Gene Symbol: B4GALT5
Description: beta-1,4-galactosyltransferase 5
Alias: B4Gal-T5, BETA4-GALT-IV, beta4Gal-T5, beta4GalT-V, gt-V, beta-1,4-galactosyltransferase 5, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5, UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 5, beta-1,4-GalT II, beta-1,4-GalT IV, beta-1,4-GalTase 5, beta-1.4-galactosyltransferase V, beta4-GalT IV
Species: human
Products:     B4GALT5

Top Publications

  1. Amado M, Almeida R, Schwientek T, Clausen H. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. Biochim Biophys Acta. 1999;1473:35-53 pubmed
  2. Xu S, Zhang S, Chen C, Yan J, Cai M, Zhu X, et al. Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line. J Exp Clin Cancer Res. 2002;21:409-14 pubmed
    ..05) respectively compared with the mock transfectant. This indicates that beta-1,4-GalT V was involved in the malignant phenotype of astrocytoma cells, possibly causing the high galactosylation on the cell surface. ..
  3. Wei Y, Zhou F, Ge Y, Chen H, Cui C, Li Q, et al. Beta1,4-galactosyltransferase V regulates self-renewal of glioma-initiating cell. Biochem Biophys Res Commun. 2010;396:602-7 pubmed publisher
  4. Wang D, Zhu Z, Jiang H, Zhu J, Cong W, Wen B, et al. Multiple genes identified as targets for 20q13.12-13.33 gain contributing to unfavorable clinical outcomes in patients with hepatocellular carcinoma. Hepatol Int. 2015;9:438-46 pubmed publisher
    ..High expression (greater than median) for 5 of the 19 genes, DDX27, B4GALT5, RNF114, ZFP64 and PFDN4, correlated significantly with vascular invasion, and high RNF114 expression also with ..
  5. Li S, Zhu C, Wang Y, Xie X, Xiao L, Zhang Z, et al. Downregulation of β1,4-galactosyltransferase 5 improves insulin resistance by promoting adipocyte commitment and reducing inflammation. Cell Death Dis. 2018;9:196 pubmed publisher
    ..We showed that the expression of β1, 4-galactosyltransferase 5 (B4GalT5) was positively correlated with diabetes and obesity...
  6. Parker B, Thaysen Andersen M, Fazakerley D, Holliday M, Packer N, James D. Terminal Galactosylation and Sialylation Switching on Membrane Glycoproteins upon TNF-Alpha-Induced Insulin Resistance in Adipocytes. Mol Cell Proteomics. 2016;15:141-53 pubmed publisher
    ..adipocytes correlated with the regulation of specific glycosyltransferases, including the up-regulation of B4GalT5 and Ggta1 galactosyltransferases and down-regulation of ST3Gal6 sialyltransferase...
  7. Sato T, Furukawa K, Bakker H, van den Eijnden D, Van Die I. Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase. Proc Natl Acad Sci U S A. 1998;95:472-7 pubmed
    ..Northern blot analysis of 24 human tissues showed that they all express the beta-1,4-GalT II transcript, although the levels varied. These results indicate that human cells contain another beta-1,4-GalT. ..
  8. Sato T, Aoki N, Matsuda T, Furukawa K. Differential effect of alpha-lactalbumin on beta-1,4-galactosyltransferase IV activities. Biochem Biophys Res Commun. 1998;244:637-41 pubmed
    ..These results indicate that beta-1,4-GalT IV can interact with alpha-lactalbumin but has no lactose synthetase activity. ..
  9. Lo N, Shaper J, Pevsner J, Shaper N. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. Glycobiology. 1998;8:517-26 pubmed

More Information


  1. Jiang J, Chen X, Shen J, Wei Y, Wu T, Yang Y, et al. Beta1,4-galactosyltransferase V functions as a positive growth regulator in glioma. J Biol Chem. 2006;281:9482-9 pubmed
    ..Taken together, our results suggest that GalT V functioned as a novel glioma growth activator and might represent a novel target in glioma therapy. ..
  2. Sato T, Furukawa K. Transcriptional regulation of the human beta-1,4-galactosyltransferase V gene in cancer cells: essential role of transcription factor Sp1. J Biol Chem. 2004;279:39574-83 pubmed
    ..These results indicate that Sp1 plays an essential role in the transcriptional activity of the beta-1,4-GalT V gene in cancer cells. ..
  3. Sato T, Furukawa K. Sequential action of Ets-1 and Sp1 in the activation of the human beta-1,4-galactosyltransferase V gene involved in abnormal glycosylation characteristic of cancer cells. J Biol Chem. 2007;282:27702-12 pubmed
    ..These results indicate that Ets-1 enhances expression of the beta-1,4-GalT V gene through activation of the Sp1 gene in cancer cells. ..
  4. Kitayama K, Hayashida Y, Nishida K, Akama T. Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans. J Biol Chem. 2007;282:30085-96 pubmed
  5. Sato T, Furukawa K. [Regulation of human ?-1,4-galactosyltransferase V gene expression in cancer cells]. Yakugaku Zasshi. 2012;132:691-7 pubmed
    ..Also, a perspective on applications of the manipulation of transcription factor genes to cancer therapy will be discussed. ..
  6. Zhou H, Ma H, Wei W, Ji D, Song X, Sun J, et al. B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1. Cell Death Dis. 2013;4:e654 pubmed publisher
    ..The results revealed that B4GALT1 and B4GALT5 were highly expressed in four MDR cells and patients, altered levels of B4GALT1 and B4GALT5 were responsible for ..