beta-catenin

Summary

Gene Symbol: beta-catenin
Description: catenin (cadherin-associated protein), beta 1, 88kDa
Alias: CTNNB, MRD19, armadillo, catenin beta-1
Species: human

Top Publications

  1. pmc Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
    Yingwei Mao
    Howard Hughes Medical Institute, Cambridge, MA 02139, USA
    Cell 136:1017-31. 2009
  2. ncbi Functional interaction of beta-catenin with the transcription factor LEF-1
    J Behrens
    Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    Nature 382:638-42. 1996
  3. ncbi Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    P J Morin
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 275:1787-90. 1997
  4. ncbi Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    V Korinek
    Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
    Science 275:1784-7. 1997
  5. ncbi Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion
    Zhimin Lu
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cancer Cell 4:499-515. 2003
  6. pmc MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1
    Mohit Sachdeva
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    Cancer Res 70:378-87. 2010
  7. ncbi Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    Chunming Liu
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell 108:837-47. 2002
  8. pmc Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model
    Andy J Chien
    Institute for Stem Cell and Regenerative Medicine, Department of Medicine, Division of Dermatology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 106:1193-8. 2009
  9. ncbi Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase
    Sebastien Taurin
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Biol Chem 281:9971-6. 2006
  10. ncbi P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin
    Liuqing Yang
    Department of Biology, Georgia State University, University Plaza, Atlanta, GA 30303, USA
    Cell 127:139-55. 2006

Detail Information

Publications269 found, 100 shown here

  1. pmc Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
    Yingwei Mao
    Howard Hughes Medical Institute, Cambridge, MA 02139, USA
    Cell 136:1017-31. 2009
    ..Together, these results implicate DISC1 in GSK3beta/beta-catenin signaling pathways and provide a framework for understanding how alterations in this pathway may contribute to the etiology of psychiatric disorders...
  2. ncbi Functional interaction of beta-catenin with the transcription factor LEF-1
    J Behrens
    Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    Nature 382:638-42. 1996
    The cytoplasmic proteins beta-catenin of vertebrates and armadillo of Drosophila have two functions: they link the cadherin cell-adhesion molecules to the cytoskeleton, and they participate in the wnt/wingless signal pathway...
  3. ncbi Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    P J Morin
    Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 275:1787-90. 1997
    ..These results indicate that regulation of beta-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or beta-catenin...
  4. ncbi Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    V Korinek
    Department of Immunology, University Hospital, Post Office Box 85500, 3508 GA Utrecht, Netherlands
    Science 275:1784-7. 1997
    ..Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium...
  5. ncbi Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion
    Zhimin Lu
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cancer Cell 4:499-515. 2003
    ..We propose that EGF-induced negative regulation of caveolin-1 plays a central role in the complex cellular changes leading to metastasis...
  6. pmc MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1
    Mohit Sachdeva
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794, USA
    Cancer Res 70:378-87. 2010
    ..Taken together, these results suggest that as a tumor suppressor, miR-145 inhibits not only tumor growth but also cell invasion and metastasis...
  7. ncbi Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    Chunming Liu
    Division of Neuroscience, Children s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Cell 108:837-47. 2002
    ..Our study uncovers distinct roles and steps of beta-catenin phosphorylation, identifies CKIalpha as a component in Wnt/beta-catenin signaling, and has implications to pathogenesis/therapeutics of human cancers and diabetes...
  8. pmc Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model
    Andy J Chien
    Institute for Stem Cell and Regenerative Medicine, Department of Medicine, Division of Dermatology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 106:1193-8. 2009
    ..Our results may explain the observed loss of nuclear beta-catenin with melanoma progression in human tumors, which could reflect a dysregulation of cellular differentiation through a loss of homeostatic Wnt/beta-catenin signaling...
  9. ncbi Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase
    Sebastien Taurin
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    J Biol Chem 281:9971-6. 2006
    ..In conclusion, this study identifies a novel, noncanonical mechanism of modulation of beta-catenin signaling through direct phosphorylation of beta-catenin by PKA, promoting its interaction with CREB-binding protein...
  10. ncbi P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin
    Liuqing Yang
    Department of Biology, Georgia State University, University Plaza, Atlanta, GA 30303, USA
    Cell 127:139-55. 2006
    ..These data demonstrated a novel mechanism of phosphor-p68 in mediating the growth factor-induced EMT and uncovered a new pathway to promote beta-catenin nuclear translocation...
  11. ncbi Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses
    S I Matsuzawa
    The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell 7:915-26. 2001
    ..Expression of Siah is induced by p53, revealing a way of linking genotoxic injury to destruction of beta-catenin, thus reducing activity of Tcf/LEF transcription factors and contributing to cell cycle arrest...
  12. ncbi Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer
    Ann Mårtensson
    Department of Medical Biosciences, Pathology, Umea University, SE 901 85 Umea, Sweden
    Oncol Rep 17:447-52. 2007
    ..01). Our results suggest that nuclear accumulation of beta-catenin in CRC is related to CIN and may be of prognostic importance. However, larger studies are needed to verify these findings...
  13. pmc Requirement of cell cycle and apoptosis regulator 1 for target gene activation by Wnt and beta-catenin and for anchorage-independent growth of human colon carcinoma cells
    Chen Yin Ou
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 284:20629-37. 2009
    ....
  14. ncbi Association of the APC tumor suppressor protein with catenins
    L K Su
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231
    Science 262:1734-7. 1993
    ..A 27-residue fragment of APC containing a 15-amino acid repeat was sufficient for the interaction with the catenins. These results suggest an important link between tumor initiation and cell adhesion...
  15. ncbi Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover
    B R Henderson
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millenium Institute, Westmead NSW 2145, Australia
    Nat Cell Biol 2:653-60. 2000
    ..These findings suggest that wild-type APC controls the nuclear accumulation of beta-catenin by a combination of nuclear export and cytoplasmic degradation...
  16. ncbi Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
    Michael B Major
    Howard Hughes Medical Institute, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA
    Science 316:1043-6. 2007
    ..These data provide a possible mechanistic explanation for the tumor suppressor activity of WTX...
  17. pmc Beta-catenin mutations in cell lines established from human colorectal cancers
    M Ilyas
    Cancer Genetics and Immunology Laboratory, Imperial Cancer Research Fund, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 94:10330-4. 1997
    ....
  18. ncbi MUC1 and nuclear beta-catenin are coexpressed at the invasion front of colorectal carcinomas and are both correlated with tumor prognosis
    Stephan E Baldus
    Institute of Pathology, University of Cologne, Cologne, Germany
    Clin Cancer Res 10:2790-6. 2004
    ..We tried to elucidate the coexpression of both molecules in colorectal cancer to demonstrate possible correlations with clinical, pathological, and prognostic data...
  19. doi Transcriptome analysis reveals that p53 and {beta}-catenin alterations occur in a group of aggressive adrenocortical cancers
    Bruno Ragazzon
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, INSERM, U1016, Paris, France
    Cancer Res 70:8276-81. 2010
    ..This study shows the important respective roles of p53 and β-catenin in ACC development, delineating subgroups of ACC with different tumorigenesis and outcomes...
  20. doi Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors
    Sebastien Gaujoux
    Service des Maladies Endocriniennes et Metaboliques, Hopital Cochin, 75014 Paris, France
    J Clin Endocrinol Metab 93:4135-40. 2008
    ..PRKAR1A mutations leading to cAMP pathway dysregulation are observed in primary pigmented nodular adrenocortical diseases (PPNADs) and some sporadic ACAs...
  21. ncbi CTNNB1 mutations and beta-catenin expression in endometrial carcinomas
    Pilar Machin
    Department of Pathology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Hum Pathol 33:206-12. 2002
    Mutations in the beta-catenin gene (CTNNB 1) with abnormal nuclear accumulation of beta-catenin have recently been identified in endometrial carcinoma (EC). Their relationship with microsatellite instability (MI) is unclear...
  22. ncbi Pax3 functions at a nodal point in melanocyte stem cell differentiation
    Deborah Lang
    Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 433:884-7. 2005
    ..Thus, a stem cell transcription factor can both determine cell fate and simultaneously maintain an undifferentiated state, leaving a cell poised to differentiate in response to external stimuli...
  23. pmc Nuclear beta-catenin induces an early liver progenitor phenotype in hepatocellular carcinoma and promotes tumor recurrence
    Gudrun Zulehner
    Department of Internal Medicine I, Centre of Public Health, Medical University of Vienna, Vienna, Austria
    Am J Pathol 176:472-81. 2010
    ..These data suggest that activation of beta-catenin signaling causes dedifferentiation to malignant, immature hepatocyte progenitors and facilitates recurrence of human HCC after orthotopic liver transplantation...
  24. ncbi Diagnostic and prognostic impact of beta-catenin alterations in pediatric liver tumors
    Hiroaki Yamaoka
    Department of Surgery, Hiroshima University, Hiroshima, Japan
    Oncol Rep 15:551-6. 2006
    ..On the other hand, the expression of cyclin D1, a gene downstream of beta-catenin, might play a role in tumor progression...
  25. ncbi Beta-catenin is involved in insulin-like growth factor 1-mediated transactivation of the androgen receptor
    Meletios Verras
    Department of Urology, R135, Edwards Building, Stanford University School of Medicine, Stanford, California 94305 5328, USA
    Mol Endocrinol 19:391-8. 2005
    ..Moreover, using a pulse-chase experiment, we showed that IGF-I enhances the stability of beta-catenin in prostate cancer cells. Our findings delineate a novel pathway for IGF-I in modulating androgen signaling through beta-catenin...
  26. pmc E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
    J Hülsken
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Cell Biol 127:2061-9. 1994
    ..E-cadherin and also with the tumor suppressor gene product APC, and the Drosophila homologue of beta-catenin, armadillo, mediates morphogenetic signals...
  27. ncbi Crystal structure of a beta-catenin/Tcf complex
    T A Graham
    Department of Biological Structure University of Washington 98195, Seattle, WA, USA
    Cell 103:885-96. 2000
    ..three binding modules that runs antiparallel to beta-catenin along the positively charged groove formed by the armadillo repeats...
  28. doi Activation of beta-catenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis
    Liang Liu
    Department of Hepatobiliary and Pancreatic Surgery, Fudan University Cancer Hospital, Fudan University, Shanghai, PR China
    Clin Cancer Res 16:2740-50. 2010
    ..However, the association between beta-catenin and the proinvasive role of hypoxia remains unclear. We investigated the role of beta-catenin in the proinvasive consequences of hypoxia in HCC...
  29. pmc Wnt-5a-CKI{alpha} signaling promotes {beta}-catenin/E-cadherin complex formation and intercellular adhesion in human breast epithelial cells
    Catharina Medrek
    Cell and Experimental Pathology and Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Universitetssjukhuset Malmö Allmänna Sjukhus, 20502 Malmo, Sweden
    J Biol Chem 284:10968-79. 2009
    ....
  30. ncbi Assembly of the cadherin-catenin complex in vitro with recombinant proteins
    H Aberle
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    J Cell Sci 107:3655-63. 1994
    ..The reconstitution in vitro of the cadherin-catenin complex should allow the study of the interaction with signalling molecules and with the actin-based cytoskeleton...
  31. ncbi Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia
    Abderrahmane Kaidi
    Cancer Research UK Colorectal Tumour Biology Research Group, Department of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK
    Nat Cell Biol 9:210-7. 2007
    ..This study highlights the importance of the microenvironment in transcriptional regulation...
  32. pmc Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor
    Hans R Widlund
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Dana 630, 44 Binney Street, Boston, MA 02115, USA
    J Cell Biol 158:1079-87. 2002
    ..Thus, beta-catenin regulation of MITF expression represents a tissue-restricted pathway that significantly influences the growth and survival behavior of this notoriously treatment-resistant neoplasm...
  33. pmc Wnt/beta-catenin pathway activation is enriched in basal-like breast cancers and predicts poor outcome
    Andrey I Khramtsov
    University of Chicago, Department of Medicine, Chicago, IL 60637, USA
    Am J Pathol 176:2911-20. 2010
    ....
  34. ncbi The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin
    S Taya
    Division of Signal Transduction, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 0101, Japan
    Genes Cells 4:757-67. 1999
    ..These observations prompted us to examine the possible Fam regulation of the stabilization of beta-catenin...
  35. ncbi Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
    M J Hart
    Onyx Pharmaceuticals, Richmond, California 94806, USA
    Curr Biol 8:573-81. 1998
    ..This suggests a possible link between Axin, the Wnt-1 signaling components beta-catenin and glycogen synthase kinase 3 beta (GSK3 beta), and APC...
  36. pmc Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction
    Laurence Levy
    Unité d Oncogenèse et Virologie Moléculaire INSERM U579, Institut Pasteur, 75015 Paris, France
    Mol Cell Biol 24:3404-14. 2004
    ..Thus, our results describe a new mechanism by which p300 might regulate beta-catenin transcriptional activity...
  37. ncbi Prognostic and diagnostic significance of beta-catenin nuclear immunostaining in colorectal cancer
    Sze Chuen Cesar Wong
    Biomedical Science, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
    Clin Cancer Res 10:1401-8. 2004
    ..Collectively, the present large-scale study has clearly addressed the clinical significance of beta-catenin nuclear translocation with respect to tumor progression, survival, and differential diagnosis...
  38. doi The intratumoral distribution of nuclear beta-catenin is a prognostic marker in colon cancer
    David Horst
    Pathologisches Institut der Ludwig Maximilians Universität, Munich, Germany
    Cancer 115:2063-70. 2009
    ..Herein, the authors investigated whether the intratumoral distribution of nuclear beta-catenin can serve as a prognostic marker for survival and tumor progression of stage IIA colon cancer patients...
  39. ncbi Adenomatous polyposis coli (APC) differentially regulates beta-catenin phosphorylation and ubiquitination in colon cancer cells
    Jun Yang
    Sealy Center for Cancer Cell Biology and Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Biol Chem 281:17751-7. 2006
    ..The APC domains required for beta-catenin ubiquitination were analyzed. Our results suggest that APC regulates beta-catenin phosphorylation and ubiquitination by distinct domains and by separate molecular mechanisms...
  40. ncbi Deregulated Wnt/beta-catenin program in high-risk neuroblastomas without MYCN amplification
    X Liu
    Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    Oncogene 27:1478-88. 2008
    ..Thus, high-risk NBs without MYCN amplification may deregulate MYC and other oncogenic genes via altered beta-catenin signaling providing a potential candidate pathway for therapeutic inhibition...
  41. ncbi Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad
    Hirofumi Mizusaki
    Department of Developmental Biology, National Institute for Basic Biology, Myodaiji cho, Okazaki 444 8585, Japan
    Mol Endocrinol 17:507-19. 2003
    ..We thus conclude that Wnt4 signaling mediates the increased expression of Dax-1 as the ovary becomes sexually differentiated...
  42. pmc Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors
    Alexander J F Lazar
    Sarcoma Research Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4001, USA
    Am J Pathol 173:1518-27. 2008
    ..In conclusion, CTNNB1 mutations are highly common in desmoid tumors. Furthermore, patients harboring CTNNB1 (45F) mutations are at particular risk for recurrence and therefore may especially benefit from adjuvant therapeutic approaches...
  43. ncbi Frequent mutations of beta-catenin gene in sporadic secreting adrenocortical adenomas
    Mimi Tadjine
    Division of Endocrinology, Department of Medicine, Centre Hospitalier de l Universite de Montreal CHUM, Hotel Dieu, Montreal, Quebec, Canada
    Clin Endocrinol (Oxf) 68:264-70. 2008
    ..To better understand the role of Wnt/beta-catenin signalling in adrenocortical tumours, we performed mutational analysis of the beta-catenin gene...
  44. pmc NHERF links the N-cadherin/catenin complex to the platelet-derived growth factor receptor to modulate the actin cytoskeleton and regulate cell motility
    Christopher S Theisen
    Department of Biochemistry and Molecular Biology, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198 7696, USA
    Mol Biol Cell 18:1220-32. 2007
    ..These studies implicate N-cadherin and beta-catenin in cell migration via PDGF-R-mediated signaling through the scaffolding molecule NHERF...
  45. ncbi Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein
    Sheri L Holmen
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, MI 49503, USA
    Biochem Biophys Res Commun 328:533-9. 2005
    ..We found that Dkk1-Fz5, but not Dkk3-Fz5, potently synergized with LRP6 to activate signaling in a dishevelled-dependent manner...
  46. doi Wnt/β-catenin pathway activation in adrenocortical adenomas is frequently due to somatic CTNNB1-activating mutations, which are associated with larger and nonsecreting tumors: a study in cortisol-secreting and -nonsecreting tumors
    Stephane Bonnet
    Department of Endocrinology, Metabolism, and Cancer, Institut National de la Santé et de la Recherche Médicale Unité 1016, Paris, France
    J Clin Endocrinol Metab 96:E419-26. 2011
    ....
  47. ncbi Beta-catenin affects androgen receptor transcriptional activity and ligand specificity
    C I Truica
    Lombardi Cancer Center, Georgetown University, Washington, DC 20007 2197, USA
    Cancer Res 60:4709-13. 2000
    ..The amount of beta-catenin in complex with AR was increased by androgen. These findings implicate beta-catenin in the regulation of AR function and support a role for beta-catenin mutations in the pathogenesis of prostate cancer...
  48. pmc Nuclear beta-catenin overexpression in metastatic sentinel lymph node is associated with synchronous liver metastasis in colorectal cancer
    Hongxia Cheng
    Department of Pathology, Provincial Hospital affiliated to Shandong University, Jinan 250021, Shandong, People s Republic of China
    Diagn Pathol 6:109. 2011
    ..The purpose of this study is to investigate whether nuclear beta-catenin overexpression in metastatic sentinel lymph node(s) [SLN(s)] is associated with synchronous liver metastasis...
  49. pmc Osteopontin induces beta-catenin signaling through activation of Akt in prostate cancer cells
    Brian W Robertson
    Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA
    Exp Cell Res 316:1-11. 2010
    ..This work describes an important aspect of cancer progression induced by OPN...
  50. pmc LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element
    Daniel Hebenstreit
    Department of Molecular Biology, University of Salzburg, 5020 Salzburg, Austria
    J Biol Chem 283:22490-7. 2008
    ..Furthermore, we found that IL-4 stimulation possesses a negative effect on the expressions of LEF-1 and TCF-1 in primary T cells, suggesting a positive feedback effect of IL-4 on IL4 gene expression...
  51. pmc Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling
    Arthit Chairoungdua
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Cell Biol 190:1079-91. 2010
    ..Thus, exosomal packaging and release of cytosolic proteins can modulate the activity of cellular signaling pathways...
  52. doi Reduced membranous beta-catenin protein expression is associated with metastasis and poor prognosis in squamous cell carcinoma of the esophagus
    Po Kuei Hsu
    Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang Ming University, School of Medicine, Taipei, Taiwan
    J Thorac Cardiovasc Surg 135:1029-35. 2008
    ..The clinical relevance and prognostic significance of the expression of these proteins were also analyzed...
  53. ncbi [Influence of E-cadherin promoter methylation and mutation of beta-catenin on invasion and metastasis of nasopharyngeal carcinoma cells]
    Zhi Li
    Department of Pathology, Sun Yat sen Medical College, Zhong Shan University, Guangzhou 510089, China
    Zhonghua Zhong Liu Za Zhi 25:238-42. 2003
    ..To study the mechanism of invasion and metastasis in early nasopharyngeal carcinoma (NPC) in relation to E-cadherin promoter methylation and mutation in exon 3 of beta-catenin...
  54. doi Low membranous expression of beta-catenin and high mitotic count predict poor prognosis in endometrioid carcinoma of the ovary
    Daniel G Rosen
    Department of Pathology, Baylor College of Medicine, Houston, TX, USA
    Mod Pathol 23:113-22. 2010
    ..Our data suggest that there is a need to define a better grading system for ovarian endometrioid carcinoma. Molecular markers such as beta-catenin and mitotic count could aid in defining this grading system...
  55. pmc Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos
    H Yamamoto
    Department of Biochemistry, Hiroshima University School of Medicine, Japan
    Mol Cell Biol 18:2867-75. 1998
    ..These results indicate that Axil negatively regulates the Wnt signaling pathway by mediating GSK-3beta-dependent phosphorylation of beta-catenin, thereby inhibiting axis formation...
  56. doi Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth
    Ninib Baryawno
    Childhood Cancer Research Unit, Department of Women s and Children s Health, Karolinska Institutet, Stockholm, Sweden
    Cancer Res 70:266-76. 2010
    ..These findings demonstrate the importance of cross-talk between the PI3K/Akt and beta-catenin pathways in medulloblastoma and rationalize the PI3K/Akt signaling pathway as a therapeutic target in treatment of this disease...
  57. ncbi Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin
    H Nakagawa
    Department of Genetics, Osaka University Medical School, Suita City, Japan
    Cancer Res 58:5176-81. 1998
    ..These results suggest that the APCL protein may be involved in the Wnt/Wingless signal pathway, and the identification of a novel relative of APC may provide new insights into the function of APC...
  58. pmc Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1
    Yoana N Dimitrova
    Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 285:13507-16. 2010
    ..Siah-1 and TBL1 were found to bind to the same armadillo repeat domain of beta-catenin, suggesting that polyubiquitination of beta-catenin is regulated by competition ..
  59. pmc Nuclear beta-catenin expression as a prognostic factor in advanced colorectal carcinoma
    Adam Elzagheid
    Department of Pathology, University of Turku, Kiinamyllynkatu 10, FIN 20520, Turku, Finland
    World J Gastroenterol 14:3866-71. 2008
    ..To investigate the changing pattern of beta-catenin expression and its prognostic value in advanced colorectal cancer (CRC)...
  60. doi Nonstructural 5A protein activates beta-catenin signaling cascades: implication of hepatitis C virus-induced liver pathogenesis
    Chul Yong Park
    National Research Laboratory of Hepatitis C Virus and Ilsong Institute of Life Science, Hallym University, Dongan Gu, Anyang, Republic of Korea
    J Hepatol 51:853-64. 2009
    ..Wnt/beta-catenin signaling has also been involved in tumorigenesis. To elucidate the molecular mechanism of HCV pathogenesis, we examined the potential effects of HCV NS5A protein on Wnt/beta-catenin signal transduction cascades...
  61. doi Kaiso is a bimodal modulator for Wnt/beta-catenin signaling
    Hidekazu Iioka
    BRB 723, Department of Genetics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    FEBS Lett 583:627-32. 2009
    ..Our studies together provide insights into why Kaiso null mice display resistance to intestinal tumors when crossed onto an Apc(Min/+) background...
  62. pmc Transendothelial migration of melanoma cells involves N-cadherin-mediated adhesion and activation of the beta-catenin signaling pathway
    Jianfei Qi
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    Mol Biol Cell 16:4386-97. 2005
    ..Transendothelial migration was compromised in cells expressing a dominant-negative form of beta-catenin, thus supporting a regulatory role of beta-catenin signaling in this process...
  63. doi Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
    Ilaria Malanchi
    Ecole Polytechnique Fédérale de Lausanne ISREC Swiss Institute for Experimental Cancer Research and National Center of Competence in Research Molecular Oncology, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Nature 452:650-3. 2008
    ..Because Wnt/beta-catenin signalling is not essential for normal epidermal homeostasis, such a mechanistic difference may thus be targeted to eliminate CSCs and consequently eradicate squamous cell carcinomas...
  64. ncbi Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
    B Rubinfeld
    Onyx Pharmaceuticals, Richmond, CA 94806, USA
    Science 272:1023-6. 1996
    ..The APC protein binds to the cellular adhesion molecule beta-catenin, which is a mammalian homolog of ARMADILLO, a component of the WINGLESS signaling pathway in Drosophila development...
  65. ncbi Regulation of beta-catenin structure and activity by tyrosine phosphorylation
    J Piedra
    Unitat de Biologia Cel lular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    J Biol Chem 276:20436-43. 2001
    ..Phosphorylation of Tyr-654, a residue placed in the last armadillo repeat of beta-catenin, decreases its binding to E-cadherin...
  66. pmc Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination
    Shin Ichiro Hino
    Department of Biochemistry, Graduate School of Biomedical Sciences, Hiroshima University, Japan
    Mol Cell Biol 25:9063-72. 2005
    ..These results indicate that PKA inhibits the ubiquitination of beta-catenin by phosphorylating beta-catenin, thereby causing beta-catenin to accumulate and the Wnt signaling pathway to be activated...
  67. ncbi ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas
    Joyce A Schroeder
    Tumor Biology Program and Department of Biochemistry and Molecular Biology, Mayo Medical Graduate School, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, USA
    J Biol Chem 277:22692-8. 2002
    ....
  68. pmc Tyrosine residues 654 and 670 in beta-catenin are crucial in regulation of Met-beta-catenin interactions
    Gang Zeng
    Department of Pathology CMP, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Exp Cell Res 312:3620-30. 2006
    ..Thus, intact 654 and 670 tyrosine residues in beta-catenin are crucial in HGF-mediated beta-catenin translocation, activation and mitogenesis...
  69. ncbi Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes
    Satdarshan P S Monga
    Division of Cellular and Molecular Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Cancer Res 62:2064-71. 2002
    ..Part of the multifunctionality of HGF might be attributable to nuclear beta-catenin and the resulting target gene expression...
  70. ncbi Involvement of claudin-1 in the beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers
    N Miwa
    Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Japan
    Oncol Res 12:469-76. 2001
    ..Our results imply that claudin-1 is involved in the beta-catenin-Tcf/LEF signaling pathway, and that increased expression of claudin-1 may have some role in colorectal tumorigenesis...
  71. doi Nuclear GSK-3beta inhibits the canonical Wnt signalling pathway in a beta-catenin phosphorylation-independent manner
    M Caspi
    Department of Anatomy and Anthropology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Oncogene 27:3546-55. 2008
    ..We show that GSK-3beta enters the nucleus, forms a complex with beta-catenin and lowers the levels of beta-catenin/TCF-dependent transcription in a mechanism that involves GSK-3beta-Axin binding...
  72. pmc Sulindac suppresses beta-catenin expression in human cancer cells
    Anjia Han
    Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Eur J Pharmacol 583:26-31. 2008
    ..In conclusion, our data demonstrated that the efficacy of sulindac in the inhibition of cell proliferation (rather than the induction of apoptosis) might be through the suppression of beta-catenin pathway in human cancer cells...
  73. ncbi The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin
    Jing Liu
    Department of Biological Structure, University of Washington, Seattle, WA 98195, USA
    J Mol Biol 360:133-44. 2006
    ..In addition, our CD and NMR studies demonstrate that the central region of APC is unstructured in the absence of beta-catenin and Axin, and suggest that beta-catenin may interact with each of the APC 15aa and 20aa repeats independently...
  74. pmc The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro
    J T Winston
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030 USA
    Genes Dev 13:270-83. 1999
    ..Our results suggest that an SCFbeta-TRCP complex functions in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway...
  75. ncbi Asef, a link between the tumor suppressor APC and G-protein signaling
    Y Kawasaki
    Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113, Japan
    Science 289:1194-7. 2000
    ..Here the APC gene product is shown to bind through its armadillo repeat domain to a Rac-specific guanine nucleotide exchange factor (GEF), termed Asef...
  76. pmc Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
    S Ikeda
    Department of Biochemistry, Hiroshima University School of Medicine, 1 2 3, Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    EMBO J 17:1371-84. 1998
    ..rAxin interacted directly with, and was phosphorylated by, GSK-3beta. rAxin also interacted directly with the armadillo repeats of beta-catenin...
  77. pmc Overall expression of beta-catenin outperforms its nuclear accumulation in predicting outcomes of colorectal cancers
    Worrawit Wanitsuwan
    Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110 Thailand
    World J Gastroenterol 14:6052-9. 2008
    ..To examine the expression of beta-catenin in colorectal cancer and look for association with other clinico-pathological parameters...
  78. pmc SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability
    Min Jung Kim
    Department of Genetics and Development, 701 W 168th St, Columbia University Medical Center, New York, NY 10032, USA
    FASEB J 22:3785-94. 2008
    ..Therefore, some other specific property of the C6 motif seems to reduce the interaction of Axin with Dvl-1...
  79. pmc Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene
    Benjamin Cieply
    Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261, USA
    Hepatology 49:821-31. 2009
    ..In addition, significant cases with mutations showed absence of cirrhosis. Finally, the highest levels of Y654-beta-catenin were exclusively observed in fibrolamellar (FL)-HCC cases...
  80. pmc HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies
    Tomas Valenta
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    EMBO J 25:2326-37. 2006
    ..These data indicate that the intracellular amounts of HIC1 protein can modulate the level of the transcriptional stimulation of the genes regulated by canonical Wnt/beta-catenin signaling...
  81. pmc Issues associated with assessing nuclear localization of N-terminally unphosphorylated beta-catenin with monoclonal antibody 8E7
    Meghan T Maher
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Biol Direct 4:5. 2009
    ....
  82. pmc The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes
    Jose Sierra
    Regulatory Biology Laboratory, The Salk Insitute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 20:586-600. 2006
    ..We conclude that, in addition to regulating the stability of beta-cat, APC facilitates CtBP-mediated repression of Wnt target genes in normal, but not in colorectal cancer cells...
  83. ncbi Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin
    P A Sacco
    Department of Biology, University of Toledo, Ohio 43606, USA
    J Biol Chem 270:20201-6. 1995
    ..Plakoglobin is an armadillo family member containing 13 weakly similar internal repeats...
  84. ncbi Wnt signaling controls the phosphorylation status of beta-catenin
    Mascha van Noort
    Department of Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Biol Chem 277:17901-5. 2002
    ..Immunohistochemical analysis of mouse embryos utilizing the antibody visualizes sites that transduce Wnt signals through the canonical Wnt cascade...
  85. pmc EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin
    Haitao Ji
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Mol Cell 36:547-59. 2009
    ..This EGFR-ERK-CK2-mediated phosphorylation of alpha-catenin promotes beta-catenin transactivation and tumor cell invasion. These findings highlight the importance of the crosstalk between EGFR and Wnt pathways in tumor development...
  86. ncbi Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
    Nam Chul Ha
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94043, USA
    Mol Cell 15:511-21. 2004
    ..Phosphorylated APC and axin bind to the same surface of, and compete directly for, beta-catenin. The structural and biochemical data suggest a novel model for how APC functions in beta-catenin degradation...
  87. doi Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients
    E M Kohler
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nurnberg, Erlangen, Bayern, Germany
    Oncogene 29:1663-71. 2010
    ..The analysis of the distribution of truncating mutations along the APC sequence in colorectal tumours from FAP patients revealed that the first 15R is one target of the positive selection of mutations that lead to tumour development...
  88. doi Phosphorylation of β-catenin results in lack of β-catenin signaling in melanoma
    Silke Kuphal
    University of Regensburg, Institute of Pathology, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Int J Oncol 39:235-43. 2011
    ..In summary, this study suggests a cell type-specific regulation of β-catenin function. This alternative β-catenin signaling pathway should be considered when thinking about targeting β-catenin in melanoma treatment...
  89. doi Aberrant changes of Wnt2/beta-catenin signaling pathway induced by sodium nitroprusside in human esophageal squamous cell carcinoma cell lines
    Wei Wang
    Laboratory for Cell Biology, The First Affiliated Hospital, Zhengzhou University, 40 Daxue Road, Zhengzhou, Henan 450052, China
    Cancer Invest 28:230-41. 2010
    ....
  90. doi Activation of voltage gated K⁺ channel Kv1.5 by β-catenin
    Carlos Munoz
    Department of Physiology, University of Tubingen, Gmelinstr 5, D 72076 Tubingen, Germany
    Biochem Biophys Res Commun 417:692-6. 2012
    ..5 requires the same protein domains that are required for association of β-catenin with cadherin. The experiments disclose a completely novel function of β-catenin, i.e. the regulation of Kv1.5 channel activity...
  91. pmc Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors
    D Levanon
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 95:11590-5. 1998
    ..signaling pathway through interactions with the coactivator beta-catenin and its highly conserved fly homolog Armadillo (Arm)...
  92. pmc A protein knockdown strategy to study the function of beta-catenin in tumorigenesis
    Feng Cong
    Program in Cell Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    BMC Mol Biol 4:10. 2003
    ..Aberrant Wnt signaling, which results from mutations of either beta-catenin or adenomatous polyposis coli (APC), renders beta-catenin resistant to degradation, and has been associated with multiple types of human cancers...
  93. pmc β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation
    I Ahmad
    The Beatson Institute for Cancer Research, Glasgow, Scotland, UK
    Oncogene 30:178-89. 2011
    ..Taken together these data show that deregulated Wnt signalling has a critical role in promoting UCC, and suggests that human UCC that have high levels of Wnt and PI3 kinase signalling may be responsive to mTOR inhibition...
  94. pmc Correlation between beta-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma
    Madeleine Austinat
    Institute for Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    Mol Cancer 7:21. 2008
    ....
  95. doi The complex intratumoral heterogeneity of colon cancer highlighted by laser microdissection
    David Buob
    Department of Pathology, CHRU de Lille, Centre de Biologie Pathologie, Avenue Oscar Lambret, 59037 Lille Cedex, France
    Dig Dis Sci 57:1271-80. 2012
    ..To evaluate the utility of laser microdissection in the comparison of phenotypes and genetic alterations between colon cancer and corresponding liver metastasis in the context of intratumoral heterogeneity...
  96. pmc beta-Catenin is a Nek2 substrate involved in centrosome separation
    Shirin Bahmanyar
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Genes Dev 22:91-105. 2008
    ..These results identify beta-catenin as a component of the intercentrosomal linker and define a new function for beta-catenin as a key regulator of mitotic centrosome separation...
  97. pmc Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma
    Gang Zeng
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Neoplasia 8:279-89. 2006
    ..Thus, Wnt/beta-catenin activation was observed in 65% of pancreatic adenocarcinomas, independently of beta-catenin gene mutations in most tumors...
  98. pmc Enhanced interaction between focal adhesion and adherens junction proteins: involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement
    Xiaoguang Sun
    Department of Medicine, Division of Biological Sciences, The University of Chicago, 5841 Maryland Ave, Chicago, IL 60637 1470, USA
    Microvasc Res 77:304-13. 2009
    ..These results demonstrate a mechanism of S1P-induced endothelial barrier enhancement via beta-catenin-linked adherens junction and focal adhesion interaction...
  99. ncbi Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
    Abdolrahman S Nateri
    Mammalian Genetics Laboratory, CR UK London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nature 437:281-5. 2005
    ..Therefore, the phosphorylation-dependent interaction between c-Jun and TCF4 regulates intestinal tumorigenesis by integrating JNK and APC/beta-catenin, two distinct pathways activated by WNT signalling...
  100. doi Target gene activation of the Wnt signaling pathway in nuclear beta-catenin accumulating cells of adamantinomatous craniopharyngiomas
    Annett Hölsken
    Departments of Neuropathology Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Brain Pathol 19:357-64. 2009
    ..The results confirm the Wnt signaling pathway as molecular basis of the distinct and challenging clinical and morphological phenotype of adaCP...
  101. ncbi Expression and clinical significance of Wnt-1 and beta-catenin in nasopharyngeal carcinoma
    Fei Li Wang
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, Guangdong, PR China
    Ai Zheng 28:72-5. 2009
    ..This study was to investigate the expression and clinical significance of Wnt-1 and beta-catenin in nasopharyngeal carcinoma (NPC)...

Research Grants91

  1. Role of Ectodermal Signals in Facial Prominence Outgrowth and Development
    Trevor J Williams; Fiscal Year: 2010
    ....
  2. BETA-CATENIN AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CANCER
    SATDARSHAN MONGA; Fiscal Year: 2007
    ..Thus this proposal will lay the ground work for initiating clinical studies directed against ¿-catenin in HCC. ..
  3. BETA-CATENIN AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CANCER
    SATDARSHAN MONGA; Fiscal Year: 2009
    ..Thus this proposal will lay the ground work for initiating clinical studies directed against -catenin in HCC. ..
  4. BETA-CATENIN AS A THERAPEUTIC TARGET IN HEPATOCELLULAR CANCER
    SATDARSHAN SINGH MONGA; Fiscal Year: 2010
    ..Thus this proposal will lay the ground work for initiating clinical studies directed against -catenin in HCC. ..
  5. MSX2-Wnt Signaling in Cardiovascular Calcification
    Dwight A Towler; Fiscal Year: 2010
    ..We test whether regulation of these proteins reduces arterial hardening, decreases cardiac workload, and improves blood flow to the foot. ..
  6. WT1 and beta-catenin targets in Wilms tumor
    Benjamin Tycko; Fiscal Year: 2007
    ..other phosphorylation sites in affecting the proliferative/oncogenic potency of beta-catenin. We will subsequently cross these mice with Wt1-mutant heterozygotes, possibly generating a mouse model for Wilms tumor. ..
  7. Molecular Pathogenesis of Ovarian Endometrioid Adenocarc
    KATHLEEN CHO; Fiscal Year: 2006
    ..abstract_text> ..
  8. Molecular Pathogenesis of Ovarian Endometrioid Adenocarcinomas
    KATHLEEN CHO; Fiscal Year: 2009
    ....
  9. Molecular Pathogenesis of Ovarian Endometrioid Adenocarcinomas
    Kathleen R Cho; Fiscal Year: 2010
    ....
  10. Molecular Pathogenesis of Ovarian Endometrioid Adenocarcinomas
    KATHLEEN CHO; Fiscal Year: 2007
    ....
  11. MOLECULAR EPIDEMIOLOGY OF COLORECTAL CANCER
    Shuji Ogino; Fiscal Year: 2007
    ..Charles Fuchs, a well-established researcher in clinical oncology and epidemiology. At the completion of the projects, I will have gained the experience to become an independent researcher in cancer epidemiology. ..
  12. Deciphering Beta-Catenin Contributions in Prostate Cance
    David Mulholland; Fiscal Year: 2007
    ..These cells will be assessed for growth and PSA secretion in tumours carried as xenografts. These novel in vivo tools will allow understanding to the role of Beta-catenin has in Al PrCa. ..
  13. Epigenetic Events and Colorectal Cancer Epidemiology
    Shuji Ogino; Fiscal Year: 2010
    ..Through better understanding of epigenetic mechanisms of colorectal cancer development and progression, we can provide a scientific basis for dietary recommendations and help optimize preventive strategies. ..
  14. The Biology and Function of BMP-7 in the Kidney
    Raghu Kalluri; Fiscal Year: 2007
    ..The physiological role of BMP-7 in kidney health and pathology will be established. These studies will directly benefit the development of this molecule in the clinic as a drug for patients with kidney fibrosis. ..
  15. Role for Wnt/beta-catenin signaling in alveolar repair and fibrosis
    Cara J Gottardi; Fiscal Year: 2011
    ..Thus, new insights into the mechanisms of pulmonary fibrosis are needed to generate novel therapeutic treatments. ..
  16. ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE
    Raghu Kalluri; Fiscal Year: 2001
    ..Successful completion of this project should provide new experimental information regarding the processes that govern the pathogenesis of human anti-GBM disease. ..
  17. Regulation and Function of MAPKAP Kinases
    Thomas Sturgill; Fiscal Year: 2005
    ..Aim four is to characterize the activation, enzymatic properties, and functions of MAPKAP kinase-like enzymes (Rcklp, Rck2p) in yeast, a model eukaryote, using combined biochemical and genetic approaches. ..
  18. mTOR Signaling Pathways
    Thomas Sturgill; Fiscal Year: 2009
    ..We will investigate novel candidate mTOR-interacting proteins identified by MS. Finally, to understand better the mechanisms involved in mTORC2, we propose to identify pianissimo-interacting proteins. ..
  19. Role of Fibroblasts in Cancer
    Raghu Kalluri; Fiscal Year: 2010
    ..The role of such fibroblasts in cancer progression and metastasis is unknown. This proposal addresses the role of fibroblasts in facilitating metastasis. ..
  20. Novel Therapeutic Strategies for PKD
    Patricia Wilson; Fiscal Year: 2007
    ..abstract_text> ..
  21. Epigenetic changes and phenotype-specific therapeutic strategies in breast cancer
    Stefanie S Jeffrey; Fiscal Year: 2010
    ..This proposal should demonstrate how tumor biology and genomic signatures can be translated into strategies for personalized cancer treatment. ..
  22. Role of Wnt/Frizzled signaling during eye development
    Sabine Fuhrmann; Fiscal Year: 2007
    ..We will use a reporter of Wnt/beta catenin signaling in transgenic Xenopus and mouse embryos to define when and where during eye development this ..
  23. Role of Fibroblasts in Cancer
    Raghu Kalluri; Fiscal Year: 2009
    ..The role of such fibroblasts in cancer progression and metastasis is unknown. This proposal addresses the role of fibroblasts in facilitating metastasis. ..
  24. Role of Fibroblasts in Cancer
    Raghu Kalluri; Fiscal Year: 2010
    ..The role of such fibroblasts in cancer progression and metastasis is unknown. This proposal addresses the role of fibroblasts in facilitating metastasis. ..
  25. Mice That Lack CDO: A Model for Mild Holoprosencephaly
    ROBERT KRAUSS; Fiscal Year: 2004
    ....
  26. Mechanism of b-catenin targeting to adhesive or transcriptional complexes
    CARA GOTTARDI; Fiscal Year: 2007
    ....
  27. mTOR Signaling Pathways
    Thomas W Sturgill; Fiscal Year: 2010
    ..We will investigate novel candidate mTOR-interacting proteins identified by MS. Finally, to understand better the mechanisms involved in mTORC2, we propose to identify pianissimo-interacting proteins. ..
  28. Role of Plakophilin-1 in HNSCC
    James Wahl; Fiscal Year: 2007
    ..Plakophilin-1 is a member of the Armadillo (Arm) protein family that is a structural component of the cell-cell adhesion junction known as the desmosome...
  29. Gene-Environment Interaction in Holoprosencephaly: Role of Fetal Alcohol Exposure
    ROBERT KRAUSS; Fiscal Year: 2007
    ..Such information may have important public health impact and could ultimately aid in the counseling of HPE mutation carriers. ..
  30. THE ROLE OF CDO IN MYOGENIC DIFFERENTIATION
    ROBERT KRAUSS; Fiscal Year: 2009
    ..This research should shed light on fundamental processes by which skeletal muscles develop and therefore advance potential strategies for improved treatment of skeletal muscle diseases. ..
  31. APC PATHWAY--A TARGET FOR CHEMOPREVENTIVE INTERVENTION
    Wen Chi Chang; Fiscal Year: 2005
    ..in nutritional biochemistry when combined with the proposed training in cancer prevention and molecular genetics will provide her with the unique ability to develop both natural and synthetic compounds as clinical chemopreventive agents ..
  32. Role of Plakophilin-1 in HNSCC
    James Wahl; Fiscal Year: 2009
    ..Plakophilin-1 is a member of the Armadillo (Arm) protein family that is a structural component of the cell-cell adhesion junction known as the desmosome...
  33. Early Events in Colitis-Associated Colorectal Cancer
    Wen Chi Chang; Fiscal Year: 2003
    ..abstract_text> ..
  34. Matrix Microenvironment and Liver Fibrosis
    Raghu Kalluri; Fiscal Year: 2007
    ..Therefore, this application is well poised to identify a unique mechanism of liver fibrosis and also study a therapeutic agent, which works against this mechanism and inhibits progression of liver disease. ..
  35. Assembly of type IV collagen in health and disease
    Raghu Kalluri; Fiscal Year: 2009
    ..We expect this grant application to provide basic understanding of the assembly and function of type IV collagen in the GBM. ..
  36. Role of Plakophilin-1 in HNSCC
    James Wahl; Fiscal Year: 2006
    ..Plakophilin-1 is a member of the Armadillo (Arm) protein family that is a structural component of the cell-cell adhesion junction known as the desmosome...
  37. Regulation of Angiogenesis by Tumstatin
    Raghu Kalluri; Fiscal Year: 2006
    ..abstract_text> ..
  38. Molecular Function of the Nf2 Tumor Suppressor, Merlin
    Andrea McClatchey; Fiscal Year: 2009
    ..The results of this study will yield important insight into the mechanism of Merlin function as a tumor suppressor and identify novel targets for therapeutic intervention of NF2. ..