Basic helix-loop-helix transcription factor DEC1 regulates the cisplatin-induced apoptotic pathway of human esophageal cancer cells. Biomed Res. 2015;36:89-96 pubmed publisher
    DEC1 [basic helix-loop-helix (BHLH) E40/Stra13/Sharp2] and DEC2 (BHLHE41/Sharp1) are BHLH transcription factors that are associated with the regulation of apoptosis, cell proliferation, and circadian rhythms, as well as malignancy in ..
  48. Ivanova A, Ivanov S, Lerman M. Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins. Cell Mol Life Sci. 2005;62:471-84 pubmed
    b>STRA13 is a hypoxia-inducible bHLH transcription factor implicated in the pVHL/HIF, TGF-beta, and Jak/STAT pathways...
  49. Xu X, Guo Y, Zhao J, He S, Wang Y, Lin Y, et al. Punicalagin, a PTP1B inhibitor, induces M2c phenotype polarization via up-regulation of HO-1 in murine macrophages. Free Radic Biol Med. 2017;110:408-420 pubmed publisher
    ..down-regulated, while M2 marker genes, including Tmem171, Gpr35, Csf1, Il1rn, Cebpb, Fos, Vegf?, Slc11a1, and Bhlhe40 were up-regulated in PUN-treated macrophages...
  50. Ding Y, Shao X, Li X, Zhai Y, Zhang Y, Wang S, et al. Identification of candidate genes in atopic dermatitis based on bioinformatic methods. Int J Dermatol. 2016;55:791-800 pubmed publisher
    ..Stimulated by retinoic acid 13 (STRA13), presenilin enhancer gamma secretase subunit (PSENEN), and nucleosome assembly protein 1-like 2 (NAP1L2) were ..
  51. Rome S, Meugnier E, Lecomte V, Berbe V, Besson J, Cerutti C, et al. Microarray analysis of genes with impaired insulin regulation in the skeletal muscle of type 2 diabetic patients indicates the involvement of basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2). Diabetologia. 2009;52:1899-912 pubmed publisher
    ..contribution of the transcriptional repressor basic helix-loop-helix domain-containing, class B, 2 protein (BHLHB2), insulin regulation of which is strongly altered in the muscle of diabetic patients...
  52. Chu Y, Liu S, Yang Y, Huang S, Wang W. The cytotoxic mechanism of epigallocatechin gallate on proliferative HaCaT keratinocytes. J Biomed Sci. 2017;24:55 pubmed publisher
    ..It also induced the expression of p21 and DEC1 (differentiated embryo-chondrocyte expressed gene 1), and promoted G1 arrest of cell cycle in proliferative ..
  53. Zhao M, Xiaofei L, Gang C, Wei L, Jing X, Gang H, et al. DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes. Biochem Pharmacol. 2012;84:701-711 pubmed publisher
    ..After human hepatocytes were treated with IL-6, differentially expressed in chondrocytes 1 (DEC1) expression rapidly increased, and subsequently, the CYP3A4 expression decreased ..
  54. Sato F, Kohsaka A, Takahashi K, Otao S, Kitada Y, Iwasaki Y, et al. Smad3 and Bmal1 regulate p21 and S100A4 expression in myocardial stromal fibroblasts via TNF-?. Histochem Cell Biol. 2017;148:617-624 pubmed publisher
    ..We also examined Smad3, Bmal1 and Dec1 expression in human tissue from old myocardial infarctions...
  55. Sun H, Lu B, Li R, Flavell R, Taneja R. Defective T cell activation and autoimmune disorder in Stra13-deficient mice. Nat Immunol. 2001;2:1040-7 pubmed
    b>Stra13, a basic helix-loop-helix transcription factor, is up-regulated upon activation of CD4+ T cells. Here we show that Stra13-deficient mice exhibit defects in several phases of CD4+ T cell activation...
  56. Andersen M, Cruzan G, Black M, Pendse S, Dodd D, Bus J, et al. Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling following 1-day and multi-week exposures. Toxicol Appl Pharmacol. 2017;335:28-40 pubmed publisher
    ..At 4 and 26weeks, some key transcription factors (TFs) - Nr1d1, Nr1d2, Dbp, Tef, Hlf, Per3, Per2 and Bhlhe40 - were upregulated (|FC|>1...
  57. Ning R, Zhan Y, He S, Hu J, Zhu Z, Hu G, et al. Interleukin-6 Induces DEC1, Promotes DEC1 Interaction with RXR? and Suppresses the Expression of PXR, CAR and Their Target Genes. Front Pharmacol. 2017;8:866 pubmed publisher
    ..b>DEC1 (differentiated embryonic chondrocyte-expressed gene 1) is a ligand-independent transcription factor and reportedly ..
  58. Preusser M, Birner P, Ambros I, Ambros P, Budka H, Harris A, et al. DEC1 expression in 1p-aberrant oligodendroglial neoplasms. Histol Histopathol. 2005;20:1173-7 pubmed publisher
    ..Differentiated embryo-chondrocyte expressed gene 1 (DEC1) has been described as novel hypoxia-related tissue factor...
  59. Qian Y, Zhang J, Jung Y, Chen X. DEC1 coordinates with HDAC8 to differentially regulate TAp73 and ?Np73 expression. PLoS ONE. 2014;9:e84015 pubmed publisher
    ..Here, we reported that transcriptional factor DEC1, a target of the p53 family, exerts a distinct control of TAp73 and ?Np73 expression...
  60. Wu Y, Sato F, Bhawal U, Kawamoto T, Fujimoto K, Noshiro M, et al. Basic helix-loop-helix transcription factors DEC1 and DEC2 regulate the paclitaxel-induced apoptotic pathway of MCF-7 human breast cancer cells. Int J Mol Med. 2011;27:491-5 pubmed publisher
    Differentiated embryonic chondrocyte gene (DEC) 1 (BHLHE40/Stra13/Sharp2) and DEC2 (BHLHE41/Sharp1) are basic helix-loop-helix (bHLH) transcription factors that are associated with the regulation of apoptosis, cell proliferation and ..
  61. Seuter S, Pehkonen P, Heikkinen S, Carlberg C. The gene for the transcription factor BHLHE40/DEC1/stra13 is a dynamically regulated primary target of the vitamin D receptor. J Steroid Biochem Mol Biol. 2013;136:62-7 pubmed publisher
    The basic helix-loop-helix protein BHLHE40 functions as a transcriptional repressor and is involved in the control of cellular growth, development and circadian rhythms...
  62. Hiramoto K, Yamate Y, Yokoyama S. Ultraviolet A Eye Irradiation Ameliorates Atopic Dermatitis via p53 and Clock Gene Proteins in NC/Nga Mice. Photochem Photobiol. 2017;: pubmed publisher
    ..the levels of thymic stromal lymphopoetin (TSLP), period 2 (PER2), and differentiated embryo chondrocytes 1 (DEC1) protein were decreased in mice treated with UVA irradiation...
  63. Wu T, Fu Z. Time-dependent glucocorticoid administration differently affects peripheral circadian rhythm in rats. Acta Biochim Biophys Sin (Shanghai). 2017;49:1122-1128 pubmed publisher
    ..Real-time RT-PCR analysis indicated that the transcript levels of Per1 and Dec1 were rapidly up-regulated within 0...
  64. Soria V, Martínez Amorós E, Escaramis G, Valero J, Pérez Egea R, Garcia C, et al. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. Neuropsychopharmacology. 2010;35:1279-89 pubmed publisher
    ..We examined 209 single-nucleotide polymorphisms (SNPs) covering 19 circadian genes (ADCYAP1, ARNTL, ARNTL2, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1E, DBP, NPAS2, NR1D1, PER1, PER2, PER3, RORA, TIMELESS, VIP, and VIPR2) in a ..
  65. Wiencke J, Butler R, Hsuang G, Eliot M, Kim S, Sepulveda M, et al. The DNA methylation profile of activated human natural killer cells. Epigenetics. 2016;11:363-80 pubmed publisher
    ..Twenty-one loci were designated high priority and further investigated as potential markers of NK activation. BHLHE40 was identified as a viable candidate for which a droplet digital PCR assay for demethylation was developed...
  66. Zhou H, Cui X, Yuan H, Zhang B, Meng C, Zhao D. Effects of distinct drugs on gene transcription in an osteosarcoma cell line. Oncol Lett. 2017;14:4694-4700 pubmed publisher
    ..p53 regulated various genes including EHF, HOXA10 and BHLHE40 in the Nutlin-3 treatment group, whereas p53 regulated EHF, RFX3, TRAF40 and TCF7L2 in ..
  67. Wang Y, Rao V, Kok W, Roy D, Sethi S, Ling B, et al. SUMO modification of Stra13 is required for repression of cyclin D1 expression and cellular growth arrest. PLoS ONE. 2012;7:e43137 pubmed publisher
    b>Stra13, a basic helix-loop-helix (bHLH) transcription factor is involved in myriad biological functions including cellular growth arrest, differentiation and senescence...
  68. Shang W, Liu J, Chen R, Ning R, Xiong J, Liu W, et al. Fluoxetine reduces CES1, CES2, and CYP3A4 expression through decreasing PXR and increasing DEC1 in HepG2 cells. Xenobiotica. 2016;46:393-405 pubmed publisher
    ..the target genes such as CYP3A4, whereas increased the differentiated embryonic chondrocyte-expressed gene 1 (DEC1) expression. 3. FLX repressed the PXR at transcriptional level. 4...
  69. Zhu Z, Wang Y, Ge D, Lu M, Liu W, Xiong J, et al. Downregulation of DEC1 contributes to the neurotoxicity induced by MPP+ by suppressing PI3K/Akt/GSK3β pathway. CNS Neurosci Ther. 2017;23:736-747 pubmed publisher
    Differentiated embryonic chondrocyte gene 1 (DEC1) is involved in the neuronal differentiation and development...
  70. Lavebratt C, Sjöholm L, Partonen T, Schalling M, Forsell Y. PER2 variantion is associated with depression vulnerability. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:570-581 pubmed publisher
    ..In conclusion, genetic variation in PER2 is associated with depression vulnerability a Swedish population-based sample. More studies are needed to determine if this is the case also for NPAS2, ARNTL, and RORA. ..
  71. Jia Y, Hu R, Li P, Zheng Y, Wang Y, Ma X. DEC1 is required for anti-apoptotic activity of gastric cancer cells under hypoxia by promoting Survivin expression. Gastric Cancer. 2018;21:632-642 pubmed publisher
    Human differentiated embryonic chondrocyte-expressed gene 1 (DEC1), which has been reported to be overexpressed in several types of cancer, is associated with tumorigenesis through participation in several biological processes...
  72. Xu Q, Ma P, Hu C, Chen L, Xue L, Wang Z, et al. Overexpression of the DEC1 protein induces senescence in vitro and is related to better survival in esophageal squamous cell carcinoma. PLoS ONE. 2012;7:e41862 pubmed publisher
    ..Human differentiated embryo chondrocyte expressed gene 1 (Dec1) is an important transcription factor that related to senescence...