B4GALT2

Summary

Gene Symbol: B4GALT2
Description: beta-1,4-galactosyltransferase 2
Alias: B4Gal-T2, B4Gal-T3, beta4Gal-T2, beta-1,4-galactosyltransferase 2, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2, UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 2, UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 2, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2, beta-1,4-GalTase 2, beta-4-GalT2, beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 2
Species: human
Products:     B4GALT2

Top Publications

  1. Bydlinski N, Maresch D, Schmieder V, Klanert G, Strasser R, Borth N. The contributions of individual galactosyltransferases to protein specific N-glycan processing in Chinese Hamster Ovary cells. J Biotechnol. 2018;282:101-110 pubmed publisher
    ..the exact contributions of this key-player as well as of the other isoenzymes involved in N-glycosylation, B4GALT2, B4GALT3 and B4GALT4, have not been studied in-depth...
  2. Amado M, Almeida R, Schwientek T, Clausen H. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. Biochim Biophys Acta. 1999;1473:35-53 pubmed
  3. Ben Mahmud B, Mann G, Datti A, Orlacchio A, Kohner E, Chibber R. Tumor necrosis factor-alpha in diabetic plasma increases the activity of core 2 GlcNAc-T and adherence of human leukocytes to retinal endothelial cells: significance of core 2 GlcNAc-T in diabetic retinopathy. Diabetes. 2004;53:2968-76 pubmed
  4. Brockhausen I, Dowler T, Paulsen H. Site directed processing: role of amino acid sequences and glycosylation of acceptor glycopeptides in the assembly of extended mucin type O-glycan core 2. Biochim Biophys Acta. 2009;1790:1244-57 pubmed publisher
    ..Knowledge of site directed processing enhances our understanding of the control of O-glycosylation in normal cells and in disease. ..
  5. Lo N, Shaper J, Pevsner J, Shaper N. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. Glycobiology. 1998;8:517-26 pubmed
  6. Guo S, Sato T, Shirane K, Furukawa K. Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells. Glycobiology. 2001;11:813-20 pubmed
    ..These results indicate that beta-1,4-GalTs II, III, IV, V, and VI are involved in the N-linked oligosaccharide biosynthesis cooperatively but not in a redundant manner with beta-1,4-GalT I within cells. ..
  7. Irungu J, Go E, Zhang Y, Dalpathado D, Liao H, Haynes B, et al. Comparison of HPLC/ESI-FTICR MS versus MALDI-TOF/TOF MS for glycopeptide analysis of a highly glycosylated HIV envelope glycoprotein. J Am Soc Mass Spectrom. 2008;19:1209-20 pubmed publisher
    ..The information in this study contributes to the field of mass spectrometry by demonstrating the strengths and limitations of two widely used MS platforms in glycoprotein analysis. ..
  8. Venkitachalam S, Revoredo L, Varadan V, Fecteau R, Ravi L, Lutterbaugh J, et al. Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer. Sci Rep. 2016;6:23642 pubmed publisher
    ..In particular, we observed an enrichment of mutations in genes (B3GNT2, B4GALT2, ST6GALNAC2) involved in the biosynthesis of N- and Cores 1-3 O-linked glycans in the colon, accounting for ~16% ..
  9. Almeida R, Amado M, David L, Levery S, Holmes E, Merkx G, et al. A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3. J Biol Chem. 1997;272:31979-91 pubmed
    ..The existence of multiple beta4-galactosyltransferases with the same or overlapping functions may be relevant for interpretation of biological functions previously assigned to beta4Gal-T1. ..

More Information

Publications12

  1. Sasaki N, Manya H, Okubo R, Kobayashi K, Ishida H, Toda T, et al. beta4GalT-II is a key regulator of glycosylation of the proteins involved in neuronal development. Biochem Biophys Res Commun. 2005;333:131-7 pubmed
    ..Thus, these results suggest that among human beta4GalTs, beta4GalT-II is a major regulator of the synthesis of glycans involved in neuronal development. ..
  2. Jiang J, Zhou J, Wei Y, Shen J, Liu D, Chen X, et al. beta4GalT-II increases cisplatin-induced apoptosis in HeLa cells depending on its Golgi localization. Biochem Biophys Res Commun. 2007;358:41-6 pubmed
  3. Zhou J, Wei Y, Liu D, Ge X, Zhou F, Jiang X, et al. Identification of beta1,4GalT II as a target gene of p53-mediated HeLa cell apoptosis. J Biochem. 2008;143:547-54 pubmed publisher
    ..Collectively, these results suggested that beta1,4GalT II might serve as a target gene of p53 transcription factor during adriamycin-induced HeLa cell apoptosis, which elucidated a new mechanism of p53-mediated cell apoptosis. ..