BACH1

Summary

Gene Symbol: BACH1
Description: BTB domain and CNC homolog 1
Alias: BACH-1, BTBD24, transcription regulator protein BACH1, BTB and CNC homology 1, basic leucine zipper transcription factor 1, basic region leucine zipper transcriptional regulator BACH1
Species: human
Products:     BACH1

Top Publications

  1. Oyake T, Itoh K, Motohashi H, Hayashi N, Hoshino H, Nishizawa M, et al. Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol Cell Biol. 1996;16:6083-95 pubmed
    ..yeast two-hybrid screen with a GAL4-MafK fusion protein, we have identified two novel bZip transcription factors, Bach1 and Bach2, as heterodimerization partners of MafK...
  2. Suzuki H, Tashiro S, Hira S, Sun J, Yamazaki C, Zenke Y, et al. Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1. EMBO J. 2004;23:2544-53 pubmed
    b>Bach1 is a transcriptional repressor of heme oxygenase-1 and beta-globin genes, both of which are known to be transcriptionally induced by heme...
  3. Dhakshinamoorthy S, Jain A, Bloom D, Jaiswal A. Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants. J Biol Chem. 2005;280:16891-900 pubmed
    ..In this report, we demonstrate that overexpression of the transcription factor Bach1 in Hep-G2 cells negatively regulated NQO1 gene expression and induction in response to antioxidant t-BHQ...
  4. Ghaziani T, Shan Y, Lambrecht R, Donohue S, Pietschmann T, Bartenschlager R, et al. HCV proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells. J Hepatol. 2006;45:5-12 pubmed
    ..Other recent work has implicated Bach1, a heme binding protein that represses gene expression, in the regulation of HO-1 gene expression...
  5. Zenke Kawasaki Y, Dohi Y, Katoh Y, Ikura T, Ikura M, Asahara T, et al. Heme induces ubiquitination and degradation of the transcription factor Bach1. Mol Cell Biol. 2007;27:6962-71 pubmed
    The transcription repressor Bach1 is a sensor and effector of heme that regulates the expression of heme oxygenase 1 and globin genes. Heme binds to Bach1, inhibiting its DNA binding activity and inducing its nuclear export...
  6. Reichard J, Sartor M, Puga A. BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite. J Biol Chem. 2008;283:22363-70 pubmed publisher
    ..In the absence of elevated intracellular heme or oxidative stress, the basic region leucine zipper transcriptional regulator BACH1 binds HMOX1 antioxidant response elements and represses transcription...
  7. Miyazaki T, Kirino Y, Takeno M, Samukawa S, Hama M, Tanaka M, et al. Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1. Cancer Sci. 2010;101:1409-16 pubmed publisher
    ..cells and normal monocytes, and its regulatory mechanism by the transcriptional repressor, BTB and CNC homology 1 (Bach1), and the activator, nuclear factor erythroid-derived 2 related factor 2 (Nrf2)...
  8. Fader K, Nault R, Kirby M, Markous G, Matthews J, Zacharewski T. Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity. Toxicol Appl Pharmacol. 2017;321:1-17 pubmed publisher
    ..Consistent with this heme accumulation, differential gene expression suggests that heme activated BACH1 and REV-ERBα/β, causing induction of heme oxygenase 1 (Hmox1) and repression of fatty acid biosynthesis, ..
  9. Lopes R, Neves K, Tostes R, Montezano A, Touyz R. Downregulation of Nuclear Factor Erythroid 2-Related Factor and Associated Antioxidant Genes Contributes to Redox-Sensitive Vascular Dysfunction in Hypertension. Hypertension. 2015;66:1240-50 pubmed publisher
    ..activity of superoxide dismutase-1, catalase, and thioredoxin in WKY but not in SHRSP, which exhibited increased Bach1 expression. Nrf2 activators blocked angiotensin II-induced reactive oxygen species generation...

More Information

Publications164 found, 100 shown here

  1. Gęgotek A, Skrzydlewska E. The role of transcription factor Nrf2 in skin cells metabolism. Arch Dermatol Res. 2015;307:385-96 pubmed publisher
    ..g., Maf, IKKβ) or inhibitors (e.g., Bach1, caveolae, TGF-β). Moreover, there are a number of drugs (e.g...
  2. Cui Y, Liu K, Liang Y, Ip M, Mak J. Inhibition of monoamine oxidase-B by selegiline reduces cigarette smoke-induced oxidative stress and inflammation in airway epithelial cells. Toxicol Lett. 2017;268:44-50 pubmed publisher
    ..erythroid 2 related factor 2 (Nrf2) and cytosol translocation of its negative regulator, BTB and CNC homolog 1 (Bach1)...
  3. Takeda T, Sasai M, Adachi Y, Ohnishi K, Fujisawa J, Izawa S, et al. Potential role of heme metabolism in the inducible expression of heme oxygenase-1. Biochim Biophys Acta Gen Subj. 2017;1861:1813-1824 pubmed publisher
    ..and translational levels, and was mediated by the activation of the heme-binding transcriptional repressor Bach1 and translational factor HRI...
  4. Silva Palacios A, Ostolga Chavarría M, Zazueta C, Konigsberg M. Nrf2: Molecular and epigenetic regulation during aging. Ageing Res Rev. 2018;47:31-40 pubmed publisher
    ..in the levels or activity of Keap1 (Kelch-like ECH associated protein 1), GSK-3β (glycogen synthase kinase-3), Bach1, p53, Hrd1 (E3 ubiquitin ligase) and miRNAs might impact on Nrf2 activity during elderly...
  5. Pomatto L, Cline M, Woodward N, Pakbin P, Sioutas C, Morgan T, et al. Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles ('vehicular smog'). Free Radic Biol Med. 2018;121:86-97 pubmed publisher
    ..We also found a parallel age-associated rise in the Nrf2 transcriptional inhibitors, Bach1 and c-Myc which appear to attenuate adaptive responses in older mammals, possibly explaining the 'age-ceiling ..
  6. Pomatto L, Davies K. The role of declining adaptive homeostasis in ageing. J Physiol. 2017;: pubmed publisher
    ..Emerging work points to Nrf2-Keap1 signal transduction pathway inhibitors, including Bach1 and c-Myc, both of whose tissue concentrations increase with age, as possible major causes for age-dependent loss ..
  7. Escalera Cueto M, Medina Martínez I, Del Angel R, Berumen Campos J, Gutiérrez Escolano A, Yocupicio Monroy M. Let-7c overexpression inhibits dengue virus replication in human hepatoma Huh-7 cells. Virus Res. 2015;196:105-12 pubmed publisher
    ..Additionally, we found that the transcription factor BACH1, a let-7c target, is also down-regulated during DENV infection...
  8. Ishitobi H, Sanada Y, Kato Y, Ikuta Y, Shibata S, Yamasaki S, et al. Carnosic acid attenuates cartilage degeneration through induction of heme oxygenase-1 in human articular chondrocytes. Eur J Pharmacol. 2018;830:1-8 pubmed publisher
    ..HO-1 by CA was in part associated with downregulation via miR-140 binding to 3'UTR of BTB and CNC homology 1 (BACH1)...
  9. Mehta N, Reddy S. Role of hemoglobin/heme scavenger protein hemopexin in atherosclerosis and inflammatory diseases. Curr Opin Lipidol. 2015;26:384-7 pubmed publisher
    ..Recent studies demonstrate that Hx-dependent uptake of extracellular heme leads to the deactivation of Bach1 repression leading to the transcriptional activation of antioxidant heme oxygenase-1 gene...
  10. Boylston J, Brenner C. A knockdown with smoke model reveals FHIT as a repressor of Heme oxygenase 1. Cell Cycle. 2014;13:2913-30 pubmed publisher
    ..with a mechanism in which Fhit protein is required for accumulation of the transcriptional repressor of HMOX1, Bach1 protein...
  11. Spies M. Two steps forward, one step back: determining XPD helicase mechanism by single-molecule fluorescence and high-resolution optical tweezers. DNA Repair (Amst). 2014;20:58-70 pubmed publisher
    ..mechanism will be discussed along with possible modifications to this mechanism by the helicase interacting partners and unique features of such bio-medically important XPD-like helicases as FANCJ (BACH1), RTEL1 and CHLR1 (DDX11).
  12. Li H, Jiang N, Liu Q, Gao A, Zhou X, Liang B, et al. Topical treatment of green tea polyphenols emulsified in carboxymethyl cellulose protects against acute ultraviolet light B-induced photodamage in hairless mice. Photochem Photobiol Sci. 2016;15:1264-1271 pubmed
    ..also discovered the ability of GTPs to simultaneously trigger accumulation of nuclear Nrf2 and export of nuclear Bach1. Altogether, our findings reinforced the putative application of GTPs in the prevention/minimization of the ..
  13. Zhou L, Zhang H, Davies K, Forman H. Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells. Redox Biol. 2018;14:35-40 pubmed publisher
    ..Furthermore, we found that the basal expression of both Bach1 and c-Myc, two Nrf2 suppressors, was higher in cells from older adults than from young adult donors...
  14. Seguin A, Takahashi Makise N, Yien Y, Huston N, Whitman J, Musso G, et al. Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes. J Biol Chem. 2017;292:16284-16299 pubmed publisher
    ..an alteration in the heme biosynthesis transcriptional profile due to repression by the transcriptional regulator Bach1, which could be partially rescued by overexpression of Alas2 or Gata1, providing a mechanistic explanation for why ..
  15. Zhao Z, Xie J, Liu B, Ge X, Song C, Ren M, et al. The effects of emodin on cell viability, respiratory burst and gene expression of Nrf2-Keap1 signaling molecules in the peripheral blood leukocytes of blunt snout bream (Megalobrama amblycephala). Fish Shellfish Immunol. 2017;62:75-85 pubmed publisher
    ..Furthermore, sharp increase in Keap1and Bach1 expression levels were observed a dose-dependent manner...
  16. Pomatto L, Sun P, Yu K, Gullapalli S, Bwiza C, Sisliyan C, et al. Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing. Redox Biol. 2019;24:101194 pubmed publisher
    ..Levels of Two major Nrf2 inhibitors, Bach1 and c-Myc, were strongly elevated by hyperoxia and appeared to exert a ceiling on Nrf2 signaling...
  17. Maruyama A, Mimura J, Itoh K. Non-coding RNA derived from the region adjacent to the human HO-1 E2 enhancer selectively regulates HO-1 gene induction by modulating Pol II binding. Nucleic Acids Res. 2014;42:13599-614 pubmed publisher
    ..Conversely, knockdown of BACH1, a repressor of HO-1 transcription, further increased DEM-inducible eRNA E2-3 transcription as well as HO-1 ..
  18. Omrani M, Yaqubi M, Mohammadnia A. Transcription Factors in Regulatory and Protein Subnetworks during Generation of Neural Stem Cells and Neurons from Direct Reprogramming of Non-fibroblastic Cell Sources. Neuroscience. 2018;380:63-77 pubmed publisher
    ..iNSCs, combination of centrality with active modules or protein complex analyses highlighted the role of POU3F2, BACH1, AR, PBX1, SOX2 and NANOG genes in this conversion...
  19. Lim J, Song M, Cho Y, Kim W, Han S, Ryu J. Comparative analysis of microRNA and mRNA expression profiles in cells and exosomes under toluene exposure. Toxicol In Vitro. 2017;41:92-101 pubmed publisher
    ..the differentially expressed miRNAs under toluene exposure (EXOSC6, RHOH, GFER, HERC2, GOLGA4, SLC7A11, GCLM, and BACH1) are related to diverse disease categories such as nervous system disease, cancer, cardiovascular disease, and ..
  20. Poulet B, Beier F. Targeting oxidative stress to reduce osteoarthritis. Arthritis Res Ther. 2016;18:32 pubmed publisher
    ..A new study implicates the transcriptional repressor Bach-1 and its downstream target HO-1 as important players in this process. ..
  21. Chakraborty A, Katarkar A, Chaudhuri K, Mukhopadhyay A, Basak J. Detection of a novel mutation in exon 20 of the BRCA1 gene. Cell Mol Biol Lett. 2013;18:631-8 pubmed publisher
    ..5237A>C), which was found in BRCA1 exon 20 of a breast cancer patient. In silico analysis suggests that this mutation could alter the stability and orientation of the BRCT domain and the differential binding of the BACH1 substrate.
  22. Datar I, Tegegne H, Qin K, Al Mulla F, Bitar M, Trumbly R, et al. Genetic and epigenetic control of RKIP transcription. Crit Rev Oncog. 2014;19:417-30 pubmed
    ..EZH2, a component of the polycomb repressive complex 2 (PRC2) and sequence specific transcription factors (TFs) BACH1 and Snail...
  23. Tanimura N, Miller E, Igarashi K, Yang D, Burstyn J, Dewey C, et al. Mechanism governing heme synthesis reveals a GATA factor/heme circuit that controls differentiation. EMBO Rep. 2016;17:249-65 pubmed publisher
    ..Heme amplifies GATA-1 function by downregulating the heme-sensing transcriptional repressor Bach1 and via a Bach1-insensitive mechanism...
  24. Köglsberger S, Cordero Maldonado M, Antony P, Forster J, Garcia P, Buttini M, et al. Gender-Specific Expression of Ubiquitin-Specific Peptidase 9 Modulates Tau Expression and Phosphorylation: Possible Implications for Tauopathies. Mol Neurobiol. 2017;54:7979-7993 pubmed publisher
    ..we derive a data-congruent model for a USP9-dependent regulatory mechanism modulating MAPT expression via BACH1 and SMAD4...
  25. Xu I, Lai R, Lin S, Tse A, Chiu D, Koh H, et al. Transketolase counteracts oxidative stress to drive cancer development. Proc Natl Acad Sci U S A. 2016;113:E725-34 pubmed publisher
    ..the Nuclear Factor, Erythroid 2-Like 2 (NRF2)/Kelch-Like ECH-Associated Protein 1 (KEAP1)/BTB and CNC Homolog 1 (BACH1) oxidative stress sensor pathway in cancers...
  26. Katsuoka F, Yamamoto M. Small Maf proteins (MafF, MafG, MafK): History, structure and function. Gene. 2016;586:197-205 pubmed publisher
    ..heterodimers with cap 'n' collar (CNC) proteins (p45 NF-E2, Nrf1, Nrf2, and Nrf3) and also with Bach proteins (Bach1 and Bach2)...
  27. Tseng C, Lin C, Chen Y, Tseng C, Lee J, Lee J. Discovery of naphtho[1,2-d]oxazole derivatives as potential anti-HCV agents through inducing heme oxygenase-1 expression. Eur J Med Chem. 2018;143:970-982 pubmed publisher
    ..We further found that compound 18 reduced bach1 expression resulting in increasing the activity of Nrf-2 binding element...
  28. Fang M, Ou J, Hutchinson L, Green M. The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype. Mol Cell. 2014;55:904-915 pubmed publisher
    ..promoters of MLH1 and other CIMP genes, and recruits a corepressor complex that includes its heterodimeric partner BACH1, the chromatin remodeling factor CHD8, and the DNA methyltransferase DNMT3B, resulting in hypermethylation and ..
  29. Tili E, Mezache L, Michaille J, Amann V, Williams J, Vandiver P, et al. microRNA 155 up regulation in the CNS is strongly correlated to Down's syndrome dementia. Ann Diagn Pathol. 2018;34:103-109 pubmed publisher
    ..Chromosome 21 genes APP/BA-42, DYRK1a and BACH1 were not correlated to pathologic changes in Down's dementia...
  30. Jiao Y, Watts T, Xue J, Hannafon B, Ding W. Sorafenib and docosahexaenoic acid act in synergy to suppress cancer cell viability: a role of heme oxygenase 1. BMC Cancer. 2018;18:1042 pubmed publisher
    ..recently reported that DHA induces HO-1 gene transcription in human cancer cells by augmenting the degradation of Bach1 protein, which functions as a negative regulator of HO-1...
  31. Tsuneyoshi T, Kunimura K, Morihara N. S-1-Propenylcysteine augments BACH1 degradation and heme oxygenase 1 expression in a nitric oxide-dependent manner in endothelial cells. Nitric Oxide. 2019;84:22-29 pubmed publisher
    ..Additionally, NO-donors induced the degradation of BTB domain and CNC homolog 1 (BACH1), a transcriptional repressor that can compete with NRF2...
  32. Fuse Y, Nakajima H, Nakajima Takagi Y, Nakajima O, Kobayashi M. Heme-mediated inhibition of Bach1 regulates the liver specificity and transience of the Nrf2-dependent induction of zebrafish heme oxygenase 1. Genes Cells. 2015;20:590-600 pubmed publisher
    ..of hmox1a was observed ectopically in nonliver tissues and persisted longer than normal fish, suggesting that Bach1 is the only regulator for both the liver-specific and transient induction of hmox1a...
  33. Zhang D, Zhang L, Zhao X, Sun W. Neuroprotective effects of erythropoietin against sevoflurane-induced neuronal apoptosis in primary rat cortical neurons involving the EPOR-Erk1/2-Nrf2/Bach1 signal pathway. Biomed Pharmacother. 2017;87:332-341 pubmed publisher
    ..studies have shown that alteration of the nuclear factor erythroid 2-related factor (Nrf2)/BTB-to-CNC homology 1 (Bach1) ratio by extracellular signal-related kinases (Erk) 1/2 ameliorates the oxidative stress which occurs in human ..
  34. El Deek H, Ahmed A, Mohammed R. Aberration of Nrf2‑Bach1 pathway in colorectal carcinoma; role in carcinogenesis and tumor progression. Ann Diagn Pathol. 2019;38:138-144 pubmed publisher
    Nrf2 and Bach1 are important transcriptional factors that protect against reactive oxygen species (ROS)...
  35. Haldar M, Kohyama M, So A, Kc W, Wu X, Briseño C, et al. Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages. Cell. 2014;156:1223-1234 pubmed publisher
    ..Spic expression in monocytes was constitutively inhibited by the transcriptional repressor BACH1. Heme induced proteasome-dependent BACH1 degradation and rapid Spic derepression...
  36. Fang M, Hutchinson L, Deng A, Green M. Common BRAF(V600E)-directed pathway mediates widespread epigenetic silencing in colorectal cancer and melanoma. Proc Natl Acad Sci U S A. 2016;113:1250-5 pubmed publisher
    ..that includes its heterodimeric partner BTB and CNC homology 1, basic leucine zipper transcription factor 1 (BACH1), the chromatin remodeling factor chromodomain helicase DNA-binding protein 8 (CHD8), and the DNA ..
  37. Jez M, Ciesla M, Stepniewski J, Langrzyk A, Muchova L, Vitek L, et al. Valproic acid downregulates heme oxygenase-1 independently of Nrf2 by increasing ubiquitination and proteasomal degradation. Biochem Biophys Res Commun. 2017;485:160-166 pubmed publisher
    ..of HO-1 expression through ARE sequence, was excluded as a mediator of HO-1 decrease, as VA downregulated Bach1, a Nrf2 repressor, concomitantly upregulating ARE activation...
  38. Dorresteijn M, Paine A, Zilian E, Fenten M, Frenzel E, Janciauskiene S, et al. Cell-type-specific downregulation of heme oxygenase-1 by lipopolysaccharide via Bach1 in primary human mononuclear cells. Free Radic Biol Med. 2015;78:224-32 pubmed publisher
    ..Notably, LPS upregulated expression of Bach1, a critical transcriptional repressor of HO-1...
  39. Bukowska Strakova K, Ciesla M, Szade K, Nowak W, Straka R, Szade A, et al. Reprint of: Heme oxygenase 1 affects granulopoiesis in mice through control of myelocyte proliferation. Immunobiology. 2017;222:846-857 pubmed publisher
    ..This was concomitant with up-regulation of miR-155, which targets Bach1, the HO-1 repressor...
  40. Slater S, Jover E, Martello A, Mitić T, Rodriguez Arabaolaza I, Vono R, et al. MicroRNA-532-5p Regulates Pericyte Function by Targeting the Transcription Regulator BACH1 and Angiopoietin-1. Mol Ther. 2018;26:2823-2837 pubmed publisher
    ..inhibitory targets associated with angiopoietin-1 transcription indicated three potential candidates, BACH1, HIF1AN, and EGLN1. Binding of microRNA-532-5p to the BACH1 3' UTR was confirmed by luciferase assay...
  41. Li X, Sun Y, Huang S, Chen Y, Chen X, Li M, et al. Inhibition of AZIN2-sv induces neovascularization and improves prognosis after myocardial infarction by blocking ubiquitin-dependent talin1 degradation and activating the Akt pathway. EBioMedicine. 2019;39:69-82 pubmed publisher
    ..With regard to the upstream mechanism, Bach1, a negative regulator of angiogenesis, bound to the promoter of AZIN2-sv and increased its expression...
  42. Jiang L, Yin M, Wei X, Liu J, Wang X, Niu C, et al. Bach1 Represses Wnt/β-Catenin Signaling and Angiogenesis. Circ Res. 2015;117:364-375 pubmed publisher
    Wnt/β-catenin signaling has an important role in the angiogenic activity of endothelial cells (ECs). Bach1 is a transcription factor and is expressed in ECs, but whether Bach1 regulates angiogenesis is unknown...
  43. Igarashi K, Itoh Nakadai A. Orchestration of B lymphoid cells and their inner myeloid by Bach. Curr Opin Immunol. 2016;39:136-42 pubmed publisher
    ..In addition, Bach2 and its related factor Bach1 promote B cell commitment of progenitor cells by repressing myeloid-related genes...
  44. Wu G, Cao L, Zhu J, Tan Z, Tang M, Li Z, et al. Loss of RBMS3 Confers Platinum Resistance in Epithelial Ovarian Cancer via Activation of miR-126-5p/β-catenin/CBP signaling. Clin Cancer Res. 2019;25:1022-1035 pubmed publisher
    ..miR-126-5p/β-catenin/CBP signaling and the effects of RBMS3 and miR-126-5p competitively regulating DKK3, AXIN1, BACH1, and NFAT5 was explored using CLIP-seq, RIP, electrophoretic mobility shift, and immunoblotting and ..
  45. Naito Y, Takagi T, Higashimura Y. Heme oxygenase-1 and anti-inflammatory M2 macrophages. Arch Biochem Biophys. 2014;564:83-8 pubmed publisher
    ..transcriptional factors and signaling cascades are involved in HO-1 regulation, the two main pathways of Nrf2/Bach1 system and IL-10/HO-1 axis exist in monocyte/macrophage...
  46. Cha Y, Lee J, Han H, Kim B, Kang S, Choi Y, et al. MicroRNA alteration and putative target genes in high-grade prostatic intraepithelial neoplasia and prostate cancer: STAT3 and ZEB1 are upregulated during prostate carcinogenesis. Prostate. 2016;76:937-47 pubmed publisher
    ..As putative target mRNAs, mRNA expression level of STAT3, ZEB1, and BACH1 was increased in PCa and HGPIN compared to NPT...
  47. Go H, La P, Namba F, Ito M, Yang G, Brydun A, et al. MiR-196a regulates heme oxygenase-1 by silencing Bach1 in the neonatal mouse lung. Am J Physiol Lung Cell Mol Physiol. 2016;311:L400-11 pubmed publisher
    ..miR-196a, which binds to the 3'-untranslated region of the transcriptional repressor BTB and CNC homology 1 (Bach1) and regulates its expression, and subsequently leads to higher levels of lung HO-1 mRNA compared with levels in ..
  48. Kanzaki H, Shinohara F, Itohiya K, Yamaguchi Y, Katsumata Y, Matsuzawa M, et al. RANKL induces Bach1 nuclear import and attenuates Nrf2-mediated antioxidant enzymes, thereby augmenting intracellular reactive oxygen species signaling and osteoclastogenesis in mice. FASEB J. 2017;31:781-792 pubmed publisher
    ..Knockout mice of BTB and CNC homology 1 (Bach1)-the competitor for Nrf2 in transcriptional regulation-was known to attenuate RANKL-mediated osteoclastogenesis, ..
  49. Yamaoka M, Shimizu H, Takahashi T, Omori E, Morimatsu H. Dynamic changes in Bach1 expression in the kidney of rhabdomyolysis-associated acute kidney injury. PLoS ONE. 2017;12:e0180934 pubmed publisher
    ..BTB and CNC homology 1 (Bach1) is a heme-responsive transcription factor that represses HO-1...
  50. Kato H, Itoh Nakadai A, Matsumoto M, Ishii Y, Watanabe Matsui M, Ikeda M, et al. Infection perturbs Bach2- and Bach1-dependent erythroid lineage 'choice' to cause anemia. Nat Immunol. 2018;19:1059-1070 pubmed publisher
    ..Here we found that the transcription factors (TFs) Bach2 and Bach1 promoted erythropoiesis by regulating heme metabolism in committed erythroid cells to sustain erythroblast ..
  51. Shiozaki E, Gu L, Yan N, Shi Y. Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling. Mol Cell. 2004;14:405-12 pubmed
    The recognition of the phosphorylated BACH1 helicase by the BRCA1 C-terminal (BRCT) repeats is important to the tumor suppressor function of BRCA1...
  52. Muñoz A, Villagrán M, Guzmán P, Solíz C, Gatica M, Aylwin C, et al. Cis-regulatory elements involved in species-specific transcriptional regulation of the SVCT1 gene in rat and human hepatoma cells. Free Radic Biol Med. 2015;85:183-96 pubmed publisher
    ..of the rat SVCT1 gene promoter, sites containing consensus sequences for the binding of the transcription factors Bach1 and HNF4 that are not present in equivalent locations in the human SVCT1 gene promoter...
  53. Matsumoto M, Kondo K, Shiraki T, Brydun A, Funayama R, Nakayama K, et al. Genomewide approaches for BACH1 target genes in mouse embryonic fibroblasts showed BACH1-Pparg pathway in adipogenesis. Genes Cells. 2016;21:553-67 pubmed publisher
    The transcription repressor BTB and CNC homology 1 (BACH1) represses genes involved in heme metabolism and oxidative stress response. BACH1 also suppresses the p53-dependent cellar senescence in primary mouse embryonic fibroblasts (MEFs)...
  54. Liu Y, Zheng Y. Bach1 siRNA attenuates bleomycin-induced pulmonary fibrosis by modulating oxidative stress in mice. Int J Mol Med. 2017;39:91-100 pubmed publisher
    Oxidative stress plays an essential role in inflammation and fibrosis. Bach1 is an important transcriptional repressor that acts by modulating oxidative stress and represents a potential target in the treatment of pulmonary fibrosis (PF)..
  55. Kishimoto D, Kirino Y, Tamura M, Takeno M, Kunishita Y, Takase Minegishi K, et al. Dysregulated heme oxygenase-1low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons. Arthritis Res Ther. 2018;20:64 pubmed publisher
    ..Effects of type I interferons on the expression levels of CD163, HO-1, BTB and CNC homology 1 (Bach1; a transcriptional HO-1 repressor), interleukin (IL)-6, and IL-10 by human M2-like Mϕ, which were differentiated ..
  56. Botto S, Totonchy J, Gustin J, Moses A. Kaposi Sarcoma Herpesvirus Induces HO-1 during De Novo Infection of Endothelial Cells via Viral miRNA-Dependent and -Independent Mechanisms. MBio. 2015;6:e00668 pubmed publisher
    ..A potential mechanism for this phenotype was provided by BACH1, a cellular HO-1 transcriptional repressor targeted by miR-K12-11...
  57. Raducu M, Fung E, Serres S, Infante P, Barberis A, Fischer R, et al. SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development. EMBO J. 2016;35:1400-16 pubmed publisher
    ..In summary, our findings reveal Fbxl17 as a novel regulator of Hh pathway and highlight the perturbation of the Fbxl17-Sufu axis in the pathogenesis of medulloblastoma. ..
  58. Zhou Y, Wu H, Zhao M, Chang C, Lu Q. The Bach Family of Transcription Factors: A Comprehensive Review. Clin Rev Allergy Immunol. 2016;50:345-56 pubmed publisher
    The transcription factors Bach1 and Bach2, which belong to a basic region-leucine zipper (bZip) family, repress target gene expression by forming heterodimers with small Maf proteins...
  59. Mohammadzadeh R, Saeid Harouyan M, Ale Taha S. Silencing of bach1 gene by small interfering RNA-mediation regulates invasive and expression level of miR-203, miR-145, matrix metalloproteinase-9, and CXCR4 receptor in MDA-MB-468 breast cancer cells. Tumour Biol. 2017;39:1010428317695925 pubmed publisher
    Recently experimental validation of the networks revealed bach1, a basic leucine zipper transcription factor, as the common regulator of several functional invasive genes...
  60. Igarashi K, Ota K, Nakame A. [Regulation of cellular senescence by Bach1]. Nihon Rinsho. 2009;67:1423-8 pubmed
    ..b>Bach1 inhibits expression of oxidative stress responsive genes by competing with Nrf2, the key activator of oxidative ..
  61. Itoh Nakadai A, Hikota R, Muto A, Kometani K, Watanabe Matsui M, Sato Y, et al. The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program. Nat Immunol. 2014;15:1171-80 pubmed publisher
    ..in the development of cells of the B lineage, commencing from the common lymphoid progenitor (CLP) stage, with Bach1 as an auxiliary...
  62. Li J, Shiraki T, Igarashi K. Transcription-independent role of Bach1 in mitosis through a nuclear exporter Crm1-dependent mechanism. FEBS Lett. 2012;586:448-54 pubmed publisher
    The transcriptional repressor Bach1 mediates various stress responses...
  63. Hu Y, Petit S, Ficarro S, Toomire K, Xie A, Lim E, et al. PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair. Cancer Discov. 2014;4:1430-47 pubmed publisher
    ..Thus, hyperfunctioning BRCA1 can elicit genomic abnormalities similar to those observed in the absence of certain BRCA1 functions. ..
  64. Zhang Z, Leir S, Harris A. Oxidative stress regulates CFTR gene expression in human airway epithelial cells through a distal antioxidant response element. Am J Respir Cell Mol Biol. 2015;52:387-96 pubmed publisher
    ..the -44-kb ARE is occupied by the repressor BTB and CNC homology 1, basic leucine zipper transcription factor (Bach1), and v-Maf avian musculoaponeurotic fibrosarcoma oncogene homolog K (MafK) heterodimers...
  65. Srinoun K, Nopparatana C, Wongchanchailert M, Fucharoen S. MiR-155 enhances phagocytic activity of ?-thalassemia/HbE monocytes via targeting of BACH1. Int J Hematol. 2017;106:638-647 pubmed publisher
    ..Increased miR-155 was associated with reductions in BTB and CNC Homology1 (BACH1) target gene expression and increased phagocytic activity of ?-thalassemia/HbE monocytes...
  66. Chang W, Thai P, Xu J, Yang D, Wu R, Chen C. Cigarette Smoke Regulates the Competitive Interactions between NRF2 and BACH1 for Heme Oxygenase-1 Induction. Int J Mol Sci. 2017;18: pubmed publisher
    ..In light of a pivotal role of NRF2 and BACH1 in response to oxidative stress and regulation of HO-1, we examined if smoke-induced HO-1 expression ..
  67. Luo X, Xiao L, Yang H, Zhang R, Jiang M, Ni J, et al. Homocysteine downregulates gene expression of heme oxygenase-1 in hepatocytes. Nutr Metab (Lond). 2014;11:55 pubmed publisher
    ..Instead, Hcy induced the expression of Bach1, a transcriptional repressor of HO-1...
  68. Kobayashi M, Kato H, Hada H, Itoh Nakadai A, Fujiwara T, Muto A, et al. Iron-heme-Bach1 axis is involved in erythroblast adaptation to iron deficiency. Haematologica. 2017;102:454-465 pubmed publisher
    ..The transcription factor Bach1 may be involved in their regulatory roles since it is deactivated by direct binding of heme...
  69. Zhang L, Zhang D, Zhao X, Sun W. Erythropoietin Rescues Primary Rat Cortical Neurons by Altering the Nrf2:Bach1 Ratio: Roles of Extracellular Signal-Regulated Kinase 1/2. Neurochem Res. 2017;: pubmed publisher
    ..Alteration of the nuclear factor erythroid 2-related factor (Nrf2)/BTB-to-CNC homology 1 (Bach1) ratio by Erk1/2 ameliorates the oxidative stress which occurs in human macrophages...
  70. Liu Y, Lu F, Kang L, Wang Z, Wang Y. Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium. BMC Pulm Med. 2017;17:63 pubmed publisher
    ..factor 2 (Nrf2)/[BTB (broad-complex, tramtrack and bric-a-brac) and CNC (cap'n'collar protein) homology 1, Bach1] determines the expression level of antioxidant factors, further regulating the function of oxidation/..
  71. Dohi Y, Ikura T, Hoshikawa Y, Katoh Y, Ota K, Nakanome A, et al. Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin. Nat Struct Mol Biol. 2008;15:1246-54 pubmed publisher
    ..Senescence is induced in response to genotoxic and oxidative stress. Here we show that the transcription factor Bach1 (BTB and CNC homology 1, basic leucine zipper transcription factor 1), which inhibits oxidative stress-inducible ..
  72. Kobayashi A, Yamagiwa H, Hoshino H, Muto A, Sato K, Morita M, et al. A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain. Mol Cell Biol. 2000;20:1733-46 pubmed
    ..The results provide a new perspective on the function of BTB/POZ domain factors and indicate that BTB/POZ domain-mediated oligomers of transcription factors may serve as combinatorial codes for gene expression. ..
  73. Suzuki H, Tashiro S, Sun J, Doi H, Satomi S, Igarashi K. Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene. J Biol Chem. 2003;278:49246-53 pubmed
    ..Although ho-1 is repressed by Bach1/small Maf heterodimers, it is activated by Nrf2/small Maf heterodimers, indicating that Bach1 and Nrf2 compete ..
  74. Sakamoto K, Iwasaki K, Sugiyama H, Tsuji Y. Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications. Mol Biol Cell. 2009;20:1606-17 pubmed publisher
    ..revealed that p300/CREB-binding protein (CBP) histone acetyltransferases and Nrf2 recruitment to the ARE and Bach1 release were blocked by the PI3K inhibitor LY294002, along with the partial inhibition of Nrf2 nuclear ..
  75. Aayadi H, Mittal S, Deshpande A, Gore M, Ghaskadbi S. Cytoprotective effect exerted by geraniin in HepG2 cells is through microRNA mediated regulation of BACH-1 and HO-1. BMB Rep. 2017;50:560-565 pubmed
    ..Up-regulation of HO-1 also confers protection to HepG2 cells from tertiary butyl hydroperoxide (TBH) induced cytotoxicity. [BMB Reports 2017; 50(11): 560-565]...
  76. Tahara T, Sun J, Igarashi K, Taketani S. Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells. Biochem Biophys Res Commun. 2004;324:77-85 pubmed
    The transcriptional factor Bach1 forms a heterodimer with small Maf family, and functions as a repressor of the Maf recognition element (MARE) in vivo...
  77. Lai T, Shieh J, Tsou C, Wu W. Gold nanoparticles induce heme oxygenase-1 expression through Nrf2 activation and Bach1 export in human vascular endothelial cells. Int J Nanomedicine. 2015;10:5925-39 pubmed publisher
    ..In response to the AuNP treatment, the cytosolic Nrf2 translocated to the nucleus, and, concomitantly, Bach1 exited the nucleus and its tyrosine phosphorylation increased...
  78. Liu D, Duan X, Dong D, Bai C, Li X, Sun G, et al. Activation of the Nrf2 pathway by inorganic arsenic in human hepatocytes and the role of transcriptional repressor Bach1. Oxid Med Cell Longev. 2013;2013:984546 pubmed publisher
    ..of Nrf2 protein in the nucleus, while exportting the transcriptional repressor BTB and CNC homology 1 (Bach1) from nucleus to cytoplasm, were also confirmed by western blot and immunofluorescence assay...
  79. Døssing K, Binderup T, Kaczkowski B, Jacobsen A, Rossing M, Winther O, et al. Down-Regulation of miR-129-5p and the let-7 Family in Neuroendocrine Tumors and Metastases Leads to Up-Regulation of Their Targets Egr1, G3bp1, Hmga2 and Bach1. Genes (Basel). 2014;6:1-21 pubmed publisher
    ..growth of carcinoid cell lines, and let-7 inhibition increased protein content of the transcription factor BACH1 and its targets MMP1 and HMGA2, all known to promote bone metastases...
  80. Goven D, Boutten A, Lecon Malas V, Boczkowski J, Bonay M. Prolonged cigarette smoke exposure decreases heme oxygenase-1 and alters Nrf2 and Bach1 expression in human macrophages: roles of the MAP kinases ERK(1/2) and JNK. FEBS Lett. 2009;583:3508-18 pubmed publisher
    ..ECH-associated protein 1 (Keap1)-BTB and CNC homology 1, basic leucine zipper transcription factor 1 (Bach1) pathway...
  81. Seifert M, Przekopowitz M, Taudien S, Lollies A, Ronge V, Drees B, et al. Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions. Proc Natl Acad Sci U S A. 2015;112:E546-55 pubmed publisher
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    ..1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer. ..
  83. Wang Y, Yang H, Wang H. Note of clarification of data in the paper entitled association between BRIP1 (BACH1) polymorphisms and breast cancer risk. Breast Cancer Res Treat. 2015;150:467-71 pubmed publisher
    With great interest, we read the recent article entitled "Association between BRIP1 (BACH1) polymorphisms and breast cancer risk: a meta-analysis" published online in Pabalan et al. (Breast Cancer Res Treat 137:553-558, 2013)...
  84. Gęgotek A, Niklinski J, Charkiewicz R, Bielawska K, Kozlowski M, Skrzydlewska E. Relationships between level of lipid peroxidation products and expression of Nrf2 and its activators/ inhibitors in non-small cell lung cancer tissue. Free Radic Biol Med. 2014;75 Suppl 1:S31 pubmed publisher
    ..The level of Nrf2 inhibitor - Bach1 was lower in all histological types of tumor, but in AC was the most reduced, what is correlated with the lowest ..
  85. Zou J, Ji D, Shen Y, Guan J, Zheng S. Association of Reduced Heme Oxygenase-1 with Decreased MicroRNA-196a2 Expression in Peripheral Blood Mononuclear Cells of Patients with Intestinal Behcet's Disease. Ann Clin Lab Sci. 2016;46:675-679 pubmed
    ..Expression levels of four miRNAs were studied using real-time PCR. The levels of mRNAs of ho-1, bach1, and CD14 were measured by qRT-PCR. Serum levels of cytokines were analyzed by ELISA...
  86. Kamola P, Kitson J, Turner G, Maratou K, Eriksson S, Panjwani A, et al. In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization. Nucleic Acids Res. 2015;43:8638-50 pubmed publisher
    ..high OTEs confirmation rate during screening of fully phosphorothioated (PS)-LNA gapmer ASOs designed against the BACH1 transcript...
  87. Pajares M, Jiménez Moreno N, García Yagüe A, Escoll M, De Ceballos M, Van Leuven F, et al. Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes. Autophagy. 2016;12:1902-1916 pubmed
    ..We screened the chromatin immunoprecipitation database ENCODE for 2 proteins, MAFK and BACH1, that bind the NFE2L2-regulated enhancer antioxidant response element (ARE)...
  88. Kurkewich J, Hansen J, Klopfenstein N, Zhang H, Wood C, Boucher A, et al. The miR-23a~27a~24-2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis. PLoS Genet. 2017;13:e1006887 pubmed publisher
    ..Early transcription factors that direct the commitment of MPPs to CLPs (Ikzf1, Runx1, Satb1, Bach1 and Bach2) are increased in the absence of mirn23a miRNAs as well as factors that commit the CLP to the B cell ..
  89. Ge Z, Zhou X, Gu Y, Han Q, Li J, Chen B, et al. Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia. Oncotarget. 2017;8:8022-8034 pubmed publisher
    ..Our data indicates that Ikaros regulates expression of the BCL6/BACH2 axis in B-ALL. High BCL6 and low BACH2 expression are associated with Ikaros dysregulation and have a potential effect on the development of B-ALL. ..
  90. Aletaha M, Mansoori B, Mohammadi A, Fazeli M, Baradaran B. Therapeutic effects of bach1 siRNA on human breast adenocarcinoma cell line. Biomed Pharmacother. 2017;88:34-42 pubmed publisher
    ..b>Bach1 plays a role in the development of the invasive phenotypes of cancer, cell division and apoptosis in tumor cells...
  91. Li R, Zhang L, Sun W. Erythropoietin rescues primary rat cortical neurons from pyroptosis and apoptosis via Erk1/2-Nrf2/Bach1 signal pathway. Brain Res Bull. 2017;130:236-244 pubmed publisher
    ..Nuclear factor erythroid 2-related factor (Nrf2)/BTB and CNC homology 1 (Bach1) ratio altering by Erk1/2 could ameliorate oxidative stress occurred in human macrophages...
  92. Zhu G, Liu F, Ouyang S, Zhou R, Jiang F, Zhang B, et al. BACH1 promotes the progression of human colorectal cancer through BACH1/CXCR4 pathway. Biochem Biophys Res Commun. 2018;499:120-127 pubmed publisher
    ..investigate clinical significance, biological functions and underlying mechanisms of BTB Domain and CNC Homolog 1(BACH1) deregulation in human colorectal cancer (CRC)...