beta1 integrin


Gene Symbol: beta1 integrin
Description: integrin subunit beta 1
Alias: CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, integrin beta-1, glycoprotein IIa, integrin VLA-4 beta subunit, integrin beta 1, integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12), very late activation protein, beta polypeptide
Species: human
Products:     beta1 integrin

Top Publications

  1. Schaller M, Otey C, Hildebrand J, Parsons J. Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains. J Cell Biol. 1995;130:1181-7 pubmed
  2. Kaido T, Yebra M, Kaneto H, Cirulli V, Hayek A, Montgomery A. Impact of integrin-matrix interaction and signaling on insulin gene expression and the mesenchymal transition of human beta-cells. J Cell Physiol. 2010;224:101-11 pubmed publisher
    ..Inhibition of Src-, ERK-, or JNK-dependent signaling combined with the selective regulation of matrix exposure may ultimately facilitate the development of more effective beta-cell expansion protocols. ..
  3. Sroka I, Anderson T, McDaniel K, Nagle R, Gretzer M, Cress A. The laminin binding integrin alpha6beta1 in prostate cancer perineural invasion. J Cell Physiol. 2010;224:283-8 pubmed publisher
  4. Ju L, Zhou C, Li W, Yan L. Integrin beta1 over-expression associates with resistance to tyrosine kinase inhibitor gefitinib in non-small cell lung cancer. J Cell Biochem. 2010;111:1565-74 pubmed publisher
    ..All these data suggest that up-regulation of integrin ?1 might be an important factor for gefitinib resistance in NSCLC cell line PC9/AB2. ..
  5. Morello V, Cabodi S, Sigismund S, Camacho Leal M, Repetto D, Volante M, et al. ?1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells. Oncogene. 2011;30:4087-96 pubmed publisher
    ..Overall, these results show that ?1 integrin is an essential regulator of EGFR signaling and tumorigenic properties of lung cancer cells, and that its silencing might represent an adjuvant approach to anti-EGFR therapy. ..
  6. Pellinen T, Rantala J, Arjonen A, Mpindi J, Kallioniemi O, Ivaska J. A functional genetic screen reveals new regulators of ?1-integrin activity. J Cell Sci. 2012;125:649-61 pubmed publisher
    ..Our discovery of new regulators of ?1-integrin activity highlight the complexity of integrin activity regulation and provide a set of new genes involved in regulation of integrin function. ..
  7. Chang H, Chen C, Chou C, Liao Y, Huang M, Chen Y, et al. ?-1,4-Galactosyltransferase III enhances invasive phenotypes via ?1-integrin and predicts poor prognosis in neuroblastoma. Clin Cancer Res. 2013;19:1705-16 pubmed publisher
    ..Our findings suggest that B4GALT3 predicts an unfavorable prognosis for NB and may regulate invasive phenotypes through modulating glycosylation, degradation, and signaling of ?1-integrin in NB cells. ..
  8. Jokinen J, White D, Salmela M, Huhtala M, Kapyla J, Sipilä K, et al. Molecular mechanism of alpha2beta1 integrin interaction with human echovirus 1. EMBO J. 2010;29:196-208 pubmed publisher
    ..Thus, in its entry strategy EV1 seems to rely on the activation of signalling pathways that are dependent on alpha2beta1 clustering, but do not require the conformational regulation of the receptor. ..
  9. Lee M, Park J, Lee Y. Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin beta1-mediated paxillin and AKT activation. Oncol Rep. 2010;23:757-61 pubmed
    ..These results suggest that integrin beta1 sialylation may play a critical role in promoting adhesion of cancer cells by integrin beta1-mediated paxillin and AKT activation. ..

More Information

Publications123 found, 100 shown here

  1. Askari J, Tynan C, Webb S, Martin Fernandez M, Ballestrem C, Humphries M. Focal adhesions are sites of integrin extension. J Cell Biol. 2010;188:891-903 pubmed publisher
    ..These results demonstrate definitely that major quaternary rearrangements of beta1-integrin subunits occur in adherent cells and that conversion from a bent to extended form takes place at focal adhesions. ..
  2. Ke A, Shi G, Zhou J, Huang X, Shi Y, Ding Z, et al. CD151 amplifies signaling by integrin ?6?1 to PI3K and induces the epithelial-mesenchymal transition in HCC cells. Gastroenterology. 2011;140:1629-41.e15 pubmed publisher
    ..High expression levels of CD151 and ?6 promote invasiveness of HCC cells. Either of these proteins, or PI3K signaling, might be targets for therapeutics for subgroups of patients with HCC. ..
  3. Petricevic B, Vrbanec D, Jakic Razumovic J, Brcic I, Rabic D, Badovinac T, et al. Expression of Toll-like receptor 4 and beta 1 integrin in breast cancer. Med Oncol. 2012;29:486-94 pubmed publisher
    ..Therefore, we conclude that expression of these markers is of biological interest but appears to be of little additional use as predictive clinical marker. ..
  4. Pugh N, Simpson A, Smethurst P, de Groot P, Raynal N, Farndale R. Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood. Blood. 2010;115:5069-79 pubmed publisher
  5. Lobert V, Brech A, Pedersen N, Wesche J, Oppelt A, Malerød L, et al. Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes. Dev Cell. 2010;19:148-59 pubmed publisher
    ..Fibronectin and alpha 5 beta 1 integrin therefore are trafficked to lysosomes in a similar way to growth factors and their receptors. ..
  6. Benoit Y, Larrivée J, Groulx J, Stankova J, Vachon P, Beaulieu J. Integrin alpha8beta1 confers anoikis susceptibility to human intestinal epithelial crypt cells. Biochem Biophys Res Commun. 2010;399:434-9 pubmed publisher
    ..Consequently, alpha8beta1 is a prerequisite for the proper conduct of anoikis in normal HIECs, whereas its loss contributes to the illicit acquisition of anoikis resistance. ..
  7. Ramirez N, Zhang Z, Madamanchi A, Boyd K, O Rear L, Nashabi A, et al. The ???? integrin is a metastasis suppressor in mouse models and human cancer. J Clin Invest. 2011;121:226-37 pubmed publisher
    ..Thus, the ?2?1 integrin functionally inhibits breast tumor metastasis, and ?2 expression may serve as an important biomarker of metastatic potential and patient survival. ..
  8. Yu X, Wang F, Liu H, Adams G, Aikhionbare F, Liu D, et al. ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin ?1 recycling in cell migration. J Biol Chem. 2011;286:43735-47 pubmed publisher
    ..Taken together, these results suggest a novel function for ACAP4 in the regulation of cell migration through controlling integrin ?1 dynamics. ..
  9. Fujita M, Takada Y, Takada Y. Integrins ?v?3 and ?4?1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1. J Immunol. 2012;189:5809-19 pubmed publisher
    ..These findings suggest that K36E/R37E acts as a dominant-negative CX3CR1 antagonist and that FKN-CD/integrin interaction is a novel therapeutic target in inflammatory diseases. ..
  10. Lesniak D, Xu Y, Deschenes J, Lai R, Thoms J, Murray D, et al. Beta1-integrin circumvents the antiproliferative effects of trastuzumab in human epidermal growth factor receptor-2-positive breast cancer. Cancer Res. 2009;69:8620-8 pubmed publisher
    ..Our findings show that beta(1)-integrin provides a novel independent prognostic biomarker of trastuzumab response in HER-2-positive MBC patients and suggest a new target to augment the antiproliferative effects of trastuzumab. ..
  11. Wang D, Muller S, Amin A, Huang D, Su L, Hu Z, et al. The pivotal role of integrin ?1 in metastasis of head and neck squamous cell carcinoma. Clin Cancer Res. 2012;18:4589-99 pubmed publisher
    ..01). Finally, zymography results showed integrin ?1-affected HNSCC invasion by regulating MMP-2 activation. These findings indicate that integrin ?1 has a major impact on HNSCC prognosis through its regulation of metastasis. ..
  12. Redondo Muñoz J, Ugarte Berzal E, Terol M, Van Den Steen P, Hernández Del Cerro M, Roderfeld M, et al. Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain. Cancer Cell. 2010;17:160-72 pubmed publisher
    ..Our results establish that MMP/receptor binding induces intracellular survival signals and highlight the role of (pro)MMP-9 in B-CLL pathogenesis. ..
  13. Goel H, Underwood J, Nickerson J, Hsieh C, Languino L. Beta1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1. J Cell Physiol. 2010;224:210-7 pubmed publisher
    ..Our results indicate that the beta1/IGF-IR complex regulates expression of GLI1, which in turn promotes cancer cell proliferation in 3D cultures. ..
  14. Hayashida T, Jones J, Lee C, Schnaper H. Loss of beta1-integrin enhances TGF-beta1-induced collagen expression in epithelial cells via increased alphavbeta3-integrin and Rac1 activity. J Biol Chem. 2010;285:30741-51 pubmed publisher
    ..Together, our results indicate that decreasing ?1 chain causes ?v?3-integrin to become functionally dominant and promotes renal cell fibrogenesis via Rac1-mediated ERK activity. ..
  15. Allen M, Vaziri R, Green M, Chelala C, Brentnall A, Dreger S, et al. Clinical and functional significance of ?9?1 integrin expression in breast cancer: a novel cell-surface marker of the basal phenotype that promotes tumour cell invasion. J Pathol. 2011;223:646-58 pubmed publisher
  16. Izmailyan R, Hsao J, Chung C, Chen C, Hsu P, Liao C, et al. Integrin ?1 mediates vaccinia virus entry through activation of PI3K/Akt signaling. J Virol. 2012;86:6677-87 pubmed publisher
    ..In summary, our results show that the binding of vaccinia mature virus to cells mimics the outside-in activation process of integrin functions to facilitate vaccinia virus entry into HeLa cells. ..
  17. Meng Y, Eshghi S, Li Y, Schmidt R, Schaffer D, Healy K. Characterization of integrin engagement during defined human embryonic stem cell culture. FASEB J. 2010;24:1056-65 pubmed publisher
    ..Meng, Y., Eshghi, S., Li, Y. J., Schmidt, R., Schaffer, D. V., Healy, K. E. Characterization of integrin engagement during defined human embryonic stem cell culture. ..
  18. Oommen S, Gupta S, Vlahakis N. Vascular endothelial growth factor A (VEGF-A) induces endothelial and cancer cell migration through direct binding to integrin {alpha}9{beta}1: identification of a specific {alpha}9{beta}1 binding site. J Biol Chem. 2011;286:1083-92 pubmed publisher
    ..This interaction is biologically important because it mediates in vitro endothelial cell tube formation, wound healing, and cancer cell invasion. These novel findings identify EYP as a potential site for directed pharmacotherapy. ..
  19. Mitra A, Sawada K, Tiwari P, Mui K, Gwin K, Lengyel E. Ligand-independent activation of c-Met by fibronectin and ?(5)?(1)-integrin regulates ovarian cancer invasion and metastasis. Oncogene. 2011;30:1566-76 pubmed publisher
    ..These data suggest that fibronectin promotes ovarian cancer invasion and metastasis through an ?(5)?(1)-integrin/c-Met/FAK/Src-dependent signaling pathway, transducing signals through c-Met in an HGF/SF-independent manner. ..
  20. Fu B, Wu Z, Qin J. Effects of integrin ?6?1 on migration of hepatocellular carcinoma cells. Mol Biol Rep. 2011;38:3271-6 pubmed publisher
    ..But the ?6 subunit has minimal effect on pseudopod formation in response to type IV collagen. Therefore, the integrin ?6?1-mediated cell migration is, at least in part, through the regulation on the cell adhesion step. ..
  21. Kryczka J, Stasiak M, Dziki L, Mik M, Dziki A, Cierniewski C. Matrix metalloproteinase-2 cleavage of the ?1 integrin ectodomain facilitates colon cancer cell motility. J Biol Chem. 2012;287:36556-66 pubmed publisher
  22. van der Flier A, Kuikman I, Kramer D, Geerts D, Kreft M, Takafuta T, et al. Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits. J Cell Biol. 2002;156:361-76 pubmed
    ..These findings suggest that specific combinations of filamin mRNA splicing events modulate the organization of the actin cytoskeleton and the binding affinity for integrins. ..
  23. Morozevich G, Kozlova N, Cheglakov I, Ushakova N, Preobrazhenskaya M, Berman A. Implication of alpha5beta1 integrin in invasion of drug-resistant MCF-7/ADR breast carcinoma cells: a role for MMP-2 collagenase. Biochemistry (Mosc). 2008;73:791-6 pubmed
    ..These data suggest that alpha5beta1 controls invasion ability of these cells by regulating expression of MMP-2, which involves PI-3K and Erk1/2 protein kinase signaling. ..
  24. Mitsuzuka K, Handa K, Satoh M, Arai Y, Hakomori S. A specific microdomain ("glycosynapse 3") controls phenotypic conversion and reversion of bladder cancer cells through GM3-mediated interaction of alpha3beta1 integrin with CD9. J Biol Chem. 2005;280:35545-53 pubmed
    ..High GM3 level decreases tumor cell motility/invasiveness, whereas low GM3 level enhances tumor cell motility/invasiveness. Oncogenic transformation and its reversion can be explained through the difference in glycosynapse organization. ..
  25. Klein S, de Fougerolles A, Blaikie P, Khan L, Pepe A, Green C, et al. Alpha 5 beta 1 integrin activates an NF-kappa B-dependent program of gene expression important for angiogenesis and inflammation. Mol Cell Biol. 2002;22:5912-22 pubmed
    ..These results suggest that engagement of the alpha 5 beta 1 integrin promotes an NF-kappa B-dependent program of gene expression that coordinately regulates angiogenesis and inflammation. ..
  26. Kong F, Garcia A, Mould A, Humphries M, Zhu C. Demonstration of catch bonds between an integrin and its ligand. J Cell Biol. 2009;185:1275-84 pubmed publisher
    ..Thus, catch bond formation appears to involve force-assisted activation of the headpiece but not integrin extension. ..
  27. Benelli R, Mortarini R, Anichini A, Giunciuglio D, Noonan D, Montalti S, et al. Monocyte-derived dendritic cells and monocytes migrate to HIV-Tat RGD and basic peptides. AIDS. 1998;12:261-8 pubmed
    ..These same domains attract monocytes. The alpha vbeta3 and beta1 integrins are equally involved in Tat-induced monocyte migration, while the alpha vbeta3 integrin largely mediates the dendritic cell response to Tat. ..
  28. Ashton A, Cheng Y, Helisch A, Ware J. Thromboxane A2 receptor agonists antagonize the proangiogenic effects of fibroblast growth factor-2: role of receptor internalization, thrombospondin-1, and alpha(v)beta3. Circ Res. 2004;94:735-42 pubmed
  29. Calderwood D, Fujioka Y, de Pereda J, García Alvarez B, Nakamoto T, Margolis B, et al. Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc Natl Acad Sci U S A. 2003;100:2272-7 pubmed
    ..These data establish that short integrin beta tails interact with a large number of PTB domain-containing proteins through a structurally conserved mechanism. ..
  30. Sabri S, Jandrot Perrus M, Bertoglio J, Farndale R, Mas V, Debili N, et al. Differential regulation of actin stress fiber assembly and proplatelet formation by alpha2beta1 integrin and GPVI in human megakaryocytes. Blood. 2004;104:3117-25 pubmed
    ..Thus, proplatelet formation in human MKs could be tightly regulated by differential interactions with their collagen receptors. We propose that this interaction with collagen prevents proplatelet formation within the marrow. ..
  31. Balzac F, Belkin A, Koteliansky V, Balabanov Y, Altruda F, Silengo L, et al. Expression and functional analysis of a cytoplasmic domain variant of the beta 1 integrin subunit. J Cell Biol. 1993;121:171-8 pubmed
    We have previously described a variant form of the integrin beta 1 subunit (beta 1B)1 characterized by an altered sequence at the cytoplasmic domain...
  32. Scherberich A, Moog S, Haan Archipoff G, Azorsa D, Lanza F, Beretz A. Tetraspanin CD9 is associated with very late-acting integrins in human vascular smooth muscle cells and modulates collagen matrix reorganization. Arterioscler Thromb Vasc Biol. 1998;18:1691-7 pubmed
    ..We studied the changes in expression of CD9 and beta1-integrins (CD29, VLA) in human vascular smooth muscle cells (VSMCs) under in vitro culture conditions mimicking proliferative ..
  33. Lozahic S, Christiansen D, Manie S, Gerlier D, Billard M, Boucheix C, et al. CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans. Eur J Immunol. 2000;30:900-7 pubmed
    ..CD46 associated in part with several tetranspans and with all beta1 integrins that were tested (CD29/CD49a, CD29/CD49b, CD29/CD49c, CD29/CD49e, CD29/CD49f) but not with beta4 integrins...
  34. Tachibana I, Bodorova J, Berditchevski F, Zutter M, Hemler M. NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. J Biol Chem. 1997;272:29181-9 pubmed
    ..Also, two-color immunofluorescence showed that NAG-2 was co-localized with CD81 on the surface of spread HT1080 cells. These results confirm the presence of NAG-2 in specific TM4SF.TM4SF and TM4SF-integrin complexes. ..
  35. Stipp C, Kolesnikova T, Hemler M. EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5. J Cell Biol. 2003;163:1167-77 pubmed
    ..These results show how laterally associated EWI-2 might regulate alpha3beta1 function in disease and development, and demonstrate how tetraspanin proteins can assemble multiple nontetraspanin proteins into functional complexes. ..
  36. Galvez B, Matías Román S, Yanez Mo M, Sanchez Madrid F, Arroyo A. ECM regulates MT1-MMP localization with beta1 or alphavbeta3 integrins at distinct cell compartments modulating its internalization and activity on human endothelial cells. J Cell Biol. 2002;159:509-21 pubmed
    ..First, MT1-MMP is found at the intercellular contacts of confluent ECs grown on beta1 integrin-dependent matrix such as type 1 collagen (COL I), fibronectin (FN), or fibrinogen (FG), but not on gelatin (..
  37. Bouchard V, Harnois C, Demers M, Thibodeau S, Laquerre V, Gauthier R, et al. B1 integrin/Fak/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms. Apoptosis. 2008;13:531-42 pubmed publisher
    ..To this effect, the roles of beta1 integrin/Fak/Src signaling to the PI3-K/Akt-1, MEK/Erk, and p38 pathways, were investigated...
  38. Li J, Mayne R, Wu C. A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation. J Cell Biol. 1999;147:1391-8 pubmed
    ..We report the identification of a novel muscle-specific beta1 integrin binding protein (MIBP)...
  39. Brakebusch C, Fassler R. beta 1 integrin function in vivo: adhesion, migration and more. Cancer Metastasis Rev. 2005;24:403-11 pubmed
  40. Brancaccio M, Guazzone S, Menini N, Sibona E, Hirsch E, De Andrea M, et al. Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain. J Biol Chem. 1999;274:29282-8 pubmed
  41. Alon R, Feigelson S, Manevich E, Rose D, Schmitz J, Overby D, et al. Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain. J Cell Biol. 2005;171:1073-84 pubmed
  42. Fransvea E, Mazzocca A, Antonaci S, Giannelli G. Targeting transforming growth factor (TGF)-betaRI inhibits activation of beta1 integrin and blocks vascular invasion in hepatocellular carcinoma. Hepatology. 2009;49:839-50 pubmed publisher
    ..However, in the former, the intracytoplasmic tail of beta1 integrin is constitutively phosphorylated at threonine 788-789 and the extracellular part is conformationally activated...
  43. Schnapp L, Hatch N, Ramos D, Klimanskaya I, Sheppard D, Pytela R. The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin. J Biol Chem. 1995;270:23196-202 pubmed
  44. Hannigan G, Leung Hagesteijn C, Fitz Gibbon L, Coppolino M, Radeva G, Filmus J, et al. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature. 1996;379:91-6 pubmed
    ..We propose that ILK is a receptor-proximal protein kinase regulating integrin-mediated signal transduction. ..
  45. Yebra M, Montgomery A, Diaferia G, Kaido T, Silletti S, Perez B, et al. Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration. Dev Cell. 2003;5:695-707 pubmed
    ..These results provide evidence for the activation of epithelial cell adhesion and migration by a neural chemoattractant, and identify Netrin-1/integrin interactions as adhesive/guidance cues for epithelial cells. ..
  46. Belkin A, Zhidkova N, Balzac F, Altruda F, Tomatis D, Maier A, et al. Beta 1D integrin displaces the beta 1A isoform in striated muscles: localization at junctional structures and signaling potential in nonmuscle cells. J Cell Biol. 1996;132:211-26 pubmed
    ..These data indicate that beta 1D and beta 1A integrin isoforms are functionally similar with regard to integrin-mediated signaling. ..
  47. Cordes N, Seidler J, Durzok R, Geinitz H, Brakebusch C. beta1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury. Oncogene. 2006;25:1378-90 pubmed
    ..Elucidation of the molecular circuitry of prosurvival beta1-integrin-mediated signaling in tumor cells may promote the development of innovative molecular-targeted therapeutic antitumor strategies. ..
  48. Brandt D, Baarlink C, Kitzing T, Kremmer E, Ivaska J, Nollau P, et al. SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. Nat Cell Biol. 2009;11:557-68 pubmed publisher
    ..Functional analysis of the beta1-integrin gene strongly argues that SCAI is a novel transcriptional cofactor that controls gene expression downstream of Dia1 to dictate changes in cell invasive behaviour. ..
  49. Lee S, Hatakeyama S, Yu S, Bao X, Ohyama C, Khoo K, et al. Core3 O-glycan synthase suppresses tumor formation and metastasis of prostate carcinoma PC3 and LNCaP cells through down-regulation of alpha2beta1 integrin complex. J Biol Chem. 2009;284:17157-69 pubmed publisher
    ..alpha2beta1 integrin acquired core3 O-glycans in cells expressing core3 synthase with decreased maturation of beta1 integrin, leading to decreased levels of the alpha2beta1 integrin complex, decreased activation of focal adhesion ..
  50. Whittard J, Craig S, Mould A, Koch A, Pertz O, Engel J, et al. E-cadherin is a ligand for integrin alpha2beta1. Matrix Biol. 2002;21:525-32 pubmed
    ..These findings demonstrate that E-cadherin can interact with alpha2beta1 and suggest that heterotypic interactions between E-cadherin and integrins may be more common than originally thought. ..
  51. Yamada M, Sumida Y, Fujibayashi A, Fukaguchi K, Sanzen N, Nishiuchi R, et al. The tetraspanin CD151 regulates cell morphology and intracellular signaling on laminin-511. FEBS J. 2008;275:3335-51 pubmed publisher
  52. Besson A, Wilson T, Yong V. The anchoring protein RACK1 links protein kinase Cepsilon to integrin beta chains. Requirements for adhesion and motility. J Biol Chem. 2002;277:22073-84 pubmed
    ..Altogether, these results provide a novel mechanistic link between PKC activation and integrin-mediated adhesion and motility. ..
  53. Pankov R, Cukierman E, Clark K, Matsumoto K, Hahn C, Poulin B, et al. Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A. J Biol Chem. 2003;278:18671-81 pubmed
    ..The identification of Trp(775) as a specific site for integrin-mediated Akt signaling supports the concept of specificity of signaling along the integrin cytoplasmic domain. ..
  54. Takagi J, Strokovich K, Springer T, Walz T. Structure of integrin alpha5beta1 in complex with fibronectin. EMBO J. 2003;22:4607-15 pubmed
    ..This finding is corroborated by kinetic analysis of real-time binding data, which shows that the synergy site greatly enhances k(on) but has little effect on the stability or k(off) of the complex. ..
  55. Serru V, Le Naour F, Billard M, Azorsa D, Lanza F, Boucheix C, et al. Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions. Biochem J. 1999;340 ( Pt 1):103-11 pubmed
    ..Because all tetraspan-tetraspan associations are disrupted by digitonin, it is likely that the other tetraspans interact indirectly with integrins, through interactions with CD81 or CD151. ..
  56. Fujiwara H, Kikkawa Y, Sanzen N, Sekiguchi K. Purification and characterization of human laminin-8. Laminin-8 stimulates cell adhesion and migration through alpha3beta1 and alpha6beta1 integrins. J Biol Chem. 2001;276:17550-8 pubmed
  57. Redondo Muñoz J, Ugarte Berzal E, Garcia Marco J, Del Cerro M, Van Den Steen P, Opdenakker G, et al. Alpha4beta1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells. Blood. 2008;112:169-78 pubmed publisher
    ..Thus, we have identified alpha4beta1 and CD44v as a novel proMMP-9 cell surface docking complex and show that cell-associated MMP-9 may regulate B-CLL cell migration and arrest. ..
  58. Barillari G, Gendelman R, Gallo R, Ensoli B. The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence. Proc Natl Acad Sci U S A. 1993;90:7941-5 pubmed
    ..The results also suggest that RGD-recognizing integrins mediate the vascular cell-growth-promoting effect of Tat. ..
  59. Wang J, Zhang X, Groopman J. Stimulation of beta 1 integrin induces tyrosine phosphorylation of vascular endothelial growth factor receptor-3 and modulates cell migration. J Biol Chem. 2001;276:41950-7 pubmed
  60. Seales E, Shaikh F, Woodard Grice A, Aggarwal P, McBrayer A, Hennessy K, et al. A protein kinase C/Ras/ERK signaling pathway activates myeloid fibronectin receptors by altering beta1 integrin sialylation. J Biol Chem. 2005;280:37610-5 pubmed
    ..In consequence, the beta1 integrin subunit becomes hyposialylated, which stimulates the ligand binding activity of alpha5beta1 fibronectin ..
  61. Munnix I, Gilio K, Siljander P, Raynal N, Feijge M, Hackeng T, et al. Collagen-mimetic peptides mediate flow-dependent thrombus formation by high- or low-affinity binding of integrin alpha2beta1 and glycoprotein VI. J Thromb Haemost. 2008;6:2132-42 pubmed publisher
    ..By extension, high-affinity binding for alpha2beta1 can control the overall platelet-adhesive activity of native collagens. ..
  62. Sameni M, Dosescu J, Yamada K, Sloane B, Cavallo Medved D. Functional live-cell imaging demonstrates that beta1-integrin promotes type IV collagen degradation by breast and prostate cancer cells. Mol Imaging. 2008;7:199-213 pubmed
    ..This is the first study to demonstrate through functional live-cell imaging that downregulation of beta1-integrin expression and function reduces proteolysis of collagen IV by breast and prostate cancer cells. ..
  63. Bayless K, Meininger G, Scholtz J, Davis G. Osteopontin is a ligand for the alpha4beta1 integrin. J Cell Sci. 1998;111 ( Pt 9):1165-74 pubmed
    ..Leukocyte adhesion was inhibited by anti-integrin antibodies directed at either the alpha4 or beta1 integrin subunits but not by control antibodies directed to other integrins...
  64. Yokosaki Y, Matsuura N, Higashiyama S, Murakami I, Obara M, Yamakido M, et al. Identification of the ligand binding site for the integrin alpha9 beta1 in the third fibronectin type III repeat of tenascin-C. J Biol Chem. 1998;273:11423-8 pubmed
    ..These findings support the idea that this tripeptide motif serves as a ligand binding site for the alpha4/alpha9 subfamily of integrins. ..
  65. Schaapveld R, Borradori L, Geerts D, van Leusden M, Kuikman I, Nievers M, et al. Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180. J Cell Biol. 1998;142:271-84 pubmed
    ..Unfolding of the cytoplasmic domain may be part of a mechanism by which the interaction of beta4 with other hemidesmosomal components, e.g., BP180, is regulated. ..
  66. Mould A, Symonds E, Buckley P, Grossmann J, McEwan P, Barton S, et al. Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis. J Biol Chem. 2003;278:39993-9 pubmed
    ..Our data provide the first view of a complex between an integrin and a macromolecular ligand in solution, at a nominal resolution of approximately 10 A. ..
  67. Friedland J, Lee M, Boettiger D. Mechanically activated integrin switch controls alpha5beta1 function. Science. 2009;323:642-4 pubmed publisher
    ..In the context of tissues, this integrin switch connects cytoskeleton and extracellular matrix mechanics to adhesion-dependent motility and signaling pathways. ..
  68. Zhidkova N, Belkin A, Mayne R. Novel isoform of beta 1 integrin expressed in skeletal and cardiac muscle. Biochem Biophys Res Commun. 1995;214:279-85 pubmed
    ..A beta 1D-specific anti-peptide polyclonal antibody was prepared and immunoprecipitation of tissue extracts with subsequent immunoblotting showed expression of beta 1D isoform only in striated muscle cells. ..
  69. Schnapp L, Breuss J, Ramos D, Sheppard D, Pytela R. Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells. J Cell Sci. 1995;108 ( Pt 2):537-44 pubmed
    ..These results suggest that in adult mammalian tissues, alpha 8 is predominantly expressed in smooth muscle and smooth muscle-like contractile cells. ..
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    ..Thus, our data suggest that uPAR occupancy results in an interaction between uPAR and integrins and a potentiation of integrin-mediated signaling, which leads to enhanced cell migration. ..
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    Structural requirements for the beta1 integrin functions in cell adhesion, spreading and signaling have been well documented mainly for fibroblasts...
  72. Seales E, Jurado G, Singhal A, Bellis S. Ras oncogene directs expression of a differentially sialylated, functionally altered beta1 integrin. Oncogene. 2003;22:7137-45 pubmed
    ..receptor/ligand-binding assay, we show that purified, desialylated alpha1beta1 integrins have diminished collagen-binding capability, providing strong evidence that sialic acids play a causal role in regulating beta1 integrin function.
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    ..These studies therefore identify the alpha4beta1 integrin on SS RBCs as a CD47-activated receptor for TSP, VCAM-1, and plasma fibronectin, revealing novel binding characteristics of this integrin. ..
  74. Kloepper J, Hendrix S, Bodo E, Tiede S, Humphries M, Philpott M, et al. Functional role of beta 1 integrin-mediated signalling in the human hair follicle. Exp Cell Res. 2008;314:498-508 pubmed
    ..whether beta1 integrins play any role in the regulation of human hair growth and the expression pattern of beta1 integrin in the human pilosebaceous unit remains ill-defined...
  75. Yakubenko V, Lobb R, Plow E, Ugarova T. Differential induction of gelatinase B (MMP-9) and gelatinase A (MMP-2) in T lymphocytes upon alpha(4)beta(1)-mediated adhesion to VCAM-1 and the CS-1 peptide of fibronectin. Exp Cell Res. 2000;260:73-84 pubmed
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    Here, we report a direct interaction between the beta1 integrin cytoplasmic tail and Rab25, a GTPase that has been linked to tumor aggressiveness and metastasis...
  77. Mizuno H, Ogura M, Saito Y, Sekine W, Sano R, Gotou T, et al. Changes in adhesive and migratory characteristics of hepatocellular carcinoma (HCC) cells induced by expression of alpha3beta1 integrin. Biochim Biophys Acta. 2008;1780:564-70 pubmed
    ..These results strongly suggest that enhanced expression of alpha3beta1 integrin on HCC cells is directly involved in their malignant phenotypes such as invasion and metastasis. ..
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    ..These data show that rictor regulates the ability of ILK to promote Akt phosphorylation and cancer cell survival. ..
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    ..Furthermore, allogeneic bone marrow transplantation was shown to alleviate the symptoms of the disease. ..
  80. Sudhakar A, Sugimoto H, Yang C, Lively J, Zeisberg M, Kalluri R. Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins. Proc Natl Acad Sci U S A. 2003;100:4766-71 pubmed
    ..Collectively, such distinct properties of human tumstatin and human endostatin provide the first insight into their diverse antiangiogenic actions and argue for combining them for targeting tumor angiogenesis. ..
  81. Zhang W, Alt Holland A, Margulis A, Shamis Y, Fusenig N, Rodeck U, et al. E-cadherin loss promotes the initiation of squamous cell carcinoma invasion through modulation of integrin-mediated adhesion. J Cell Sci. 2006;119:283-91 pubmed
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    ..The structural features observed here may represent a general mechanism for integrin-ligand recognition. ..
  83. Cunningham S, Rodriguez J, Arrate M, Tran T, Brock T. JAM2 interacts with alpha4beta1. Facilitation by JAM3. J Biol Chem. 2002;277:27589-92 pubmed
  84. Artym V, Kindzelskii A, Chen W, Petty H. Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes: dependence on beta1 integrins and the cytoskeleton. Carcinogenesis. 2002;23:1593-601 pubmed
    ..Based on these findings, we speculate that formation of heterogeneous lytic domains in the invading membranes of LOX cells increases the efficiency of directed pericellular proteolysis. ..
  85. Karjalainen M, Kakkonen E, Upla P, Paloranta H, Kankaanpää P, Liberali P, et al. A Raft-derived, Pak1-regulated entry participates in alpha2beta1 integrin-dependent sorting to caveosomes. Mol Biol Cell. 2008;19:2857-69 pubmed publisher
    ..Our results together suggest that alpha2beta1 integrin clustering defines its own entry pathway that is Pak1 dependent but clathrin and caveolin independent and that is able to sort cargo to caveosomes. ..
  86. Sonnenberg A, Linders C, Modderman P, Damsky C, Aumailley M, Timpl R. Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8. J Cell Biol. 1990;110:2145-55 pubmed
    ..Cell adhesion to fragment P1 was affected by mAbs against the integrin beta 1 and beta 3 subunits and furthermore could be prevented completely by a synthetic peptide containing the Arg-..
  87. Cordes N, Blaese M, Meineke V, Van Beuningen D. Ionizing radiation induces up-regulation of functional beta1-integrin in human lung tumour cell lines in vitro. Int J Radiat Biol. 2002;78:347-57 pubmed
    ..Identification of such mechanisms will provide considerable insights into the understanding of tumorigenicity and metastatic phenotypes, possibly leading to new, optimized radiochemotherapeutic regimens. ..
  88. Klemke M, Weschenfelder T, Konstandin M, Samstag Y. High affinity interaction of integrin alpha4beta1 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) enhances migration of human melanoma cells across activated endothelial cell layers. J Cell Physiol. 2007;212:368-74 pubmed
    ..These data imply that only high affinity interactions between the integrin alpha4beta1 on melanoma cells and VCAM-1 on activated endothelial cells may enhance the metastatic capacity of human beta2/beta3-negative melanoma cells. ..
  89. Languino L, Ruoslahti E. An alternative form of the integrin beta 1 subunit with a variant cytoplasmic domain. J Biol Chem. 1992;267:7116-20 pubmed
    ..This variant beta 1 cytoplasmic tail may modulate integrin affinity and may provide additional modes for the transduction of extracellular signals and modulation of cytoskeletal organization by beta 1 integrins. ..
  90. Balzac F, Retta S, Albini A, Melchiorri A, Koteliansky V, Geuna M, et al. Expression of beta 1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motility. J Cell Biol. 1994;127:557-65 pubmed
    ..These data, together with our previous results, indicate that beta 1B interferes with beta 1A function when expressed in CHO cells resulting in a dominant negative effect on cell adhesion and migration. ..
  91. Yauch R, Kazarov A, Desai B, Lee R, Hemler M. Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151. J Biol Chem. 2000;275:9230-8 pubmed
    ..Finally, we demonstrated that both NH(2)- and COOH-terminal domains of CD151 are located on the inside of the plasma membrane, thus confirming a long suspected model of TM4SF protein topology. ..
  92. Arboleda M, Lyons J, Kabbinavar F, Bray M, Snow B, Ayala R, et al. Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res. 2003;63:196-206 pubmed
    ..Increased invasion by AKT2 was blocked by preincubation with an anti-beta1 integrin function blocking antibody, exposure to wortmannin, and by expression of phosphatase and tensin homologue ..