BAG 3

Summary

Gene Symbol: BAG 3
Description: BCL2 associated athanogene 3
Alias: BAG-3, BIS, CAIR-1, MFM6, BAG family molecular chaperone regulator 3, BCL2-binding athanogene 3, bcl-2-binding protein Bis, docking protein CAIR-1
Species: human
Products:     BAG 3

Top Publications

  1. Fuchs M, Poirier D, Seguin S, Lambert H, Carra S, Charette S, et al. Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction. Biochem J. 2009;425:245-55 pubmed publisher
  2. Zhang Y, Wang J, Lu Q, Wang Y. Bag3 promotes resistance to apoptosis through Bcl-2 family members in non-small cell lung cancer. Oncol Rep. 2012;27:109-13 pubmed publisher
    ..We conclude that NSCLC cells were protected from apoptosis through increasing Bag3 expression and consequently promoted the expression of Bcl-XL and Bcl-2. ..
  3. Festa M, Del Valle L, Khalili K, Franco R, Scognamiglio G, Graziano V, et al. BAG3 protein is overexpressed in human glioblastoma and is a potential target for therapy. Am J Pathol. 2011;178:2504-12 pubmed publisher
    ..Our data identify BAG3 as a potential marker of glial brain tumor sensitivity to therapy and thus also an attractive candidate for new molecular therapies. ..
  4. Norton N, Li D, Rieder M, Siegfried J, Rampersaud E, Zuchner S, et al. Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy. Am J Hum Genet. 2011;88:273-82 pubmed publisher
    ..Knockdown of bag3 in a zebrafish model recapitulated DCM and heart failure. We conclude that new comprehensive genomic approaches have identified rare variants in BAG3 as causative of DCM. ..
  5. Suzuki M, Iwasaki M, Sugio A, Hishiya A, Tanaka R, Endo T, et al. BAG3 (BCL2-associated athanogene 3) interacts with MMP-2 to positively regulate invasion by ovarian carcinoma cells. Cancer Lett. 2011;303:65-71 pubmed publisher
    ..The incidence of BAG3 positivity was significantly higher at advanced clinical stages of ovarian cancer than at early stages. We suggest that BAG3 binds to MMP2 to positively regulate the process of cell invasion. ..
  6. Iwasaki M, Tanaka R, Hishiya A, Homma S, Reed J, Takayama S. BAG3 directly associates with guanine nucleotide exchange factor of Rap1, PDZGEF2, and regulates cell adhesion. Biochem Biophys Res Commun. 2010;400:413-8 pubmed publisher
  7. Gentilella A, Khalili K. Autoregulation of co-chaperone BAG3 gene transcription. J Cell Biochem. 2009;108:1117-24 pubmed publisher
    ..These observations suggest that BAG3 gene expression is controlled by its own product and that this may be critical for the biological activity of BAG3 in some cell types. ..
  8. Rosati A, di Salle E, Luberto L, Quinto I, Scala G, Turco M, et al. Identification of a Btk-BAG3 complex induced by oxidative stress. Leukemia. 2009;23:823-4 pubmed publisher
  9. Ulbricht A, Eppler F, Tapia V, van der Ven P, Hampe N, Hersch N, et al. Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. Curr Biol. 2013;23:430-5 pubmed publisher

More Information

Publications66

  1. Iwasaki M, Homma S, Hishiya A, Dolezal S, Reed J, Takayama S. BAG3 regulates motility and adhesion of epithelial cancer cells. Cancer Res. 2007;67:10252-9 pubmed
    ..Thus, the high levels of BAG3 protein seen in some epithelial cancer cell lines may be relevant to mechanisms of tumor invasion and metastasis. ..
  2. Romano M, Festa M, Pagliuca G, Lerose R, Bisogni R, Chiurazzi F, et al. BAG3 protein controls B-chronic lymphocytic leukaemia cell apoptosis. Cell Death Differ. 2003;10:383-5 pubmed
  3. Seo Y, Jeon M, Lee J, Lee Y, Youn H, Ko J, et al. Bis induces growth inhibition and differentiation of HL-60 cells via up-regulation of p27. Exp Mol Med. 2005;37:624-30 pubmed
    b>Bis (Bag-3, CAIR), a Bcl-2-interacting protein, promotes the anti-apoptotic activity of Bcl-2 and increased levels of Bis have been observed in several disease models...
  4. Meng X, Kong D, Li N, Zong Z, Liu B, Du Z, et al. Knockdown of BAG3 induces epithelial-mesenchymal transition in thyroid cancer cells through ZEB1 activation. Cell Death Dis. 2014;5:e1092 pubmed publisher
    ..These results indicate BAG3 as a regulator of ZEB1 expression in EMT and as a regulator of metastasis in thyroid cancer cells, providing potential targets to prevent and/or treat thyroid cancer cell invasion and metastasis. ..
  5. Rosati A, Bersani S, Tavano F, Dalla Pozza E, De Marco M, Palmieri M, et al. Expression of the antiapoptotic protein BAG3 is a feature of pancreatic adenocarcinoma and its overexpression is associated with poorer survival. Am J Pathol. 2012;181:1524-9 pubmed publisher
    ..Our results indicate that BAG3 has a relevant role in PDAC biology, and suggest that BAG3 expression level might be a potential marker for prediction of patient outcome. ..
  6. Gentilella A, Passiatore G, Deshmane S, Turco M, Khalili K. Activation of BAG3 by Egr-1 in response to FGF-2 in neuroblastoma cells. Oncogene. 2008;27:5011-8 pubmed publisher
    ..These observations suggest a new role for BAG3 in regulation of the cell cycle. ..
  7. Gentilella A, Khalili K. BAG3 expression in glioblastoma cells promotes accumulation of ubiquitinated clients in an Hsp70-dependent manner. J Biol Chem. 2011;286:9205-15 pubmed publisher
    ..These observations provide the first evidence for an involvement of BAG3 in the ubiquitination and turnover of its partners. ..
  8. Boiani M, Daniel C, Liu X, Hogarty M, Marnett L. The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737. J Biol Chem. 2013;288:6980-90 pubmed publisher
    ..These studies identify BAG3-mediated Mcl-1 stabilization as a potential target for cancer drug discovery. ..
  9. Li N, Du Z, Zong Z, Liu B, Li C, Zhang Q, et al. PKC?-mediated phosphorylation of BAG3 at Ser187 site induces epithelial-mesenchymal transition and enhances invasiveness in thyroid cancer FRO cells. Oncogene. 2013;32:4539-48 pubmed publisher
    ..Collectively, the current study indicates that BAG3 is a novel substrate of PKC?, and PKC?-mediated phosphorylation of BAG3 is implicated in EMT and invasiveness of thyroid cancer cells. ..
  10. Fontanella B, Birolo L, Infusini G, Cirulli C, Marzullo L, Pucci P, et al. The co-chaperone BAG3 interacts with the cytosolic chaperonin CCT: new hints for actin folding. Int J Biochem Cell Biol. 2010;42:641-50 pubmed publisher
    ..To our knowledge, this is the first report showing a biologically relevant interaction between the chaperonin CCT and BAG3 protein, thus suggesting interesting involvement in the folding processes regulated by CCT. ..
  11. Chiappetta G, Ammirante M, Basile A, Rosati A, Festa M, Monaco M, et al. The antiapoptotic protein BAG3 is expressed in thyroid carcinomas and modulates apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand. J Clin Endocrinol Metab. 2007;92:1159-63 pubmed
    ..BAG3 downmodulates the apoptotic response to TRAIL in human neoplastic thyroid cells. The protein is specifically expressed in thyroid carcinomas and not in normal thyroid tissue or goiter. ..
  12. Wang H, Meng X, Liu B, Li C, Gao Y, Niu X, et al. Involvement of JNK and NF-?B pathways in lipopolysaccharide (LPS)-induced BAG3 expression in human monocytic cells. Exp Cell Res. 2012;318:16-24 pubmed publisher
    ..Overall, the data support that BAG3 is induced by LPS via JNK and NF-?B-dependent signals, and involved in monocytic cell-extracellular matrix interaction, suggesting that BAG3 may have a role in the host response to LPS stimulation. ..
  13. Staibano S, Mascolo M, Di Benedetto M, Vecchione M, Ilardi G, Di Lorenzo G, et al. BAG3 protein delocalisation in prostate carcinoma. Tumour Biol. 2010;31:461-9 pubmed publisher
    ..These results indicate that BAG3 intra-cytoplasmic delocalisation is a specific feature of cancer versus non-neoplastic prostate and a candidate new marker for prediction of prostate cancer invasiveness and behaviour. ..
  14. Brendel A, Felzen V, Morawe T, Manthey D, Behl C. Differential regulation of apoptosis-associated genes by estrogen receptor alpha in human neuroblastoma cells. Restor Neurol Neurosci. 2013;31:199-211 pubmed publisher
    ..Taken together, we identified Caspase 3, BAG1 and BAG3 as key targets of ERalpha in neuronal cells that may play a role in ERalpha-mediated neuroprotection. ..
  15. Arndt V, Dick N, Tawo R, Dreiseidler M, Wenzel D, Hesse M, et al. Chaperone-assisted selective autophagy is essential for muscle maintenance. Curr Biol. 2010;20:143-8 pubmed publisher
  16. Rosati A, Leone A, Del Valle L, Amini S, Khalili K, Turco M. Evidence for BAG3 modulation of HIV-1 gene transcription. J Cell Physiol. 2007;210:676-83 pubmed
    ..These observations reveal a previously unrecognized cell response, that is, an increase in BAG3, elicited by HIV-1 infection, and may provide a new avenue for the suppression of HIV-1 gene expression. ..
  17. Rosati A, Khalili K, Deshmane S, Radhakrishnan S, Pascale M, Turco M, et al. BAG3 protein regulates caspase-3 activation in HIV-1-infected human primary microglial cells. J Cell Physiol. 2009;218:264-7 pubmed publisher
    ..This is the first reported evidence of a role for BAG3 in the balance of death versus survival during viral infection. ..
  18. Liu P, Xu B, Li J, Lu H. BAG3 gene silencing sensitizes leukemic cells to Bortezomib-induced apoptosis. FEBS Lett. 2009;583:401-6 pubmed publisher
    ..Our results indicate that knocking down BAG3 gene is a promising new approach to enhance the therapeutic potency of Bortezomib in leukemia. ..
  19. Wang H, Meng X, Gao Y, Liu B, Niu X, Zhang H, et al. Characterization of BAG3 cleavage during apoptosis of pancreatic cancer cells. J Cell Physiol. 2010;224:94-100 pubmed publisher
    ..This novel regulation of BAG3 may have important implications for its role in apoptosis. ..
  20. Arimura T, Ishikawa T, Nunoda S, Kawai S, Kimura A. Dilated cardiomyopathy-associated BAG3 mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes. Hum Mutat. 2011;32:1481-91 pubmed publisher
    ..These observations suggested that BAG3 mutations present in 2.8% of Japanese familial DCM patients caused DCM possibly by interfering with Z-disc assembly and inducing apoptotic cell death under the metabolic stress. ..
  21. Nivon M, Abou Samra M, Richet E, Guyot B, Arrigo A, Kretz Remy C. NF-?B regulates protein quality control after heat stress through modulation of the BAG3-HspB8 complex. J Cell Sci. 2012;125:1141-51 pubmed publisher
    ..Thus NF-?B-mediated increase in the level of the BAG3-HspB8 complex leads to upregulation of aggrephagy and clearance of irreversibly damaged proteins and might increase cell survival in conditions of hyperthermia. ..
  22. Lee Y, Cui M, Yoon H, Kim H, Oh I, Lee J. Down-modulation of Bis reduces the invasive ability of glioma cells induced by TPA, through NF-?B mediated activation of MMP-9. BMB Rep. 2014;47:262-7 pubmed
    Bcl-2 interacting cell death suppressor (Bis) has been shown to have anti-apoptotic and anti-stress functions. Recently, increased Bis expression was reported to correlate with glioma aggressiveness...
  23. Carra S, Seguin S, Lambert H, Landry J. HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy. J Biol Chem. 2008;283:1437-44 pubmed
    ..We conclude that the HspB8 activity is intrinsically dependent on Bag3, a protein that may facilitate the disposal of doomed proteins by stimulating macroautophagy. ..
  24. Pagliuca M, Lerose R, Cigliano S, Leone A. Regulation by heavy metals and temperature of the human BAG-3 gene, a modulator of Hsp70 activity. FEBS Lett. 2003;541:11-5 pubmed
    ..The role of BAG-3 protein during apoptosis and cellular stress is discussed. ..
  25. Doong H, Rizzo K, Fang S, Kulpa V, Weissman A, Kohn E. CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins. J Biol Chem. 2003;278:28490-500 pubmed
    ..Furthermore, poly-ubiquitination is not sufficient for efficient proteasomal targeting of Hsp client proteins. ..
  26. Gout E, Gutkowska M, Takayama S, Reed J, Chroboczek J. Co-chaperone BAG3 and adenovirus penton base protein partnership. J Cell Biochem. 2010;111:699-708 pubmed publisher
    ..In addition, these data enrich our knowledge about the multifunctionality of the BAG3 co-chaperone. ..
  27. Odgerel Z, Sarkozy A, Lee H, McKenna C, Rankin J, Straub V, et al. Inheritance patterns and phenotypic features of myofibrillar myopathy associated with a BAG3 mutation. Neuromuscul Disord. 2010;20:438-42 pubmed publisher
    ..The study underlines the importance of parental evaluation as it may have implications for genetic counseling. ..
  28. Lee H, Cherk S, Chan S, Wong S, Tong T, Ho W, et al. BAG3-related myofibrillar myopathy in a Chinese family. Clin Genet. 2012;81:394-8 pubmed publisher
    ..772C>T. Muscle biopsy findings were suggestive of myofibrillar myopathy on light microscopy and ultrastructural studies. To our knowledge, this is the first Chinese case of Bag3opathy so far reported. ..
  29. Gamerdinger M, Hajieva P, Kaya A, Wolfrum U, Hartl F, Behl C. Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3. EMBO J. 2009;28:889-901 pubmed publisher
  30. Chiappetta G, Basile A, Arra C, Califano D, Pasquinelli R, Barbieri A, et al. BAG3 down-modulation reduces anaplastic thyroid tumor growth by enhancing proteasome-mediated degradation of BRAF protein. J Clin Endocrinol Metab. 2012;97:E115-20 pubmed publisher
    ..These results are in line with the reported ability of BAG3 to interfere with the proteasomal delivery of a number of other client proteins. ..
  31. Seidel K, Vinet J, Dunnen W, Brunt E, Meister M, Boncoraglio A, et al. The HSPB8-BAG3 chaperone complex is upregulated in astrocytes in the human brain affected by protein aggregation diseases. Neuropathol Appl Neurobiol. 2012;38:39-53 pubmed publisher
  32. Lee J, Takahashi T, Yasuhara N, Inazawa J, Kamada S, Tsujimoto Y. Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene. 1999;18:6183-90 pubmed
    ..Using a protein interaction cloning procedure, we identified a human gene designated as bis (mapped to chromosome 10q25) that encoded a novel Bcl-2-interacting protein...
  33. Kong D, Zhang Q, Meng X, Zong Z, Li C, Liu B, et al. BAG3 sensitizes cancer cells exposed to DNA damaging agents via direct interaction with GRP78. Biochim Biophys Acta. 2013;1833:3245-3253 pubmed publisher
    ..Overall, these results suggested that through direct interaction BAG3 could prevent the antiapoptotic effect of GRP78 upon genotoxic stress. ..
  34. Yang X, Tian Z, Gou W, Takahashi H, Yu M, Xing Y, et al. Bag-3 expression is involved in pathogenesis and progression of colorectal carcinomas. Histol Histopathol. 2013;28:1147-56 pubmed publisher
    ..05). Our study indicated that aberrant Bag-3 expression might be involved in colorectal adenoma-adenocarcinoma sequence and subsequent progression. ..
  35. Gamerdinger M, Kaya A, Wolfrum U, Clement A, Behl C. BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins. EMBO Rep. 2011;12:149-56 pubmed publisher
    ..Notably, aggresome-targeting by BAG3 is distinct from previously described mechanisms, as it does not depend on substrate ubiquitination...
  36. Doong H, Price J, Kim Y, Gasbarre C, Probst J, Liotta L, et al. CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70. Oncogene. 2000;19:4385-95 pubmed
    ..CAIR-1 sequence is identical, save 2 amino acids, to BAG-3 also cloned recently as Bis, a member of the bcl-2-associated athanogene family...
  37. Hishiya A, Salman M, Carra S, Kampinga H, Takayama S. BAG3 directly interacts with mutated alphaB-crystallin to suppress its aggregation and toxicity. PLoS ONE. 2011;6:e16828 pubmed publisher
    ..Our findings indicate a novel function for BAG3 in inhibiting protein aggregation caused by the genetic mutation of CRYAB responsible for human myofibrillar myopathy. ..
  38. Takayama S, Xie Z, Reed J. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem. 1999;274:781-6 pubmed
    ..The findings suggest opportunities for specification and diversification of Hsp70/Hsc70 chaperone functions through interactions with various BAG-family proteins. ..
  39. Hishiya A, Kitazawa T, Takayama S. BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress. Circ Res. 2010;107:1220-31 pubmed publisher
    ..These proteins are possible targets for further research to identify therapies for myofibrillar myopathy or other degenerative diseases. ..
  40. Ammirante M, Rosati A, Arra C, Basile A, Falco A, Festa M, et al. IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth. Proc Natl Acad Sci U S A. 2010;107:7497-502 pubmed publisher
    ..As a proof of principle, we show that treatment of a mouse xenograft tumor model with bag3siRNA-adenovirus that down-regulates bag3 results in reduced tumor growth and increased animal survival. ..
  41. Kassis J, Guancial E, Doong H, Virador V, Kohn E. CAIR-1/BAG-3 modulates cell adhesion and migration by downregulating activity of focal adhesion proteins. Exp Cell Res. 2006;312:2962-71 pubmed
    ..These results collectively indicate that CAIR-1 may negatively regulate adhesion, focal adhesion assembly, signaling, and migration via its PXXP domain. ..
  42. Franceschelli S, Rosati A, Lerose R, De Nicola S, Turco M, Pascale M. Bag3 gene expression is regulated by heat shock factor 1. J Cell Physiol. 2008;215:575-7 pubmed publisher
    ..Because of the anti-apoptotic role of BAG3 protein, these results disclose a previously unrecognized pathway, through which HSF1 maintains cell survival. ..
  43. Villard E, Perret C, Gary F, Proust C, Dilanian G, Hengstenberg C, et al. A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy. Eur Heart J. 2011;32:1065-76 pubmed publisher
    ..Our results show that rare mutations in BAG3 contribute to monogenic forms of the disease, while common variant(s) in the same gene are implicated in sporadic DCM. ..
  44. Liao Q, Ozawa F, Friess H, Zimmermann A, Takayama S, Reed J, et al. The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines. FEBS Lett. 2001;503:151-7 pubmed
    Pancreatic cancer cells are usually resistant to apoptosis mediated by intrinsic or extrinsic factors. BAG-3 (Bis, CAIR), which was identified as a BAG-1-related protein, is a novel modulator of cellular anti-apoptotic activity that ..
  45. Selcen D, Muntoni F, Burton B, Pegoraro E, Sewry C, Bite A, et al. Mutation in BAG3 causes severe dominant childhood muscular dystrophy. Ann Neurol. 2009;65:83-9 pubmed publisher
    ..We conclude mutation in Bag3 defines a novel severe autosomal dominant childhood muscular dystrophy. ..
  46. Falco A, Festa M, Basile A, Rosati A, Pascale M, Florenzano F, et al. BAG3 controls angiogenesis through regulation of ERK phosphorylation. Oncogene. 2012;31:5153-61 pubmed publisher
  47. Rosati A, Graziano V, De Laurenzi V, Pascale M, Turco M. BAG3: a multifaceted protein that regulates major cell pathways. Cell Death Dis. 2011;2:e141 pubmed publisher
    ..This review attempts to outline the emerging mechanisms that can underlie some of the biological activities of the protein, focusing on implications in tumor progression. ..
  48. Wang H, Liu H, Zhang H, Guan Y, Du Z. Transcriptional upregulation of BAG3 upon proteasome inhibition. Biochem Biophys Res Commun. 2008;365:381-5 pubmed
    ..Taken together, our results suggest that BAG3 induction might represents as an unwanted molecular consequence of utilizing proteasome inhibitors to combat tumors. ..
  49. Xiao H, Cheng S, Tong R, Lv Z, Ding C, Du C, et al. BAG3 regulates epithelial-mesenchymal transition and angiogenesis in human hepatocellular carcinoma. Lab Invest. 2014;94:252-61 pubmed publisher
    ..In conclusion, BAG3 is associated with the invasiveness and angiogenesis in HCC, and the BAG3 gene may be a novel therapeutic approach against HCC. ..
  50. Bozzatello P, Rocca P, Uscinska M, Bellino S. Efficacy and Tolerability of Asenapine Compared with Olanzapine in Borderline Personality Disorder: An Open-Label Randomized Controlled Trial. CNS Drugs. 2017;31:809-819 pubmed publisher
    ..Scale (SOFAS), Borderline Personality Disorder Severity Index (BPDSI), Barratt Impulsiveness Scale, version 11 (BIS-11), Modified Overt Aggression Scale (MOAS), Self-Harm Inventory (SHI), and Dosage Record and Treatment Emergent ..
  51. Becerril J, Benítez J, Juárez J, Bañales J, Zerón H, Navarro M. Evaluation of the Effect of 1,3-Bis(4-Phenyl)-1H-1,2,3-Triazolyl-2-Propanolol on Gene Expression Levels of JAK2-STAT3, NF-κB, and SOCS3 in Cells Cultured from Biopsies of Mammary Lesions. Biochem Genet. 2015;53:291-300 pubmed publisher
  52. López D, Robles Hernández B, Salud J, de la Fuente M, Sebastián N, Diez Berart S, et al. Miscibility studies of two twist-bend nematic liquid crystal dimers with different average molecular curvatures. A comparison between experimental data and predictions of a Landau mean-field theory for the NTB-N phase transition. Phys Chem Chem Phys. 2016;18:4394-404 pubmed publisher
    We report a calorimetric study of a series of mixtures of two twist-bend liquid crystal dimers, the 1'',7''-bis(4-cyanobiphenyl)-4'-yl heptane (CB7CB) and 1''-(2',4-difluorobiphenyl-4'-yloxy)-9''-(4-cyanobiphenyl-4'-yloxy) nonane (..
  53. Song Y, Fan R, Fan J, Xing K, Du X, Wang P, et al. Highly sensitive and selective fluorescent probes for Hg2+ in Ag(i)/Cu(ii) 3D supramolecular architectures based on noncovalent interactions. Dalton Trans. 2016;45:16422-16432 pubmed
    ..acid; 2,2'-H2pdc = 2,2'-biphenyldicarboxylic acid; 4,4'-bpy = 4,4'-bipyridine; 1,4-bib = 1,4-bis(1-imidazolyl)benzene] have been hydrothermally synthesized by using mixed ligands and characterized by single ..
  54. Mukhopadhyay A, Maka V, Moorthy J. Remarkable influence of 'phane effect' on the excited-state properties of cofacially oriented coumarins. Phys Chem Chem Phys. 2017;19:4758-4767 pubmed publisher
    A comprehensive investigation of the photophysics of a cofacially oriented bis-coumarin based on naphthalene, i.e...
  55. Fonseca S, Padilha N, Thurow S, Roehrs J, Savegnago L, de Souza M, et al. Ultrasound-promoted copper-catalyzed synthesis of bis-arylselanyl chrysin derivatives with boosted antioxidant and anticancer activities. Ultrason Sonochem. 2017;39:827-836 pubmed publisher
    ..Semi-synthetic 6,8-bis(o-tolylselanyl)-chrysin 3b has the best radical scavenging activity of DPPH (Imax: 39...
  56. Kessler J, Iluc V. NI(ii) phosphine and phosphide complexes supported by a PNP-pyrrole pincer ligand. Dalton Trans. 2017;46:12125-12131 pubmed publisher
    The reaction between [(PNpyrP)NiCl] (1, PNpyrP = 2,5-bis((di-iso-propylphosphino)-methyl)-1H-pyrrolide) and TlPF6 in the presence of a monodentate phosphine ligand led to cationic nickel phosphine and ..
  57. Rixin Wang S, Arrowsmith M, Braunschweig H, Dewhurst R, Paprocki V, Winner L. CuOTf-mediated intramolecular diborene hydroarylation. Chem Commun (Camb). 2017;53:11945-11947 pubmed publisher
    Upon complexation to CuOTf, a PMe3-stabilized bis(9-anthryl) diborene slowly undergoes an intramolecular hydroarylation reaction at room temperature...