BCL6

Summary

Gene Symbol: BCL6
Description: B cell CLL/lymphoma 6
Alias: BCL5, BCL6A, LAZ3, ZBTB27, ZNF51, B-cell lymphoma 6 protein, B-cell lymphoma 5 protein, B-cell lymphoma 6 protein transcript, BCL-5, BCL-6, cys-his2 zinc finger transcription factor, lymphoma-associated zinc finger gene on chromosome 3, protein LAZ-3, zinc finger and BTB domain-containing protein 27, zinc finger protein 51, zinc finger transcription factor BCL6S
Species: human
Products:     BCL6

Top Publications

  1. Fujita N, Jaye D, Geigerman C, Akyildiz A, Mooney M, Boss J, et al. MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. Cell. 2004;119:75-86 pubmed
  2. Baron B, Anastasi J, Thirman M, Furukawa Y, Fears S, Kim D, et al. The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis. Proc Natl Acad Sci U S A. 2002;99:2860-5 pubmed
    b>BCL6, a gene on chromosome 3 band q27, encodes a Kruppel-type zinc finger transcriptional repressor. Rearrangements of this gene are frequent in various kinds of lymphomas, particularly of the large-cell B-cell type...
  3. Basso K, Saito M, Sumazin P, Margolin A, Wang K, Lim W, et al. Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells. Blood. 2010;115:975-84 pubmed publisher
    b>BCL6 is a transcriptional repressor required for mature B-cell germinal center (GC) formation and implicated in lymphomagenesis...
  4. Chang C, Ye B, Chaganti R, Dalla Favera R. BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc Natl Acad Sci U S A. 1996;93:6947-52 pubmed
    ..of diffuse large cell lymphoma are associated with chromosomal translocations that deregulate the expression of the BCL6 gene by juxtaposing heterologous promoters to the BCL-6 coding domain...
  5. Lemercier C, Brocard M, Puvion Dutilleul F, Kao H, Albagli O, Khochbin S. Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor. J Biol Chem. 2002;277:22045-52 pubmed
    b>BCL6 is a member of the POZ/zinc finger (POK) family involved in survival and/or differentiation of a number of cell types and in B cell lymphoma upon chromosomal alteration...
  6. Wlodarska I, Nooyen P, Maes B, Martin Subero J, Siebert R, Pauwels P, et al. Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma. Blood. 2003;101:706-10 pubmed
    We studied the genomic status of BCL6 in 23 cases of nodular lymphocyte predominance Hodgkin lymphoma (NLPHL) and 40 cases of classical Hodgkin lymphoma (cHL), using dual-color interphase fluorescence in situ hybridization (FISH)...
  7. Ye B, Cattoretti G, Shen Q, Zhang J, Hawe N, de Waard R, et al. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet. 1997;16:161-70 pubmed
    ..Altered expression of BCL-6 in lymphoma represents a deregulation of the pathway normally leading to B cell proliferation and germinal centre formation. ..
  8. Tran T, Utama F, Lin J, Yang N, Sjolund A, Ryder A, et al. Prolactin inhibits BCL6 expression in breast cancer through a Stat5a-dependent mechanism. Cancer Res. 2010;70:1711-21 pubmed publisher
    b>BCL6 is a transcriptional repressor that recognizes DNA target sequences similar to those recognized by signal transducer and activator of transcriptions 5 (Stat5)...
  9. Ye H, Remstein E, Bacon C, Nicholson A, Dogan A, Du M. Chromosomal translocations involving BCL6 in MALT lymphoma. Haematologica. 2008;93:145-6 pubmed publisher
    Chromosomal translocations involving BCL6 were detected in 7 out of 392 cases of MALT lymphoma by interphase fluorescence in situ hybridisation with a BCL6 break-apart probe...

More Information

Publications67

  1. Kinugasa Y, Hieda M, Hori M, Higashiyama S. The carboxyl-terminal fragment of pro-HB-EGF reverses Bcl6-mediated gene repression. J Biol Chem. 2007;282:14797-806 pubmed
    ..Immunoprecipitation showed that HB-EGF-CTF can associate with Bcl6, a transcriptional repressor in mammalian cells...
  2. Phan R, Saito M, Basso K, Niu H, Dalla Favera R. BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells. Nat Immunol. 2005;6:1054-60 pubmed
    The BCL6 proto-oncogene encodes a transcriptional repressor that is required for germinal center formation and has been linked to lymphomagenesis...
  3. Bereshchenko O, Gu W, Dalla Favera R. Acetylation inactivates the transcriptional repressor BCL6. Nat Genet. 2002;32:606-13 pubmed
    The proto-oncogene BCL6 encodes a BTB/POZ-zinc finger transcriptional repressor that is necessary for germinal-center formation and has been implicated in the pathogenesis of B-cell lymphomas...
  4. Niu H, Ye B, Dalla Favera R. Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor. Genes Dev. 1998;12:1953-61 pubmed
    ..This signaling pathway may be crucial for the control of B-cell differentiation and antibody response and has implications for the regulation of other POZ/zinc finger transcription factors in other tissues. ..
  5. Hurtz C, Hatzi K, Cerchietti L, Braig M, Park E, Kim Y, et al. BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. J Exp Med. 2011;208:2163-74 pubmed publisher
    ..Here, we identified the BCL6 protooncogene as a critical effector downstream of FoxO in self-renewal signaling of CML-initiating cells...
  6. Migliazza A, Martinotti S, Chen W, Fusco C, Ye B, Knowles D, et al. Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma. Proc Natl Acad Sci U S A. 1995;92:12520-4 pubmed
    The BCL6 gene encodes a zinc-finger transcription factor and is altered by chromosomal arrangements in its 5' noncoding region in approximately 30% of diffuse large-cell lymphoma (DLCL)...
  7. Batlle A, Papadopoulou V, Gomes A, Willimott S, Melo J, Naresh K, et al. CD40 and B-cell receptor signalling induce MAPK family members that can either induce or repress Bcl-6 expression. Mol Immunol. 2009;46:1727-35 pubmed publisher
    ..We demonstrate for the first time that p38 induces Bcl-6 transcription, but increased protein expression occurs only when the strong pathways repressing Bcl-6 are not activated. ..
  8. Flenghi L, Ye B, Fizzotti M, Bigerna B, Cattoretti G, Venturi S, et al. A specific monoclonal antibody (PG-B6) detects expression of the BCL-6 protein in germinal center B cells. Am J Pathol. 1995;147:405-11 pubmed
    ..These findings indicate that BCL-6 expression is specifically regulated during B lymphocyte development and suggest that BCL-6 may play a role during B cell differentiation in the germinal center. ..
  9. Jardin F, Ruminy P, Bastard C, Tilly H. The BCL6 proto-oncogene: a leading role during germinal center development and lymphomagenesis. Pathol Biol (Paris). 2007;55:73-83 pubmed
    The BCL6 proto-oncogene encodes a nuclear transcriptional repressor, with pivotal roles in germinal center (GC) formation and regulation of lymphocyte function, differentiation, and survival...
  10. Niu H. The proto-oncogene BCL-6 in normal and malignant B cell development. Hematol Oncol. 2002;20:155-66 pubmed
    ..This suggests that deregulated expression of BCL-6 may contribute to lymphomagenesis. ..
  11. Ci W, Polo J, Cerchietti L, Shaknovich R, Wang L, Yang S, et al. The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL. Blood. 2009;113:5536-48 pubmed publisher
    The BCL6 transcriptional repressor is required for development of germinal center (GC) B cells and when expressed constitutively causes diffuse large B-cell lymphomas (DLBCLs)...
  12. Baron B, Nucifora G, McCabe N, Espinosa R, Le Beau M, McKeithan T. Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas. Proc Natl Acad Sci U S A. 1993;90:5262-6 pubmed
    ..We propose the name BCL6 (B-cell lymphoma 6) for this gene, since it is likely to play a role in the pathogenesis of certain B-cell ..
  13. Gearhart M, Corcoran C, Wamstad J, Bardwell V. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. Mol Cell Biol. 2006;26:6880-9 pubmed
    The corepressor BCOR potentiates transcriptional repression by the proto-oncoprotein BCL6 and suppresses the transcriptional activity of a common mixed-lineage leukemia fusion partner, AF9...
  14. Pasqualucci L, Migliazza A, Basso K, Houldsworth J, Chaganti R, Dalla Favera R. Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma. Blood. 2003;101:2914-23 pubmed
    The BCL6 proto-oncogene encodes a transcriptional repressor whose expression is deregulated by chromosomal translocations in approximately 40% of diffuse large B-cell lymphomas (DLBCLs)...
  15. Ye B, Lista F, Lo Coco F, Knowles D, Offit K, Chaganti R, et al. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science. 1993;262:747-50 pubmed
    ..Thus, BCL-6 may be a proto-oncogene specifically involved in the pathogenesis of DLCL. ..
  16. Fernandez De Mattos S, Essafi A, Soeiro I, Pietersen A, Birkenkamp K, Edwards C, et al. FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism. Mol Cell Biol. 2004;24:10058-71 pubmed
    ..by STI571 results in down-regulation of cyclin D2 expression, activation of FoxO3a activity, and up-regulation of BCL6 expression...
  17. Saito Y, Liang G, Egger G, Friedman J, Chuang J, Coetzee G, et al. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell. 2006;9:435-43 pubmed
    ..In addition, the proto-oncogene BCL6, a potential target of miR-127, was translationally downregulated after treatment...
  18. Sato T, Tran T, Peck A, Girondo M, Liu C, Goodman C, et al. Prolactin suppresses a progestin-induced CK5-positive cell population in luminal breast cancer through inhibition of progestin-driven BCL6 expression. Oncogene. 2014;33:2215-24 pubmed publisher
    ..Pg-induction of CK5 was preceded by marked upregulation of BCL6, an oncogene and transcriptional repressor critical for the maintenance of leukemia-initiating cells...
  19. Shvarts A, Brummelkamp T, Scheeren F, Koh E, Daley G, Spits H, et al. A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling. Genes Dev. 2002;16:681-6 pubmed
    ..Using retroviral cDNA expression libraries, we identify BCL6 as a potent inhibitor of senescence...
  20. Hirata Y, Ogasawara N, Sasaki M, Mizushima T, Shimura T, Mizoshita T, et al. BCL6 degradation caused by the interaction with the C-terminus of pro-HB-EGF induces cyclin D2 expression in gastric cancers. Br J Cancer. 2009;100:1320-9 pubmed publisher
    b>BCL6 is a transcriptional repressor that has important functions in lymphocyte differentiation and lymphomagenesis, but there have been no reports of BCL6 expression in gastric cancers...
  21. Dhordain P, Lin R, Quief S, Lantoine D, Kerckaert J, Evans R, et al. The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression. Nucleic Acids Res. 1998;26:4645-51 pubmed
    ..Recently, we reported that SMRT also directly associates with LAZ3(BCL-6), a POZ/Zn finger transcriptional repressor involvedin the pathogenesis of non-Hodgkin lymphomas...
  22. Mendez L, Polo J, Yu J, Krupski M, Ding B, Melnick A, et al. CtBP is an essential corepressor for BCL6 autoregulation. Mol Cell Biol. 2008;28:2175-86 pubmed publisher
    The transcription repressor BCL6 plays an essential role in the formation and function of germinal centers (GCs)...
  23. Katzenberger T, Ott G, Klein T, Kalla J, Muller Hermelink H, Ott M. Cytogenetic alterations affecting BCL6 are predominantly found in follicular lymphomas grade 3B with a diffuse large B-cell component. Am J Pathol. 2004;165:481-90 pubmed
    ..To clarify the prevalence of BCL6 and BCL2 rearrangements in FL and diffuse large B-cell lymphomas (DLBLs), we performed a large scale bicolor ..
  24. Chen Y, Hu X, Liang A, Au W, So C, Wong M, et al. High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6-deregulating mutations, in gastric lymphoma. Blood. 2006;108:2373-83 pubmed
    To investigate the role of BCL6 in the pathogenesis of gastric lymphoma, we analyzed the BCL6 promoter region for BCL6 translocations, somatic hypermutations, and deregulating mutations in 43 gastric lymphomas, including 4 extranodal ..
  25. Polo J, Juszczynski P, Monti S, Cerchietti L, Ye K, Greally J, et al. Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas. Proc Natl Acad Sci U S A. 2007;104:3207-12 pubmed
    Diffuse large B cell lymphomas (DLBCLs) often express BCL6, a transcriptional repressor required for the formation of normal germinal centers...
  26. Cattoretti G, Chang C, Cechova K, Zhang J, Ye B, Falini B, et al. BCL-6 protein is expressed in germinal-center B cells. Blood. 1995;86:45-53 pubmed
    ..Because DLCL derive from germinal-center B cells, deregulated BCL-6 expression may contribute to lymphomagenesis by preventing postgerminal center differentiation. ..
  27. Phan R, Dalla Favera R. The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature. 2004;432:635-9 pubmed
    The human proto-oncogene BCL6 encodes a BTB/POZ-zinc-finger transcriptional repressor that is necessary for germinal-centre formation and is implicated in the pathogenesis of B-cell lymphoma...
  28. Shen H, Peters A, Baron B, Zhu X, Storb U. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science. 1998;280:1750-2 pubmed
    ..Significant mutations were not observed in c-MYC, S14, or alpha-fetoprotein (AFP) genes, but BCL-6 was highly mutated in a large proportion of memory B cells of normal individuals. The mutation pattern was similar to that of Ig genes. ..
  29. Wong C, Privalsky M. Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6. J Biol Chem. 1998;273:27695-702 pubmed
    ..Our results demonstrate that otherwise similar transcription factors can differ notably in their interactions with the corepressor machinery. ..
  30. Miles R, Crockett D, Lim M, Elenitoba Johnson K. Analysis of BCL6-interacting proteins by tandem mass spectrometry. Mol Cell Proteomics. 2005;4:1898-909 pubmed
    B-cell lymphoma 6 (BCL6) is a 95-kDa nuclear phosphoprotein and member of the Pox virus zinc finger/bric-a-brac, tramtrack, broad complex (POZ/BTB) family of transcription factors...
  31. Walker S, Nelson E, Yeh J, Pinello L, Yuan G, Frank D. STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6. Mol Cell Biol. 2013;33:2879-90 pubmed publisher
    ..Although STAT3 and STAT5 are structurally related, they can have opposite effects on key genes, including BCL6. BCL6, a transcriptional repressor, has been shown to be oncogenic in diffuse large B cell lymphoma...
  32. Pasqualucci L, Bereshchenko O, Bereschenko O, Niu H, Klein U, Basso K, et al. Molecular pathogenesis of non-Hodgkin's lymphoma: the role of Bcl-6. Leuk Lymphoma. 2003;44 Suppl 3:S5-12 pubmed
    ..These studies also indicate a novel mechanism by which acetylation promotes transcription, not only by modifying histones and activating transcriptional activators, but also by inhibiting transcriptional repressors. ..
  33. Lossos I, Akasaka T, Martinez Climent J, Siebert R, Levy R. The BCL6 gene in B-cell lymphomas with 3q27 translocations is expressed mainly from the rearranged allele irrespective of the partner gene. Leukemia. 2003;17:1390-7 pubmed
    The BCL6 gene, which functions as a transcription repressor, is the target of multiple chromosomal translocations in non-Hodgkin's lymphomas (NHL)...
  34. Pinto A, André S, Silva G, Vieira S, Santos A, Dias S, et al. BCL-6 oncoprotein in breast cancer: loss of expression in disease progression. Pathobiology. 2009;76:235-42 pubmed publisher
    ..The results strongly suggest the loss of BCL-6 expression in breast cancer progression, which might be related with methylation status alterations of still unknown partner gene(s). ..
  35. Horn H, Ziepert M, Becher C, Barth T, Bernd H, Feller A, et al. MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma. Blood. 2013;121:2253-63 pubmed publisher
    ..We investigated the prognostic relevance of MYC-, BCL2- and BCL6-rearrangements and protein expression in a prospective randomized trial...
  36. Ranuncolo S, Polo J, Dierov J, Singer M, Kuo T, Greally J, et al. Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR. Nat Immunol. 2007;8:705-14 pubmed
    ..Our data demonstrate a transcriptional regulatory loop whereby Bcl-6 mediates the centroblast phenotype through transient silencing of ATR. ..
  37. Díaz Alderete A, Doval A, Camacho F, Verde L, Sabin P, Arranz Saez R, et al. Frequency of BCL2 and BCL6 translocations in follicular lymphoma: relation with histological and clinical features. Leuk Lymphoma. 2008;49:95-101 pubmed publisher
    Follicular lymphomas (FLs) usually carry BCL2 translocations although BCL6 translocations are also present...
  38. Onizuka T, Moriyama M, Yamochi T, Kuroda T, Kazama A, Kanazawa N, et al. BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts. Blood. 1995;86:28-37 pubmed
    ..These results suggest that the BCL-6 protein, expressed in B cells of the germinal centers which are important in the maturation of immune responses, may play some physiological role(s) in the germinal center B cells. ..
  39. Iqbal J, Greiner T, Patel K, Dave B, Smith L, Ji J, et al. Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma. Leukemia. 2007;21:2332-43 pubmed
    ..The BCL6 gene is often translocated and/or mutated in DLBCL...
  40. Polo J, Dell Oso T, Ranuncolo S, Cerchietti L, Beck D, Da Silva G, et al. Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. Nat Med. 2004;10:1329-35 pubmed
    The BTB/POZ transcriptional repressor and candidate oncogene BCL6 is frequently misregulated in B-cell lymphomas...
  41. Dhordain P, Albagli O, Lin R, Ansieau S, Quief S, Leutz A, et al. Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein. Proc Natl Acad Sci U S A. 1997;94:10762-7 pubmed
    The LAZ3/BCL6 (lymphoma-associated zinc finger 3/B cell lymphomas 6) gene frequently is altered in non-Hodgkin lymphomas...
  42. Saito M, Gao J, Basso K, Kitagawa Y, Smith P, Bhagat G, et al. A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma. Cancer Cell. 2007;12:280-92 pubmed
    The BCL6 proto-oncogene encodes a transcriptional repressor necessary for the development of germinal centers (GCs) and directly implicated in lymphomagenesis...
  43. Ritz O, Rommel K, Dorsch K, Kelsch E, Melzner J, Buck M, et al. STAT6-mediated BCL6 repression in primary mediastinal B-cell lymphoma (PMBL). Oncotarget. 2013;4:1093-102 pubmed
    ..pSTAT6 is only expressed in a sub-population of lymphoma cells in a pattern that is reminiscent of that of the BCL6 oncogene...
  44. Kerckaert J, Deweindt C, Tilly H, Quief S, Lecocq G, Bastard C. LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas. Nat Genet. 1993;5:66-70 pubmed
    ..The gene (LAZ3) encodes a 79 kDa protein containing six zinc-finger motifs and sharing amino-terminal homology with several ..
  45. Miki T, Kawamata N, Hirosawa S, Aoki N. Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Krüppel-like zinc-finger protein. Blood. 1994;83:26-32 pubmed
    ..A part of the sequence was essentially identical to that of a genomic fragment, ZNF51, previously reported to be located at 3qter...
  46. Dent A, Shaffer A, Yu X, Allman D, Staudt L. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science. 1997;276:589-92 pubmed
    ..Thus, dysregulation of STAT-responsive genes may underlie the inflammatory disease in BCL-6-deficient mice and participate in lymphoid malignancies. ..
  47. Duan S, Cermak L, Pagan J, Rossi M, Martinengo C, di Celle P, et al. FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. Nature. 2012;481:90-3 pubmed publisher
    b>BCL6 is the product of a proto-oncogene implicated in the pathogenesis of human B-cell lymphomas...
  48. Deltour S, Guerardel C, Leprince D. Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B. Proc Natl Acad Sci U S A. 1999;96:14831-6 pubmed
    ..Taken together, our studies show that the recruitment onto target promoters of an HDAC complex is not a general property of transcriptional repressors containing a conserved BTB/POZ domain. ..
  49. Yu D, Rao S, Tsai L, Lee S, He Y, Sutcliffe E, et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity. 2009;31:457-68 pubmed publisher
    ..Thus, Bcl-6 positively directs Tfh cell differentiation, through combined repression of miRNAs and transcription factors...
  50. Barros P, Jordan P, Matos P. Rac1 signaling modulates BCL-6-mediated repression of gene transcription. Mol Cell Biol. 2009;29:4156-66 pubmed publisher
    ..Together, these data provide substantial evidence that Rac1 signaling inhibits the transcriptional repressor BCL-6 in colorectal cells and reveal a novel pathway that links Rac1 signaling to the regulation of gene transcription. ..
  51. Cerchietti L, Lopes E, Yang S, Hatzi K, Bunting K, Tsikitas L, et al. A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas. Nat Med. 2009;15:1369-76 pubmed publisher
    ..PU-H71 also induced cell death in primary human DLBCL specimens. ..
  52. Pasqualucci L, Dominguez Sola D, Chiarenza A, Fabbri G, Grunn A, Trifonov V, et al. Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature. 2011;471:189-95 pubmed publisher
    ..We demonstrate specific defects in acetylation-mediated inactivation of the BCL6 oncoprotein and activation of the p53 tumour suppressor...
  53. Huynh K, Fischle W, Verdin E, Bardwell V. BCoR, a novel corepressor involved in BCL-6 repression. Genes Dev. 2000;14:1810-23 pubmed
    ..Additionally, interactions between the BCL-6 POZ domain and SMRT, N-CoR, and BCoR are mutually exclusive. The specificity of the BCL-6/BCoR interaction suggests that BCoR may have a role in BCL-6-associated lymphomas. ..
  54. Bos R, van Diest P, van der Groep P, Greijer A, Hermsen M, Heijnen I, et al. Protein expression of B-cell lymphoma gene 6 (BCL-6) in invasive breast cancer is associated with cyclin D1 and hypoxia-inducible factor-1alpha (HIF-1alpha). Oncogene. 2003;22:8948-51 pubmed
    ..The cases with amplification in BCL-6 showed an increased (25%) incidence of BCL-6 protein overexpression. Thus, this study is the first to show that BCL-6 oncogene activation plays a role in cancers other than lymphomas. ..
  55. Phan R, Saito M, Kitagawa Y, Means A, Dalla Favera R. Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells. Nat Immunol. 2007;8:1132-9 pubmed
    ..Because Bcl-6 is required for the maintenance of germinal centers, our findings suggest that the extent of genotoxic stress controls the fate of germinal center B cells by means of Bcl-6. ..
  56. David G, Alland L, Hong S, Wong C, DePinho R, Dejean A. Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. Oncogene. 1998;16:2549-56 pubmed
    ..a krüppel-like zinc finger protein with a POZ domain shared with a subset of regulatory proteins including the BCL6 leukemogenic protein. PLZF, like BCL6, strongly represses transcription initiated from different promoters...
  57. Kanazawa N, Moriyama M, Onizuka T, Sugawara K, Mori S. Expression of bcl-6 protein in normal skin and epidermal neoplasms. Pathol Int. 1997;47:600-7 pubmed
    ..These results suggest that the expression of bcl-6 protein may be associated with morphological differentiation in normal and neoplastic epidermal cells. ..
  58. Parekh S, Polo J, Shaknovich R, Juszczynski P, Lev P, Ranuncolo S, et al. BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms. Blood. 2007;110:2067-74 pubmed
    The BCL6 transcriptional repressor is the most commonly involved oncogene in diffuse large B-cell lymphomas (DLBCLs)...