B3GALTL

Summary

Gene Symbol: B3GALTL
Description: beta 1,3-galactosyltransferase-like
Alias: B3GLCT, B3GTL, B3Glc-T, Gal-T, beta3Glc-T, UDP-GAL:beta-GlcNAc beta-1,3-galactosyltransferase-like, beta 3-glycosyltransferase-like, beta-1,3-glucosyltransferase, beta-3-glycosyltransferase-like
Species: human

Top Publications

  1. ncbi Complementary DNA cloning for galactosyltransferase associated with tumor and determination of antigenic epitopes recognized by specific monoclonal antibodies
    T Uejima
    Department of Microbiology, Keio University School of Medicine, Tokyo, Japan
    Cancer Res 52:6158-63. 1992
  2. ncbi Retinoic acid-induced differentiation of the mouse teratocarcinoma cell line F9 is accompanied by an increase in the activity of UDP-galactose: beta-D-galactosyl-alpha 1,3-galactosyltransferase
    R D Cummings
    Department of Biochemistry, University of Georgia, Athens 30602
    J Biol Chem 263:511-9. 1988
  3. ncbi Effect of hyperthermia on activity of three glycosyltransferases in Chinese hamster ovary cells
    K J Henle
    Department of Medicine, University of Arkansas for Medical Sciences, Little Rock 72205
    Cancer Res 48:5717-21. 1988
  4. ncbi Alterations of cell surface carbohydrates and inhibition of metastatic property of murine melanomas by alpha 1,3 galactosyltransferase gene transfection
    E Gorelik
    Pittsburgh Cancer Institute, University of Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 55:4168-73. 1995
  5. doi Application of cyclophosphamide-induced tolerance in alpha1,3-galactosyltransferase knockout mice presensitized with Gal alpha 1-3Gal beta-4-GlcNAc antigens
    Tatsushi Onzuka
    Department of Cardiovascular Surgery, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Surg Today 38:807-14. 2008
  6. ncbi Biosynthesis of the storage polysaccharide from the snail Biomphalaria glabrata, identification and specificity of a branching beta 1-->6 galactosyltransferase
    K Stangier
    , , Germany
    J Comp Physiol B 165:278-90. 1995
  7. ncbi Variants of the beta 1,3-galactosyltransferase CgtB from the bacterium Campylobacter jejuni have distinct acceptor specificities
    Stéphane Bernatchez
    Institute for Biological Sciences, National Research Council Canada, Ottawa, ON, Canada
    Glycobiology 17:1333-43. 2007
  8. ncbi Characterization of the synthesis and expression of the GTA-kinase from transformed and normal rodent cells
    M Kerr
    Department of Oral Biology, University of Florida, Gainesville 32610
    Biochim Biophys Acta 1218:375-87. 1994
  9. ncbi Galactosyltransferase function during mammalian fertilization
    B Nixon
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cells Tissues Organs 168:46-57. 2001
  10. pmc Enzyme interactions in heparan sulfate biosynthesis: uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo
    M A Pinhal
    Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0687, USA
    Proc Natl Acad Sci U S A 98:12984-9. 2001

Scientific Experts

Detail Information

Publications135 found, 100 shown here

  1. ncbi Complementary DNA cloning for galactosyltransferase associated with tumor and determination of antigenic epitopes recognized by specific monoclonal antibodies
    T Uejima
    Department of Microbiology, Keio University School of Medicine, Tokyo, Japan
    Cancer Res 52:6158-63. 1992
    ..These results demonstrate that GAT is produced by aberrant proteolytic cleavage at the different site, closer to the membrane-binding domain, from the normal GalT...
  2. ncbi Retinoic acid-induced differentiation of the mouse teratocarcinoma cell line F9 is accompanied by an increase in the activity of UDP-galactose: beta-D-galactosyl-alpha 1,3-galactosyltransferase
    R D Cummings
    Department of Biochemistry, University of Georgia, Athens 30602
    J Biol Chem 263:511-9. 1988
    ..We have found that extracts from both cell types contain these enzyme activities; differentiation, however, does not result in substantial changes in any of these activities...
  3. ncbi Effect of hyperthermia on activity of three glycosyltransferases in Chinese hamster ovary cells
    K J Henle
    Department of Medicine, University of Arkansas for Medical Sciences, Little Rock 72205
    Cancer Res 48:5717-21. 1988
    ..These data, together with other published results, suggest that expression of thermotolerance may be associated with enhanced glycosylation of intracellular proteins...
  4. ncbi Alterations of cell surface carbohydrates and inhibition of metastatic property of murine melanomas by alpha 1,3 galactosyltransferase gene transfection
    E Gorelik
    Pittsburgh Cancer Institute, University of Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 55:4168-73. 1995
    ..Thus, the use of specific glycosyltransferase cDNA transfection presents direct experimental confirmation of the importance of cell membrane carbohydrates in the regulation of metastatic properties of tumor cells...
  5. doi Application of cyclophosphamide-induced tolerance in alpha1,3-galactosyltransferase knockout mice presensitized with Gal alpha 1-3Gal beta-4-GlcNAc antigens
    Tatsushi Onzuka
    Department of Cardiovascular Surgery, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Surg Today 38:807-14. 2008
    ..In the present study, we applied our tolerance induction conditioning in presensitized recipient mice...
  6. ncbi Biosynthesis of the storage polysaccharide from the snail Biomphalaria glabrata, identification and specificity of a branching beta 1-->6 galactosyltransferase
    K Stangier
    , , Germany
    J Comp Physiol B 165:278-90. 1995
    ..It is thus concluded that at least three different enzymes are involved in the biosynthesis of this snail galactan...
  7. ncbi Variants of the beta 1,3-galactosyltransferase CgtB from the bacterium Campylobacter jejuni have distinct acceptor specificities
    Stéphane Bernatchez
    Institute for Biological Sciences, National Research Council Canada, Ottawa, ON, Canada
    Glycobiology 17:1333-43. 2007
    ....
  8. ncbi Characterization of the synthesis and expression of the GTA-kinase from transformed and normal rodent cells
    M Kerr
    Department of Oral Biology, University of Florida, Gainesville 32610
    Biochim Biophys Acta 1218:375-87. 1994
    ..Western blot analysis confirmed a translocation from a cytoplasmic localization in both LSTRA and quiescent salivary cells to a membrane-associated localization in YC-8 and proliferating salivary cells...
  9. ncbi Galactosyltransferase function during mammalian fertilization
    B Nixon
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cells Tissues Organs 168:46-57. 2001
    ..A large scaffolding protein has been identified that associates with the GalT cytoplasmic domain and may be responsible for orchestrating its signal transduction capacities that lead to the acrosome reaction...
  10. pmc Enzyme interactions in heparan sulfate biosynthesis: uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo
    M A Pinhal
    Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0687, USA
    Proc Natl Acad Sci U S A 98:12984-9. 2001
    ..These findings provide in vivo evidence for the formation of complexes among enzymes involved in heparan sulfate biosynthesis. The functional significance of these complexes may relate to the rapidity of heparan sulfate formation...
  11. doi Lactose synthase components in milk: concentrations of alpha-lactalbumin and beta1,4-galactosyltransferase in milk of cows from several breeds at various stages of lactation
    G T Bleck
    Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
    Reprod Domest Anim 44:241-7. 2009
    ..In conclusion, this survey shows that the two components of lactose synthase are each correlated to protein concentration and individually correlated to the concentration of other milk components and stage of lactation...
  12. doi The expression patterns of beta1,4 galactosyltransferase I and V mRNAs, and Galbeta1-4GlcNAc group in rat gastrocnemius muscles post sciatic nerve injury
    Meijuan Yan
    The Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, People s Republic of China
    Glycoconj J 25:685-701. 2008
    ....
  13. ncbi Carbohydrates and derivatives as potential drug candidates with emphasis on the selectin and linear-B area
    R Ohrlein
    Novartis Pharma Ltd, Basle, CH 4002, Switzerland
    Mini Rev Med Chem 1:349-61. 2001
    ..The presented findings may also be useful to design potential glycosyltransferase inhibitors...
  14. ncbi Biosynthesis in vitro of neolactotetraosylceramide by a galactosyltransferase from mouse T-lymphoma: purification and kinetic studies; synthesis of neolacto and polylactosamine core
    M Basu
    Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556, USA
    Glycoconj J 13:423-32. 1996
    ....
  15. ncbi Human sperm plasma membranes possess alpha-D-mannosidase activity but no galactosyltransferase activity
    D R Tulsiani
    Department of Obstetrics and Gynecology, Vanderbilt School of Medicine, Nashville, Tennessee 37232 2633
    Biol Reprod 42:843-58. 1990
    ..The potential ligand-like role of human sperm surface alpha-D-mannosidase and other sperm surface enzymes during fertilization is discussed...
  16. doi Expression of beta-1,4-galactosyltransferase I in rat Schwann cells
    Huiguang Yang
    Department of Orthopaedics, Affiliated Jiangying Hospital of Nantong University, The Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu Province 226001, P R China
    J Cell Biochem 108:75-86. 2009
    ....
  17. pmc Biochemical characterization of UDP-Gal:GlcNAc-pyrophosphate-lipid β-1,4-Galactosyltransferase WfeD, a new enzyme from Shigella boydii type 14 that catalyzes the second step in O-antigen repeating-unit synthesis
    Changchang Xu
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    J Bacteriol 193:449-59. 2011
    ..Our study revealed that the β4-GalT WfeD is a novel enzyme that has virtually no sequence similarity to mammalian β4-GalT, although it catalyzes a similar reaction...
  18. ncbi UDP galactose:ceramide galactosyltransferase and glutamate/aspartate transporter. Copurification, separation and characterization of the two glycoproteins
    S Schulte
    Institute of Biochemistry, Medical Faculty, University of Cologne, Germany
    Eur J Biochem 233:947-53. 1995
    ....
  19. ncbi Specific inhibition of an alpha-galactosyltransferase from Trypanosoma brucei by synthetic substrate analogues
    V Kolb
    Physiologisch chemisches Institut der Universität Tübingen, Germany
    Glycoconj J 16:537-44. 1999
    ..Interestingly, other trypanosomal alpha-galactosyltransferases, which modify the GPI membrane anchor, are 2 orders of magnitude less effected by the inhibitor...
  20. ncbi A beta1,4-galactosyltransferase is required for convergent extension movements in zebrafish
    Quentin J Machingo
    Department of Cell Biology, Emory University, Atlanta, GA 30329, USA
    Dev Biol 297:471-82. 2006
    ....
  21. ncbi A novel missense mutation in the galactosyltransferase-I (B4GALT7) gene in a family exhibiting facioskeletal anomalies and Ehlers-Danlos syndrome resembling the progeroid type
    Muhammad Faiyaz-Ul-Haque
    Program in Genetics and Genomic Biology, Department of Genetics, The Hospital for Sick Children, 9th Floor Elm Wing, Rm 9115, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Am J Med Genet A 128:39-45. 2004
    ....
  22. pmc Cloning and characterization of the lipooligosaccharide galactosyltransferase II gene of Haemophilus ducreyi
    S Sun
    Children s Research Institute, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio 43205 2696, USA
    J Bacteriol 182:2292-8. 2000
    ..Thus, the serum sensitivity of strain A77 cannot be attributed to the galactosyltransferase mutation in strain A77...
  23. doi Anti-Gal antibody-mediated skin graft rejection requires a threshold level of Gal expression
    Lisa Murray-Segal
    Immunology Research Centre, St Vincent s Hospital Melbourne and Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia
    Xenotransplantation 15:20-6. 2008
    ....
  24. ncbi Expression of eukaryotic glycosyltransferases in the yeast Pichia pastoris
    Monika Bencúrová
    Glycobiology Division, Institut fur Chemie, Universität für Bodenkultur, Muthgasse 18, A 1190 Vienna, Austria
    Biochimie 85:413-22. 2003
    ..pastoris, an active secreted form of the protein was produced...
  25. doi Structural analysis of α1,3-linked galactose-containing oligosaccharides in Schizosaccharomyces pombe mutants harboring single and multiple α-galactosyltransferase genes disruptions
    Takao Ohashi
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki 6 10 1, Higashi ku, Fukuoka 812 8581, Japan
    Glycobiology 21:340-51. 2011
    ....
  26. ncbi Targeted mutation in beta1,4-galactosyltransferase leads to pituitary insufficiency and neonatal lethality
    Q Lu
    Department of Biochemistry and Molecular Biology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Dev Biol 181:257-67. 1997
    ..The fact that approximately 10% of the GalTase-null mice survive the neonatal period indicates the presence of a previously unrecognized compensatory pathway for glycoprotein hormone glycosylation and/or action...
  27. ncbi Chinese hamster ovary (CHO) cells may express six beta 4-galactosyltransferases (beta 4GalTs). Consequences of the loss of functional beta 4GalT-1, beta 4GalT-6, or both in CHO glycosylation mutants
    J Lee
    Department of Cell Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Biol Chem 276:13924-34. 2001
    ..They may be used in glycosylation engineering and in investigating roles for beta4GalT-1 and beta4GalT-6 in generating specific glycan ligands...
  28. ncbi Conformational changes induced by binding UDP-2F-galactose to alpha-1,3 galactosyltransferase- implications for catalysis
    Haryati Jamaluddin
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    J Mol Biol 369:1270-81. 2007
    ....
  29. ncbi Allosensitization does not increase the risk of xenoreactivity to alpha1,3-galactosyltransferase gene-knockout miniature swine in patients on transplantation waiting lists
    Banny S Wong
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, USA
    Transplantation 82:314-9. 2006
    ..We have investigated this question using sera from such patients on GalT-KO target cells...
  30. ncbi alpha-Lactalbumin (LA) stimulates milk beta-1,4-galactosyltransferase I (beta 4Gal-T1) to transfer glucose from UDP-glucose to N-acetylglucosamine. Crystal structure of beta 4Gal-T1 x LA complex with UDP-Glc
    B Ramakrishnan
    Structural Glycobiology Section, Laboratory of Experimental and Computational Biology, Center for Cancer Research, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 276:37665-71. 2001
    ..Based on the present kinetic and crystal structural studies, a possible explanation for the role of LA in the Glc-T activity has been proposed...
  31. ncbi Studies on glycolipid antigens in small intestine and pancreas from alpha1,3-galactosyltransferase knockout miniature swine
    Mette Diswall
    Department of Surgery, Sahlgrenska University Hospital campus Ostra, Goteborg, Sweden
    Transplantation 84:1348-56. 2007
    ..Galalpha1,3Gal determinant elimination may expose cryptic carbohydrate antigens and/or generate new antigens. This is the first biochemical study of carbohydrate antigens in GalT-KO pig organs...
  32. ncbi Modulation of two distinct galactosyltransferase activities in populations of mouse peritoneal macrophages
    B T Sheares
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139
    J Immunol 139:3748-52. 1987
    ..These results indicate that glycosyltransferase activities are modulated in populations of mouse macrophages, and that these changes correlate with changes in cell surface lactosaminoglycans reported previously...
  33. ncbi Non-depleting anti-CD4, but not anti-CD8, antibody induces long-term survival of xenogeneic and allogeneic hearts in alpha1,3-galactosyltransferase knockout (GT-Ko) mice
    A S Chong
    Department of General Surgery, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Xenotransplantation 7:275-83. 2000
    ..Thus, immunosuppression with anti-CD4 mAb therapy induces long-term survival of allografts more effectively than to xenografts...
  34. pmc Galectin-1 as a fusion partner for the production of soluble and folded human beta-1,4-galactosyltransferase-T7 in E. coli
    Marta Pasek
    Structural Glycobiology Section, SAIC Frederick, Inc, Center for Cancer Research Nanobiology Program, Center for Cancer Research, NCI Frederick, Frederick, MD, USA
    Biochem Biophys Res Commun 394:679-84. 2010
    ..The eluted protein is enzymatically active, and shows CD spectra comparable to the folded beta4Gal-T1. The engineered galectin-1 vector could prove to be a valuable tool for expressing other proteins in E. coli...
  35. ncbi Comparison of bipyridyl, maltol and kojic acid action as organic vanadium ligands on activity of galactosyltransferase (EC 2.4.1.38), some physiological parameters and ultrastructure of Golgi complexes in rat hepatocytes
    Wojciech Dabros
    Department of Clinical and Experimental Pathomorphology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Folia Histochem Cytobiol 45:239-44. 2007
    ....
  36. ncbi Glycerophosphorylcholine phosphocholine phosphodiesterase activity in cultured oligodendrocytes, astrocytes, and central nervous tissue of dysmyelinating rodent mutants
    J Yuan
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Neurosci Res 31:68-74. 1992
    ..The highest activity of GPC and pNP phosphocholine phosphodiesterases as with CNPase and C gal T was found in the pure cultured oligodendrocytes...
  37. pmc Overexpressing sperm surface beta 1,4-galactosyltransferase in transgenic mice affects multiple aspects of sperm-egg interactions
    A Youakim
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    J Cell Biol 126:1573-83. 1994
    ..Although sperm GalTase is required for fertilization by serving as a receptor for the egg zona pellucida, excess surface GalTase is counterproductive to successful sperm-egg binding...
  38. ncbi Structure and function in galactosyltransferase. Sequence locations of alpha-lactalbumin binding site, thiol groups, and disulfide bond
    S P Yadav
    Department of Biochemistry and Molecular Biology, University of Miami, Florida 33136
    J Biol Chem 266:698-703. 1991
    ....
  39. pmc Cloning, functional expression, and characterization of the raffinose oligosaccharide chain elongation enzyme, galactan:galactan galactosyltransferase, from common bugle leaves
    Esther M Tapernoux-Lüthi
    Institute of Plant Biology, University of Zurich, Zollikerstrasse 107, Ch 8008 Zurich, Switzerland
    Plant Physiol 134:1377-87. 2004
    ....
  40. ncbi Characterization of the rat alpha(1,3)galactosyltransferase: evidence for two independent genes encoding glycosyltransferases that synthesize Galalpha(1,3)Gal by two separate glycosylation pathways
    Simon G Taylor
    John Connell Laboratory for Glycobiology, Austin Research Institute, Austin and Repatriation Medical Centre, Heidelberg, Vic, 3084, Australia
    Glycobiology 13:327-37. 2003
    ..Furthermore iGb3 synthase was found to be distinct from alpha(1,3)GT with its ability to synthesize poly-alpha-Gal glycolipid structures...
  41. ncbi The influence of BMOV [bis(maltolato)oxovanadium(IV)] on biochemical and morphological alterations characteristic for streptozotocin-diabetic rat liver Golgi complexes
    Wojciech Dabros
    Department of Clinical and Experimental Pathomorphology, Collegium Medicum, Jagiellonian University, Krakow
    Pol J Pathol 53:205-13. 2002
    ..In the pVD group a different structure of AG was seen: short terminally dilated cisternae, sometimes only semicircular and arched. In rats treated 7 days with BMOV (the D+V group) the "normalisation" of morphology of liver AG was noted...
  42. doi Enhanced expression of beta 3-galactosyltransferase 5 activity is sufficient to induce in vivo synthesis of extended type 1 chains on lactosylceramides of selected human colonic carcinoma cell lines
    Chi Hung Lin
    Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program, Academia Sinica, Taipei 115, Taiwan
    Glycobiology 19:418-27. 2009
    ....
  43. ncbi Insulin-like effects on liver Golgi membrane preparations of bis(oxalato)oxovanadate(IV) complex ion, a new vanadate compound
    A M Kordowiak
    Department of Animal Biochemistry, Jagiellonian University, , Poland
    Horm Metab Res 29:101-5. 1997
    ..This is similar to insulin influence on the galactosyltransferase activity reported previously by Kaczmarski et al. in 1981 (4) and Kordowiak et al. in 1981 (5)...
  44. ncbi Sperm from beta 1,4-galactosyltransferase-null mice are refractory to ZP3-induced acrosome reactions and penetrate the zona pellucida poorly
    Q Lu
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30302, USA
    Development 124:4121-31. 1997
    ....
  45. ncbi UDP-6-deoxy-6-fluoro-alpha-D-galactose binds to two different galactosyltransferases, but neither can effectively catalyze transfer of the modified galactose to the appropriate acceptor
    C L Schengrund
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Carbohydr Res 319:24-8. 1999
    ..Acetylation of 3 gave crystalline 1,2,3,4-tetra-O-acetyl-6-deoxy-6-fluoro-beta-D-galactopyranose, which was converted to the corresponding 1-alpha-phosphate and used for the synthesis of 6...
  46. ncbi Expression of the ceramide galactosyltransferase gene during myelination of the mouse nervous system. Comparison with the genes encoding myelin basic proteins, choline kinase and CTP:phosphocholine cytidylyltransferase
    B Garbay
    Laboratoire de Biogenese Membranaire, URA CNRS 1811, IBGC du CNRS, Universite de Bordeaux II, France
    Brain Res Dev Brain Res 83:119-24. 1994
    ..Our results clearly indicate that the deficit in the accumulation of the galactosylceramides documented for this mutant is well correlated to a reduced CGT gene expression...
  47. ncbi Phosphorylation and sulfation of oligosaccharide substrates critically influence the activity of human beta1,4-galactosyltransferase 7 (GalT-I) and beta1,3-glucuronosyltransferase I (GlcAT-I) involved in the biosynthesis of the glycosaminoglycan-protein l
    Sandrine Gulberti
    UMR 7561 CNRS Université Henri Poincaré Nancy 1, Faculte de Medecine, 54505 Vandoeuvre les Nancy, France
    J Biol Chem 280:1417-25. 2005
    ..Altogether, we demonstrated that oligosaccharide modifications of the linkage region control the specificity of the glycosyltransferases, a process that may regulate maturation and processing of glycosaminoglycan chains...
  48. doi Structural basis of UDP-galactose binding by alpha-1,3-galactosyltransferase (alpha3GT): role of negative charge on aspartic acid 316 in structure and activity
    Percy Tumbale
    Department of Biomedical Science, Florida Atlantic University, 777 Glades Road, Boca Raton, Florida 33431, USA
    Biochemistry 47:8711-8. 2008
    ....
  49. ncbi Differences in in vivo acceptor specificity of two galactosyltransferases, the gmh3+ and gma12+ gene products from Schizosaccharomyces pombe
    T Yoko-o
    National Institute of Bioscience and Human Technology, Tsukuba, Ibaraki, Japan
    Eur J Biochem 257:630-7. 1998
    ..It appears that the gmh3+ gene product transfers galactose to N-linked oligosaccharide, while the gma12+ gene product transfers galactose to both N-linked and O-linked oligosaccharides...
  50. ncbi Mouse beta 1,3-galactosyltransferase (GA1/GM1/GD1b synthase): protein characterization, tissue expression, and developmental regulation in neural retina
    J L Daniotti
    Centro de Investigaciones en Quimica Biologica de Cordoba, CIQUIBIC UNC CONICET, Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Cordoba, Argentina
    J Neurosci Res 58:318-27. 1999
    ..The developmental pattern of mRNA expression was temporally coincident with that of Gal-T2 activity expression, indicating that this enzyme is under transcriptional control in the neural retina...
  51. ncbi A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3
    R Almeida
    School of Dentistry, University of Copenhagen, Norre Alle 20, DK 2200 Copenhagen N, Denmark
    J Biol Chem 272:31979-91. 1997
    ..The existence of multiple beta4-galactosyltransferases with the same or overlapping functions may be relevant for interpretation of biological functions previously assigned to beta4Gal-T1...
  52. ncbi Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis
    T Schwientek
    School of Dentistry, University of Copenhagen, Norre Alle 20, 2200 Copenhagen N, Denmark
    J Biol Chem 273:29331-40. 1998
    ..beta4Gal-T4 represents a new member of the beta4-galactosyltransferase family. Its kinetic parameters suggest unique functions in the synthesis of neolactoseries glycosphingolipids...
  53. ncbi Identification of core 1 O-glycan T-synthase from Caenorhabditis elegans
    Tongzhong Ju
    Department of Biochemistry and Molecular Biology, Oklahoma Center for Medical Glycobiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Glycobiology 16:947-58. 2006
    ..These results show that the Ce-T-synthase is a functional ortholog to the human T-synthase in generating core 1 O-glycans and open new avenues to explore O-glycan function in this model organism...
  54. pmc Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase
    T Sato
    Department of Biosignal Research, Tokyo Metropolitan Institute of Gerontology, Japan
    Proc Natl Acad Sci U S A 95:472-7. 1998
    ..Northern blot analysis of 24 human tissues showed that they all express the beta-1,4-GalT II transcript, although the levels varied. These results indicate that human cells contain another beta-1,4-GalT...
  55. doi Subcompartment localization of the side chain xyloglucan-synthesizing enzymes within Golgi stacks of tobacco suspension-cultured cells
    Laurence Chevalier
    Laboratoire Glycobiologie et Matrice Extracellulaire Végétale, UPRES EA 4358, Institut Federatif de Recherche Multidisciplinaire sur les Peptides 23, Plate forme de Recherche en Imagerie Cellulaire de Haute Normandie PRIMACEN, IBiSA, Universite de Rouen, 76821 Mont Saint Aignan Cedex, France
    Plant J 64:977-89. 2010
    ....
  56. ncbi Anti-Gal antibody-mediated allograft rejection in alpha1,3-galactosyltransferase gene knockout mice: a model of delayed xenograft rejection
    M J Pearse
    Immunology Research Centre, St Vincent s Hospital, Fitzroy, Australia
    Transplantation 66:748-54. 1998
    ....
  57. pmc Molecular cloning and functional characterization of a Lepidopteran insect beta4-N-acetylgalactosaminyltransferase with broad substrate specificity, a functional role in glycoprotein biosynthesis, and a potential functional role in glycolipid biosynthesis
    Nadia Vadaie
    Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071, USA
    J Biol Chem 279:33501-18. 2004
    ....
  58. doi 41 RAPID PRODUCTION OF α-1,3-GALACTOSYLTRANSFERASE-DEFICIENT MINIATURE PIGS BY NUCLEAR TRANSFER FOLLOWING NEONATAL SKIN BIOPSY AND LOSS OF HETEROZYGOSITY
    Y J Kim
    Dankook University, Cheonan si, Chungnam, South Korea
    Reprod Fertil Dev 25:168. 2012
    ..Such a procedure may be beneficial for the production of other homozygote KO animals, especially in species that require substantial periods of gestation such as pigs...
  59. doi Investigating the structural dynamics of α-1,4-galactosyltransferase C from Neisseria meningitidis by nuclear magnetic resonance spectroscopy
    Patrick H W Chan
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
    Biochemistry 52:320-32. 2013
    ..Although further studies are required to link the detected motions of LgtC with its enzymatic mechanism, this work clearly demonstrates the complex structural dynamics of a model glycosyltransferase...
  60. pmc Transfer specificity of detergent-solubilized fenugreek galactomannan galactosyltransferase
    Mary E Edwards
    Department of Biological Sciences, University of Stirling, Stirling FK9 4LA, Scotland
    Plant Physiol 129:1391-7. 2002
    ..These observations are incorporated into a refined model for enzyme interaction in galactomannan biosynthesis...
  61. ncbi Sperm from beta1,4-galactosyltransferase I-null mice exhibit precocious capacitation
    Carey Rodeheffer
    Department of Cell Biology, Graduate Program in Biochemistry, Cell and Developmental Biology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Development 131:491-501. 2004
    ..These data suggest that GalT I may function as a negative regulator of capacitation in the sperm head by suppressing intracellular signaling pathways that promote this process...
  62. doi Nucleofection-mediated α1,3-galactosyltransferase gene inactivation and membrane cofactor protein expression for pig-to-primate xenotransplantation
    Nayoung Ko
    a Animal Biotechnology Division, National Institute of Animal Science, RDA, Suwon, South Korea
    Anim Biotechnol 24:253-67. 2013
    ..GalT gene expression was downregulated in these 2 clones. Importantly, MCP was shown to be efficiently expressed at the cell surface and to efficiently protect cell lysis against normal human complement serum attack in vitro. ..
  63. ncbi In vitro biosynthesis of galactans by membrane-bound galactosyltransferase from radish ( Raphanus sativus L.) seedlings
    Hideaki Kato
    Department of Biochemistry and Molecular Biology, Faculty of Science, Saitama University, 255 Shimo okubo, Saitama 338 8570, Japan
    Planta 217:271-82. 2003
    ..The membrane preparation also incorporated [(14)C]Gal into beta-(1-->4)-galactan, indicating that the membranes contained different types of GalT isoform catalyzing the synthesis of different types of galactosidic linkage...
  64. ncbi Cell surface beta-1,4-galactosyltransferase-I activates G protein-dependent exocytotic signaling
    X Shi
    Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Development 128:645-54. 2001
    ..These results demonstrate directly that GalTase functions as a ZP3 receptor and following aggregation, is capable of activating pertussis toxin-sensitive G proteins leading to exocytosis...
  65. pmc Engineering the protein N-glycosylation pathway in insect cells for production of biantennary, complex N-glycans
    Jason Hollister
    Department of Molecular Biology, University of Wyoming, Laramie 82071, USA
    Biochemistry 41:15093-104. 2002
    ....
  66. ncbi Mutation of arginine 228 to lysine enhances the glucosyltransferase activity of bovine beta-1,4-galactosyltransferase I
    Boopathy Ramakrishnan
    Structural Glycobiology Section, Laboratory of Experimental and Computational Biology, Center for Cancer Research, National Cancer Institute Frederick, Frederick, Maryland 21702 1201, USA
    Biochemistry 44:3202-10. 2005
    ..This alternate conformation now causes a steric hindrance to the O4 hydroxyl group of the Gal moiety of UDP-Gal, probably causing the dissociation of UDP-Gal and the reduced k(cat) of the Gal-T reaction...
  67. pmc Binding of N-acetylglucosamine (GlcNAc) β1-6-branched oligosaccharide acceptors to β4-galactosyltransferase I reveals a new ligand binding mode
    Boopathy Ramakrishnan
    Structural Glycobiology Section, SAIC Frederick, Inc, Center for Cancer Research Nanobiology Program, Center for Cancer Research, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 287:28666-74. 2012
    ..Results from the present and previous studies suggest that β4Gal-T1 molecule has two different oligosaccharide binding regions for the binding of the extended oligosaccharide moiety of the acceptor substrate...
  68. ncbi Differential B lymphocyte galactosyltransferase activity in the MRL mouse model of rheumatoid arthritis
    J S Axford
    Department of Cellular and Molecular Sciences, St George s Hospital Medical School, London, UK
    Autoimmunity 17:157-63. 1994
    ..It is now important to further understand the mechanisms controlling glycosylation and relate disease associated changes with those occurring as part of normal cellular physiology...
  69. doi Lipopolysaccharide induced upregulation of beta-1,4-galactosyltransferase-I in Schwann cell
    Huiguang Yang
    Department of Orthopaedics, Affiliated Jiangyin Renmin Hospital of Nantong University, Key Laboratory for Neuroregeneration of JiangSu Province, Nantong University, Jiangsu, People s Republic of China
    Inflammation 32:279-86. 2009
    ..These results suggested that beta-1,4-GalT-I may play an important role in adhesion and migration of Schwann cells during inflammation...
  70. pmc Role of a cytoplasmic dual-function glycosyltransferase in O2 regulation of development in Dictyostelium
    Zhuo A Wang
    Department of Biochemistry and Molecular Biology and Oklahoma Center for Medical Glycobiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 284:28896-904. 2009
    ....
  71. doi Expression of beta-1,4-galactosyltransferase-I affects cellular adhesion in human peripheral blood CD4+ T cells
    Yu Han
    Department of Microbiology and Immunology, Medical School of Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, PR China
    Cell Immunol 262:11-7. 2010
    ..Collectively, the data suggest that beta-1,4-GalT-I plays a role in the cellular adhesion of CD4(+) T cells...
  72. ncbi [Cloning of Chinese Banna minipig inbred-line alpha1,3-galactosyltransferase gene and construction of its recombinant eukaryotic expression vector]
    Shengming Zhu
    Laboratory of Molecular Diagnosis of Cancer, West China Hospital, Sichuan University, Chengdu 610041, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 26:360-5. 2009
    ....
  73. doi Immune responses to alpha1,3 galactosyltransferase knockout pigs
    Gisella Puga Yung
    Service of Clinical Immunology and Allergology, Department of Internal Medicine, University Hospital and Medical Faculty, Geneva, Switzerland
    Curr Opin Organ Transplant 14:154-60. 2009
    ..In particular, we will address the nature of potentially remaining Gal epitopes, the role of non-Gal xenoantigens, and the cellular response directed against GalT-KO tissues...
  74. ncbi Effects of Zn(II) on galactosyltransferase activity
    E A Permyakov
    Department of Chemistry, Ohio State University, Columbus 43210
    J Protein Chem 12:633-8. 1993
    ..On the other hand, in N-acetyllactosamine synthesis, Zn(II) only slightly effects Km(app) for N-acetylglucosamine and has essentially no effect on Km(app) or Vm for UDP-galactose...
  75. pmc Systematic determination of the peptide acceptor preferences for the human UDP-Gal:glycoprotein-alpha-GalNAc beta 3 galactosyltransferase (T-synthase)
    Cynthia Perrine
    Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA
    Glycobiology 19:321-8. 2009
    ..This work suggests that there are indeed subtle specific and nonspecific protein-targeting sequence motifs for this transferase...
  76. pmc Coagulation dysregulation as a barrier to xenotransplantation in the primate
    Chih Che Lin
    Department of Immunology, Imperial College London, Hammersmith Hospital, London, UK
    Transpl Immunol 21:75-80. 2009
    ..This review summarizes recent studies of the coagulation problems associated with xenotransplantation, and discusses potential strategies to overcome them...
  77. ncbi Transcriptional regulation of murine beta1,4-galactosyltransferase in somatic cells. Analysis of a gene that serves both a housekeeping and a mammary gland-specific function
    B Rajput
    Cell Structure and Function Laboratory, Oncology Center Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287 8937, USA
    J Biol Chem 271:5131-42. 1996
    ..9-kb start site. These data experimentally support our conclusion that the 3.9-kb start site has been introduced into the mammalian beta4-GT gene to accommodate the recruited role of beta4-GT in lactose biosynthesis...
  78. doi Screening a limited structure-based library identifies UDP-GalNAc-specific mutants of alpha-1,3-galactosyltransferase
    Percy Tumbale
    Department of Biomedical Science, College of Biomedical Science, Florida Atlantic University, Glades Road, Boca Raton, FL 33431, USA
    Glycobiology 18:1036-43. 2008
    ..Mutational studies indicate that Leu283 is important for stability in this mutant...
  79. ncbi Mammary gland morphogenesis is inhibited in transgenic mice that overexpress cell surface beta1,4-galactosyltransferase
    H J Hathaway
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Development 122:2859-72. 1996
    ....
  80. ncbi Use of site-directed mutagenesis to identify the galactosyltransferase binding sites for UDP-galactose
    H Zu
    Department of Surgery, Medical College of Ohio, Toledo 43699
    Biochem Biophys Res Commun 206:362-9. 1995
    ....
  81. doi Metabolism of galactosyl-oligosaccharides in Stellaria media--discovery of stellariose synthase, a novel type of galactosyltransferase
    Mieke Vanhaecke
    Laboratory of Molecular Plant Physiology, Institute of Botany and Microbiology, K U Leuven, Kasteelpark Arenberg 31 2434, B 3001 Heverlee, Belgium
    Phytochemistry 71:1095-103. 2010
    ..Most likely, these compounds are also subject to partial trimming by endogenous alpha-galactosidases...
  82. ncbi Murine alpha 1,3-galactosyltransferase. A single gene locus specifies four isoforms of the enzyme by alternative splicing
    D H Joziasse
    Department of Medical Chemistry, Vrije Universiteit, Amsterdam, The Netherlands
    J Biol Chem 267:5534-41. 1992
    ..Similar results were obtained upon retinoic acid-induced differentiation of murine F9 teratocarcinoma cells. Lastly, a similar PCR analysis of bovine cDNA produced only a single DNA fragment, corresponding to bovine cDNA clone 31A...
  83. doi Expression analysis of an α-1, 3-galactosyltransferase, an enzyme that creates xenotransplantation-related α-Gal epitope, in pig preimplantation embryos
    Haiying Chi
    Laboratory of Animal Reproduction, Faculty of Agriculture Section of Gene Expression Regulation, Frontier Science Research Center, Kagoshima University, Kagoshima, Japan
    Anim Sci J 83:88-93. 2012
    ..Single embryo-based qRT-PCR also confirmed this pattern. These results indicate that creation of α-Gal epitope is proceeded by de novo synthesis of α-GalT mRNA in porcine preimplantation embryos with peaking at the blastocyst stage...
  84. doi DNA methylation and histone modifications modulate the β1,3 galactosyltransferase β3Gal-T5 native promoter in cancer cells
    Anna Caretti
    Department of Medicine, Surgery and Dentistry, San Paolo Hospital, Universita degli Studi di Milano, Milan, Italy
    Int J Biochem Cell Biol 44:84-90. 2012
    ..We conclude that complex epigenetic modulation underlies the regulation of β3Gal-T5 native promoter...
  85. pmc Specific enzyme complex of beta-1,4-galactosyltransferase-II and glucuronyltransferase-P facilitates biosynthesis of N-linked human natural killer-1 (HNK-1) carbohydrate
    Tetsuya Kouno
    Department of Biological Chemistry, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    J Biol Chem 286:31337-46. 2011
    ..These results indicate that the specific enzyme complex of β4GalT-II with GlcAT-P plays an important role in the biosynthesis of HNK-1 carbohydrate...
  86. pmc Probing elongating and branching β-D-galactosyltransferase activities in Leishmania parasites by making use of synthetic phosphoglycans
    Olga V Sizova
    College of Life Sciences, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, UK
    ACS Chem Biol 6:648-57. 2011
    ..Both L. major enzymes required a minimum of one phosphodiester group present in the substrate, but acceptors with two or three phosphodiester groups were found to be superior...
  87. ncbi Characterization of an alpha 1----3-galactosyltransferase homologue on human chromosome 12 that is organized as a processed pseudogene
    D H Joziasse
    Department of Medical Chemistry, Vrije Universiteit, Amsterdam, The Netherlands
    J Biol Chem 266:6991-8. 1991
    ..and Hakomori, S. (1990a) J. Biol. Chem. 265, 1146-1151), reveals a significant similarity (39%) suggesting that these two enzymes may have arisen from the same ancestral gene as a result of gene duplication and subsequent divergence...
  88. doi Differential effects of lobe A and lobe B of the Conserved Oligomeric Golgi complex on the stability of {beta}1,4-galactosyltransferase 1 and {alpha}2,6-sialyltransferase 1
    Romain Peanne
    Unité de Glycobiologie Structurale et Fonctionnelle UMR CNRS 8576, IFR147, Universite des Sciences et Technologies de Lille, Villeneuve d Ascq, France
    Glycobiology 21:864-76. 2011
    ..Lobe B would be crucial in preventing these two Golgi glycosyltransferases from inappropriate retrograde trafficking to the ER, whereas lobe A appears to be essential for maintaining the overall Golgi structure...
  89. doi Specificity of β1,4-galactosyltransferase inhibition by 2-naphthyl 2-butanamido-2-deoxy-1-thio-β-D-glucopyranoside
    Yin Gao
    Department of Medicine, Division of Rheumatology, Queen s University, Kingston, ON, K7L 3N6, Canada
    Glycoconj J 27:673-84. 2010
    ..In addition, 612 potently inhibits β4GalT in cell homogenates and thus allows assaying β3GalT activity in the presence of β4GalT...
  90. pmc Increased globotriaosylceramide levels in a transgenic mouse expressing human alpha1,4-galactosyltransferase and a mouse model for treating Fabry disease
    Chikara Shiozuka
    Department of Agricultural and Life Sciences, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
    J Biochem 149:161-70. 2011
    ..These data indicated that the TgG3S(+/-) M(+/-)/KO mouse was suitable for studying ASSC therapy for Fabry disease, and that the TgG3S mouse would be useful for studying the effect of high Gb3 levels in mouse organs...
  91. doi Tumor necrosis factor-α up-regulates the expression of β1,4-galactosyltransferase-I in human fibroblast-like synoviocytes
    Dawei Xu
    Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, 226001, People s Republic of China
    Inflammation 34:531-8. 2011
    ..These results suggest that TNF-α contributes to the up-regulation of β1,4-GalT-I mRNA in human FLSs...
  92. pmc Identification and characterization of in vitro galactosyltransferase activities involved in arabinogalactan-protein glycosylation in tobacco and Arabidopsis
    Yan Liang
    Department of Environmental and Plant Biology, Ohio University, Athens, Ohio 45701 2979, USA
    Plant Physiol 154:632-42. 2010
    ....
  93. doi Beta4-galactosyltransferase-5 is a lactosylceramide synthase essential for mouse extra-embryonic development
    Toshikazu Nishie
    Division of Transgenic Animal Science, Advanced Science Research Center, Kanazawa University, Kanazawa, Japan
    Glycobiology 20:1311-22. 2010
    ..Our results suggest that beta4GalT-5 is essential for extra-embryonic development during early mouse embryogenesis...
  94. doi Porcine beta1,4-galactosyltransferase-I sequence and expression
    E A Landers
    Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Reprod Domest Anim 44:228-34. 2009
    ..These results are important for studies of the function of this unusual and important glycosyltransferase during glycoprotein biosynthesis, lactation and fertilization...
  95. ncbi Suppressed UDP-galactose: ceramide galactosyltransferase and myelin protein mRNA in twitcher mouse brain
    M Taniike
    Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, 27599 7525, USA
    J Neurosci Res 51:536-40. 1998
    ..The increase of glial fibrillary acidic protein (GFAP) mRNA levels preceded morphological evidence of demyelination...
  96. ncbi Oligosaccharide preferences of beta1,4-galactosyltransferase-I: crystal structures of Met340His mutant of human beta1,4-galactosyltransferase-I with a pentasaccharide and trisaccharides of the N-glycan moiety
    Velavan Ramasamy
    Laboratory of Experimental and Computational Biology, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    J Mol Biol 353:53-67. 2005
    ..Present studies suggest that beta4Gal-T1 interacts preferentially with the 1,2-1,6-arm trisaccharide rather than with the 1,2-1,3-arm or 1,4-1,3-arm of a bi- or tri-antennary oligosaccharide chain of N-glycan...
  97. ncbi Defective glycosylation of decorin and biglycan, altered collagen structure, and abnormal phenotype of the skin fibroblasts of an Ehlers-Danlos syndrome patient carrying the novel Arg270Cys substitution in galactosyltransferase I (beta4GalT-7)
    Daniela G Seidler
    Department of Physiological Chemistry and Pathobiochemistry, Munster University Hospital, Munster, Germany
    J Mol Med (Berl) 84:583-94. 2006
    ....
  98. ncbi Isolation of the feline alpha1,3-galactosyltransferase gene, expression in transfected human cells and its phylogenetic analysis
    Bibhuti Bhusan Roy
    Department of Virology and Preventive Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    J Exp Zool B Mol Dev Evol 306:59-69. 2006
    ..Ratios of non-synonymous nucleotide changes among the primate pseudogenes as well as the primate genes are still higher than the ratios of non-primates, suggesting that the primate alpha1,3-GT genes tend to be divergent...

Research Grants80

  1. GALACTOSYLTRANSFERASES--STRUCTURE AND REGULATION
    Keith Brew; Fiscal Year: 2003
    ..The activity and structure will be investigated using a recombinant form of this protein. ..
  2. The Development of a Refrigerated Platelet Product
    HANS WANDALL; Fiscal Year: 2007
    ....
  3. Genetic Basis of Non-Familial IgA Nephropathy
    Tongzhong Ju; Fiscal Year: 2010
    ....
  4. Genetic Basis of Non-Familial IgA Nephropathy
    Tongzhong Ju; Fiscal Year: 2009
    ....
  5. Graft Rejection and Accommodation by anti-Gal mAbs
    Anita Chong; Fiscal Year: 2006
    ..We anticipate that these studies will lead to an improved understanding of the roles of antibodies in graft rejection and accommodation, and the development of new strategies to improve graft function in humans. ..
  6. Graft Rejection and Accommodation by anti-Gal mAbs
    Anita Chong; Fiscal Year: 2007
    ..We anticipate that these studies will lead to an improved understanding of the roles of antibodies in graft rejection and accommodation, and the development of new strategies to improve graft function in humans. ..
  7. GLYCOSYLTRANSFERASE FUNCTION DURING FERTILIZATION
    BARRY SHUR; Fiscal Year: 2006
    ..Finally, in the third Aim, we will continue our analysis of GalT-mediated signal transduction leading to the acrosome reaction. ..
  8. MOUSE GALTRANSFERASE--STRUCTURE/EXPRESSION
    JOEL SHAPER; Fiscal Year: 2004
    ..Consequently, it impacts only on male germ cell development but also on male infertility. ..
  9. ROLE OF CELL-SURFACE GLYCOSYLATION IN TUMOR METASTASIS
    Gerald Hart; Fiscal Year: 1992
    ..These studies are using the best available animal models of tumor metastasis to examine the mechanisms behind and the roles of altered glycosylation in generation of the metastatic phenotype...
  10. Role of Mucin-type O-glycans in Intestinal Inflammation
    Lijun Xia; Fiscal Year: 2010
    ..This work may lead to a novel therapy for patients with UC. ..
  11. Crystallization of the Galactosyltransferase from Mtb
    Robert Reynolds; Fiscal Year: 2002
    ..This effort, however, is innovative in the choice of target and the impact that structural biology can have on our funded program. ..
  12. Gene Targeting and xenotransplantation
    Jorge Piedrahita; Fiscal Year: 2006
    ....
  13. GLYCOSYLTRANSFERASE FUNCTION DURING FERTILIZATION
    BARRY SHUR; Fiscal Year: 2000
    ....