BEX1

Summary

Gene Symbol: BEX1
Description: brain expressed X-linked 1
Alias: BEX2, HBEX2, HGR74-h, protein BEX1, brain-expressed X-linked protein 1, ovarian granulosa cell 13.0 kDa protein hGR74
Species: human
Products:     BEX1

Top Publications

  1. Han C, Liu H, Liu J, Yin K, Xie Y, Shen X, et al. Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex. Nucleic Acids Res. 2005;33:6555-65 pubmed
    Human Bex2 (brain expressed X-linked, hBex2) is highly expressed in the embryonic brain, but its function remains unknown...
  2. Foltz G, Ryu G, Yoon J, Nelson T, Fahey J, Frakes A, et al. Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. Cancer Res. 2006;66:6665-74 pubmed
    ..We identified two novel brain expressed genes, BEX1 and BEX2, which were silenced in all tumor specimens and exhibited extensive promoter hypermethylation...
  3. Alvarez E, Zhou W, Witta S, Freed C. Characterization of the Bex gene family in humans, mice, and rats. Gene. 2005;357:18-28 pubmed
    ..most commonly identified genes in these screens were members of the Bex (Brain expressed X-linked) gene family, rat Bex1 (Rex3), and a novel gene, rat Bex4...
  4. Winter E, Ponting C. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. BMC Evol Biol. 2005;5:54 pubmed
    ..These findings have implications for the identification of non protein-coding regulatory elements and their lineage-specific evolution in mammals. ..
  5. Xiao Q, Hu Y, Liu Y, Wang Z, Geng H, Hu L, et al. BEX1 promotes imatinib-induced apoptosis by binding to and antagonizing BCL-2. PLoS ONE. 2014;9:e91782 pubmed publisher
    ..We have previously demonstrated that brain expressed X-linked 1 (BEX1) was silenced in secondary imatinib-resistant K562 cells and that re-expression of BEX1 can restore imatinib ..
  6. Quentmeier H, Tonelli R, Geffers R, Pession A, Uphoff C, Drexler H. Expression of BEX1 in acute myeloid leukemia with MLL rearrangements. Leukemia. 2005;19:1488-9 pubmed
  7. Vilar M, Murillo Carretero M, Mira H, Magnusson K, Besset V, Ibanez C. Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle. EMBO J. 2006;25:1219-30 pubmed
    ..for intracellular interactors of the p75 neurotrophin receptor (p75NTR) identified brain-expressed X-linked 1 (Bex1), a small adaptor-like protein of unknown function...
  8. Ding K, Su Y, Pang L, Lu Q, Wang Z, Zhang S, et al. Inhibition of apoptosis by downregulation of hBex1, a novel mechanism, contributes to the chemoresistance of Bcr/Abl+ leukemic cells. Carcinogenesis. 2009;30:35-42 pubmed publisher
    ..These data provide evidence that expression of hBex1 in leukemic cells is a novel mechanism by which chemoresistance is achieved and suggests that hBex1 is a potential molecular target for the development of novel leukemia treatments. ..
  9. Lee C, Wong T, Chan J, Lu S, Lin P, Cheng A, et al. Epigenetic regulation of the X-linked tumour suppressors BEX1 and LDOC1 in oral squamous cell carcinoma. J Pathol. 2013;230:298-309 pubmed publisher
    ..We identified BEX1 and LDOC1 as two epigenetically silenced X-linked tumour suppressors and demonstrated a functional link between the ..

More Information

Publications37

  1. Karakoula K, Jacques T, Phipps K, Harkness W, Thompson D, Harding B, et al. Epigenetic genome-wide analysis identifies BEX1 as a candidate tumour suppressor gene in paediatric intracranial ependymoma. Cancer Lett. 2014;346:34-44 pubmed publisher
    ..The most frequently methylated genes were BEX1 (27/40 cases), BAI2 (20/40), CCND2 (18/40), and CDKN2A (14/40)...
  2. Baldisseri D, Margolis J, Weber D, Koo J, Margolis F. Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction. J Mol Biol. 2002;319:823-37 pubmed
    ..a peptide titration series, we have identified this cleft as the binding surface for a peptide derived from the Bex1 protein...
  3. Behrens M, Margolis J, Margolis F. Identification of members of the Bex gene family as olfactory marker protein (OMP) binding partners. J Neurochem. 2003;86:1289-96 pubmed
    ..Here we report the identification of an OMP partner, Bex2, by phage-display screening of an olfactory mucosal cDNA-library...
  4. Yang Q, Xia F, Gu S, Yuan H, Chen J, Yang Q, et al. Cloning and expression pattern of a spermatogenesis-related gene, BEX1, mapped to chromosome Xq22. Biochem Genet. 2002;40:1-12 pubmed
    Through screening a human fetal brain cDNA library, a cDNA similar to the mouse Bex1 was isolated. This new gene was named brain expressed X-linked protein 1 (BEX1). Northern blot analysis revealed a 1...
  5. Naderi A. Molecular Functions of Brain Expressed X-Linked 2 (BEX2) in Malignancies. Exp Cell Res. 2019;: pubmed publisher
    Over the last decade there has been growing evidence that Brain Expressed X-Linked 2 (BEX2) has a significant role in the process of carcinogenesis...
  6. Schwarz B, Cetinbaş M, Clement K, Walsh R, Cheloufi S, Gu H, et al. Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming. Cell Stem Cell. 2018;23:289-305.e5 pubmed publisher
    ..Analysis of these cells uncovered transcription factors (e.g., Tfap2c and Bex2) that are important for reprogramming but dispensable for pluripotency maintenance...
  7. Rabinovich R, Drost E, Manning J, Dunbar D, Díaz Ramos M, Lakhdar R, et al. Genome-wide mRNA expression profiling in vastus lateralis of COPD patients with low and normal fat free mass index and healthy controls. Respir Res. 2015;16:1 pubmed publisher
    ..Five of these genes (CDKN1A, GADD45A, PMP22, BEX2, CGREF1, CYR61), were associated with cell cycle arrest and growth regulation and had been previously identified in ..
  8. Abduljabbar R, Negm O, Lai C, Jerjees D, Al Kaabi M, Hamed M, et al. Clinical and biological significance of glucocorticoid receptor (GR) expression in breast cancer. Breast Cancer Res Treat. 2015;150:335-46 pubmed publisher
    ..In ER-positive tumours, GR was associated with other features of favourable outcome including FOXA1, GATA3 and BEX1 expression, while low GR expression was associated with high Ki67, p53 and CD71 expression...
  9. Gu Y, Wei W, Cheng Y, Wan B, Ding X, Wang H, et al. A pivotal role of BEX1 in liver progenitor cell expansion in mice. Stem Cell Res Ther. 2018;9:164 pubmed publisher
    ..Hepatic brain-expressed X-linked 1 (BEX1) expression was evaluated using microarray screening, real-time polymerase chain reaction, immunoblotting and ..
  10. Ito K, Yamazaki S, Yamamoto R, Tajima Y, Yanagida A, Kobayashi T, et al. Gene targeting study reveals unexpected expression of brain-expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice. J Biol Chem. 2014;289:29892-911 pubmed publisher
    ..Here, we focused on Bex2 and examined its role and expression pattern by generating knock-in mice; the enhanced green fluorescence protein (..
  11. Nie E, Zhang X, Xie S, Shi Q, Hu J, Meng Q, et al. Î’-catenin is involved in Bex2 down-regulation induced glioma cell invasion/migration inhibition. Biochem Biophys Res Commun. 2015;456:494-9 pubmed publisher
    Previously, we found that brain expressed X-linked gene 2 (Bex2) regulates the invasion/migration ability of glioma cells. However, the mechanism of this effect remains unknown...
  12. Hu Y, Xiao Q, Chen H, He J, Tan Y, Liu Y, et al. BEX2 promotes tumor proliferation in colorectal cancer. Int J Biol Sci. 2017;13:286-294 pubmed publisher
    b>BEX2 has been suggested to promote the tumor growth in breast cancer and glioblastoma, while inhibit the proliferation of glioma cells. Thus, the role of BEX2 in tumor was still in debate...
  13. He M, Wang Y, Shen J, Duan C, Lu X, Li J. Bex1 attenuates neuronal apoptosis in rat intracerebral hemorrhage model. Pathol Res Pract. 2018;214:527-535 pubmed publisher
    Brain expressed x-linked gene 1 (Bex1) which is at high levels in several populations of central nervous system (CNS) neurons, belongs to a family of small proteins of unknown function, playing roles as adaptors or modulators of ..
  14. Brea O, Alkorta I, Mó O, Yáñez M, Elguero J, Corral I. Exergonic and Spontaneous Production of Radicals through Beryllium Bonds. Angew Chem Int Ed Engl. 2016;55:8736-9 pubmed publisher
    ..R=CH3 , NH2 , OH, F, SiH3 , PH2 , SH, Cl, NO) bonds is dramatically favored by the association of the molecule with BeX2 (X=H and Cl) derivatives...
  15. Kazi J, Kabir N, Rönnstrand L. Brain-Expressed X-linked (BEX) proteins in human cancers. Biochim Biophys Acta. 2015;1856:226-33 pubmed publisher
    The Brain-Expressed X-linked (BEX) family proteins are comprised of five human proteins including BEX1, BEX2, BEX3, BEX4 and BEX5...
  16. Palam L, Gore J, Craven K, Wilson J, Korc M. Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma. Cell Death Dis. 2015;6:e1913 pubmed publisher
    ..Gem also induced the expression of the antiapoptotic factors Nupr1, BEX2, and Bcl2a1, whereas ISRIB reduced their expression...
  17. Sagawa H, Naiki Ito A, Kato H, Naiki T, Yamashita Y, Suzuki S, et al. Connexin 32 and luteolin play protective roles in non-alcoholic steatohepatitis development and its related hepatocarcinogenesis in rats. Carcinogenesis. 2015;36:1539-49 pubmed publisher
    ..Microarray analysis identified brain expressed, X-linked 1 (Bex1) as an upregulated gene in Cx32ΔTg rat liver...
  18. Jiang C, Wang J, Yue F, Kuang S. The brain expressed x-linked gene 1 (Bex1) regulates myoblast fusion. Dev Biol. 2016;409:16-25 pubmed publisher
    ..Here we identify brain expressed x-linked gene 1 (Bex1) as a transient, developmentally regulated gene involved in myoblast fusion...
  19. Gao W, Li J, Chen S, Chu C, Chan J, Wong T. Decreased brain-expressed X-linked 4 (BEX4) expression promotes growth of oral squamous cell carcinoma. J Exp Clin Cancer Res. 2016;35:92 pubmed publisher
    ..Expression level of BEX family members (BEX1-5) in OSCC tissues and the paired normal epithelial were examined...
  20. Lee J, Lee J, Go H, Lee C, Kim S, Kim H, et al. Oncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition. Cell Death Dis. 2016;7:e2336 pubmed publisher
    Five brain-expressed X-linked (BEX) gene members (BEX1-5) are arranged in tandem on chromosome X, and are highly conserved across diverse species. However, little is known about the function and role of BEX...
  21. Hu Z, Wang Y, Huang F, Chen R, Li C, Wang F, et al. Brain-expressed X-linked 2 Is Pivotal for Hyperactive Mechanistic Target of Rapamycin (mTOR)-mediated Tumorigenesis. J Biol Chem. 2015;290:25756-65 pubmed publisher
    ..However, the downstream effectors of mTOR remain largely elusive. Here we report that brain-expressed X-linked 2 (BEX2) is a novel downstream effector of mTOR...
  22. Brea O, Mó O, Yáñez M, Alkorta I, Elguero J. Creating σ-holes through the formation of beryllium bonds. Chemistry. 2015;21:12676-82 pubmed publisher
    ..CH3 OF, NO2 F, and NO3 F are unable to yield Fâ‹…â‹…â‹…Base halogen bonds, their complexes with BeX2 derivatives are able to yield such bonds...
  23. Fernandez E, Díaz Ceso M, Vilar M. Brain expressed and X-linked (Bex) proteins are intrinsically disordered proteins (IDPs) and form new signaling hubs. PLoS ONE. 2015;10:e0117206 pubmed publisher
    ..The family of Brain Expressed and X-linked (Bex) proteins consists of 5 members in humans (Bex1-5)...
  24. Li P, Ma K, Wu H, Wu Y, Li B. Isoflavones Induce BEX2-Dependent Autophagy to Prevent ATR-Induced Neurotoxicity in SH-SY5Y Cells. Cell Physiol Biochem. 2017;43:1866-1879 pubmed publisher
    ..Studies have shown that certain plant compounds can induce autophagy and prevent neuronal cell death. This prompted us to investigate plant compounds that might reduce the neurotoxic effects of ATR...
  25. Aleskandarany M, Abduljabbar R, Ashankyty I, Elmouna A, Jerjees D, Ali S, et al. Prognostic significance of androgen receptor expression in invasive breast cancer: transcriptomic and protein expression analysis. Breast Cancer Res Treat. 2016;159:215-27 pubmed publisher
    ..AR was associated with ER-related markers GATA3, FOXa1, RERG and BEX1. Negative association was observed with HER2, p53, Ki67, TK1, CD71 and AGTR1...
  26. Accornero F, Schips T, Petrosino J, Gu S, Kanisicak O, van Berlo J, et al. BEX1 is an RNA-dependent mediator of cardiomyopathy. Nat Commun. 2017;8:1875 pubmed publisher
    ..Very little is understood of this process in heart failure. Here, we show that BEX1 is a heart failure-induced gene functioning as an mRNA-associated protein that enhances expression of a subset of ..
  27. Huang F, Cai P, Wang Y, Zhou X, Chen H, Liao W, et al. Up-regulation of brain-expressed X-linked 2 is critical for hepatitis B virus X protein-induced hepatocellular carcinoma development. Oncotarget. 2017;8:65789-65799 pubmed publisher
    ..Here we revealed that the expression of Brain-expressed X-linked 2 (BEX2) and Osteopontin (OPN) were elevated in liver tissues of HBV transgenic mice and human HCC specimens...
  28. Lindblad O, Li T, Su X, Sun J, Kabir N, Levander F, et al. BEX1 acts as a tumor suppressor in acute myeloid leukemia. Oncotarget. 2015;6:21395-405 pubmed
    ..In this report, we identified BEX1 as a novel regulator of oncogenic FLT3-ITD-driven AML...