Genomes and Genes
Gene Symbol: B4GALT6
Description: beta-1,4-galactosyltransferase 6
Alias: B4Gal-T6, beta4Gal-T6, beta-1,4-galactosyltransferase 6, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6, UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6, UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6, beta-1,4-GalTase 6, beta4GalT-VI
- Mayo L, Trauger S, Blain M, Nadeau M, Patel B, Alvarez J, et al. Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Nat Med. 2014;20:1147-56 pubmed publisher..Here we report that lactosylceramide (LacCer) synthesized by Î²-1,4-galactosyltransferase 6 (B4GALT6) is upregulated in the central nervous system (CNS) of mice during chronic experimental autoimmune ..
- Ruiz M, JovÃ© M, SchlÃ¼ter A, Casasnovas C, Villarroya F, Guilera C, et al. Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy. Hum Mol Genet. 2015;24:6861-76 pubmed publisher..such as glycosphingolipid and glycerophospholipid synthesis, governed by the Î²-1,4-galactosyltransferase (B4GALT6), the phospholipase 2Î³ (PLA2G4C) and the choline/ethanolamine phosphotransferase (CEPT1) enzymes...
- Landers J, Melki J, Meininger V, Glass J, van den Berg L, van Es M, et al. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2009;106:9004-9 pubmed publisher..These findings support the view that genetic factors modify phenotypes in this disease and that cellular motor proteins are determinants of motor neuron viability. ..