BAG2

Summary

Gene Symbol: BAG2
Description: BCL2 associated athanogene 2
Alias: BAG-2, dJ417I1.2, BAG family molecular chaperone regulator 2, bcl-2-associated athanogene 2, dJ417I1.2 (BAG-family molecular chaperone regulator 2)
Species: human
Products:     BAG2

Top Publications

  1. Dai Q, Qian S, Li H, McDonough H, Borchers C, Huang D, et al. Regulation of the cytoplasmic quality control protein degradation pathway by BAG2. J Biol Chem. 2005;280:38673-81 pubmed
    ..Using a proteomics approach, we have identified BAG2, a previously uncharacterized BAG domain-containing protein, as a common component of CHIP holocomplexes in vivo...
  2. Beilina A, Rudenko I, Kaganovich A, Civiero L, Chau H, Kalia S, et al. Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. Proc Natl Acad Sci U S A. 2014;111:2626-31 pubmed publisher
    ..We propose that three different genes for PD have a common biological function. More generally, data integration from multiple unbiased screens can provide insight into human disease mechanisms. ..
  3. Carrettiero D, Hernandez I, Neveu P, Papagiannakopoulos T, Kosik K. The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule. J Neurosci. 2009;29:2151-61 pubmed publisher
    ..Here, we report an elegant mechanism of Tau degradation involving the cochaperone BAG2. The BAG2/Hsp70 complex is tethered to the microtubule and this complex can capture and deliver Tau to the ..
  4. Xu Y, Wu Q, Chen Y, Smales R, Shi S, Wang M. Antimicrobial effects of a bioactive glass combined with fluoride or triclosan on Streptococcus mutans biofilm. Arch Oral Biol. 2015;60:1059-65 pubmed publisher
    ..The combinations of BAG with either NaF or TCS enhanced the inactivation effects of BAG (2 MBC) on S. mutans biofilm, and these findings should be further investigated clinically for the control of dental biofilms. ..
  5. Liang S, Song Z, Wu Y, Gao Y, Gao M, Liu F, et al. MicroRNA-27b Modulates Inflammatory Response and Apoptosis during Mycobacterium tuberculosis Infection. J Immunol. 2018;200:3506-3518 pubmed publisher
    ..Luciferase reporter assay and Western blotting showed that miR-27b directly targeted Bcl-2-associated athanogene 2 (Bag2) in macrophages...
  6. Dupzyk A, Tsai B. Bag2 Is a Component of a Cytosolic Extraction Machinery That Promotes Membrane Penetration of a Nonenveloped Virus. J Virol. 2018;92: pubmed publisher
    ..We now report that the nucleotide exchange factor (NEF) Bag2 stimulates SV40 release from Hsc70, thereby enabling successful virus arrival at the cytosol, which leads to ..
  7. Selmansberger M, Feuchtinger A, Zurnadzhy L, Michna A, Kaiser J, Abend M, et al. CLIP2 as radiation biomarker in papillary thyroid carcinoma. Oncogene. 2015;34:3917-25 pubmed publisher
    ..The genes comprising the first neighbourhood of CLIP2 (BAG2, CHST3, KIF3C, NEURL1, PPIL3 and RGS4) suggest the involvement of CLIP2 in the fundamental carcinogenic processes ..
  8. Taylor I, Dunyak B, Komiyama T, Shao H, Ran X, Assimon V, et al. High-throughput screen for inhibitors of protein-protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex. J Biol Chem. 2018;293:4014-4025 pubmed publisher
    ..70 (Hsp70), which is an ATP-dependent molecular chaperone that interacts with co-chaperones, including DnaJA2 and BAG2. The PPIs between Hsp70 and its co-chaperones stimulate nucleotide cycling...
  9. Hauser B, Zhao Y, Pang X, Ling Z, Myers E, Wang P, et al. Functions of MiRNA-128 on the regulation of head and neck squamous cell carcinoma growth and apoptosis. PLoS ONE. 2015;10:e0116321 pubmed publisher
    ..Our results provide a better understanding of miRNA-128 function and its potential targets, which may be valuable for developing novel diagnostic markers and targeted therapy. ..

More Information

Publications42

  1. Wang J, Du E, Tang J. The treatment of malignant glaucoma in nanophthalmos: a case report. BMC Ophthalmol. 2018;18:54 pubmed publisher
    ..This case suggests that it is essential to choose a suitable treatment for nanophthalmos patients to deal with malignant glaucoma and to reduce the incidence of malignant glaucoma. ..
  2. Schenk K, Schierl R, Angele M, Burkhart Reichl A, Glockzin G, Novotny A, et al. Cisplatin and oxaliplatin surface contamination in intensive care units (ICUs) and hospital wards during attendance of HIPEC patients. Int Arch Occup Environ Health. 2016;89:991-6 pubmed publisher
    ..Platinum concentrations from surfaces of bags and floors ranged from 0.01 to 439 pg/cm(2) (median: urine bag 2.77 pg/cm(2), drainage bag 0.22 pg/cm(2), floor left 0.14 pg/cm(2), floor right 0...
  3. de Oliveira A, Santiago F, Balioni L, Ferrari M, Almeida M, Carrettiero D. BAG2 expression dictates a functional intracellular switch between the p38-dependent effects of nicotine on tau phosphorylation levels via the α7 nicotinic receptor. Exp Neurol. 2016;275 Pt 1:69-77 pubmed publisher
    ..The co-chaperone BAG2 is capable of regulating phospho-tau levels via protein degradation...
  4. Christensen M, Lipman G, Grahn D, Shea K, Einhorn J, Heller H. A Novel Cooling Method and Comparison of Active Rewarming of Mildly Hypothermic Subjects. Wilderness Environ Med. 2017;28:108-115 pubmed publisher
    ..Although there was not a clear benefit in either of the 2 active rewarming methods, AVA rewarming showed a nonsignificant trend toward greater shivering inhibition, which may be optimized by an improved interface. ..
  5. Guan X, Chen H, Dobbelaar P, Dong Y, Fong T, Gagen K, et al. Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity. Cell Metab. 2010;11:101-12 pubmed publisher
    ..These results demonstrate that BRS-3 has a role in energy homeostasis that complements several well-known pathways and that BRS-3 agonists represent a potential approach to the treatment of obesity. ..
  6. Sauro S, Babbar A, Gharibi B, Feitosa V, Carvalho R, Azevedo Rodrigues L, et al. Cellular differentiation, bioactive and mechanical properties of experimental light-curing pulp protection materials. Dent Mater. 2018;34:868-878 pubmed publisher
    ..Thus, these materials might represent suitable therapeutic pulp protection materials for minimally invasive and atraumatic restorative treatments. ..
  7. Rahmani P, Rogalski T, Moerman D. The C. elegans UNC-23 protein, a member of the BCL-2-associated athanogene (BAG) family of chaperone regulators, interacts with HSP-1 to regulate cell attachment and maintain hypodermal integrity. Worm. 2015;4:e1023496 pubmed publisher
    ..The interaction of UNC-23 with HSP-1 defines a role for HSP-1 function in the maintenance of muscle attachment during development. ..
  8. Katzan I, Thompson N, Uchino K, Foldvary Schaefer N. A screening tool for obstructive sleep apnea in cerebrovascular patients. Sleep Med. 2016;21:70-6 pubmed publisher
    ..Addition of neck circumference and other variables did not significantly improve the models. The STOP-BAG2 model, using continuous variables, had a greater sensitivity of 0.94 (95% CI 0.89-0.98) and specificity 0...
  9. Booth L, Shuch B, Albers T, Roberts J, Tavallai M, Proniuk S, et al. Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function. Oncotarget. 2016;7:12975-96 pubmed publisher
    ..additional chaperone and chaperone-associated proteins were shown to interact with AR-12, including: GRP75, HSP75, BAG2; HSP27; ULK-1; and thioredoxin...
  10. Fukuzono T, Pastuhov S, Fukushima O, Li C, Hattori A, Iemura S, et al. Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi. Genes Cells. 2016;21:311-24 pubmed publisher
    ..We identified two human proteins that bind to LRRK2: BAG2 and HSC70, which are known to form a chaperone complex...
  11. Qu D, Hage A, Don Carolis K, Huang E, Joselin A, Safarpour F, et al. BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival. J Biol Chem. 2015;290:30441-52 pubmed publisher
    ..In this study, we identify Bcl2-associated athanogene 2 (BAG2) as a factor that promotes mitophagy. BAG2 inhibits PINK1 degradation by blocking the ubiquitination pathway...
  12. Costessi A, Mahrour N, Sharma V, Stunnenberg R, Stoel M, Tijchon E, et al. The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME. PLoS ONE. 2012;7:e42822 pubmed publisher
    ..Moreover, EKC subunits associate with PRAME target sites on chromatin. Our data reveal a novel link between the oncoprotein PRAME and the conserved EKC complex and support a role for both complexes in the same pathways. ..
  13. Zhang L, Rymer W. Reflex and intrinsic changes induced by fatigue of human elbow extensor muscles. J Neurophysiol. 2001;86:1086-94 pubmed
    ..In short, the reduced contribution from intrinsic stiffness to joint torque was compensated by increased contribution from dynamic stretch reflexes after fatigue...
  14. Che X, Tang B, Wang H, Yan X, Jiang H, Shen L, et al. The BAG2 and BAG5 proteins inhibit the ubiquitination of pathogenic ataxin3-80Q. Int J Neurosci. 2015;125:390-4 pubmed publisher
    ..Here, we report that BAG2 (Bcl-2 associated athanogene family protein 2) and BAG5 (Bcl-2-associated athanogene family protein 5) stabilise ..
  15. de Paula C, Santiago F, de Oliveira A, Oliveira F, Almeida M, Carrettiero D. The Co-chaperone BAG2 Mediates Cold-Induced Accumulation of Phosphorylated Tau in SH-SY5Y Cells. Cell Mol Neurobiol. 2016;36:593-602 pubmed publisher
    ..Under the temperature of 37 °C, the co-chaperone BAG2 protein targets phosphorylated tau for degradation via by a more-efficient, ubiquitin-independent pathway...
  16. Yue X, Zhao Y, Liu J, Zhang C, Yu H, Wang J, et al. BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function. elife. 2015;4: pubmed publisher
    ..Its underlying mechanism is poorly understood. Here, we found that BAG2, a protein of Bcl-2 associated athanogene (BAG) family, promotes mutp53 accumulation and GOF in tumors...
  17. Che X, Tang B, Wang X, Chen D, Yan X, Jiang H, et al. The BAG2 protein stabilises PINK1 by decreasing its ubiquitination. Biochem Biophys Res Commun. 2013;441:488-92 pubmed publisher
    ..Thus far, little is known about what can regulate the ubiquitin proteasome pathway of PINK1. Here, we report BAG2 (Bcl-2-associated athanogene family protein 2), a member of the BAG family, which directly binds with and ..
  18. Qin L, Guo J, Zheng Q, Zhang H. BAG2 structure, function and involvement in disease. Cell Mol Biol Lett. 2016;21:18 pubmed publisher
    Bcl2-associated athanogene 2 (BAG2) shares a similar molecular structure and function with other BAG family members...
  19. Rozenblatt Rosen O, Deo R, Padi M, Adelmant G, Calderwood M, Rolland T, et al. Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature. 2012;487:491-5 pubmed publisher
    ..Combining systems-level studies of pathogen-encoded gene products with genomic approaches will facilitate the prioritization of cancer-causing driver genes to advance the understanding of the genetic basis of human cancer...
  20. Yang K, Bae E, Ahn S, Pang K, Park Y, Park J, et al. Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells. Cell Rep. 2017;21:2952-2964 pubmed publisher
    ..Here, we report a unique role for Bcl-2-associated athanogene 2 (BAG2), which is significantly overexpressed in TNBC, in regulating the dual functions of cathepsin B as either a pro- or ..
  21. Schönbühler B, Schmitt V, Huesmann H, Kern A, Gamerdinger M, Behl C. BAG2 Interferes with CHIP-Mediated Ubiquitination of HSP72. Int J Mol Sci. 2016;18: pubmed publisher
    ..The activity of CHIP is regulated by two co-chaperones, BAG2 and HSPBP1, which are potent inhibitors of the E3 ubiquitin ligase activity...
  22. Yue X, Zhao Y, Huang G, Li J, Zhu J, Feng Z, et al. A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis. Cell Discov. 2016;2:16039 pubmed
    ..Furthermore, our results also uncovered that promoting mutp53 accumulation and GOFs is a novel mechanism of BAG5 in tumorigenesis. ..
  23. Santiago F, Almeida M, Carrettiero D. BAG2 Is Repressed by NF-κB Signaling, and Its Overexpression Is Sufficient to Shift Aβ1-42 from Neurotrophic to Neurotoxic in Undifferentiated SH-SY5Y Neuroblastoma. J Mol Neurosci. 2015;57:83-9 pubmed publisher
    ..The molecular mechanisms for this phenomenon are presently unknown. The cochaperone BAG2 has been shown to mediate important cellular responses to stress, including cell cycle arrest and apoptosis...
  24. Boruta D, Shibley T. Power Morcellation of Unsuspected High-grade Leiomyosarcoma Within an Inflated Containment Bag: 2-year Follow-up. J Minim Invasive Gynecol. 2016;23:1009-11 pubmed publisher
    ..Although further study is necessary, this technique may minimize the risk that women undergoing laparoscopic hysterectomy with morcellation have a worse prognosis when diagnosed with an unexpected malignancy. ..
  25. Halse R, Rochford J, McCormack J, Vandenheede J, Hemmings B, Yeaman S. Control of glycogen synthesis in cultured human muscle cells. J Biol Chem. 1999;274:776-80 pubmed
    ..These results demonstrate that EGF, like insulin, activates glycogen synthesis in muscle, acting principally via the PKB/GSK-3 pathway but with a contribution from a rapamycin-sensitive component that lies downstream of PI-3 kinase. ..
  26. Rauch J, Gestwicki J. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. J Biol Chem. 2014;289:1402-14 pubmed publisher
    ..Toward these questions, we measured the binding of human Hsp72 (HSPA1A) to BAG1, BAG2, BAG3, and the unrelated NEF Hsp105...
  27. Azoitei N, Hoffmann C, Ellegast J, Ball C, Obermayer K, Gößele U, et al. Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33. J Exp Med. 2012;209:697-711 pubmed publisher
  28. Keutgens A, Shostak K, Close P, Zhang X, Hennuy B, Aussems M, et al. The repressing function of the oncoprotein BCL-3 requires CtBP, while its polyubiquitination and degradation involve the E3 ligase TBLR1. Mol Cell Biol. 2010;30:4006-21 pubmed publisher
    ..Thus, our data demonstrate that the LSD1/CtBP complex is required for the repressing abilities of an oncogenic I kappaB protein, and they establish a functional link between the E3 ligase TBLR1 and NF-kappaB. ..
  29. Walker V, Atanasiu R, Lam H, Shrier A. Co-chaperone FKBP38 promotes HERG trafficking. J Biol Chem. 2007;282:23509-16 pubmed
    ..We propose that FKBP38 is a co-chaperone of HERG and contributes via the Hsc70/Hsp90 chaperone system to the trafficking of wild type and mutant HERG potassium channels. ..
  30. Arndt V, Daniel C, Nastainczyk W, Alberti S, Hohfeld J. BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP. Mol Biol Cell. 2005;16:5891-900 pubmed
    ..The presented data therefore establish multiple mechanisms to control the destructive activity of the CHIP ubiquitin ligase in human cells. ..
  31. Ueda K, Kosako H, Fukui Y, Hattori S. Proteomic identification of Bcl2-associated athanogene 2 as a novel MAPK-activated protein kinase 2 substrate. J Biol Chem. 2004;279:41815-21 pubmed
    ..Among these candidates, here we identified four proteins including Bcl-2-associated athanogene 2 (BAG2) by peptide mass fingerprintings...
  32. Takayama S, Xie Z, Reed J. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem. 1999;274:781-6 pubmed
    ..The findings suggest opportunities for specification and diversification of Hsp70/Hsc70 chaperone functions through interactions with various BAG-family proteins. ..