B3GNT3

Summary

Gene Symbol: B3GNT3
Description: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Alias: B3GAL-T8, B3GN-T3, B3GNT-3, HP10328, TMEM3, beta3Gn-T3, N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3, UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8, UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 8, beta-1,3-GalTase 8, beta-1,3-Gn-T3, beta-1,3-N-acetylglucosaminyltransferase bGnT-3, beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase, beta-3-Gx-T8, beta3GalT8, core 1 extending beta-1,3-N-acetylglucosaminyltransferase, core1-beta3GlcNAcT, transmembrane protein 3
Species: human
Products:     B3GNT3

Top Publications

  1. Gan C, Sam K, Yee P, Zainal N, Lee B, Abdul Rahman Z, et al. IFITM3 knockdown reduces the expression of CCND1 and CDK4 and suppresses the growth of oral squamous cell carcinoma cells. Cell Oncol (Dordr). 2019;: pubmed publisher
    ..In this study, we examined the expression and functional role of interferon transmembrane protein 3 (IFITM3) in OSCC development...
  2. Veerman K, Tardiveau C, Martins F, Coudert J, Girard J. Single-Cell Analysis Reveals Heterogeneity of High Endothelial Venules and Different Regulation of Genes Controlling Lymphocyte Entry to Lymph Nodes. Cell Rep. 2019;26:3116-3131.e5 pubmed publisher
    ..Most importantly, we uncover differences in the regulation of genes controlling lymphocyte trafficking, Glycam1, Fut7, Gcnt1, Chst4, B3gnt3, and Ccl21a, that have implications for HEV function and regulation in health and disease.
  3. Du S, Jiang Y, Xu W, Bai J, Tian M, Wang M, et al. Construction, expression and antiviral activity analysis of recombinant adenovirus expressing human IFITM3 in vitro. Int J Biol Macromol. 2019;131:925-932 pubmed publisher
    Interferon-inducible transmembrane protein 3 (IFITM3) inhibits the replication of multiple pathogenic viruses by blocking their entry. In this study, we constructed a shuttle plasmid, harboring human IFITM3...
  4. Campbell R, Schwertz H, Hottz E, Rowley J, Manne B, Washington A, et al. Human megakaryocytes possess intrinsic anti-viral immunity through regulated induction of IFITM3. Blood. 2019;: pubmed publisher
    ..pharmacological, and genetic approaches, we examined the regulation and function of interferon induced transmembrane protein 3 (IFITM3), an anti-viral immune effector gene not previously studied in human platelets and MKs...
  5. Doyle T, Moncorgé O, Bonaventure B, Pollpeter D, Lussignol M, Tauziet M, et al. The interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry. Nat Microbiol. 2018;3:1369-1376 pubmed publisher
    ..influenza A virus (IAV)4 are the myxovirus resistance 1 GTPase5 and IFN-induced transmembrane protein 3 (refs 6,7)...
  6. Liang Y, Li E, Min J, Gong C, Gao J, Ai J, et al. miR‑29a suppresses the growth and metastasis of hepatocellular carcinoma through IFITM3. Oncol Rep. 2018;40:3261-3272 pubmed publisher
    ..Thus, the present study indicated that miR‑29a and IFITM3 play critical roles in the development and progression of HCC, revealing that miR‑29a and IFITM3 may be novel potential therapeutic targets for patients with HCC. ..
  7. Bauer D, Pai S. Getting Past HSC Security: Cyclosporine H Gives Lentiviruses an Entry Pass. Cell Stem Cell. 2018;23:775-776 pubmed publisher
    ..stem cells (HSCs) by using cyclosporine H to relieve viral entry restriction by interferon-induced transmembrane protein 3 (IFITM3)...
  8. Appourchaux R, Delpeuch M, Zhong L, Burlaud Gaillard J, Tartour K, Savidis G, et al. Functional Mapping of Regions Involved in the Negative Imprinting of Virion Particle Infectivity and in Target Cell Protection by Interferon-Induced Transmembrane Protein 3 against HIV-1. J Virol. 2019;93: pubmed publisher
    ..These findings thus advance our comprehension of how this class of broad antiviral restriction factors acts. ..
  9. Barkeer S, Chugh S, Karmakar S, Kaushik G, Rauth S, Rachagani S, et al. Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells. BMC Cancer. 2018;18:1157 pubmed publisher
    ..Co-expression of GALNT3 and B3GNT3 with CD44v6 was assessed in progression stages of KrasG12D; Pdx-1-Cre (KC) and KrasG12D; p53<..

More Information

Publications55

  1. Petrillo C, Thorne L, Unali G, Schiroli G, Giordano A, Piras F, et al. Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells. Cell Stem Cell. 2018;23:820-832.e9 pubmed publisher
    ..enhances gene transfer and editing in human long-term repopulating HSCs by inhibiting interferon-induced transmembrane protein 3 (IFITM3), which potently restricts VSV glycoprotein-mediated vector entry...
  2. Jiang L, Xia T, Hu Y, Sun M, Yan S, Lei C, et al. IFITM3 inhibits virus-triggered induction of type I interferon by mediating autophagosome-dependent degradation of IRF3. Cell Mol Immunol. 2018;15:858-867 pubmed publisher
    Interferon-induced transmembrane protein 3 (IFITM3) is a restriction factor that can be induced by viral infection and interferons (IFNs)...
  3. Yamada S, Itoh N, Nagai T, Nakai T, Ibi D, Nakajima A, et al. Innate immune activation of astrocytes impairs neurodevelopment via upregulation of follistatin-like 1 and interferon-induced transmembrane protein 3. J Neuroinflammation. 2018;15:295 pubmed publisher
    ..The extracellular level of Fstl1 is regulated by Ifitm3 in astrocytes, which could be involved in polyI:C-induced neurodevelopmental impairment. ..
  4. Hu X, Lu H, Cao S, Deng Y, Li Q, Wan Q, et al. Stem cells derived from human first-trimester umbilical cord have the potential to differentiate into oocyte-like cells in vitro. Int J Mol Med. 2015;35:1219-29 pubmed publisher
    ..factor AP-2 gamma (Tfap2C), VASA, STELLA, deleted in azoospermia-like (DAZL) and interferon-induced transmembrane protein 3 (IFITM3)...
  5. Lopez Gonzalez M, Meza Sánchez D, García Cordero J, Bustos Arriaga J, Velez Del Valle C, Marsch Moreno M, et al. Human keratinocyte cultures (HaCaT) can be infected by DENV, triggering innate immune responses that include IFNλ and LL37. Immunobiology. 2018;223:608-617 pubmed publisher
  6. Xuan Y, Wang L, Li W, Zi H, Guo Y, Yan W, et al. IFITM3 rs12252 T>C polymorphism is associated with the risk of severe influenza: a meta-analysis. Epidemiol Infect. 2015;143:2975-84 pubmed publisher
    The interferon-inducible transmembrane protein 3 (IFITM3), as one of the key genes involved in the interferon pathway, is critical for defending the host against influenza virus, and the rs12252 T>C variant in IFITM3 might be ..
  7. Benfield C, Smith S, Wright E, Wash R, Ferrara F, Temperton N, et al. Bat and pig IFN-induced transmembrane protein 3 restrict cell entry by influenza virus and lyssaviruses. J Gen Virol. 2015;96:991-1005 pubmed publisher
    IFN-induced transmembrane protein 3 (IFITM3) is a restriction factor that blocks cytosolic entry of numerous viruses that utilize acidic endosomal entry pathways...
  8. Zhang Y, Makvandi Nejad S, Qin L, Zhao Y, Zhang T, Wang L, et al. Interferon-induced transmembrane protein-3 rs12252-C is associated with rapid progression of acute HIV-1 infection in Chinese MSM cohort. AIDS. 2015;29:889-94 pubmed publisher
    ..A novel association between IFITM3 gene polymorphism and rapid disease progression is reported in an acute HIV-1-infected MSM cohort in China. ..
  9. Ibi D, Nagai T, Nakajima A, Mizoguchi H, Kawase T, Tsuboi D, et al. Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice. Glia. 2013;61:679-93 pubmed publisher
    Interferon-induced transmembrane protein 3 (IFITM3) ıplays a crucial role in the antiviral responses of Type I interferons (IFNs)...
  10. Nakajima A, Ibi D, Nagai T, Yamada S, Nabeshima T, Yamada K. Induction of interferon-induced transmembrane protein 3 gene expression by lipopolysaccharide in astrocytes. Eur J Pharmacol. 2014;745:166-75 pubmed publisher
    ..We have recently demonstrated the role of interferon-induced transmembrane protein 3 (IFITM3) in long-lasting neuronal impairments in mice following neonatal immune challenge by injections ..
  11. Prabhu S, Chakraborty T, Kumar N, Banerjee I. Association between IFITM3 rs12252 polymorphism and influenza susceptibility and severity: A meta-analysis. Gene. 2018;674:70-79 pubmed publisher
    ..Recent studies suggested, the rs12252 T?>?C polymorphism in the interferon-inducible transmembrane protein 3 (IFITM3) gene might be associated with susceptibility to severe influenza...
  12. Hu J, Wang S, Zhao Y, Guo Q, Zhang D, Chen J, et al. Mechanism and biological significance of the overexpression of IFITM3 in gastric cancer. Oncol Rep. 2014;32:2648-56 pubmed publisher
    Interferon‑induced transmembrane protein 3 (IFITM3) has been recently identified as a potential molecular marker...
  13. Yang X, Tan B, Zhou X, Xue J, Zhang X, Wang P, et al. Interferon-Inducible Transmembrane Protein 3 Genetic Variant rs12252 and Influenza Susceptibility and Severity: A Meta-Analysis. PLoS ONE. 2015;10:e0124985 pubmed publisher
    ..The rs12252-C allele causes a 23.7% higher chance of infection and also constitutes a risk factor for more severe influenza. ..
  14. Debette S, Bis J, Fornage M, Schmidt H, Ikram M, Sigurdsson S, et al. Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium. Stroke. 2010;41:210-7 pubmed publisher
    ..in intron 3 of MACRO domain containing 2 gene and in the downstream region of fibronectin leucine-rich transmembrane protein 3 gene. Each copy of the minor allele was associated with lower risk of MRI infarcts (odds ratio, 0...
  15. Kühnl A, Musiol A, Heitzig N, Johnson D, Ehrhardt C, Grewal T, et al. Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus. MBio. 2018;9: pubmed publisher
    ..The antiviral host interferon (IFN) response includes the upregulation of interferon-induced transmembrane protein 3 (IFITM3), which inhibits the release of the viral content into the cytosol...
  16. McMichael T, Zhang Y, Kenney A, Zhang L, Zani A, Lu M, et al. IFITM3 Restricts Human Metapneumovirus Infection. J Infect Dis. 2018;218:1582-1591 pubmed publisher
    ..We found that the interferon-induced transmembrane protein 3 (IFITM3) inhibits hMPV infection to an extent similar to endocytosis-inhibiting drugs, and an IFITM3 ..
  17. Cherian R, Jin C, Liu J, Karlsson N, Holgersson J. A Panel of Recombinant Mucins Carrying a Repertoire of Sialylated O-Glycans Based on Different Core Chains for Studies of Glycan Binding Proteins. Biomolecules. 2015;5:1810-31 pubmed publisher
    ..glycosyltransferases to synthesize core 2 (GCNT1), core 3 (B3GNT6), core 4 (GCNT1 and B3GNT6), or extended core 1 (B3GNT3) chains with or without the type 1 chain-encoding enzyme B3GALT5 and ST6GAL1...
  18. Li C, Lim S, Chung E, Kim Y, Park A, Yao J, et al. Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1. Cancer Cell. 2018;33:187-201.e10 pubmed publisher
    ..receptor programmed cell death protein 1 (PD-1) interaction, requiring β-1,3-N-acetylglucosaminyl transferase (B3GNT3) expression in triple-negative breast cancer...
  19. Stankovic N, Hoppmann N, Teodorczyk M, Kim E, Bros M, Giese A, et al. No role of IFITM3 in brain tumor formation in vivo. Oncotarget. 2016;7:86388-86405 pubmed publisher
    ..of irradiated, patient-derived BTPCs revealed a significant upregulation of the interferon-inducible transmembrane protein 3 (IFITM3), suggesting the protein as a factor mediating radio resistance...
  20. Shen C, Li Y, Yin Q, Jiao W, Li Q, Xiao J, et al. Identification of differentially expressed transcripts targeted by the knockdown of endogenous IFITM3. Mol Med Rep. 2016;14:4367-4373 pubmed publisher
    ..These findings may lead to an improved understanding of the biological functions of IFITM3. ..
  21. Xu Yang Z, Pei Yu B, Chuan Tao Y, Wei Y, Hong Wei M, Kang T, et al. Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome. Front Immunol. 2016;7:535 pubmed publisher
    ..Taken together, we conclude that IFITM3, negatively regulated by NRIR, inhibits HTNV infection, and its SNP rs12252 correlates with the plasma HTNV load and the disease severity of patients with HFRS. ..
  22. Korsensky L, Ron D. Regulation of FGF signaling: Recent insights from studying positive and negative modulators. Semin Cell Dev Biol. 2016;53:101-14 pubmed publisher
    ..the FGF signal exemplified by recently identified protein modulators anosmin-1, fibronectin-leucine-rich transmembrane protein 3 (FLRT3) and similar expression to FGF (Sef)...
  23. Blyth G, Chan W, Webster R, Magor K. Duck Interferon-Inducible Transmembrane Protein 3 Mediates Restriction of Influenza Viruses. J Virol. 2016;90:103-16 pubmed publisher
    ..Thus, despite long coevolution of virus and host effectors in the natural host, influenza virus evasion of IFITM3 restriction in ducks is not apparent. ..
  24. Wu R, Wu L, Li K, Li E, Feng Q, Zhang J. [Interferon-induced transmembrane protein 3 knock-down inhibits proliferation and invasion of hepatocellular carcinoma HepG2 cells in vitro]. Nan Fang Yi Ke Da Xue Xue Bao. 2016;36:244-9 pubmed
    To investigate the abnormal expression of interferon-induced transmembrane protein 3 (IFITM3) in hepatocellular carcinoma (HCC) and the effect of IFITM3 knock-down on the biological behaviors of hepatocellular carcinoma HepG2 cells...
  25. Wang Z, Zhang A, Wan Y, Liu X, Qiu C, Xi X, et al. Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection. Proc Natl Acad Sci U S A. 2014;111:769-74 pubmed publisher
    ..Together with rs12252 sequencing, early monitoring of plasma cytokines is thus of prognostic value for the treatment and management of severe influenza pneumonia. ..
  26. Li C, Du S, Tian M, Wang Y, Bai J, Tan P, et al. The Host Restriction Factor Interferon-Inducible Transmembrane Protein 3 Inhibits Vaccinia Virus Infection. Front Immunol. 2018;9:228 pubmed publisher
    ..Here, we sought to investigate the antiviral activities and mechanisms of interferon-inducible transmembrane protein 3 (IFITM3) protein against poxvirus infection...
  27. Stacey M, Clare S, Clement M, Marsden M, Abdul Karim J, Kane L, et al. The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis. J Clin Invest. 2017;127:1463-1474 pubmed publisher
    The antiviral restriction factor IFN-induced transmembrane protein 3 (IFITM3) inhibits cell entry of a number of viruses, and genetic diversity within IFITM3 determines susceptibility to viral disease in humans...
  28. Kandathil A, Graw F, Quinn J, Hwang H, Torbenson M, Perelson A, et al. Use of laser capture microdissection to map hepatitis C virus-positive hepatocytes in human liver. Gastroenterology. 2013;145:1404-13.e1-10 pubmed publisher
    ..HCV vRNA and interferon-induced transmembrane protein 3 (IFITM3) messenger RNA (the transcript of an interferon-stimulated gene) were measured in the same ..
  29. Chesarino N, McMichael T, Yount J. E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3. PLoS Pathog. 2015;11:e1005095 pubmed publisher
    Interferon (IFN)-induced transmembrane protein 3 (IFITM3) is a cell-intrinsic factor that limits influenza virus infections...
  30. Gao L, Zhang H, Zhang B, Zhu J, Chen C, Liu W. B3GNT3 overexpression is associated with unfavourable survival in non-small cell lung cancer. J Clin Pathol. 2018;71:642-647 pubmed publisher
    The aim of this study was to evaluate the expression of beta-1,3-N-acetylglucosaminyltransferase-3 (B3GNT3) in non-small cell lung cancer (NSCLC) patients and to investigate the relevance of B3GNT3 expression in tumour prognosis...
  31. Zhang D, Wang H, He H, Niu H, Li Y. Interferon induced transmembrane protein 3 regulates the growth and invasion of human lung adenocarcinoma. Thorac Cancer. 2017;8:337-343 pubmed publisher
    Interferon induced transmembrane protein 3 (IFITM3) plays an important role in the tumorigenesis and progression of multiple cancers. This study investigated the expression and function of IFITM3 in human lung adenocarcinoma...
  32. Poddar S, Hyde J, Gorman M, Farzan M, Diamond M. The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses. J Virol. 2016;90:8780-94 pubmed publisher
    ..The interferon-induced transmembrane protein 3 (IFITM3) inhibits infection of multiple families of viruses in cell culture...
  33. Diamond J, Arcasoy S, McDonnough J, Sonett J, Bacchetta M, D Ovidio F, et al. Adipose Gene Expression Profile Changes With Lung Allograft Reperfusion. Am J Transplant. 2017;17:239-245 pubmed publisher
    ..Future evaluation will focus on differential adipose tissue gene expression and the development of PGD after transplant. ..
  34. Yeh J, Hiraoka N, Petryniak B, Nakayama J, Ellies L, Rabuka D, et al. Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase. Cell. 2001;105:957-69 pubmed
    ..These results identify Core1-beta 3GlcNAcT and its cognate extended core1 O-glycans as essential participants in the expression of the MECA-79-positive, HEV-specific L-selectin ligands required for lymphocyte homing. ..
  35. Ho W, Che M, Chou C, Chang H, Jeng Y, Hsu W, et al. B3GNT3 expression suppresses cell migration and invasion and predicts favorable outcomes in neuroblastoma. Cancer Sci. 2013;104:1600-8 pubmed publisher
    ..1,3-N-acetylglucosaminyltransferase-3 (B3GNT3), a member of the ?3GlcNAcT family, is responsible for forming extended core 1 (T antigen) oligosaccharides...
  36. McMichael T, Zhang L, Chemudupati M, Hach J, Kenney A, Hang H, et al. The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity. J Biol Chem. 2017;292:21517-21526 pubmed publisher
    Interferon-induced transmembrane protein 3 (IFITM3) is a cellular endosome- and lysosome-localized protein that restricts numerous virus infections. IFITM3 is activated by palmitoylation, a lipid posttranslational modification...
  37. Carter T, Hebbring S, Liu J, Mosley J, Shaffer C, Ivacic L, et al. Pilot screening study of targeted genetic polymorphisms for association with seasonal influenza hospital admission. J Med Virol. 2017;: pubmed publisher
    ..Cases and controls had similar allele frequencies for variant rs12252 in interferon-inducible transmembrane protein 3 (IFITM3) (P?>?0...
  38. Shiraishi N, Natsume A, Togayachi A, Endo T, Akashima T, Yamada Y, et al. Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family. J Biol Chem. 2001;276:3498-507 pubmed
    ..Considering the differences in substrate specificity and distribution, each beta1,3-N-acetylglucosaminyltransferase may play different roles. ..
  39. Zhang W, Hou T, Niu C, Song L, Zhang Y. B3GNT3 Expression Is a Novel Marker Correlated with Pelvic Lymph Node Metastasis and Poor Clinical Outcome in Early-Stage Cervical Cancer. PLoS ONE. 2015;10:e0144360 pubmed publisher
    The β1,3-N-acetylglucosaminyltransferase-3 gene (B3GNT3) encodes a member of the B3GNT family that functions as the backbone structure of dimeric sialyl-Lewis A and is involved in L-selectin ligand biosynthesis, lymphocyte homing and ..
  40. Chesarino N, Compton A, McMichael T, Kenney A, Zhang L, Soewarna V, et al. IFITM3 requires an amphipathic helix for antiviral activity. EMBO Rep. 2017;18:1740-1751 pubmed publisher
    Interferon-induced transmembrane protein 3 (IFITM3) is a cellular factor that blocks virus fusion with cell membranes. IFITM3 has been suggested to alter membrane curvature and fluidity, though its exact mechanism of action is unclear...
  41. Cerhan J, Ansell S, Fredericksen Z, Kay N, Liebow M, Call T, et al. Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma. Blood. 2007;110:4455-63 pubmed
    ..20; CI 1.77-15.3), SELPLG M264V (OR = 3.20; CI 1.48-6.91), UNC84B G671S (OR = 1.50; CI 1.12-2.00), B3GNT3 H328R (OR = 0.74; CI 0.59-0.93), and BAT2 V1883L (OR = 0.64; CI 0.45-0.90)...
  42. Yokoyama Kobayashi M, Yamaguchi T, Sekine S, Kato S. Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank. Gene. 1999;228:161-7 pubmed
    ..This fibrin sheet method was successfully applied to select five novel cDNA clones encoding putative type II membrane proteins from a human full-length cDNA bank. ..
  43. Amado M, Almeida R, Schwientek T, Clausen H. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. Biochim Biophys Acta. 1999;1473:35-53 pubmed
  44. Correani V, Di Francesco L, Mignogna G, Fabrizi C, Leone S, Giorgi A, et al. Plasma Membrane Protein Profiling in Beta-Amyloid-Treated Microglia Cell Line. Proteomics. 2017;17: pubmed publisher
    ..phenotype in AD damaged tissues MAP/microtubule affinity-regulating kinase 3 (MARK3), Interferon-induced transmembrane protein 3 (IFITM3), Annexins A5 and A7 (ANXA5, ANXA7) and Neuropilin-1 (NRP1), all proteins known to be involved in ..
  45. Randolph A, Yip W, Allen E, Rosenberger C, Agan A, Ash S, et al. Evaluation of IFITM3 rs12252 Association With Severe Pediatric Influenza Infection. J Infect Dis. 2017;216:14-21 pubmed publisher
    Interferon-induced transmembrane protein 3 (IFITM3) restricts endocytic fusion of influenza virus. IFITM3 rs12252_C, a putative alternate splice site, has been associated with influenza severity in adults...
  46. He M, Wu C, Xu J, Guo H, Yang H, Zhang X, et al. A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and ? fetoprotein and their associations with cancer risk. Gut. 2014;63:143-51 pubmed publisher
    ..3, FUT2-CA11 at 19q13.3 and B3GNT3 at 19p13.1; p=1.16×10(-13)-3.30×10(-290)); four for CEA (ABO at 9q34.2, FUT6 at 19p13.3, FUT2 at 19q13...