Genomes and Genes
Gene Symbol: BEST1
Description: bestrophin 1
Alias: ARB, BEST, BMD, RP50, TU15B, VMD2, Best disease, Best1V1Delta2, bestrophin-1, vitelliform macular dystrophy protein 2
Publications222 found, 100 shown here
- Long-term results of radiofrequency rhizotomy in the treatment of cluster headacheJ M Taha
Department of Neurosurgery, University of Cincinnati College of Medicine, OH 45267-0515, USA
Headache 35:193-6. 1995..reviewed the charts of seven patients (ages 36 to 68 years) with chronic cluster headache to identify who responded best to percutaneous stereotactic radiofrequency rhizotomy after medical treatment failed...
- [High-dose chemotherapy and peripheral hemtopoietic cells (PBPC) in solid tumors]G Rosti
Oncologia Medica Ravenna, Istituto Oncologico Romagnoto, Ravenna
Tumori 82:S19-22. 1996..The best results had been reported by Peters and Gianni; with a minimum follow-up of 5 years 65 and 56% of their patients ..
- Hemodilution as a method to reduce transfusion requirements in adolescent spine fusion surgeryL A Copley
Department of Orthopaedic Surgery, Eglin Air Force Base, Florida, USA
Spine (Phila Pa 1976) 24:219-22; discussion 223-4. 1999..Although all methods have some efficacy, it is not clear which methods, separate or combined, are best in the adolescent scoliosis population...
- [The best of thrombosis and thromboembolic disease in 1999]E Ferrari
Service de cardiologie, , Nice
Arch Mal Coeur Vaiss 93:77-81. 2000..This emphasises the importance of early diagnosis which is usually possible without resorting to invasive procedures and by modulating all the results of paraclinical investigations with respect to the pretest clinical probability...
- Best's vitelliform macular dystrophy caused by a new mutation (Val89Ala) in the VMD2 geneL Eksandh
Department of Ophthalmology, University Hospital, Lund, Sweden
Ophthalmic Genet 22:107-15. 2001To describe the clinical phenotype in a family with Best's vitelliform macular dystrophy (BMD) and a new mutation (Val89Ala) in the VMD2 gene.
- The spectrum of ocular phenotypes caused by mutations in the BEST1 geneCamiel J F Boon
Department of Ophthalmology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Prog Retin Eye Res 28:187-205. 2009Bestrophin-1 is an integral membrane protein, encoded by the BEST1 gene, which is located in the basolateral membrane of the retinal pigment epithelium...
- Functional and clinical data of Best vitelliform macular dystrophy patients with mutations in the BEST1 geneGiuseppe Querques
Department of Ophthalmology, Hopital Intercommunal de Creteil, University Paris XII, Paris, France
Mol Vis 15:2960-72. 2009To analyze functional and clinical data of Best vitelliform macular dystrophy (VMD) patients with mutations in the BEST1 gene.
- Functional roles of bestrophins in ocular epitheliaAlan D Marmorstein
Department of Ophthalmology and Vision Science, University of Arizona, Tucson, AZ 85711, USA
Prog Retin Eye Res 28:206-26. 2009..The gene BEST1 (formerly VMD2) which encodes the protein bestrophin-1 (Best1) was first identified in 1998...
- Mutations in the VMD2 gene are associated with juvenile-onset vitelliform macular dystrophy (Best disease) and adult vitelliform macular dystrophy but not age-related macular degenerationF Kramer
Institut fur Humangenetik, Universitat Wurzburg, Germany
Eur J Hum Genet 8:286-92. 2000..the VMD2 gene has been identified as the causative gene in juvenile-onset vitelliform macular dystrophy (Best disease), a central retinopathy primarily characterised by an impaired function of the retinal pigment epithelium...
- Morphological and functional changes in multifocal vitelliform retinopathy and biallelic mutations in BEST1Elisabeth Wittström
Department of Ophthalmology, Lund University, Sweden
Ophthalmic Genet 32:83-96. 2011To describe morphological and functional changes in a single patient with multifocal Best vitelliform macular dystrophy (BVMD) and to perform a genotype/phenotype correlation.
- Bestrophin gene mutations in patients with Best vitelliform macular dystrophyG M Caldwell
Department of Cancer Genetics, Roswell Park Cancer Institute, 666 Elm Street, Buffalo, New York 14263, USA
Genomics 58:98-101. 1999b>Best vitelliform macular dystrophy (VMD2) is an autosomal dominant dystrophy with a juvenile age of onset. Mutations in the Bestrophin gene were shown in patients affected with VMD2...
- Differential macular and peripheral expression of bestrophin in human eyes and its implication for best diseaseRobert F Mullins
Carver Family Center for Macular Degeneration, Department of Ophthalmology and Visual Science, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
Invest Ophthalmol Vis Sci 48:3372-80. 2007b>Best disease, or vitelliform macular degeneration, is an autosomal dominant form of macular degeneration that is caused by mutations in the gene encoding bestrophin...
- Variant phenotype of Best vitelliform macular dystrophy associated with compound heterozygous mutations in VMD2Patrik Schatz
Department of Ophthalmology, Lund University Hospital, Lund, Sweden
Ophthalmic Genet 27:51-6. 2006To characterize the phenotype of members of a Swedish family with Best macular dystrophy and two distinct mutations in VMD2.
- Clinical and genetic heterogeneity in multifocal vitelliform dystrophyCamiel J F Boon
Department of Ophthalmology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Arch Ophthalmol 125:1100-6. 2007..To describe the clinical and genetic findings in 15 patients with multifocal vitelliform lesions...
- Late onset is common in best macular dystrophy associated with VMD2 gene mutationsAgnes B Renner
Augenklinik, Charite Campus Benjamin Franklin, Universitatsmedizin Berlin, Berlin, Germany
Ophthalmology 112:586-92. 2005To perform a detailed morphologic and functional evaluation of Best macular dystrophy (BMD) associated with mutations in the VMD2 gene.
- Autosomal recessive vitelliform macular dystrophy in a large cohort of vitelliform macular dystrophy patientsTyson R Kinnick
Department of Ophthalmology and Visual Sciences, Carver Family Center for Macular Degeneration, University of Iowa, Iowa City, Iowa 52242, USA
Retina 31:581-95. 2011..To report 11 cases of autosomal recessive vitelliform macular dystrophy and to compare their molecular findings and phenotypic characteristics with those of patients with the more common and well-described dominant form of the disease...
- Missense mutations in a retinal pigment epithelium protein, bestrophin-1, cause retinitis pigmentosaAlice E Davidson
Genetic Medicine, The University of Manchester, Manchester Academic Heath Science Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK
Am J Hum Genet 85:581-92. 2009..Mutations in the BEST1 gene cause the retinal dystrophies vitelliform macular dystrophy, autosomal-dominant vitreochoroidopathy, and ..
- Eag1 and Bestrophin 1 are up-regulated in fast-growing colonic cancer cellsMelanie Spitzner
Institut fur Physiologie, Universitat Regensburg, Universitatsstrasse 31, D 93053 Regensburg, Germany
J Biol Chem 283:7421-8. 2008..b>Bestrophin 1 (Best1) has been proposed to form Ca(2+)-activated Cl(-) channels in epithelial cells...
- Genotype-phenotype correlation and longitudinal course in ten families with Best vitelliform macular dystrophyB Wabbels
Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics, University of Regensburg, Klinikum, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
Graefes Arch Clin Exp Ophthalmol 244:1453-66. 2006..Longitudinal course and genotype-phenotype correlation in patients and carriers with heterozygous mutations in hBEST1 (bestrophin)...
- Novel and homozygous BEST1 mutations in Chinese patients with Best vitelliform macular dystrophyRaymond L M Wong
Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Kowloon, Hong Kong SAR, China
Retina 30:820-7. 2010The purpose of this study was to investigate the BEST1 gene mutations in Chinese patients with Best vitelliform macular dystrophy (BVMD).
- Evaluation of macular structure and function by OCT and electrophysiology in patients with vitelliform macular dystrophy due to mutations in BEST1Patrik Schatz
Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
Invest Ophthalmol Vis Sci 51:4754-65. 2010To analyze retinal structure and function in vitelliform macular dystrophy (VMD) due to mutations in BEST1.
- Phenotypic variability in a French family with a novel mutation in the BEST1 gene causing multifocal best vitelliform macular dystrophyEmmanuelle Lacassagne
Universite Paris Descartes, Faculté de Médecine Paris Descartes site Necker, CERTO, Paris, France
Mol Vis 17:309-22. 2011To describe genetic and clinical findings in a French family affected by best vitelliform macular dystrophy (BVMD).
- Identification of the gene responsible for Best macular dystrophyK Petrukhin
Department of Human Genetics, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
Nat Genet 19:241-7. 1998b>Best macular dystrophy (BMD), also known as vitelliform macular dystrophy (VMD2; OMIM 153700), is an autosomal dominant form of macular degeneration characterized by an abnormal accumulation of lipofuscin within and beneath the retinal ..
- Allelic variation in the VMD2 gene in best disease and age-related macular degenerationA J Lotery
Department of Ophthalmology, The University of Iowa College of Medicine, Iowa City 52242, USA
Invest Ophthalmol Vis Sci 41:1291-6. 2000To assess the allelic variation of the VMD2 gene in patients with Best disease and age-related macular degeneration (AMD).
- Calcium-dependent chloride conductance in epithelia: is there a contribution by Bestrophin?Karl Kunzelmann
Institut fur Physiologie, Universitat Regensburg, Universitatsstrasse 31, 93053, Regensburg, Germany
Pflugers Arch 454:879-89. 2007..Mutations in the bestrophin gene cause an autosomal form of macular dystrophy of the retina. Bestrophin 1 is assumed to form the basolateral Ca(2+)-activated Cl(-) channel in the retinal pigment epithelium of the eye...
- Human disease-causing mutations disrupt an N-C-terminal interaction and channel function of bestrophin 1Zhiqiang Qu
Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 284:16473-81. 2009Mutations in the human bestrophin 1 (hBest1) chloride channel cause Best vitelliform macular dystrophy...
- Biallelic mutation of BEST1 causes a distinct retinopathy in humansRosemary Burgess
Academic Unit of Medical Genetics and Regional Genetics Service, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, UK
Am J Hum Genet 82:19-31. 2008..However, unlike two other alleles previously associated with Best disease, cotransfection with wild-type bestrophin-1 did not impair the formation of active wild-type bestrophin-1 ..
- Bestrophins and retinopathiesQinghuan Xiao
Department of Cell Biology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
Pflugers Arch 460:559-69. 2010b>Best vitelliform macular dystrophy (BVMD, also called Best's disease) is a dominantly inherited, juvenile-onset form of macular degeneration, which is characterized by abnormal accumulation of yellow pigment in the outer retina and a ..
- Bestrophin Cl- channels are highly permeable to HCO3-Zhiqiang Qu
Department of Cell Biology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322 3030, USA
Am J Physiol Cell Physiol 294:C1371-7. 2008Bestrophin-1 (Best1) is a Cl(-) channel that is linked to various retinopathies in both humans and dogs...
- Three novel human VMD2-like genes are members of the evolutionary highly conserved RFP-TM familyHeidi Stohr
Institut fur Humangenetik, Universitat Wurzburg, Germany
Eur J Hum Genet 10:281-4. 2002..The VMD2 gene underlying Best disease was shown to represent the first human member of the RFP-TM protein family...
- The vitelliform macular dystrophy protein defines a new family of chloride channelsHui Sun
Department of Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 99:4008-13. 2002Vitelliform macular dystrophy (VMD/Best disease; MIM*153700) is an early-onset autosomal dominant disorder in which accumulation of lipofuscin-like material within and beneath the retinal pigment epithelium is associated with a ..
- Regulation of bestrophin Cl channels by calcium: role of the C terminusQinghuan Xiao
Department of Cell Biology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
J Gen Physiol 132:681-92. 2008..Many of the approximately 100 disease-causing mutations in hBest1 are located in this region that we have implicated in Ca(2+) sensing, suggesting that these mutations disrupt hBest1 channel gating by Ca(2+)...
- Bestrophin, the product of the Best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epitheliumA D Marmorstein
Department of Ophthalmic Research, Cole Eye Institute, and Department of Cell Biology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195, USA
Proc Natl Acad Sci U S A 97:12758-63. 2000..Although the vitelliform lesion is common in the fundus of individuals with Best disease, diagnosis is based on a reduced ratio of the light peak to dark trough in the electrooculogram...
- Evaluation of the Best disease gene in patients with age-related macular degeneration and other maculopathiesR Allikmets
Intramural Research Support Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, MD 21702 1201, USA
Hum Genet 104:449-53. 1999Vitelliform macular dystrophy (VMD2, Best disease, MIM153700) is an early onset, autosomal, dominant macular degeneration characterized by the deposition of lipofuscin-like material within and below the retinal pigment epithelium (RPE); ..
- The mutation spectrum of the bestrophin protein--functional implicationsB Bakall
Department of Genetics and Pathology, University Hospital, Uppsala, Sweden
Hum Genet 104:383-9. 1999b>Best's macular dystrophy (BMD), also known as vitelliform macular degeneration type 2 (VMD2; OMIM 153700), is an autosomal dominant form of macular degeneration with mainly juvenile onset...
- A gene map of the Best's vitelliform macular dystrophy region in chromosome 11q12-q13.1H Stohr
Institute of Human Genetics, University of Wurzburg, Germany
Genome Res 8:48-56. 1998b>Best's vitelliform macular dystrophy is an autosomal dominant disorder of unknown causes. To identify the underlying gene defect the disease locus has been mapped to an approximately 1.4-Mb region on chromosome 11q12-q13.1...
- Structure-function analysis of the bestrophin family of anion channelsTakashi Tsunenari
Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Biol Chem 278:41114-25. 2003..These experiments provide the first structural analysis of the bestrophin channel family...
- The anion-selective pore of the bestrophins, a family of chloride channels associated with retinal degenerationZhiqiang Qu
Department of Cell Biology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Neurosci 26:5411-9. 2006Mutations in human bestrophin-1 (VMD2) are genetically linked to a juvenile form of macular degeneration and autosomal dominant vitreoretinochoroidopathy...
- Hereditary maculardegeneration (HMD) in 246 cases traced to one gene-source in central SwedenS Nordstrom
Hereditas 84:163-76. 1977
- Genetic linkage of vitelliform macular degeneration (Best's disease) to chromosome 11q13E M Stone
Department of Ophthalmology, University of Iowa, College of Medicine, Iowa City 52242
Nat Genet 1:246-50. 1992Macular degeneration is the most common cause of legal blindness in older patients in developed countries. Best's vitelliform dystrophy is an early-onset, autosomal dominant form of macular degeneration characterized by an egg-yolk-like ..
- Bestrophin-1 enables Ca2+-activated Cl- conductance in epitheliaRene Barro Soria
Institut fur Physiologie, Universitat Regensburg, Universitätsstrabetae 31, D 93053 Regensburg, Germany
J Biol Chem 284:29405-12. 2009..Here, we demonstrate molecular and functional expression of bestrophin-1 (BEST1) in mouse and human airways, colon, and kidney...
- Insertion and topology of normal and mutant bestrophin-1 in the endoplasmic reticulum membraneVladimir M Milenkovic
Institute of Physiology, University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
J Biol Chem 282:1313-21. 2007The vitelliform macular dystrophy type 2 (VMD2) gene mutated in Best macular dystrophy encodes a 585-amino acid putative transmembrane protein termed bestrophin-1...
- The role of bestrophin in airway epithelial ion transportValentin Duta
Department of Physiology, University of Alberta, 7 46 Med Sci Bldg Edmonton, Alta, Canada T6G 2H7
FEBS Lett 577:551-4. 2004..The data indicate that the presence of a functional bestrophin may contribute to the basolateral cell conductance in airway epithelial cells...
- Clinical and molecular genetic analysis of best vitelliform macular dystrophyCamiel J F Boon
Department of Ophthalmology, Radboud University Nijmegen Medical Centre, The Netherlands
Retina 29:835-47. 2009To describe the phenotype of Best vitelliform macular dystrophy (BVMD) and to evaluate genotype-phenotype and histopathologic correlations.
- The bestrophin mutation A243V, linked to adult-onset vitelliform macular dystrophy, impairs its chloride channel functionKuai Yu
Department of Cell Biology, The Center for Neurodegenerative Disease, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
Invest Ophthalmol Vis Sci 47:4956-61. 2006It has been proposed that Best vitelliform macular dystrophy (BVMD) is caused by dysfunction in the Cl(-) channel function of human bestrophin-1 (hBest1), but some patients with BVMD who have the hBest1 A243V mutation have normal electro-..
- VMD2 mutations in vitelliform macular dystrophy (Best disease) and other maculopathiesK White
Institut fur Humangenetik, Universitat Wurzburg, Wurzburg, Germany
Hum Mutat 15:301-8. 2000Mutations in the gene VMD2 are associated with autosomal dominant vitelliform macular dystrophy (Best disease)...
- Mutations of VMD2 splicing regulators cause nanophthalmos and autosomal dominant vitreoretinochoroidopathy (ADVIRC)Jill Yardley
Academic Unit of Medical Genetics and Regional Genetics Service, St Mary s Hospital, Manchester, United Kingdom
Invest Ophthalmol Vis Sci 45:3683-9. 2004..To investigate the genetic basis of autosomal dominant vitreoretinochoroidopathy (ADVIRC), a rare, inherited retinal dystrophy that may be associated with defects of ocular development, including nanophthalmos...
- Mutations in a novel gene, VMD2, encoding a protein of unknown properties cause juvenile-onset vitelliform macular dystrophy (Best's disease)A Marquardt
Institut fur Humangenetik, Universitat Wurzburg, D 97074 Wurzburg, Germany
Hum Mol Genet 7:1517-25. 1998Vitelliform macular dystrophy (Best's disease) is an autosomal dominant, early-onset form of macular degeneration in which the primary defect is thought to occur at the level of the retinal pigment epithelium...
- New VMD2 gene mutations identified in patients affected by Best vitelliform macular dystrophyD Marchant
Centre de Recherche Thérapeutique en Ophtalmologie, Equipe d accueil 2502 MENRT, Universite Rene Descartes Paris V, Faculte de Medecine Necker Enfants Malades, Paris, France
J Med Genet 44:e70. 2007The mutations responsible for Best vitelliform macular dystrophy (BVMD) are found in a gene called VMD2. The VMD2 gene encodes a transmembrane protein named bestrophin-1 (hBest1) which is a Ca(2+)-sensitive chloride channel...
- 1995 Volvo Award in clinical sciences. The diagnostic accuracy of magnetic resonance imaging, work perception, and psychosocial factors in identifying symptomatic disc herniationsN Boos
Department of Orthopaedic Surgery, Inselspital, Switzerland
Spine (Phila Pa 1976) 20:2613-25. 1995..Stepwise discriminating analysis was used to identify the best discriminating variables within the magnetic resonance image, work perception, and psychosocial categories in terms ..
- Basic and therapeutic trial results obtained in the spontaneous AK leukemia (lymphoma) model-end of 1971H E Skipper
Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, AL, USA
Cancer Chemother Rep 56:273-87, 289-314. 1972..The best responses observed to date with two-drug combinations appear better on several scores than the best that have been ..
- [3H]-idazoxan binding to rabbit cerebral cortex recognises multiple imidazoline I2-type receptors: pharmacological characterization and relationship to monoamine oxidaseA Renouard
Institut de Recherches Servier, Surenes, France
Br J Pharmacol 109:625-31. 1993..01) and computer analysis showed that the [3H]-idazoxan binding data could be best fitted to a model which considers binding to two sites (P < 0.01)...
- [Functional capacity (dyspnea) and quality of life in patients with chronic obstructive lung disease (COPD): instruments of assessment and methodological aspects]B O Hütter
Neurochirurgische Klinik, Universitätsklinikum der Rheinisch Westfälischen Technischen Hochschule RWTH Aachen
Pneumologie 53:133-42. 1999..A critical review of current measures for dyspnea reveals at best an only fair association between perceived dyspnea and physiological lung function, sharing not more than 30% of ..
- [Interventional radiology in the palliative treatment of pancreatic cancer]E Mazza
Dipartimento di Fisiopatologia Clinica, , Italia
Tumori 85:S54-9. 1999..Follow-up related to 85 patients shows survival rate covered between 30 and 570 days (mean, 142). Best survival values occurred in patients who underwent "one step" technique...
- A longitudinal study of the perimenopausal transition: altered profiles of steroid and pituitary hormones, SHBG and bone mineral densityG Rannevik
Department of Obstetrics and Gynecology, University of Lund, , Sweden
Maturitas 21:103-13. 1995..Measurements of bone mineral density (BMD) on the forearm were performed every second year...
- Discovering the right questions--our call to action--who will define health care rationing, and how?R I Burton
Department of Orthopaedics, University of Rochester Medical Center, NY 14642 000
J Hand Surg Am 19:169-80. 1994..care system are needed and it must be improved, but does that justify totally changing a system providing the best care in the world for 200 million people? Or should we build on and improve that which is good and extend it to the ..
- Exfoliation syndrome and exfoliation glaucomaE Vesti
Glaucoma Service, Department of Ophthalmology, Helsinki University Central Hospital, Finland
Prog Retin Eye Res 19:345-68. 2000..The syndrome occurs worldwide but its prevalence seems to vary from country to country. The best-known sign of exfoliation syndrome is deposits of greyish-white material on the anterior lens surface...
- Capacity of the clinical picture to characterize low back pain relieved by facet joint anesthesia. Proposed criteria to identify patients with painful facet jointsM Revel
, , Paris, France
Spine (Phila Pa 1976) 23:1972-6; discussion 1977. 1998..an interaction between clinical group effect and injection effect, and logistic regression analysis to select the best set of variables that would be predictive of minimum pain relief of 75% after the injection...
- [The best in 2000 on thrombosis]E Ferrari
CHU de Nice, Service de cardiologie, 30, avenue de la Vole-Romaine, 06002 Nice
Arch Mal Coeur Vaiss 94:69-73. 2001..The earliest possible oral anticancer ... pardon me I anticoagulant treatment should be prescribed and explained...
- A systematic overview of chemotherapy effects in gastric cancerK G Janunger
Department of Surgery, University Hospital, , Sweden
Acta Oncol 40:309-26. 2001..A statistically significant survival benefit has been shown in trials comparing drug combinations with a best supportive care arm in the treatment of advanced gastric cancer. However, the number of included patients is small...
- Multinucleated giant stromal tumor of the omentum: report of a case with immunohistochemical and ultrastructural investigationK W Min
Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
Ultrastruct Pathol 20:89-99. 1996..Thus far, no tumor composed of MGSC entirely, to the best of the authors' knowledge, has been reported...
- Institutional change. Experiences in two departmentsH J Humphrey
Department of Medicine, University of Chicago, IL, USA
J Gen Intern Med 12:S79-82. 1997Though the principle may seem simple or fundamental it has been our experience that the best way to develop clinician-educators in an academic setting is to value their contributions...
- [Aerosol disinfection of bacterial spores]U Theilen
Zentralbl Bakteriol Mikrobiol Hyg B 184:229-52. 1987..This part is carried out in an aerosol chamber with airborne spores (laboratory experiments). The best results are obtained with peracetic acid, hydrogen peroxide and formaldehyde are effective with some restrictions...
- Between two wars. Psychoanalysis in Europe, 1918-1938S Gifford
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts
Psychiatr Clin North Am 17:649-65. 1994..Each country evolved the kind of analysis that suited it best, with a variety of institutions within the same international movement...
- Characteristics and causes of penetrating eye injuries reported to the National Eye Trauma System Registry, 1985-91L M Parver
Wilmer Eye Institute, School of Medicine, Johns Hopkins University
Public Health Rep 108:625-32. 1993..In 62 percent of the cases studied, the injured person's initial best corrected visual acuity in the injured eye was the ability to perceive hand motion, or worse...
- Interrupting the renin-angiotensin system: the role of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in the treatment of hypertensionM A Weber
Department of Medicine, The Brookdale University Hospital and Medical Center, Brooklyn, New York 11212, USA
Am J Hypertens 12:189S-194S. 1999..Angiotensin II receptor blockers (ARB) selectively block the angiotensin II type 1 (AT1) receptor that not only mediates the known effects of angiotensin ..
- Video-assisted lateral intertransverse process arthrodesis. Validation of a new minimally invasive lumbar spinal fusion technique in the rabbit and nonhuman primate (rhesus) modelsS D Boden
Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA
Spine (Phila Pa 1976) 21:2689-97. 1996..New Zealand white rabbits and five rhesus monkeys at necropsy and during nonsurvival surgeries to determine the best access routes and to develop special instruments for video-assisted lateral intertransverse process arthrodesis...
- Psychological questionnaires: do "abnormal" scores precede or follow first-time low back pain?A F Mannion
Department of Anatomy, University of Bristol, United Kingdom
Spine (Phila Pa 1976) 21:2603-11. 1996..A prospective study of psychological risk factors for first-time low back pain with repeated use of psychological questionnaires...
- Compression of the upper cervical spinal cord causing symptoms of brainstem compromise. A case reportW S Rosenberg
Department of Neurosurgery, University of California, San Francisco, USA
Spine (Phila Pa 1976) 23:1497-500. 1998..at the level of the third cervical vertebra in the absence of hindbrain herniation are unusual and, to the best of the authors' knowledge, have not been described previously...
- Testosterone enhances estradiol's effects on postmenopausal bone density and sexualityS R Davis
Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia
Maturitas 21:227-36. 1995..Cyclical oral progestins were taken by those women with an intact uterus. Thirty-two women completed the study. BMD (DEXA) of total body, lumbar vertebrae (L1-L4) and hip area increased significantly in both treatment groups...
- Bone mineral density is inversely related to parathyroid hormone in adolescent girlsD Bonofiglio
Dept. of Pharmaco-Biology, University of Calabria, Rende (CS, Italy
Horm Metab Res 33:170-4. 2001..Dietary calcium and energy intakes were assessed by a 3-day food record method, bone mineral density (BMD) was performed at ultradistal (ud) and proximal (pr) radial sites using dual energy X-ray absorptiometry...
- Biomechanics of vibration reception in the bullfrog, Rana catesbeianaT E Hetherington
Department of Zoology, Ohio State University, Columbus 43210 1293
J Comp Physiol A 163:43-52. 1988..Rather, response amplitude corresponded best with the absolute difference between shoulder and head motion...
- [Clinical evaluation after myocardial infarction. Its role, date and methods]J Machecourt
Clinique Cardiologique et Urgences Cardiologiques, CHU, Grenoble
Arch Mal Coeur Vaiss 85:789-98. 1992..angiography is the only investigation which allows assessment of the coronary circulation and is probably the best method of evaluating global and regional left ventricular function, two essential prognostic factors: on the other ..
- Three years clinical experience with intestinal transplantationK Abu-Elmagd
Pittsburgh Transplant Institute, University of Pittsburgh Medical Center, PA 15213
J Am Coll Surg 179:385-400. 1994..By the end of this time, the best survival rate (86 percent) was with the multivisceral procedure...
- [Evaluation of a new method for antifungal drugs susceptibility testing to yeasts]S Ishigaki
Department of Central Laboratory, Teikyo School of Medicine
Kansenshogaku Zasshi 74:221-30. 2000..However, the best agreement between the results for clinical isolates was seen with 5-FC (100% agreement [Within +/- 2 log2 dilutions]..
- Infantile scoliosis in Marfan syndromeP D Sponseller
Department of Orthopaedic Surgery, Johns Hopkins University, Baltimore, Maryland, USA
Spine (Phila Pa 1976) 22:509-16. 1997..Instrumentation without fusion was used in three patients for a mean of 3 years, with best results in one nonkyphotic curve. Nine patients underwent instrumented fusion at a mean age of 6...
- [The best in 2000 on arrhythmia]J Y Le Heuzey
Service de cardiologie, , 20, rue Leblanc, 75015 Paris
Arch Mal Coeur Vaiss 94:21-6. 2001....
- An investigation of ethnic differences in bone mineral, hip axis length, calcium metabolism and bone turnover between West African and Caucasian adults living in the United KingdomB Dibba
Medical Research Council Dunn Nutrition Unit, Cambridge, UK
Ann Hum Biol 26:229-42. 1999..Bone mineral content (BMC), bone mineral density (BMD) and BMC adjusted for bone area, body weight and height (size-adjusted BMC) were measured for the whole-body, ..
- In vivo and in vitro evidence of altered nitric oxide metabolism in the spontaneously diabetic, insulin-dependent BB/Edinburgh ratR M Lindsay
Metabolic Unit, Western General Hospitals NHS Trust, Edinburgh
Br J Pharmacol 120:1-6. 1997..in mesenteric arterial bed preparations from spontaneously diabetic, insulin-dependent and treated BB rats, the best animal model of insulin-dependent mellitus (IDDM) currently available...
- Gastric non-Hodgkin's lymphoma: analysis of 252 patients from a multicenter studyL Salvagno
Divisione di Oncologia Medica, Centro Oncologico Regionale, Padua
Tumori 85:113-21. 1999..most common site of primary extranodal non-Hodgkin's lymphoma (NHL) and no agreement has been reached so far on the best therapeutic approach...
- Training, experience and interest of general practitioners in travel medicine in New ZealandP A Leggat
School of Public Health and Tropical Medicine, James Cook University, Townsville, Queensland, Australia
J Travel Med 6:60-5. 1999..in travel medicine or related areas, interest in undertaking training in travel medicine and how training might be best delivered...
- [Long-term results after surgery of coarctation of the aorta in neonates and children]S Di Filippo
Service de Cardiologie C, , Lyon-Montchat
Arch Mal Coeur Vaiss 90:1723-8. 1997..prostaglandin E1 have considerably reduced the immediate mortality by enabling surgery to be undertaken under the best possible haemodynamic conditions...
- A systematic overview of chemotherapy effects in Hodgkin's diseaseL Brandt
Department of Oncology, University Hospital, Lund, Sweden
Acta Oncol 40:185-97. 2001..Several chemotherapy regimens containing four to eight drugs are effective in HD. The best regimen considering both antitumour activity and acute and late side-effects is not known...
- [The best in 2000 on arterial hypertension]H Milon
Service de cardiologie, , 103, Grande-Rue de la Croix-Rousse 69317 Lyon
Arch Mal Coeur Vaiss 94:7-12. 2001....
- [Hypertension--heart rate and cardiovascular risk]A Benetos
INSERM U337, 15, rue de l Ecole de Medecine, 75006 Paris
Arch Mal Coeur Vaiss 93:1371-6. 2000..The best known of these, the Framingham study, showed that an increased heart rate was associated with an increased ..
- A review of myelofibrosis in dogsW J Reagan
Purdue University, School of Veterinary Medicine, Department of Pathobiology, West Lafayette, Indiana 47907 1027
Toxicol Pathol 21:164-9. 1993..The proliferation of the bone marrow fibroblasts is not clonal in origin. To the best of this author's knowledge, this type of myelofibrosis has not been reported to occur naturally in the dog...
- A comparison between methods of identification and serotyping of encapsulated strains of Haemophilus influenzaeI S Taubitz
Zentralbl Bakteriol Mikrobiol Hyg A 270:83-97. 1988..With most methods best results were achieved by using cultures incubated at 37 degrees C for 6 h...
- [Possibilities of palliation in pancreatic cancer]F Di Costanzo
Dipartimento di Medicina Interna ed Oncologia, Azienda Ospedaliera Santa Maria, Terni, Italia
Tumori 85:S47-53. 1999..When chemotherapy was compared to best supportive care (BSC), the results demonstrated a survival gain...
- [The best of arterial hypertension in 1999]H Milon
Service de cardiologie, , Lyon
Arch Mal Coeur Vaiss 93:9-15. 2000....
- [Surgical treatment of medically refractory epilepsy in childhood]O C Snead
Bloorview Epilepsy Program, Department of Neurosurgery, University of Toronto and Division of Neurology, Toronto, Canada
No To Hattatsu 33:124-7. 2001Twenty five percent of children with epilepsy continue to seize despite best medical management and may be defined as medically refractory. Many children with medically refractory localization-related epilepsy, i.e...
- The generalist health care workforce: issues and goalsS A Wartman
Department of Internal Medicine, Mount Sinai Medical Center of Greater Miami, Miami Beach, FL 33140
J Gen Intern Med 9:S7-13. 1994The generalist health care workforce in the United States is best characterized as those practitioners who deliver primary care services...
- [The best of arrhythmias in 1999]E Aliot
Service de cardiologie, , Nancy
Arch Mal Coeur Vaiss 93:25-31. 2000..Finally, significant progress has been made in the field of genetics of cardiac arrhythmias, indicating that, in years to come, it will be possible to identify most of the genes responsible for conditions predisposing to arrhythmias...
- [Immediate delayed coronary angioplasty after intravenous thrombolysis in myocardial infarction. Prospective study]J L Bonnet
Service de cardiologie A, CHU Timone, Marseille
Arch Mal Coeur Vaiss 83:1375-9. 1990..plasminogen activator, association of the two thrombolytics) for acute myocardial infarction to determine the best time to perform percutaneous transluminal coronary angioplasty (PTCA)...
- Groin hernia surgery: a systematic reviewC M Cheek
The Royal College of Surgeons of England
Ann R Coll Surg Engl 80:S1-80. 1998..It is uncertain which method is the best in terms of safety and effectiveness.
- [The best in 2000 on echocardiography]A Cohen
Service de cardiologie, , 184, rue du Faubourg-Saint-Antoine, 75571 Paris
Arch Mal Coeur Vaiss 94:27-39. 2001....
- Aerobic fitness testing in patients with chronic low back pain: which test is best?H Wittink
New England Medical Center, Pain Management Clinic, Boston, MA 02111, USA
Spine (Phila Pa 1976) 25:1704-10. 2000..This is a randomized comparison of three exercise tests in a sample of 30 patients with chronic low back pain...
- Separation of paralytic shellfish poisoning toxins on Chromarods-SIII by thin-layer chromatography with the Iatroscan (mark 5) and flame thermionic detectionW M Indrasena
Canadian Institute of Fisheries Technology, Department of Food Science and Technology, DalTech, Dalhousie University, Halifax, Nova Scotia, Canada
J Chromatogr A 855:657-68. 1999..0 A (ampere) or above were found to yield the best results for the detection of PSP compounds. Increasing the detector current level to as high as 3...
- Bone mineralization and turnover in preterm infants at 8-12 years of age: the effect of early dietM S Fewtrell
MRC Human Nutrition Research (formerly Dunn Nutritional Laboratory, Cambridge, United Kingdom
J Bone Miner Res 14:810-20. 1999..hypotheses experimentally, we measured whole body and regional bone mineral content (BMC) and bone mineral density (BMD), using dual-energy X-ray absorptiometry and single-photon absorptiometry, and bone turnover at 8-12 years in 244 ..
- Oral disadvantage among dentate adultsG H Gilbert
Claude D. Pepper Center for Research on Oral Health in Aging, Gainesville, FL 32610-0416, USA
Community Dent Oral Epidemiol 25:301-13. 1997..Factor analysis suggested that oral disadvantage is best described as three factors: disadvantage due to (1) oral disease/tissue damage, (2) oral pain, and (3) oral ..
- Flow cytometry DNA analysis and prediction of loco-regional recurrences after mastectomy in breast cancerS B Ewers
Southern Swedish Breast Cancer Group, Department of Oncology, University Hospital, Lund
Acta Oncol 31:733-40. 1992..Such patients would best benefit from postoperative radiotherapy following modified radical mastectomy and axillary lymph node dissection...
- [Botulinum toxin as a treatment for infantile cerebral palsy]S I Pascual Pascual
, Hospital Infantil La Paz, Madrid,
Rev Neurol 25:1369-75. 1997..in 11-22%, and moderate-important with functional improvement in 40-78% of patients, being patient's evaluation the best and physiotherapist's one the worst. Spasticity improved 2 or more grades in Ashworth scale in 7/9 cases...
- Treatment of Vitamin D InsufficiencyKaren E Hansen; Fiscal Year: 2010..CaAb), secondary hyperparathyroidism (HPT), increased bone resorption and decreased bone mineral density (BMD) . Thus, experts agree that patients with vitamin D deficiency should receive vitamin D therapy [4-7]...
- Joint Determinants of Bone Density and CVD CalcificationBraxton Mitchell; Fiscal Year: 2004..Recent studies document that bone mineral density (BMD) is inversely correlated with severity of aortic and coronary artery calcification, markers of atherosclerosis...
- A Novel Long-Lived 41Ca Marker To Assess Bone Turnover For Breast Cancer PatientsSusanta Hui; Fiscal Year: 2007..The currently much-used method of monitoring bone mineral density (BMD) is neither sensitive to small changes in bone density, nor suitable for frequent assesments of bone density...
- Clinical Validation of BCTDAVID KOPPERDAHL; Fiscal Year: 2007..Due to limitations in areal BMD measures obtained from 2D DXA scans - which is the current clinical standard for diagnosis of osteoporosis - it has ..
- Depo-provera & BMD: Continuing ObservationsM Clark; Fiscal Year: 2005..The ongoing parent study is longitudinal, comparing changes in bone mineral density (BMD) every 3 months for 24 months between women newly initiating DMPA for contraception and women using no hormonal ..
- 3-D Visualization and Prediction of Spine FracturesElise F Morgan; Fiscal Year: 2010..Average measures of bone mineral density (BMD) explain only 50-70% of the variance in vertebral strength, a result that is not surprising given the heterogeneous ..
- DEPO PROVERA AND BONE MINERAL DENSITY IN ADOLESCENTSBarbara Cromer; Fiscal Year: 2003..Recent research in adults has suggested a negative effect of DMPA on bone mineral density (BMD)...
- FRACTURES IN OLDER WOMENSteven Cummings; Fiscal Year: 1993..Three examinations have yielded a comprehensive set of measurements that include bone mineral density (BMD), neuromuscular function, functional status, and other risk factors for fractures; follow-up over 2...
- FRACTURES IN OLDER WOMENKristine Ensrud; Fiscal Year: 1993..Three examinations have yielded a comprehensive set of measurements that include bone mineral density (BMD), neuromuscular function, functional status, and other risk factors for fractures; follow-up over 2...
- GENETIC AND DYNAMIC ANALYSES OF PEAK BONE DENSITY IN MICEWesley Beamer; Fiscal Year: 2007..and determine cellular actions of genes on mouse Chromosomes (Chr) 1 and 4 that regulate bone mineral density (BMD)...
- GENETIC AND DYNAMIC ANALYSES OF PEAK BONE DENSITY IN MICELeah Rae Donahue; Fiscal Year: 2009..and determine cellular actions of genes on mouse Chromosomes (Chr) 1 and 4 that regulate bone mineral density (BMD)...
- Nutritional and Hormonal Determinants of Peak Bone MassMadhusmita Misra; Fiscal Year: 2007..loss, however, is not well understood and no treatment has so far proven effective in treating low bone density (BMD) in adolescents with AN...
- FT-IR Microscopy of Mineral StructureAdele L Boskey; Fiscal Year: 2010..While reduced bone mineral density (BMD) relative to young individuals is routinely used clinically to predict fracture risk, BMD is not a strong predictor,..
- Cyclic Versus Daily Teriparatide on Bone Mass, Microstructure and StrengthRobert Lindsay; Fiscal Year: 2010..of teriparatide given cyclically (8 three month cycles) over 4 years with teriparatide given daily for 2 years on BMD of the spine and hip by DXA and QCT and BMD and microstructure of the radius and tibia assessed by high resolution ..
- Identification of Proteins Important for Male OsteoporosisHong Wen Deng; Fiscal Year: 2009..Male Osteoporosis Osteoporosis is a major public health problem, mainly characterized by low bone mineral density (BMD). Variation of BMD is largely genetically determined (heritability of > 60%)...
- Identification of Proteins Important for Male OsteoporosisHong Wen Deng; Fiscal Year: 2010..Male Osteoporosis Osteoporosis is a major public health problem, mainly characterized by low bone mineral density (BMD). Variation of BMD is largely genetically determined (heritability of >60%)...
- ROBUST AND POWERFUL TEST OF CANDIDATE GENES TO BONE MASSHong Wen Deng; Fiscal Year: 2010Osteoporosis is a major public health problem mainly characterized by low bone mineral density (BMD). BMD has a heritability >60%...
- ROBUST AND POWERFUL TEST OF CANDIDATE GENES TO BONE MASSHong Wen Deng; Fiscal Year: 2009Osteoporosis is a major public health problem mainly characterized by low bone mineral density (BMD). BMD has a heritability > 60%...
- Establishing the Precursors of Osteoporosis in ChildrenXiping Xu; Fiscal Year: 2009..bone mass as measured by DEXA, including bone mineral content (BMC), bone area (BA) and bone mineral density (BMD) in relation to a wide range of putative precursors of osteoporosis...
- Establishing the Precursors of Osteoporosis in ChildrenXiping Xu; Fiscal Year: 2007..bone mass as measured by DEXA, including bone mineral content (BMC), bone area (BA) and bone mineral density (BMD) in relation to a wide range of putative precursors of osteoporosis...
- Establishing the Precursors of Osteoporosis in ChildrenXiping Xu; Fiscal Year: 2010..bone mass as measured by DEXA, including bone mineral content (BMC), bone area (BA) and bone mineral density (BMD) in relation to a wide range of putative precursors of osteoporosis...
- GENETIC EPIDIMOLOGY OF OSTEOPOROSISXiping Xu; Fiscal Year: 2005..Using peripheral DXA (pDXA) technology to measure proximal radial BMD, a strong predictor for osteoporosis, this proposed investigation will screen 15,000 sib pairs aged 40-64 years in ..
- Epidemiology of Bone Loss in African MenJoseph M Zmuda; Fiscal Year: 2010..to continue our Tobago Bone Health Study (R01-AR049747), a unique population-based study of bone mineral density (BMD) in 2,424 black men aged e40 years...
- RISK FACTORS FOR VERTEBRAL FRACTURE AND BONE LOSSDouglas Kiel; Fiscal Year: 1993..The third objective is to measure shorter term changes in bone mineral density (BMD) of the hip and radius (assessed by single photon absorptiometry and dual energy X-ray absorptiometry) among very ..
- Activators of the Pyrophosphatase Activity of Alkaline PhosphataseJose Luis Millan; Fiscal Year: 2007..TNAP sufficiently high to be able to lower circulating PPi and OPN concentrations to enhance bone mineral density (BMD) in these animals...
- Early effects of PTH on the proximal femurFelicia Cosman; Fiscal Year: 2010..Teriparatide (TPTD), the aminoterminal fragment of parathyroid hormone, increases BMD and bone strength and reduces fracture incidence throughout the skeleton, but data confirming specific efficacy ..
- Effect of Chronic Proton Pump Inhibitor Therapy on Bone Mineral Density and BoneYu Xiao Yang; Fiscal Year: 2009..both calcium malabsorption and vitamin B12 deficiency are associated with reduced bone mineral density (BMD) and increased osteoporotic fracture risk...
- Effect of Chronic Proton Pump Inhibitor Therapy on Bone Mineral Density and BoneYu Xiao Yang; Fiscal Year: 2010..both calcium malabsorption and vitamin B12 deficiency are associated with reduced bone mineral density (BMD) and increased osteoporotic fracture risk...
- Recruiting activated endothellal progenitor cells to wounds by hyperoxia & SDF-1aOmaida C Velazquez; Fiscal Year: 2010..Bone marrow-derived endothelial progenitor cells (BMD EPC) contribute to wound healing since these progenitor/stem cells are the key cellular effectors of post-natal ..
- Recruiting activated endothellal progenitor cells to wounds by hyperoxia & SDF-1aOmaida Velazquez; Fiscal Year: 2009..Bone marrow-derived endothelial progenitor cells (BMD EPC) contribute to wound healing since these progenitor/stem cells are the key cellular effectors of post-natal ..
- THE TEMPORAL AND SPATIAL REGULATION OF BONE ACQUISITION BY SERUM IGF-1Shoshana Yakar; Fiscal Year: 2010..Human studies have demonstrated a relatively strong correlation between serum IGF-I and bone mineral density (BMD)...
- THE TEMPORAL AND SPATIAL REGULATION OF BONE ACQUISITION BY SERUM IGF-1Shoshana Yakar; Fiscal Year: 2009..Human studies have demonstrated a relatively strong correlation between serum IGF-I and bone mineral density (BMD)...
- X-Ray Scattering Bone DensitometryMIODRAG KRMAR; Fiscal Year: 2006..A new diagnostic technique of measuring bone mineral density (BMD) for diagnosis and monitoring the course of treatment (assessment) of osteoporosis and other bone diseases is ..
- LEAD EXPOSURE, GENETICS AND OSTEOPOROSIS EPIDEMIOLOGYSusan Korrick; Fiscal Year: 2002..evaluation of three major hypotheses: (1) Lead exposure is associated with declines in bone mineral density (BMD) and increases in bone turnover (defined by serum osteocalcin and urinary cross-linked N telopeptide of type I ..
- EFFECTS OF ANDROGENS, ESTROGENS, AND PTH ON BONEJoel Finkelstein; Fiscal Year: 2007..We have previously reported the effects of hypogonadism and sex steroid replacement on bone mineral density (BMD) in GnRH-deficient men, men with histories of delayed puberty, and men with adult-onset hypogonadism...