BDKRB2

Summary

Gene Symbol: BDKRB2
Description: bradykinin receptor B2
Alias: B2R, BK-2, BK2, BKR2, BRB2, B2 bradykinin receptor, BK-2 receptor
Species: human
Products:     BDKRB2

Top Publications

  1. Dhamrait S, Payne J, Li P, Jones A, Toor I, Cooper J, et al. Variation in bradykinin receptor genes increases the cardiovascular risk associated with hypertension. Eur Heart J. 2003;24:1672-80 pubmed
    ..These are the first reported human data to suggest a role for the B(1)R in human coronary vascular disease, and the first prospective study to demonstrate a similar role for the B(2)R. ..
  2. Fischer M, Lieb W, Marold D, Berthold M, Baessler A, Lowel H, et al. Lack of association of a 9 bp insertion/deletion polymorphism within the bradykinin 2 receptor gene with myocardial infarction. Clin Sci (Lond). 2004;107:505-11 pubmed
    ..These findings indicate that the 9 bp insertion/deletion polymorphism of the BK B2 receptor gene is neither related to the prevalence of MI nor to left ventricular function after MI. ..
  3. Fu Y, Katsuya T, Matsuo A, Yamamoto K, Akasaka H, Takami Y, et al. Relationship of bradykinin B2 receptor gene polymorphism with essential hypertension and left ventricular hypertrophy. Hypertens Res. 2004;27:933-8 pubmed
    ..It was recently reported that a polymorphism of the bradykinin B2 receptor gene (BDKRB2) is a genetic predisposing factor for hypertension and cardiovascular disease...
  4. Brechter A, Lerner U. Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression. Arthritis Rheum. 2007;56:910-23 pubmed
    ..The synergistic stimulation is dependent on NF-kappaB and MAP kinases. These mechanisms might help to explain the enhanced bone resorption associated with inflammatory disorders, including that in rheumatoid arthritis. ..
  5. Krankel N, Katare R, Siragusa M, Barcelos L, Campagnolo P, Mangialardi G, et al. Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential. Circ Res. 2008;103:1335-43 pubmed publisher
    ..Reduction of BK sensitivity in progenitor cells from cardiovascular disease patients might contribute to impaired neovascularization after ischemic complications. ..
  6. Niu W, Qi Y, Gao P, Zhu D. A meta-analysis of the bradykinin B2 receptor gene --58C/T polymorphism with hypertension. Clin Chim Acta. 2010;411:324-8 pubmed publisher
    Numerous studies have attempted to associate -58C/T polymorphism of bradykinin B2 receptor gene (BDKRB2) with hypertension, whereas results were often irreproducible...
  7. Ma J, Wang D, Ward D, Chen L, Dessai T, Chao J, et al. Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor. Genomics. 1994;23:362-9 pubmed
    The bradykinin B2 receptor (BDKRB2) has high affinity for the intact kinins, which mediate a wide spectrum of biological effects, including pain, inflammation, vasodilation, and smooth muscle contraction and relaxation...
  8. Fallo F, Mulatero P, Vettor R, Scarda A, Della Mea P, Morello F, et al. Bradykinin B2 receptor gene C-58T polymorphism and insulin resistance. A study on obese patients. Horm Metab Res. 2004;36:243-6 pubmed
    The bradykinin B2 receptor (B2R) gene is a candidate in the pathogenesis of insulin resistance, which often clusters with other abnormalities in metabolic syndrome...
  9. Hopkinson N, Eleftheriou K, Payne J, Nickol A, Hawe E, Moxham J, et al. +9/+9 Homozygosity of the bradykinin receptor gene polymorphism is associated with reduced fat-free mass in chronic obstructive pulmonary disease. Am J Clin Nutr. 2006;83:912-7 pubmed
    ..However, alterations in the activity at the BK(2)R do not seem to account for the previously identified association of quadriceps strength with ACE genotype. ..

More Information

Publications135 found, 100 shown here

  1. Bellucci F, Cucchi P, Catalani C, Giuliani S, Meini S, Maggi C. Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2 receptor antagonism in human synovial fibroblasts. Br J Pharmacol. 2009;158:1996-2004 pubmed
    ..Bradykinin via B2 receptors can participate in inflammatory events in synovitis. MEN16132 is a highly potent B2 receptor antagonist capable of blocking pro-inflammatory responses to BK evoked in human synoviocytes. ..
  2. Wang P, Koehle M, Rupert J. No association between alleles of the bradykinin receptor-B2 gene and acute mountain sickness. Exp Biol Med (Maywood). 2010;235:737-40 pubmed publisher
    ..the in/del polymorphism +9/-9 [rs5810761] and the single-nucleotide polymorphism C--58T [rs1799722]) of BDKRB2 (the gene encoding the bradykinin receptor B2) and susceptibility to AMS in an altitude-exposed Nepalese ..
  3. Bhupatiraju C, Patkar S, Pandharpurkar D, Joshi S, Tirunilai P. Association and interaction of -58C>T and ±9 bp polymorphisms of BDKRB2 gene causing susceptibility to essential hypertension. Clin Exp Hypertens. 2012;34:230-5 pubmed publisher
    ..Polymorphisms of bradykinin B2 receptor (BDKRB2) gene are reported to be predisposing factors for hypertension...
  4. Menke J, Borkowski J, Bierilo K, MacNeil T, Derrick A, Schneck K, et al. Expression cloning of a human B1 bradykinin receptor. J Biol Chem. 1994;269:21583-6 pubmed
    ..The amino acid sequence of the B1 bradykinin receptor is 36% identical to the amino acid sequence of the B2 bradykinin receptor. The cloned B1 bradykinin receptor expressed in mammalian cells exhibits high affinity binding for 3H-..
  5. Aoki S, Mukae S, Itoh S, Sato R, Nishio K, Iwata T, et al. The genetic factor in acute myocardial infarction with hypertension. Jpn Circ J. 2001;65:621-6 pubmed
    ..Genetic variations in the AngII and BK-B2 receptors could prove to be significant pathophysiological mechanisms affecting essential hypertension and AMI, and genetic differences appear to be a new risk factor for these conditions. ..
  6. Chachisvilis M, Zhang Y, Frangos J. G protein-coupled receptors sense fluid shear stress in endothelial cells. Proc Natl Acad Sci U S A. 2006;103:15463-8 pubmed
    ..Furthermore, because GPCRs are a major target of drug development, a detailed characterization of mechanochemical signaling via the GPCR pathway will be relevant for the development of new antiatherosclerosis drugs. ..
  7. Van Guilder G, Pretorius M, Luther J, Byrd J, Hill K, Gainer J, et al. Bradykinin type 2 receptor BE1 genotype influences bradykinin-dependent vasodilation during angiotensin-converting enzyme inhibition. Hypertension. 2008;51:454-9 pubmed publisher
    To test the hypothesis that the bradykinin receptor 2 (BDKRB2) BE1+9/-9 polymorphism affects vascular responses to bradykinin, we measured the effect of intra-arterial bradykinin on forearm blood flow and tissue-type plasminogen activator ..
  8. Kramarenko I, Bunni M, Morinelli T, Raymond J, Garnovskaya M. Identification of functional bradykinin B(2) receptors endogenously expressed in HEK293 cells. Biochem Pharmacol. 2009;77:269-76 pubmed publisher
    ..We conclude that HEK293 cells express endogenous functional BK B(2) receptors, which couple to the mobilization of intracellular Ca(2+), increases in ECAR and increases in ERK phosphorylation. ..
  9. Zhang W, Bhola N, Kalyankrishna S, Gooding W, Hunt J, Seethala R, et al. Kinin b2 receptor mediates induction of cyclooxygenase-2 and is overexpressed in head and neck squamous cell carcinomas. Mol Cancer Res. 2008;6:1946-56 pubmed publisher
    ..These effects were abolished by the B2 receptor (B2R) antagonist HOE140 but not by the B1 receptor (B1R) antagonist Lys-[Leu(8)]des-Arg(9)-bradykinin...
  10. Kammerer S, Braun A, Arnold N, Roscher A. The human bradykinin B2 receptor gene: full length cDNA, genomic organization and identification of the regulatory region. Biochem Biophys Res Commun. 1995;211:226-33 pubmed
    ..By testing different putative regulatory fragments in a luciferase reporter assay, a gene activating function of the 5' upstream region of exon 1 was demonstrated. ..
  11. Wang B, Dang A, Liu G. Genetic variation in the promoter region of the beta2 bradykinin receptor gene is associated with essential hypertension in a Chinese Han population. Hypertens Res. 2001;24:299-302 pubmed
    ..045) and allelic frequencies (p = 0.033). These results suggested that -58C allele of the human beta2 bradykinin receptor gene may be an independent risk factor for essential hypertension in the Chinese Han population. ..
  12. Asselbergs F, Williams S, Hebert P, Coffey C, Hillege H, Navis G, et al. Epistatic effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels. Genomics. 2007;89:362-9 pubmed
    ..These results support the idea that the interplay between the renin-angiotensin, bradykinin, and fibrinolytic systems might play an important role in t-PA and PAI-1 biology. ..
  13. Pretorius M, Gainer J, Van Guilder G, Coelho E, Luther J, Fong P, et al. The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance. Clin Pharmacol Ther. 2008;83:122-9 pubmed
    ..038) or during bradykinin (P=0.03). Increased SBP or vascular resistance may contribute to increased left ventricular mass reported previously in individuals with the BE1+9/+9 genotype. ..
  14. Powell S, Slynn G, Thomas C, Hopkins B, Briggs I, Graham A. Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14. Genomics. 1993;15:435-8 pubmed
    ..The human bradykinin B2 receptor gene has been mapped to chromosome 14 using PCR to specifically amplify DNA from somatic cell hybrids. ..
  15. Lee Y, Tsai J. Angiotensin-converting enzyme gene insertion/deletion, not bradykinin B2 receptor -58T/C gene polymorphism, associated with angiotensin-converting enzyme inhibitor-related cough in Chinese female patients with non-insulin-dependent diabetes mellitus. Metabolism. 2001;50:1346-50 pubmed
    ..In conclusion, our results indicate that Chinese diabetic female subjects are susceptible to ACEI-related cough, and this susceptibility may be genetically predetermined. ..
  16. Williams A, Dhamrait S, Wootton P, Day S, Hawe E, Payne J, et al. Bradykinin receptor gene variant and human physical performance. J Appl Physiol (1985). 2004;96:938-42 pubmed
  17. Milan A, Mulatero P, Williams T, Carra R, Schiavone D, Martuzzi R, et al. Bradykinin B2 receptor gene (-58T/C) polymorphism influences baroreflex sensitivity in never-treated hypertensive patients. J Hypertens. 2005;23:63-9 pubmed
    ..aim of this study was to investigate the effect of a common polymorphic variant of the bradykinin B2 receptor gene (B2R; -58T/C) on the autonomic regulation of baroreflex sensitivity (BRS) in 129 mild-moderate never-treated ..
  18. Saunders C, de Milander L, Hew Butler T, Xenophontos S, Cariolou M, Anastassiades L, et al. Dipsogenic genes associated with weight changes during Ironman Triathlons. Hum Mol Genet. 2006;15:2980-7 pubmed
    ..The aim of this study was to determine whether there were any associations between polymorphisms within the ACE, BDKRB2, NOS3 and/or 5-HTT genes with weight changes during the 2000 and 2001 226 km South African Ironman Triathlons...
  19. Bertram C, Baltic S, Misso N, Bhoola K, Foster P, Thompson P, et al. Expression of kinin B1 and B2 receptors in immature, monocyte-derived dendritic cells and bradykinin-mediated increase in intracellular Ca2+ and cell migration. J Leukoc Biol. 2007;81:1445-54 pubmed
    ..BK, which increases the migration of immature hMo-DC in vitro, may play an important role in the migration of immature DC in noninflammatory conditions and may also be involved in the recruitment of immature DC to sites of inflammation. ..
  20. Stadnicki A, Pastucha E, Nowaczyk G, Mazurek U, Plewka D, Machnik G, et al. Immunolocalization and expression of kinin B1R and B2R receptors in human inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2005;289:G361-6 pubmed
    ..Thus bradykinin receptors in IBD may reflect intestinal inflammation. Increased B(1)R gene and protein expression in active IBD provides a structural basis of the important role of bradykinin in chronic inflammation. ..
  21. Hansen J, Hansen J, Speerschneider T, Lyngsø C, Erikstrup N, Burstein E, et al. Lack of evidence for AT1R/B2R heterodimerization in COS-7, HEK293, and NIH3T3 cells: how common is the AT1R/B2R heterodimer?. J Biol Chem. 2009;284:1831-9 pubmed publisher
    ..2000) Nature 407, 94-98 ) that the angiotensin II type 1 receptor (AT1R) and the bradykinin B2 receptor (B2R) form constitutive heterodimers...
  22. Sestile C, Maraschin J, Gama V, Zangrossi H, Graeff F, Audi E. Panicolytic-like action of bradykinin in the dorsal periaqueductal gray through ?-opioid and B2-kinin receptors. Neuropharmacology. 2017;123:80-87 pubmed publisher
    ..escape performance in a dose-dependent way, and this panicolytic-like effect was blocked by the BK type 2 receptor (B2R) antagonist HOE-140, and by the selective MOR antagonist CTOP...
  23. Aoki S, Mukae S, Itoh S, Sato R, Nishio K, Ueda H, et al. Genetic background in patients with acute myocardial infarction. Jpn Heart J. 2001;42:15-28 pubmed
  24. Faussner A, Bauer A, Kalatskaya I, Schüssler S, Seidl C, Proud D, et al. The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B(1) and B(2) bradykinin receptors. FEBS J. 2005;272:129-40 pubmed
    ..g. via G protein activation) involved in the interaction between the receptor and receptor kinases. ..
  25. Cerrato B, Carretero O, Janic B, Grecco H, Gironacci M. Heteromerization Between the Bradykinin B2 Receptor and the Angiotensin-(1-7) Mas Receptor: Functional Consequences. Hypertension. 2016;68:1039-48 pubmed publisher
    Bradykinin B2 receptor (B2R) and angiotensin-(1-7) Mas receptor (MasR)-mediated effects are physiologically interconnected. The molecular basis for such cross talk is unknown...
  26. Sawant S, Snyman C, Bhoola K. Comparison of tissue kallikrein and kinin receptor expression in gastric ulcers and neoplasms. Int Immunopharmacol. 2001;1:2063-80 pubmed
    ..This is a first study that provides strong evidence for enhanced expression of TK in peptic ulceration and gastric malignancy, suggestive of a crucial role for serine proteases in cancer. ..
  27. Brugts J, De Maat M, Boersma E, Witteman J, van Duijn C, Uitterlinden A, et al. The rationale and design of the PERindopril GENEtic association study (PERGENE): a pharmacogenetic analysis of angiotensin-converting enzyme inhibitor therapy in patients with stable coronary artery disease. Cardiovasc Drugs Ther. 2009;23:171-81 pubmed publisher
  28. Woo S, Bang S, Chung M, Jin S, Kim Y, Lee S. Lack of association between ACE and bradykinin B2 receptor gene polymorphisms and ACE inhibitor-induced coughing in hypertensive Koreans. J Clin Pharm Ther. 2009;34:561-7 pubmed publisher
    ..We found no significant links between polymorphisms of the ACE gene or bradykinin B2 receptor gene with ACE inhibitor-induced coughing in hypertensive Koreans. But, the topic remains controversial and requires more study. ..
  29. Willets J, Brighton P, Windell L, Rana S, Nash C, Konje J. Bradykinin-activated contractile signalling pathways in human myometrial cells are differentially regulated by arrestin proteins. Mol Cell Endocrinol. 2015;407:57-66 pubmed publisher
    ..Bradykinin induced rapid, transient intracellular Ca(2+) increases that were inhibited following B2 receptor (B2R) antagonism...
  30. Wang Q, Cheng G, Wang X, Wang D, Yang Y, Chen K, et al. Genetic effects of BDKRB2 and KNG1 on deep venous thrombosis after orthopedic surgery and the potential mediator. Sci Rep. 2018;8:17332 pubmed publisher
    ..we aimed to investigate the potential association in the Han Chinese population between the polymorphisms of BDKRB2 and KNG1 and DVT after orthopedic surgery (DVTAOS)...
  31. Zhang J, Li N, Yang L, Xie H, Yang Y, Wang H, et al. Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation. Toxicology. 2019;415:37-48 pubmed publisher
    ..TCE sensitization significantly increased the expression of BK receptor (B2R) in the liver...
  32. Duchene J, Schanstra J, Cellier E, Bascands J, Girolami J. [30 years: Happy birthday, GPCR. The bradykinin B2 receptor: an alternative and antiproliferative pathway]. Nephrologie. 2002;23:39-41 pubmed
    ..Besides this alternative signalling pathway for the B2 receptor, a novel concept of GPCR signalling is described. ..
  33. Cui J, Melista E, Chazaro I, Zhang Y, Zhou X, Manolis A, et al. Sequence variation of bradykinin receptors B1 and B2 and association with hypertension. J Hypertens. 2005;23:55-62 pubmed
    ..variants in the complete genomic sequence of the two subtypes of bradykinin receptors: B1 (BDKRB1) and B2 (BDKRB2) and to examine the association of these variants with essential hypertension...
  34. Chen S, Zhang L, Xu R, Ti Y, Zhao Y, Zhou L, et al. BDKRB2 +9/-9 bp polymorphisms influence BDKRB2 expression levels and NO production in knee osteoarthritis. Exp Biol Med (Maywood). 2017;242:422-428 pubmed publisher
    The bradykinin B2 receptor (BDKRB2) plays a key role in the inflammation process of osteoarthritis...
  35. Yang W, Chang J, Hsu S, Li T, Cho D, Huang C, et al. Bradykinin enhances cell migration in human chondrosarcoma cells through BK receptor signaling pathways. J Cell Biochem. 2010;109:82-92 pubmed publisher
    ..Taken together, our results indicated that BK enhances the migration of chondrosarcoma cells by increasing alpha2beta1 integrin expression through the BK receptors/PLC/PKCdelta/NF-kappaB signal transduction pathway. ..
  36. Marketou M, Kontaraki J, Zacharis E, Parthenakis F, Maragkoudakis S, Gavras I, et al. Differential gene expression of bradykinin receptors 1 and 2 in peripheral monocytes from patients with essential hypertension. J Hum Hypertens. 2014;28:450-5 pubmed publisher
    Bradykinin participates in various hypertensive processes, exerted via its type 1 and type 2 receptors (BKR1 and BKR2)...
  37. Zhang P, Zhu Y, Wang L, Chen L, Zhou S. Mining candidate genes associated with powdery mildew resistance in cucumber via super-BSA by specific length amplified fragment (SLAF) sequencing. BMC Genomics. 2015;16:1058 pubmed publisher
    ..population comprising 251 F2 individuals was developed using H136 (female parent) as susceptible parent and BK2 (male parent) as resistance donor. After PMR test, total genomic DNA was prepared from each plant...
  38. Bertram C, Misso N, Fogel Petrovic M, Figueroa C, Foster P, Thompson P, et al. Expression of kinin receptors on eosinophils: comparison of asthmatic patients and healthy subjects. J Leukoc Biol. 2009;85:544-52 pubmed publisher
    ..Importantly, anti-inflammatory corticosteroids down-regulated the expression of the kinin B(1)R. ..
  39. Pinheiro A, Paramos de Carvalho D, Certal M, Costa C, Magalhães Cardoso M, Ferreirinha F, et al. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal. 2013;11:70 pubmed publisher
    ..Bradykinin induces ATP release from human subcutaneous fibroblasts via connexin and pannexin-1-containing hemichannels leading to [Ca2+]i mobilization through the cooperation of B2 and P2Y12 receptors. ..
  40. Wang L, Lin S, Zhang J, Tian T, Jin L, Ren A. Fetal DNA hypermethylation in tight junction pathway is associated with neural tube defects: A genome-wide DNA methylation analysis. Epigenetics. 2017;12:157-165 pubmed publisher
    ..Subsequently, differentially hypermethylated CpG sites in neural tissues from 6 genes (BDKRB2, CTNNA1, CYFIP2, MMP7, MYH2, and TIAM2) were confirmed in stage 2...
  41. Vidal M, Astroza A, Matus C, Ehrenfeld P, Pavicic F, Sanchez T, et al. Kinin B2 receptor-coupled signal transduction in human cultured keratinocytes. J Invest Dermatol. 2005;124:178-86 pubmed
    ..and since both processes are affected during wound healing, we have examined the consequence of kinin B2 receptors (B2R) activation in cultured human keratinocytes...
  42. Freitas S, Pereira A, Floriano M, Mill J, Krieger J. Insertion/deletion polymorphism of the bradykinin type 2 receptor gene influence diastolic blood pressure. J Hum Hypertens. 2009;23:553-5 pubmed publisher
    ..Our finding indicated that the -9 bp allele may contribute to hypertension because of increased diastolic pressure. ..
  43. Abd Alla J, Reeck K, Langer A, Streichert T, Quitterer U. Calreticulin enhances B2 bradykinin receptor maturation and heterodimerization. Biochem Biophys Res Commun. 2009;387:186-90 pubmed publisher
    ..Concomitantly, the B(2) receptor-mediated enhancement of AT(1)-stimulated signaling was reduced. Thus, calreticulin enhances B(2) receptor maturation and heterodimerization with AT(1). ..
  44. Talameh J, Misher A, Hoskins J. A capillary electrophoresis method for genotyping the 9-bp exon 1 insertion/deletion in BDKRB2. Pharmacogenomics. 2012;13:353-8 pubmed publisher
    To develop and apply a novel genotyping method for the 9-bp exon 1 insertion/deletion polymorphism in BDKRB2. DNA from 718 patients with heart failure was extracted using standard methods and a region containing exon 1 of BDKRB2 was ..
  45. Desposito D, Chollet C, Taveau C, Descamps V, Alhenc Gelas F, Roussel R, et al. Improvement of skin wound healing in diabetic mice by kinin B2 receptor blockade. Clin Sci (Lond). 2016;130:45-56 pubmed publisher
    ..Levels of Bdkrb1 (encoding B1R) and Bdkrb2 (encoding B2R) mRNAs increased 1-2-fold in healthy and wounded diabetic skin compared with in non-diabetic skin...
  46. Oliveira Paula G, Luizon M, Lacchini R, Fontana V, Silva P, Biagi C, et al. Gene-Gene Interactions Among PRKCA, NOS3 and BDKRB2 Polymorphisms Affect the Antihypertensive Effects of Enalapril. Basic Clin Pharmacol Toxicol. 2017;120:284-291 pubmed publisher
    ..dimensionality reduction was used to characterize interactions among PRKCA, NOS3 (nitric oxide synthase 3) and BDKRB2 (bradykinin receptor B2) polymorphisms...
  47. Kalatskaya I, Schüssler S, Blaukat A, Muller Esterl W, Jochum M, Proud D, et al. Mutation of tyrosine in the conserved NPXXY sequence leads to constitutive phosphorylation and internalization, but not signaling, of the human B2 bradykinin receptor. J Biol Chem. 2004;279:31268-76 pubmed
    ..The mutated receptor binds to, but does not activate, its cognate heterotrimeric G protein G(q/11), thereby limiting the extent of ligand-independent receptor internalization. ..
  48. Duchene J, Schanstra J, Pecher C, Pizard A, Susini C, Esteve J, et al. A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation. J Biol Chem. 2002;277:40375-83 pubmed
    ..These observations demonstrate that bradykinin inhibits cell proliferation by a novel mechanism involving a direct protein-protein interaction between a GPCR (the B2 receptor) and SHP-2. ..
  49. Jozwiak L, Drop A, Buraczynska K, Ksiazek P, Mierzicki P, Buraczynska M. Association of the human bradykinin B2 receptor gene with chronic renal failure. Mol Diagn. 2004;8:157-61 pubmed
    ..The B2-bradykinin receptor (B2R) mediates the majority of physiological actions of bradykinin...
  50. von Suesskind Schwendi M, Heigel E, Pfaehler S, Haneya A, Schmid C, Hirt S, et al. Protective function of pirfenidone and everolimus on the development of chronic allograft rejection after experimental lung transplantation. Histol Histopathol. 2016;31:793-805 pubmed publisher
    ..On POD 20, all groups showed severe acute rejection (ISHLT A3-4/B1R-B2R)...
  51. Yang C, Chen Y, Chi P, Lin C, Hsiao L. Resveratrol inhibits BK-induced COX-2 transcription by suppressing acetylation of AP-1 and NF-?B in human rheumatoid arthritis synovial fibroblasts. Biochem Pharmacol. 2017;132:77-91 pubmed publisher
    ..protein and mRNA expression associated with PGE2 synthesis, and promoter activity was mediated through B2R receptors, which were attenuated by selective B2R antagonist Hoe140 or transfection with B2R siRNA...
  52. Trujillo C, Negraes P, Schwindt T, Lameu C, Carromeu C, Muotri A, et al. Kinin-B2 receptor activity determines the differentiation fate of neural stem cells. J Biol Chem. 2012;287:44046-61 pubmed publisher
    ..Because pharmacological treatments did not affect cell viability and proliferation, we conclude that bradykinin-induced signaling provides a switch for neural fate determination and specification of neurotransmitter receptor expression. ..
  53. Marney A, Ma J, Luther J, Ikizler T, Brown N. Endogenous bradykinin contributes to increased plasminogen activator inhibitor 1 antigen following hemodialysis. J Am Soc Nephrol. 2009;20:2246-52 pubmed publisher
    ..Factors that increase the production of bradykinin or decrease its degradation may enhance the inflammatory response to hemodialysis. ..
  54. Cárdenas A, Campos J, Ehrenfeld P, Mezzano S, Ruiz Ortega M, Figueroa C, et al. Up-regulation of the kinin B2 receptor pathway modulates the TGF-β/Smad signaling cascade to reduce renal fibrosis induced by albumin. Peptides. 2015;73:7-19 pubmed publisher
    ..Since bradykinin and the kinin B2 receptor (B2R) belong to a renoprotective system with mechanisms still unclarified, we investigated its anti-fibrotic role in the ..
  55. Huang Z, Yu J, Toselli P, Bhawan J, Sudireddy V, Taylor L, et al. Angiotensin II type 1 and bradykinin B2 receptors expressed in early stage epithelial cells derived from human embryonic stem cells. J Cell Physiol. 2007;211:816-25 pubmed
    ..Our results demonstrate that human embryonic stem cells can be differentiated effectively into the epithelial lineage and that when differentiated express functional, signaling AT1 and BKB2 receptors. ..
  56. Kagimoto Y, Yamasaki K, Shimada Ohmori R, Nan L, Numata Y, Aiba S. Positive correlation of vanilloid receptor subtype1 and prostaglandin E2 expression with pain in leiomyomas. J Dermatol. 2017;44:690-694 pubmed publisher
    ..We immunohistochemiacally examined the expression of algoneic factors: serotonin, histamin, Substance P, PGE2, BDKRB2, VR1 and CGRP. We compared the pain area and expression of algoneic factors to reveal possible correlations...
  57. Liesmaa I, Leskinen H, Kokkonen J, Ruskoaho H, Kovanen P, Lindstedt K. Hypoxia-induced expression of bradykinin type-2 receptors in endothelial cells triggers NO production, cell migration, and angiogenesis. J Cell Physiol. 2009;221:359-66 pubmed publisher
    ..Our present results show that mild hypoxia triggers a temporal expression of functional BK-2Rs in human and rat endothelial cells and support a role for BK-2Rs in hypoxia-induced angiogenesis. ..
  58. da Cunha Morales Álvares A, Schwartz E, Amaral N, Trindade N, Pedrino G, Silva L, et al. Bowman-Birk protease inhibitor from Vigna unguiculata seeds enhances the action of bradykinin-related peptides. Molecules. 2014;19:17536-58 pubmed publisher
    ..Two synthetic Bk-related peptides, Bk1 and Bk2, were used to investigate the importance of additional C-terminal amino acid residues on serine protease activity...
  59. Terzuoli E, Morbidelli L, Nannelli G, Giachetti A, Donnini S, Ziche M. Involvement of Bradykinin B2 Receptor in Pathological Vascularization in Oxygen-Induced Retinopathy in Mice and Rabbit Cornea. Int J Mol Sci. 2018;19: pubmed publisher
    ..BK receptor 2 (B2R) signaling has been implicated in both pro-inflammatory and pro-angiogenic effects promoted by BK...
  60. Kusser B, Braun A, Praun M, Illi S, von Mutius E, Roscher A. Polymorphisms in the bradykinin B2 receptor gene and childhood asthma. Biol Chem. 2001;382:885-9 pubmed
    ..Polymorphisms with a potential functional relevance have been described in the B2 bradykinin receptor gene. Study of these polymorphisms in 77 children with asthma and 73 controls revealed no association...
  61. Bentley J, Asselbergs F, Coffey C, Hebert P, Moore J, Hillege H, et al. Cardiovascular risk associated with interactions among polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems. PLoS ONE. 2010;5:e12757 pubmed publisher
    ..012), BDKRB2 C181T & ACE I/D (p?=?0.016), BDKRB2 C58T & ACE I/D (p?=?0.025), BDKRB2 exon 1 I/D & AT1R A1166C (p?=?0...
  62. Valdés G, Acuña S, Munizaga A, Soto G, Figueroa C. Utero-placental cellular and nuclear expression of bradykinin B2 receptors in normal and preeclamptic pregnancies. Pregnancy Hypertens. 2016;6:30-7 pubmed publisher
    The bradykinin type 2 receptor (B2R), main effector of the pleiotropic kallikrein-kinin system (KKS), has been localized in the key sites related to placentation in human, rat and guinea pig utero-placental units...
  63. Severini C, Petrocchi Passeri P, Ciotti M, Florenzano F, Petrella C, Malerba F, et al. Nerve growth factor derivative NGF61/100 promotes outgrowth of primary sensory neurons with reduced signs of nociceptive sensitization. Neuropharmacology. 2017;117:134-148 pubmed publisher
    ..This effect of painless NGF is explained by the reduced up-regulation of BK receptor 2 (B2R), respect to control NGF61...
  64. Hopkinson N, Li K, Kehoe A, Humphries S, Roughton M, Moxham J, et al. Vitamin D receptor genotypes influence quadriceps strength in chronic obstructive pulmonary disease. Am J Clin Nutr. 2008;87:385-90 pubmed
    ..003). The FokI common variants in the VDR gene are associated with skeletal muscle strength in both patients and control subjects, whereas the BsmI polymorphism is associated with strength only in patients. ..
  65. Eggerickx D, Raspe E, Bertrand D, Vassart G, Parmentier M. Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene. Biochem Biophys Res Commun. 1992;187:1306-13 pubmed
    ..From our results, the existence of B3 receptors and of B2 subtypes appears questionable. ..
  66. Weiss J, Hesse C, Haefeli W. Rapid and reliable genotyping of the C181T polymorphism in the bradykinin B2 receptor gene. Clin Chem Lab Med. 2003;41:281-3 pubmed
    ..It allows the solid evaluation of large patient populations with the best time. ..
  67. Enquist J, Skröder C, Whistler J, Leeb Lundberg L. Kinins promote B2 receptor endocytosis and delay constitutive B1 receptor endocytosis. Mol Pharmacol. 2007;71:494-507 pubmed
    ..insult, kinins are released and many kinin responses, such as inflammatory pain, adapt from a B2 receptor (B2R) type in the acute phase to a B1 receptor (B1R) type in the chronic phase...
  68. Orchel J, Witek L, Kimsa M, Strzalka Mrozik B, Kimsa M, Olejek A, et al. Expression patterns of kinin-dependent genes in endometrial cancer. Int J Gynecol Cancer. 2012;22:937-44 pubmed publisher
    ..This will eventually help to improve treatment strategies for patients with endometrial cancer in the future. ..
  69. Sharif N, Xu S, Li L, Katoli P, Kelly C, Wang Y, et al. Protein expression, biochemical pharmacology of signal transduction, and relation to intraocular pressure modulation by bradykinin B? receptors in ciliary muscle. Mol Vis. 2013;19:1356-70 pubmed
    ..9±7.3% and 37.0±5.6% at 5 h and 8 h post-injection; n=7-10). These studies have provided evidence of a functional endogenously expressed B?-receptor system in the CM that appears to be involved in modulating IOP. ..
  70. Chen S, Zhang L, Xu R, Ti Y, Zhao Y, Zhou L, et al. TheBDKRB2 +9/-9 Polymorphisms Influence Pro-Inflammatory Cytokine Levels in Knee Osteoarthritis by Altering TLR-2 Expression: Clinical and in Vitro Studies. Cell Physiol Biochem. 2016;38:1245-56 pubmed publisher
    The bradykinin B2 receptor (BDKRB2) +9/-9 gene polymorphisms have been shown to be associated with the susceptibility and severity of osteoarthritis (OA); however, the underlying mechanisms are unclear...
  71. Wright J, Botha J, Naidoo S. Influence of the kallikrein-kinin system on prostate and breast tumour angiogenesis. Tumour Biol. 2008;29:130-6 pubmed publisher
    ..These findings indicate that the KKS may be one of the more important players in angiogenesis associated with prostate and breast tumours. ..
  72. Nokkari A, Mouhieddine T, Itani M, Abou Kheir W, Daoud G, Zhu R, et al. Characterization of the Kallikrein-Kinin System Post Chemical Neuronal Injury: An In Vitro Biochemical and Neuroproteomics Assessment. PLoS ONE. 2015;10:e0128601 pubmed publisher
    ..In this study, we investigated both the expression and the role of Bradykinin 1 and 2 receptors (B1R and B2R), in mediating neuronal injury under chemical neurotoxicity paradigm in PC12 cell lines...
  73. Mulatero P, Williams T, Milan A, Paglieri C, Rabbia F, Fallo F, et al. Blood pressure in patients with primary aldosteronism is influenced by bradykinin B(2) receptor and alpha-adducin gene polymorphisms. J Clin Endocrinol Metab. 2002;87:3337-43 pubmed
    ..0% of the systolic and diastolic blood pressure variance, respectively. These data suggest that genetic variants of alpha-adducin and the bradykinin B(2)-R influence the blood pressure levels in patients with primary aldosteronism. ..
  74. Jong Y, Dalemar L, Seehra K, Baenziger N. Bradykinin receptor modulation in cellular models of aging and Alzheimer's disease. Int Immunopharmacol. 2002;2:1833-40 pubmed
    ..This Abeta-rich environment may serve to foster the signal transduction mechanism that generates I and L BK B2 receptors. ..
  75. Ariza A, Bobadilla N, Halhali A. [Endothelin 1 and angiotensin II in preeeclampsia]. Rev Invest Clin. 2007;59:48-56 pubmed
    ..High ET-1 levels, the presence of AT1/B2 receptor heterodimers and increased AT1-AA are involved, at least in part, in the hypertensive and oxidative stress states in PE. ..
  76. Kopkan L, Husková Z, Jíchová Å, ÄŒervenková L, ÄŒervenka L, Saifudeen Z, et al. Conditional knockout of collecting duct bradykinin B2 receptors exacerbates angiotensin II-induced hypertension during high salt intake. Clin Exp Hypertens. 2016;38:1-9 pubmed publisher
    ..To this end, we used a Cre-Lox recombination strategy to generate mice lacking Bdkrb2 gene for B2R in the collecting duct (Hoxb7-Cre(tg/+):Bdkrb2(flox/flox))...
  77. Taranta A, Gianviti A, Palma A, De Luca V, Mannucci L, Procaccino M, et al. Genetic risk factors in typical haemolytic uraemic syndrome. Nephrol Dial Transplant. 2009;24:1851-7 pubmed publisher
    ..09-0.83) (P < 0.02). These results highlight the role of glycoprotein 1balpha in the physiopathology of typical forms of HUS and show that the genetic background plays a role in the susceptibility and severity of the disease. ..
  78. Souza P, Brechter A, Reis R, Costa C, Lundberg P, Lerner U. IL-4 and IL-13 inhibit IL-1? and TNF-? induced kinin B1 and B2 receptors through a STAT6-dependent mechanism. Br J Pharmacol. 2013;169:400-12 pubmed publisher
  79. Moyes A, Gray G, Denison F. Bradykinin B1 receptor-mediated vasodilation is impaired in myometrial arteries from women with pre-eclampsia. Hypertens Pregnancy. 2014;33:177-90 pubmed publisher
    ..Receptor expression and localisation was unaltered in pre-eclampsia. Here, we demonstrate a novel B1 receptor-mediated vasodilatation in healthy myometrial vessels that is absent in pre-eclampsia. ..
  80. Ricciardolo F, Petecchia L, Sorbello V, Di Stefano A, Usai C, Massaglia G, et al. Bradykinin B2 receptor expression in the bronchial mucosa of allergic asthmatics: the role of NF-kB. Clin Exp Allergy. 2016;46:428-38 pubmed publisher
    ..Nuclear factor-kappa B (NF-kB) is potentially involved in BK B2 receptor (B2R) regulation...
  81. Mukae S, Itoh S, Aoki S, Iwata T, Nishio K, Sato R, et al. Association of polymorphisms of the renin-angiotensin system and bradykinin B2 receptor with ACE-inhibitor-related cough. J Hum Hypertens. 2002;16:857-63 pubmed
  82. Tazon Vega B, Vilardell M, Pérez Oller L, Ars E, Ruiz P, Devuyst O, et al. Study of candidate genes affecting the progression of renal disease in autosomal dominant polycystic kidney disease type 1. Nephrol Dial Transplant. 2007;22:1567-77 pubmed
    ..candidate genes (and polymorphisms) studied were the following: NOS3 (T-786C and E298D), BDKRB1 (-699 G > C), BDKRB2 (R14C), TGFB1 (-509 C > T, R25P and L10P), ACE (I/D), EGFR (IVS1CA) and PKD2 (-9780 G > A, -718 A > G and ..
  83. Saxena P, Shaw O, Misso N, Naran A, Shehatha J, Newman M, et al. Remote ischemic preconditioning stimulus decreases the expression of kinin receptors in human neutrophils. J Surg Res. 2011;171:311-6 pubmed publisher
    ..Reduction in kinin surface receptors suggests internalization of receptors and is consistent with the concepts of kinin receptor activation and their role in RIPC. ..
  84. Chen S, Zhou Y, Li J, Shan L, Fan Q. The effect of bradykinin B2 receptor polymorphisms on the susceptibility and severity of osteoarthritis in a Chinese cohort. J Biomed Biotechnol. 2012;2012:597637 pubmed publisher
    The B2-bradykinin receptor (BDKRB2) has been reported to associate with onset and development of Osteoarthritis (OA); however, the role of BDKRB2 genetic polymorphisms in OA remains unknown...
  85. Bakir N, Bozkuş H, Koldemir Gündüz M, Çağatay P, Taşkın M, Süsleyici Duman B. The relationship of Bradykinin B₂ receptor gene variation with obesity, hypertension and lipid variables in obese patients. Acta Med Acad. 2014;43:144-54 pubmed publisher
  86. Catalioto R, Valenti C, Maggi C, Giuliani S. Enhanced Ca(2+) response and stimulation of prostaglandin release by the bradykinin B2 receptor in human retinal pigment epithelial cells primed with proinflammatory cytokines. Biochem Pharmacol. 2015;97:189-202 pubmed publisher
    ..In conclusion, overall data revealed a cross-talk between the kinin B2 receptor and cytokines in human RPE in promoting inflammation, a key feature in retinal pathologies including diabetic retinopathy and macular edema. ..
  87. Michineau S, Alhenc Gelas F, Rajerison R. Human bradykinin B2 receptor sialylation and N-glycosylation participate with disulfide bonding in surface receptor dimerization. Biochemistry. 2006;45:2699-707 pubmed
    ..Importantly, receptor sialylation and N-glycosylation participate with disulfide bonding in the stabilization of the cell surface human B2 receptor dimers. ..
  88. Charest Morin X, Fortin S, Lodge R, Roy C, Gera L, Gaudreault R, et al. Inhibitory effects of cytoskeleton disrupting drugs and GDP-locked Rab mutants on bradykinin B? receptor cycling. Pharmacol Res. 2013;71:44-52 pubmed publisher
    ..We assessed the effect of drugs that affect the cytoskeleton on B2R cycling...
  89. Liu Y, Liu J, Li M, Dai S, Liang J, Ji W. The effect of kinin B1 receptor on chronic itching sensitization. Mol Pain. 2015;11:70 pubmed publisher
    ..Preventive treatment with the B1R antagonist R892 significantly suppressed spontaneous scratching, while the B2R selective antagonist did not...
  90. Chen Y, Yu Y, Sun S, Wang Z, Liu P, Liu S, et al. Bradykinin promotes migration and invasion of hepatocellular carcinoma cells through TRPM7 and MMP2. Exp Cell Res. 2016;349:68-76 pubmed publisher
    ..Src was critical in the process of MMP2 secretion and invadopodia formation. The heat map showed that BDKRB2, TRPM7 and MMP2 had higher overexpression proportions in 25 HCC cell lines...