BAIAP2

Summary

Gene Symbol: BAIAP2
Description: BAI1 associated protein 2
Alias: BAP2, FLAF3, IRSP53, brain-specific angiogenesis inhibitor 1-associated protein 2, IRS-58, IRSp53/58, fas ligand-associated factor 3, insulin receptor substrate of 53 kDa, insulin receptor substrate p53/p58, insulin receptor substrate protein of 53 kDa
Species: human
Products:     BAIAP2

Top Publications

  1. Weiss S, Ladwein M, Schmidt D, Ehinger J, Lommel S, Städing K, et al. IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation. Cell Host Microbe. 2009;5:244-58 pubmed publisher
    ..coli (EHEC) O157:H7 employ the bacterial effector EspF(U) (TccP), a potent N-WASP activator. Here, we show that IRSp53 family members, key regulators of membrane and actin dynamics, directly interact with both Tir and EspF(U)...
  2. Disanza A, Mantoani S, Hertzog M, Gerboth S, Frittoli E, Steffen A, et al. Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex. Nat Cell Biol. 2006;8:1337-47 pubmed
    ..How signalling pathways control and coordinate the activity of these crosslinkers is poorly defined. IRSp53, a multi-domain protein that can associate with the Rho-GTPases Rac and Cdc42, participates in these processes ..
  3. Yamagishi A, Masuda M, Ohki T, Onishi H, Mochizuki N. A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein. J Biol Chem. 2004;279:14929-36 pubmed
    Insulin receptor tyrosine kinase substrate p53 (IRSp53) has been identified as an SH3 domain-containing adaptor that links Rac1 with a Wiskott-Aldrich syndrome family verprolin-homologous protein 2 (WAVE2) to induce lamellipodia or Cdc42 ..
  4. Menna E, Disanza A, Cagnoli C, Schenk U, Gelsomino G, Frittoli E, et al. Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF). PLoS Biol. 2009;7:e1000138 pubmed publisher
  5. Suetsugu S, Murayama K, Sakamoto A, Hanawa Suetsugu K, Seto A, Oikawa T, et al. The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation. J Biol Chem. 2006;281:35347-58 pubmed
    ..The Rac binding (RCB) domain/IRSp53-MIM homology domain (IMD) has a dimeric structure that is similar to the structure of the BAR domain; however, the ..
  6. Suetsugu S, Kurisu S, Oikawa T, Yamazaki D, Oda A, Takenawa T. Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac. J Cell Biol. 2006;173:571-85 pubmed
    ..b>IRSp53 binds to both Rac and Cdc42 and is proposed to link Rac to WAVE2...
  7. Scita G, Confalonieri S, Lappalainen P, Suetsugu S. IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions. Trends Cell Biol. 2008;18:52-60 pubmed publisher
    ..of a recently discovered family of proteins, including missing-in-metastasis and ABBA (actin-bundling protein with BAIAP2 homology)...
  8. Krugmann S, Jordens I, Gevaert K, Driessens M, Vandekerckhove J, Hall A. Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex. Curr Biol. 2001;11:1645-55 pubmed
    ..The molecular mechanism for this remains as yet unclear. We report here that Cdc42 interacts with IRSp53/BAP2 alpha, an SH3 domain-containing scaffold protein, at a partial CRIB motif and that an N-terminal fragment of ..
  9. Soltau M, Richter D, Kreienkamp H. The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42. Mol Cell Neurosci. 2002;21:575-83 pubmed
    ..of the proline-rich region of shank1 in a yeast two hybrid screen, we identified the insulin receptor substrate IRSp53 as an interaction partner...

More Information

Publications83

  1. Funato Y, Terabayashi T, Suenaga N, Seiki M, Takenawa T, Miki H. IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness. Cancer Res. 2004;64:5237-44 pubmed
    b>IRSp53 has been characterized as an adaptor protein that links Rho-family small GTPases, such as Rac, to reorganization of the actin cytoskeleton...
  2. Kim M, Choi J, Yang J, Chung W, Kim J, Paik S, et al. Enhanced NMDA receptor-mediated synaptic transmission, enhanced long-term potentiation, and impaired learning and memory in mice lacking IRSp53. J Neurosci. 2009;29:1586-95 pubmed publisher
    b>IRSp53 is an adaptor protein that acts downstream of Rac and Cdc42 small GTPases and is implicated in the regulation of membrane deformation and actin filament assembly...
  3. Vingadassalom D, Kazlauskas A, Skehan B, Cheng H, Magoun L, Robbins D, et al. Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation. Proc Natl Acad Sci U S A. 2009;106:6754-9 pubmed publisher
    ..A second domain of IRTKS, the IRSp53/MIM homology domain (IMD), bound to Tir in a manner dependent on the C-terminal NPY(458) sequence, thereby ..
  4. Ribases M, Bosch R, Hervas A, Ramos Quiroga J, Sánchez Mora C, Bielsa A, et al. Case-control study of six genes asymmetrically expressed in the two cerebral hemispheres: association of BAIAP2 with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2009;66:926-34 pubmed publisher
    ..We selected six functional candidate genes showing at least 1.9-fold differential expression between hemispheres (BAIAP2, DAPPER1, LMO4, NEUROD6, ATP2B3, and ID2) and performed a case-control association study in an initial Spanish ..
  5. Choi J, Ko J, Racz B, Burette A, Lee J, Kim S, et al. Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases. J Neurosci. 2005;25:869-79 pubmed
    ..Insulin receptor substrate 53 (IRSp53), which is highly expressed in the postsynaptic density (PSD), is known to link activated Rac1/Cdc42 to downstream ..
  6. Millard T, Bompard G, Heung M, Dafforn T, Scott D, Machesky L, et al. Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53. EMBO J. 2005;24:240-50 pubmed
    The scaffolding protein insulin receptor tyrosine kinase substrate p53 (IRSp53), a ubiquitous regulator of the actin cytoskeleton, mediates filopodia formation under the control of Rho-family GTPases...
  7. Miki H, Yamaguchi H, Suetsugu S, Takenawa T. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. Nature. 2000;408:732-5 pubmed
    ..Here we demonstrate that IRSp53, a substrate for insulin receptor with unknown function, is the 'missing link' between Rac and WAVE...
  8. Abbott M, Wells D, Fallon J. The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses. J Neurosci. 1999;19:7300-8 pubmed
    ..and microsequenced, revealing that p58/53 is identical to the insulin receptor tyrosine kinase substrate p58/53 (IRSp53)...
  9. Mattila P, Pykäläinen A, Saarikangas J, Paavilainen V, Vihinen H, Jokitalo E, et al. Missing-in-metastasis and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain-like mechanism. J Cell Biol. 2007;176:953-64 pubmed
    ..We show that actin-binding proteins MIM (missing-in-metastasis) and IRSp53 directly bind PI(4,5)P(2)-rich membranes and deform them into tubular structures...
  10. Oda K, Shiratsuchi T, Nishimori H, Inazawa J, Yoshikawa H, Taketani Y, et al. Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. Cytogenet Cell Genet. 1999;84:75-82 pubmed
    ..intracellular carboxyl terminus as "bait" in a yeast two-hybrid system, we isolated a cDNA clone named BAIAP2 whose nucleotide sequence would encode a 521-amino acid protein showing significant homology to a 58/53-kDa ..
  11. Miyahara A, Okamura Oho Y, Miyashita T, Hoshika A, Yamada M. Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein. J Hum Genet. 2003;48:410-4 pubmed
    Insulin receptor tyrosine kinase substrate of 53-kDa protein (IRSp53) is now known to be a key factor in cytoskeleton reorganization...
  12. Miki H, Takenawa T. WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac. Biochem Biophys Res Commun. 2002;293:93-9 pubmed
    We previously reported that IRSp53 binds both Rac and WAVE2, inducing formation of Rac/IRSp53/WAVE2 complex that is important for membrane ruffling...
  13. Govind S, Kozma R, Monfries C, Lim L, Ahmed S. Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin. J Cell Biol. 2001;152:579-94 pubmed
    ..These results suggest that Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing protein complexes via adaptor proteins such as IRS-58 to F-actin. ..
  14. Okamura Oho Y, Miyashita T, Ohmi K, Yamada M. Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate. Hum Mol Genet. 1999;8:947-57 pubmed
    ..system was identified as a human homolog of the insulin receptor tyrosine kinase substrate protein of 53 kDa (IRSp53). The gene produced two mRNA forms by differential splicing and encoded 552 and 521 amino acids, respectively...
  15. Chen Q, Jia A, Snyder S, Gong Z, Lam S. Glucocorticoid activity detected by in vivo zebrafish assay and in vitro glucocorticoid receptor bioassay at environmental relevant concentrations. Chemosphere. 2016;144:1162-9 pubmed publisher
    ..The expression of pepck, baiap2 and pxr was up-regulated in zebrafish larvae and the expression of baiap2, pxr and mmp-2 was up-regulated in adult ..
  16. Bensen J, Graff M, Young K, Sethupathy P, Parker J, Pecot C, et al. A survey of microRNA single nucleotide polymorphisms identifies novel breast cancer susceptibility loci in a case-control, population-based study of African-American women. Breast Cancer Res. 2018;20:45 pubmed publisher
    ..gene MIR3065 and the first intron of the gene for brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2). Furthermore, miRNA-associated SNPs on chromosomes 1p32.3, 5q32, and 3p25...
  17. Jacquemet G, Stubb A, Saup R, Miihkinen M, Kremneva E, Hamidi H, et al. Filopodome Mapping Identifies p130Cas as a Mechanosensitive Regulator of Filopodia Stability. Curr Biol. 2019;29:202-216.e7 pubmed publisher
    ..Finally, we demonstrate that our map based on myosin-X-induced filopodia can be translated to endogenous filopodia and fascin- and IRSp53-mediated filopodia.
  18. Mochizuki T, Kimata Y, Uemura S, Abe F. Retention of chimeric Tat2-Gap1 permease in the endoplasmic reticulum induces unfolded protein response in Saccharomyces cerevisiae. FEMS Yeast Res. 2015;15:fov044 pubmed publisher
    ..15 amino acid residues in the transmembrane domains (TMDs) for its import activity, whereas leucine permease Bap2 requires only seven corresponding residues for its leucine import...
  19. Montesinos Rongen M, Purschke F, Brunn A, May C, Nordhoff E, Marcus K, et al. Primary Central Nervous System (CNS) Lymphoma B Cell Receptors Recognize CNS Proteins. J Immunol. 2015;195:1312-9 pubmed publisher
    ..Interestingly, proteins (GRINL1A, centaurin-α, BAIAP2) recognized by the recAbs are physiologically expressed by CNS neurons...
  20. Chuang H, Huang T, Hsueh Y. T-Brain-1--A Potential Master Regulator in Autism Spectrum Disorders. Autism Res. 2015;8:412-26 pubmed publisher
    ..We further validated the alteration of RNA expression levels of Kiaa0319, Baiap2, and Gad1 in Tbr1 deficient mice...
  21. Yu N, Ding Q, Li E, Qin J, Chen L, Wang X. Growth, energy metabolism and transcriptomic responses in Chinese mitten crab (Eriocheir sinensis) to benzo[α]pyrene (BaP) toxicity. Aquat Toxicol. 2018;203:150-158 pubmed publisher
    ..15 (BaP1) and 0.45 μg /L (BaP2) for 28 days. Crab survival and weight gain were reduced in the water born BaP in a dose-dependent way...
  22. Chen C, Shih C, Chang Y, Hong S, Li T, Wang L, et al. SH2B1 and IRSp53 proteins promote the formation of dendrites and dendritic branches. J Biol Chem. 2015;290:6010-21 pubmed publisher
    ..whether SH2B1 may regulate filopodium formation, the effect of SH2B1 and a membrane and actin regulator, IRSp53 (insulin receptor tyrosine kinase substrate p53), is investigated...
  23. Chazeau A, Mehidi A, Nair D, Gautier J, Leduc C, Chamma I, et al. Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion. EMBO J. 2014;33:2745-64 pubmed publisher
    ..The PSD is a persistent confinement zone for IRSp53 and the WAVE complex, an activator of the Arp2/3 complex...
  24. Dosemeci A, Burch A, Loo H, Toy D, Tao Cheng J. IRSp53 accumulates at the postsynaptic density under excitatory conditions. PLoS ONE. 2017;12:e0190250 pubmed publisher
    b>IRSp53 (BAIAP2) is an abundant protein at the postsynaptic density (PSD) that binds to major PSD scaffolds, PSD-95 and Shanks, as well as to F-actin...
  25. Chung W, Choi S, Lee E, Park H, Kang J, Park H, et al. Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression. Nat Neurosci. 2015;18:435-43 pubmed publisher
    ..We found that mice lacking the excitatory synaptic signaling scaffold IRSp53 (also known as BAIAP2) showed impaired social interaction and communication...
  26. Wong A, Raymond B, Collins J, Crepin V, Frankel G. The enteropathogenic E. coli effector EspH promotes actin pedestal formation and elongation via WASP-interacting protein (WIP). Cell Microbiol. 2012;14:1051-70 pubmed publisher
    ..attachment sites independently of the Tir tyrosine residues Y474 and Y454, which are implicated in binding Nck and IRSp53/ITRKS respectively...
  27. Yu J, Lin S, Wang M, Liang L, Zou Z, Zhou X, et al. Metastasis suppressor 1 regulates neurite outgrowth in primary neuron cultures. Neuroscience. 2016;333:123-31 pubmed publisher
    ..deletion of the Wiskott-Aldrich homology 2 (WH2) motif and point mutation in the insulin receptor substrate p53 (IRSp53) and MIM/MTSS1 homology (IMD) domain...
  28. Delage E, Cervantes D, Pénard E, Schmitt C, Syan S, Disanza A, et al. Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes. Sci Rep. 2016;6:39632 pubmed publisher
    ..We demonstrate that the filopodia-promoting CDC42/IRSp53/VASP network negatively regulates TNT formation and impairs TNT-mediated intercellular vesicle transfer...
  29. Mao X, Qin X, Li L, Zhou J, Zhou M, Li X, et al. A 15-long non-coding RNA signature to improve prognosis prediction of cervical squamous cell carcinoma. Gynecol Oncol. 2018;149:181-187 pubmed publisher
    ..In summary, a 15-lncRNA expression signature (BAIAP2-AS1, RP11-203J24.8, LINC01133, RP1-7G5.6, RP11-147L13.15, SERHL, CTC-537E7.3, RP11-440L14.1, RP11-131N11...
  30. Bobsin K, Kreienkamp H. Severe learning deficits of IRSp53 mutant mice are caused by altered NMDA receptor-dependent signal transduction. J Neurochem. 2016;136:752-763 pubmed publisher
    ..The insulin receptor substrate protein of 53 kDa (IRSp53, also known as Baiap2) is a signaling and adapter protein in forebrain excitatory ..
  31. Chou A, Sem K, Lam W, Ahmed S, Lim C. Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development. Sci Rep. 2017;7:40485 pubmed publisher
    The insulin receptor substrate of 53 kDa, IRSp53, is an adaptor protein that works with activated GTPases, Cdc42 and Rac, to modulate actin dynamics and generate membrane protrusions in response to cell signaling...
  32. Itoh Y, Kida K, Hanawa Suetsugu K, Suetsugu S. Yeast Ivy1p Is a Putative I-BAR-domain Protein with pH-sensitive Filament Forming Ability in vitro. Cell Struct Funct. 2016;41:1-11 pubmed publisher
    ..The BAR domains with a convex surface form a subtype called the inverse BAR (I-BAR) domain or IRSp53-MIM-homology domain (IMD)...
  33. Popov Celeketic D, Bianchi F, Ruiz S, Meutiawati F, Poolman B. A Plasma Membrane Association Module in Yeast Amino Acid Transporters. J Biol Chem. 2016;291:16024-37 pubmed publisher
    ..Using in silico analyses and mutational studies we found that the C-terminal sequences of Gap1, Bap2, Hip1, Tat1, Tat2, Mmp1, Sam3, Agp1, and Gnp1 are about 50 residues long, associate with the PM, and have features ..
  34. Chen Z, Shi Z, Baumgart T. Regulation of membrane-shape transitions induced by I-BAR domains. Biophys J. 2015;109:298-307 pubmed publisher
    ..I-BAR proteins contain an all-helical, crescent-shaped IRSp53-MIM domain (IMD) dimer that is believed to be able to couple with a membrane shape...
  35. Quansah E, Sgamma T, Jaddoa E, Zetterström T. Chronic methylphenidate regulates genes and proteins mediating neuroplasticity in the juvenile rat brain. Neurosci Lett. 2017;654:93-98 pubmed publisher
    ..such as activity regulated cytoskeleton-associated protein (Arc), insulin receptor substrate protein 53 (IRSp53), cell division control protein 42 (Cdc42), and actin-related protein 2 (Arp2)...
  36. Ferrari I, Crespi A, Fornasari D, Pietrini G. Novel localisation and possible function of LIN7 and IRSp53 in mitochondria of HeLa cells. Eur J Cell Biol. 2016;95:285-93 pubmed publisher
    ..and subcellular fractionation experiments, we here demonstrate mitochondrial distribution of LIN7 and IRSp53 in HeLa cells...
  37. McKinney B, Ding Y, Lewis D, Sweet R. DNA methylation as a putative mechanism for reduced dendritic spine density in the superior temporal gyrus of subjects with schizophrenia. Transl Psychiatry. 2017;7:e1032 pubmed publisher
    ..genes for mediating DSD abnormalities in SZ: brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) and discs large, Drosophila, homolog of, 1 (DLG1)...
  38. Vaggi F, Disanza A, Milanesi F, Di Fiore P, Menna E, Matteoli M, et al. The Eps8/IRSp53/VASP network differentially controls actin capping and bundling in filopodia formation. PLoS Comput Biol. 2011;7:e1002088 pubmed publisher
    ..the actin remodeler Eps8, whose capping and bundling activities are a function of its ligands, Abi-1 and IRSp53, respectively; VASP and Capping Protein (CP), which exert antagonistic functions in controlling filament ..
  39. Thomas A, Mariani Floderer C, López Huertas M, Gros N, Hamard Péron E, Favard C, et al. Involvement of the Rac1-IRSp53-Wave2-Arp2/3 Signaling Pathway in HIV-1 Gag Particle Release in CD4 T Cells. J Virol. 2015;89:8162-81 pubmed publisher
    ..Our results revealed the involvement of activated Rac1 and of the IRSp53-Wave2-Arp2/3 signaling pathway in HIV-1 Gag membrane localization and particle release in T cells as well as a ..
  40. Disanza A, Bisi S, Winterhoff M, Milanesi F, Ushakov D, Kast D, et al. CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP. EMBO J. 2013;32:2735-50 pubmed publisher
    ..Here, we show that the membrane deforming and curvature sensing IRSp53 (Insulin Receptor Substrate of 53?kDa) protein slows down actin filament barbed end growth...
  41. Kang J, Park H, Kim E. IRSp53/BAIAP2 in dendritic spine development, NMDA receptor regulation, and psychiatric disorders. Neuropharmacology. 2016;100:27-39 pubmed publisher
    b>IRSp53 (also known as BAIAP2) is a multi-domain scaffolding and adaptor protein that has been implicated in the regulation of membrane and actin dynamics at subcellular structures, including filopodia and lamellipodia...
  42. Sudhaharan T, Sem K, Liew H, Yu Y, Goh W, Chou A, et al. The Rho GTPase Rif signals through IRTKS, Eps8 and WAVE2 to generate dorsal membrane ruffles and filopodia. J Cell Sci. 2016;129:2829-40 pubmed publisher
    ..Based on this evidence, we propose a model in which Rho family GTPases use the I-BAR proteins, IRSp53 (also known as BAIAP2), IRTKS and Pinkbar, as a central mechanism to modulate cell morphology.
  43. Liu L, Sun L, Li Z, Li H, Wei L, Wang Y, et al. BAIAP2 exhibits association to childhood ADHD especially predominantly inattentive subtype in Chinese Han subjects. Behav Brain Funct. 2013;9:48 pubmed publisher
    ..One previous research has reported possible association between BAIAP2, which is asymmetrically expressed in the two cerebral hemispheres, with ADHD in European population...
  44. Takemura K, Hanawa Suetsugu K, Suetsugu S, Kitao A. Salt Bridge Formation between the I-BAR Domain and Lipids Increases Lipid Density and Membrane Curvature. Sci Rep. 2017;7:6808 pubmed publisher
    ..The mechanisms by which IRSp53 I-BAR binds to and deforms a lipid membrane are investigated here by all-atom molecular dynamics simulation (MD), ..
  45. Hasler R, Preti M, Meskaldji D, Prados J, Adouan W, Rodriguez C, et al. Inter-hemispherical asymmetry in default-mode functional connectivity and BAIAP2 gene are associated with anger expression in ADHD adults. Psychiatry Res Neuroimaging. 2017;269:54-61 pubmed publisher
    ..Concurrently, recent studies suggested a link between ADHD and the presence of polymorphisms within the gene BAIAP2 (i.e...
  46. Levtsova O, Davletov I, Sokolova O, Shaitan K. [A molecular dynamics study of the interaction between domain I-BAR of the IRSp53 protein and negatively charged membranes]. Biofizika. 2011;56:242-7 pubmed
    ..have been used to study specific interactions of the isolated domain I-BAR of the actin-binding protein IRSp53 and model membranes containing neutral phospholipids, as well as membranes containing high amounts of negatively ..
  47. Segal D, Dhanyasi N, Schejter E, Shilo B. Adhesion and Fusion of Muscle Cells Are Promoted by Filopodia. Dev Cell. 2016;38:291-304 pubmed publisher
    ..revealed multiple long actin-based protrusions that emanate from the myotube surface and require Enabled and IRSp53 for their generation and maintenance. Fusion is blocked when formation of these filopodia is compromised...
  48. Massari S, Perego C, Padovano V, D Amico A, Raimondi A, Francolini M, et al. LIN7 mediates the recruitment of IRSp53 to tight junctions. Traffic. 2009;10:246-57 pubmed publisher
    ..with LIN7) partner of the L27 domain but prevented TJ localization of the insulin receptor substrate p53 (IRSp53), a partner of the PDZ domain of LIN7...
  49. Prévost C, Zhao H, Manzi J, Lemichez E, Lappalainen P, Callan Jones A, et al. IRSp53 senses negative membrane curvature and phase separates along membrane tubules. Nat Commun. 2015;6:8529 pubmed publisher
    ..The inverted-BAR (I-BAR) protein IRSp53, for instance, is found on the inner leaflet of the tubular membrane of filopodia; however its role in the ..
  50. Hori K, Konno D, Maruoka H, Sobue K. MALS is a binding partner of IRSp53 at cell-cell contacts. FEBS Lett. 2003;554:30-4 pubmed
    Insulin receptor substrate p53 (IRSp53) is a key player in cytoskeletal dynamics, interacting with the actin modulators WAVE2 and Mena...
  51. He P, Yip W, Chai B, Chai B, Jabar M, Dusa N, et al. Inhibition of cell migration and invasion by miR?29a?3p in a colorectal cancer cell line through suppression of CDC42BPA mRNA expression. Oncol Rep. 2017;38:3554-3566 pubmed publisher
    ..33-fold), BAIAP2 (1.79-fold) and TIAM1 (1.77-fold), in the array were upregulated by miR?29a?3p...
  52. Lim K, Bu W, Goh W, Koh E, Ong S, Pawson T, et al. The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics. J Biol Chem. 2008;283:20454-72 pubmed publisher
    The Cdc42 effector IRSp53 is a strong inducer of filopodia formation and consists of an Src homology domain 3 (SH3), a potential WW-binding motif, a partial-Cdc42/Rac interacting binding region motif, and an Inverse-Bin-Amphiphysins-Rvs (..
  53. Lázaro Diéguez F, Cohen D, Fernandez D, Hodgson L, Van IJzendoorn S, Müsch A. Par1b links lumen polarity with LGN-NuMA positioning for distinct epithelial cell division phenotypes. J Cell Biol. 2013;203:251-64 pubmed publisher
    ..Reduced RhoA activity at the metaphase cortex in HepG2 cells and Par1b-overexpressing MDCK cells correlated with a single or no LGN-NuMA crescent, tilted spindles, and the development of lateral lumen polarity. ..
  54. Harmon B, Campbell N, Ratner L. Role of Abl kinase and the Wave2 signaling complex in HIV-1 entry at a post-hemifusion step. PLoS Pathog. 2010;6:e1000956 pubmed publisher
    ..show that Env-induced Rac activation is mediated by the Rac GEF Tiam-1, which associates with the adaptor protein IRSp53 to link Rac to the Wave2 complex...
  55. Rajagopal S, Ji Y, Xu K, Li Y, Wicks K, Liu J, et al. Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1). J Biol Chem. 2010;285:18060-71 pubmed publisher
    ..Fibroblasts express at least two Tiam1-interacting proteins, insulin receptor substrate protein 53 kDa (IRSp53) and spinophilin...
  56. Liu P, Jong T, Maa M, Leu T. The interplay between Eps8 and IRSp53 contributes to Src-mediated transformation. Oncogene. 2010;29:3977-89 pubmed publisher
    ..In this study, we observed that Eps8 modulated the expression of IRSp53 in v-Src-transformed cells (IV5), raising the question of whether Eps8/IRSp53 interaction was crucial in ..
  57. Goh W, Lim K, Sudhaharan T, Sem K, Bu W, Chou A, et al. mDia1 and WAVE2 proteins interact directly with IRSp53 in filopodia and are involved in filopodium formation. J Biol Chem. 2012;287:4702-14 pubmed publisher
    ..The RhoGTPase Cdc42 generates filopodia via IRSp53, a multidomain protein that links the processes of plasma membrane deformation and actin dynamics required for ..
  58. Pachano T, Nievas Y, Lizarraga A, Johnson P, Strobl Mazzulla P, de Miguel N. Epigenetics regulates transcription and pathogenesis in the parasite Trichomonas vaginalis. Cell Microbiol. 2017;19: pubmed publisher
    ..H3KAc) is enriched in nucleosomes positioned around the transcription start site of active genes (BAP1 and BAP2) in a highly adherent parasite strain; compared with the low acetylation abundance in contrast to that observed in ..
  59. Chou A, Sem K, Wright G, Sudhaharan T, Ahmed S. Dynamin1 is a novel target for IRSp53 protein and works with mammalian enabled (Mena) protein and Eps8 to regulate filopodial dynamics. J Biol Chem. 2014;289:24383-96 pubmed publisher
    ..Cdc42 induces filopodial formation through IRSp53, an Inverse-Bin-Amphiphysins-Rvs (I-BAR) domain protein...
  60. Morita Ishihara T, Terajima J, Watanabe H, Izumiya H. Interaction between enterohemorrhagic Escherichia coli O157:H7 EspFu and IRSp53 induces dynamic membrane remodeling in epithelial cells. Jpn J Infect Dis. 2009;62:351-5 pubmed
    ..In this study, we report that insulin receptor tyrosine kinase substrate p53 (IRSp53) in the host cell acts as a binding partner for EspFu...
  61. Misra A, Rajmohan R, Lim R, Bhattacharyya S, Thanabalu T. The mammalian verprolin, WIRE induces filopodia independent of N-WASP through IRSp53. Exp Cell Res. 2010;316:2810-24 pubmed publisher
    ..In order to characterize the WASP/N-WASP-independent function of WIRE, we screened and identified IRSp53 (Insulin Receptor Substrate) as a WIRE interacting protein...
  62. Blasche S, Arens S, Ceol A, Siszler G, Schmidt M, Häuser R, et al. The EHEC-host interactome reveals novel targets for the translocated intimin receptor. Sci Rep. 2014;4:7531 pubmed publisher
    ..In particular, we observed that EspJ is connected to the microtubule system while EspY1 appears to be involved in apoptosis/cell cycle regulation. ..
  63. Takahashi K, Suzuki K. WAVE2 targeting to phosphatidylinositol 3,4,5-triphosphate mediated by insulin receptor substrate p53 through a complex with WAVE2. Cell Signal. 2010;22:1708-16 pubmed publisher
    ..The PIP(3)-beads binding assay revealed that insulin receptor substrate p53 (IRSp53) and actin rather than WAVE2 bound to PIP(3)...
  64. Toma C, Hervas A, Balmaña N, Vilella E, Aguilera F, Cuscó I, et al. Association study of six candidate genes asymmetrically expressed in the two cerebral hemispheres suggests the involvement of BAIAP2 in autism. J Psychiatr Res. 2011;45:280-2 pubmed publisher
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    The insulin receptor substrate protein of 53 kDa (IRSp53) is crucially involved in the formation of filopodia and neurites through mechanisms that have only partially been clarified...
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    ..we found a common variant in the gene encoding the brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) that was related to the model parameter reflecting modulation of verbal memory strength by negative valence...
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    ..The insulin receptor substrate p53 (IRSp53), an Src homology 3 (SH3) adapter protein and regulator of the actin cytoskeleton, was identified as an espin-..
  68. de Groot J, Schlüter K, Carius Y, Quedenau C, Vingadassalom D, Faix J, et al. Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli. Structure. 2011;19:1294-306 pubmed publisher
    ..is triggered by the intracellular interaction of its translocated effector proteins Tir and EspF(U) with human IRSp53 family proteins and N-WASP...
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    The 53-kDa insulin receptor substrate protein (IRSp53) is part of a regulatory network that organises the actin cytoskeleton in response to stimulation by small GTPases, promoting formation of actin-rich cell protrusions such as filopodia ..
  70. Teodorof C, Bae J, Kim S, Oh H, Kang Y, Choi J, et al. SPIN90-IRSp53 complex participates in Rac-induced membrane ruffling. Exp Cell Res. 2009;315:2410-9 pubmed publisher
    ..Using the BioGRID(beta) database (General Repository for Interaction Datasets), we identified IRSp53 as a binding partner of SPIN90, and confirmed the in vivo formation of a SPIN90-IRSp53 complex mediated through ..
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    ..Kank specifically inhibits the binding of IRSp53 with active Rac1 (Rac1(G12V)) but not Cdc42 (cdc42(G12V)) and thus inhibits the IRSp53-dependent development of ..
  72. Fujiwara T, Mammoto A, Kim Y, Takai Y. Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2. Biochem Biophys Res Commun. 2000;271:626-9 pubmed
    ..We isolated an mDia1-binding protein and identified it to be IRSp53/BAIAP2...
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    Filopodia are dynamic structures found at the leading edges of most migrating cells. IRSp53 plays a role in filopodium dynamics by coupling actin elongation with membrane protrusion...
  74. Kast D, Yang C, Disanza A, Boczkowska M, Madasu Y, Scita G, et al. Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors. Nat Struct Mol Biol. 2014;21:413-22 pubmed publisher
    The Rho family GTPase effector IRSp53 has essential roles in filopodia formation and neuronal development, but its regulatory mechanism is poorly understood...