Gene Symbol: B4GALT4
Description: beta-1,4-galactosyltransferase 4
Alias: B4Gal-T4, beta4Gal-T4, beta-1,4-galactosyltransferase 4, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4, UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 4, UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4, beta-1,4-GalTase 4, beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 4
Bydlinski N, Maresch D, Schmieder V, Klanert G, Strasser R, Borth N. The contributions of individual galactosyltransferases to protein specific N-glycan processing in Chinese Hamster Ovary cells. J Biotechnol. 2018;282:101-110 pubmed publisher
..of this key-player as well as of the other isoenzymes involved in N-glycosylation, B4GALT2, B4GALT3 and B4GALT4, have not been studied in-depth...
Amado M, Almeida R, Schwientek T, Clausen H. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. Biochim Biophys Acta. 1999;1473:35-53 pubmed
Sugiyama A, Fukushima N, Sato T. Transcriptional Mechanism of the ?4-Galactosyltransferase 4 Gene in SW480 Human Colon Cancer Cell Line. Biol Pharm Bull. 2017;40:733-737 pubmed publisher
..The present study suggests that the expression of the ?4GalT4 gene is controlled by Sp1, and Sp1 plays a key role in the activation of the ?4GalT4 gene in colon cancer cells. ..
Lo N, Shaper J, Pevsner J, Shaper N. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. Glycobiology. 1998;8:517-26 pubmed
Schwientek T, Almeida R, Levery S, Holmes E, Bennett E, Clausen H. Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis. J Biol Chem. 1998;273:29331-40 pubmed
..beta4Gal-T4 represents a new member of the beta4-galactosyltransferase family. Its kinetic parameters suggest unique functions in the synthesis of neolactoseries glycosphingolipids. ..
Guo S, Sato T, Shirane K, Furukawa K. Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells. Glycobiology. 2001;11:813-20 pubmed
..These results indicate that beta-1,4-GalTs II, III, IV, V, and VI are involved in the N-linked oligosaccharide biosynthesis cooperatively but not in a redundant manner with beta-1,4-GalT I within cells. ..
Irungu J, Go E, Zhang Y, Dalpathado D, Liao H, Haynes B, et al
. Comparison of HPLC/ESI-FTICR MS versus MALDI-TOF/TOF MS for glycopeptide analysis of a highly glycosylated HIV envelope glycoprotein. J Am Soc Mass Spectrom. 2008;19:1209-20 pubmed publisher
..The information in this study contributes to the field of mass spectrometry by demonstrating the strengths and limitations of two widely used MS platforms in glycoprotein analysis. ..
Fan Y, Yu L, Zhang Q, Jiang Y, Dai F, Chen C, et al
. Cloning and characterization of a novel member of human beta-1,4-galactosyltransferase gene family. Sci China C Life Sci. 1999;42:337-45 pubmed publisher
..Its mRNA is present in different degrees in 16 tissues examined. Southern analysis of human genomic DNA revealed its locus on chromosome 3. ..