Gene Symbol: B4GALT6
Description: beta-1,4-galactosyltransferase 6
Alias: B4Gal-T6, beta4Gal-T6, beta-1,4-galactosyltransferase 6, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6, UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6, UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6, beta-1,4-GalTase 6, beta4GalT-VI
Species: human
Products:     B4GALT6

Top Publications

  1. Goetstouwers T, Van Poucke M, Coddens A, Nguyen V, Melkebeek V, Deforce D, et al. Variation in 12 porcine genes involved in the carbohydrate moiety assembly of glycosphingolipids does not account for differential binding of F4 Escherichia coli and their fimbriae. BMC Genet. 2014;15:103 pubmed publisher
    ..e. ARSA, B4GALT6, GAL3ST1, GALC, GBA, GLA, GLB1, GLB1L, NEU1, NEU2, UGCG, UGT8) could account for differential binding of F4 ETEC ..
  2. Wang H, Zhang W, Yu J, Wu C, Gao Q, Li X, et al. Genetic screening and multipotency in rhesus monkey haploid neural progenitor cells. Development. 2018;145: pubmed publisher
    ..Using CRISPR/Cas9 editing, we confirmed that B4GALT6, from the candidate gene list, is a resistance gene of A803467 (a tetrodotoxin-like toxicant)...
  3. Xu Y, Qi X, Hu M, Lin R, Hou Y, Wang Z, et al. Transcriptome Analysis of Adipose Tissue Indicates That the cAMP Signaling Pathway Affects the Feed Efficiency of Pigs. Genes (Basel). 2018;9: pubmed publisher
    ..In high-FE pigs, the key genes involved in the lipid biosynthetic process (ELOVL7 and B4GALT6), fatty acid oxidation (ABCD2 and NR4A3), and lipid homeostasis (C1QTNF3 and ABCB4..
  4. Huang H, Zhu Y, Eliot M, Knopik V, McGeary J, Carskadon M, et al. Combining Human Epigenetics and Sleep Studies in Caenorhabditis elegans: A Cross-Species Approach for Finding Conserved Genes Regulating Sleep. Sleep. 2017;40: pubmed publisher
    ..Loss of five additional genes alters developmentally timed C. elegans sleep (B4GALT6/bre-4, DOCK180/ced-5, GNB2L1/rack-1, PTPRN2/ida-1, ZFYVE28/lst-2)...
  5. Gerovska D, Araúzo Bravo M. Does mouse embryo primordial germ cell activation start before implantation as suggested by single-cell transcriptomics dynamics?. Mol Hum Reprod. 2016;22:208-25 pubmed publisher
    ..Among the transitory E3.5 PE markers (Dnmt3l, Dusp4, Cpne8, Akap13, Dcaf12l1, Aaed1, B4galt6, BC100530, Rnpc3, Tfpi, Lgalsl, Ckap4 and Fbxl20), several (Dusp4, Akap13, Cpn8, Dcaf12l1 and Tfpi) are related ..
  6. Lo N, Shaper J, Pevsner J, Shaper N. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. Glycobiology. 1998;8:517-26 pubmed
  7. Takizawa M, Nomura T, Wakisaka E, Yoshizuka N, Aoki J, Arai H, et al. cDNA cloning and expression of human lactosylceramide synthase. Biochim Biophys Acta. 1999;1438:301-4 pubmed
    ..2% identity with rat lactosylceramide synthase. Northern blotting analysis revealed that lactosylceramide synthase mRNA was expressed in various tissues, with the highest level in brain and adrenal gland. ..
  8. Amado M, Almeida R, Schwientek T, Clausen H. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. Biochim Biophys Acta. 1999;1473:35-53 pubmed
  9. Fan Y, Yu L, Tu Q, Gong R, Jiang Y, Zhang Q, et al. Molecular cloning, genomic organization, and mapping of beta 4GalT-VIb, a brain abundant member of beta 4-galactosyltransferase gene family, to human chromosome 18q12.1. DNA Seq. 2002;13:1-8 pubmed
    ..In addition, the most conserved motif composed of 41 residues, LXYX3FGGVSXL(T/S)X2 QFX2INGFPNX(Y/F)WGWGGEDDDX2NR, was defined according to 17 sequences of beta 4GalTs from seven different organisms for the first time. ..

More Information


  1. Mayo L, Trauger S, Blain M, Nadeau M, Patel B, Alvarez J, et al. Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Nat Med. 2014;20:1147-56 pubmed publisher
    ..Here we report that lactosylceramide (LacCer) synthesized by β-1,4-galactosyltransferase 6 (B4GALT6) is upregulated in the central nervous system (CNS) of mice during chronic experimental autoimmune ..
  2. Ruiz M, Jové M, Schlüter A, Casasnovas C, Villarroya F, Guilera C, et al. Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy. Hum Mol Genet. 2015;24:6861-76 pubmed publisher
    ..such as glycosphingolipid and glycerophospholipid synthesis, governed by the β-1,4-galactosyltransferase (B4GALT6), the phospholipase 2γ (PLA2G4C) and the choline/ethanolamine phosphotransferase (CEPT1) enzymes...
  3. Landers J, Melki J, Meininger V, Glass J, van den Berg L, van Es M, et al. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2009;106:9004-9 pubmed publisher
    ..These findings support the view that genetic factors modify phenotypes in this disease and that cellular motor proteins are determinants of motor neuron viability. ..