beta-catenin

Summary

Gene Symbol: beta-catenin
Description: catenin (cadherin-associated protein), beta 1, 88kDa
Alias: CTNNB, MRD19, armadillo
Species: human

Top Publications

  1. pmc Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
    Yingwei Mao
    Howard Hughes Medical Institute, Cambridge, MA 02139, USA
    Cell 136:1017-31. 2009
  2. ncbi Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    Chunming Liu
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell 108:837-47. 2002
  3. ncbi Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    P J Morin
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 275:1787-90. 1997
  4. ncbi Functional interaction of beta-catenin with the transcription factor LEF-1
    J Behrens
    Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    Nature 382:638-42. 1996
  5. ncbi Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    V Korinek
    Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
    Science 275:1784-7. 1997
  6. ncbi Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion
    Zhimin Lu
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cancer Cell 4:499-515. 2003
  7. pmc MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1
    Mohit Sachdeva
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    Cancer Res 70:378-87. 2010
  8. ncbi Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase
    Sebastien Taurin
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Biol Chem 281:9971-6. 2006
  9. pmc Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity
    Dexing Fang
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 282:11221-9. 2007
  10. ncbi P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin
    Liuqing Yang
    Department of Biology, Georgia State University, University Plaza, Atlanta, GA 30303, USA
    Cell 127:139-55. 2006

Detail Information

Publications311 found, 100 shown here

  1. pmc Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
    Yingwei Mao
    Howard Hughes Medical Institute, Cambridge, MA 02139, USA
    Cell 136:1017-31. 2009
    ..Together, these results implicate DISC1 in GSK3beta/beta-catenin signaling pathways and provide a framework for understanding how alterations in this pathway may contribute to the etiology of psychiatric disorders...
  2. ncbi Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    Chunming Liu
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell 108:837-47. 2002
    ..Our study uncovers distinct roles and steps of beta-catenin phosphorylation, identifies CKIalpha as a component in Wnt/beta-catenin signaling, and has implications to pathogenesis/therapeutics of human cancers and diabetes...
  3. ncbi Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    P J Morin
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 275:1787-90. 1997
    ..These results indicate that regulation of beta-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or beta-catenin...
  4. ncbi Functional interaction of beta-catenin with the transcription factor LEF-1
    J Behrens
    Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    Nature 382:638-42. 1996
    The cytoplasmic proteins beta-catenin of vertebrates and armadillo of Drosophila have two functions: they link the cadherin cell-adhesion molecules to the cytoskeleton, and they participate in the wnt/wingless signal pathway...
  5. ncbi Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    V Korinek
    Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
    Science 275:1784-7. 1997
    ..Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium...
  6. ncbi Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion
    Zhimin Lu
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cancer Cell 4:499-515. 2003
    ..We propose that EGF-induced negative regulation of caveolin-1 plays a central role in the complex cellular changes leading to metastasis...
  7. pmc MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1
    Mohit Sachdeva
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    Cancer Res 70:378-87. 2010
    ..Taken together, these results suggest that as a tumor suppressor, miR-145 inhibits not only tumor growth but also cell invasion and metastasis...
  8. ncbi Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase
    Sebastien Taurin
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Biol Chem 281:9971-6. 2006
    ..In conclusion, this study identifies a novel, noncanonical mechanism of modulation of beta-catenin signaling through direct phosphorylation of beta-catenin by PKA, promoting its interaction with CREB-binding protein...
  9. pmc Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity
    Dexing Fang
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 282:11221-9. 2007
    ..Phosphorylation of beta-catenin by AKT increases its transcriptional activity and promotes tumor cell invasion, indicating that AKT-dependent regulation of beta-catenin plays a critical role in tumor invasion and development...
  10. ncbi P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin
    Liuqing Yang
    Department of Biology, Georgia State University, University Plaza, Atlanta, GA 30303, USA
    Cell 127:139-55. 2006
    ..These data demonstrated a novel mechanism of phosphor-p68 in mediating the growth factor-induced EMT and uncovered a new pathway to promote beta-catenin nuclear translocation...
  11. ncbi Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin
    K Orford
    Lombardi Cancer Center, Georgetown University Medical Center, Washington, D C 20007, USA
    J Biol Chem 272:24735-8. 1997
    ..Mutation of a single serine within the ubiquitination targeting sequence prevents ubiquitination of beta-catenin. Mutations within the ubiquitination targeting sequence of beta-catenin may be oncogenic...
  12. ncbi Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer
    Ann Mårtensson
    Department of Medical Biosciences, Pathology, Umea University, SE 901 85 Umea, Sweden
    Oncol Rep 17:447-52. 2007
    ..01). Our results suggest that nuclear accumulation of beta-catenin in CRC is related to CIN and may be of prognostic importance. However, larger studies are needed to verify these findings...
  13. pmc Requirement of cell cycle and apoptosis regulator 1 for target gene activation by Wnt and beta-catenin and for anchorage-independent growth of human colon carcinoma cells
    Chen Yin Ou
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 284:20629-37. 2009
    ....
  14. ncbi Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover
    B R Henderson
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millenium Institute, Westmead NSW 2145, Australia
    Nat Cell Biol 2:653-60. 2000
    ..These findings suggest that wild-type APC controls the nuclear accumulation of beta-catenin by a combination of nuclear export and cytoplasmic degradation...
  15. ncbi Association of the APC tumor suppressor protein with catenins
    L K Su
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 262:1734-7. 1993
    ..A 27-residue fragment of APC containing a 15-amino acid repeat was sufficient for the interaction with the catenins. These results suggest an important link between tumor initiation and cell adhesion...
  16. ncbi Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
    Michael B Major
    Howard Hughes Medical Institute, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA
    Science 316:1043-6. 2007
    ..These data provide a possible mechanistic explanation for the tumor suppressor activity of WTX...
  17. ncbi Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells
    Jun Yang
    Sealy Center for Cancer Cell Biology and Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Biol Chem 281:17751-7. 2006
    ..The APC domains required for beta-catenin ubiquitination were analyzed. Our results suggest that APC regulates beta-catenin phosphorylation and ubiquitination by distinct domains and by separate molecular mechanisms...
  18. doi Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells
    Katrin Hoffmeyer
    Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
    Science 336:1549-54. 2012
    ..We uncover a previously unknown link between the stem cell and oncogenic potential whereby β-catenin regulates Tert expression, and thereby telomere length, which could be critical in human regenerative therapy and cancer...
  19. ncbi MUC1 and nuclear beta-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosis
    Stephan E Baldus
    Institute of Pathology, University of Cologne, Cologne, Germany
    Clin Cancer Res 10:2790-6. 2004
    ..We tried to elucidate the coexpression of both molecules in colorectal cancer to demonstrate possible correlations with clinical, pathological, and prognostic data...
  20. pmc The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation
    Ilse Timmerman
    Department of Molecular Cell Biology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands
    Mol Biol Cell 23:4212-25. 2012
    ....
  21. pmc p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction
    Jose Piedra
    Unitat de Biofisica, Departament de Bioquimica i Biologia Molecular, Facultat de Medicina, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Mol Cell Biol 23:2287-97. 2003
    ....
  22. pmc Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination
    Shin Ichiro Hino
    Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Mol Cell Biol 25:9063-72. 2005
    ..These results indicate that PKA inhibits the ubiquitination of beta-catenin by phosphorylating beta-catenin, thereby causing beta-catenin to accumulate and the Wnt signaling pathway to be activated...
  23. ncbi Mutations of the APC, beta-catenin, and axin 1 genes and cytoplasmic accumulation of beta-catenin in oral squamous cell carcinoma
    Soichi Iwai
    Department of Oral and Maxillofacial Surgery II, Osaka University Graduate School of Dentistry, 1 8, Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Cancer Res Clin Oncol 131:773-82. 2005
    ..To clarify the genetic alterations of components of the Wnt pathway in oral squamous cell carcinoma (SCC), we examined mutations in the APC, beta-catenin and Axin genes and subcellular localization of beta-catenin...
  24. pmc The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling
    Tohru Ishitani
    Department of Molecular Biology, Graduate School of Science, Nagoya University, Chikusa ku, Japan
    Mol Cell Biol 23:131-9. 2003
    ..These results suggest that the TAK1-NLK MAPK cascade is activated by the noncanonical Wnt-5a/Ca(2+) pathway and antagonizes canonical Wnt/beta-catenin signaling...
  25. pmc Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation
    Anna P Lam
    Department of Medicine, Division of Pulmonary and Critical Care, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Am J Respir Cell Mol Biol 45:915-22. 2011
    ..These findings indicate that activation of β-catenin signaling in pulmonary fibroblasts may be a common feature of lung fibrosis, contributing to fibroproliferative and migratory activities associated with the disease...
  26. doi Activation of beta-catenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis
    Liang Liu
    Department of Hepatobiliary and Pancreatic Surgery, Fudan University Cancer Hospital, Fudan University, Shanghai, PR China
    Clin Cancer Res 16:2740-50. 2010
    ..However, the association between beta-catenin and the proinvasive role of hypoxia remains unclear. We investigated the role of beta-catenin in the proinvasive consequences of hypoxia in HCC...
  27. pmc Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling
    Hasan Korkaya
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Biol 7:e1000121. 2009
    ....
  28. doi Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors
    Sebastien Gaujoux
    Service des Maladies Endocriniennes et Metaboliques, Hopital Cochin, 75014 Paris, France
    J Clin Endocrinol Metab 93:4135-40. 2008
    ..PRKAR1A mutations leading to cAMP pathway dysregulation are observed in primary pigmented nodular adrenocortical diseases (PPNADs) and some sporadic ACAs...
  29. ncbi Pax3 functions at a nodal point in melanocyte stem cell differentiation
    Deborah Lang
    Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 433:884-7. 2005
    ..Thus, a stem cell transcription factor can both determine cell fate and simultaneously maintain an undifferentiated state, leaving a cell poised to differentiate in response to external stimuli...
  30. doi Transcriptome analysis reveals that p53 and {beta}-catenin alterations occur in a group of aggressive adrenocortical cancers
    Bruno Ragazzon
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, INSERM, U1016, Paris, France
    Cancer Res 70:8276-81. 2010
    ..This study shows the important respective roles of p53 and β-catenin in ACC development, delineating subgroups of ACC with different tumorigenesis and outcomes...
  31. ncbi CTNNB1 mutations and beta-catenin expression in endometrial carcinomas
    Pilar Machin
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Hum Pathol 33:206-12. 2002
    Mutations in the beta-catenin gene (CTNNB 1) with abnormal nuclear accumulation of beta-catenin have recently been identified in endometrial carcinoma (EC). Their relationship with microsatellite instability (MI) is unclear...
  32. pmc Nuclear beta-catenin induces an early liver progenitor phenotype in hepatocellular carcinoma and promotes tumor recurrence
    Gudrun Zulehner
    Department of Internal Medicine I, Centre of Public Health, Medical University of Vienna, Vienna, Austria
    Am J Pathol 176:472-81. 2010
    ..These data suggest that activation of beta-catenin signaling causes dedifferentiation to malignant, immature hepatocyte progenitors and facilitates recurrence of human HCC after orthotopic liver transplantation...
  33. ncbi Diagnostic and prognostic impact of beta-catenin alterations in pediatric liver tumors
    Hiroaki Yamaoka
    Department of Surgery, Hiroshima University, Hiroshima, Japan
    Oncol Rep 15:551-6. 2006
    ..On the other hand, the expression of cyclin D1, a gene downstream of beta-catenin, might play a role in tumor progression...
  34. ncbi Beta-catenin is involved in insulin-like growth factor 1-mediated transactivation of the androgen receptor
    Meletios Verras
    Department of Urology, R135, Edwards Building, Stanford University School of Medicine, Stanford, California 94305 5328, USA
    Mol Endocrinol 19:391-8. 2005
    ..Moreover, using a pulse-chase experiment, we showed that IGF-I enhances the stability of beta-catenin in prostate cancer cells. Our findings delineate a novel pathway for IGF-I in modulating androgen signaling through beta-catenin...
  35. pmc E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
    J Hülsken
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Cell Biol 127:2061-9. 1994
    ..E-cadherin and also with the tumor suppressor gene product APC, and the Drosophila homologue of beta-catenin, armadillo, mediates morphogenetic signals...
  36. ncbi Crystal structure of a beta-catenin/Tcf complex
    T A Graham
    Department of Biological Structure University of Washington 98195, Seattle, WA, USA
    Cell 103:885-96. 2000
    ..three binding modules that runs antiparallel to beta-catenin along the positively charged groove formed by the armadillo repeats...
  37. pmc Beta-catenin mutations in cell lines established from human colorectal cancers
    M Ilyas
    Cancer Genetics and Immunology Laboratory, Imperial Cancer Research Fund, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 94:10330-4. 1997
    ....
  38. ncbi Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase
    Geng Wu
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell 11:1445-56. 2003
    ....
  39. pmc Active beta-catenin signaling is an inhibitory pathway for human immunodeficiency virus replication in peripheral blood mononuclear cells
    Anvita Kumar
    Rush University Medical Center, Department of Immunology Microbiology, 1735 W Harrison Street, 614 Cohn, Chicago, IL 60612, USA
    J Virol 82:2813-20. 2008
    ..Collectively, these data indicate that beta-catenin signaling is an intrinsic molecular pathway restricting HIV replication in PBMCs...
  40. pmc Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-catenin
    Joanne H Heaton
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Am J Pathol 181:1017-33. 2012
    ..Our results are consistent with a model in which dysregulation of one pathway may result in adrenal hyperplasia, but accumulation of a second or multiple alterations is necessary for tumorigenesis...
  41. pmc Wnt-5a-CKI{alpha} signaling promotes {beta}-catenin/E-cadherin complex formation and intercellular adhesion in human breast epithelial cells
    Catharina Medrek
    Cell and Experimental Pathology and Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Universitetssjukhuset Malmö Allmänna Sjukhus, 20502 Malmo, Sweden
    J Biol Chem 284:10968-79. 2009
    ....
  42. pmc Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor
    Hans R Widlund
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Dana 630, 44 Binney Street, Boston, MA 02115, USA
    J Cell Biol 158:1079-87. 2002
    ..Thus, beta-catenin regulation of MITF expression represents a tissue-restricted pathway that significantly influences the growth and survival behavior of this notoriously treatment-resistant neoplasm...
  43. pmc Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome
    Andrey I Khramtsov
    University of Chicago, Department of Medicine, Chicago, IL 60637, USA
    Am J Pathol 176:2911-20. 2010
    ....
  44. ncbi Assembly of the cadherin-catenin complex in vitro with recombinant proteins
    H Aberle
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    J Cell Sci 107:3655-63. 1994
    ..The reconstitution in vitro of the cadherin-catenin complex should allow the study of the interaction with signalling molecules and with the actin-based cytoskeleton...
  45. ncbi Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia
    Abderrahmane Kaidi
    Cancer Research UK Colorectal Tumour Biology Research Group, Department of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK
    Nat Cell Biol 9:210-7. 2007
    ..This study highlights the importance of the microenvironment in transcriptional regulation...
  46. doi Expression of Lgr5 in human colorectal carcinogenesis and its potential correlation with beta-catenin
    Xiang Shan Fan
    Department of Pathology, Affiliated Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, People s Republic of China
    Int J Colorectal Dis 25:583-90. 2010
    ..The aim of this study was to investigate if Lgr5 over-expression was correlated with human colorectal carcinogenesis and its potential correlation with beta-catenin...
  47. ncbi Linking beta-catenin to androgen-signaling pathway
    Fajun Yang
    Department of Surgery and Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5328, USA
    J Biol Chem 277:11336-44. 2002
    ..The ligand binding domain of AR and the NH(2) terminus combined with the first six armadillo repeats of beta-catenin were shown to be necessary for the interaction...
  48. doi E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer
    Otto Schmalhofer
    Department of Visceral Surgery, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany
    Cancer Metastasis Rev 28:151-66. 2009
    ....
  49. doi TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis
    Jiong Li
    Laboratory of Molecular Signalling, Division of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA 90095, USA
    Nat Cell Biol 10:160-9. 2008
    ..Our results unravel two new components required for nuclear beta-catenin function, and have important implications in developing new strategies for inhibiting Wnt-beta-catenin-mediated tumorigenesis...
  50. ncbi Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter
    Mohammed Filali
    Department of Anatomy and Cell Biology and the Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 277:33398-410. 2002
    ..In summary, these results provide evidence for transcriptional regulation of the LEF-1 promoter by Wnt and enhance the mechanistic understanding of Wnt/beta-catenin signaling in the regulation of LEF-1-dependent developmental processes...
  51. pmc Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands
    Kaname Kawajiri
    Research Institute for Clinical Oncology and Hospital, Saitama Cancer Center, 818 Komuro, Ina, Saitama, 362 0806, Japan
    Proc Natl Acad Sci U S A 106:13481-6. 2009
    ..These findings suggest that chemoprevention with naturally-occurring and chemically-designed AhR ligands can be used to successfully prevent intestinal cancers...
  52. ncbi Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential
    U Steinhusen
    Max Delbruck Center for Molecular Medicine, Department of Medical Oncology and Tumorimmunology, Robert Rossle Strasse 10, D 3092, Berlin, Germany
    J Biol Chem 275:16345-53. 2000
    Beta-catenin is a member of the Armadillo repeat protein family with a dual cellular function as a component of both the adherens junction complex and the Wnt/wingless signaling pathway...
  53. ncbi The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin
    S Taya
    Division of Signal Transduction, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 0101, Japan
    Genes Cells 4:757-67. 1999
    ..These observations prompted us to examine the possible Fam regulation of the stabilization of beta-catenin...
  54. ncbi Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
    M J Hart
    Onyx Pharmaceuticals, Richmond, California 94806, USA
    Curr Biol 8:573-81. 1998
    ..This suggests a possible link between Axin, the Wnt-1 signaling components beta-catenin and glycogen synthase kinase 3 beta (GSK3 beta), and APC...
  55. pmc Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction
    Laurence Levy
    Unité d Oncogenèse et Virologie Moléculaire INSERM U579, Institut Pasteur, 75015 Paris, France
    Mol Cell Biol 24:3404-14. 2004
    ..Thus, our results describe a new mechanism by which p300 might regulate beta-catenin transcriptional activity...
  56. ncbi Prognostic and diagnostic significance of beta-catenin nuclear immunostaining in colorectal cancer
    Sze Chuen Cesar Wong
    Biomedical Science, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
    Clin Cancer Res 10:1401-8. 2004
    ..Collectively, the present large-scale study has clearly addressed the clinical significance of beta-catenin nuclear translocation with respect to tumor progression, survival, and differential diagnosis...
  57. ncbi HIV-1 Vpu sequesters beta-transducin repeat-containing protein (betaTrCP) in the cytoplasm and provokes the accumulation of beta-catenin and other SCFbetaTrCP substrates
    Corinne Besnard-Guerin
    Institut Cochin, Department of Infectious Diseases, INSERM U567, CNRS UMR 8104, Université R Descartes Paris V, 27 rue du Faubourg St Jacques, 75014 Paris, France
    J Biol Chem 279:788-95. 2004
    ..These data suggest that Vpu is a strong competitive inhibitor of betaTrCP that impairs the degradation of SCFbetaTrCP substrates as long as Vpu has an intact phosphorylation motif and can bind to betaTrCP...
  58. pmc A protein knockdown strategy to study the function of beta-catenin in tumorigenesis
    Feng Cong
    Program in Cell Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    BMC Mol Biol 4:10. 2003
    ..Aberrant Wnt signaling, which results from mutations of either beta-catenin or adenomatous polyposis coli (APC), renders beta-catenin resistant to degradation, and has been associated with multiple types of human cancers...
  59. ncbi Wnt signaling in hepatocellular carcinoma: analysis of mutation and expression of beta-catenin, T-cell factor-4 and glycogen synthase kinase 3-beta genes
    Jian Cui
    Liver Cancer Institute, Medical Center of Fudan University, Shanghai, China
    J Gastroenterol Hepatol 18:280-7. 2003
    ..The goal of the present study was to investigate the mechanism of inappropriate activation of the Wnt pathway in hepatocarcinogenesis...
  60. ncbi Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells
    Chi Hoon Park
    Division of Chemistry and Molecular Engineering, Seoul National University, Seoul 151 742, Republic of Korea
    Biochem Biophys Res Commun 328:227-34. 2005
    ..Together, we suggest that quercetin is an excellent inhibitor of beta-catenin/Tcf signaling in SW480 cell lines, and the reduced beta-catenin/Tcf transcriptional activity is due to the decreased nuclear beta-catenin and Tcf-4 proteins...
  61. ncbi Prostaglandin E2 Stimulates the beta-catenin/T cell factor-dependent transcription in colon cancer
    Jinyi Shao
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 280:26565-72. 2005
    ....
  62. pmc Wnt/beta-catenin inhibits dental pulp stem cell differentiation
    E L Scheller
    Laboratory of Molecular Signaling, Department of Biologic and Materials Sciences, School of Dentistry, The University of Michigan, Ann Arbor, MI 48109, USA
    J Dent Res 87:126-30. 2008
    ..In conclusion, our results suggest that canonical Wnt signaling negatively regulates the odontoblast-like differentiation of DPSCs...
  63. pmc Pharmacological modulation of beta-catenin and its applications in cancer therapy
    Ravi Thakur
    Cell Death Research Laboratory, Division of Endocrinology, Central Drug Research Institute, Lucknow, India
    J Cell Mol Med 17:449-56. 2013
    ....
  64. doi Wnt/beta-catenin signaling in glioma
    Kailiang Zhang
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, 300052, People s Republic of China
    J Neuroimmune Pharmacol 7:740-9. 2012
    ..This review reveals new insights into the role of Wnt/beta-catenin signaling in gliomagenesis, and highlights new therapeutic approaches for glioma, based on the modulation of the Wnt/beta-catenin pathway...
  65. ncbi Downregulation of beta-catenin by p53 involves changes in the rate of beta-catenin phosphorylation and Axin dynamics
    Elina Levina
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Oncogene 23:4444-53. 2004
    ..These results suggest that p53 induces a faster mobilization of Axin into the degradation complex thereby enhancing beta-catenin turnover as part of a protective mechanism against the development of cancer...
  66. doi Role of TAZ as mediator of Wnt signaling
    Luca Azzolin
    Department of Biomedical Sciences, University of Padua School of Medicine, viale Colombo 3, 35126 Padua, Italy
    Cell 151:1443-56. 2012
    ..At the genome-wide level, a substantial portion of Wnt transcriptional responses is mediated by TAZ. TAZ activation is a general feature of Wnt signaling and is functionally relevant to mediate Wnt biological effects...
  67. doi β-catenin/Wnt signalling pathway in fibromatosis, metaplastic carcinomas and phyllodes tumours of the breast
    Magali Lacroix-Triki
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Mod Pathol 23:1438-48. 2010
    ..catenin nuclear expression should not be used as a single marker to differentiate fibromatosis from other spindle cell tumours of the breast...
  68. pmc Nuclear expression of β-catenin promotes RB stability and resistance to TNF-induced apoptosis in colon cancer cells
    Jinbo Han
    Moores UCSD Cancer Center, University of California San Diego, La Jolla, California 92093, USA
    Mol Cancer Res 11:207-18. 2013
    ..Together, these results suggest that nuclear β-catenin-dependent RB stabilization suppresses TNF-induced apoptosis in caspase-8-positive colon cancer cells...
  69. doi The Hippo pathway regulates Wnt/beta-catenin signaling
    Xaralabos Varelas
    Center for Systems Biology, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada
    Dev Cell 18:579-91. 2010
    ..These results uncover a cytoplasmic function of TAZ in regulating Wnt signaling and highlight the role of the Hippo pathway in coordinating morphogenetic signaling with growth control...
  70. pmc Osteopontin induces beta-catenin signaling through activation of Akt in prostate cancer cells
    Brian W Robertson
    Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA
    Exp Cell Res 316:1-11. 2010
    ..This work describes an important aspect of cancer progression induced by OPN...
  71. ncbi Frequent mutations of beta-catenin gene in sporadic secreting adrenocortical adenomas
    Mimi Tadjine
    Division of Endocrinology, Department of Medicine, Centre Hospitalier de l Universite de Montreal CHUM, Hotel Dieu, Montreal, Quebec, Canada
    Clin Endocrinol (Oxf) 68:264-70. 2008
    ..To better understand the role of Wnt/beta-catenin signalling in adrenocortical tumours, we performed mutational analysis of the beta-catenin gene...
  72. pmc Nuclear beta-catenin overexpression in metastatic sentinel lymph node is associated with synchronous liver metastasis in colorectal cancer
    Hongxia Cheng
    Department of Pathology, Provincial Hospital affiliated to Shandong University, Jinan 250021, Shandong, People s Republic of China
    Diagn Pathol 6:109. 2011
    ..The purpose of this study is to investigate whether nuclear beta-catenin overexpression in metastatic sentinel lymph node(s) [SLN(s)] is associated with synchronous liver metastasis...
  73. ncbi Beta-catenin affects androgen receptor transcriptional activity and ligand specificity
    C I Truica
    Lombardi Cancer Center, Georgetown University, Washington, DC 20007 2197, USA
    Cancer Res 60:4709-13. 2000
    ..The amount of beta-catenin in complex with AR was increased by androgen. These findings implicate beta-catenin in the regulation of AR function and support a role for beta-catenin mutations in the pathogenesis of prostate cancer...
  74. doi The intratumoral distribution of nuclear beta-catenin is a prognostic marker in colon cancer
    David Horst
    Pathologisches Institut der Ludwig Maximilians Universität, Munich, Germany
    Cancer 115:2063-70. 2009
    ..Herein, the authors investigated whether the intratumoral distribution of nuclear beta-catenin can serve as a prognostic marker for survival and tumor progression of stage IIA colon cancer patients...
  75. ncbi Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad
    Hirofumi Mizusaki
    Department of Developmental Biology, National Institute for Basic Biology, Myodaiji cho, Okazaki 444 8585, Japan
    Mol Endocrinol 17:507-19. 2003
    ..We thus conclude that Wnt4 signaling mediates the increased expression of Dax-1 as the ovary becomes sexually differentiated...
  76. ncbi Deregulated Wnt/beta-catenin program in high-risk neuroblastomas without MYCN amplification
    X Liu
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    Oncogene 27:1478-88. 2008
    ..Thus, high-risk NBs without MYCN amplification may deregulate MYC and other oncogenic genes via altered beta-catenin signaling providing a potential candidate pathway for therapeutic inhibition...
  77. ncbi Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein
    Sheri L Holmen
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Biochem Biophys Res Commun 328:533-9. 2005
    ..We found that Dkk1-Fz5, but not Dkk3-Fz5, potently synergized with LRP6 to activate signaling in a dishevelled-dependent manner...
  78. pmc NHERF links the N-cadherin/catenin complex to the platelet-derived growth factor receptor to modulate the actin cytoskeleton and regulate cell motility
    Christopher S Theisen
    Department of Biochemistry and Molecular Biology, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198 7696, USA
    Mol Biol Cell 18:1220-32. 2007
    ..These studies implicate N-cadherin and beta-catenin in cell migration via PDGF-R-mediated signaling through the scaffolding molecule NHERF...
  79. pmc Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling
    Arthit Chairoungdua
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Cell Biol 190:1079-91. 2010
    ..Thus, exosomal packaging and release of cytosolic proteins can modulate the activity of cellular signaling pathways...
  80. pmc LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element
    Daniel Hebenstreit
    Department of Molecular Biology, University of Salzburg, 5020 Salzburg, Austria
    J Biol Chem 283:22490-7. 2008
    ..Furthermore, we found that IL-4 stimulation possesses a negative effect on the expressions of LEF-1 and TCF-1 in primary T cells, suggesting a positive feedback effect of IL-4 on IL4 gene expression...
  81. doi Low membranous expression of beta-catenin and high mitotic count predict poor prognosis in endometrioid carcinoma of the ovary
    Daniel G Rosen
    Department of Pathology, Baylor College of Medicine, Houston, TX, USA
    Mod Pathol 23:113-22. 2010
    ..Our data suggest that there is a need to define a better grading system for ovarian endometrioid carcinoma. Molecular markers such as beta-catenin and mitotic count could aid in defining this grading system...
  82. ncbi [Influence of E-cadherin promoter methylation and mutation of beta-catenin on invasion and metastasis of nasopharyngeal carcinoma cells]
    Zhi Li
    Department of Pathology, Sun Yat sen Medical College, Zhong Shan University, Guangzhou 510089, China
    Zhonghua Zhong Liu Za Zhi 25:238-42. 2003
    ..To study the mechanism of invasion and metastasis in early nasopharyngeal carcinoma (NPC) in relation to E-cadherin promoter methylation and mutation in exon 3 of beta-catenin...
  83. doi Reduced membranous beta-catenin protein expression is associated with metastasis and poor prognosis in squamous cell carcinoma of the esophagus
    Po Kuei Hsu
    Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang Ming University, School of Medicine, Taipei, Taiwan
    J Thorac Cardiovasc Surg 135:1029-35. 2008
    ..The clinical relevance and prognostic significance of the expression of these proteins were also analyzed...
  84. pmc Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos
    H Yamamoto
    Department of Biochemistry, Hiroshima University School of Medicine, Japan
    Mol Cell Biol 18:2867-75. 1998
    ..These results indicate that Axil negatively regulates the Wnt signaling pathway by mediating GSK-3beta-dependent phosphorylation of beta-catenin, thereby inhibiting axis formation...
  85. ncbi Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin
    H Nakagawa
    Department of Genetics, Osaka University Medical School, Suita City, Japan
    Cancer Res 58:5176-81. 1998
    ..These results suggest that the APCL protein may be involved in the Wnt/Wingless signal pathway, and the identification of a novel relative of APC may provide new insights into the function of APC...
  86. pmc Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1
    Yoana N Dimitrova
    Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 285:13507-16. 2010
    ..Siah-1 and TBL1 were found to bind to the same armadillo repeat domain of beta-catenin, suggesting that polyubiquitination of beta-catenin is regulated by competition ..
  87. doi Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth
    Ninib Baryawno
    Childhood Cancer Research Unit, Department of Women s and Children s Health, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 70:266-76. 2010
    ..These findings demonstrate the importance of cross-talk between the PI3K/Akt and beta-catenin pathways in medulloblastoma and rationalize the PI3K/Akt signaling pathway as a therapeutic target in treatment of this disease...
  88. ncbi Wnt signaling controls the phosphorylation status of beta-catenin
    Mascha van Noort
    Department of Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Biol Chem 277:17901-5. 2002
    ..Immunohistochemical analysis of mouse embryos utilizing the antibody visualizes sites that transduce Wnt signals through the canonical Wnt cascade...
  89. pmc Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes
    Ming Zhang
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 285:8703-10. 2010
    ..Our findings demonstrate a novel mechanism between TGF-beta and Wnt/beta-catenin signaling pathways during chondrocyte development...
  90. pmc Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex
    Zhong Hua Gao
    Department of Oncological Sciences, Huntsman Cancer Institute, 2000 East North Campus Drive, University of Utah, Salt Lake City, UT 84112 5550, USA
    Proc Natl Acad Sci U S A 99:1182-7. 2002
    ..The data suggest that CKI phosphorylates and destabilizes the beta-catenin degradation complex, likely through the dissociation of PP2A, providing a mechanism by which CKI stabilizes beta-catenin and propagates the Wnt signal...
  91. pmc Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization
    F Fagotto
    Division of Cell Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    J Cell Biol 145:741-56. 1999
    ..Coexpression of hemagglutinin-tagged Dishevelled (Dsh) revealed strong colocalization with Axin, suggesting that Dsh can interact with the Axin/APC/GSK3/beta-catenin complex, and may thus modulate its activity...
  92. ncbi Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses
    S I Matsuzawa
    The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell 7:915-26. 2001
    ..Expression of Siah is induced by p53, revealing a way of linking genotoxic injury to destruction of beta-catenin, thus reducing activity of Tcf/LEF transcription factors and contributing to cell cycle arrest...
  93. doi Involvement of the TGF-beta and beta-catenin pathways in pelvic lymph node metastasis in early-stage cervical cancer
    Maartje G Noordhuis
    Department of Gynecologic Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Cancer Res 17:1317-30. 2011
    ..Aim of this study was to identify cellular tumor pathways associated with pelvic lymph node metastasis in early-stage cervical cancer...
  94. pmc Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation
    Lilia Topol
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 162:899-908. 2003
    ..Furthermore, we provide evidence that Wnt-5a also acts in vivo to promote beta-catenin degradation in regulating mammalian limb development and possibly in suppressing tumor formation...
  95. pmc Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4
    Kathryn C Davidson
    Department of Pharmacology, Howard Hughes Medical Institute, and the Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 109:4485-90. 2012
    ..Together these data support a dominant role for Wnt/β-catenin signaling in the differentiation rather than self-renewal of hESCs...
  96. pmc Proteomic analysis identifies that 14-3-3zeta interacts with beta-catenin and facilitates its activation by Akt
    Qiang Tian
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 101:15370-5. 2004
    ..We propose that Akt phosphorylates beta-catenin, which results in 14-3-3zeta binding and stabilization of beta-catenin, and these interactions may be involved in stem cell development...
  97. pmc The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro
    J T Winston
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030 USA
    Genes Dev 13:270-83. 1999
    ..Our results suggest that an SCFbeta-TRCP complex functions in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway...
  98. doi Kaiso is a bimodal modulator for Wnt/beta-catenin signaling
    Hidekazu Iioka
    BRB 723, Department of Genetics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    FEBS Lett 583:627-32. 2009
    ..Our studies together provide insights into why Kaiso null mice display resistance to intestinal tumors when crossed onto an Apc(Min/+) background...
  99. pmc Transendothelial migration of melanoma cells involves N-cadherin-mediated adhesion and activation of the beta-catenin signaling pathway
    Jianfei Qi
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    Mol Biol Cell 16:4386-97. 2005
    ..Transendothelial migration was compromised in cells expressing a dominant-negative form of beta-catenin, thus supporting a regulatory role of beta-catenin signaling in this process...
  100. doi Nonstructural 5A protein activates beta-catenin signaling cascades: implication of hepatitis C virus-induced liver pathogenesis
    Chul Yong Park
    National Research Laboratory of Hepatitis C Virus and Ilsong Institute of Life Science, Hallym University, Dongan Gu, Anyang, Republic of Korea
    J Hepatol 51:853-64. 2009
    ..Wnt/beta-catenin signaling has also been involved in tumorigenesis. To elucidate the molecular mechanism of HCV pathogenesis, we examined the potential effects of HCV NS5A protein on Wnt/beta-catenin signal transduction cascades...
  101. pmc Tyrosine residues 654 and 670 in beta-catenin are crucial in regulation of Met-beta-catenin interactions
    Gang Zeng
    Department of Pathology CMP, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Exp Cell Res 312:3620-30. 2006
    ..Thus, intact 654 and 670 tyrosine residues in beta-catenin are crucial in HGF-mediated beta-catenin translocation, activation and mitogenesis...

Research Grants33

  1. Molecular Mechanisms of Disease Progression in Myeloid Malignancy
    ELIZABETH ANN EKLUND; Fiscal Year: 2013
    ..Targeting these mechanisms may lead to cure in CML by abolishing the CSC/LSC, and suggest therapeutic approaches to other forms of cancer with dysregulation of Fas and bcatenin. ..
  2. A Validated Resource of Thyroid Cancer Cell Lines for Pathway Discovery
    JEFFREY ALLEN KNAUF; Fiscal Year: 2010
    ....
  3. The role of ICSBP in the pathogenesis of chronic myeloid leukemia
    ELIZABETH ANN EKLUND; Fiscal Year: 2013
    ..The goal of these studies is to identify molecular mechanisms that lead to LSC persistence, and therefore TKI resistance and/or BC in CML. Targeting these mechanisms might cure CML by abolishing the LSC. ..
  4. Targeting beta-catenin in liver pathology: Novel Interactions, Novel Paradigms
    SATDARSHAN SINGH MONGA; Fiscal Year: 2013
    ..All the proposed studies in the grant will utilize a balance of i vitro and in vivo set of experiments and the expected outcomes will be highly relevant and translational. ..
  5. Smad4 promotes intestinal homeostasis through suppression of Wnt signaling
    Tanner J Freeman; Fiscal Year: 2013
    ..By knocking out Smad4 on the background of well-characterized mouse models with Apc mutations, this model closely recapitulates the pathogenesis of colorectal cancer. ..
  6. MSX2-Wnt Signaling in Cardiovascular Calcification
    Dwight A Towler; Fiscal Year: 2013
    ..physiological rationale and validation for reducing VSMC 2-catenin levels and LRP6 signaling as a potential therapeutic strategy to ameliorate vascular calcification -- and thus reduce lower extremity amputation risk in type II diabetes ..
  7. Role of Ectodermal Signals in Facial Prominence Outgrowth and Development
    Trevor J Williams; Fiscal Year: 2013
    ..abstract_text> ..
  8. GENES FROM THE FAP LOCUS
    Kenneth W Kinzler; Fiscal Year: 2013
    ..It can be argued that understanding these early changes is essential for the development of more effective strategies for colorectal tumor prevention and treatment. ..
  9. WT1 and beta-catenin targets in Wilms tumor
    Benjamin Tycko; Fiscal Year: 2007
    ..other phosphorylation sites in affecting the proliferative/oncogenic potency of beta-catenin. We will subsequently cross these mice with Wt1-mutant heterozygotes, possibly generating a mouse model for Wilms tumor. ..
  10. Deciphering Beta-Catenin Contributions in Prostate Cance
    David Mulholland; Fiscal Year: 2008
    ..These cells will be assessed for growth and PSA secretion in tumours carried as xenografts. These novel in vivo tools will allow understanding to the role of Beta-catenin has in Al PrCa. ..
  11. Role of CD164 in Skeletal Myogenesis
    ROBERT KRAUSS; Fiscal Year: 2008
    ..This research should therefore shed light on fundamental processes by which skeletal muscles develop. [unreadable] [unreadable]..
  12. PHENOTYPIC AND PSYCHOSOCIAL STUDY OF THE L1307K MUTATION
    Henry Lynch; Fiscal Year: 2004
    ....
  13. Gene-Environment Interaction in Holoprosencephaly: Role of Fetal Alcohol Exposure
    ROBERT KRAUSS; Fiscal Year: 2008
    ..Such information may have important public health impact and could ultimately aid in the counseling of HPE mutation carriers. [unreadable] [unreadable] [unreadable]..
  14. Restoration of beta-catenin signaling by perillyl alcoh*
    Wen Chi Chang; Fiscal Year: 2005
    ..Results from the proposed research will determine the feasibility of developing POH as a chemopreventive agent for patients with colorectal cancer and provide the basis for future R01 funding. ..
  15. MUCOSAL PROTECTIVE FACTORS IN HUMAN MILK
    Radhakrishna Rao; Fiscal Year: 2003
    ..protective factors in breast milk, and provide the basis for further characterization of the mechanisms involved in mucosal protection by breast milk, and their role in preventing neonatal gastrointestinal diseases ..
  16. RAS MEDIATED, ANCHORAGE INDEPENDENT GROWTH
    ROBERT KRAUSS; Fiscal Year: 2002
    ..Such genes represent potential mediators of the transformed phenotype. ..
  17. International Meeting--Epithelial /Mesenchymal Tranition
    Raghu Kalluri; Fiscal Year: 2005
    ..abstract_text> ..
  18. BIOLOGY OF BAMACAN IN TUMORIGENESIS
    Giancarlo Ghiselli; Fiscal Year: 2006
    ..3) The contribution of bamacan in vivo to colon tumorigenesis by generating transgenic mice over-expressing bamacan in the intestinal epithelium. ..
  19. The Neurotransmitter dopamine and angiogenesis
    Debabrata Mukhopadhyay; Fiscal Year: 2007
    ..abstract_text> ..
  20. Role of Fibroblasts in Cancer
    Raghu Kalluri; Fiscal Year: 2010
    ..The role of such fibroblasts in cancer progression and metastasis is unknown. This proposal addresses the role of fibroblasts in facilitating metastasis. ..
  21. Regulation and Function of MAPKAP Kinases
    Thomas Sturgill; Fiscal Year: 2005
    ..Aim four is to characterize the activation, enzymatic properties, and functions of MAPKAP kinase-like enzymes (Rcklp, Rck2p) in yeast, a model eukaryote, using combined biochemical and genetic approaches. ..
  22. Mice That Lack CDO: A Model for Mild Holoprosencephaly
    ROBERT KRAUSS; Fiscal Year: 2004
    ....
  23. ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE
    Raghu Kalluri; Fiscal Year: 2001
    ..Successful completion of this project should provide new experimental information regarding the processes that govern the pathogenesis of human anti-GBM disease. ..
  24. mTOR Signaling Pathways
    Thomas W Sturgill; Fiscal Year: 2010
    ..We will investigate novel candidate mTOR-interacting proteins identified by MS. Finally, to understand better the mechanisms involved in mTORC2, we propose to identify pianissimo-interacting proteins. ..
  25. Novel Therapeutic Strategies for PKD
    Patricia Wilson; Fiscal Year: 2007
    ..abstract_text> ..
  26. The Biology and Function of BMP-7 in the Kidney
    Raghu Kalluri; Fiscal Year: 2007
    ..The physiological role of BMP-7 in kidney health and pathology will be established. These studies will directly benefit the development of this molecule in the clinic as a drug for patients with kidney fibrosis. ..
  27. InteractiveSlides - Microarray data visualization tool
    Jozef Spychala; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  28. APC PATHWAY--A TARGET FOR CHEMOPREVENTIVE INTERVENTION
    Wen Chi Chang; Fiscal Year: 2005
    ..in nutritional biochemistry when combined with the proposed training in cancer prevention and molecular genetics will provide her with the unique ability to develop both natural and synthetic compounds as clinical chemopreventive agents ..
  29. Role of Plakophilin-1 in HNSCC
    James Wahl; Fiscal Year: 2009
    ..Plakophilin-1 is a member of the Armadillo (Arm) protein family that is a structural component of the cell-cell adhesion junction known as the desmosome...
  30. The role of PIKE-S in mediating EGFR mitogenic signaling in OSCC cells
    Zhongjian Xie; Fiscal Year: 2008
    ..Understanding these mechanisms will bring the possibility of new molecular targets for development novel therapeutic options for the control of oral squamous cell carcinoma. [unreadable] [unreadable] [unreadable]..
  31. Early Events in Colitis-Associated Colorectal Cancer
    Wen Chi Chang; Fiscal Year: 2003
    ..abstract_text> ..
  32. Matrix Microenvironment and Liver Fibrosis
    Raghu Kalluri; Fiscal Year: 2007
    ..Therefore, this application is well poised to identify a unique mechanism of liver fibrosis and also study a therapeutic agent, which works against this mechanism and inhibits progression of liver disease. ..
  33. Regulation of Angiogenesis by Tumstatin
    Raghu Kalluri; Fiscal Year: 2006
    ..abstract_text> ..