B3GNT2

Summary

Gene Symbol: B3GNT2
Description: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
Alias: 3-Gn-T1, 3-Gn-T2, B3GN-T2, B3GNT, B3GNT-2, B3GNT1, BETA3GNT, BGNT2, BGnT-2, beta-1, beta3Gn-T1, beta3Gn-T2, N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1, beta-1,3-N-acetylglucosaminyltransferase bGnT-1, beta-1,3-N-acetylglucosaminyltransferase bGnT-2
Species: human
Products:     B3GNT2

Top Publications

  1. Shiraishi N, Natsume A, Togayachi A, Endo T, Akashima T, Yamada Y, et al. Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family. J Biol Chem. 2001;276:3498-507 pubmed
    ..Considering the differences in substrate specificity and distribution, each beta1,3-N-acetylglucosaminyltransferase may play different roles. ..
  2. Seko A, Yamashita K. Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells. J Biol Chem. 2008;283:33094-100 pubmed publisher
    ..These results raise a possibility that up-regulation of beta3Gn-T8 in differentiated HL-60 cells increases poly-N-acetyllactosamine chains by activating intrinsic beta3Gn-T2. ..
  3. Aterido A, Canete J, Tornero J, Ferrandiz C, Pinto J, Gratacos J, et al. Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis. Ann Rheum Dis. 2019;78: pubmed publisher
    ..We identified a new PsA risk single-nucleotide polymorphism at B3GNT2 locus (p=1.10e-08)...
  4. Pegolo S, Bergamaschi M, Gasperi F, Biasioli F, Cecchinato A, Bittante G. Integrated PTR-ToF-MS, GWAS and biological pathway analyses reveal the contribution of cow's genome to cheese volatilome. Sci Rep. 2018;8:17002 pubmed publisher
    ..g. CSN3, GNRHR and FAM169A), fat (e.g. AGPAT3, SCD5, and GPAM) and carbohydrate (e.g. B3GNT2, B4GALT1, and PHKB) metabolism...
  5. Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, et al. A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma. Genome Med. 2014;6:105 pubmed publisher
    ..of ITGA5, SEMA3A, KIF4A, IL20RB, SLC20A1, CDC45, PXN, SSX3 and TMEM26 was correlated with shorter survival while B3GNT1, NOSTRIN and CADPS down-regulation was associated with poor outcome...
  6. Willer T, Inamori K, Venzke D, Harvey C, Morgensen G, Hara Y, et al. The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation. elife. 2014;3: pubmed publisher
    ..Here we show that FKRP, FKTN, TMEM5 and B4GAT1 (formerly known as B3GNT1) localize to the Golgi and contribute to the O-mannosyl post-phosphorylation modification of α-DG...
  7. Zhang W, Hou T, Niu C, Song L, Zhang Y. B3GNT3 Expression Is a Novel Marker Correlated with Pelvic Lymph Node Metastasis and Poor Clinical Outcome in Early-Stage Cervical Cancer. PLoS ONE. 2015;10:e0144360 pubmed publisher
    The β1,3-N-acetylglucosaminyltransferase-3 gene (B3GNT3) encodes a member of the B3GNT family that functions as the backbone structure of dimeric sialyl-Lewis A and is involved in L-selectin ligand biosynthesis, lymphocyte homing and ..
  8. Crisà A, Ferré F, Chillemi G, Moioli B. RNA-Sequencing for profiling goat milk transcriptome in colostrum and mature milk. BMC Vet Res. 2016;12:264 pubmed
    ..in colostrum than in mature milk, with eight expressed at very high levels (SLCA3, GMSD, NME2, SLC2A1, B4GALT1, B3GNT2, NANS, HEXB)...
  9. Zhou D, Dinter A, Gutierrez Gallego R, Kamerling J, Vliegenthart J, Berger E, et al. A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases. Proc Natl Acad Sci U S A. 1999;96:406-11 pubmed
    Human and mouse cDNAs encoding a new beta-1, 3-N-acetylglucosaminyltransferase (beta3GnT) have been isolated from fetal and newborn brain libraries...

More Information

Publications24

  1. Amado M, Almeida R, Schwientek T, Clausen H. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. Biochim Biophys Acta. 1999;1473:35-53 pubmed
  2. Timbers T, Garland S, Mohan S, Flibotte S, Edgley M, Muncaster Q, et al. Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-mutation Strains and Using the Sequence Kernel Association Test (SKAT). PLoS Genet. 2016;12:e1006235 pubmed publisher
    ..Notably, BGNT-1.1 is the orthologue of human B3GNT1/B4GAT1, a glycosyltransferase associated with Walker-Warburg syndrome (WWS)...
  3. Mkhikian H, Mortales C, Zhou R, Khachikyan K, Wu G, Haslam S, et al. Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis. elife. 2016;5: pubmed publisher
    ..branching enzymes as well as the trans-Golgi poly-LacNAc extension enzyme ?1,3-N-acetylglucosaminyltransferase (B3GNT)...
  4. Clark A, Guimarães da Costa V, Bandeira Costa L, Bezerra Cavalcanti C, De Melo Rêgo M, Beltrão E. Differential expression patterns of N-acetylglucosaminyl transferases and polylactosamines in uterine lesions. Eur J Histochem. 2014;58:2334 pubmed publisher
    ..In addition, polyLacNAc expression only in the nucleus can be associated a poor prognostic in uterine lesions. ..
  5. Praissman J, Live D, Wang S, Ramiah A, Chinoy Z, Boons G, et al. B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycan. elife. 2014;3: pubmed publisher
    Recent studies demonstrated that mutations in B3GNT1, an enzyme proposed to be involved in poly-N-acetyllactosamine synthesis, were causal for congenital muscular dystrophy with hypoglycosylation of α-dystroglycan (secondary ..
  6. Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, et al. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nat Genet. 2012;44:511-6 pubmed publisher
    ..0 × 10(-8), including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2...
  7. Venkitachalam S, Revoredo L, Varadan V, Fecteau R, Ravi L, Lutterbaugh J, et al. Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer. Sci Rep. 2016;6:23642 pubmed publisher
    ..In particular, we observed an enrichment of mutations in genes (B3GNT2, B4GALT2, ST6GALNAC2) involved in the biosynthesis of N- and Cores 1-3 O-linked glycans in the colon, accounting ..
  8. Zheng H, Li Y, Ji C, Li J, Zhang J, Yin G, et al. Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase. Mol Biol Rep. 2004;31:171-5 pubmed
    ..The human beta3GnTL1 is located to chromosome 17q25.3 by comparison of its cDNA with human gemome database. RT-PCR result shows the beta3GnTL1 is expressed at various levels in most of tissues examined. ..
  9. Mare L, Trinchera M. Suppression of beta 1,3galactosyltransferase beta 3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans. Eur J Biochem. 2004;271:186-94 pubmed
    We investigated the role of beta 3 Gal-T5, a member of the beta 1,3galactosyltransferase (beta 1,3Gal-T) family, in cancer-associated glycosylation, focusing on the expression of sialyl-Lewis a (sLea, the epitope of CA19...
  10. Qiu H, Duan W, Shu J, Cheng H, Wang W, Huang X, et al. B3GNT2, a polylactosamine synthase, regulates glycosylation of EGFR in H7721 human hepatocellular carcinoma cells. Asian Pac J Cancer Prev. 2014;15:10875-8 pubmed
    ..Among the four glycosyltransferases with altered expression, GnT-V was most elevated by EGF, while GnT-V and B3GNT2 were most declined by ATRA...
  11. Hayashi N, Nakamori S, Okami J, Nagano H, Dono K, Umeshita K, et al. Association between expression levels of CA 19-9 and N-acetylglucosamine-beta;1,3-galactosyltransferase 5 gene in human pancreatic cancer tissue. Pathobiology. 2004;71:26-34 pubmed
    ..beta3Gal-T5 is presumed to be responsible for the synthesis of CA 19-9 in pancreatic cancer tissue. ..
  12. Ju T, Cummings R. A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase. Proc Natl Acad Sci U S A. 2002;99:16613-8 pubmed
  13. Chen W, Wang W, Okada Y, Chang W, Chou Y, Chang H, et al. rs2841277 (PLD4) is associated with susceptibility and rs4672495 is associated with disease activity in rheumatoid arthritis. Oncotarget. 2017;8:64180-64190 pubmed publisher
    ..influence expression of LINC00638 and AHNAK2 and rs4672495 is able to influence the expression of B3GNT2...
  14. Isshiki S, Kudo T, Nishihara S, Ikehara Y, Togayachi A, Furuya A, et al. Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins. J Biol Chem. 2003;278:36611-20 pubmed
    ..beta3Gal-T5, controlled by the intestinal homeoproteins, may play an important role in the specific function of intestinal cells by modifying the carbohydrate structure of glycoproteins. ..
  15. Reveille J, Sims A, Danoy P, Evans D, Leo P, Pointon J, et al. Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nat Genet. 2010;42:123-7 pubmed publisher
    ..3 x 10(-12)). This study reports four genetic loci associated with ankylosing spondylitis risk and identifies a major role for the interleukin (IL)-23 and IL-1 cytokine pathways in disease susceptibility. ..