BAP1

Summary

Gene Symbol: BAP1
Description: BRCA1 associated protein 1
Alias: HUCEP-13, UCHL2, hucep-6, ubiquitin carboxyl-terminal hydrolase BAP1, BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), cerebral protein 6, cerebral protein-13
Species: human
Products:     BAP1

Top Publications

  1. Ventii K, Devi N, Friedrich K, Chernova T, Tighiouart M, Van Meir E, et al. BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization. Cancer Res. 2008;68:6953-62 pubmed publisher
    BRCA1-associated protein-1 (BAP1), a deubiquitinating enzyme of unknown cellular function, is mutated in breast and lung cancers...
  2. Wiesner T, Murali R, Fried I, Cerroni L, Busam K, Kutzner H, et al. A distinct subset of atypical Spitz tumors is characterized by BRAF mutation and loss of BAP1 expression. Am J Surg Pathol. 2012;36:818-30 pubmed publisher
    We recently reported that germline mutations in BAP1 cause a familial tumor syndrome characterized by high penetrance for melanocytic tumors with distinct clinical and histologic features...
  3. Nishikawa H, Wu W, Koike A, Kojima R, Gomi H, Fukuda M, et al. BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity. Cancer Res. 2009;69:111-9 pubmed publisher
    ..BRCA1-associated protein 1 (BAP1) is a ubiquitin COOH-terminal hydrolase that was initially identified as a protein that bound to the RING finger ..
  4. Misaghi S, Ottosen S, Izrael Tomasevic A, Arnott D, Lamkanfi M, Lee J, et al. Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1. Mol Cell Biol. 2009;29:2181-92 pubmed publisher
    ..BRCA1-associated protein-1 (Bap1) is a ubiquitin carboxy-terminal hydrolase and is frequently mutated in lung and sporadic breast tumors...
  5. Höiom V, Edsgard D, Helgadottir H, Eriksson H, All Ericsson C, Tuominen R, et al. Hereditary uveal melanoma: a report of a germline mutation in BAP1. Genes Chromosomes Cancer. 2013;52:378-84 pubmed publisher
    ..Exome-wide analysis identified a novel loss-of-function mutation in the BAP1 gene, previously suggested as a tumor suppressor...
  6. Matatall K, Agapova O, Onken M, Worley L, Bowcock A, Harbour J. BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma. BMC Cancer. 2013;13:371 pubmed publisher
    ..melanomas, which exhibit a class 2 gene expression profile, contain inactivating mutations in the tumor suppressor BAP1. The aim of this study was to investigate the role of BAP1 in uveal melanoma progression...
  7. Fang Y, Fu D, Shen X. The potential role of ubiquitin c-terminal hydrolases in oncogenesis. Biochim Biophys Acta. 2010;1806:1-6 pubmed publisher
    ..hydrolases (UCHs) subfamily of DUBs consists of four members: UCH-L1, UCH-L3, UCH37 and BRCA1-associated protein-1 (BAP1)...
  8. Machida Y, Machida Y, Vashisht A, Wohlschlegel J, Dutta A. The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1. J Biol Chem. 2009;284:34179-88 pubmed publisher
    The deubiquitinating enzyme BRCA1-associated protein 1 (BAP1) possesses growth inhibitory activity and functions as a tumor suppressor. In this study we report that BAP1 also plays positive roles in cell proliferation...
  9. Peña Llopis S, Vega Rubin de Celis S, Liao A, Leng N, Pavía Jiménez A, Wang S, et al. BAP1 loss defines a new class of renal cell carcinoma. Nat Genet. 2012;44:751-9 pubmed publisher
    ..accurately determine mutant allele ratios) identified several putative two-hit tumor suppressor genes, including BAP1. The BAP1 protein, a nuclear deubiquitinase, is inactivated in 15% of clear cell RCCs...

More Information

Publications107 found, 100 shown here

  1. Njauw C, Kim I, Piris A, Gabree M, Taylor M, Lane A, et al. Germline BAP1 inactivation is preferentially associated with metastatic ocular melanoma and cutaneous-ocular melanoma families. PLoS ONE. 2012;7:e35295 pubmed publisher
    b>BAP1 has been shown to be a target of both somatic alteration in high-risk ocular melanomas (OM) and germline inactivation in a few individuals from cancer-prone families...
  2. Harbour J, Onken M, Roberson E, Duan S, Cao L, Worley L, et al. Frequent mutation of BAP1 in metastasizing uveal melanomas. Science. 2010;330:1410-3 pubmed publisher
    ..Inactivating somatic mutations were identified in the gene encoding BRCA1-associated protein 1 (BAP1) on chromosome 3p21...
  3. Wiesner T, Obenauf A, Murali R, Fried I, Griewank K, Ulz P, et al. Germline mutations in BAP1 predispose to melanocytic tumors. Nat Genet. 2011;43:1018-21 pubmed publisher
    ..Segregating with this phenotype, we found inactivating germline mutations of BAP1, which encodes a ubiquitin carboxy-terminal hydrolase...
  4. Abdel Wahab O, Dey A. The ASXL-BAP1 axis: new factors in myelopoiesis, cancer and epigenetics. Leukemia. 2013;27:10-5 pubmed publisher
    The recent identification of germline and somatic mutations in BAP1 as well as in multiple members of the ASXL (additional sex combs-like) family of genes has highlighted the role of these proteins in a diverse array of biological ..
  5. Yu H, Mashtalir N, Daou S, Hammond Martel I, Ross J, Sui G, et al. The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. Mol Cell Biol. 2010;30:5071-85 pubmed publisher
    The candidate tumor suppressor BAP1 is a deubiquitinating enzyme (DUB) involved in the regulation of cell proliferation, although the molecular mechanisms governing its function remain poorly defined...
  6. Bott M, Brevet M, Taylor B, Shimizu S, Ito T, Wang L, et al. The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma. Nat Genet. 2011;43:668-72 pubmed publisher
    ..of 53 MPM tumor samples to guide a focused sequencing effort that uncovered somatic inactivating mutations in BAP1 in 23% of MPMs...
  7. Scheuermann J, de Ayala Alonso A, Oktaba K, Ly Hartig N, McGinty R, Fraterman S, et al. Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature. 2010;465:243-7 pubmed publisher
    ..Here we show that the uncharacterized Drosophila PcG gene calypso encodes the ubiquitin carboxy-terminal hydrolase BAP1. Biochemically purified Calypso exists in a complex with the PcG protein ASX, and this complex, named Polycomb ..
  8. Abdel Rahman M, Pilarski R, Cebulla C, Massengill J, Christopher B, Boru G, et al. Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers. J Med Genet. 2011;48:856-9 pubmed publisher
    To investigate the potential contribution of germline sequence alterations in the BAP1 gene in uveal melanoma (UM) patients with possible predisposition to hereditary cancer...
  9. Testa J, Cheung M, Pei J, Below J, Tan Y, Sementino E, et al. Germline BAP1 mutations predispose to malignant mesothelioma. Nat Genet. 2011;43:1022-5 pubmed publisher
    ..We discovered germline mutations in the gene encoding BRCA1 associated protein-1 (BAP1) in two families with a high incidence of mesothelioma, and we observed somatic alterations affecting BAP1 in ..
  10. Kapur P, Peña Llopis S, Christie A, Zhrebker L, Pavía Jiménez A, Rathmell W, et al. Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation. Lancet Oncol. 2013;14:159-167 pubmed publisher
    ..However, the molecular genetic events driving these behaviours are unknown. We discovered that BAP1 is mutated in about 15% of clear-cell renal-cell carcinoma, and that BAP1 and PBRM1 mutations are largely mutually ..
  11. Jensen D, Proctor M, Marquis S, Gardner H, Ha S, Chodosh L, et al. BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. Oncogene. 1998;16:1097-112 pubmed
    We have identified a novel protein, BAP1, which binds to the RING finger domain of the Breast/Ovarian Cancer Susceptibility Gene product, BRCA1...
  12. Carbone M, Ferris L, Baumann F, Napolitano A, Lum C, Flores E, et al. BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs. J Transl Med. 2012;10:179 pubmed publisher
    BRCA1-associated protein 1 (BAP1) is a tumor suppressor gene located on chromosome 3p21...
  13. Eletr Z, Wilkinson K. An emerging model for BAP1's role in regulating cell cycle progression. Cell Biochem Biophys. 2011;60:3-11 pubmed publisher
    BRCA1-associated protein-1 (BAP1) is a 729 residue, nuclear-localized deubiquitinating enzyme (DUB) that displays tumor suppressor properties in the BAP1-null NCI-H226 lung carcinoma cell line...
  14. Shah F, Park D, Koh P. Identification of Proteins Differentially Expressed by Quercetin Treatment in a Middle Cerebral Artery Occlusion Model: A Proteomics Approach. Neurochem Res. 2018;43:1608-1623 pubmed publisher
    ..These results suggest that quercetin reduces ischemic injury by modulating the expression of various proteins in focal cerebral ischemia. ..
  15. Menon K, Steer D, Short M, Petratos S, Smith I, Bernard C. A novel unbiased proteomic approach to detect the reactivity of cerebrospinal fluid in neurological diseases. Mol Cell Proteomics. 2011;10:M110.000042 pubmed publisher
  16. Vansandt L, Livesay J, Dickson M, Li L, Pukazhenthi B, Keefer C. Conservation of spermatogonial stem cell marker expression in undifferentiated felid spermatogonia. Theriogenology. 2016;86:1022-1035.e3 pubmed publisher
    ..These markers will facilitate further studies in cell enrichment and IVC of felid SSCs enabling both production of transgenic domestic cats and preservation of the male genome from rare and endangered felids. ..
  17. Blyth B, Farahvar A, He H, Nayak A, Yang C, Shaw G, et al. Elevated serum ubiquitin carboxy-terminal hydrolase L1 is associated with abnormal blood-brain barrier function after traumatic brain injury. J Neurotrauma. 2011;28:2453-62 pubmed publisher
    ..We conclude that peripheral release of S100B after multi-trauma is probably negligible and that UCHL1 may have some utility to monitor BBB disruption following TBI. ..
  18. Zheng S, Qiao G, Min D, Zhang Z, Lin F, Yang Q, et al. Heterogeneous expression and biological function of ubiquitin carboxy-terminal hydrolase-L1 in osteosarcoma. Cancer Lett. 2015;359:36-46 pubmed publisher
    ..Finally, in vivo data showed that knockdown of UCHL1 inhibited osteosarcoma growth in nude mice. These results indicate that UCHL1 could work as an oncogene and may serve as a promising therapeutic strategy for osteosarcoma. ..
  19. Shah F, Gim S, Sung J, Jeon S, Kim M, Koh P. Identification of proteins regulated by curcumin in cerebral ischemia. J Surg Res. 2016;201:141-8 pubmed publisher
    ..The results of this study suggest that curcumin exerts a neuroprotective effect by regulating the expression of various proteins in focal cerebral ischemia. ..
  20. Zhang H, Sun Y, Hu R, Luo W, Mao X, Zhao Z, et al. The regulation of the UCH-L1 gene by transcription factor NF-κB in podocytes. Cell Signal. 2013;25:1574-85 pubmed publisher
  21. Jin Y, Zhang W, Xu J, Wang H, Zhang Z, Chu C, et al. UCH-L1 involved in regulating the degradation of EGFR and promoting malignant properties in drug-resistant breast cancer. Int J Clin Exp Pathol. 2015;8:12500-8 pubmed
    ..Our findings suggest that UCH-L1 may be an indicator of chemotherapy-response and poor-survival in breast cancer. UCH-L1 might be an appropriate target for improving chemo-resistant breast cancer therapy. ..
  22. Cheng J, Tseng C, Liao M, Peng C, Yu J, Chuang P, et al. Activation of hepatic stellate cells by the ubiquitin C-terminal hydrolase 1 protein secreted from hepatitis C virus-infected hepatocytes. Sci Rep. 2017;7:4448 pubmed publisher
    ..These results provide further for understanding the underlying mechanism in HCV-mediated hepatic fibrogenesis. ..
  23. Massaro A, Wu Y, Bammler T, Comstock B, Mathur A, McKinstry R, et al. Plasma Biomarkers of Brain Injury in Neonatal Hypoxic-Ischemic Encephalopathy. J Pediatr. 2018;194:67-75.e1 pubmed publisher
    ..Only Tau and BDNF levels were found to be related to neurodevelopmental outcomes. The effect of Epo treatment on the relationships between biomarkers and brain injury in HIE requires further study. ClinicalTrials.gov: 01913340. ..
  24. Genç B, Lagrimas A, Kuru P, Hess R, Tu M, Menichella D, et al. Visualization of Sensory Neurons and Their Projections in an Upper Motor Neuron Reporter Line. PLoS ONE. 2015;10:e0132815 pubmed publisher
  25. Zhang L, Shen C, Chu J, Liu Y, Li Y, Zhang L, et al. Icariin reduces α-synuclein over-expression by promoting α-synuclein degradation. Age (Dordr). 2015;37:9811 pubmed publisher
    ..It is suggested that icariin may have the potential to treat Alzheimer's disease (AD) and other synucleinopathies. ..
  26. Gao D, Wu M, Wang C, Wang Y, Zuo Z. Chronic exposure to low benzo[a]pyrene level causes neurodegenerative disease-like syndromes in zebrafish (Danio rerio). Aquat Toxicol. 2015;167:200-8 pubmed publisher
    ..This study provides clues that BaP may constitute an important environmental risk factor for neurodegenerative diseases in humans. ..
  27. Kapur P, Christie A, Raman J, Then M, Nuhn P, Buchner A, et al. BAP1 immunohistochemistry predicts outcomes in a multi-institutional cohort with clear cell renal cell carcinoma. J Urol. 2014;191:603-10 pubmed publisher
    Mutations in the tumor suppressor gene BAP1 occur in approximately 15% of clear cell renal cell carcinoma cases. Sequencing efforts demonstrated worse outcomes in patients with BAP1 mutated clear cell renal cell carcinoma...
  28. Kalra N, Zhang J, Thomas A, Xi L, Cheung M, Talarchek J, et al. Mesothelioma patient derived tumor xenografts with defined BAP1 mutations that mimic the molecular characteristics of human malignant mesothelioma. BMC Cancer. 2015;15:376 pubmed publisher
    ..Mutations of BAP1 and CDKN2A were each detected in four tumors...
  29. Mäki Nevala S, Sarhadi V, Knuuttila A, Scheinin I, Ellonen P, Lagström S, et al. Driver Gene and Novel Mutations in Asbestos-Exposed Lung Adenocarcinoma and Malignant Mesothelioma Detected by Exome Sequencing. Lung. 2016;194:125-35 pubmed
    ..PIK3CA, STK11, and ephrin receptor genes (EPHA1-8, 10 and EPHB1-4, 6) were studied for both LAC and MM, and in BAP1, CUL1, CDKN2A, and NF2 for MM...
  30. Fang Y, Shen X. Ubiquitin carboxyl-terminal hydrolases: involvement in cancer progression and clinical implications. Cancer Metastasis Rev. 2017;36:669-682 pubmed publisher
    ..5 (protein gene product 9.5), UCH-L3, UCHL5/UCH37, and BRCA1-associated protein-1 (BAP1)...
  31. Pulford E, Huilgol K, Moffat D, Henderson D, Klebe S. Malignant Mesothelioma, BAP1 Immunohistochemistry, and VEGFA: Does BAP1 Have Potential for Early Diagnosis and Assessment of Prognosis?. Dis Markers. 2017;2017:1310478 pubmed publisher
    ..Early diagnosis and accurate prognostication remain problematic. BAP1 is a tumour suppressor gene commonly mutated in MM...
  32. De Rienzo A, Archer M, Yeap B, Dao N, Sciaranghella D, Sideris A, et al. Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma. Cancer Res. 2016;76:319-28 pubmed publisher
    ..Specifically, single-nucleotide variants of BAP1 were observed in 21% of cases, with lower mutation rates observed in sarcomatoid MPM (P < 0.001)...
  33. Costa S, Byrne M, Pissaloux D, Haddad V, Paindavoine S, Thomas L, et al. Melanomas Associated With Blue Nevi or Mimicking Cellular Blue Nevi: Clinical, Pathologic, and Molecular Study of 11 Cases Displaying a High Frequency of GNA11 Mutations, BAP1 Expression Loss, and a Predilection for the Scalp. Am J Surg Pathol. 2016;40:368-77 pubmed publisher
    ..In uveal melanomas, monosomy 3, linked to the BAP1 gene, is an adverse prognostic factor...
  34. Vivancos A, Caratù G, Matito J, Munoz E, Ferrer B, Hernandez Losa J, et al. Genetic evolution of nevus of Ota reveals clonal heterogeneity acquiring BAP1 and TP53 mutations. Pigment Cell Melanoma Res. 2016;29:247-53 pubmed publisher
    ..Whole-exome sequencing of these lesions revealed the acquisition of BAP1 and TP53 mutations during tumor evolution, thereby unmasking clonal heterogeneity and allowing the identification ..
  35. Xie H, Wu J. Silica nanoparticles induce alpha-synuclein induction and aggregation in PC12-cells. Chem Biol Interact. 2016;258:197-204 pubmed publisher
    ..Our findings indicate that SiO2-NPs exposure induces neurotoxicity and may be a significant risk factor for the development of PD. ..
  36. Herrera C, Voisin M, Escalante T, Rucavado A, Nourshargh S, Gutierrez J. Effects of PI and PIII Snake Venom Haemorrhagic Metalloproteinases on the Microvasculature: A Confocal Microscopy Study on the Mouse Cremaster Muscle. PLoS ONE. 2016;11:e0168643 pubmed publisher
    ..In the present study, we compared the effects induced by BaP1, a PI SVMP isolated from Bothrops asper venom, and CsH1, a PIII SVMP from Crotalus simus venom, on cremaster muscle ..
  37. Miura Y, Inoshita N, Ikeda M, Miyama Y, Oki R, Oka S, et al. Loss of BAP1 protein expression in the first metastatic site predicts prognosis in patients with clear cell renal cell carcinoma. Urol Oncol. 2017;35:386-391 pubmed publisher
    To investigate the intratumoral heterogeneity of BAP1 and PBRM1 expression at the primary site and metastatic sites and to evaluate whether BAP1 and PBRM1 expression in metastatic sites of clear cell renal cell carcinoma (ccRCC) has ..
  38. Snezhkina A, Lukyanova E, Kalinin D, Pokrovsky A, Dmitriev A, Koroban N, et al. Exome analysis of carotid body tumor. BMC Med Genomics. 2018;11:17 pubmed publisher
    ..Exome analysis of 52 CBTs revealed potential driver mutations (PDMs) in 21 genes: ARNT, BAP1, BRAF, BRCA1, BRCA2, CDKN2A, CSDE1, FGFR3, IDH1, KIF1B, KMT2D, MEN1, RET, SDHA, SDHB, SDHC, SDHD, SETD2, TP53BP1, ..
  39. Bi M, Zhao S, Said J, Merino M, Adeniran A, Xie Z, et al. Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma. Proc Natl Acad Sci U S A. 2016;113:2170-5 pubmed publisher
    ..Mutations in known cancer drivers AT-rich interaction domain 1A (ARID1A) and BRCA1 associated protein 1 (BAP1) were significantly mutated in sarcomatoid elements and were mutually exclusive with TP53 and each other...
  40. Wiesner T, Kutzner H, Cerroni L, Mihm M, Busam K, Murali R. Genomic aberrations in spitzoid melanocytic tumours and their implications for diagnosis, prognosis and therapy. Pathology. 2016;48:113-31 pubmed publisher
    ..harbour BRAF mutations, NRAS mutations, or inactivation of NF1, Spitz tumours show HRAS mutations, inactivation of BAP1 (often combined with BRAF mutations), or genomic rearrangements involving the kinases ALK, ROS1, NTRK1, BRAF, RET, ..
  41. Duerksen Hughes P, Williamson M, Wilkinson K. Affinity chromatography using protein immobilized via arginine residues: purification of ubiquitin carboxyl-terminal hydrolases. Biochemistry. 1989;28:8530-6 pubmed
    ..Significant purification was achieved in each case, and one isozyme was further purified to homogeneity. ..
  42. Zhang X, Xi S, Sai K, Chen H, Zhong Z, Wu Q, et al. Cytoplasmic expression of BAP1 as an independent prognostic biomarker for patients with gliomas. Int J Clin Exp Pathol. 2015;8:5035-43 pubmed
    BRCA1-associated protein-1 (BAP1) has been investigated the prognostic value for some carcinomas, including mammary carcinoma, pulmonary carcinoma and mesothelioma and so on...
  43. Smith D, Maestre Reyna M, Lee G, Gerard H, Wang A, Watnick P. In situ proteolysis of the Vibrio cholerae matrix protein RbmA promotes biofilm recruitment. Proc Natl Acad Sci U S A. 2015;112:10491-6 pubmed publisher
    ..Proteins associated with the matrix include, RbmA, RbmC, and Bap1. RbmA, a protein whose crystallographic structure suggests two binding surfaces, associates with cells by means of ..
  44. Soura E, Eliades P, Shannon K, Stratigos A, Tsao H. Hereditary melanoma: Update on syndromes and management: Emerging melanoma cancer complexes and genetic counseling. J Am Acad Dermatol. 2016;74:411-20; quiz 421-2 pubmed publisher
    ..In addition to CDKN2A and CDK4, germline variants in TERT, MITF, and BAP1 have been added to the list of genes harboring melanoma-predisposing mutations...
  45. Zhang H, Luo W, Sun Y, Qiao Y, Zhang L, Zhao Z, et al. Wnt/?-Catenin Signaling Mediated-UCH-L1 Expression in Podocytes of Diabetic Nephropathy. Int J Mol Sci. 2016;17: pubmed publisher
    ..All the findings manifested that Wnt/?-catenin/UCH-L1 may be a new potential therapy method in the treatment of DN in future. ..
  46. Cozzi I, Oprescu F, Rullo E, Ascoli V. Loss of BRCA1-associated protein 1 (BAP1) expression is useful in diagnostic cytopathology of malignant mesothelioma in effusions. Diagn Cytopathol. 2017;: pubmed publisher
    ..Here, we evaluated the diagnostic utility of BAP1 immunohistochemistry (IHC) in distinguishing between reactive and neoplastic mesothelial cells.
  47. Raskin L, Guo Y, Du L, Clendenning M, Rosty C, Lindor N, et al. Targeted sequencing of established and candidate colorectal cancer genes in the Colon Cancer Family Registry Cohort. Oncotarget. 2017;8:93450-93463 pubmed publisher
    ..genes MLH1, APC, and POLE, and likely pathogenic variants in cancer susceptibility genes BAP1, CDH1, CHEK2, ENG, and MSH3...
  48. Field M, Durante M, Anbunathan H, Cai L, Decatur C, Bowcock A, et al. Punctuated evolution of canonical genomic aberrations in uveal melanoma. Nat Commun. 2018;9:116 pubmed publisher
    ..UM) is the most common primary eye cancer and frequently leads to metastatic death, which is strongly linked to BAP1 mutations. Accordingly, UM is ideally suited for studying the clonal evolution of metastatic competence...
  49. Rusch A, Ziltener G, Nackaerts K, Weder W, Stahel R, Felley Bosco E. Prevalence of BRCA-1 associated protein 1 germline mutation in sporadic malignant pleural mesothelioma cases. Lung Cancer. 2015;87:77-9 pubmed publisher
    23% of mesothelioma tumor specimens have a mutation in the BRCA1-associated protein 1 (BAP1) gene and germline BAP1 mutations predispose to malignant pleural mesothelioma (MPM)...
  50. Field M, Durante M, Decatur C, Tarlan B, Oelschlager K, Stone J, et al. Epigenetic reprogramming and aberrant expression of PRAME are associated with increased metastatic risk in Class 1 and Class 2 uveal melanomas. Oncotarget. 2016;7:59209-59219 pubmed publisher
    ..Analyses included PRAME mRNA expression, Class 1 versus Class 2 status, chromosomal copy number, mutation status of BAP1, EIF1AX, GNA11, GNAQ and SF3B1, and genomic DNA methylation status...
  51. Leung J, Kim W. Bap1 and Pbrm1: Determinants of Tumor Grade and mTOR Activation in VHL-Deficient Mouse Models of Renal Cell Carcinoma. Cancer Discov. 2017;7:802-804 pubmed publisher
    ..sequencing efforts have identified frequent mutations in the histone-modifying and chromatin-remodeling genes BAP1 and PBRM1 in clear cell renal cell carcinoma (ccRCC)...
  52. Mehdi A, Riazalhosseini Y. Epigenome Aberrations: Emerging Driving Factors of the Clear Cell Renal Cell Carcinoma. Int J Mol Sci. 2017;18: pubmed publisher
    ..of genes coding for epigenome modifiers and chromatin remodelers, including PBRM1, SETD2 and BAP1, are the most common somatic genetic abnormalities after VHL mutations in these tumors...
  53. Lorente L. Biomarkers Associated with the Outcome of Traumatic Brain Injury Patients. Brain Sci. 2017;7: pubmed publisher
  54. Hedayat A, Linos K, Jung H, Tafe L, Yan S, LeBlanc R, et al. Evaluating melanocytic lesions with single nucleotide polymorphism (SNP) chromosomal microarray. Exp Mol Pathol. 2017;103:279-287 pubmed publisher
    ..Eleven archival melanocytic lesions, including three benign nevi, four melanomas, three BAP1-deficient Spitzoid nevi and one nevoid melanoma were selected for validation...
  55. Behrends U, Schneider I, Rössler S, Frauenknecht H, Golbeck A, Lechner B, et al. Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. Int J Cancer. 2003;106:244-51 pubmed
    ..KIAA0445, KIAA1853, KIAA0665, FLJ13942, HSPC213), a proto-oncogene (rab18), candidate tumor suppressor genes (BAP1, PRDM13) and genes encoding a motor protein (kinesin-2), a histone (H2A1...
  56. Aoude L, Wadt K, Bojesen A, Cruger D, Borg A, Trent J, et al. A BAP1 mutation in a Danish family predisposes to uveal melanoma and other cancers. PLoS ONE. 2013;8:e72144 pubmed publisher
    Truncating germline mutations in the tumor suppressor gene BRCA-1 associated protein-1 (BAP1) have been reported in families predisposed to developing a wide range of different cancer types including uveal melanoma and cutaneous melanoma...
  57. Oumi N, Itamochi H, Komatsu H, Oishi T, Shimada M, Sato S, et al. Establishment and mutation analysis of a novel malignant peritoneal mesothelioma cell line, TU-MM-1, using whole genome sequencing. Hum Cell. 2016;29:46-51 pubmed publisher
    ..TU-MM-1 cells harbored missense mutations in APC, LATS2, BRCA1/2, and TP53, and mutation of a splice donor site in BAP1 and loss of CDKN2A gene...
  58. He Y, Zhang H, Li H, Zhang Y, Jia Q, Li Z, et al. Differential Proteomics Reveals the Potential Injury Mechanism Induced by Heavy Ion Radiation in Mice Ovaries. Biomed Environ Sci. 2017;30:301-307 pubmed publisher
    ..The proteomics and biochemical results provide insight into the underlying mechanisms of CIR toxicity in ovarian tissues. ..
  59. Zarrizi R, Menard J, Belting M, Massoumi R. Deubiquitination of γ-tubulin by BAP1 prevents chromosome instability in breast cancer cells. Cancer Res. 2014;74:6499-508 pubmed publisher
    ..In the current study, we identified BRCA1-associated protein-1 (BAP1) as a deubiquitination enzyme for γ-tubulin...
  60. Cebulla C, Binkley E, Pilarski R, Massengill J, Rai K, Liebner D, et al. Analysis of BAP1 Germline Gene Mutation in Young Uveal Melanoma Patients. Ophthalmic Genet. 2015;36:126-31 pubmed publisher
    To evaluate the prevalence of BAP1 germline mutations in a series of young patients with uveal melanoma (UM), diagnosed before age 30. The study was carried out on 14 young uveal melanoma patients (average age 21...
  61. Joseph N, Chen Y, Nasr A, Yeh I, Talevich E, Onodera C, et al. Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X. Mod Pathol. 2017;30:246-254 pubmed publisher
    ..The most frequent genetic alteration was biallelic inactivation of the BAP1 gene, which occurred in 9/13 cases, with an additional two cases demonstrating monoallelic loss of BAP1...
  62. Hanpude P, Bhattacharya S, Kumar Singh A, Kanti Maiti T. Ubiquitin recognition of BAP1: understanding its enzymatic function. Biosci Rep. 2017;37: pubmed publisher
    BRCA1-associated protein 1 (BAP1) is a nuclear localizing UCH, having tumor suppressor activity and is widely involved in many crucial cellular processes...
  63. Srivastava A, Ritesh K, Tsan Y, Liao R, Su F, Cao X, et al. De novo dominant ASXL3 mutations alter H2A deubiquitination and transcription in Bainbridge-Ropers syndrome. Hum Mol Genet. 2016;25:597-608 pubmed publisher
    ..We found that ASXL3 interacts with BAP1, a hydrolase that removes mono-ubiquitin from histone H2A lysine 119 (H2AK119Ub1) as a component of the Polycomb ..
  64. Onken M, Li J, Cooper J. Uveal melanoma cells utilize a novel route for transendothelial migration. PLoS ONE. 2014;9:e115472 pubmed publisher
    ..VCAM is present on endothelial cells, and anti-VCAM antibodies slowed the process of intercalation. Depletion of BAP1, a known suppressor of metastasis in patients, increased the amount of transmigration of uveal melanoma cells in ..
  65. Ewens K, Kanetsky P, Richards Yutz J, Purrazzella J, Shields C, Ganguly T, et al. Chromosome 3 status combined with BAP1 and EIF1AX mutation profiles are associated with metastasis in uveal melanoma. Invest Ophthalmol Vis Sci. 2014;55:5160-7 pubmed publisher
    Somatic mutations in GNAQ, GNA11, SF3B1, EIF1AX, and BAP1 have been identified in uveal melanoma (UM)...
  66. Eide N, Garred Ø, Beiske K, Fodstad Ø. Bilateral uveal melanomas with different gene expression detected with 7 years interval. Acta Ophthalmol. 2016;94:99-102 pubmed publisher
    ..b>BAP1 was positive showing nuclear staining of the tumour cells...
  67. Parrotta R, Okonska A, Ronner M, Weder W, Stahel R, Penengo L, et al. A Novel BRCA1-Associated Protein-1 Isoform Affects Response of Mesothelioma Cells to Drugs Impairing BRCA1-Mediated DNA Repair. J Thorac Oncol. 2017;12:1309-1319 pubmed publisher
    BRCA1 associated protein1 (BAP1) is a tumor suppressor involved in multiple cellular processes such as transcriptional regulation, chromatin modification by deubiquitinating histone 2A, and DNA repair...
  68. Parasramka M, Yan I, Wang X, Nguyen P, Matsuda A, Maji S, et al. BAP1 dependent expression of long non-coding RNA NEAT-1 contributes to sensitivity to gemcitabine in cholangiocarcinoma. Mol Cancer. 2017;16:22 pubmed publisher
    Genetic alterations in chromatin modulators such as BRCA-1 associated protein-1 (BAP1) are the most frequent genetic alteration in intrahepatic cholangiocarcinomas (CCA)...
  69. Schunselaar L, Zwart W, Baas P. Targeting BAP1: a new paradigm for mesothelioma. Lung Cancer. 2017;109:145-146 pubmed publisher
    New treatment strategies for malignant pleural mesothelioma (MPM) are important. BAP1 mutations are present in 47-67% of the MPM tumors, making this a good target for treatment...
  70. Brugarolas J. PBRM1 and BAP1 as novel targets for renal cell carcinoma. Cancer J. 2013;19:324-32 pubmed publisher
    ..genes are mutated at low frequencies, but 3 genes are mutated in more than 10% of ccRCC, PBRM1 (mutated in ~50%), BAP1 (~15%), and SETD2 (~15%). Like VHL, all 3 genes are 2-hit tumor suppressor genes...
  71. Murali R, Wiesner T, Scolyer R. Tumours associated with BAP1 mutations. Pathology. 2013;45:116-26 pubmed publisher
    b>BAP1 (BRCA1-Associated Protein 1) was initially identified as a protein that binds to BRCA1...
  72. Pillappa R, Maleszewski J, Sukov W, Bedroske P, Greipp P, Boland J, et al. Loss of BAP1 Expression in Atypical Mesothelial Proliferations Helps to Predict Malignant Mesothelioma. Am J Surg Pathol. 2017;: pubmed publisher
    ..Recently, loss of BRCA1-associated protein 1 (BAP1) expression and/or homozygous deletion of CDKN2A were identified in some MM, but not in reactive mesothelial ..
  73. Yang M, Li D, Yang W, Zhang Y, Liu J, Tong W. A Gene Module-Based eQTL Analysis Prioritizing Disease Genes and Pathways in Kidney Cancer. Comput Struct Biotechnol J. 2017;15:463-470 pubmed publisher
    ..Our study yielded a list of candidate disease genes, including several known ccRCC causative genes such as BAP1 and PBRM1, as well as novel genes such as NOD2, RRM1, CSRNP1, SLC4A2, TTLL1 and CNTN1...
  74. Peng J, Ma J, Li W, Mo R, Zhang P, Gao K, et al. Stabilization of MCRS1 by BAP1 prevents chromosome instability in renal cell carcinoma. Cancer Lett. 2015;369:167-74 pubmed publisher
    ..BRCA1-associated protein-1 (BAP1) was identified as one of the most frequently mutated genes in ccRCC, suggesting that BAP1 is a potential key ..
  75. Daou S, Hammond Martel I, Mashtalir N, Barbour H, Gagnon J, Iannantuono N, et al. The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer. J Biol Chem. 2015;290:28643-63 pubmed publisher
    The deubiquitinase (DUB) and tumor suppressor BAP1 catalyzes ubiquitin removal from histone H2A Lys-119 and coordinates cell proliferation, but how BAP1 partners modulate its function remains poorly understood...
  76. Wang X, Wang Z, Huang J, Ren X, Ye D, Zhu W, et al. Tissue-specific significance of BAP1 gene mutation in prognostic prediction and molecular taxonomy among different types of cancer. Tumour Biol. 2017;39:1010428317699111 pubmed publisher
    b>BAP1 is an emerging tumor suppressor whose inactivating mutations have been found to play critical roles in tumor development...
  77. Yoshikawa Y, Sato A, Tsujimura T, Emi M, Morinaga T, Fukuoka K, et al. Frequent inactivation of the BAP1 gene in epithelioid-type malignant mesothelioma. Cancer Sci. 2012;103:868-74 pubmed publisher
    In the present study, we analyzed genomic alterations of BRCA1-associated protein 1 (BAP1) in 23 malignant mesotheliomas (MMs), 16 epithelioid and seven non-epithelioid, consisting of 18 clinical specimens and five established cell lines...
  78. Yavuzyigitoglu S, Koopmans A, Verdijk R, Vaarwater J, Eussen B, van Bodegom A, et al. Uveal Melanomas with SF3B1 Mutations: A Distinct Subclass Associated with Late-Onset Metastases. Ophthalmology. 2016;123:1118-28 pubmed publisher
    ..For the detection of BAP1 mutations, a previously reported cohort of 90 patients was extended using BAP1 sequencing or immunohistochemistry...
  79. Martorano L, Winkelmann R, Cebulla C, Abdel Rahman M, Campbell S. Ocular melanoma and the BAP1 hereditary cancer syndrome: implications for the dermatologist. Int J Dermatol. 2014;53:657-63 pubmed publisher
    ..Spitz tumors, and other internal malignancies due to a germline mutation of the BRCA1-associated protein 1 (BAP1) gene...
  80. Shah A, Bourne T, Murali R. BAP1 protein loss by immunohistochemistry: a potentially useful tool for prognostic prediction in patients with uveal melanoma. Pathology. 2013;45:651-6 pubmed publisher
    ..Recently, biallelic inactivation of the BAP1 gene was shown to be associated with increased risk of metastasis in patients with uveal melanoma...
  81. Abdel Wahab O, Adli M, Lafave L, Gao J, Hricik T, Shih A, et al. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell. 2012;22:180-93 pubmed publisher
    ..We demonstrate that ASXL1 associates with the PRC2, and that loss of ASXL1 in vivo collaborates with NRASG12D to promote myeloid leukemogenesis. ..
  82. Je E, Lee S, Yoo N. Somatic mutation of a tumor suppressor gene BAP1 is rare in breast, prostate, gastric and colorectal cancers. APMIS. 2012;120:855-6 pubmed publisher
  83. Wang N, Li Y, Zhou J. miR-31 Functions as an Oncomir Which Promotes Epithelial-Mesenchymal Transition via Regulating BAP1 in Cervical Cancer. Biomed Res Int. 2017;2017:6361420 pubmed publisher
    ..The aim of this study was to validate the potential role of miR-31 and BRCA1-associated protein-1 (BAP1) on regulating epithelial-mesenchymal transition (EMT) in cervical cancer...
  84. Nagarkatti Gude N, Wang Y, Ali M, Honavar S, Jager M, Chan C. Genetics of primary intraocular tumors. Ocul Immunol Inflamm. 2012;20:244-54 pubmed publisher
    ..In uveal melanoma, monosomy 3 is the most common genetic alteration and somatic mutations of BAP1, a tumor suppressor gene, have been reported in nearly 50% of primary uveal melanomas...
  85. Cheung M, Kadariya Y, Talarchek J, Pei J, Ohar J, Kayaleh O, et al. Germline BAP1 mutation in a family with high incidence of multiple primary cancers and a potential gene-environment interaction. Cancer Lett. 2015;369:261-5 pubmed publisher
    ..cutaneous melanomas, basal cell carcinomas, and meningiomas segregating with a germline nonsense mutation in BAP1 (c.1938T>A; p.Y646X)...
  86. Qin J, Zhou Z, Chen W, Wang C, Zhang H, Ge G, et al. BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5. Nat Commun. 2015;6:8471 pubmed publisher
    ..Here we show that, in breast cancer cells, KLF5 is stabilized by the deubiquitinase (DUB) BAP1. With a genome-wide siRNA library screen of DUBs, we identify BAP1 as a bona fide KLF5 DUB...
  87. Togo Y, Yoshikawa Y, Suzuki T, Nakano Y, Kanematsu A, Zozumi M, et al. Genomic profiling of the genes on chromosome 3p in sporadic clear cell renal cell carcinoma. Int J Oncol. 2016;48:1571-80 pubmed publisher
    Somatic mutations of the BRCA1 associated protein-1 (BAP1) gene, which maps to 3p21, have been found in several tumors including malignant mesothelioma, uveal melanoma, and renal cell carcinoma (RCC)...
  88. Johnson C, Kim I, Esmaeli B, Amin Mansour A, Treacy D, Carter S, et al. Systematic genomic and translational efficiency studies of uveal melanoma. PLoS ONE. 2017;12:e0178189 pubmed publisher
    ..Known recurrent mutations were identified in GNAQ, GNA11, BAP1, EIF1AX, and SF3B1...
  89. Wei X, Choudhury Y, Lim W, Anema J, Kahnoski R, Lane B, et al. Recognizing the Continuous Nature of Expression Heterogeneity and Clinical Outcomes in Clear Cell Renal Cell Carcinoma. Sci Rep. 2017;7:7342 pubmed publisher
    ..Multiple somatic mutations (VHL, PBRM1, SETD2, KDM5C, TP53, BAP1, PTEN, MTOR) were associated with the CLEAR score...
  90. Yu H, Pak H, Hammond Martel I, Ghram M, Rodrigue A, Daou S, et al. Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair. Proc Natl Acad Sci U S A. 2014;111:285-90 pubmed publisher
    ..Here, we conducted a functional RNAi screen and identified BAP1 as a deubiquitinase required for efficient assembly of the homologous recombination (HR) factors BRCA1 and RAD51 at ..
  91. Popova T, Hebert L, Jacquemin V, Gad S, Caux Moncoutier V, Dubois d Enghien C, et al. Germline BAP1 mutations predispose to renal cell carcinomas. Am J Hum Genet. 2013;92:974-80 pubmed publisher
    ..By combining whole-exome sequencing and tumor profiling in a family prone to cases of RCC, we identified a germline BAP1 mutation c.277A>G (p.Thr93Ala) as the probable genetic basis of RCC predisposition...
  92. Gossage L, Murtaza M, Slatter A, Lichtenstein C, Warren A, Haynes B, et al. Clinical and pathological impact of VHL, PBRM1, BAP1, SETD2, KDM6A, and JARID1c in clear cell renal cell carcinoma. Genes Chromosomes Cancer. 2014;53:38-51 pubmed publisher
    ..Recent studies have identified recurrent mutations in histone modifying and chromatin remodeling genes, including BAP1, PBRM1, SETD2, KDM6A, and JARID1c...