AZI2

Summary

Gene Symbol: AZI2
Description: 5-azacytidine induced 2
Alias: AZ2, NAP1, TILP, 5-azacytidine-induced protein 2, 5-azacytidine induced gene 2, NAK-associated protein 1, NF-kappa-B-activating kinase-associated protein 1
Species: human
Products:     AZI2

Top Publications

  1. Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, et al. Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol Cell Biol. 2003;23:7780-93 pubmed
    ..Here we identify NAP1 (for NAK-associated protein 1), a protein that interacts with NAK and its relative IKK epsilon (also known as IKKi)...
  2. Sasai M, Shingai M, Funami K, Yoneyama M, Fujita T, Matsumoto M, et al. NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction. J Immunol. 2006;177:8676-83 pubmed
    ..technology and human cell transfectants, we have revealed that knockdown of NAK-associated protein 1 (NAP1) leads to the down-regulation of IFN-beta promoter activation >24 h after poly(I:C) or virus (RSV and vesicular ..
  3. Ryzhakov G, Randow F. SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. EMBO J. 2007;26:3180-90 pubmed
    ..We have identified a new and essential component of this pathway, the adaptor protein SINTBAD (similar to NAP1 TBK1 adaptor). SINTBAD constitutively binds TBK1 and IKKi but not related kinases...
  4. Liu B. [Fulminant Clostridium difficile colitis: new challenges in critical care medicine]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:564-567 pubmed publisher
    ..In particular, the recently discovered mutant CD strain NAP1/BI/ribotype 027 has high pathogenicity in the global epidemic and its outbreak...
  5. De Curraize C, Rousseau C, Corvec S, El Helali N, Fihman V, Barbut F, et al. Variable spectrum of disease and risk factors of peripartum Clostridium difficile infection: report of 14 cases from French hospitals and literature review. Eur J Clin Microbiol Infect Dis. 2018;: pubmed publisher
    ..Diverse C. difficile PCR ribotypes were involved, but the BI/NAP1/027 strain was not detected in the French case series contrary to the literature cases...
  6. Namburi P, Ratnapriya R, Khateb S, Lazar C, Kinarty Y, Obolensky A, et al. Bi-allelic Truncating Mutations in CEP78, Encoding Centrosomal Protein 78, Cause Cone-Rod Degeneration with Sensorineural Hearing Loss. Am J Hum Genet. 2016;99:777-784 pubmed publisher
    ..CEP78 was reported previously to interact with c-nap1, encoded by CEP250 that we reported earlier to cause atypical Usher syndrome...
  7. von Eichel Streiber A, Paik W, Knight K, Gisch K, Nadjafi K, Decker C, et al. Induction of antitoxin responses in Clostridium-difficile-infected patients compared to healthy blood donors. Anaerobe. 2016;41:91-103 pubmed publisher
    ..Systemic responses to TcdB and mucosal responses to TcdA predominated. Among patients infected with the NAP1/027/BI strain, systemic IgG-anti-TcdB responses were particularly elevated...
  8. Wang S, Rustandi R, Lancaster C, Hong L, Thiriot D, Xie J, et al. Toxicity assessment of Clostridium difficile toxins in rodent models and protection of vaccination. Vaccine. 2016;34:1319-23 pubmed publisher
    ..The two major toxins, toxin A and toxin B are produced by most C. difficile bacteria, but some strains, such as BI/NAP1/027 isolates, produce a third toxin called binary toxin...
  9. Hernandez L, Racine F, Xiao L, Dinunzio E, Hairston N, Sheth P, et al. Broad coverage of genetically diverse strains of Clostridium difficile by actoxumab and bezlotoxumab predicted by in vitro neutralization and epitope modeling. Antimicrob Agents Chemother. 2015;59:1052-60 pubmed publisher
    ..neutralized toxins from culture supernatants of all clinical isolates tested, including multiple isolates of the BI/NAP1/027 and BK/NAP7/078 strains, at antibody concentrations well below plasma levels observed in humans...

More Information

Publications88

  1. Ramos Molina B, López Contreras A, Lambertos A, Dardonville C, Cremades A, Peñafiel R. Influence of ornithine decarboxylase antizymes and antizyme inhibitors on agmatine uptake by mammalian cells. Amino Acids. 2015;47:1025-34 pubmed publisher
    ..In cells transfected with any of the three ornithine decarboxylase antizymes (AZ1, AZ2 and AZ3), agmatine uptake was dramatically reduced...
  2. Ghose C, Eugenis I, Edwards A, Sun X, McBride S, Ho D. Immunogenicity and protective efficacy of Clostridium difficile spore proteins. Anaerobe. 2016;37:85-95 pubmed publisher
    ..difficile UK1, a clinically-relevant 027/B1/NAP1 strain. These spore proteins are also able to afford high levels of protection against challenge with C...
  3. Zhou W, Wang Y, Wu Z, Luo L, Liu P, Yan L, et al. Homologs of SCAR/WAVE complex components are required for epidermal cell morphogenesis in rice. J Exp Bot. 2016;67:4311-23 pubmed publisher
    ..and LPL3 encode the PIROGI/Specifically Rac1-associated protein 1 (PIR/SRA1)-like and NCK-associated protein 1 (NAP1)-like proteins, respectively, two components of the suppressor of cAMP receptor/Wiskott-Aldrich syndrome protein-..
  4. Kong L, Dendukuri N, Schiller I, Bourgault A, Brassard P, Poirier L, et al. Predictors of asymptomatic Clostridium difficile colonization on hospital admission. Am J Infect Control. 2015;43:248-53 pubmed publisher
    ..Of patients colonized on admission, 79.4% had non-NAP1, non-NAP2 strains...
  5. Dinh A, Bouchand F, Le Monnier A. [Current treatment and epidemiology of Clostridium difficile infections]. Rev Med Interne. 2015;36:596-602 pubmed publisher
    ..All these change are partially due to the emergence of the hypervirulent and hyperepidemic clone NAP1/B1/027...
  6. PARKER C, Gopalakrishnan S, Carbonetto P, Gonzales N, Leung E, Park Y, et al. Genome-wide association study of behavioral, physiological and gene expression traits in outbred CFW mice. Nat Genet. 2016;48:919-26 pubmed publisher
    ..We integrated the behavioral QTL and eQTL results to implicate specific genes, including Azi2 in sensitivity to methamphetamine and Zmynd11 in anxiety-like behavior...
  7. Cervenka I, Valnohova J, Bernatik O, Harnoš J, Radsetoulal M, Sedova K, et al. Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins. Proc Natl Acad Sci U S A. 2016;113:9304-9 pubmed publisher
    ..binding to CDK5 regulatory subunit-associated protein 2 (CDK5RAP2) and centrosomal Nek2-associated protein 1 (C-NAP1), two proteins of the centrosomal linker...
  8. Balachandran A, Wong R, Stoilov P, Pan S, Blencowe B, Cheung P, et al. Identification of small molecule modulators of HIV-1 Tat and Rev protein accumulation. Retrovirology. 2017;14:7 pubmed publisher
    ..Subsequent tests suggest that 791 may function by reducing levels of the Tat/Rev chaperone Nap1. The three compounds examined (791, 833, 892), despite their lack of structural similarity, all suppressed HIV-1 ..
  9. Shintomi K, Takahashi T, Hirano T. Reconstitution of mitotic chromatids with a minimum set of purified factors. Nat Cell Biol. 2015;17:1014-23 pubmed publisher
    ..mixing a simple substrate with only six purified factors: core histones, three histone chaperones (nucleoplasmin, Nap1 and FACT), topoisomerase II (topo II) and condensin I...
  10. Alcalá Hernández L, Mena Ribas A, Niubó Bosh J, Marín Arriaza M. [Laboratory diagnosis of Clostridium difficile infection]. Enferm Infecc Microbiol Clin. 2016;34:595-602 pubmed publisher
    ..The eruption of the hypervirulent strain BI/NAP1/027 has given rise to an increase in the morbidity and mortality of C.difficile infection (CDI)...
  11. Vlijm R, Lee M, Lipfert J, Lusser A, Dekker C, Dekker N. Nucleosome assembly dynamics involve spontaneous fluctuations in the handedness of tetrasomes. Cell Rep. 2015;10:216-25 pubmed publisher
    ..monitor the real-time loading of tetramers or complete histone octamers onto DNA by Nucleosome Assembly Protein-1 (NAP1)...
  12. Thabit A, Housman S, Burnham C, Nicolau D. Association of healthcare exposure with acquisition of different Clostridium difficile strain types in patients with recurrent infection or colonization after clinical resolution of initial infection. J Hosp Infect. 2016;92:167-72 pubmed publisher
    ..Patients did not differ with regard to age, sex, and whether the initial infection was with the BI/NAP1/027 strain. Ribotyping revealed that two out of five patients had recurrence attributed to a different strain type...
  13. Jing Z, Yin H, Wang P, Gao J, Yuan L. Centlein, a novel microtubule-associated protein stabilizing microtubules and involved in neurite formation. Biochem Biophys Res Commun. 2016;472:360-5 pubmed publisher
    We have previously reported that the centriolar protein centlein functions as a molecular link between C-Nap1 and Cep68 to maintain centrosome cohesion [1]...
  14. Chen J, Kao L, Jana S, Sivan Loukianova E, Mendonça S, Cabrera O, et al. Rootletin organizes the ciliary rootlet to achieve neuron sensory function in Drosophila. J Cell Biol. 2015;211:435-53 pubmed publisher
    ..report that Drosophila melanogaster Rootletin (Root), the sole orthologue of the mammalian paralogs Rootletin and C-Nap1, assembles into rootlets of diverse lengths among sensory neuron subtypes...
  15. Lee Y, Kim D, Ryu J, Zhang Y, Kim S, Kim Y, et al. Phosphorylation of CYFIP2, a component of the WAVE-regulatory complex, regulates dendritic spine density and neurite outgrowth in cultured hippocampal neurons potentially by affecting the complex assembly. Neuroreport. 2017;28:749-754 pubmed publisher
    ..the crystal structure of WRC and found that T1067 phosphorylation could weaken the interaction between CYFIP2 and Nap1 by inducing conformational changes of CYFIP2 α-helical bundles...
  16. Moraes L, Zanchin N, Cerutti J. ABI3, a component of the WAVE2 complex, is potentially regulated by PI3K/AKT pathway. Oncotarget. 2017;8:67769-67781 pubmed publisher
    ..37 ABI3 partners, including several components of the canonical WAVE regulatory complex (WRC) such as WAVE2/CYF1P1/NAP1, suggesting that ABI3 function might be regulated through WRC...
  17. Guh A, Mu Y, Baggs J, Winston L, Bamberg W, Lyons C, et al. Trends in incidence of long-term-care facility onset Clostridium difficile infections in 10 US geographic locations during 2011-2015. Am J Infect Control. 2018;46:840-842 pubmed publisher
    ..43%) across 10 US sites. A concomitant decline in inpatient fluoroquinolone use and the C difficile epidemic strain NAP1/027 among persons aged ?65 years may have contributed to the decrease in long-term-care facility-onset C difficile ..
  18. Knorz V, Spalluto C, Lessard M, Purvis T, Adigun F, Collin G, et al. Centriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731. Mol Biol Cell. 2010;21:3617-29 pubmed publisher
    ..to the proximal ends of centrioles and basal bodies, where it colocalizes with the centrosome cohesion protein C-Nap1. RNAi analysis reveals markedly diminished centrosomal levels of C-Nap1 and compromised cohesion of parental ..
  19. Malik S, Saito H, Takaoka M, Miki Y, Nakanishi A. BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein. Cell Cycle. 2016;15:2145-2156 pubmed
    ..The double depletion of BRCA2 and C-Nap1 caused a larger dispersion of centrosome distances than the silencing of C-Nap1...
  20. Saul V, Niedenthal R, Pich A, Weber F, Schmitz M. SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity. Biochim Biophys Acta. 2015;1853:136-43 pubmed publisher
    ..in the C-terminal coiled-coil domain which is exclusively responsible for the association with the adaptor proteins NAP1, Sintbad and TANK...
  21. Morgan D, Leekha S, Croft L, Burnham C, Johnson J, Pineles L, et al. The Importance of Colonization with Clostridium difficile on Infection and Transmission. Curr Infect Dis Rep. 2015;17:499 pubmed publisher
    ..for such an increase are unknown but may relate to antibiotic use and evolution of a new, pathogenic strain, NAP1/BI/027. The Centers for Disease Control and Prevention (CDC) identifies C...
  22. Yue H, Fang H, Wei S, Hayes J, Lee T. Single-Molecule Studies of the Linker Histone H1 Binding to DNA and the Nucleosome. Biochemistry. 2016;55:2069-77 pubmed publisher
    ..We found that histone chaperone Nap1 readily dissociates H1 from DNA and superstoichiometrically bound H1 from the nucleosome, supporting a hypothesis ..
  23. Wasels F, Kuehne S, Cartman S, Spigaglia P, Barbanti F, Minton N, et al. Fluoroquinolone resistance does not impose a cost on the fitness of Clostridium difficile in vitro. Antimicrob Agents Chemother. 2015;59:1794-6 pubmed publisher
    ..with the substitution Thr-82→Ile in GyrA, which characterizes the hypervirulent epidemic clone III/027/NAP1, were resistant to all fluoroquinolones tested...
  24. Gerding D, Lessa F. The epidemiology of Clostridium difficile infection inside and outside health care institutions. Infect Dis Clin North Am. 2015;29:37-50 pubmed publisher
    ..epidemiology since the late twentieth century and into the twenty-first century when the new epidemic strain BI/NAP1/027 emerged...
  25. Fan H, Liu Z, Chow S, Lu Y, Li H. Histone chaperone-mediated nucleosome assembly process. PLoS ONE. 2015;10:e0115007 pubmed publisher
    ..It was found that Asf1 is able to exert more influence than Nap1 and poly glutamate acid (PGA) on the nucleosome formation process, which highlights Asf1's specific role in ..
  26. Cejas D, Ríos Osorio N, Quiros R, Sadorin R, Berger M, Gutkind G, et al. Detection and molecular characterization of Clostridium difficile ST 1 in Buenos Aires, Argentina. Anaerobe. 2018;49:14-17 pubmed publisher
    ..Two/4 cdtA/B positives isolates corresponded to ST 1 resembling BI/NAP1/027/ST 1 strain, while the others corresponded to ST 226 and ST 377.
  27. Jia H, Du P, Yang H, Zhang Y, Wang J, Zhang W, et al. Nosocomial transmission of Clostridium difficile ribotype 027 in a Chinese hospital, 2012-2014, traced by whole genome sequencing. BMC Genomics. 2016;17:405 pubmed publisher
    The rapid spread of Clostridium difficile NAP1/BI/027 (C. difficile 027) has become one of the leading threats of healthcare-associated infections worldwide. However, C...
  28. Maity D, Jiang J, Ehlers M, Wu J, Schmuck C. A FRET-enabled molecular peptide beacon with a significant red shift for the ratiometric detection of nucleic acids. Chem Commun (Camb). 2016;52:6134-7 pubmed publisher
    A cationic molecular peptide beacon NAP1 functionalized with a fluorescence resonance energy transfer-pair at its ends allows the ratiometric detection of ds-DNA with a preference for AT rich sequences...
  29. Costa C, López Ureña D, de Oliveira Assis T, Ribeiro R, Silva R, Rupnik M, et al. A MLST Clade 2 Clostridium difficile strain with a variant TcdB induces severe inflammatory and oxidative response associated with mucosal disruption. Anaerobe. 2016;40:76-84 pubmed publisher
    ..Unlike epidemic NAP1/027 strains, which are also classified to MLST Clade 2, strain ICC-45 is susceptible to fluoroquinolones and does ..
  30. Yao Z, Wu D, Liu J, Wu W, Zhao H, Tang J. Recycling of typical difficult-to-treat e-waste: Synthesize zeolites from waste cathode-ray-tube funnel glass. J Hazard Mater. 2017;324:673-680 pubmed publisher
    ..0. At the temperature of 110°C (pressure 1.43bar), NaA formed with a mixture of NaP1 and Faujasite...
  31. Hermassi M, Dosta J, Valderrama C, Licon E, Moreno N, Querol X, et al. Simultaneous ammonium and phosphate recovery and stabilization from urban sewage sludge anaerobic digestates using reactive sorbents. Sci Total Environ. 2018;630:781-789 pubmed publisher
    ..Na zeolites (NaP1-NA, NaP1-IQE) demonstrated efficiency on ammonium stabilization between 60±2 (for 15gZ/L) to 90±3% (for 50gZ/L)...
  32. Flanagan A, Stavenschi E, Basavaraju S, Gaboriau D, Hoey D, Morrison C. Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification. Mol Biol Cell. 2017;28:736-745 pubmed publisher
    ..are held together by a proteinaceous linker made up of rootletin filaments anchored to the centrioles by C-NAP1. This linker is removed in a NEK2A kinase-dependent manner as mitosis begins...
  33. Bouza E, Alcala L, Marin M, Valerio M, Reigadas E, Munoz P, et al. An outbreak of Clostridium difficile PCR ribotype 027 in Spain: risk factors for recurrence and a novel treatment strategy. Eur J Clin Microbiol Infect Dis. 2017;36:1777-1786 pubmed publisher
    An outbreak of Clostridium difficile infection (CDI) caused by ribotype 027 (B1/NAP1) began in our hospital in November 2014, and produced 141 episodes in the following months...
  34. Quesada Gómez C, López Ureña D, Chumbler N, Kroh H, Castro Peña C, Rodríguez C, et al. Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities. Infect Immun. 2016;84:856-65 pubmed publisher
    ..This strain (NAP1V) belongs to the NAP1 genotype but to a ribotype different from the epidemic NAP1/RT027 strain...
  35. Onishi M, Pringle J, Cross F. Evidence That an Unconventional Actin Can Provide Essential F-Actin Function and That a Surveillance System Monitors F-Actin Integrity in Chlamydomonas. Genetics. 2016;202:977-96 pubmed publisher
    ..A highly divergent actin gene, NAP1, is upregulated in ida5-1 cells, but it has been unclear whether NAP1 can form filaments or provide actin function...
  36. Tian J, Glenn G, FLYER D, Zhou B, Liu Y, Sullivan E, et al. Clostridium difficile chimeric toxin receptor binding domain vaccine induced protection against different strains in active and passive challenge models. Vaccine. 2017;35:4079-4087 pubmed publisher
    ..Over the past decade, however, highly virulent epidemic strains of C. difficile (B1/NAP1/027) have emerged and are linked to an increase in morbidity and mortality...
  37. Murai N, Murakami Y, Tajima A, Matsufuji S. Novel ubiquitin-independent nucleolar c-Myc degradation pathway mediated by antizyme 2. Sci Rep. 2018;8:3005 pubmed publisher
    ..Here we show that a polyamine regulatory protein, antizyme 2 (AZ2), interacts with c-Myc in the nucleus and nucleolus, to accelerate proteasome-mediated c-Myc degradation without ..
  38. Yagi H, Fujise A, Itabashi N, Ohshiro T. Purification and characterization of a novel alginate lyase from the marine bacterium Cobetia sp. NAP1 isolated from brown algae. Biosci Biotechnol Biochem. 2016;80:2338-2346 pubmed
    ..AlgC-PL7 was isolated from the halophilic Gram-negative bacterium Cobetia sp. NAP1 collected from the brown algae Padina arborescens Holmes...
  39. Gomez E, Montgomery S, Alby K, Robinson D, Roundtree S, Blecker Shelly D, et al. Poor yield of Clostridium difficile testing algorithms using glutamate dehydrogenase antigen and C. difficile toxin enzyme immunoassays in a pediatric population with declining prevalence of clostridium difficile strain BI/NAP1/027. Diagn Microbiol Infect Dis. 2018;91:229-232 pubmed publisher
    ..9.6% of samples were ribotype 027. Algorithms may detect CDI with lower sensitivity compared to molecular methods in children. This may be related to low prevalence of NAP-1/ribotype 027. ..
  40. Fountain E, Moses M, Park L, Woods C, Arepally G. Thrombocytopenia in hospitalized patients with severe clostridium difficile infection. J Thromb Thrombolysis. 2017;43:38-42 pubmed publisher
    ..community), NAP1/027 strain, and disease severity has not been examined...
  41. Wang Y, Qin X, Zhu X, Chen W, Zhang J, Chen W. Oral cancer-derived exosomal NAP1 enhances cytotoxicity of natural killer cells via the IRF-3 pathway. Oral Oncol. 2018;76:34-41 pubmed publisher
    ..In addition, NF-?B-activating kinase-associated protein 1 (NAP1), an upstream activator of IRF-3, was enriched in OCEXs, and treatment with OCEXs increased the expression of NAP1 ..
  42. Khanafer N, Barbut F, Eckert C, Perraud M, Demont C, Luxemburger C, et al. Factors predictive of severe Clostridium difficile infection depend on the definition used. Anaerobe. 2016;37:43-8 pubmed publisher
    ..Over the past decade, the emergence of the BI/NAP1/027 strain has been linked to higher prevalence and severity of CDI...
  43. Roth B, Varney K, Rustandi R, Weber D. (1)H(N), (13)C, and (15)N resonance assignments of the CDTb-interacting domain (CDTaBID) from the Clostridium difficile binary toxin catalytic component (CDTa, residues 1-221). Biomol NMR Assign. 2016;10:335-9 pubmed publisher
    ..difficile strain, NAP1. Along with the large Clostridial toxins expressed by non-epidemic strains, C...
  44. Phulpoto A, Qazi M, Haq I, Phul A, Ahmed S, Kanhar N. Ecotoxicological assessment of oil-based paint using three-dimensional multi-species bio-testing model: pre- and post-bioremediation analysis. Environ Sci Pollut Res Int. 2018;25:16567-16577 pubmed publisher
    The present study validates the oil-based paint bioremediation potential of Bacillus subtilis NAP1 for ecotoxicological assessment using a three-dimensional multi-species bio-testing model...
  45. McMillen T, Kamboj M, Babady N. Comparison of Multilocus Sequence Typing and the Xpert C. difficile/Epi Assay for Identification of Clostridium difficile 027/NAP1/BI. J Clin Microbiol. 2016;54:775-8 pubmed publisher
    Clostridium difficile 027/NAP1/BI is the most common C. difficile strain in the United States. The Xpert C. difficile/Epi assay allows rapid, presumptive identification of C. difficile NAP1. We compared Xpert C...
  46. Yeruva L, Bowlin A, Spencer N, Maurelli A, Rank R. Chlamydial variants differ in ability to ascend the genital tract in the guinea pig model of chlamydial genital infection. Infect Immun. 2015;83:3176-83 pubmed publisher
    ..variant, could be isolated from the oviducts more often and in greater numbers than the attenuated variant, AZ2. SP6 also elicited higher levels of interleukin 8 (IL-8) in the lower genital tract and increased leukocyte ..
  47. Vlijm R, Li X, Panic M, Rüthnick D, Hata S, Herrmannsdörfer F, et al. STED nanoscopy of the centrosome linker reveals a CEP68-organized, periodic rootletin network anchored to a C-Nap1 ring at centrioles. Proc Natl Acad Sci U S A. 2018;115:E2246-E2253 pubmed publisher
    The centrosome linker proteins C-Nap1, rootletin, and CEP68 connect the two centrosomes of a cell during interphase into one microtubule-organizing center...
  48. Chen X, D Arcy S, Radebaugh C, Krzizike D, Giebler H, Huang L, et al. Histone Chaperone Nap1 Is a Major Regulator of Histone H2A-H2B Dynamics at the Inducible GAL Locus. Mol Cell Biol. 2016;36:1287-96 pubmed publisher
    Histone chaperones, like nucleosome assembly protein 1 (Nap1), play a critical role in the maintenance of chromatin architecture...
  49. Lanis J, Heinlen L, James J, Ballard J. Clostridium difficile 027/BI/NAP1 encodes a hypertoxic and antigenically variable form of TcdB. PLoS Pathog. 2013;9:e1003523 pubmed publisher
    ..Herein, we show that TcdB from the epidemic BI/NAP1/027 strain of C...
  50. Devera T, Lang G, Lanis J, Rampuria P, Gilmore C, James J, et al. Memory B Cells Encode Neutralizing Antibody Specific for Toxin B from the Clostridium difficile Strains VPI 10463 and NAP1/BI/027 but with Superior Neutralization of VPI 10463 Toxin B. Infect Immun. 2016;84:194-204 pubmed publisher
    ..CTD was produced from the historical VPI 10463 strain (CTD1) and from the hypervirulent strain NAP1/BI/027 (CTD2)...
  51. Hellström Lindahl E, Aberg O, Ericsson C, O Mahony G, Johnström P, Skrtic S, et al. Toward molecular imaging of the free fatty acid receptor 1. Acta Diabetol. 2017;54:663-668 pubmed publisher
    ..of FFAR1 in human, we evaluated tritiated small molecule FFAR1 binding probes ([3H]AZ1, [3H]AZ2 and [3H]TAK-875) for their off-target binding, receptor density and affinity in human pancreatic tissue (..
  52. L M, Soliman M. The binding landscape of plasmepsin V and the implications for flap dynamics. Mol Biosyst. 2016;12:1457-67 pubmed publisher
    ..structure of PlmV is unique compared to other plasmepsins; it is stabilised internally by seven disulfide bonds, a NAP1 insert/fold is associated with the movement of the flap covering the active site and a highly conserved helix-turn-..
  53. Dudzicz S, Adamczak M, Wiecek A. Clostridium Difficile Infection in the Nephrology Ward. Kidney Blood Press Res. 2017;42:844-852 pubmed publisher
    ..This may be a consequence of excessive antibiotic use and spread of the hypervirulent epidemic BI/NAP1/027 strain of Clostridium difficile...
  54. Unterholzner L, Sumner R, Baran M, Ren H, Mansur D, Bourke N, et al. Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7. PLoS Pathog. 2011;7:e1002247 pubmed publisher
    ..Consistent with this notion, C6 immunoprecipitated with the TBK1 complex scaffold proteins TANK, SINTBAD and NAP1. C6 is expressed early during infection and is present in both nucleus and cytoplasm...
  55. Pérez Topete S, Miranda Aquino T, Ayala Gaytán J. [Case series of Clostridium difficile NAP1/027/BI with novels treatments]. Rev Med Inst Mex Seguro Soc. 2017;55:654-659 pubmed
    ..We present three cases of Clostridium difficile NAP1/027/BI associated infection, they were presented with different clinical manifestations...
  56. Chen H, MacDonald A, Coffino P. Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase. J Biol Chem. 2002;277:45957-61 pubmed
    ..lysate, antizyme 1 (AZ1) accelerates proteasomal ornithine decarboxylase (ODC) degradation, but antizyme 2 (AZ2) does not...
  57. Liu K, Yu J, Zhao J, Zhou Y, Xiong N, Xu J, et al. AZI23'UTR Is a New SLC6A3 Downregulator Associated with an Epistatic Protection Against Substance Use Disorders. Mol Neurobiol. 2018;55:5611-5622 pubmed publisher
    ..variant of the gene, intron 1 DNP1B sequence, as bait to screen and clone a new transcriptional activity, AZI23'UTR, for SLC6A3...
  58. Tamez Torres K, Torres González P, Leal Vega F, García Alderete A, López García N, Mendoza Aguilar R, et al. Impact of Clostridium difficile infection caused by the NAP1/RT027 strain on severity and recurrence during an outbreak and transition to endemicity in a Mexican tertiary care center. Int J Infect Dis. 2017;65:44-49 pubmed publisher
    ..The presence of virulence factors among non-RT027 C. difficile strains underscores the importance of performing molecular epidemiology surveillance. ..
  59. Sasai M, Oshiumi H, Matsumoto M, Inoue N, Fujita F, Nakanishi M, et al. Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation. J Immunol. 2005;174:27-30 pubmed
    ..The results are: 1) the TANK family protein NAK-associated protein 1 (NAP1), but not TANK, coprecipitates withTICAM-1; 2) NAP1 overexpression markedly enhances TBK1-mediated IFN-beta ..
  60. Mazo G, Soplop N, Wang W, Uryu K, Tsou M. Spatial Control of Primary Ciliogenesis by Subdistal Appendages Alters Sensation-Associated Properties of Cilia. Dev Cell. 2016;39:424-437 pubmed publisher
    ..we found that a group of sDAP components localize to the centriole proximal end through the cohesion factor C-Nap1 and that sDAP function redundantly with C-Nap1 for submerged cilia maintenance...
  61. Antosz W, Pfab A, Ehrnsberger H, Holzinger P, Köllen K, Mortensen S, et al. The Composition of the Arabidopsis RNA Polymerase II Transcript Elongation Complex Reveals the Interplay between Elongation and mRNA Processing Factors. Plant Cell. 2017;29:854-870 pubmed publisher
    ..Additionally, NAP1 histone chaperones, ATP-dependent chromatin remodeling factors, and some histone-modifying enzymes including ..
  62. Hamp J, Löwer A, Dottermusch Heidel C, Beck L, Moussian B, Flötenmeyer M, et al. Drosophila Kette coordinates myoblast junction dissolution and the ratio of Scar-to-WASp during myoblast fusion. J Cell Sci. 2016;129:3426-36 pubmed publisher
    ..Severe defects in myoblast fusion are caused by the loss of Kette (a homolog of Nap1 and Hem-2, also known as NCKAP1 and NCKAP1L, respectively), a member of the regulatory complex formed by Scar or ..
  63. Prasad N, Labaze G, Kopacz J, Chwa S, Platis D, Pan C, et al. Asymptomatic rectal colonization with carbapenem-resistant Enterobacteriaceae and Clostridium difficile among residents of a long-term care facility in New York City. Am J Infect Control. 2016;44:525-32 pubmed publisher
    ..to determine prevalence of asymptomatic rectal colonization with Clostridium difficile (and proportion of 027/NAP1/BI ribotype) or carbapenem-resistant Enterobacteriaceae (CRE) in an LTCF population...
  64. Reddy D, Bhattacharya S, Jani V, Sonavane U, Joshi R, Gupta S. Biochemical and Biophysical Characterisation of Higher Oligomeric Structure of Rat Nucleosome Assembly Protein 1. Protein J. 2018;37:58-69 pubmed publisher
    Nucleosome assembly protein 1 (NAP1) is a histone chaperone that exchanges histone H2A-H2B dimer from chromatin templates. Studies with yeast NAP1 (yNAP1) have revealed its existence as multiple oligomeric species in solution...
  65. Plessis P, Ojumu T, Petrik L. Waste Minimization Protocols for the Process of Synthesizing Zeolites from South African Coal Fly Ash. Materials (Basel). 2013;6:1688-1703 pubmed publisher
    ..This result could be used to establish a basis for legal and environmental aspects involved in the commission of a full-scale plant synthesizing zeolites NaP1 and analcime.
  66. Funami K, Sasai M, Ohba Y, Oshiumi H, Seya T, Matsumoto M. Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA. J Immunol. 2007;179:6867-72 pubmed
    ..In addition, NF-kappaB-activating kinase-associated protein 1 (NAP1), a downstream molecule linking TICAM-1 and the IRF-3-activating kinase TBK1 (TANK-binding kinase 1), was also ..
  67. Tanaka T, Hozumi Y, Iino M, Goto K. NAP1L1 regulates NF-?B signaling pathway acting on anti-apoptotic Mcl-1 gene expression. Biochim Biophys Acta Mol Cell Res. 2017;1864:1759-1768 pubmed publisher
    ..Of those, the human NAP1-like protein (NAP1L) family functions in the transport, assembly/disassembly of nucleosome core particles...
  68. Zhao W, Wang L, Zhang M, Wang P, Yuan C, Qi J, et al. Tripartite motif-containing protein 38 negatively regulates TLR3/4- and RIG-I-mediated IFN-? production and antiviral response by targeting NAP1. J Immunol. 2012;188:5311-8 pubmed publisher
    ..colocalization experiments demonstrated that TRIM38 interacted with NF-?B-activating kinase-associated protein 1 (NAP1), which is required for TLR-induced IFN regulatory factor 3 activation and IFN-? production...
  69. Tkhawkho L, Nitzan O, Pastukh N, Brodsky D, Jackson K, Peretz A. Antimicrobial susceptibility of Clostridium difficile isolates in Israel. J Glob Antimicrob Resist. 2017;10:161-164 pubmed publisher
    ..difficile infection. Specimens were screened for BI/NAP1/027 ribotype, cultured, and sensitivity tests were performed for vancomycin, metronidazole, moxifloxacin, and ..
  70. Le Breton M, Meyniel Schicklin L, Deloire A, Coutard B, Canard B, de Lamballerie X, et al. Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen. BMC Microbiol. 2011;11:234 pubmed publisher
    ..Our virus-host interaction map provides a basis to unravel fundamental processes about flavivirus subversion of the host replication machinery and/or immune defence strategy. ..
  71. Bauer K, Johnston J, Wenzler E, Goff D, Cook C, Balada Llasat J, et al. Impact of the NAP-1 strain on disease severity, mortality, and recurrence of healthcare-associated Clostridium difficile infection. Anaerobe. 2017;48:1-6 pubmed publisher
    Studies are conflicting regarding the association of the North American pulsed-field gel electrophoresis type 1 (NAP1) strain in Clostridium difficile infection (CDI) and outcomes...
  72. Lee J, Lake R, Kirk J, Bohr V, Fan H, Hohng S. NAP1L1 accelerates activation and decreases pausing to enhance nucleosome remodeling by CSB. Nucleic Acids Res. 2017;45:4696-4707 pubmed publisher
    ..CSB alone remodels nucleosomes ?10-fold slower than the ACF remodeling complex. Strikingly, NAP1-like histone chaperones interact with CSB and greatly enhance CSB-mediated chromatin remodeling...
  73. Fang R, Jiang Q, Zhou X, Wang C, Guan Y, Tao J, et al. MAVS activates TBK1 and IKK? through TRAFs in NEMO dependent and independent manner. PLoS Pathog. 2017;13:e1006720 pubmed publisher
    ..TBK1 and IKK?/?, is unclear, although previous work suggests the involvement of NEMO or TBK1-binding proteins TANK, NAP1, and SINTBAD...
  74. Dronamraju R, Ramachandran S, Jha D, Adams A, DiFiore J, Parra M, et al. Redundant Functions for Nap1 and Chz1 in H2A.Z Deposition. Sci Rep. 2017;7:10791 pubmed publisher
    ..Z is deposited by the SWR-C complex, which relies on several histone chaperones including Nap1 and Chz1 to deliver H2A.Z-H2B dimers to SWR-C. However, the mechanisms by which Nap1 and Chz1 cooperate to bind H2A...
  75. Seo S, Solivan Timpe F, Roos B, Robin A, Stone E, Kwon Y, et al. Identification of proteins that interact with TANK binding kinase 1 and testing for mutations associated with glaucoma. Curr Eye Res. 2013;38:310-5 pubmed publisher
    ..TAP studies show that three proteins expressed in HEK-293T cells (NAP1, TANK and TBKBP1) interact with TBK1...
  76. Fan Y, Li Y, Wu D, Li C, Kong H. Application of zeolite/hydrous zirconia composite as a novel sediment capping material to immobilize phosphorus. Water Res. 2017;123:1-11 pubmed publisher
    ..In the ZHZ, NaP1 zeolite was covered with hydrous zirconia, which existed as an amorphous phase...
  77. Lee J, Lee T. Single-Molecule Investigations on Histone H2A-H2B Dynamics in the Nucleosome. Biochemistry. 2017;56:977-985 pubmed publisher
    ..the early kinetics of H2A-H2B dimer dissociation triggered by high salt concentration and by histone chaperone Nap1. The results reveal that dimer displacement requires DNA unwrapping in the vast majority of the nucleosomes in the ..
  78. Miyagawa J, Muguruma M, Aoto H, Suetake I, Nakamura M, Tajima S. Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus. Gene. 1999;240:289-95 pubmed
    We have isolated a novel cDNA clone, named AZ2, from a cDNA library of mRNA prepared from C3H10T1/2 cells that had been transiently exposed to 5-azacytidine, a potent inhibitor of DNA methyltransferase...
  79. Giancola S, Williams R, Gentry C. Prevalence of the Clostridium difficile BI/NAP1/027 strain across the United States Veterans Health Administration. Clin Microbiol Infect. 2018;24:877-881 pubmed publisher
    ..of Clostridium difficile infection (CDI) are thought to result partly from the emergence of the hypervirulent BI/NAP1/027 strain. Limited recent data are available on the prevalence of BI/NAP1/027 in the United States (US)...