beta-catenin

Summary

Gene Symbol: beta-catenin
Description: catenin (cadherin-associated protein), beta 1, 88kDa
Alias: CTNNB, MRD19, armadillo, catenin beta-1
Species: human

Top Publications

  1. ncbi Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
    Yingwei Mao
    Howard Hughes Medical Institute, Cambridge, MA 02139, USA
    Cell 136:1017-31. 2009
  2. ncbi Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    V Korinek
    Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
    Science 275:1784-7. 1997
  3. ncbi Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion
    Zhimin Lu
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cancer Cell 4:499-515. 2003
  4. ncbi MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1
    Mohit Sachdeva
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    Cancer Res 70:378-87. 2010
  5. ncbi Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
    S Ikeda
    Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    EMBO J 17:1371-84. 1998
  6. ncbi Functional interaction of beta-catenin with the transcription factor LEF-1
    J Behrens
    Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    Nature 382:638-42. 1996
  7. ncbi Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses
    S I Matsuzawa
    The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell 7:915-26. 2001
  8. ncbi Requirement of cell cycle and apoptosis regulator 1 for target gene activation by Wnt and beta-catenin and for anchorage-independent growth of human colon carcinoma cells
    Chen Yin Ou
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 284:20629-37. 2009
  9. ncbi Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    Chunming Liu
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell 108:837-47. 2002
  10. ncbi Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model
    Andy J Chien
    Institute for Stem Cell and Regenerative Medicine, Department of Medicine, Division of Dermatology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 106:1193-8. 2009

Research Grants

  1. Role of Ectodermal Signals in Facial Prominence Outgrowth and Development
    Trevor J Williams; Fiscal Year: 2010
  2. MSX2-Wnt Signaling in Cardiovascular Calcification
    Dwight A Towler; Fiscal Year: 2010
  3. BETA-CATENIN AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CANCER
    SATDARSHAN MONGA; Fiscal Year: 2007
  4. BETA-CATENIN AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CANCER
    SATDARSHAN MONGA; Fiscal Year: 2009
  5. BETA-CATENIN AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CANCER
    SATDARSHAN SINGH MONGA; Fiscal Year: 2010
  6. WT1 and beta-catenin targets in Wilms tumor
    Benjamin Tycko; Fiscal Year: 2007
  7. Molecular Pathogenesis of Ovarian Endometrioid Adenocarcinomas
    KATHLEEN CHO; Fiscal Year: 2009
  8. Molecular Pathogenesis of Ovarian Endometrioid Adenocarc
    KATHLEEN CHO; Fiscal Year: 2006
  9. Molecular Pathogenesis of Ovarian Endometrioid Adenocarcinomas
    KATHLEEN CHO; Fiscal Year: 2007
  10. Molecular Pathogenesis of Ovarian Endometrioid Adenocarcinomas
    Kathleen R Cho; Fiscal Year: 2010

Detail Information

Publications223 found, 100 shown here

  1. ncbi Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
    Yingwei Mao
    Howard Hughes Medical Institute, Cambridge, MA 02139, USA
    Cell 136:1017-31. 2009
    ..Together, these results implicate DISC1 in GSK3beta/beta-catenin signaling pathways and provide a framework for understanding how alterations in this pathway may contribute to the etiology of psychiatric disorders...
  2. ncbi Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    V Korinek
    Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
    Science 275:1784-7. 1997
    ..Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium...
  3. ncbi Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion
    Zhimin Lu
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cancer Cell 4:499-515. 2003
    ..We propose that EGF-induced negative regulation of caveolin-1 plays a central role in the complex cellular changes leading to metastasis...
  4. ncbi MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1
    Mohit Sachdeva
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    Cancer Res 70:378-87. 2010
    ..Taken together, these results suggest that as a tumor suppressor, miR-145 inhibits not only tumor growth but also cell invasion and metastasis...
  5. ncbi Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
    S Ikeda
    Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    EMBO J 17:1371-84. 1998
    ..rAxin interacted directly with, and was phosphorylated by, GSK-3beta. rAxin also interacted directly with the armadillo repeats of beta-catenin...
  6. ncbi Functional interaction of beta-catenin with the transcription factor LEF-1
    J Behrens
    Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    Nature 382:638-42. 1996
    The cytoplasmic proteins beta-catenin of vertebrates and armadillo of Drosophila have two functions: they link the cadherin cell-adhesion molecules to the cytoskeleton, and they participate in the wnt/wingless signal pathway...
  7. ncbi Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses
    S I Matsuzawa
    The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell 7:915-26. 2001
    ..Expression of Siah is induced by p53, revealing a way of linking genotoxic injury to destruction of beta-catenin, thus reducing activity of Tcf/LEF transcription factors and contributing to cell cycle arrest...
  8. ncbi Requirement of cell cycle and apoptosis regulator 1 for target gene activation by Wnt and beta-catenin and for anchorage-independent growth of human colon carcinoma cells
    Chen Yin Ou
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 284:20629-37. 2009
    ....
  9. ncbi Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    Chunming Liu
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell 108:837-47. 2002
    ..Our study uncovers distinct roles and steps of beta-catenin phosphorylation, identifies CKIalpha as a component in Wnt/beta-catenin signaling, and has implications to pathogenesis/therapeutics of human cancers and diabetes...
  10. ncbi Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model
    Andy J Chien
    Institute for Stem Cell and Regenerative Medicine, Department of Medicine, Division of Dermatology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 106:1193-8. 2009
    ..Our results may explain the observed loss of nuclear beta-catenin with melanoma progression in human tumors, which could reflect a dysregulation of cellular differentiation through a loss of homeostatic Wnt/beta-catenin signaling...
  11. ncbi Diagnostic and prognostic impact of beta-catenin alterations in pediatric liver tumors
    Hiroaki Yamaoka
    Department of Surgery, Hiroshima University, Hiroshima, Japan
    Oncol Rep 15:551-6. 2006
    ..On the other hand, the expression of cyclin D1, a gene downstream of beta-catenin, might play a role in tumor progression...
  12. ncbi Nuclear beta-catenin induces an early liver progenitor phenotype in hepatocellular carcinoma and promotes tumor recurrence
    Gudrun Zulehner
    Department of Internal Medicine I, Centre of Public Health, Medical University of Vienna, Vienna, Austria
    Am J Pathol 176:472-81. 2010
    ..These data suggest that activation of beta-catenin signaling causes dedifferentiation to malignant, immature hepatocyte progenitors and facilitates recurrence of human HCC after orthotopic liver transplantation...
  13. ncbi E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
    J Hülsken
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Cell Biol 127:2061-9. 1994
    ..E-cadherin and also with the tumor suppressor gene product APC, and the Drosophila homologue of beta-catenin, armadillo, mediates morphogenetic signals...
  14. ncbi Beta-catenin is involved in insulin-like growth factor 1-mediated transactivation of the androgen receptor
    Meletios Verras
    Department of Urology, R135, Edwards Building, Stanford University School of Medicine, Stanford, California 94305 5328, USA
    Mol Endocrinol 19:391-8. 2005
    ..Moreover, using a pulse-chase experiment, we showed that IGF-I enhances the stability of beta-catenin in prostate cancer cells. Our findings delineate a novel pathway for IGF-I in modulating androgen signaling through beta-catenin...
  15. ncbi Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase
    Sebastien Taurin
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Biol Chem 281:9971-6. 2006
    ..In conclusion, this study identifies a novel, noncanonical mechanism of modulation of beta-catenin signaling through direct phosphorylation of beta-catenin by PKA, promoting its interaction with CREB-binding protein...
  16. ncbi β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation
    I Ahmad
    The Beatson Institute for Cancer Research, Glasgow, Scotland, UK
    Oncogene 30:178-89. 2011
    ..Taken together these data show that deregulated Wnt signalling has a critical role in promoting UCC, and suggests that human UCC that have high levels of Wnt and PI3 kinase signalling may be responsive to mTOR inhibition...
  17. ncbi Crystal structure of a beta-catenin/Tcf complex
    T A Graham
    Department of Biological Structure University of Washington 98195, Seattle, WA, USA
    Cell 103:885-96. 2000
    ..three binding modules that runs antiparallel to beta-catenin along the positively charged groove formed by the armadillo repeats...
  18. ncbi Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor
    Hans R Widlund
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Dana 630, 44 Binney Street, Boston, MA 02115, USA
    J Cell Biol 158:1079-87. 2002
    ..Thus, beta-catenin regulation of MITF expression represents a tissue-restricted pathway that significantly influences the growth and survival behavior of this notoriously treatment-resistant neoplasm...
  19. ncbi Assembly of the cadherin-catenin complex in vitro with recombinant proteins
    H Aberle
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    J Cell Sci 107:3655-63. 1994
    ..The reconstitution in vitro of the cadherin-catenin complex should allow the study of the interaction with signalling molecules and with the actin-based cytoskeleton...
  20. ncbi Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia
    Abderrahmane Kaidi
    Cancer Research UK Colorectal Tumour Biology Research Group, Department of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK
    Nat Cell Biol 9:210-7. 2007
    ..This study highlights the importance of the microenvironment in transcriptional regulation...
  21. ncbi Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome
    Andrey I Khramtsov
    University of Chicago, Department of Medicine, Chicago, IL 60637, USA
    Am J Pathol 176:2911-20. 2010
    ....
  22. ncbi Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
    Ilaria Malanchi
    Ecole Polytechnique Fédérale de Lausanne ISREC Swiss Institute for Experimental Cancer Research and National Center of Competence in Research Molecular Oncology, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Nature 452:650-3. 2008
    ..Because Wnt/beta-catenin signalling is not essential for normal epidermal homeostasis, such a mechanistic difference may thus be targeted to eliminate CSCs and consequently eradicate squamous cell carcinomas...
  23. ncbi Prognostic and diagnostic significance of beta-catenin nuclear immunostaining in colorectal cancer
    Sze Chuen Cesar Wong
    Biomedical Science, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
    Clin Cancer Res 10:1401-8. 2004
    ..Collectively, the present large-scale study has clearly addressed the clinical significance of beta-catenin nuclear translocation with respect to tumor progression, survival, and differential diagnosis...
  24. ncbi Low membranous expression of beta-catenin and high mitotic count predict poor prognosis in endometrioid carcinoma of the ovary
    Daniel G Rosen
    Department of Pathology, Baylor College of Medicine, Houston, TX, USA
    Mod Pathol 23:113-22. 2010
    ..Our data suggest that there is a need to define a better grading system for ovarian endometrioid carcinoma. Molecular markers such as beta-catenin and mitotic count could aid in defining this grading system...
  25. ncbi [Influence of E-cadherin promoter methylation and mutation of beta-catenin on invasion and metastasis of nasopharyngeal carcinoma cells]
    Zhi Li
    Department of Pathology, Sun Yat sen Medical College, Zhong Shan University, Guangzhou 510089, China
    Zhonghua Zhong Liu Za Zhi 25:238-42. 2003
    ..To study the mechanism of invasion and metastasis in early nasopharyngeal carcinoma (NPC) in relation to E-cadherin promoter methylation and mutation in exon 3 of beta-catenin...
  26. ncbi Transendothelial migration of melanoma cells involves N-cadherin-mediated adhesion and activation of the beta-catenin signaling pathway
    Jianfei Qi
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    Mol Biol Cell 16:4386-97. 2005
    ..Transendothelial migration was compromised in cells expressing a dominant-negative form of beta-catenin, thus supporting a regulatory role of beta-catenin signaling in this process...
  27. ncbi Reduced membranous beta-catenin protein expression is associated with metastasis and poor prognosis in squamous cell carcinoma of the esophagus
    Po Kuei Hsu
    Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang Ming University, School of Medicine, Taipei, Taiwan
    J Thorac Cardiovasc Surg 135:1029-35. 2008
    ..The clinical relevance and prognostic significance of the expression of these proteins were also analyzed...
  28. ncbi Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos
    H Yamamoto
    Department of Biochemistry, Hiroshima University School of Medicine, Japan
    Mol Cell Biol 18:2867-75. 1998
    ..These results indicate that Axil negatively regulates the Wnt signaling pathway by mediating GSK-3beta-dependent phosphorylation of beta-catenin, thereby inhibiting axis formation...
  29. ncbi Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth
    Ninib Baryawno
    Childhood Cancer Research Unit, Department of Women s and Children s Health, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 70:266-76. 2010
    ..These findings demonstrate the importance of cross-talk between the PI3K/Akt and beta-catenin pathways in medulloblastoma and rationalize the PI3K/Akt signaling pathway as a therapeutic target in treatment of this disease...
  30. ncbi Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1
    Yoana N Dimitrova
    Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 285:13507-16. 2010
    ..Siah-1 and TBL1 were found to bind to the same armadillo repeat domain of beta-catenin, suggesting that polyubiquitination of beta-catenin is regulated by competition ..
  31. ncbi Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin
    H Nakagawa
    Department of Genetics, Osaka University Medical School, Suita City, Japan
    Cancer Res 58:5176-81. 1998
    ..These results suggest that the APCL protein may be involved in the Wnt/Wingless signal pathway, and the identification of a novel relative of APC may provide new insights into the function of APC...
  32. ncbi Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers
    N Miwa
    Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Japan
    Oncol Res 12:469-76. 2001
    ..Our results imply that claudin-1 is involved in the beta-catenin-Tcf/LEF signaling pathway, and that increased expression of claudin-1 may have some role in colorectal tumorigenesis...
  33. ncbi ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas
    Joyce A Schroeder
    Tumor Biology Program and Department of Biochemistry and Molecular Biology, Mayo Medical Graduate School, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    J Biol Chem 277:22692-8. 2002
    ....
  34. ncbi Tyrosine residues 654 and 670 in beta-catenin are crucial in regulation of Met-beta-catenin interactions
    Gang Zeng
    Department of Pathology CMP, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Exp Cell Res 312:3620-30. 2006
    ..Thus, intact 654 and 670 tyrosine residues in beta-catenin are crucial in HGF-mediated beta-catenin translocation, activation and mitogenesis...
  35. ncbi Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes
    Satdarshan P S Monga
    Division of Cellular and Molecular Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Cancer Res 62:2064-71. 2002
    ..Part of the multifunctionality of HGF might be attributable to nuclear beta-catenin and the resulting target gene expression...
  36. ncbi Regulation of beta-catenin structure and activity by tyrosine phosphorylation
    J Piedra
    Unitat de Biologia Cel lular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    J Biol Chem 276:20436-43. 2001
    ..Phosphorylation of Tyr-654, a residue placed in the last armadillo repeat of beta-catenin, decreases its binding to E-cadherin...
  37. ncbi Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
    Michael B Major
    Howard Hughes Medical Institute, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA
    Science 316:1043-6. 2007
    ..These data provide a possible mechanistic explanation for the tumor suppressor activity of WTX...
  38. ncbi Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination
    Shin Ichiro Hino
    Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Mol Cell Biol 25:9063-72. 2005
    ..These results indicate that PKA inhibits the ubiquitination of beta-catenin by phosphorylating beta-catenin, thereby causing beta-catenin to accumulate and the Wnt signaling pathway to be activated...
  39. ncbi Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
    B Rubinfeld
    Onyx Pharmaceuticals, Richmond, CA 94806, USA
    Science 272:1023-6. 1996
    ..The APC protein binds to the cellular adhesion molecule beta-catenin, which is a mammalian homolog of ARMADILLO, a component of the WINGLESS signaling pathway in Drosophila development...
  40. ncbi Nuclear GSK-3beta inhibits the canonical Wnt signalling pathway in a beta-catenin phosphorylation-independent manner
    M Caspi
    Department of Anatomy and Anthropology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Oncogene 27:3546-55. 2008
    ..We show that GSK-3beta enters the nucleus, forms a complex with beta-catenin and lowers the levels of beta-catenin/TCF-dependent transcription in a mechanism that involves GSK-3beta-Axin binding...
  41. ncbi Correlation between beta-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma
    Madeleine Austinat
    Institute for Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    Mol Cancer 7:21. 2008
    ....
  42. ncbi Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene
    Benjamin Cieply
    Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 49:821-31. 2009
    ..Also, CTNNB1 mutations might lead to HCC in the absence of cirrhosis. Finally, FL-HCC cases display a unique up-regulation of tyrosine-phosphorylated-beta-catenin, suggesting robust receptor tyrosine kinase signaling in this tumor type...
  43. ncbi Pax3 functions at a nodal point in melanocyte stem cell differentiation
    Deborah Lang
    Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 433:884-7. 2005
    ..Thus, a stem cell transcription factor can both determine cell fate and simultaneously maintain an undifferentiated state, leaving a cell poised to differentiate in response to external stimuli...
  44. ncbi HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies
    Tomas Valenta
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    EMBO J 25:2326-37. 2006
    ..These data indicate that the intracellular amounts of HIC1 protein can modulate the level of the transcriptional stimulation of the genes regulated by canonical Wnt/beta-catenin signaling...
  45. ncbi EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin
    Haitao Ji
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Mol Cell 36:547-59. 2009
    ..This EGFR-ERK-CK2-mediated phosphorylation of alpha-catenin promotes beta-catenin transactivation and tumor cell invasion. These findings highlight the importance of the crosstalk between EGFR and Wnt pathways in tumor development...
  46. ncbi The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes
    Jose Sierra
    Regulatory Biology Laboratory, The Salk Insitute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 20:586-600. 2006
    ..We conclude that, in addition to regulating the stability of beta-cat, APC facilitates CtBP-mediated repression of Wnt target genes in normal, but not in colorectal cancer cells...
  47. ncbi Issues associated with assessing nuclear localization of N-terminally unphosphorylated beta-catenin with monoclonal antibody 8E7
    Meghan T Maher
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Biol Direct 4:5. 2009
    ....
  48. ncbi Activation of beta-catenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis
    Liang Liu
    Department of Hepatobiliary and Pancreatic Surgery, Fudan University Cancer Hospital, Fudan University, Shanghai, PR China
    Clin Cancer Res 16:2740-50. 2010
    ..However, the association between beta-catenin and the proinvasive role of hypoxia remains unclear. We investigated the role of beta-catenin in the proinvasive consequences of hypoxia in HCC...
  49. ncbi Target gene activation of the Wnt signaling pathway in nuclear beta-catenin accumulating cells of adamantinomatous craniopharyngiomas
    Annett Hölsken
    Departments of Neuropathology Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Brain Pathol 19:357-64. 2009
    ..The results confirm the Wnt signaling pathway as molecular basis of the distinct and challenging clinical and morphological phenotype of adaCP...
  50. ncbi Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
    Abdolrahman S Nateri
    Mammalian Genetics Laboratory, CR UK London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nature 437:281-5. 2005
    ..Therefore, the phosphorylation-dependent interaction between c-Jun and TCF4 regulates intestinal tumorigenesis by integrating JNK and APC/beta-catenin, two distinct pathways activated by WNT signalling...
  51. ncbi Reversal of melanocytic malignancy by keratinocytes is an E-cadherin-mediated process overriding beta-catenin signaling
    Gang Li
    The Wistar Institute, Philadelphia, PA 19104, USA
    Exp Cell Res 297:142-51. 2004
    ..The results indicate that E-cadherin-mediated cell adhesion is required for keratinocyte-mediated control of melanocytic cells, which can override proliferative activity of beta-catenin...
  52. ncbi Fas-associated factor 1 antagonizes Wnt signaling by promoting β-catenin degradation
    Long Zhang
    Department of Molecular Cell Biology and Center for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Mol Biol Cell 22:1617-24. 2011
    ..These results identify FAF1 as a novel inhibitory factor of canonical Wnt signaling pathway...
  53. ncbi Beta-catenin accumulation and mutation of the CTNNB1 gene in hepatoblastoma
    H Blaker
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    Genes Chromosomes Cancer 25:399-402. 1999
    ..Genes Chromosomes Cancer 25:399-402, 1999...
  54. ncbi Expression and clinical significance of Wnt-1 and beta-catenin in nasopharyngeal carcinoma
    Fei Li Wang
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, PR China
    Ai Zheng 28:72-5. 2009
    ..This study was to investigate the expression and clinical significance of Wnt-1 and beta-catenin in nasopharyngeal carcinoma (NPC)...
  55. ncbi Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma
    Gang Zeng
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neoplasia 8:279-89. 2006
    ..Thus, Wnt/beta-catenin activation was observed in 65% of pancreatic adenocarcinomas, independently of beta-catenin gene mutations in most tumors...
  56. ncbi Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression
    Diego A Rodriguez
    Fondo de Investigación Avanzada en Areas Prioritarias, Center for Molecular Studies of the Cell, Departmento de Cirugia, Hospital Clinico, Universidad de Chile, Santiago, Chile
    Mol Biol Cell 20:2297-310. 2009
    ....
  57. ncbi Enhanced interaction between focal adhesion and adherens junction proteins: involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement
    Xiaoguang Sun
    Department of Medicine, Division of Biological Sciences, The University of Chicago, 5841 Maryland Ave, Chicago, IL 60637 1470, USA
    Microvasc Res 77:304-13. 2009
    ..These results demonstrate a mechanism of S1P-induced endothelial barrier enhancement via beta-catenin-linked adherens junction and focal adhesion interaction...
  58. ncbi Sporadic childhood hepatoblastomas show activation of beta-catenin, mismatch repair defects and p53 mutations
    Maria C Curia
    Department of Oncology, University of Chieti Pescara, Chieti, Italy
    Mod Pathol 21:7-14. 2008
    ..Sporadic hepatoblastoma appears to be molecularly and phenotypically heterogeneous and may reflect different pathways of liver carcinogenesis...
  59. ncbi Endostatin induces autophagy in endothelial cells by modulating Beclin 1 and beta-catenin levels
    Tri Minh Bui Nguyen
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    J Cell Mol Med 13:3687-98. 2009
    ..Thus, interfering with autophagy can potentiate the effects of endostatin by promoting a switch to apoptosis...
  60. ncbi Expression of E-cadherin, beta-catenin and topoisomerase IIalpha in leiomyosarcomas
    Pinelopi N Gogou
    Department of Radiotherapy, University of Ioannina, Medical School, Ioannnina, Greece
    Clin Transl Oncol 11:548-51. 2009
    ..The expression of E-cadherin, beta-catenin and topoisomerase II has been associated with clinical outcome of several cancers including sarcomas. We aimed to evaluate the expression of these markers in leiomyosarcomas (LMS)...
  61. ncbi Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures
    Joseph O Humtsoe
    Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Cell Biol 30:1593-606. 2010
    ..Thus, our study identified a key role for LPP3 in orchestrating PTEN-mediated beta-catenin/LEF-1 signaling in EC migration, cell-cell adhesion, and formation of branching point structures...
  62. ncbi Hot spots in beta-catenin for interactions with LEF-1, conductin and APC
    J P von Kries
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13093 Berlin, Germany
    Nat Struct Biol 7:800-7. 2000
    ..These residues form separate surface clusters, termed hot spots, along the armadillo superhelix of beta-catenin...
  63. ncbi Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation
    L Geng
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, Box 1243, 1 Gustave L Levy Place, 10029, New York, NY 10029, USA
    Biochim Biophys Acta 1535:21-35. 2000
    ..Although inhibition of tyrosine phosphorylation by tyrphostin inhibits polycystin-1-FAK interactions, E-cadherin interactions are enhanced. High calcium treatment also increases polycystin-1-E-cadherin interactions...
  64. ncbi Identification of beta-catenin as a novel substrate of Polo-like kinase 1
    Tsuyoshi Arai
    Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Tsukuba, Ibaraki, Japan
    Cell Cycle 7:3556-63. 2008
    ..These results demonstrate that beta-catenin is a physiological substrate of Plk1 in cells, which may provide a novel insight into the role of beta-catenin in M phase...
  65. ncbi Negative regulation of beta-catenin signaling by tyrosine phosphatase SHP-1 in intestinal epithelial cells
    Cathia Duchesne
    Département d Anatomie et Biologie Cellulaire, Faculte de Medecine, Universite de Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 278:14274-83. 2003
    ..Taken together, our results indicate that SHP-1 may be involved in the regulation of beta-catenin transcriptional function and in the negative control of intestinal epithelial cell proliferation...
  66. ncbi Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad
    Hirofumi Mizusaki
    Department of Developmental Biology, National Institute for Basic Biology, Myodaiji cho, Okazaki 444 8585, Japan
    Mol Endocrinol 17:507-19. 2003
    ..We thus conclude that Wnt4 signaling mediates the increased expression of Dax-1 as the ovary becomes sexually differentiated...
  67. ncbi Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6
    Helena L Palka-Hamblin
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    J Cell Sci 123:236-45. 2010
    ..The ability of PTK6 to negatively regulate beta-catenin/TCF transcription by modulating levels of TCF4 and TLE/Groucho could contribute to its growth-inhibitory activities in vivo...
  68. ncbi Positive inter-regulation between beta-catenin/T cell factor-4 signaling and endothelin-1 signaling potentiates proliferation and survival of prostate cancer cells
    Ping Sun
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Mol Pharmacol 69:520-31. 2006
    ..The positive inter-regulation between beta-cat/Tcf-4 signaling and ET-1 signaling potentiates proliferation and survival of CaP cells, thereby representing a novel mechanism that contributes to CaP progression...
  69. ncbi The EWS/FLI1 oncogenic protein inhibits expression of the Wnt inhibitor DICKKOPF-1 gene and antagonizes beta-catenin/TCF-mediated transcription
    Diego Navarro
    Departamento de Biología del Cáncer, Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Arturo Duperier 4, E 28029, Madrid, Spain
    Carcinogenesis 31:394-401. 2010
    ..Our results show that EWS/FLI1 inhibits both DKK-1 expression as well as beta-catenin/TCF-dependent transcription, which could contribute to progression of tumours of the Ewing family...
  70. ncbi A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells
    Jong In Yook
    Department of Oral Pathology, Oral Cancer Research Institute, College of Dentistry Yonsei University, Seoul 120 752, Korea
    Nat Cell Biol 8:1398-406. 2006
    ..As dysregulated Wnt signalling marks a diverse array of cancerous tissue types, the identification of a beta-catenin-TCF-regulated Axin2-GSK3beta-Snail1 axis provides new mechanistic insights into cancer-associated EMT programmes...
  71. ncbi Functional interaction between beta-catenin and FOXO in oxidative stress signaling
    Marieke A G Essers
    Department of Physiological Chemistry and Center for Biomedical Genetics, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, Netherlands
    Science 308:1181-4. 2005
    ..These results demonstrate a role for beta-catenin in regulating FOXO function that is particularly important under conditions of oxidative stress...
  72. ncbi RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis
    Kosei Ito
    Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673
    Cancer Cell 14:226-37. 2008
    ..Taken together, these data demonstrate that RUNX3 functions as a tumor suppressor by attenuating Wnt signaling...
  73. ncbi The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin
    A H Huber
    Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 105:391-402. 2001
    ..APC contains sequences homologous to the phosphorylated region of cadherin, and is likely to bind similarly...
  74. ncbi Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071
    B Stahl
    Max Planck Institute for Experimental Medicine, 37075 Gottingen, Germany
    J Biol Chem 274:9141-8. 1999
    ..We utilized the yeast two-hybrid system to identify an interacting armadillo protein, termed p0071, that binds specifically to the hydrophilic loop of presenilin 1...
  75. ncbi The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade
    Cristina Albuquerque
    Centro de Investigacao de Patobiologia Molecular CIPM, Instituto Portugues de Oncologia Francisco Gentil, 1093 Lisbon, Portugal
    Hum Mol Genet 11:1549-60. 2002
    ..We propose that this selection process is aimed at a specific degree of beta-catenin signaling optimal for tumor formation, rather than at its constitutive activation by deletion of all of the beta-catenin downregulating motifs in APC...
  76. ncbi Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study
    Margreet Lüchtenborg
    Nutrition and Toxicology Research Institute Maastricht, Department of Epidemiology, Maastricht University, Maastricht, The Netherlands
    BMC Cancer 5:160. 2005
    ..A smaller proportion of cancers shows mismatch repair deficiency. The aim of this study was to analyse the co-occurrence of these genetic alterations in relation to tumour and patient characteristics...
  77. ncbi Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways
    E Labbe
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, M5S 1A8
    Proc Natl Acad Sci U S A 97:8358-63. 2000
    ..Thus, our results show that TGFbeta and Wnt signaling pathways can independently or cooperatively regulate LEF1/TCF target genes and suggest a model for how these pathways can synergistically activate target genes...
  78. ncbi Mutations in exon 3 of the beta-catenin gene are rare in melanoma cell lines
    P M Pollock
    Joint Experimental Oncology Program of the Queensland Institute of Medical Research, The University of Queensland, and the Queensland Cancer Fund, P O Royal Brisbane Hospital, Herston 4029, Australia
    Melanoma Res 12:183-6. 2002
    ..One out of 62 (1.6%) cell lines was found to carry a mutation, indicating that aberration of the Wnt-1/wingless pathway through activation of beta-catenin is a rare event, even in melanoma cell lines...
  79. ncbi A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells
    Zhongyu Liu
    Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    J Biol Chem 281:17156-63. 2006
    ..These results identify a potential mechanism whereby BMP-2 antagonizes Wnt signaling in osteoblast progenitors by promoting an interaction between Smad1 and Dvl-1 that restricts beta-catenin activation...
  80. ncbi Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription
    E T Strovel
    Division of Human Genetics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 275:2399-403. 2000
    ..PP2C utilizes Axin as a substrate both in vitro and in vivo and decreases its half-life. These results indicate that PP2C is a positive regulator of Wnt signal transduction and mediates its effects through the dephosphorylation of Axin...
  81. ncbi Association of human protein-tyrosine phosphatase kappa with members of the armadillo family
    M Fuchs
    Department of Molecular Biology, Max Planck Institut fur Biochemie, Am Klopferspitz 18a, 82152 Martinsried, Federal Republic of Germany
    J Biol Chem 271:16712-9. 1996
    ....
  82. ncbi The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation
    N Barker
    Department of Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    EMBO J 20:4935-43. 2001
    ..We conclude that beta-catenin recruits Brg-1 to Tcf target gene promoters, facilitating chromatin remodelling as a prerequisite for transcriptional activation...
  83. ncbi Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level
    T Nakamura
    Department of Oncogene Research, Institute for Microbial Diseases, Osaka University, Suita, Japan
    Genes Cells 3:395-403. 1998
    ..The Wnt/Wingless signalling pathway plays an important role in both embryonic development and tumorigenesis. Beta-catenin and Axin are positive and negative effectors of the Wnt signalling pathway, respectively...
  84. ncbi Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex
    L Baki
    Department of Psychiatry, Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 98:2381-6. 2001
    ..These data identify PS1 as an E-cadherin-binding protein and a regulator of E-cadherin function in vivo...
  85. ncbi Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein
    K Tago
    Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo ku, Tokyo 113, Japan
    Genes Dev 14:1741-9. 2000
    ..These results suggest that ICAT negatively regulates Wnt signaling via inhibition of the interaction between beta-catenin and TCF and is integral in development and cell proliferation...
  86. ncbi Dickkopf-1 enhances migration of HEK293 cell by beta-catenin/E-cadherin degradation
    Hai Bin Kuang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P R China
    Front Biosci 14:2212-20. 2009
    ..Together, our data suggest that Dkk-1 stimulates the release of beta-catenin from cell membrane and facilitates cell migration which accompanies degradation of beta-catenin/E-cadherin...
  87. ncbi Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein
    A Bauer
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
    Proc Natl Acad Sci U S A 95:14787-92. 1998
    beta-catenin, the vertebrate homolog of the Drosophila Armadillo protein, has been shown to have dual cellular functions, as a component of both the cadherin-catenin cell adhesion complex and the Wnt signaling pathway...
  88. ncbi Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis
    B M McCartney
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    J Cell Biol 146:1303-18. 1999
    ..Wg)/Wnt signal transduction by helping target the Wnt effector beta-catenin or its Drosophila homologue Armadillo (Arm) for destruction...
  89. ncbi A common human skin tumour is caused by activating mutations in beta-catenin
    E F Chan
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, Illinois 60637, USA
    Nat Genet 21:410-3. 1999
    ..This percentage of CTNNB1 mutations is greater than in all other human tumours examined thus far, and directly implicates beta-catenin/LEF misregulation as the major cause of hair matrix cell tumorigenesis in humans...
  90. ncbi Beta-catenin overexpression augments angiogenesis and skeletal muscle regeneration through dual mechanism of vascular endothelial growth factor-mediated endothelial cell proliferation and progenitor cell mobilization
    Kwang Il Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Korea
    Arterioscler Thromb Vasc Biol 26:91-8. 2006
    ..However, little is known regarding its role in endothelial cell (EC) and skeletal muscle proliferation and progenitor cell mobilization...
  91. ncbi Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling
    Tohru Ishitani
    Department of Molecular Biology, Graduate School of Science, Nagoya University, and CREST, Japan Science and Technology Corporation, Chikusa ku, Nagoya 464 8602, Japan
    Mol Cell Biol 23:1379-89. 2003
    ..These results suggest that NLK phosphorylation on these sites contributes to the down-regulation of LEF-1/TCF transcriptional activity...
  92. ncbi G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the {beta}-catenin pathway
    Ming Yang
    Department of Biology, Amgen, Inc, 1120 Veterans Boulevard, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 102:6027-32. 2005
    ..Thus, LPA(2) and LPA(3) signal the proliferation of colon cancer cells through cPKC-mediated activation of the beta-catenin pathway. These results link LPA and its GPCRs to cancer through a major oncogenic signaling pathway...
  93. ncbi Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy
    Brian K Jordan
    Department of Human Genetics, University of California School of Medicine, Los Angeles, CA 90095 7088, USA
    Proc Natl Acad Sci U S A 100:10866-71. 2003
    ..Our findings suggest a model in which Wnt4 acts as an anti-male factor by disrupting recruitment of beta-catenin at or near steroidogenic factor 1 binding sites present in multiple steroidogenic genes...
  94. ncbi Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells
    Sanita Bharti
    Humangenetik fuer Biologen, Johann Wolfgang Goethe Universitat, D 60054 Frankfurt, Germany
    Mol Biol Cell 15:397-406. 2004
    ..In summary, we introduce shrew-1 as a novel component of adherens junctions, interacting with E-cadherin-beta-catenin complexes in polarized epithelial cells...
  95. ncbi Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin
    Shin Ichiro Hino
    Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3, Kasumi, Minami Ku, Japan
    J Biol Chem 278:14066-73. 2003
    ..These results indicate that CKI epsilon-dependent phosphorylation of Dvl enhances the formation of a complex of Dvl-1 with Frat-1 and that this complex leads to the activation of the Wnt signaling pathway...
  96. ncbi The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells
    Mutsumi Kanamori
    Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
    J Biol Chem 278:38758-64. 2003
    ..These data suggest that TIP-1 may represent a novel regulatory element in the Wnt/beta-catenin signaling pathway...
  97. ncbi T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors
    Jennifer A Kennell
    Program in Cellular and Molecular Biology, Division of Endocrinology and Metabolism, University of Michigan Medical School, 1301 E Catherine Road, Ann Arbor, MI 48109 0622, USA
    Mol Cell Biol 23:5366-75. 2003
    ..Thus, we propose that TCF-4N inhibits coactivation by beta-catenin of TCF/LEF transcription factors and potentiates the coactivation by beta-catenin of other transcription factors, such as SF-1 and C/EBPalpha...
  98. ncbi Increased cyclin D1 expression in cancer of the ampulla of Vater: relevance to nuclear beta catenin accumulation and k-ras gene mutation
    K Yamazaki
    Department of Pathology, Teikyo University, Ichihara Hospital, Ichihara, 299 0111, Japan
    Mol Pathol 56:336-41. 2003
    Several studies have reported that dysregulation of beta catenin or k-ras mutation promotes cyclin D1 expression...
  99. ncbi The ZW sex microchromosomes of an Australian dragon lizard share no homology with those of other reptiles or birds
    Tariq Ezaz
    Institute for Applied Ecology, University of Canberra, Canberra, Australia
    Chromosome Res 17:965-73. 2009
    ..hokouensis ZW chromosomes pairs is coincidental, may be an example of convergent evolution, its status as the Z chromosome having been independently derived in birds and G. hokouensis...
  100. ncbi Non-homologous sex chromosomes of birds and snakes share repetitive sequences
    Denis O'Meally
    Research School of Biology, Australian National University, Acton, ACT 0200, Australia
    Chromosome Res 18:787-800. 2010
    ..We also establish that synteny of snake Z-linked genes has been conserved for at least 166 million years and that the snake Z consists of two conserved blocks derived from the same ancestral vertebrate chromosome...
  101. ncbi Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses LH-mediated ovulation and luteinization
    Heng Yu Fan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 24:1529-42. 2010
    ....

Research Grants90

  1. Role of Ectodermal Signals in Facial Prominence Outgrowth and Development
    Trevor J Williams; Fiscal Year: 2010
    ....
  2. MSX2-Wnt Signaling in Cardiovascular Calcification
    Dwight A Towler; Fiscal Year: 2010
    ..We test whether regulation of these proteins reduces arterial hardening, decreases cardiac workload, and improves blood flow to the foot. ..
  3. BETA-CATENIN AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CANCER
    SATDARSHAN MONGA; Fiscal Year: 2007
    ..Thus this proposal will lay the ground work for initiating clinical studies directed against ¿-catenin in HCC. ..
  4. BETA-CATENIN AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CANCER
    SATDARSHAN MONGA; Fiscal Year: 2009
    ..Thus this proposal will lay the ground work for initiating clinical studies directed against -catenin in HCC. ..
  5. BETA-CATENIN AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CANCER
    SATDARSHAN SINGH MONGA; Fiscal Year: 2010
    ..Thus this proposal will lay the ground work for initiating clinical studies directed against -catenin in HCC. ..
  6. WT1 and beta-catenin targets in Wilms tumor
    Benjamin Tycko; Fiscal Year: 2007
    ..other phosphorylation sites in affecting the proliferative/oncogenic potency of beta-catenin. We will subsequently cross these mice with Wt1-mutant heterozygotes, possibly generating a mouse model for Wilms tumor. ..
  7. Molecular Pathogenesis of Ovarian Endometrioid Adenocarcinomas
    KATHLEEN CHO; Fiscal Year: 2009
    ....
  8. Molecular Pathogenesis of Ovarian Endometrioid Adenocarc
    KATHLEEN CHO; Fiscal Year: 2006
    ..abstract_text> ..
  9. Molecular Pathogenesis of Ovarian Endometrioid Adenocarcinomas
    KATHLEEN CHO; Fiscal Year: 2007
    ....
  10. Molecular Pathogenesis of Ovarian Endometrioid Adenocarcinomas
    Kathleen R Cho; Fiscal Year: 2010
    ....
  11. Deciphering Beta-Catenin Contributions in Prostate Cance
    David Mulholland; Fiscal Year: 2007
    ..These cells will be assessed for growth and PSA secretion in tumours carried as xenografts. These novel in vivo tools will allow understanding to the role of Beta-catenin has in Al PrCa. ..
  12. Epigenetic Events and Colorectal Cancer Epidemiology
    Shuji Ogino; Fiscal Year: 2010
    ..Through better understanding of epigenetic mechanisms of colorectal cancer development and progression, we can provide a scientific basis for dietary recommendations and help optimize preventive strategies. ..
  13. MOLECULAR EPIDEMIOLOGY OF COLORECTAL CANCER
    Shuji Ogino; Fiscal Year: 2007
    ..Charles Fuchs, a well-established researcher in clinical oncology and epidemiology. At the completion of the projects, I will have gained the experience to become an independent researcher in cancer epidemiology. ..
  14. Novel Therapeutic Strategies for PKD
    Patricia Wilson; Fiscal Year: 2007
    ..abstract_text> ..
  15. Role of Wnt/Frizzled signaling during eye development
    Sabine Fuhrmann; Fiscal Year: 2007
    ..We will use a reporter of Wnt/beta catenin signaling in transgenic Xenopus and mouse embryos to define when and where during eye development this ..
  16. Role of Fibroblasts in Cancer
    Raghu Kalluri; Fiscal Year: 2010
    ..The role of such fibroblasts in cancer progression and metastasis is unknown. This proposal addresses the role of fibroblasts in facilitating metastasis. ..
  17. Role for Wnt/beta-catenin signaling in alveolar repair and fibrosis
    Cara J Gottardi; Fiscal Year: 2011
    ..Thus, new insights into the mechanisms of pulmonary fibrosis are needed to generate novel therapeutic treatments. ..
  18. Epigenetic changes and phenotype-specific therapeutic strategies in breast cancer
    Stefanie S Jeffrey; Fiscal Year: 2010
    ..This proposal should demonstrate how tumor biology and genomic signatures can be translated into strategies for personalized cancer treatment. ..
  19. mTOR Signaling Pathways
    Thomas W Sturgill; Fiscal Year: 2010
    ..We will investigate novel candidate mTOR-interacting proteins identified by MS. Finally, to understand better the mechanisms involved in mTORC2, we propose to identify pianissimo-interacting proteins. ..
  20. Role of Fibroblasts in Cancer
    Raghu Kalluri; Fiscal Year: 2009
    ..The role of such fibroblasts in cancer progression and metastasis is unknown. This proposal addresses the role of fibroblasts in facilitating metastasis. ..
  21. Role of Fibroblasts in Cancer
    Raghu Kalluri; Fiscal Year: 2010
    ..The role of such fibroblasts in cancer progression and metastasis is unknown. This proposal addresses the role of fibroblasts in facilitating metastasis. ..
  22. ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE
    Raghu Kalluri; Fiscal Year: 2001
    ..Successful completion of this project should provide new experimental information regarding the processes that govern the pathogenesis of human anti-GBM disease. ..
  23. mTOR Signaling Pathways
    Thomas Sturgill; Fiscal Year: 2009
    ..We will investigate novel candidate mTOR-interacting proteins identified by MS. Finally, to understand better the mechanisms involved in mTORC2, we propose to identify pianissimo-interacting proteins. ..
  24. Regulation and Function of MAPKAP Kinases
    Thomas Sturgill; Fiscal Year: 2005
    ..Aim four is to characterize the activation, enzymatic properties, and functions of MAPKAP kinase-like enzymes (Rcklp, Rck2p) in yeast, a model eukaryote, using combined biochemical and genetic approaches. ..
  25. Mechanism of b-catenin targeting to adhesive or transcriptional complexes
    CARA GOTTARDI; Fiscal Year: 2007
    ....
  26. The Biology and Function of BMP-7 in the Kidney
    Raghu Kalluri; Fiscal Year: 2007
    ..The physiological role of BMP-7 in kidney health and pathology will be established. These studies will directly benefit the development of this molecule in the clinic as a drug for patients with kidney fibrosis. ..
  27. Mice That Lack CDO: A Model for Mild Holoprosencephaly
    ROBERT KRAUSS; Fiscal Year: 2004
    ....
  28. Role of Plakophilin-1 in HNSCC
    James Wahl; Fiscal Year: 2007
    ..Plakophilin-1 is a member of the Armadillo (Arm) protein family that is a structural component of the cell-cell adhesion junction known as the desmosome...
  29. THE ROLE OF CDO IN MYOGENIC DIFFERENTIATION
    ROBERT KRAUSS; Fiscal Year: 2009
    ..This research should shed light on fundamental processes by which skeletal muscles develop and therefore advance potential strategies for improved treatment of skeletal muscle diseases. ..
  30. Gene-Environment Interaction in Holoprosencephaly: Role of Fetal Alcohol Exposure
    ROBERT KRAUSS; Fiscal Year: 2007
    ..Such information may have important public health impact and could ultimately aid in the counseling of HPE mutation carriers. ..
  31. APC PATHWAY--A TARGET FOR CHEMOPREVENTIVE INTERVENTION
    Wen Chi Chang; Fiscal Year: 2005
    ..in nutritional biochemistry when combined with the proposed training in cancer prevention and molecular genetics will provide her with the unique ability to develop both natural and synthetic compounds as clinical chemopreventive agents ..
  32. Molecular Function of the Nf2 Tumor Suppressor, Merlin
    Andrea McClatchey; Fiscal Year: 2009
    ..The results of this study will yield important insight into the mechanism of Merlin function as a tumor suppressor and identify novel targets for therapeutic intervention of NF2. ..
  33. Matrix Microenvironment and Liver Fibrosis
    Raghu Kalluri; Fiscal Year: 2007
    ..Therefore, this application is well poised to identify a unique mechanism of liver fibrosis and also study a therapeutic agent, which works against this mechanism and inhibits progression of liver disease. ..
  34. Role of Plakophilin-1 in HNSCC
    James Wahl; Fiscal Year: 2006
    ..Plakophilin-1 is a member of the Armadillo (Arm) protein family that is a structural component of the cell-cell adhesion junction known as the desmosome...
  35. Assembly of type IV collagen in health and disease
    Raghu Kalluri; Fiscal Year: 2009
    ..We expect this grant application to provide basic understanding of the assembly and function of type IV collagen in the GBM. ..
  36. Role of Plakophilin-1 in HNSCC
    James Wahl; Fiscal Year: 2009
    ..Plakophilin-1 is a member of the Armadillo (Arm) protein family that is a structural component of the cell-cell adhesion junction known as the desmosome...
  37. Regulation of Angiogenesis by Tumstatin
    Raghu Kalluri; Fiscal Year: 2006
    ..abstract_text> ..
  38. Early Events in Colitis-Associated Colorectal Cancer
    Wen Chi Chang; Fiscal Year: 2003
    ..abstract_text> ..