Gene Symbol: BCL2A1
Description: BCL2 related protein A1
Alias: ACC-1, ACC-2, ACC1, ACC2, BCL2L5, BFL1, GRS, HBPA1, bcl-2-related protein A1, bcl-2-like protein 5, bcl2-L-5, hematopoietic BCL2-related protein A1, hemopoietic-specific early response protein, protein BFL-1
Species: human
Products:     BCL2A1

Top Publications

  1. Herold M, Zeitz J, Pelzer C, Kraus C, Peters A, Wohlleben G, et al. The stability and anti-apoptotic function of A1 are controlled by its C terminus. J Biol Chem. 2006;281:13663-71 pubmed
    ..In conclusion, our data demonstrate that the C terminus serves a dual function by controlling the stability of A1 and by amplifying the capacity of the protein to protect cells against apoptosis. ..
  2. Kenny J, Knobloch T, Augustus M, Carter K, Rosen C, Lang J. GRS, a novel member of the Bcl-2 gene family, is highly expressed in multiple cancer cell lines and in normal leukocytes. Oncogene. 1997;14:997-1001 pubmed
    ..1994). The FGF-4 gene was truncated by DNA rearrangement with a novel gene named GRS. In this manuscript we describe isolation of GRS cDNA and show by sequence comparison that GRS is a novel member of ..
  3. Zong W, Edelstein L, Chen C, Bash J, Gelinas C. The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis. Genes Dev. 1999;13:382-7 pubmed
    ..The activation of Bfl-1 may be the means by which NF-kappaB functions in oncogenesis and promotes cell resistance to anti-cancer therapy. ..
  4. Morales A, Olsson A, Celsing F, Osterborg A, Jondal M, Osorio L. High expression of bfl-1 contributes to the apoptosis resistant phenotype in B-cell chronic lymphocytic leukemia. Int J Cancer. 2005;113:730-7 pubmed
    ..05). We conclude that bfl-1 may be an important regulator of B-CLL apoptosis, which could contribute to disease progression and resistance to chemotherapy, and as such represent a future potential therapeutic target. ..
  5. Yang W, Ko J, Park S, Choi H, Kim Y, Kim C. C-terminal region of Bfl-1 induces cell death that accompanies caspase activation when fused with GFP. J Cell Biochem. 2005;94:1234-47 pubmed
    ..However, the over-expression of anti-apoptotic molecules, such as Bcl-x(L) and CrmA, did not block GFP-BC-induced cell death. In summary, GFP-BC induces cell death with caspase activation through mitochondria dependent process. ..
  6. Ko J, Choi K, Pan Z, Lin P, Weisleder N, Kim C, et al. The tail-anchoring domain of Bfl1 and HCCS1 targets mitochondrial membrane permeability to induce apoptosis. J Cell Sci. 2007;120:2912-23 pubmed
    Many Bcl2 family proteins target intracellular membranes by their C-terminal tail-anchor domain. Bfl1 is a bi-functional Bcl2 family protein with both anti- and pro-apoptotic activities and contains an amphipathic tail-anchoring peptide (..
  7. Simmons M, Fan G, Zong W, Degenhardt K, White E, Gelinas C. Bfl-1/A1 functions, similar to Mcl-1, as a selective tBid and Bak antagonist. Oncogene. 2008;27:1421-8 pubmed
    ..Thus, part of the protective function of NF-kappaB is to induce Mcl-1-like activity by upregulating Bfl-1. ..
  8. Karsan A, Yee E, Harlan J. Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1. J Biol Chem. 1996;271:27201-4 pubmed
    ..Ceramide-activated endothelial death is also inhibited by A1, suggesting that TNF may initiate divergent survival and death pathways via separate lipid second messengers. ..
  9. Carrio R, Lopez Hoyos M, Jimeno J, Benedict M, Merino R, Benito A, et al. A1 demonstrates restricted tissue distribution during embryonic development and functions to protect against cell death. Am J Pathol. 1996;149:2133-42 pubmed
    ..Furthermore, its distribution in multiple tissues of the embryo suggests that A1 plays a role in the regulation of physiological cell death during embryonic development. ..

More Information

Publications114 found, 100 shown here

  1. Zhang H, Cowan Jacob S, Simonen M, Greenhalf W, Heim J, Meyhack B. Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells. J Biol Chem. 2000;275:11092-9 pubmed
    ..e. a hydrophobic pocket for the binding of proapoptotic proteins, rather than extended sequence homologies. ..
  2. D Souza B, Edelstein L, Pegman P, Smith S, Loughran S, Clarke A, et al. Nuclear factor kappa B-dependent activation of the antiapoptotic bfl-1 gene by the Epstein-Barr virus latent membrane protein 1 and activated CD40 receptor. J Virol. 2004;78:1800-16 pubmed
    ..These findings highlight the role of LMP1 as a mediator of EBV-host cell interactions and may indicate an important route by which it exerts its cellular growth transforming properties. ..
  3. Certo M, Del Gaizo Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong S, et al. Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell. 2006;9:351-65 pubmed
    ..Our data allow us to distinguish a cellular state we call "primed for death," which can be determined by BH3 profiling and which correlates with dependence on antiapoptotic family members for survival. ..
  4. Herman M, Nyman T, Welin M, Lehtiö L, Flodin S, Trésaugues L, et al. Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim. FEBS Lett. 2008;582:3590-4 pubmed publisher
  5. Brien G, Debaud A, Robert X, Oliver L, Trescol Biemont M, Cauquil N, et al. C-terminal residues regulate localization and function of the antiapoptotic protein Bfl-1. J Biol Chem. 2009;284:30257-63 pubmed publisher
    ..Our data clearly indicate that this property of helix alpha9 is required for the anchorage of Bfl-1 to the mitochondria but also regulates the antiapoptotic function Bfl-1. ..
  6. Lin E, Orlofsky A, Berger M, Prystowsky M. Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2. J Immunol. 1993;151:1979-88 pubmed
    ..These data demonstrate that A1 is a novel early-response gene whose expression is associated with a variety of stimuli and occurs in several hemopoietic cell types. ..
  7. Wang C, Guttridge D, Mayo M, Baldwin A. NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol Cell Biol. 1999;19:5923-9 pubmed
    ..Our findings demonstrate that A1 is an important antiapoptotic gene controlled by NF-kappaB and establish that the prosurvival function of NF-kappaB can be manifested at multiple levels. ..
  8. Edelstein L, Lagos L, Simmons M, Tirumalai H, Gelinas C. NF-kappa B-dependent assembly of an enhanceosome-like complex on the promoter region of apoptosis inhibitor Bfl-1/A1. Mol Cell Biol. 2003;23:2749-61 pubmed
    ..To our knowledge, this is the first demonstration of enhanceosome-mediated regulation of a cell death inhibitor. ..
  9. Choi S, Park I, Yun J, Sung Y, Hong S, Shin H. A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow. Oncogene. 1995;11:1693-8 pubmed
    ..It is conceivable that Bfl-1 is involved in the promotion of the cell survival in the stomach cancer development or progression. ..
  10. Karsan A, Yee E, Kaushansky K, Harlan J. Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells. Blood. 1996;87:3089-96 pubmed
    ..Additionally, vascular smooth muscle cells and various nonhematopoietic tissues express human Al, indicating that human Al is a widely expressed Bcl-2 homologue. ..
  11. Duriez P, Wong F, Dorovini Zis K, Shahidi R, Karsan A. A1 functions at the mitochondria to delay endothelial apoptosis in response to tumor necrosis factor. J Biol Chem. 2000;275:18099-107 pubmed
    ..However, a mitochondria-independent caspase pathway eventually results in endothelial death despite mitochondrial protection by A1. ..
  12. Werner A, de Vries E, Tait S, Bontjer I, Borst J. Bcl-2 family member Bfl-1/A1 sequesters truncated bid to inhibit is collaboration with pro-apoptotic Bak or Bax. J Biol Chem. 2002;277:22781-8 pubmed
    ..Lack of demonstrable interaction between Bfl-1 and Bak or Bax in the mitochondrial membrane suggests that Bfl-1 generally prevents the formation of a pro-apoptotic complex by sequestering BH3 domain-only proteins. ..
  13. Chen L, Willis S, Wei A, Smith B, Fletcher J, Hinds M, et al. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell. 2005;17:393-403 pubmed
    ..The results suggest that apoptosis relies on selective interactions between particular subsets of these proteins and that it should be feasible to discover BH3-mimetic drugs that inactivate specific prosurvival targets. ..
  14. Mazzio E, Soliman K. Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A. Cancer Genomics Proteomics. 2018;15:349-364 pubmed publisher
    ..polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3), carbonic anhydrase 14 (CAXIV), BCL2-related protein A1 (BCL2A1), protein kinase C delta (PRKCD), transient receptor potential cation channel subfamily M member 1 (TRPM1), ..
  15. Hwang K, Hwang Y, Kim G, Choe J. Extracts from Aralia elata (Miq) Seem alleviate hepatosteatosis via improving hepatic insulin sensitivity. BMC Complement Altern Med. 2015;15:347 pubmed publisher
    ..Additionally, AE extract decreased PI3K and Akt activity. Our results suggest that treatment with AE extract ameliorated NAFLD by inhibiting insulin resistance through activation of the Akt/GLUT4 pathway. ..
  16. Kim J, Kang E, Park M, Kim J, Kim S, Jeung E, et al. The adverse effect of 4-tert-octylphenol on fat metabolism in pregnant rats via regulation of lipogenic proteins. Environ Toxicol Pharmacol. 2015;40:284-91 pubmed publisher
    ..The altered fat metabolism by OP may affect the nutrition balance during pregnancy and can cause metabolism-related diseases. ..
  17. Molepo M, Ayeleso A, Nyakudya T, Erlwanger K, Mukwevho E. A Study on Neonatal Intake of Oleanolic Acid and Metformin in Rats (Rattus norvegicus) with Metabolic Dysfunction: Implications on Lipid Metabolism and Glucose Transport. Molecules. 2018;23: pubmed publisher
    ..The present study shows that neonatal oral administration of oleanolic acid and metformin potentially protects against the development of fructose-induced metabolic dysfunction in the rats in both short and long time periods. ..
  18. Sevilla L, Perez P. Roles of the Glucocorticoid and Mineralocorticoid Receptors in Skin Pathophysiology. Int J Mol Sci. 2018;19: pubmed publisher
    ..However, a major mechanism for specific activation of GRs and/or MRs is at the pre-receptor level by modulating the local availability of active GCs...
  19. Pisu M, Garau A, Boero G, Biggio F, Pibiri V, Dore R, et al. Sex differences in the outcome of juvenile social isolation on HPA axis function in rats. Neuroscience. 2016;320:172-82 pubmed publisher
    ..impairs feedback inhibition in both sexes in which an increase in the abundance of glucocorticoid receptors (GRs) in the hippocampus was found...
  20. Meng X, Li S, Qin C, Zhu Z, Hu W, Yang L, et al. Intestinal microbiota and lipid metabolism responses in the common carp (Cyprinus carpio L.) following copper exposure. Ecotoxicol Environ Saf. 2018;160:257-264 pubmed publisher
  21. Gou S, Huang H, Chen X, Liu J, He M, Ma Y, et al. Lipid-lowering, hepatoprotective, and atheroprotective effects of the mixture Hong-Qu and gypenosides in hyperlipidemia with NAFLD rats. J Chin Med Assoc. 2016;79:111-21 pubmed publisher
  22. Yamamoto Y, Kida H, Kagawa Y, Yasumoto Y, Miyazaki H, Islam A, et al. FABP3 in the Anterior Cingulate Cortex Modulates the Methylation Status of the Glutamic Acid Decarboxylase67 Promoter Region. J Neurosci. 2018;38:10411-10423 pubmed publisher
    ..These suggest that FABP3 regulates GABA synthesis through transcriptional regulation of Gad67 in the ACC. ..
  23. Bhise K, Bhagwat P, Dandge P. Synergistic effect of Chryseobacterium gleum sp. SUK with ACC deaminase activity in alleviation of salt stress and plant growth promotion in Triticum aestivum L. 3 Biotech. 2017;7:105 pubmed publisher
    ..Therefore, application of novel bioformulation could increase the yield of crops by ameliorating growth of plants and alleviating the salinity stress. ..
  24. Chrousos G, Kino T. Glucocorticoid signaling in the cell. Expanding clinical implications to complex human behavioral and somatic disorders. Ann N Y Acad Sci. 2009;1179:153-66 pubmed publisher
    ..The GRs consist of multifunctional domain proteins operating as ligand-dependent transcription factors that interact with ..
  25. Shang T, Liu L, Zhou J, Zhang M, Hu Q, Fang M, et al. Protective effects of various ratios of DHA/EPA supplementation on high-fat diet-induced liver damage in mice. Lipids Health Dis. 2017;16:65 pubmed publisher
  26. Liu Z, Liu W, Huang Y, Guo J, Zhao R, Yang X. Lipopolysaccharide significantly influences the hepatic triglyceride metabolism in growing pigs. Lipids Health Dis. 2015;14:64 pubmed publisher
    ..LPS infection has a profound impact on hepatic TG metabolism. This impact is mainly demonstrated by the significantly deceased de novo lipogenesis, and GR may involve in its regulation. ..
  27. Cheuquemán C, Loren P, Arias M, Risopatrón J, Felmer R, Álvarez J, et al. Effects of short-term exposure of mature oocytes to sodium nitroprusside on in vitro embryo production and gene expression in bovine. Theriogenology. 2015;84:1431-7 pubmed publisher
    ..iNOS, eNOS, and nNOS), stress tolerance (HSP70 and HSP90), oxidative stress (HIF1A and PRDX5), and apoptosis (BCL2A1)...
  28. Cheng T, Dimitrov S, Pruitt C, Hong S. Glucocorticoid mediated regulation of inflammation in human monocytes is associated with depressive mood and obesity. Psychoneuroendocrinology. 2016;66:195-204 pubmed publisher
    ..Glucocorticoid (GC) resistance and desensitization of peripheral GC receptors (GRs) are often the case in HPA dysregulation seen in depression, and GC plays a critical role in regulation of ..
  29. Thangaraju M, Sharan S, Sterneck E. Comparison of mammary gland involution between 129S1 and C57BL/6 inbred mouse strains: differential regulation of Bcl2a1, Trp53, Cebpb, and Cebpd expression. Oncogene. 2004;23:2548-53 pubmed
    ..C57BL/6 inbred strains and report significant differences at the molecular level with differential expression of Bcl2a1 (Bfl1), Trp53 (p53), Cebpb (C/EBP beta), and Cebpd (C/EBP delta)...
  30. Christiansen J, Backeljauw P, Bidlingmaier M, Biller B, Boguszewski M, Casanueva F, et al. Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations. Eur J Endocrinol. 2016;174:C1-8 pubmed publisher
    The Growth Hormone (GH) Research Society (GRS) convened a workshop to address important issues regarding trial design, efficacy, and safety of long-acting growth hormone preparations (LAGH)...
  31. Garg P, Kidambi A, Swoboda P, Foley J, Musa T, Ripley D, et al. The role of left ventricular deformation in the assessment of microvascular obstruction and intramyocardial haemorrhage. Int J Cardiovasc Imaging. 2017;33:361-370 pubmed publisher
    ..Infarct size, MVO and IMH were quantified. Peak global longitudinal strain (GLS), global radial strain (GRS), global circumferential strain (GCS) and their strain rates were derived by feature tracking analysis of LV short-..
  32. Vera B, Dashti H, Gómez Abellán P, Hernández Martínez A, Esteban A, Scheer F, et al. Modifiable lifestyle behaviors, but not a genetic risk score, associate with metabolic syndrome in evening chronotypes. Sci Rep. 2018;8:945 pubmed publisher
    ..In order to capture a biological contribution to chronotype, a genetic-risk-score (GRS), comprised of 15 chronotype-related variants, was tested...
  33. Hsu S, Lin P, Hsueh A. BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Mol Endocrinol. 1998;12:1432-40 pubmed
    ..Identification of BOD expands the group of proapoptotic Bcl-2 proteins that only contains the BH3 domain and allows future elucidation of the intracellular mechanism for apoptosis regulation in ovary and other tissues. ..
  34. Marié P, Labas V, Brionne A, Harichaux G, Hennequet Antier C, Rodriguez Navarro A, et al. Quantitative proteomics provides new insights into chicken eggshell matrix protein functions during the primary events of mineralisation and the active calcification phase. J Proteomics. 2015;126:140-54 pubmed publisher
    ..They correspond to numerous molecular chaperones including CLU, PPIB and OCX21, protease and protease inhibitors including OVM and CST3, and regulators of phosphorylation. ..
  35. Robertson H. The Insect Chemoreceptor Superfamily Is Ancient in Animals. Chem Senses. 2015;40:609-14 pubmed publisher
    The insect chemoreceptor superfamily consists of 2 gene families, the highly diverse gustatory receptors (GRs) found in all arthropods with sequenced genomes and the odorant receptors that evolved from a GR lineage and have been found ..
  36. Antony B, Soffan A, Jakše J, Abdelazim M, Aldosari S, Aldawood A, et al. Identification of the genes involved in odorant reception and detection in the palm weevil Rhynchophorus ferrugineus, an important quarantine pest, by antennal transcriptome analysis. BMC Genomics. 2016;17:69 pubmed publisher
    ..CSPs), odorant receptors/co-receptors (ORs/Orcos), sensory neuron membrane proteins (SNMPs), gustatory receptors (GRs) and ionotropic receptors (IRs)...
  37. Lehner M, Wisłowska Stanek A, Gryz M, Sobolewska A, Turzyńska D, Chmielewska N, et al. The co-expression of GluN2B subunits of the NMDA receptors and glucocorticoid receptors after chronic restraint stress in low and high anxiety rats. Behav Brain Res. 2017;319:124-134 pubmed publisher
    ..We analysed the expression of the GluN2B subunits of the NMDA and glucocorticoid receptors (GRs) in selected brain structures (immunofluorescence)...
  38. Chung C, Lee C, Chen M, Lee K, Lan C, Kwan A, et al. Combined Genetic Biomarkers and Betel Quid Chewing for Identifying High-Risk Group for Oral Cancer Occurrence. Cancer Prev Res (Phila). 2017;10:355-362 pubmed publisher
    We integrated genetic risk scores (GRS) and environmental factors for identifying high-risk subjects for oral squamous cell carcinoma (OSCC) occurrence by using case-control study...
  39. Machiela M, Hofmann J, Carreras Torres R, Brown K, Johansson M, Wang Z, et al. Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma. Eur Urol. 2017;72:747-754 pubmed publisher
    ..controls from six genome-wide association studies (GWAS) of RCC were aggregated into a weighted genetic risk score (GRS) predictive of leukocyte telomere length...
  40. Rios Garcia M, Steinbauer B, Srivastava K, Singhal M, Mattijssen F, Maida A, et al. Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence. Cell Metab. 2017;26:842-855.e5 pubmed publisher
    ..Here, we define the lipogenic enzyme acetyl-CoA carboxylase (ACC) 1 as a key player in breast cancer metastasis. ACC1 phosphorylation was increased in invading cells both in murine and human breast cancer, serving as a point of ..
  41. Cousminer D, Mitchell J, Chesi A, Roy S, Kalkwarf H, Lappe J, et al. Genetically Determined Later Puberty Impacts Lowered Bone Mineral Density in Childhood and Adulthood. J Bone Miner Res. 2017;: pubmed publisher
    ..We constructed sex-specific polygenic risk scores (GRS) consisting of 333 genetic variants associated with later puberty in European-descent children in the Bone Mineral ..
  42. Shih Y, Yu H, Chen W, Liao K, Lin H, Yang Y. The effect of additional joint mobilization on neuromuscular performance in individuals with functional ankle instability. Phys Ther Sport. 2018;30:22-28 pubmed publisher
    ..YBT), dorsiflexion range of motion (DFROM), Cumberland ankle instability tool (CAIT), and global rating scale (GRS). Two-way repeated measures MANOVA were used with the significance level p?<?.05...
  43. Fukuhara S, Chang I, Mitsui Y, Chiyomaru T, Yamamura S, Majid S, et al. Functional role of DNA mismatch repair gene PMS2 in prostate cancer cells. Oncotarget. 2015;6:16341-51 pubmed
    ..PMS2 expression and observe the apoptosis-related TMS1 gene to be significantly upregulated whereas anti-apoptotic BCL2A1 was downregulated...
  44. Sleegers K, Bettens K, De Roeck A, Van Cauwenberghe C, Cuyvers E, Verheijen J, et al. A 22-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid Aβ42. Alzheimers Dement. 2015;11:1452-1460 pubmed publisher
    ..We evaluated the discriminative ability of a genetic risk score (GRS) covering 22 published genetic risk loci for AD in 1162 Flanders-Belgian AD patients and 1019 controls and assessed ..
  45. Hindieh W, Pilote L, Cheema A, Al Lawati H, Labos C, Dufresne L, et al. Association Between Family History, a Genetic Risk Score, and Severity of Coronary Artery Disease in Patients With Premature Acute Coronary Syndromes. Arterioscler Thromb Vasc Biol. 2016;36:1286-92 pubmed publisher
    A genetic risk score (GRS) for coronary artery disease has recently been shown to be independent of family history (FHx) in predicting future cardiovascular events...
  46. Boza C, León F, Buckel E, Riquelme A, Crovari F, Martinez J, et al. Simulation-trained junior residents perform better than general surgeons on advanced laparoscopic cases. Surg Endosc. 2017;31:135-141 pubmed publisher
    ..Global rating scale (GRS) and specific rating scale scores, operative time and the distance traveled by both hands measured with a tracking ..
  47. Agnihotri A, Roy A, Joshi R. Gustatory receptors in Lepidoptera: chemosensation and beyond. Insect Mol Biol. 2016;25:519-29 pubmed publisher
    ..Members of the G-protein coupled receptor family, gustatory receptors (GRs), are an integral part of the Lepidoptera chemosensory machinery...
  48. Yoon Y, Kang S, Choi H, Jeong S, Sung J, Lee S, et al. Prediction of infarct size and adverse cardiac outcomes by tissue tracking-cardiac magnetic resonance imaging in ST-segment elevation myocardial infarction. Eur Radiol. 2018;28:3454-3463 pubmed publisher
    ..analysis was applied to cine-images to measure global LV radial, circumferential and longitudinal peak strains (GRS, GCS and GLS, respectively)...
  49. Su A, Milbrandt T, Larson A. Magnetic Expansion Control System Achieves Cost Savings Compared to Traditional Growth Rods: An Economic Analysis Model. Spine (Phila Pa 1976). 2015;40:1851-6 pubmed publisher
    ..We hypothesized that over time the MG will become more cost-effective. Traditional GRs provide effective treatment, but require periodic lengthening surgery...
  50. Dixon S, Nagle C, Thrift A, Pharoah P, Pearce C, Zheng W, et al. Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study. Int J Epidemiol. 2016;45:884-95 pubmed publisher
    ..We constructed a weighted genetic risk score (GRS, partial F-statistic = 172), summing alleles at 87 single nucleotide polymorphisms previously associated with BMI, ..
  51. Kim Y, Kim M, Kang J, Kim H, Park J, Lee J, et al. Transcriptome sequencing of gingival biopsies from chronic periodontitis patients reveals novel gene expression and splicing patterns. Hum Genomics. 2016;10:28 pubmed publisher
    ..The EDB exon was predominantly included in FN1, while exon 2 was mostly skipped in BCL2A1. These findings using RNA sequencing provide novel insights into the pathogenesis mechanism of periodontitis in ..
  52. Latsuzbaia A, Jaddoe V, Hofman A, Franco O, Felix J. Associations of genetic variants for adult lipid levels with lipid levels in children. The Generation R Study. J Lipid Res. 2016;57:2185-2192 pubmed
    ..in mean absolute lipid and lipoprotein values between the 10% of children with the highest lipid or lipoprotein GRS versus the 10% with the lowest score were 0.28, 0.25, 0.32, and 0...
  53. Yoo J, McCoy K, Carty S, Stang M, Armstrong M, Howell G, et al. Adrenal Imaging Features Predict Malignancy Better than Tumor Size. Ann Surg Oncol. 2015;22 Suppl 3:S721-7 pubmed publisher
    ..55 %) with equivalent specificity. Regardless of mass size, adrenalectomy should be strongly considered when non-benign ImF are present. ..
  54. Larifla L, Beaney K, Foucan L, Bangou J, Michel C, Martino J, et al. Influence of Genetic Risk Factors on Coronary Heart Disease Occurrence in Afro-Caribbeans. Can J Cardiol. 2016;32:978-85 pubmed publisher
    ..A genetic risk score (GRS) incorporating the 19 SNPs was calculated...
  55. Perry D, Wasserfall C, Oram R, Williams M, Posgai A, Muir A, et al. Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling. Sci Rep. 2018;8:4529 pubmed publisher
    ..We determined the capacity for a combined genetic risk score (GRS) to discriminate disease-risk subgroups in a racially and ethnically diverse cohort from the southeastern U.S...
  56. Kullo I, Jouni H, Olson J, Montori V, Bailey K. Design of a randomized controlled trial of disclosing genomic risk of coronary heart disease: the Myocardial Infarction Genes (MI-GENES) study. BMC Med Genomics. 2015;8:51 pubmed publisher
    Whether disclosure of a genetic risk score (GRS) for a common disease influences relevant clinical outcomes is unknown...
  57. Maruno M, Kiyosue H, Tanoue S, Hongo N, Mori H. Balloon-Occluded Retrograde Transvenous Obliteration for Isolated Gastric Varices Draining through Pericardiophrenic Vein without Gastrorenal or Gastrocaval Shunts. J Vasc Interv Radiol. 2016;27:203-7 pubmed publisher
    ..invasive treatment for isolated gastric varices (GVs) that is usually performed through a gastrorenal shunt (GRS) or gastrocaval shunt (GCS)...
  58. Wang C, Dai J, Sun Y, Xie L, Pan L, Hu Z, et al. [Genetic risk score: principle, methods and application]. Zhonghua Liu Xing Bing Xue Za Zhi. 2015;36:1062-4 pubmed
    Genetic risk score (GRS) is used for evaluating the effects of genetic susceptible factors in risk prediction models. Five methods are commonly used for GRS: i.e...
  59. Huang Y, Xu M, Xie L, Wang T, Huang X, Lv X, et al. Obesity and peripheral arterial disease: A Mendelian Randomization analysis. Atherosclerosis. 2016;247:218-24 pubmed publisher
    ..PAD was defined as ankle-to-brachial index (ABI) <0.90 or >1.40. Weighted BMI genetic risk score (GRS) was used as the Instrumental Variable (IV)...
  60. Tosto G, Bird T, Tsuang D, Bennett D, Boeve B, Cruchaga C, et al. Polygenic risk scores in familial Alzheimer disease. Neurology. 2017;88:1180-1186 pubmed publisher
    To investigate the association between a genetic risk score (GRS) and familial late-onset Alzheimer disease (LOAD) and its predictive value in families multiply affected by the disease...
  61. Vojinovic J, Tincani A, Sulli A, Soldano S, Andreoli L, Dall Ara F, et al. European multicentre pilot survey to assess vitamin D status in rheumatoid arthritis patients and early development of a new Patient Reported Outcome questionnaire (D-PRO). Autoimmun Rev. 2017;16:548-554 pubmed publisher
    ..consisted of three domains, Symptom Risk Score (SRS), Habitus Risk Score (HRS) and Global Risk Score (SRS+HRS=GRS), constructed with items possibly related to vitamin D deficiency...
  62. Davidson L, Utarnachitt R, Mason A, Sawyer T. Development and Testing of a Neonatal Intubation Checklist for an Air Medical Transport Team. Air Med J. 2018;37:41-45 pubmed publisher
    ..was evaluated using a validated assessment tool that included a proficiency score, a global rating scale (GRS) score, and time to perform the procedure...
  63. Shimohigashi Y, Araki F, Maruyama M, Yonemura K, Nakaguchi Y, Kai Y, et al. Image quality of four-dimensional cone-beam computed tomography obtained at various gantry rotation speeds for liver stereotactic body radiation therapy with fiducial markers. Phys Med. 2018;45:19-24 pubmed publisher
    ..6 to 10.1, from 39.8 to 10.1, and from 0.9 to 0.7, respectively, as the GRS increased from 50 to 200°?min-1. The fiducial marker positions were within 2.0?mm at all GRSs...
  64. Kurek A, Głombik K, Detka J, Basta Kaim A, Kubera M, Lasoń W, et al. Regulators of glucocorticoid receptor function in an animal model of depression and obesity. J Neuroendocrinol. 2018;: pubmed publisher
    ..The aim of the present study was to determine the expression of glucocorticoid receptors (GRs) and mineralocorticoid receptors (MRs) and the factors that affect GR function (FKBP51, Bag-1 and HSP70) in a ..
  65. Diószegi J, Fiatal S, Toth R, Moravcsik Kornyicki Á, Kósa Z, Sandor J, et al. Distribution Characteristics and Combined Effect of Polymorphisms Affecting Alcohol Consumption Behaviour in the Hungarian General and Roma Populations. Alcohol Alcohol. 2017;52:104-111 pubmed publisher
    ..Differences in genotype and allele distributions were investigated. Genetic risk scores (GRS) were generated to estimate the joint effect of individual single-nucleotide polymorphisms (SNPs)...
  66. Pegman P, Smith S, D Souza B, Loughran S, Maier S, Kempkes B, et al. Epstein-Barr virus nuclear antigen 2 trans-activates the cellular antiapoptotic bfl-1 gene by a CBF1/RBPJ kappa-dependent pathway. J Virol. 2006;80:8133-44 pubmed publisher
    ..These findings are relevant to our understanding of EBV persistence, its role in malignant disease, and the B-cell developmental process...
  67. Kinoshita M, Numata S, Tajima A, Nishi A, Muraki S, Tsuchiya A, et al. Cumulative effect of the plasma total homocysteine-related genetic variants on schizophrenia risk. Psychiatry Res. 2016;246:833-837 pubmed publisher
    ..Then, we evaluated the cumulative effects of three SNPs on SCZ risk by calculating the Genotype Risk Score (GRS) (1120 cases, 2643 controls)...
  68. Huang C, De Ravin S, Paul A, Heller T, Ho N, Wu Datta L, et al. Genetic Risk for Inflammatory Bowel Disease Is a Determinant of Crohn's Disease Development in Chronic Granulomatous Disease. Inflamm Bowel Dis. 2016;22:2794-2801 pubmed
    ..We hypothesized that the overall IBD genetic risk, determined by IBD genetic risk score (GRS), might in part determine IBD development in CGD...
  69. Wang T, Shi C, Li X, Zhang P, Liu B, Wang H, et al. Injection of oxytocin into paraventricular nucleus reverses depressive-like behaviors in the postpartum depression rat model. Behav Brain Res. 2018;336:236-243 pubmed publisher
    ..nucleus (PVN) and possible signaling pathway involved in a PPD rat model induced by gestation restraint stress (GRS)...
  70. Macaire H, Riquet A, Moncollin V, Biémont Trescol M, Duc Dodon M, Hermine O, et al. Tax protein-induced expression of antiapoptotic Bfl-1 protein contributes to survival of human T-cell leukemia virus type 1 (HTLV-1)-infected T-cells. J Biol Chem. 2012;287:21357-70 pubmed publisher
    ..Our results directly implicate Bfl-1 and Bcl-x(L) in HTLV-1-infected T-cell survival and suggest that both Bfl-1 and Bcl-x(L) represent potential therapeutic targets for ATLL treatment. ..
  71. Franc J, Verde M, Gallardo A, Carenzo L, Ingrassia P. An Italian version of the Ottawa Crisis Resource Management Global Rating Scale: a reliable and valid tool for assessment of simulation performance. Intern Emerg Med. 2017;12:651-656 pubmed publisher
    ..Translation of a published English language tool, the Ottawa Crisis Resource Management Global Rating Scale (GRS), may lead to a validated and reliable tool...
  72. García Pérez D, Ferenczi S, Kovacs K, Laorden M, Milanes M, Nunez C. Different contribution of glucocorticoids in the basolateral amygdala to the formation and expression of opiate withdrawal-associated memories. Psychoneuroendocrinology. 2016;74:350-362 pubmed publisher
    ..that GCs levels remained at basal levels in all experimental groups following memory retrieval, and consequently GRs no longer acted as transcriptional regulators...
  73. Warda A, Xiao Y, Boekhorst J, Wells Bennik M, Nierop Groot M, Abee T. Analysis of Germination Capacity and Germinant Receptor (Sub)clusters of Genome-Sequenced Bacillus cereus Environmental Isolates and Model Strains. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..Whole-genome sequence comparison revealed a total of 11 clusters of operons encoding germinant receptors (GRs): GerK, GerI, and GerL were present in all strains, whereas GerR, GerS, GerG, GerQ, GerX, GerF, GerW, and GerZ (sub)..
  74. Borch Pedersen K, Mellegård H, Reineke K, Boysen P, Sevenich R, Lindbäck T, et al. Effects of High Pressure on Bacillus licheniformis Spore Germination and Inactivation. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..Pressurization at <300 MPa triggers spore germination by activating germination receptors (GRs), while pressurization at >300 MPa likely triggers germination by opening dipicolinic acid (DPA) channels ..
  75. Woolston A, Hsiao P, Kuo P, Wang S, Lien Y, Liu C, et al. Genetic loci associated with an earlier age at onset in multiplex schizophrenia. Sci Rep. 2017;7:6486 pubmed publisher
    ..Multi-SNP genetic risk scores (GRS) composed of the candidate loci were used to distinguish patients with an early or late AAO...
  76. Li X, Ma J, Xu J, Zhu D, Li A, Che Y, et al. Puerarin and Amlodipine Improvement of D-Galactose-Induced Impairments of Behaviour and Neurogenesis in Mouse Dentate Gyrus: Correlation with Glucocorticoid Receptor Expression. Neurochem Res. 2017;42:3268-3278 pubmed publisher
    Glucocorticoid receptors (GRs) exert actions on the hippocampus that are important for memory formation. There are correlations between vascular dysfunctions and GR-related gene expression...
  77. Zanon Moreno V, Ortega Azorín C, Asensio Marquez E, Garcia Medina J, Pinazo Duran M, Coltell O, et al. A Multi-Locus Genetic Risk Score for Primary Open-Angle Glaucoma (POAG) Variants Is Associated with POAG Risk in a Mediterranean Population: Inverse Correlations with Plasma Vitamin C and E Concentrations. Int J Mol Sci. 2017;18: pubmed publisher
    ..association studies (GWASs) and POAG risk, both separately and as an aggregated multi-locus genetic risk score (GRS)...
  78. Swingler S, Mann A, Zhou J, Swingler C, Stevenson M. Apoptotic killing of HIV-1-infected macrophages is subverted by the viral envelope glycoprotein. PLoS Pathog. 2007;3:1281-90 pubmed
    ..The anti-cancer agent Imatinib inhibited M-CSF receptor activation and restored the apoptotic sensitivity of HIV-1-infected macrophages, suggesting a novel strategy to curtail viral persistence in the macrophage reservoir. ..
  79. Singh R, Kunkalla K, Qu C, Schlette E, Neelapu S, Samaniego F, et al. ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma. Oncogene. 2011;30:4874-86 pubmed publisher
    ..of DLBCL cells with HS-5 cells also resulted in increase expression of the antiapoptotic proteins BCL2, BCL-xL and BCL2A1 and in induced chemotolerance to doxorubicin and methotrexate, drugs routinely used for the treatment of DLBCL...
  80. de Lauzon Guillain B, Clifton E, Day F, Clement K, Brage S, Forouhi N, et al. Mediation and modification of genetic susceptibility to obesity by eating behaviors. Am J Clin Nutr. 2017;106:996-1004 pubmed publisher
    ..The mediating effect of each eating behavior on the association between the BMI-GRS and measured BMI was assessed by using the Sobel test...
  81. Hosseini Esfahani F, Koochakpoor G, Daneshpour M, Sedaghati Khayat B, Mirmiran P, Azizi F. Mediterranean Dietary Pattern Adherence Modify the Association between FTO Genetic Variations and Obesity Phenotypes. Nutrients. 2017;9: pubmed publisher
    ..Genetic risk score (GRS) were calculated using the weighted method. The Mediterranean dietary score (MDS) was computed...
  82. Roschanski N, Guenther S, Vu T, Fischer J, Semmler T, Huehn S, et al. VIM-1 carbapenemase-producing Escherichia coli isolated from retail seafood, Germany 2016. Euro Surveill. 2017;22: pubmed publisher
    ..These results confirm previous observations that carbapenemase-producing bacteria have reached the food chain and are of increasing concern for public health. ..
  83. Liu N, Li Z, Zhao N, Song Q, Zhu J, Yang B. Identification and characterization of chemosensory gene families in the bark beetle, Tomicus yunnanensis. Comp Biochem Physiol Part D Genomics Proteomics. 2018;25:73-85 pubmed publisher
    ..OBPs), 12 chemosensory proteins (CSPs), 20 receptor proteins [9 odorant receptors (ORs), 8 gustatory receptors (GRs) and 3 ionotropic receptors (IRs)] and 3 sensory neuron membrane proteins (SNMPs)...
  84. Mizojiri R, Asano M, Tomita D, Banno H, Nii N, Sasaki M, et al. Discovery of Novel Selective Acetyl-CoA Carboxylase (ACC) 1 Inhibitors. J Med Chem. 2017;: pubmed publisher
    We initiated our structure-activity relationship (SAR) studies for selective ACC1 inhibitors from 1a as a lead compound...
  85. Holmgreen S, Huang D, Adams J, Cory S. Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members. Cell Death Differ. 1999;6:525-32 pubmed
    ..The results may reflect critical threshold affinities but also suggest that certain pro-apoptotic proteins may also contribute to apoptosis by a mechanism independent of binding pro-survival proteins. ..
  86. Szapary D, Song L, He Y, Simons S. Differential modulation of glucocorticoid and progesterone receptor transactivation. Mol Cell Endocrinol. 2008;283:114-26 pubmed publisher
    ..The determinants of the different biological activities of progesterone receptors (PRs) vs. glucocorticoid receptors (GRs), which bind to the same DNA sequences, remain poorly understood...
  87. Huras H, Nowak M, Herman Sucharska I, Radon Pokracka M, Nocuń A, Wiecheć M. Screening performance for callosal agenesis in prenatal life. Single center study. Clin Imaging. 2017;46:116-120 pubmed publisher
    ..This case demonstrated partial ACC in neonatal MRI (nMRI). Sensitivity of second trimester scan for callosal agenesis of 73% and specificity of 99%. Prenatal MRI and US has similar amount of misdiagnoses. ..
  88. Xu W, Liu N, Liao Y, Anderson A. Molecular characterization of sugar taste receptors in the cotton bollworm Helicoverpa armigera. Genome. 2017;60:1037-1044 pubmed publisher
    ..armigera sugar GR sequences are conserved at C-terminus and phylogenetic analysis showed that insect sugar GRs have evolved in a family-specific manner. Interestingly, all eight H...
  89. Moon J, Wang T, Sofer T, North K, Isasi C, Cai J, et al. Objectively Measured Physical Activity, Sedentary Behavior, and Genetic Predisposition to Obesity in U.S. Hispanics/Latinos: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Diabetes. 2017;66:3001-3012 pubmed publisher
    ..S. Hispanics/Latinos. An overall genetic risk score (GRS), a central nervous system (CNS)-related GRS, and a non-CNS-related GRS were calculated based on 97 BMI-associated ..
  90. Nierenberg J, Li C, He J, Gu D, Chen J, Lu X, et al. Blood Pressure Genetic Risk Score Predicts Blood Pressure Responses to Dietary Sodium and Potassium: The GenSalt Study (Genetic Epidemiology Network of Salt Sensitivity). Hypertension. 2017;70:1106-1112 pubmed publisher
    We examined the association between genetic risk score (GRS) for blood pressure (BP), based on single nucleotide polymorphisms identified in previous BP genome-wide association study meta-analyses, and salt and potassium sensitivity of ..
  91. Marouli E, Kanoni S, Mamakou V, Hackinger S, Southam L, Prins B, et al. Evaluating the glucose raising effect of established loci via a genetic risk score. PLoS ONE. 2017;12:e0186669 pubmed publisher
    ..We developed a genetic risk score (GRS), based on the known glucose-raising loci, in order to investigate the cumulative effect of known glucose loci on ..
  92. Hüls A, Kramer U, CARLSTEN C, Schikowski T, Ickstadt K, Schwender H. Comparison of weighting approaches for genetic risk scores in gene-environment interaction studies. BMC Genet. 2017;18:115 pubmed publisher
    Weighted genetic risk scores (GRS), defined as weighted sums of risk alleles of single nucleotide polymorphisms (SNPs), are statistically powerful for detection gene-environment (GxE) interactions...