Bax

Summary

Gene Symbol: Bax
Description: BCL2 associated X, apoptosis regulator
Alias: BCL2L4, apoptosis regulator BAX, BCL2 associated X protein, BCL2-associated X protein omega, Baxdelta2G9, Baxdelta2G9omega, Baxdelta2omega, bcl-2-like protein 4, bcl2-L-4
Species: human
Products:     Bax

Top Publications

  1. Subramanian C, Jarzembowski J, Opipari A, Castle V, Kwok R. HDAC6 deacetylates Ku70 and regulates Ku70-Bax binding in neuroblastoma. Neoplasia. 2011;13:726-34 pubmed
    ..However, recent studies have shown that Ku70 is also found in the cytoplasm and binds Bax, preventing Bax-induced cell death...
  2. Laroche Pierre S, Jodoin J, LeBlanc A. Helix 3 is necessary and sufficient for prion protein's anti-Bax function. J Neurochem. 2009;108:1019-31 pubmed publisher
    ..elements of the prion protein (PrP) necessary for its protective function against Bcl-2 associated protein X (Bax), we performed structure-function analyses of the anti-Bax function of cytosolic PrP (CyPrP) in MCF-7 cells...
  3. McLean J, Datan E, Matassov D, Zakeri Z. Lack of Bax prevents influenza A virus-induced apoptosis and causes diminished viral replication. J Virol. 2009;83:8233-46 pubmed publisher
    ..Here we report that influenza A virus cannot establish an apoptotic response without functional Bax, a downstream target of Bcl-2, and that both Bax and Bak are directly involved in influenza A virus replication and ..
  4. Peng F, Dhillon N, Yao H, Zhu X, Williams R, Buch S. Mechanisms of platelet-derived growth factor-mediated neuroprotection--implications in HIV dementia. Eur J Neurosci. 2008;28:1255-64 pubmed publisher
    ..inducing phosphorylation of Bad, PDGF-mediated protection also involved down-regulation of the proapoptotic protein Bax. Furthermore, PDGF-mediated protection also involved the inhibition of gp120-induced release of mitochondrial ..
  5. Benard G, Neutzner A, Peng G, Wang C, Livak F, Youle R, et al. IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation. EMBO J. 2010;29:1458-71 pubmed publisher
    b>Bax, a pro-apoptotic protein from the Bcl-2 family, is central to apoptosis regulation. To suppress spontaneous apoptosis, Bax must be under stringent control that may include regulation of Bax conformation and expression levels...
  6. Montessuit S, Somasekharan S, Terrones O, Lucken Ardjomande S, Herzig S, Schwarzenbacher R, et al. Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization. Cell. 2010;142:889-901 pubmed publisher
    In response to many apoptotic stimuli, oligomerization of Bax is essential for mitochondrial outer membrane permeabilization and the ensuing release of cytochrome c...
  7. Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk J, Kuwana T. BH3 domains other than Bim and Bid can directly activate Bax/Bak. J Biol Chem. 2011;286:491-501 pubmed publisher
    ..Members of a subgroup of the Bcl-2 family, known as the BH3-only proteins, activate pro-apoptotic effectors (Bax and Bak) to initiate MOMP...
  8. Yin X, Cao L, Kang R, Yang M, Wang Z, Peng Y, et al. UV irradiation resistance-associated gene suppresses apoptosis by interfering with BAX activation. EMBO Rep. 2011;12:727-34 pubmed publisher
    ..Here, we present evidence that UVRAG functions as an unusual BCL2-associated X protein (Bax) suppressor to regulate apoptosis...
  9. Billen L, Kokoski C, Lovell J, Leber B, Andrews D. Bcl-XL inhibits membrane permeabilization by competing with Bax. PLoS Biol. 2008;6:e147 pubmed publisher
    Although Bcl-XL and Bax are structurally similar, activated Bax forms large oligomers that permeabilize the outer mitochondrial membrane, thereby committing cells to apoptosis, whereas Bcl-XL inhibits this process...

More Information

Publications68

  1. Leskov K, Araki S, Lavik J, Gomez J, Gama V, Gonos E, et al. CRM1 protein-mediated regulation of nuclear clusterin (nCLU), an ionizing radiation-stimulated, Bax-dependent pro-death factor. J Biol Chem. 2011;286:40083-90 pubmed publisher
    ..nCLU-mediated apoptosis was Bax-dependent, and lethality correlated with accumulation of mature nCLU protein...
  2. Sai T, Matsuda F, Goto Y, Maeda A, Sugimoto M, Gao H, et al. Effect of RNA interference of BID and BAX mRNAs on apoptosis in granulosa cell-derived KGN cells. J Reprod Dev. 2012;58:112-6 pubmed
    ..type II apoptosis, BH3-interacting domain death agonist (BID) and BCL-2-associated X protein (BAX) promote death ligand and receptor-mediated cell death...
  3. Liu Y, Luo W. Betulinic acid induces Bax/Bak-independent cytochrome c release in human nasopharyngeal carcinoma cells. Mol Cells. 2012;33:517-24 pubmed publisher
    ..Overexpression of Bcl-2 and Bcl-xL could partially prevent apoptosis caused by BetA. Moreover, Bax was not activated during the induction of apoptosis...
  4. Lopes Costa P, Dos Santos A, da Silva B. The effect of raloxifene on Bax protein expression in breast carcinomas of postmenopausal women. Diagn Cytopathol. 2012;40:570-4 pubmed publisher
    The actual role of Bax protein as a prognostic biomarker that predicts response to therapy remains unclear...
  5. Walensky L, Gavathiotis E. BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore. Trends Biochem Sci. 2011;36:642-52 pubmed publisher
    b>BAX, the BCL-2-associated X protein, is a cardinal proapoptotic member of the BCL-2 family, which regulates the critical balance between cellular life and death...
  6. Wang C, Youle R. Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak. Oncogene. 2012;31:3177-89 pubmed publisher
    The intrinsic mitochondrial apoptotic pathway acts through two core pro-apoptotic proteins Bax (Bcl2-associated X protein) and Bak (Bcl2-antagonist/killer 1)...
  7. Follis A, Llambi F, Ou L, Baran K, Green D, Kriwacki R. The DNA-binding domain mediates both nuclear and cytosolic functions of p53. Nat Struct Mol Biol. 2014;21:535-43 pubmed publisher
    Under conditions of genotoxic stress, human p53 activates the apoptotic effectors BAX or BAK to result in mitochondrial outer-membrane permeabilization and apoptosis...
  8. Ahmad R, Alam M, Rajabi H, Kufe D. The MUC1-C oncoprotein binds to the BH3 domain of the pro-apoptotic BAX protein and blocks BAX function. J Biol Chem. 2012;287:20866-75 pubmed publisher
    The pro-apoptotic BAX protein contains a BH3 domain that is necessary for its dimerization and for activation of the intrinsic apoptotic pathway...
  9. Kim E, Kim J, Park J, Hwang S, Kim W, Lee W, et al. Bcl-w promotes cell invasion by blocking the invasion-suppressing action of Bax. Cell Signal. 2012;24:1163-72 pubmed
    ..By way of contrast, Bax,a member of the multidomain pro-apoptotic group (Bax and Bak), was found to reduce ROS levels, thereby suppressing ..
  10. Bose P, Klimowicz A, Kornaga E, Petrillo S, Matthews T, Chandarana S, et al. Bax expression measured by AQUAnalysis is an independent prognostic marker in oral squamous cell carcinoma. BMC Cancer. 2012;12:332 pubmed publisher
    ..b>Bax, Bcl-2 and Bcl-XL protein expression was quantified using fluorescent IHC and AQUA technology in normal oral cavity ..
  11. Ganesan V, Perera M, Colombini D, Datskovskiy D, Chadha K, Colombini M. Ceramide and activated Bax act synergistically to permeabilize the mitochondrial outer membrane. Apoptosis. 2010;15:553-62 pubmed publisher
    ..Here, we demonstrate that Bax and ceramide induce MOMP synergistically...
  12. Rostovtseva T, Boukari H, Antignani A, Shiu B, Banerjee S, Neutzner A, et al. Bax activates endophilin B1 oligomerization and lipid membrane vesiculation. J Biol Chem. 2009;284:34390-9 pubmed publisher
    ..Endophilin B1 (Endo B1) was identified to bind Bax, a Bcl-2 family member that promotes apoptosis, through yeast two-hybrid protein screens...
  13. Dussmann H, Rehm M, Concannon C, Anguissola S, Würstle M, Kacmar S, et al. Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation. Cell Death Differ. 2010;17:278-90 pubmed publisher
    ..outer membrane permeabilisation (MOMP) during apoptosis is triggered by the activation and oligomerisation of Bax and Bak, but a quantification of these processes in individual cells has not yet been performed...
  14. Czabotar P, Westphal D, Dewson G, Ma S, Hockings C, Fairlie W, et al. Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis. Cell. 2013;152:519-31 pubmed publisher
    In stressed cells, apoptosis ensues when Bcl-2 family members Bax or Bak oligomerize and permeabilize the mitochondrial outer membrane. Certain BH3-only relatives can directly activate them to mediate this pivotal, poorly understood step...
  15. Gallenne T, Gautier F, Oliver L, Hervouet E, Noël B, Hickman J, et al. Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members. J Cell Biol. 2009;185:279-90 pubmed publisher
    ..BH3-binding Bcl-2 homologues necessary for survival through its ability to directly interact with proapoptotic Bax and activate it...
  16. Yao H, Allen J, Zhu X, Callen S, Buch S. Cocaine and human immunodeficiency virus type 1 gp120 mediate neurotoxicity through overlapping signaling pathways. J Neurovirol. 2009;15:164-75 pubmed publisher
    ..and gp120 was accompanied by an increase in both caspase-3 activity and expression of the proapoptotic protein Bax. Furthermore, increased neurotoxicity in the presence of both the agents was associated with a concomitant increase ..
  17. Westphal D, Kluck R, Dewson G. Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis. Cell Death Differ. 2014;21:196-205 pubmed publisher
    ..In this review we focus on the recent progress made in characterizing the proapoptotic Bcl-2 family members, Bax and Bak...
  18. Christenson E, Merlin S, Saito M, Schlesinger P. Cholesterol effects on BAX pore activation. J Mol Biol. 2008;381:1168-83 pubmed publisher
    ..One of the key members of this family, BAX, has soluble, membrane-bound, and membrane-integrated forms that are central to the regulation of apoptosis...
  19. Iijima K, Muranaka C, Kobayashi J, Sakamoto S, Komatsu K, Matsuura S, et al. NBS1 regulates a novel apoptotic pathway through Bax activation. DNA Repair (Amst). 2008;7:1705-16 pubmed publisher
    ..a series of cell lines expressing mutant NBS1 proteins revealed that NBS1 is able to regulate the activation of Bax and Caspase-3 without the FHA, Mre11-binding, or the ATM-interacting domains, whereas the phosphorylation sites of ..
  20. Trougakos I, Lourda M, Antonelou M, Kletsas D, Gorgoulis V, Papassideri I, et al. Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex. Clin Cancer Res. 2009;15:48-59 pubmed publisher
    ..In the cytoplasm, sCLU depletion disrupts the Ku70-Bax complex and triggers Bax activation and relocation to mitochondria...
  21. Lin D, Jodoin J, Baril M, Goodyer C, LeBlanc A. Cytosolic prion protein is the predominant anti-Bax prion protein form: exclusion of transmembrane and secreted prion protein forms in the anti-Bax function. Biochim Biophys Acta. 2008;1783:2001-12 pubmed publisher
    Prion protein (PrP) prevents Bax-mediated cell death by inhibiting the initial Bax conformational change that converts cytosolic Bax into a pro-apoptotic protein...
  22. Yigit S, Demir L, Tarhan M, Cabuk F, Ellidokuz H, Erten C, et al. The clinicopathological significance of Bax and Bcl-2 protein expression with tumor infiltrating lymphocytes in ovarian carcinoma. Neoplasma. 2012;59:475-85 pubmed publisher
    The aim of the study was to establish the prognostic and predictive value of Bax and Bcl-2 proteins in conjunction with the host immune response in primary epithelial ovarian carcinoma.83 patients were evaluated...
  23. Czabotar P, Lee E, Thompson G, Wardak A, Fairlie W, Colman P. Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis. J Biol Chem. 2011;286:7123-31 pubmed publisher
    Pro-survival members of the Bcl-2 family of proteins restrain the pro-apoptotic activity of Bax, either directly through interactions with Bax or indirectly by sequestration of activator BH3-only proteins, or both...
  24. Lin S, Perera M, Nguyen T, Datskovskiy D, Miles M, Colombini M. Bax forms two types of channels, one of which is voltage-gated. Biophys J. 2011;101:2163-9 pubmed publisher
    When activated, the proapoptotic protein Bax permeabilizes the mitochondrial outer membrane, allowing the release of proteins into the cytosol and thus initiating the execution phase of apoptosis...
  25. Upreti M, Galitovskaya E, Chu R, Tackett A, Terrano D, Granell S, et al. Identification of the major phosphorylation site in Bcl-xL induced by microtubule inhibitors and analysis of its functional significance. J Biol Chem. 2008;283:35517-25 pubmed publisher
    ..Co-immunoprecipitation revealed that phosphorylation caused wild-type Bcl-xL to release bound Bax, whereas phospho-defective Bcl-xL retained the ability to bind Bax...
  26. Gavathiotis E, Suzuki M, Davis M, Pitter K, Bird G, Katz S, et al. BAX activation is initiated at a novel interaction site. Nature. 2008;455:1076-81 pubmed publisher
    b>BAX is a pro-apoptotic protein of the BCL-2 family that is stationed in the cytosol until activated by a diversity of stress stimuli to induce cell death. Anti-apoptotic proteins such as BCL-2 counteract BAX-mediated cell death...
  27. Gillissen B, Wendt J, Richter A, Richter A, Müer A, Overkamp T, et al. Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma. J Cell Biol. 2010;188:851-62 pubmed publisher
    ..Thus, TRAIL-induced cell death entirely depends on the proapoptotic Bcl-2 family member Bax, which is often lost as a result of epigenetic inactivation or mutations...
  28. Gautier F, Guillemin Y, Cartron P, Gallenne T, Cauquil N, Le Diguarher T, et al. Bax activation by engagement with, then release from, the BH3 binding site of Bcl-xL. Mol Cell Biol. 2011;31:832-44 pubmed publisher
    ..sequestration of "activator" BH3-only proteins (such as Puma), preventing them from directly activating Bax. It is thus assumed that inhibition of interactions between activators and Bcl-x(L) is a prerequisite for small ..
  29. Ren H, Fu K, Wang D, Mu C, Wang G. Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL. J Biol Chem. 2011;286:35308-17 pubmed publisher
    ..to increases of Bcl-X(L) ubiquitination and degradation upon UVB irradiation, thereby increasing mitochondrial Bax, caspase-3 activation and PARP cleavage...
  30. Beltran E, Fresquet V, Martinez Useros J, Richter Larrea J, Sagardoy A, Sesma I, et al. A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma. Proc Natl Acad Sci U S A. 2011;108:12461-6 pubmed publisher
    ..through deregulation of the cell cycle at the G(1)-S transition, sequestrates the proapoptotic protein BAX in the cytoplasm, thereby favoring BCL2's antiapoptotic function...
  31. Nardiello T, Jungbluth A, Mei A, DiLiberto M, Huang X, Dabrowski A, et al. MAGE-A inhibits apoptosis in proliferating myeloma cells through repression of Bax and maintenance of survivin. Clin Cancer Res. 2011;17:4309-19 pubmed publisher
    ..Loss of MAGE-A led to apoptosis mediated by p53-dependent activation of proapoptotic Bax expression and by reduction of survivin expression through both p53-dependent and -independent mechanisms...
  32. Fu N, Sukumaran S, Kerk S, Yu V. Baxbeta: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism. Mol Cell. 2009;33:15-29 pubmed publisher
    Although mRNAs of multiple isoforms of Bax, which encodes a central regulator of apoptosis signaling, have been reported, only Baxalpha protein has been well documented and studied...
  33. Dewson G, Ma S, Frederick P, Hockings C, Tan I, Kratina T, et al. Bax dimerizes via a symmetric BH3:groove interface during apoptosis. Cell Death Differ. 2012;19:661-70 pubmed publisher
    During apoptotic cell death, Bax and Bak change conformation and homo-oligomerize to permeabilize mitochondria...
  34. Dumitru R, Gama V, Fagan B, Bower J, Swahari V, Pevny L, et al. Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosis. Mol Cell. 2012;46:573-83 pubmed publisher
    ..A critical mediator of apoptosis is Bax, which is reported to become active and translocate to the mitochondria only after apoptotic stimuli...
  35. Kushnareva Y, Andreyev A, Kuwana T, Newmeyer D. Bax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranes. PLoS Biol. 2012;10:e1001394 pubmed publisher
    b>Bax/Bak-mediated mitochondrial outer membrane permeabilization (MOMP) is essential for "intrinsic" apoptotic cell death...
  36. Sarosiek K, Chi X, Bachman J, Sims J, Montero J, Patel L, et al. BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response. Mol Cell. 2013;51:751-65 pubmed publisher
    ..death via the mitochondrial apoptotic pathway requires activation of the mitochondrial pore-forming proteins BAK or BAX. Activation can be effected by the activator BH3-only proteins BID or BIM, which have been considered to be ..
  37. Boohaker R, Zhang G, Carlson A, Nemec K, Khaled A. BAX supports the mitochondrial network, promoting bioenergetics in nonapoptotic cells. Am J Physiol Cell Physiol. 2011;300:C1466-78 pubmed publisher
    The dual functionality of the tumor suppressor BAX is implied by the nonapoptotic functions of other members of the BCL-2 family...
  38. Etxebarria A, Terrones O, Yamaguchi H, Landajuela A, Landeta O, Antonsson B, et al. Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements. J Biol Chem. 2009;284:4200-12 pubmed publisher
    Endophilin B1/BAX-interacting factor 1 (Bif-1) is a protein that cooperates with dynamin-like protein 1 (DLP1/Drp1) to maintain normal mitochondrial outer membrane (MOM) dynamics in healthy cells and also contributes to BAX-driven MOM ..
  39. Lovell J, Billen L, Bindner S, Shamas Din A, Fradin C, Leber B, et al. Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax. Cell. 2008;135:1074-84 pubmed publisher
    ..However, the rules of engagement between the pro- and antiapoptotic family members are still contested, and how Bax is transformed from a cytosolic monomer to an outer mitochondrial membrane-permeabilizing oligomer is unclear...
  40. Nehls O, Hass H, Okech T, Zenner S, Hsieh C, Sarbia M, et al. Prognostic implications of BAX protein expression and microsatellite instability in all non-metastatic stages of primary colon cancer treated by surgery alone. Int J Colorectal Dis. 2009;24:655-63 pubmed publisher
    This study examined whether the apoptosis-related protein, BAX, or the microsatellite-instability phenotype provide prognostic information in patients with resected colon cancer...
  41. Fletcher J, Meusburger S, Hawkins C, Riglar D, Lee E, Fairlie W, et al. Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax. Proc Natl Acad Sci U S A. 2008;105:18081-7 pubmed publisher
    A central issue in the control of apoptosis is whether its essential mediators Bax and Bak must be restrained by Bcl-2-like prosurvival relatives to prevent their damaging mitochondria and unleashing apoptosis...
  42. Sinha S, Malonia S, Mittal S, Singh K, Kadreppa S, Kamat R, et al. Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element. EMBO J. 2010;29:830-42 pubmed publisher
    ..We show that BAX and PUMA promoters harbour an identical MAR element and are transcriptional targets of SMAR1...
  43. Adams S, Aksenova M, Aksenov M, Mactutus C, Booze R. ER-? mediates 17?-estradiol attenuation of HIV-1 Tat-induced apoptotic signaling. Synapse. 2010;64:829-38 pubmed publisher
    ..with 17?-estradiol (10 nM) attenuated the increased expression of antiapoptotic protein Bcl-2, proapoptotic protein Bax and activation of caspases linked to mitochondrial apoptotic pathway following Tat exposure...
  44. Edlich F, Banerjee S, Suzuki M, Cleland M, Arnoult D, Wang C, et al. Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol. Cell. 2011;145:104-16 pubmed publisher
    The Bcl-2 family member Bax translocates from the cytosol to mitochondria, where it oligomerizes and permeabilizes the mitochondrial outer membrane to promote apoptosis...
  45. Kolluri S, Zhu X, Zhou X, Lin B, Chen Y, Sun K, et al. A short Nur77-derived peptide converts Bcl-2 from a protector to a killer. Cancer Cell. 2008;14:285-98 pubmed publisher
    ..The apoptotic effect of NuBCPs and their activation of Bax are not inhibited but rather potentiated by Bcl-2...
  46. Lalier L, Cartron P, Olivier C, Loge C, Bougras G, Robert J, et al. Prostaglandins antagonistically control Bax activation during apoptosis. Cell Death Differ. 2011;18:528-37 pubmed publisher
    The Bax protein (Bcl-2-associated X protein) is pivotal for the apoptotic process...
  47. Gavathiotis E, Reyna D, Davis M, Bird G, Walensky L. BH3-triggered structural reorganization drives the activation of proapoptotic BAX. Mol Cell. 2010;40:481-92 pubmed publisher
    b>BAX is a proapoptotic BCL-2 family member that lies dormant in the cytosol until converted into a killer protein in response to cellular stress...
  48. Kashkar H, Wiegmann K, Yazdanpanah B, Haubert D, Kronke M. Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane. J Biol Chem. 2005;280:20804-13 pubmed
    ..Here we show that the UV light-induced apoptotic signaling pathway is unique, targeting Bax activation at the mitochondrial membrane independent of caspase-8 or cathepsin D activity...
  49. Lin B, Kolluri S, Lin F, Liu W, Han Y, Cao X, et al. Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell. 2004;116:527-40 pubmed
  50. Ming L, Wang P, Bank A, Yu J, Zhang L. PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells. J Biol Chem. 2006;281:16034-42 pubmed
    ..PUMA interacts with anti-apoptotic Bcl-2 and Bcl-X(L) and is dependent on Bax to induce apoptosis...
  51. Narita M, Shimizu S, Ito T, Chittenden T, Lutz R, Matsuda H, et al. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Acad Sci U S A. 1998;95:14681-6 pubmed
    ..Using isolated mitochondria, we found that recombinant Bax and Bak, proapoptotic members of the Bcl-2 family, induced mitochondrial Deltapsi loss, swelling, and cytochrome c ..
  52. Nomura M, Shimizu S, Sugiyama T, Narita M, Ito T, Matsuda H, et al. 14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax. J Biol Chem. 2003;278:2058-65 pubmed
    ..Pro-apoptotic members possessing BH1, BH2, and BH3 domains (such as Bax and Bak) act as a gateway for a variety of apoptotic signals...
  53. Shimizu S, Narita M, Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature. 1999;399:483-7 pubmed
    ..also called the voltage-dependent anion channel, or VDAC) to show that the recombinant pro-apoptotic proteins Bax and Bak accelerate the opening of VDAC, whereas the anti-apoptotic protein Bcl-x(L) closes VDAC by binding to it ..
  54. Meijerink J, Mensink E, Wang K, Sedlak T, Sloetjes A, de Witte T, et al. Hematopoietic malignancies demonstrate loss-of-function mutations of BAX. Blood. 1998;91:2991-7 pubmed
    ..Recently, studies of Bax-deficient mice have indicated that the pro-apoptotic BAX molecule can function as a tumor suppressor...
  55. Kashkar H, Kronke M, Jurgensmeier J. Defective Bax activation in Hodgkin B-cell lines confers resistance to staurosporine-induced apoptosis. Cell Death Differ. 2002;9:750-7 pubmed
    ..Correspondingly, activation of caspases was not observed in these cells. In staurosporine-treated Hodgkin cells Bax remained in its inactive state, indicating that these cell lines have a defect in this crucial step in apoptotic ..
  56. Ghatan S, Larner S, Kinoshita Y, Hetman M, Patel L, Xia Z, et al. p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. J Cell Biol. 2000;150:335-47 pubmed
    ..was further substantiated by the observation that SB203580 blocked translocation of the cell death activator, Bax, from the cytosol to the mitochondria after treatment with SNP...
  57. Kagawa S, Gu J, Honda T, McDonnell T, Swisher S, Roth J, et al. Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death. Clin Cancer Res. 2001;7:1474-80 pubmed
    ..cells and clones stably transfected with the caspase-3 gene (MCF7/Casp3), we evaluated the role of caspase-3 in Bax-induced apoptosis. Bax overexpression induced cell death in both parental MCF7 cells and MCF7/Casp3 cells...
  58. Roucou X, Guo Q, Zhang Y, Goodyer C, LeBlanc A. Cytosolic prion protein is not toxic and protects against Bax-mediated cell death in human primary neurons. J Biol Chem. 2003;278:40877-81 pubmed
    ..not only is microinjection of a cDNA construct expressing CyPrP not toxic, it protects these neurons against Bax-mediated cell death...
  59. Postigo A, Cross J, Downward J, Way M. Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis. Cell Death Differ. 2006;13:1651-62 pubmed
    ..As a consequence, F1L prevents Bak activation, oligomerization and interaction with active Bax, all critical steps in the induction of apoptosis...