BANF1

Summary

Gene Symbol: BANF1
Description: barrier to autointegration factor 1
Alias: BAF, BCRP1, D14S1460, NGPS, barrier-to-autointegration factor, breakpoint cluster region protein 1
Species: human
Products:     BANF1

Top Publications

  1. Shimi T, Koujin T, Segura Totten M, Wilson K, Haraguchi T, Hiraoka Y. Dynamic interaction between BAF and emerin revealed by FRAP, FLIP, and FRET analyses in living HeLa cells. J Struct Biol. 2004;147:31-41 pubmed
    Barrier-to-autointegration factor (BAF) is a conserved 10 kDa DNA-binding protein. BAF interacts with LEM-domain proteins including emerin, LAP2 beta, and MAN1 in the inner nuclear membrane...
  2. Puente X, Quesada V, Osorio F, Cabanillas R, Cadinanos J, Fraile J, et al. Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome. Am J Hum Genet. 2011;88:650-6 pubmed publisher
    ..Exome sequencing and molecular analysis in two unrelated families allowed us to identify a homozygous mutation in BANF1 (c.34G>A [p...
  3. Haraguchi T, Koujin T, Segura Totten M, Lee K, Matsuoka Y, Yoneda Y, et al. BAF is required for emerin assembly into the reforming nuclear envelope. J Cell Sci. 2001;114:4575-85 pubmed
    ..Barrier-to-autointegration factor (BAF), a protein that binds nonspecifically to double-stranded DNA in vitro, co-localized with emerin at the 'core' ..
  4. Asencio C, Davidson I, Santarella Mellwig R, Ly Hartig T, Mall M, Wallenfang M, et al. Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis. Cell. 2012;150:122-35 pubmed publisher
    ..NE disassembly is driven by multiple phosphorylation events. Mitotic phosphorylation of the protein BAF reduces its affinity for chromatin and the LEM family of inner nuclear membrane proteins; loss of this BAF-mediated ..
  5. Harris D, Engelman A. Both the structure and DNA binding function of the barrier-to-autointegration factor contribute to reconstitution of HIV type 1 integration in vitro. J Biol Chem. 2000;275:39671-7 pubmed
    ..Barrier-to-autointegration factor (BAF) is a host protein that efficiently restores PIC activity, but the mechanism(s) by which BAF participates in HIV-1 ..
  6. Lee K, Haraguchi T, Lee R, Koujin T, Hiraoka Y, Wilson K. Distinct functional domains in emerin bind lamin A and DNA-bridging protein BAF. J Cell Sci. 2001;114:4567-73 pubmed
    ..We show that emerin binds directly to barrier-to-autointegration factor (BAF), a DNA-bridging protein, and that this binding to BAF requires conserved residues in the LEM-motif of emerin...
  7. Mansharamani M, Graham D, Monie D, Lee K, Hildreth J, Siliciano R, et al. Barrier-to-autointegration factor BAF binds p55 Gag and matrix and is a host component of human immunodeficiency virus type 1 virions. J Virol. 2003;77:13084-92 pubmed
    Barrier-to-autointegration factor (BAF) is a conserved human chromatin protein exploited by retroviruses...
  8. Cox J, Mallanna S, Ormsbee B, Desler M, Wiebe M, Rizzino A. Banf1 is required to maintain the self-renewal of both mouse and human embryonic stem cells. J Cell Sci. 2011;124:2654-65 pubmed publisher
    ..Through an unbiased proteomic screen, Banf1 was identified as a Sox2-associated protein...
  9. Wang X, Xu S, Rivolta C, Li L, Peng G, Swain P, et al. Barrier to autointegration factor interacts with the cone-rod homeobox and represses its transactivation function. J Biol Chem. 2002;277:43288-300 pubmed
    ..One of the identified clones encodes Baf (barrier to autointegration factor), which was previously shown to have a role in mitosis and retroviral integration...

More Information

Publications89

  1. Capanni C, Cenni V, Haraguchi T, Squarzoni S, Schüchner S, Ogris E, et al. Lamin A precursor induces barrier-to-autointegration factor nuclear localization. Cell Cycle. 2010;9:2600-10 pubmed publisher
    ..may be involved in prelamin A chromatin remodeling effects, we investigated barrier-to-autointegration factor (BAF) localization and expression in prelamin A accumulating cells...
  2. Bengtsson L, Wilson K. Barrier-to-autointegration factor phosphorylation on Ser-4 regulates emerin binding to lamin A in vitro and emerin localization in vivo. Mol Biol Cell. 2006;17:1154-63 pubmed
    Barrier-to-autointegration factor (BAF) is a conserved 10-kDa chromatin protein essential in proliferating cells. BAF dimers bind double-stranded DNA, histone H3, histone H1...
  3. Haraguchi T, Kojidani T, Koujin T, Shimi T, Osakada H, Mori C, et al. Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly. J Cell Sci. 2008;121:2540-54 pubmed publisher
    ..Time-lapse, FRAP and FRET analyses in human cells showed that barrier-to-autointegration factor (BAF), a DNA-binding protein, assembled first at the distinct ;core' region of the telophase chromosome and formed an ..
  4. Haraguchi T, Koujin T, Osakada H, Kojidani T, Mori C, Masuda H, et al. Nuclear localization of barrier-to-autointegration factor is correlated with progression of S phase in human cells. J Cell Sci. 2007;120:1967-77 pubmed
    Barrier-to-autointegration factor (BAF) is a conserved metazoan protein that plays a critical role in retrovirus infection...
  5. Bradley C, Ronning D, Ghirlando R, Craigie R, Dyda F. Structural basis for DNA bridging by barrier-to-autointegration factor. Nat Struct Mol Biol. 2005;12:935-6 pubmed
    The ability of barrier-to-autointegration factor (BAF) to bind and bridge DNA in a sequence-independent manner is crucial for its role in retroviral integration and a variety of cellular processes...
  6. Cabanillas R, Cadinanos J, Villameytide J, Perez M, Longo J, Richard J, et al. Néstor-Guillermo progeria syndrome: a novel premature aging condition with early onset and chronic development caused by BANF1 mutations. Am J Med Genet A. 2011;155A:2617-25 pubmed publisher
    Progeria syndromes are rare disorders that involve premature aging. Mutations in BANF1 have been recently reported to cause a new hereditary progeroid syndrome that we now propose to call the Néstor-Guillermo progeria syndrome (NGPS)...
  7. Umland T, Wei S, Craigie R, Davies D. Structural basis of DNA bridging by barrier-to-autointegration factor. Biochemistry. 2000;39:9130-8 pubmed
    Barrier-to-autointegration factor (BAF) is a host cell protein that plays a crucial role in retroviral integration...
  8. Hirano Y, Segawa M, Ouchi F, Yamakawa Y, Furukawa K, Takeyasu K, et al. Dissociation of emerin from barrier-to-autointegration factor is regulated through mitotic phosphorylation of emerin in a xenopus egg cell-free system. J Biol Chem. 2005;280:39925-33 pubmed
    ..of the former, and this plays a critical role in the dissociation of emerin from barrier-to-autointegration factor (BAF). Then, we analyzed the mitotic phosphorylation sites of emerin...
  9. Wiebe M, Traktman P. Poxviral B1 kinase overcomes barrier to autointegration factor, a host defense against virus replication. Cell Host Microbe. 2007;1:187-97 pubmed publisher
    b>Barrier to autointegration factor (BAF) is a DNA-binding protein found in the nucleus and cytoplasm of eukaryotic cells that functions to establish nuclear architecture during mitosis...
  10. Montes De Oca R, Andreassen P, Wilson K. Barrier-to-Autointegration Factor influences specific histone modifications. Nucleus. 2011;2:580-90 pubmed publisher
    ..Barrier-to-Autointegration Factor (BAF) is an essential but enigmatic lamina component that binds lamins, LEM-domain proteins, DNA and histone H3 directly...
  11. Kim W, Chakraborty G, Kim S, Shin J, Park C, Jeong M, et al. Macro histone H2A1.2 (macroH2A1) protein suppresses mitotic kinase VRK1 during interphase. J Biol Chem. 2012;287:5278-89 pubmed publisher
    ..2 by NMR spectroscopy. Hence, our findings might provide valuable insight into the underlying molecular mechanism regarding an epigenetic regulation of histone H3 during the cell cycle. ..
  12. Lee M, Craigie R. A previously unidentified host protein protects retroviral DNA from autointegration. Proc Natl Acad Sci U S A. 1998;95:1528-33 pubmed
    ..The identity of the protein was confirmed by expressing it in Escherichia coli and demonstrating the activity of the heterologously expressed protein in the reconstitution assay. ..
  13. Cai M, Huang Y, Zheng R, Wei S, Ghirlando R, Lee M, et al. Solution structure of the cellular factor BAF responsible for protecting retroviral DNA from autointegration. Nat Struct Biol. 1998;5:903-9 pubmed
    The solution structure of the human barrier-to-autointegration factor, BAF, a 21,000 Mr dimer, has been solved by NMR, including extensive use of dipolar couplings which provide a priori long range structural information...
  14. Lin C, Engelman A. The barrier-to-autointegration factor is a component of functional human immunodeficiency virus type 1 preintegration complexes. J Virol. 2003;77:5030-6 pubmed
    ..two different cell proteins, high-mobility group protein A1 (HMGA1) and the barrier-to-autointegration factor (BAF), were identified as integration cofactors based on activities in in vitro PIC assays, only HMGA1 was previously ..
  15. Brachner A, Braun J, Ghodgaonkar M, Castor D, Zlopasa L, Ehrlich V, et al. The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo. J Cell Sci. 2012;125:1048-57 pubmed publisher
    ..interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF)...
  16. Holaska J, Lee K, Kowalski A, Wilson K. Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro. J Biol Chem. 2003;278:6969-75 pubmed
    ..The LEM domain mediates direct binding to barrier to autointegration factor (BAF), a conserved 10-kDa chromatin protein essential for embryogenesis in Caenorhabditis elegans...
  17. Zheng R, Ghirlando R, Lee M, Mizuuchi K, Krause M, Craigie R. Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex. Proc Natl Acad Sci U S A. 2000;97:8997-9002 pubmed
    Barrier-to-autointegration factor (BAF) is a highly conserved cellular protein that was identified by its activity in protecting retroviral DNA against autointegration...
  18. Mansharamani M, Wilson K. Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor. J Biol Chem. 2005;280:13863-70 pubmed
    ..studies showed that MAN1-C binds the transcription regulators GCL, Btf, and barrier-to-autointegration factor (BAF). BAF binding to this region, which has no LEM domain, was notable...
  19. Segura Totten M, Kowalski A, Craigie R, Wilson K. Barrier-to-autointegration factor: major roles in chromatin decondensation and nuclear assembly. J Cell Biol. 2002;158:475-85 pubmed
    Barrier-to-autointegration factor (BAF) is a DNA-bridging protein, highly conserved in metazoans. BAF binds directly to LEM (LAP2, emerin, MAN1) domain nuclear membrane proteins, including LAP2 and emerin...
  20. Furukawa K. LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of LAP2-chromatin interaction. J Cell Sci. 1999;112 ( Pt 15):2485-92 pubmed
    ..sequence is predicted to encode a protein of 89 amino acids which turns out to be a rat homolog of mouse and human BAF (Barrier-to-Autointegration Factor). L2BP1 is distributed diffusely throughout the nucleus in interphase cells...
  21. Berk J, Maitra S, Dawdy A, Shabanowitz J, Hunt D, Wilson K. O-Linked ?-N-acetylglucosamine (O-GlcNAc) regulates emerin binding to barrier to autointegration factor (BAF) in a chromatin- and lamin B-enriched "niche". J Biol Chem. 2013;288:30192-209 pubmed publisher
    Emerin, a membrane component of nuclear "lamina" networks with lamins and barrier to autointegration factor (BAF), is highly O-GlcNAc-modified ("O-GlcNAcylated") in mammalian cells...
  22. Montes De Oca R, Lee K, Wilson K. Binding of barrier to autointegration factor (BAF) to histone H3 and selected linker histones including H1.1. J Biol Chem. 2005;280:42252-62 pubmed
    b>Barrier to autointegration factor (BAF) is an essential conserved double-stranded DNA-binding protein in metazoans. BAF binds directly to LEM domain nuclear proteins (e.g...
  23. Dechat T, Gajewski A, Korbei B, Gerlich D, Daigle N, Haraguchi T, et al. LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly. J Cell Sci. 2004;117:6117-28 pubmed
    ..Furthermore, the DNA-crosslinking protein barrier-to-autointegration factor (BAF) bound to LAP2alpha in vitro and in mitotic extracts, and subfractions of BAF relocalized to core structures with ..
  24. Qi R, Xu N, Wang G, Ren H, Li S, Lei J, et al. The lamin-A/C-LAP2α-BAF1 protein complex regulates mitotic spindle assembly and positioning. J Cell Sci. 2015;128:2830-41 pubmed publisher
    ..Here, we report that a fraction of the nuclear periphery proteins lamin-A/C, LAP2α and BAF1 (also known as BANF1) relocate to the spindle and the cell cortex in mitosis...
  25. Jonker J, Buitelaar M, Wagenaar E, van der Valk M, Scheffer G, Scheper R, et al. The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria. Proc Natl Acad Sci U S A. 2002;99:15649-54 pubmed
    ..Pheophorbide a occurs in various plant-derived foods and food supplements. Bcrp1 transports pheophorbide a and is highly efficient in limiting its uptake from ingested food...
  26. Zhang Y, Wu J, Weng L, Li X, Yu L, Xu Y. Valproic acid protects against MPP+-mediated neurotoxicity in SH-SY5Y Cells through autophagy. Neurosci Lett. 2017;638:60-68 pubmed publisher
    ..However, 3-Methyladenine (3-MA) or bafilomycin A1 (Baf-A1), blockers for autophagy, partially weakened the neuroprotective effect of VPA...
  27. An Y, Ongkeko W. ABCG2: the key to chemoresistance in cancer stem cells?. Expert Opin Drug Metab Toxicol. 2009;5:1529-42 pubmed publisher
    ..The membrane transporter protein ABCG2/BCRP1 has been shown in vitro to effectively reduce the intracellular concentrations of several prominent anticancer ..
  28. Dubey L, Karempudi P, Luther S, Ludewig B, Harris N. Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis. Nat Commun. 2017;8:367 pubmed publisher
    ..LT?R ligation on fibroblastic reticular cells leads to the production of B-cell-activating factor (BAF?F), which synergized with interleukin-4 (IL-4) to promote the production of the lymphangiogenic factors, vascular ..
  29. Liu H, Zhu L, Tian X, Yin Y. Seasonal variation of bacterial community in biological aerated filter for ammonia removal in drinking water treatment. Water Res. 2017;123:668-677 pubmed publisher
    Biological aerated filter (BAF) is widely used in wastewater treatment plants (WWTPs) and shows potential application of micropolluted drinking water sources with a higher NH4+-N removal efficiency during short warm ..
  30. Pfau M, Goerdt L, Schmitz Valckenberg S, Mauschitz M, Mishra D, Holz F, et al. Green-Light Autofluorescence Versus Combined Blue-Light Autofluorescence and Near-Infrared Reflectance Imaging in Geographic Atrophy Secondary to Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2017;58:BIO121-BIO130 pubmed publisher
    ..green-light fundus autofluorescence (GAF; excitation = 518 nm) versus combined blue-light fundus autofluorescence (BAF; excitation = 488 nm) and near-infrared reflectance (NIR; 820 nm) -based grading...
  31. Kang J, Ma T, Zhang P, Gao X, Chen Y. Characterization of soluble microbial products in a drinking water biological aerated filter. Environ Sci Pollut Res Int. 2016;23:8721-30 pubmed publisher
    ..study to characterize soluble microbial products (SMPs) in a drinking water lab-scale biological aerated filter (BAF), and their basic characteristics were explored using gel filtration chromatography and three-dimensional ..
  32. Pramanik B, Pramanik S, Suja F. Removal of arsenic and iron removal from drinking water using coagulation and biological treatment. J Water Health. 2016;14:90-6 pubmed publisher
    Effects of biological activated carbon (BAC), biological aerated filter (BAF), alum coagulation and Moringa oleifera coagulation were investigated to remove iron and arsenic contaminants from drinking water...
  33. Abdouh M, Hanna R, El Hajjar J, Flamier A, Bernier G. The Polycomb Repressive Complex 1 Protein BMI1 Is Required for Constitutive Heterochromatin Formation and Silencing in Mammalian Somatic Cells. J Biol Chem. 2016;291:182-97 pubmed publisher
    ..These observations suggest a dynamic and developmentally regulated model of PRC1 occupancy at constitutive heterochromatin, and where BMI1 function in somatic cells is to stabilize the repetitive genome. ..
  34. Cui H, Schlesinger J, Schoenhals S, Tönjes M, Dunkel I, Meierhofer D, et al. Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA. Nucleic Acids Res. 2016;44:2538-53 pubmed publisher
    DPF3 (BAF45c) is a member of the BAF chromatin remodeling complex. Two isoforms have been described, namely DPF3a and DPF3b. The latter binds to acetylated and methylated lysine residues of histones...
  35. Izhar L, Adamson B, Ciccia A, Lewis J, Pontano Vaites L, Leng Y, et al. A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors. Cell Rep. 2015;11:1486-500 pubmed publisher
    ..These include the BAF tumor suppressor complex and the amyotrophic lateral sclerosis (ALS) candidate protein TAF15...
  36. Bosch P, Fuller L, Sleeth C, Weiner J. Akirin2 is essential for the formation of the cerebral cortex. Neural Dev. 2016;11:21 pubmed
    ..indicates that Akirin2 acts as a bridge between transcription factors (including Twist and NF-?B proteins) and the BAF (SWI/SNF) chromatin remodeling machinery to regulate patterns of gene expression...
  37. Olson A, Rico A, Wang Z, Delhon G, Wiebe M. Deletion of the Vaccinia Virus B1 Kinase Reveals Essential Functions of This Enzyme Complemented Partly by the Homologous Cellular Kinase VRK2. J Virol. 2017;91: pubmed publisher
    ..Indeed, B1 and VRKs have been demonstrated to target a shared substrate, the DNA binding protein BAF, elucidating a signaling pathway important for both mitosis and the antiviral response...
  38. Parisi M, Cammarata I, Cammarata M, Censi V. Rare earths, zirconium and hafnium distribution in coastal areas: The example of Sabella spallanzanii (Gmelin, 1791). Chemosphere. 2017;185:268-276 pubmed publisher
    ..Features of the REE bioaccumulation factors (BAF), in addition to the absolute La, Ce and Sm contents and Zr-Hf fractionation, allow definition of the different ..
  39. Bindels L, Porporato P, Ducastel S, Sboarina M, Neyrinck A, Dewulf E, et al. Ffar2 expression regulates leukaemic cell growth in vivo. Br J Cancer. 2017;117:1336-1340 pubmed publisher
    ..Bcr-Abl-expressing BaF cells were used as a leukaemia model and the role of Ffar2 was evaluated in Balb/c mice after lentiviral shRNA ..
  40. Rezaitabar S, Esmaili Sari A, Bahramifar N, Ramezanpour Z. Transfer, tissue distribution and bioaccumulation of microcystin LR in the phytoplanktivorous and carnivorous fish in Anzali wetland, with potential health risks to humans. Sci Total Environ. 2017;575:1130-1138 pubmed publisher
    ..The results showed that the BAF of MC-LR in silver carp (1047±185L/kg of lipid) was lower than the northern pike (1272±185L/kg of lipid), ..
  41. Chen J, Liu Y, Zhang J, Yang Y, Hu L, Yang Y, et al. Removal of antibiotics from piggery wastewater by biological aerated filter system: Treatment efficiency and biodegradation kinetics. Bioresour Technol. 2017;238:70-77 pubmed publisher
    ..the removal efficiency and mechanism for antibiotics in swine wastewater by a biological aerated filter system (BAF system) in combination with laboratory aerobic and anaerobic incubation experiments...
  42. Zhao X, Zhang Z, Xu L, Liu L, Song W, Zhu F, et al. Occurrence and fate of benzotriazoles UV filters in a typical residential wastewater treatment plant in Harbin, China. Environ Pollut. 2017;227:215-222 pubmed publisher
    ..sludge from the WWTP with anaerobic-oxic treatment process (A/O) and biological aerated filter treatment process (BAF). Totally, 81 wastewater samples and 11 sludge samples were collected in four seasons...
  43. Chang G, Yang R, Cao Y, Nie A, Gu X, Zhang H. SIDT2 is involved in the NAADP-mediated release of calcium from insulin secretory granules. J Mol Endocrinol. 2016;56:249-59 pubmed publisher
    ..Extraordinarily, pretreatment with bafilomycin A1(Baf-A1) led to a comparable [Ca(2+)]i increase pattern between these two groups, suggesting that calcium traffic from ..
  44. Mendis M, Simsek S. Production of structurally diverse wheat arabinoxylan hydrolyzates using combinations of xylanase and arabinofuranosidase. Carbohydr Polym. 2015;132:452-9 pubmed publisher
    ..japonicas xylanase (CJX), Aspergillus niger xylanase (ANX), Bifidobacterium adolescentis arabinofuranosidase (BAF) and Clostridium thermocellum arabinofuranosidase (CAF)...
  45. Bae S, D Cunha R, Shao J, An G. Effect of 5,7-dimethoxyflavone on Bcrp1-mediated transport of sorafenib in vitro and in vivo in mice. Eur J Pharm Sci. 2018;117:27-34 pubmed publisher
    ..5,7-DMF significantly inhibited Bcrp1-mediated sorafenib efflux in a concentration dependent manner in MDCK/Bcrp1 cells, with EC50 value of 8...
  46. Dong M, Miao K, Hu Y, Wu J, Li J, Pang P, et al. Cooperating dipole-dipole and van der Waals interactions driven 2D self-assembly of fluorenone derivatives: ester chain length effect. Phys Chem Chem Phys. 2017;19:31113-31120 pubmed publisher
    ..supramolecular assemblies of a series of 2,7-bis(10-n-alkoxycarbonyl-decyloxy)-9-fluorenone derivatives (BAF-Cn, n = 1, 3-6) consisting of polar fluorenone moieties and ester alkoxy chains were investigated by scanning ..
  47. Arnaud O, Le Loarer F, Tirode F. BAFfling pathologies: Alterations of BAF complexes in cancer. Cancer Lett. 2018;419:266-279 pubmed publisher
    ..these complexes, the SWItch/Sucrose Non-Fermenting (SWI/SNF) complex, also referred to as BRG1-Associated Factor (BAF) complex, moves the nucleosome along chromatin using energy provided by ATP hydrolysis...
  48. Barton L, Lovander K, Pinto B, Geyer P. Drosophila male and female germline stem cell niches require the nuclear lamina protein Otefin. Dev Biol. 2016;415:75-86 pubmed publisher
    ..family, proteins that share an association with the chromatin binding protein Barrier-to-autointegration factor (BAF). Loss of individual LEM-D proteins causes progressive, tissue-restricted diseases, known as laminopathies...
  49. Franco F, Jojima C, Perez M, Zappi D, Taylor N, Moraes E. The xeric side of the Brazilian Atlantic Forest: The forces shaping phylogeographic structure of cacti. Ecol Evol. 2017;7:9281-9293 pubmed publisher
    In order to investigate biogeographic influences on xeric biota in the Brazilian Atlantic Forest (BAF), a biodiversity hotspot, we used a monophyletic group including three cactus taxa as a model to perform a phylogeographic study: ..
  50. Ritter B, Haida P, Fink F, Krahl T, Gawlitza K, Rurack K, et al. Novel and easy access to highly luminescent Eu and Tb doped ultra-small CaF2, SrF2 and BaF2 nanoparticles - structure and luminescence. Dalton Trans. 2017;46:2925-2936 pubmed publisher
    ..to transparent sols of nanoscopic Eu3+ and Tb3+ doped CaF2, SrF2 and BaF2 particles via the fluorolytic sol-gel synthesis route is presented...
  51. Durmus S, Xu N, Sparidans R, Wagenaar E, Beijnen J, Schinkel A. P-glycoprotein (MDR1/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) restrict brain accumulation of the JAK1/2 inhibitor, CYT387. Pharmacol Res. 2013;76:9-16 pubmed publisher
    ..In vitro, CYT387 was efficiently transported by both human MDR1 and BCRP, and very efficiently by mouse Bcrp1 and its transport could be inhibited by specific MDR1 inhibitor, zosuquidar and/or specific BCRP inhibitor, Ko143...
  52. Real R, Egido E, Perez M, Gonzalez Lobato L, Barrera B, Prieto J, et al. Involvement of breast cancer resistance protein (BCRP/ABCG2) in the secretion of danofloxacin into milk: interaction with ivermectin. J Vet Pharmacol Ther. 2011;34:313-21 pubmed publisher
    ..The main purpose was to determine whether danofloxacin is an in vitro substrate for Bcrp1/BCRP and to assess its involvement in danofloxacin secretion into milk...
  53. Xie Y, Natarajan K, Bauer K, Nakanishi T, Beck W, Moreci R, et al. Bcrp1 transcription in mouse testis is controlled by a promoter upstream of a novel first exon (E1U) regulated by steroidogenic factor-1. Biochim Biophys Acta. 2013;1829:1288-99 pubmed publisher
    ..The murine Bcrp1 (Abcg2) transporter has three alternative promoters associated with mRNAs containing alternative untranslated ..
  54. Chen Z, Li M, Wen Q. Comprehensive evaluation of three sets of advanced wastewater treatment trains for treating secondary effluent: Organic micro-pollutants and bio-toxicity. Chemosphere. 2017;189:426-434 pubmed publisher
    ..commonly used advanced wastewater treatment trains, coagulation-sand filter, coagulation-biological aerated filter (BAF) and ozonation-biological activated carbon (BAC), in removing fifteen residual contaminants and bio-toxicity of the ..
  55. Polli J, Olson K, Chism J, John Williams L, Yeager R, Woodard S, et al. An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino. Drug Metab Dispos. 2009;37:439-42 pubmed publisher
    ..Pgp; the protein from the Mdr1a/b gene) and breast cancer resistance protein (Bcrp; the protein from the Bcrp1 gene) in modulating the central nervous system penetration of lapatinib at steady-state conditions in FVBn mice (..
  56. He Q, Sha S, Sun L, Zhang J, Dong M. GLP-1 analogue improves hepatic lipid accumulation by inducing autophagy via AMPK/mTOR pathway. Biochem Biophys Res Commun. 2016;476:196-203 pubmed publisher
    ..LRG and two inhibitors of autophagy, Chloroquine (CQ) and bafilomycin A1 (Baf), were added into each group, respectively...
  57. Jonker J, Smit J, Brinkhuis R, Maliepaard M, Beijnen J, Schellens J, et al. Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan. J Natl Cancer Inst. 2000;92:1651-6 pubmed
    ..We also used the BCRP inhibitor GF120918 to assess the role of BCRP in protecting mice against xenobiotic drugs. Bcrp1, the murine homologue of BCRP, was expressed in the polarized mammalian cell lines LLC-PK1 and MDCK-II, and the ..
  58. Jones S, Fleuren E, Frankum J, Konde A, Williamson C, Krastev D, et al. ATR Is a Therapeutic Target in Synovial Sarcoma. Cancer Res. 2017;77:7014-7026 pubmed publisher
    ..Oncogenic SS18-SSX family fusion genes are known to alter the composition of the BAF chromatin-remodeling complex, causing ejection and degradation of wild-type SS18 and the tumor suppressor SMARCB1...
  59. Krauze A, Grinberga S, Krasnova L, Adlere I, Sokolova E, Domracheva I, et al. Thieno[2,3-b]pyridines--a new class of multidrug resistance (MDR) modulators. Bioorg Med Chem. 2014;22:5860-70 pubmed publisher
    ..All synthesized compounds were tested to determine BCRP1, P-gp, and MRP1 inhibitor activity, and most potent MDR modulators were also screened for their toxicity, ..
  60. Sun X, Hota S, Zhou Y, NOVAK S, Miguel Perez D, Christodoulou D, et al. Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function. Biol Open. 2018;7: pubmed publisher
    ..For example, Baf60c (Smarcd3) encodes a cardiac-enriched subunit of the SWI/SNF-like BAF chromatin complex, but its role in heart development is not fully understood...
  61. An G, Gallegos J, Morris M. The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux. Drug Metab Dispos. 2011;39:426-32 pubmed publisher
    ..6-fold (from 97.5 to 8.37) in the presence of kaempferol in MDCK/Bcrp1 cells, indicating that kaempferol is a Bcrp inhibitor...
  62. Sun M, Heald R. A DNA Crosslinker Collects Mitotic Chromosomes. Dev Cell. 2017;42:440-442 pubmed publisher
    ..In a recent Cell paper, Samwer et al. (2017) show that by non-covalently crosslinking DNA, BAF promotes chromosome coalescence, preventing nuclear membranes from enwrapping individual chromosomes to form ..
  63. Sakai K, Ukita M, Schmidt J, Wu L, De Velasco M, Roter A, et al. Clonal composition of human ovarian cancer based on copy number analysis reveals a reciprocal relation with oncogenic mutation status. Cancer Lett. 2017;405:22-28 pubmed publisher
    ..Genome-wide segmentation data consisting of the log2 ratio (log2R) and B allele frequency (BAF) were used to calculate an estimate of the clonal composition number (CC number) for each tumor...
  64. Mogi M, Yang J, Lambert J, Colvin G, Shiojima I, Skurk C, et al. Akt signaling regulates side population cell phenotype via Bcrp1 translocation. J Biol Chem. 2003;278:39068-75 pubmed
    ..b>Bcrp1, which encodes the Hoechst dye transporter, was translocated from the membrane to the intracellular compartment ..
  65. Summer R, Kotton D, Sun X, Ma B, Fitzsimmons K, Fine A. Side population cells and Bcrp1 expression in lung. Am J Physiol Lung Cell Mol Physiol. 2003;285:L97-104 pubmed
    ..Surface marker analysis revealed lung SP cells to be stem cell antigen 1 positive, Bcrp1 positive, lineage marker negative, and heterogeneous at the CD45 locus...
  66. Cai J, Weiner J, Wang R, Luo W, Zhang Y, Liu H, et al. Effects of nitrogen and water addition on trace element stoichiometry in five grassland species. J Plant Res. 2017;130:659-668 pubmed publisher
    ..In addition, bioaccumulation factors (BAF, the ratio of the chemical concentration in the organism and the chemical concentration in the growth substrate) ..
  67. Anning A, Akoto R. Assisted phytoremediation of heavy metal contaminated soil from a mined site with Typha latifolia and Chrysopogon zizanioides. Ecotoxicol Environ Saf. 2018;148:97-104 pubmed publisher
    ..Here, bioaccumulation factor (BAF), translocation factor (TF), removal efficiency (RE) and uptake of Hg, As, Pb, Cu and Zn by cattail (Typha ..
  68. Li J, Wang T, Pei L, Jing J, Hu W, Sun T, et al. Expression of VRK1 and the downstream gene BANF1 in esophageal cancer. Biomed Pharmacother. 2017;89:1086-1091 pubmed publisher
    ..In this study, we examined the expression of vaccinia-related kinase 1 (VRK1) and barrier to autointegration factor 1 (BANF1) in tumor tissues at the mRNA and protein levels via real-time PCR and immunohistochemical ..
  69. Aihemaiti A, Jiang J, Li D, Li T, Zhang W, Ding X. Toxic metal tolerance in native plant species grown in a vanadium mining area. Environ Sci Pollut Res Int. 2017;24:26839-26850 pubmed publisher
    ..plants, V, chromium, copper and zinc concentrations in roots and shoots were measured and the bioaccumulation (BAF) and translocation (TF) efficiencies were calculated...
  70. Alfaras I, Perez M, Juan M, Merino G, Prieto J, Planas J, et al. Involvement of breast cancer resistance protein (BCRP1/ABCG2) in the bioavailability and tissue distribution of trans-resveratrol in knockout mice. J Agric Food Chem. 2010;58:4523-8 pubmed publisher
    ..and tissue distribution of trans-resveratrol and its metabolites after the oral administration of 60 mg/kg in Bcrp1(-/-) mice. trans-Resveratrol and its metabolites were measured in intestinal content, plasma and tissues by HPLC...
  71. Chen A, Lan Y, Liu J, Zhang F, Zhang L, Li B, et al. The structure property and endothelial protective activity of fucoidan from Laminaria japonica. Int J Biol Macromol. 2017;105:1421-1429 pubmed publisher
    ..However, the highly sulfated fucoidan fractions F2 and LF2 were better at inducing FGFR1c-expressing BaF3 cell proliferation in the presence of FGF-1, -2, -7, -8, -9 or -10...
  72. Alvarez A, Vallejo F, Barrera B, Merino G, Prieto J, Tomás Barberán F, et al. Bioavailability of the glucuronide and sulfate conjugates of genistein and daidzein in breast cancer resistance protein 1 knockout mice. Drug Metab Dispos. 2011;39:2008-12 pubmed publisher
    ..metabolites, glucuronides, and sulfates, after intragastric administration of these isoflavones to wild-type and Bcrp1(-/-) knockout mice...
  73. Mukhopadhyay S, Rana V, Kumar A, Maiti S. Biodiversity variability and metal accumulation strategies in plants spontaneously inhibiting fly ash lagoon, India. Environ Sci Pollut Res Int. 2017;24:22990-23005 pubmed publisher
    ..The biological indices (BCF, BAF, and TF) revealed that E. prostrata (10 mg Cd kg-1) and C. procera (3...
  74. Otto J, Kadoch C. A Two-Faced mSWI/SNF Subunit: Dual Roles for ARID1A in Tumor Suppression and Oncogenicity in the Liver. Cancer Cell. 2017;32:542-543 pubmed publisher
    In this issue of Cancer Cell, Sun et al. describe context-dependent oncogenic and tumor-suppressive functions for the mammalian SWI/SNF (BAF) complex subunit ARID1A in the development and progression of hepatocellular carcinoma (HCC).
  75. Jang S, Kim C, Kim J, Choi K. Transcriptional regulatory network of SOX4 during myoblast differentiation. Biochem Biophys Res Commun. 2015;462:365-70 pubmed publisher
    ..Lamin B2, barrier to autointegration factor 1, and apolipoprotein C-III were identified as novel interacting partners of SOX4 by yeast two-..
  76. Hu B, Jia X, Hu J, Xu D, Xia F, Li Y. Assessment of Heavy Metal Pollution and Health Risks in the Soil-Plant-Human System in the Yangtze River Delta, China. Int J Environ Res Public Health. 2017;14: pubmed publisher
    ..The bioaccumulation factor (BAF) was used to investigate the translocation of heavy metals in the soil-crop system...
  77. Li X, Wang C, Zhao J, Liu L. A New Method for Determining the Optical Constants of Highly Transparent Solids. Appl Spectrosc. 2017;71:70-77 pubmed publisher
    ..The optical constants of three highly transparent substrates (polycrystalline BaF2, CaF2, and MgF2) were experimentally determined within wavelength range from ..
  78. Loi M, Cenni V, Duchi S, Squarzoni S, Lopez Otin C, Foisner R, et al. Barrier-to-autointegration factor (BAF) involvement in prelamin A-related chromatin organization changes. Oncotarget. 2016;7:15662-77 pubmed publisher
    ..In this study we demonstrate that BAF is necessary to modulate prelamin A effects on chromatin structure...
  79. Lassalle B, Bastos H, Louis J, Riou L, Testart J, Dutrillaux B, et al. 'Side Population' cells in adult mouse testis express Bcrp1 gene and are enriched in spermatogonia and germinal stem cells. Development. 2004;131:479-87 pubmed
    ..We show that mouse testicular cells also display a 'Side Population' that express Bcrp1 mRNA, the ABC transporter responsible for Hoechst efflux in hematopoietic cells...
  80. Kalabis G, Petropoulos S, Gibb W, Matthews S. Breast cancer resistance protein (Bcrp1/Abcg2) in mouse placenta and yolk sac: ontogeny and its regulation by progesterone. Placenta. 2007;28:1073-81 pubmed
    ..We hypothesised that there are changes in placental Bcrp1 (the mouse orthologue of human BCRP) expression during pregnancy and that these correlate with changes in ..